Authors:R. K. Gupta, M. Lohani, R. Vishwakarma Pages: 63 - 66 Abstract: Traditionally, Bryophyllum pinnatum is used in the management of arthritis and inflammatory diseases. However, B. pinnatum has not been analysed previously for anti-inflammatory activity. Hence, this study is designed to determine the anti-inflammatory effects of various fractions of B. pinnatum leaf extract using rat model of formalin-induced paw edema. Treatment with various fractions showed marked decrease in formalin-induced paw volume and edema in rats. The results of BPAAF treatment were comparable to standard drug, diclofenac. These results indicate that B. pinnatum could be developed as ant-inflammatory drug after further studies. PubDate: 2019-11-05 DOI: 10.15415/jptrm.2019.72008 Issue No:Vol. 7, No. 2 (2019)
Authors:R. A. Ahirrao, B. S. Patange, S. V. More Pages: 67 - 71 Abstract: Natural occurring phenolic compounds play an important role in cancer prevention and shows antimitotic activity. Number of active constituents like phenolic acid, curcuminoids, coumarine, ligans, quinones, etc. is showing antimitotic activity of Momordica dioica. The present work is on phytochemical investigation and examines antimitotic activity of aqueous extract of fruits Momordica dioica at concentration of 15 mg/ml on Allium cepa root meristamatic cells. The fruits are air dried and extracted with solvents like water by maceration method. The evaluation of antimitotic activity is done by using Allium cepa root meristamatic cells parameters where and methotrexate was used as a standard drugs. In Allium assay, aqueous extract of fruits of Momordica diocia (15 mg/ml) and methotrexate act against cells of allium roots and lesser the growth of root and mitotic index when compared with distilled water as control group. The result indicated that cytotoxic property is due to presence of phenolic, alkaloids and flavonoids compounds in 15 mg/ml concentration of aqueous extract of Momordica diocia fruits extract. On the basis of result, we concluded that, 15 mg/ml concentration of Momordica dioica fruits shows good antimitotic activity on the Allium cepa root tip assay. PubDate: 2019-11-05 DOI: 10.15415/jptrm.2019.72009 Issue No:Vol. 7, No. 2 (2019)
Authors:Nidhi Garg, Suman Baishnab, Rosy Das, Kiranjeet Kaur, Saurabh Gupta, Sandeep Arora Pages: 73 - 86 Abstract: Breast cancer is the most common cancer across the globe occurring commonly in women population, and it is one of the main causes of mortality in women. In 2018, 1,62,468 new cases and 87,090 death cases of breast cancer were registered in India. In these recent years, lots of studies were conducted in breast cancer related to treatment and management, but in spite of getting so much advancement in the treatment of breast cancer still, the mortality rate of women is increasing day by day. Numerous factors are acting as barriers or challenges in breast cancer preventive therapy. It includes lack of knowledge regarding the treatment of cancer and patient getting insecure about treatment, fear of having side effects, cost of treatment and the efficacy of the drugs being prescribed. The study intended to determine the perceived insights and barriers to treatment of breast cancer. PubDate: 2019-11-05 DOI: 10.15415/jptrm.2019.72010 Issue No:Vol. 7, No. 2 (2019)
Authors:Simran, Amarjot Kaur Grewal, Sandeep Arora, Thakur Gurjeet Singh Pages: 87 - 95 Abstract: Diabetes is the most common and systemic disorder associated with hyperglycemia which is the significant factor in the development of micro- and macrovascular changes. Many mechanistic approaches i.e. activation of Protein kinase C, glycation end products production, hexosamine pathway and polyol pathway induce cellular damage and lead to the development of diabetic complications like nephropathy, neuropathy, retinopathy, and myopathy. One of the adverse effects of long-lasting hyperglycemia is activation of PKC (intracellular signaling enzyme) and has become a field of great research interest. Hence, in this review special emphasis is placed on microvascular complications which are due to activation of PKC. Clinical trials have also been conducted using selective PKC inhibitors and have shown positive results against hyperglycemia. PubDate: 2019-11-05 DOI: 10.15415/jptrm.2019.72011 Issue No:Vol. 7, No. 2 (2019)
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