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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
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Natural Product Communications
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  This is an Open Access Journal Open Access journal
ISSN (Print) 1934-578X - ISSN (Online) 1555-9475
Published by Sage Publications Homepage  [1176 journals]
  • Investigation of the Anti-Diabetic Potential of Coccinia barteri (Hook.F.)
           Leaf Using in Vitro and in Silico Molecular Docking Approaches

    • Authors: Sabastine Obinna Onugwu, Patrick Ebele Obi, Ginikachukwu Okoh, Adaeze Linda Onugwu, Rosemary Chidera Madubugwu, Tracy Osita, Ogochukwu Henrietta Nnamani, Uchenna Estella Odoh, Christopher Obodike Ezugwu
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      Objectives/BackgroundSeveral plants with various chemical constituents have been widely explored for managing diabetes mellitus. One of the most common strategies is the inhibitors of the α-amylase and α-glucosidase, key regulatory enzymes in diabetes. This study aims to investigate the anti-diabetic activity of methanolic extract of Coccinia barteri leaves using in vitro α-amylase enzyme inhibition assay and in silico molecular docking study.MethodsThe dried pulverized leaf of Coccinia barteri was extracted by maceration using methanol. Qualitative and quantitative phytochemical analyses of the powdered leaf extract were carried out using standard procedures. The extract was fractionated using n-hexane, ethyl acetate, n-butanol and aqueous methanol. In vitro anti-diabetic study of the different fractions and sub-fractions was investigated by α-Amylase Inhibition Assay. Sub-fractions of the ethyl acetate fraction of C.barteri leaf with the highest in vitro anti-diabetic activity were subjected to GC-MS analysis. The compounds detected by GC-MS were selected as ligands for α-amylase and α-glucosidase in the molecular docking study.ResultsThe phytochemical analysis revealed the presence of saponins, alkaloids, tannins, glycosides, steroids, flavonoids, and cyanide. Compared to the control drug, the ethyl acetate fraction of Coccinia barteri leaf gave a 2-fold lower IC50. GCMS chromatogram of the most active sub-fraction revealed the presence of 18 major compounds. Piperine showed good binding affinity (−6.9 kcal/mol) to α-amylase and displayed hydrogen bonding with ARG 344 and HIS 210, along with pi alkyl bonds with TRP 83, HIS 80, LEU 166, and LEU 232. For α-glucosidase, piperine and 2,4-di-tertbutylphenol surpassed the standard with binding energies of −7.1 kcal/mol and - 6.9 kcal/mol, respectively. Drug likeness and toxicity assessments confirmed adherence to Lipinski's rule, with both compounds showing non-mutagenic and non-tumorigenic properties.ConclusionThe ethyl acetate fraction of the Coccinia barteri leaf exhibits potential anti-diabetic activity, which may be attributed to the inhibition of α-amylase and α-glucosidase, by its constituents, piperine and 2,4-di-tertbutylphenol.
      Citation: Natural Product Communications
      PubDate: 2024-08-07T11:21:05Z
      DOI: 10.1177/1934578X241271633
      Issue No: Vol. 19, No. 8 (2024)
       
  • Comparison of the Efficacy and Safety of 12 Chinese Patent Medicines for
           Treating Primary Osteoporosis Patients: A Systematic Review and Network
           Meta-Analysis

    • Authors: Qinglin Peng, Jie Han, Ruiqi Wu, Yukun Wu, Feng Chen, Yu Lai
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      Objective: To elucidate the effectiveness and safety of different traditional Chinese medicines (TCMs) for treating primary osteoporosis (POP) using network meta-analysis. Materials and Methods: We conducted a systematic review and network meta-analysis to assess the efficacy and safety of Chinese patent medicine (CPM) combined with conventional Western medicine for POP treatment. From March 5, 2004, to March 5, 2024, electronic databases such as the Cochrane Library, VIP, PubMed, Embase, CBM, Wanfang, CNKI, and Web of Science were comprehensively searched. Only randomized controlled trials (RCTs) were included in this systematic review. After screening and data extraction, the Cochrane risk of bias evaluation tool was utilized to assess the methodological quality of the included studies. Stata 15.1 was utilized to synthesize the data. Results: In total, 44 studies involving 4859 patients were included. There were 2577 patients in the treatment group and 2282 in the control group, with 12 types of CPMs. Qing'e Pill, in combination with conventional treatment, significantly improved the total effective rate [relative risk (RR) = 2.57, 95% confidence interval (CI) (1.32, 5.00)]. In combination with conventional treatment, Liuwei Dihuang Pill significantly increased the bone mass density (BMD) of the lumbar spine [WMD = 0.17, 95% CI (0.05, 0.28)] and femoral neck [WMD = 0.23, 95% CI (0.11, 0.35)]. Furthermore, Hugu capsules effectively decreased the VAS score [WMD = −2.48, 95% CI (−3.85, −1.11)]. The presence of the genus Gusongbao markedly decreased the serum ALP concentration [WMD = −15.67, 95% CI (−32.73, 1.39)]. In all studies, no serious adverse reactions were noted, with most studies suggesting only mild gastrointestinal reactions. Conclusions: CPM and conventional treatment combo enhances POP therapy; each CPM offers unique benefits. More high-quality RCTs needed for conclusions. Meds tailored to patient traits in clinics.
      Citation: Natural Product Communications
      PubDate: 2024-08-07T03:13:46Z
      DOI: 10.1177/1934578X241271671
      Issue No: Vol. 19, No. 8 (2024)
       
  • Inhibitory activities of Aruncus dioicus alkaloidal glycosides against
           protein tyrosine phosphatase 1B and α-glucosidase: A methodical
           theory-experiment investigation

    • Authors: Phi-Hung Nguyen, Thanh Q. Bui, Thi-Tuyen Tran, Thi-Thuc Bui, Thi-Thuy Do, Dao-Cuong To, Manh Hung Tran, Phan Tu Quy, Nguyen Quang Co, Nguyen Vinh Phu, Nguyen Thi Ai Nhung
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      Objective: Aruncus dioicus has been known by the scientific literature and folk experiences for its diverse biological activities, including anti-hyperglycemic effects. Methodology: The aerial parts of the plant collected from Quan Lan Island (Vietnam) were subjected to a methodical theory-experiment investigation for its chemical composition and biological potentials. Results: Firstly, experimental isolation and spectroscopic characterization identified the compositional compounds, ie sambunigrin (1), prunasin (2), uridine (3), and adenosine (4). Secondly, their elucidated structures were predicted with promising bio-chemo-pharmacological potentiality by different computational platforms, ie: docking simulation (docking scores 
      Citation: Natural Product Communications
      PubDate: 2024-08-07T03:13:16Z
      DOI: 10.1177/1934578X241271648
      Issue No: Vol. 19, No. 8 (2024)
       
  • Xanthine Oxidase Inhibitory Activity of Some Vietnamese Remedies Used to
           Treat Bi Syndrome in Traditional Medicine

    • Authors: Duc Phan Nguyen Duong, Chen Van Tran, My-Duyen Thi Chung, Bay Thi Nguyen, Triet Thanh Nguyen
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      BackgroundHyperuricemia is a metabolic disorder caused by abnormalities in purine metabolism that increase serum uric acid. Some traditional medicine remedies have been proven to cause hypouricemia by inhibiting xanthine oxidase. In Vietnam, some remedies that eliminate wind, cold, and dampness have been used to treat gouty arthritis, but there is still a lack of scientific evidence regarding the underlying biological mechanisms involved. This study aimed to assess the xanthine oxidase inhibitory activity in vitro and the hypouricemic effects of several Vietnamese remedies used to treat Bi syndrome in traditional medicine.MethodsThe chosen remedies that met our criteria were successively extracted with 70% ethanol. A preliminary investigation of the chemical composition of the extracts was performed by common chemical reactions. The in vitro xanthine oxidase inhibitory activity of the extracts was investigated using the procedure of Noro et al (1983). Acute toxicology and hypouricemic effect of the remedy that showed the highest xanthine oxidase inhibitory activity were investigated in vivo using a potassium oxonate-induced hyperuricemic mouse model.ResultsFive remedies that met the criteria were chosen. Phytochemical screening of all the extracts revealed the presence of flavonoids, saponins, alkaloids, tannins, and carbohydrates. The Bai nghiem phuong 2 extract did not show xanthine oxidase inhibitory activity whereas the Thang Tri Te Thap extract, which exhibited the highest inhibitory xanthine oxidase activity with an IC50 value of 48.33 ± 0.41 µg/mL, was selected for the subsequent in vivo experiments. The Thang Tri Te Thap extract did not cause acute toxicity, with a Dmax of 31.67 g/kg. At doses of 1.5 g/kg and 3 g/kg, Thang Tri Te Thap significantly reduced the serum uric acid concentration by 59.84 ± 5.79% and 65.01 ± 12.73%, respectively (p 
      Citation: Natural Product Communications
      PubDate: 2024-08-07T03:12:36Z
      DOI: 10.1177/1934578X241269432
      Issue No: Vol. 19, No. 8 (2024)
       
  • Sandwich-Like Complexation of Carbohydrates by Hydrogen Bonding and
           CH-π Interactions

    • Authors: Linda Köhler, Stefan Kaiser, Monika Mazik
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      Introduction: The design of carbohydrate-binding agents (artificial carbohydrate receptors) that enable selective and effective biomimetic recognition via noncovalent interactions is aimed either at a better understanding of natural recognition phenomena or at various potential applications in medicine and other fields. Although very interesting artificial receptors have been developed, the exact prediction of the receptor selectivity remains a challenge. Results and Methods: A molecular architecture based on a 1,3,5-substituted 2,4,6-triethylbenzene backbone bearing two aminopyridine- or aminopyrimidine-based recognition units and a purine moiety, which acts as both a hydrogen bonding site and a bridging component for the incorporation of additional substituents, has proved to be very useful for the development of effective carbohydrate-binding agents. This type of compounds has the ability to bind suitable carbohydrates through combined noncovalent interactions, where CH···π interactions can be formed on both faces of the carbohydrate substrate. The successful syntheses of the target compounds can be realized by the use of microwave irradiation and sealed tubes. The performed binding studies included 1H NMR spectroscopic titrations and measurements by isothermal titration calorimetry. Conclusion: The new compounds were developed as artificial receptors especially for carbohydrates with an all-equatorial substitution pattern and have the ability to predictably form strong 1:1 complexes with a suitable substrate. The use of the purine moiety in the construction of carbohydrate receptors with a 1,3,5-substituted 2,4,6-triethylbenzene backbone has proved to be a very promising approach. The possibilities for structural variation of this molecular architecture are manifold. As a result, a wide range of compounds can be synthesized to perform extensive studies on the relationships between structure and binding efficiency.Graphical AbstractShort Text: New compounds were developed as artificial receptors especially for carbohydrates with an all-equatorial substitution pattern and have the ability to predictably form 1:1 complexes with a suitable substrate.Key Topics: Artificial carbohydrate receptors; Combination of hydrogen bonding and CH۔۔۔π interactions; Molecular recognition
      Citation: Natural Product Communications
      PubDate: 2024-08-07T01:39:26Z
      DOI: 10.1177/1934578X241258352
      Issue No: Vol. 19, No. 8 (2024)
       
  • Anti-Inflammatory and Immunoregulatory Effects of Xiaoqinglong Decoction
           on a Murine Model of Combined Allergic Rhinitis and Asthma Syndrome

    • Authors: Zhao Jingyi, Xinyu Yan, Man Wang, Jinshuai Han, Junge Wang
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      BackgroundXiaoqinglong Decoction (XQLD) is a traditional Chinese medicine formula used for the treatment of allergic rhinitis and asthma, including combined allergic rhinitis and asthma syndrome (CARAS), due to its anti-inflammatory and anti-seizure properties. However, the pharmacological activities and the underlying molecular mechanisms of XQLD remain to be elucidated. Hence, we investigated the effects of XQLD against inflammation in an ovalbumin (OVA)-induced CARAS model in BALB/c mice.MethodsBALB/c mice were sensitized by intraperitoneal injection and aerosol inhalation of OVA. XQLD or dexamethasone was administered by oral gavage prior to OVA challenge for 7 consecutive days. Specific airway resistance (sRAW) was evaluated 24 h after the final challenge with OVA. Enzyme-linked immunosorbent assay was used to measure the levels of serum inflammatory factors. The nasal mucosa and lung tissue were examined for general morphology and goblet hyperplasia using hematoxylin and eosin or periodic acid Schiff staining. Flow cytometry was employed to analyze the frequencies of helper T lymphocytes in peripheral blood. Immunohistochemistry was performed to determine the expression of transcription factors in helper T lymphocytes and γδ TCR.ResultsXQLD significantly ameliorated the symptoms of CARAS model mice, suppressed serum levels of interferon-γ, interleukin (IL)-2, IL-4, IL-5, IL-17, while increasing levels of IL-10, transforming growth factor-β. Epithelium impairment, cilia loss, eosinophil infiltration, and goblet cell metaplasia were significantly reduced in the nasal mucosa and lung tissue sections. XQLD restored the balance of Th1/Th2 and Th17/Treg cell frequency in peripheral blood. Furthermore, XQLD down-modulated the expression of GATA-binding protein 3 (GATA3), retinoic acid receptor-related orphan receptor γt, and γδ T cell receptor (TCR) in the nasal mucosa, along with GATA3 and γδ TCR in the lung tissue.ConclusionsXQLD alleviated OVA-induced CARAS in BALB/c mice through its anti-allergic effects and modulation of the immune system.
      Citation: Natural Product Communications
      PubDate: 2024-08-06T07:45:30Z
      DOI: 10.1177/1934578X241271658
      Issue No: Vol. 19, No. 8 (2024)
       
  • Research on Water-Soluble Constituents and Anti-Aging Effect of the Leaves
           of Nelumbo nucifera Gaertn

    • Authors: Rong-Qian Cheng, Heyanhao Zhang, Jun Chang
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      Objective: This study aimed to isolate and elucidate the structure of water-soluble constituents from Nelumbo nucifera Gaertn. leaves and evaluate their anti-aging effect. Methods: The natural products were isolated from the 60% aqueous acetone extract of the leaves of N. nucifera by column chromatography on MCI gel CHP 20P, YMC-Gel ODS-AQ-HG, and TSK gel Toyopearl HW-40F. Their structures were elucidated using high-resolution-electrospray ionization-mass spectrometry, one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy, and electronic circular dichroism spectroscopy. The anti-aging activity was evaluated in the Caenorhabditis elegans model. Results/Conclusion: One novel flavonoid nuciferanoid (1), together with eleven known compounds, were isolated from the extract of the leaves of N. nucifera. Among them, compound 1 could be a starting point for further development of anti-aging drugs.
      Citation: Natural Product Communications
      PubDate: 2024-08-06T07:44:30Z
      DOI: 10.1177/1934578X241271623
      Issue No: Vol. 19, No. 8 (2024)
       
  • Composition, Skin Pharmacokinetics, and Pharmacological Effects of the
           Sanfu Herbal Patch

    • Authors: Wenqing Li, Ying Lv, Wei Liao, Haibo Jiang, Yuwei Liu, Wenfei Lu, Jiansheng Cao, Yufei Feng
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      The Sanfu herbal patch (SHP) is a traditional Chinese medicine external therapy consisting of Sinapis semen, Asari Radix et Rhizoma, Kansui Radix, and Corydalis Rhizoma. The review involved searching for SHP-related keywords in various databases including Web of Science, PubMed, and China National Knowledge Infrastructure, etc Relevant literature was then selected and findings were summarized. The SHP encompasses a diverse array of bioactive constituents, such as fatty acids, thioglycosides, essential oils, terpenes, alkaloids, and additional chemical compounds. The parent constituents of the SHP that enter skin circulation mainly include sinapine thiocyanate from Sinapis semen, asarinin from Asari Radix et Rhizoma, and tetrahydropalmatine from Corydalis Rhizoma. The SHP exhibits anti-inflammatory, antitussive, analgesic, and antitumor properties, making it a valuable pharmacological agent. Moreover, the SHP is frequently employed in clinical settings to address various ailments including asthma, rhinitis, chronic bronchitis, chronic obstructive pulmonary disease, chronic degenerative joint disease, and chronic gastritis. This review focuses on the main components, skin pharmacokinetics, and pharmacological research progress of the SHP, offering valuable insights for further understanding its mechanism of action and enhancing its clinical application.
      Citation: Natural Product Communications
      PubDate: 2024-08-06T07:44:10Z
      DOI: 10.1177/1934578X241266414
      Issue No: Vol. 19, No. 8 (2024)
       
  • Asiatic Acid, Quercetin, and Kaempferol From Centella asiatica as
           Potential Inhibitors of Alpha-1-Antichymotrypsin in Alzheimer's Disease

    • Authors: Jhinuk Chatterjee, Apoorva Atmuri, Eshaana Janardhan Raichur, Gouri Anil
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      Selected compounds from Centella asiatica with proven neuroprotective potential and analyzed strong binding affinity with molecular docking can be considered as potential inhibitors for alpha-1-antichymotrypsin in Alzheimer's disease.
      Citation: Natural Product Communications
      PubDate: 2024-08-03T07:05:27Z
      DOI: 10.1177/1934578X241264637
      Issue No: Vol. 19, No. 8 (2024)
       
  • SH003 Induces DR5-Mediated Caspase-Dependent Apoptosis of NSCLC Through
           Inhibition of AKT Survival Pathway

    • Authors: Ji Hye Kim, Sooyeon Kang, Gyu-Ri Lee, Seong-Gyu Ko
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      BackgroundTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is well known to selectively induce apoptotic cell death in cancer cells, not in normal cells, with death receptors (DRs)—DR4 and DR5. In consequence of this specialty, this cytokine and its receptors are considered for candidates of target therapy in clinic. SH003, a new traditional medicine-based polyherbal preparation, consists of Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes kirilowii Maximowicz (Tk). In this study, we investigated whether SH003 can induce apoptosis through DRs in non-small-cell lung cancer (NSCLC) cells.MethodsCell proliferation and cytotoxicity were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), clonogenic assay, and, trypan blue exclusion staining, protein expression by western blot analysis, and apoptosis by fluorescence-activated cell sorting analysis.ResultsWe found that SH003-induced apoptosis in NSCLC cells through several mechanisms. First of all, MTT and colony formation assay confirmed the growth-inhibitory effect of SH003 in H460 cells. Second, SH003 upregulated the expression of DR4 and DR5. Third, it activated caspase-8, caspase-7, and caspase-3 cascades, which are essential for DR-mediated extrinsic apoptosis. The effect of SH003-induced apoptosis was significantly abolished by inhibition of caspases enzymes. And also, SH003 cleaved caspse-9. Fourth, SH003 reduced AKT kinase phosphorylation, and overexpression of AKT abrogated the caspase-dependent apoptosis by SH003. Fifth, SH003 inactivated ERK, but, constitutive ERK expression did not completely reduce SH003-mediated growth inhibition and apoptosis.ConclusionsSH003 potentiates caspase-dependent apoptosis of NSCLC through the upregulation of DRs, activation of caspase cascades and downregulation of AKT cell survival pathways.
      Citation: Natural Product Communications
      PubDate: 2024-08-03T07:03:29Z
      DOI: 10.1177/1934578X241265216
      Issue No: Vol. 19, No. 8 (2024)
       
  • Exploring Bioactive Constituents and Pharmacological Effects of
           Scutellaria baicalensis Georgi: A Review

    • Authors: Yan Liu, Zhixu Gao, Yintao Zhao, Lingjuan Kong, Xiaoqing Ji, Jinyang Wu, Zhanhua Gao
      Abstract: Natural Product Communications, Volume 19, Issue 8, August 2024.
      Scutellaria baicalensis, commonly known as Chinese Skullcap, is a traditional herb with a long history of cultural use in Chinese medicines. This review focuses on a comprehensive summary of the morphological description, bioactive compounds, drug-herb interactions, and pharmacological activities of Scutellaria baicalensis, as well as its therapeutic applications. A wide-ranging search using databases such as PubMed, Scopus, Google Scholar, and advanced search on the Web was conducted for data collection from prior studies. The plant root contains major active constituents including flavonoids and flavo-glycosides such as wogonin, baicalein, baicalin, oroxylin A, scutellarein, and norwogonin. These compounds have demonstrated a variety of pharmacological activities, combating inflammation, oxidative stress, cancer, neuronal disorders, and liver disorders. Chinese Skullcap represents a promising avenue for potential pharmacotherapeutic formulation advancement, emphasizing the need for further scientific exploration and clinical trials.
      Citation: Natural Product Communications
      PubDate: 2024-08-03T07:03:00Z
      DOI: 10.1177/1934578X241266692
      Issue No: Vol. 19, No. 8 (2024)
       
 
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