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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted by number of followers
Nature Reviews Drug Discovery     Full-text available via subscription   (Followers: 325)
International Journal of Drug Policy     Hybrid Journal   (Followers: 254)
Journal of Clinical Oncology     Hybrid Journal   (Followers: 239)
Journal of Medicinal Chemistry     Hybrid Journal   (Followers: 154)
Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 152)
Drugs     Full-text available via subscription   (Followers: 143)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 94)
Pharmaceutical Research     Hybrid Journal   (Followers: 93)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 85)
Drug Safety     Full-text available via subscription   (Followers: 81)
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 56)
Biomaterials     Hybrid Journal   (Followers: 55)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 45)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 41)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 38)
Journal of Controlled Release     Hybrid Journal   (Followers: 37)
International Journal of Pharmaceutics     Hybrid Journal   (Followers: 37)
Clinical Therapeutics     Hybrid Journal   (Followers: 34)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 34)
Pharmacoepidemiology and Drug Safety     Hybrid Journal   (Followers: 33)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 31)
Journal of Pharmacy and Pharmacology     Full-text available via subscription   (Followers: 31)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 29)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 28)
PharmacoEconomics     Full-text available via subscription   (Followers: 26)
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 25)
AAPS Journal     Hybrid Journal   (Followers: 25)
Journal of Clinical Psychopharmacology     Hybrid Journal   (Followers: 24)
International Journal of Pharmacy Practice     Full-text available via subscription   (Followers: 24)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 24)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 22)
Journal of Pharmacokinetics and Pharmacodynamics     Hybrid Journal   (Followers: 22)
Journal of Pain & Palliative Care Pharmacotherapy     Hybrid Journal   (Followers: 21)
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 20)
Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 20)
Journal of Applied Toxicology     Hybrid Journal   (Followers: 19)
Pharmaceutical Development and Technology     Hybrid Journal   (Followers: 19)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 19)
Clinical Trials     Hybrid Journal   (Followers: 18)
Toxicology     Hybrid Journal   (Followers: 18)
Journal of Pharmaceutical and Biomedical Analysis     Hybrid Journal   (Followers: 18)
Clinical Toxicology     Hybrid Journal   (Followers: 18)
International Journal of Toxicology     Hybrid Journal   (Followers: 17)
Journal of Clinical Pharmacy and Therapeutics     Hybrid Journal   (Followers: 17)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Journal of Natural Products     Hybrid Journal   (Followers: 16)
Pharmaceutical Statistics     Hybrid Journal   (Followers: 15)
Toxicology Letters     Hybrid Journal   (Followers: 15)
Journal of Pharmacy Practice     Hybrid Journal   (Followers: 15)
Psychopharmacology     Hybrid Journal   (Followers: 15)
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 14)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 14)
Current Medicinal Chemistry     Hybrid Journal   (Followers: 13)
American Journal of Therapeutics     Hybrid Journal   (Followers: 13)
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 13)
Journal of the American Pharmacists Association     Full-text available via subscription   (Followers: 13)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 13)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 12)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 12)
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Journal of Oncology Pharmacy Practice     Hybrid Journal   (Followers: 12)
Journal of Psychopharmacology     Hybrid Journal   (Followers: 11)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 11)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 11)
Drug Development Research     Hybrid Journal   (Followers: 11)
Toxicology in Vitro     Hybrid Journal   (Followers: 11)
Seminars in Oncology Nursing     Full-text available via subscription   (Followers: 10)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Journal of Pharmacology and Experimental Therapeutics     Hybrid Journal   (Followers: 10)
Journal of Separation Science     Hybrid Journal   (Followers: 10)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 10)
Journal of Medical Marketing     Hybrid Journal   (Followers: 10)
Drugs & Aging     Full-text available via subscription   (Followers: 10)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 9)
Food Additives & Contaminants Part A     Hybrid Journal   (Followers: 9)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 9)
Medicinal Chemistry     Hybrid Journal   (Followers: 9)
Biometrical Journal     Hybrid Journal   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Prescriber     Hybrid Journal   (Followers: 9)
ChemMedChem     Hybrid Journal   (Followers: 9)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 9)
European Journal of Pharmacology     Hybrid Journal   (Followers: 8)
Clinical Drug Investigation     Full-text available via subscription   (Followers: 8)
Inhalation Toxicology     Hybrid Journal   (Followers: 8)
Antiviral Research     Hybrid Journal   (Followers: 8)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 8)
Progress in Neuro-Psychopharmacology and Biological Psychiatry     Hybrid Journal   (Followers: 8)
Human & Experimental Toxicology     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 8)
BioDrugs     Full-text available via subscription   (Followers: 8)
Frontiers in Drug Design & Discovery     Hybrid Journal   (Followers: 8)
Expert Review of Pharmacoeconomics & Outcomes Research     Full-text available via subscription   (Followers: 8)
Experimental and Clinical Psychopharmacology     Full-text available via subscription   (Followers: 7)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 7)
Journal of Pharmacological and Toxicological Methods     Hybrid Journal   (Followers: 7)
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 7)
Scandinavian Journal of Clinical and Laboratory Investigation     Hybrid Journal   (Followers: 7)
Epilepsy Research     Hybrid Journal   (Followers: 7)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Journal of Veterinary Pharmacology and Therapeutics     Hybrid Journal   (Followers: 6)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 6)
Journal of Cardiovascular Pharmacology     Hybrid Journal   (Followers: 6)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 6)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Therapeutic Research     Open Access   (Followers: 6)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 6)
Neuropharmacology     Hybrid Journal   (Followers: 5)
Current Drug Metabolism     Hybrid Journal   (Followers: 5)
Fitoterapia     Hybrid Journal   (Followers: 5)
Expert Review of Molecular Diagnostics     Full-text available via subscription   (Followers: 5)
Expert Review of Anti-infective Therapy     Full-text available via subscription   (Followers: 5)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Toxicon     Hybrid Journal   (Followers: 5)
Medicinal Research Reviews     Hybrid Journal   (Followers: 5)
Investigational New Drugs     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 5)
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Reviews of Physiology, Biochemistry and Pharmacology     Hybrid Journal   (Followers: 4)
Planta Medica     Hybrid Journal   (Followers: 4)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 4)
Pharmaceutical Medicine     Full-text available via subscription   (Followers: 4)
Journal of Child and Adolescent Psychopharmacology     Hybrid Journal   (Followers: 4)
CNS Drug Reviews     Open Access   (Followers: 4)
Inpharma Weekly     Full-text available via subscription   (Followers: 4)
Journal of Labelled Compounds and Radiopharmaceuticals     Hybrid Journal   (Followers: 4)
Immunopharmacology and Immunotoxicology     Hybrid Journal   (Followers: 4)
International Journal of Pharmaceutical and Healthcare Marketing     Hybrid Journal   (Followers: 4)
Inflammation Research     Hybrid Journal   (Followers: 4)
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
International Journal of Neuropsychopharmacology     Open Access   (Followers: 3)
Pharmacology & Therapeutics     Hybrid Journal   (Followers: 3)
Physiology International     Full-text available via subscription   (Followers: 3)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Pharmacopsychiatry     Hybrid Journal   (Followers: 3)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Therapeutic Drug Monitoring     Hybrid Journal   (Followers: 3)
Current Drug Therapy     Hybrid Journal   (Followers: 3)
Research in Social and Administrative Pharmacy     Hybrid Journal   (Followers: 3)
PharmacoEconomics & Outcomes News     Full-text available via subscription   (Followers: 3)
Journal of Aerosol Medicine and Pulmonary Drug Delivery     Hybrid Journal   (Followers: 3)
Journal of Ethnopharmacology     Hybrid Journal   (Followers: 3)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Journal of Infection and Chemotherapy     Hybrid Journal   (Followers: 3)
Journal of Cardiovascular Pharmacology and Therapeutics     Hybrid Journal   (Followers: 3)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 3)
Microbial Drug Resistance     Hybrid Journal   (Followers: 3)
Frontiers in Medicinal Chemistry     Hybrid Journal   (Followers: 3)
Human Psychopharmacology Clinical and Experimental     Hybrid Journal   (Followers: 3)
Journal of Pain Management & Medicine     Open Access   (Followers: 2)
BMC Pharmacology     Open Access   (Followers: 2)
The Brown University Psychopharmacology Update     Hybrid Journal   (Followers: 2)
International Clinical Psychopharmacology     Hybrid Journal   (Followers: 2)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 2)
Journal of Drug Targeting     Hybrid Journal   (Followers: 2)
Inflammopharmacology     Hybrid Journal   (Followers: 2)
Journal of Inflammation     Open Access   (Followers: 2)
Fundamental & Clinical Pharmacology     Hybrid Journal   (Followers: 2)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Vascular Pharmacology     Hybrid Journal   (Followers: 2)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Drugs in R & D     Full-text available via subscription   (Followers: 2)
International Immunopharmacology     Hybrid Journal   (Followers: 2)
Pharmacology Biochemistry and Behavior     Hybrid Journal   (Followers: 2)
Letters in Drug Design & Discovery     Hybrid Journal   (Followers: 2)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Pharmacological Reviews     Hybrid Journal   (Followers: 2)
Molecular Pharmacology     Hybrid Journal   (Followers: 2)
Journal of Microencapsulation: Microcapsules, Liposomes, Nanoparticles, Microcells, Microspheres     Hybrid Journal   (Followers: 2)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Particulate Science and Technology: An International Journal     Hybrid Journal   (Followers: 1)
Pharmacological Research     Hybrid Journal   (Followers: 1)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Journal of Neuroimmune Pharmacology     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Pharmacogenetics and Genomics     Hybrid Journal   (Followers: 1)
Journal of Texture Studies     Hybrid Journal   (Followers: 1)
Pharmaceutical Biology     Open Access  
Journal of Liposome Research     Hybrid Journal  
Toxin Reviews     Hybrid Journal  
Kaohsiung Journal of Medical Sciences     Open Access  
Redox Report     Open Access  
Pharmacology     Full-text available via subscription  
Pharmaceutical Chemistry Journal     Hybrid Journal  
NeuroMolecular Medicine     Hybrid Journal  
Journal of Ocular Pharmacology and Therapeutics     Hybrid Journal  
Harm Reduction Journal     Open Access  
Current Nanoscience     Hybrid Journal  
Infectious Disorders - Drug Targets     Hybrid Journal  
Current Bioactive Compounds     Hybrid Journal  
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Autonomic & Autacoid Pharmacology     Hybrid Journal  

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Natural Product Communications
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1934-578X - ISSN (Online) 1555-9475
Published by Sage Publications Homepage  [1174 journals]
  • Rutin Suppresses DMBA Carcinogenesis in the Breast Through Modulating
           IL-6/NF-κB, SRC1/HSP90 and ER-α

    • Authors: Seham S M Youssef, Nashwa K Ibrahim, Sawsan M El-Sonbaty, Magda K El-Din Ezz
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Rutin dietary supplements may offer pharmacological benefits as anticancer and antiinflammatory properties. This study aimed to investigate the inhibitory and protective effect of rutin on signaling pathways of mammary gland carcinogenesis expermintally induced in female rats by 7,12-di-methyl benz (a) anthracene (DMBA). Results showed that rutin administration ameliorated DMBA toxicity and carcinogic effect on kidney and liver revealed by a significant decrease of urea and creatinine levels, and the activity of the liver enzymes alanine aminotransferase (ALT) and alkaline phosphatase (ALP). The antioxidant state indicated by the total antioxidant capacity (TAC) was significantly increased accompanied by a reduction in the inflammatory markers of interleukin-1β (IL-1B), interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) with induction of apoptosis indicated by a significant increase in caspase-3 level. Rutin significantly reduced the levels of the tumor markers carcinoma antigen 15-3 (CA 15-3) and proto-oncogene tyrosine-protein kinase Src1 (Src1). along with downregulation of nuclear factor-kB (NF-κB), heat shock protein 90 (HSP 90), and inducible nitric oxide synthase (iNOS) gene expression. The present study demonstrated the beneficial anticancer activity of rutin as a protective and therapeutic agent. Rutin induces its antitumor activity through elevation of the antioxidant state, inhibition of inflammatory cytokines, downregulation of oncogenes expression, and stimulation of apoptosis.
      Citation: Natural Product Communications
      PubDate: 2022-09-23T11:10:59Z
      DOI: 10.1177/1934578X221118213
      Issue No: Vol. 17, No. 9 (2022)
  • Vanillic Acid Attenuates Monocrotaline-Induced Pulmonary Arterial
           Hypertension by Enhancing NO Signaling Pathways

    • Authors: Shan Wang, Xuyang Sun, Zhuguo Wang, Shengjin Zhou, Shanshan Su, Xingmei Nan, Dianxiang Lu, Zhanqiang Li
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Pulmonary arterial hypertension (PAH) is a severe progressive disease characterized by elevated mean pulmonary arterial pressure, right ventricular hypertrophy, and eventual progression to right heart failure and death. This study aimed to examine the effect of the natural product vanillic acid (VA) on monocrotaline (MCT)-induced PAH in rats. The arginase inhibitory activity and enzyme kinetic reaction of VA were also investigated. The results showed that VA could improve pulmonary arterial pressure, pulmonary artery vascular remodeling, and right ventricular remodeling induced by MCT in rats and reduce the degree of pulmonary tissue fibrosis. Moreover, VA downregulated the gene and protein expression levels of Hif-2α, Hif-1β, and Arg2 and increased the P-eNOS/eNOS levels, thus increasing nitric oxide (NO) levels in PAH rats. Furthermore, VA was determined to be a mixed competitive arginase inhibitor with an IC50 of 26.1 μM. In conclusion, the arginase inhibitor VA exerted protective effects on MCT-induced PAH and pulmonary vascular remodeling by enhancing NO signaling pathways.
      Citation: Natural Product Communications
      PubDate: 2022-09-23T06:31:09Z
      DOI: 10.1177/1934578X221128411
      Issue No: Vol. 17, No. 9 (2022)
  • A Study on the Mechanism of Herbal Drug FDY003 for Colorectal Cancer
           Treatment by Employing Network Pharmacology

    • Authors: Ho-Sung Lee, In-Hee Lee, Sang-In Park, Minho Jung, Seung Gu Yang, Tae-Wook Kwon, Dae-Yeon Lee
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Colorectal cancer (CRC) originates from the uncontrolled growth of epithelial cells in the colon or rectum. Annually, 1.9 million new CRC cases are being reported, causing 0.9 million deaths worldwide. The suppressive effects of the herbal prescription FDY003, a mixture of Cordyceps militaris, Lonicera japonica Thunberg, and Artemisia capillaris Thunberg, against CRC have previously been reported. Nonetheless, the multiple compound-multiple target mechanisms of FDY003 in CRC cells have not been fully elucidated. In this study, we used network pharmacology (NP) to analyze the polypharmacological mechanisms of action of FDY003 in CRC treatment. FDY003 promoted the suppression of viability of CRC cells and strengthened their sensitivity to anticancer drugs. The NP study enabled the investigation of 17 pharmaceutical compounds and 90 CRC-related genes that were targets of the compounds. The gene ontology terms enriched with the CRC-related target genes of FDY003 were those involved in the control of a variety of phenotypes of CRC cells, for instance, the decision of apoptosis and survival, growth, stress response, and chemical response of cells. In addition, the targeted genes of FDY003 were further enriched in various Kyoto Encyclopedia of Genes and Genomes pathways that coordinate crucial pathological processes of CRC; these are ErbB, focal adhesion, HIF-1, IL-17, MAPK, PD-L1/PD-1, PI3K-Akt, Ras, TNF, and VEGF pathways. The overall analysis results obtained from the NP methodology support the multiple-compound-multiple-target-multiple-pathway pharmacological features of FDY003 as a potential agent for CRC treatment.
      Citation: Natural Product Communications
      PubDate: 2022-09-22T04:57:54Z
      DOI: 10.1177/1934578X221126964
      Issue No: Vol. 17, No. 9 (2022)
  • Therapeutic Options for the SARS-CoV-2 Virus: Is There a Key in Herbal

    • Authors: Nitin Sharma, Giriraj T. Kulkarni, Anant Narayan Bhatt, Saurabh Satija, Lubhan Singh, Anjana Sharma, Kamal Dua, Ritu Karwasra, Asim Ali Khan, Nadeem Ahmad, Khalid Raza
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      SARS-CoV-2 has been responsible for over 500 million cumulative cases all over the world since December 2019 and has marked the third introduction of a highly pathogenic virus after SARS-CoV and MERS-CoV. This virus is in a winning situation because scientists are still racing to explore effective therapeutics, vaccines, and event treatment regimens. In view of progress in current disease management, until now none of the preventive/treatment measures can be considered entirely effective to treat SARS-CoV-2 infection. Therefore, it is required to look up substitute ways for the management of this disease. In this context, herbal medicines could be a good choice. This article emphasizes the antiviral potential of some herbal constituents which further can be a drug of choice in SARS-CoV-2 treatment. This article may be a ready reference for discovering natural lead compounds and targets in SARS-CoV-2 associated works.
      Citation: Natural Product Communications
      PubDate: 2022-09-22T04:57:34Z
      DOI: 10.1177/1934578X221126303
      Issue No: Vol. 17, No. 9 (2022)
  • Anti-Inflammatory Effects of Aralia elata Extract Against Dextran Sodium
           Sulfate-Induced Colitis in Mice and Raw 264.7 Macrophage Cells Exposed to
           Lipopolysaccharide: First Report

    • Authors: Euiyong Lee, Se-Won Lee, Gareeballah Osman Adam, Yeo-Jin Yoo, Ha-Young Shin, Dongchoon Ahn, Tae-Hu Jang, Byung-Taek Oh, Byung-Yong Park, In-Shik Kim, Seung Hyun Lee, Jeong Ho Lee, Hyun-Jin Tae
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Aralia elata (AE) is an anti-inflammatory, polyphenolic containing medicinal plant. However, little is known about AE and its application to ulcerative colitis (UC). This study aimed to confirm AE extract's antioxidant and anti-inflammatory effects in vivo and in vitro. The in vitro antioxidant activity was evaluated by measuring total polyphenol and flavonoid content in AE extract. AE extract (10 000 mg/L) contained 186.8 mg GAE/g polyphenol and 81.9 mg QE/g flavonoid. Mice were divided into 6 groups, including control, which received normal saline, and treatment groups, which received dextran sodium sulfate (DSS) with or without AE extract (250, 500, and 1000 mg/kg). RAW 264.7 macrophage cells were divided into 2 groups: control and treatment. RAW 264.7 macrophage cells treated with sterile double distilled water, 1 mg/L lipopolysaccharide (LPS), and AE extracts (25, 50, 75, 100 µg/mL) were used to assess the cytotoxicity and anti-inflammatory activity. High-performance liquid chromatography, enzyme-linked immunosorbent assay (ELISA) kits, and histology were employed to analyze the AE extract contents, nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6, as oxidative stress markers. In addition, the disease activity index (DAI) and cytotoxicity were determined in mice and cells, respectively. High-performance liquid chromatography analysis revealed that AE extract is rich in chlorogenic acid (96 ± 0.01 mg/g). DSS increased the DAI and levels of TNF-α, IL-1β, and immune cell infiltration compared with those of the control animals. Furthermore, LPS eventually reduced cell viability and increased the levels of NO, TNF-α, IL-1β, and IL-6 in contrast to control cells. After treatment, a noticeable reduction was observed in the levels of DAI, NO, TNF-α, IL-1β, and IL-6 compared to those without AE treatments. Overall, AE extract is safe and had anti-inflammatory properties. Therefore, AE extract can be considered a potential pre-treatment supplement for UC.
      Citation: Natural Product Communications
      PubDate: 2022-09-22T04:57:14Z
      DOI: 10.1177/1934578X221126047
      Issue No: Vol. 17, No. 9 (2022)
  • Two New Abietane Diterpenes From the Stems of Clerodendrum trichotomum

    • Authors: Lin-Zhen Li, Yu Zhang, Liang Chen, Yin-Zhi Cen, Yang-Li Tu, Xiao-Sheng Yang, Yong-Jun Li
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Two new abietane diterpenoids (4S, 5S, 10S)-12-(β-D-glucopyranosyl)oxy-11-hydroxyabieta-8,11,13-triene-19-oic acid β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (1) and (3S, 5S, 10S, 15S)-3β-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]oxy-12-(β-D-glucopyranosyl)oxyabieta-8,11,13-triene-11,16-diol (2), along with 5 known terpene glycosides (3–7) were isolated from the n-butanol extract of the stems of Clerodendrum trichotomum Thunb. The structures of the new compounds were determined by analysis of spectroscopic data, chemical correlations, and electronic circular dichroism calculations. Besides, all compounds were evaluated for cytotoxic activities against cultured K562, MCF-7, A549, and HepG2 cell lines. None of them showed good antitumor activities.
      Citation: Natural Product Communications
      PubDate: 2022-09-21T08:58:35Z
      DOI: 10.1177/1934578X221125053
      Issue No: Vol. 17, No. 9 (2022)
  • Experimental Study on the Inhibition of Bacteria and Algae by Jussiaea
           stipulacea Ohwi Extract

    • Authors: Yulu Shi, Yao Zheng, Xuwen Bing, Julin Yuan
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Nowadays, plant allelopathy, as a new type of biological algal and/or bacterial inhibition technology, has attracted extensive attention. Eight substances were isolated and identified from Jussiaea stipulacea Ohwi, and five concentration gradients, as well as a control (0, 1.25, 5, 10, 20, and 50 mg/L) were set, with three parallels in each group, and then sampled and detected at 24, 48, 72, and 96 h. When the concentration was 50 mg/L, the inhibition rate of Anabaena was as high as 74.8%, 69.2%, and 70.7% for ursolic acid, kaempferol, and luteolin, respectively. Streptococcus iniae and Aeromonas hydrophila were cultured to a logarithmic phase, and their final concentrations reached 1000, 500, 250, 125, 62.50, 31.25, 15.63, and 7.81 μg/mL. Luteolin and gallic acid showed an inhibitory effect on S iniae and A hydrophila at 1000 μg/mL. We found that allelochemicals also had a certain bacteriostatic effect, among which luteolin has great development potential.
      Citation: Natural Product Communications
      PubDate: 2022-09-17T05:00:36Z
      DOI: 10.1177/1934578X221124775
      Issue No: Vol. 17, No. 9 (2022)
  • Mechanistic Prediction of Chinese Herb Compound (Zhi Zhu Ma Ren Pill) in
           the Treatment of Constipation Using Network Pharmacology and Molecular

    • Authors: Yong Wen, Yu Zhan, Shiyu Tang, Jian Kang, Rong Wu, Xuegui Tang
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Background: Constipation is one of the most prevalent chronic gastrointestinal diseases. Notably, previous studies have demonstrated that Chinese herbal compounds may exert effects on constipation. The present study aimed to predict the mechanisms underlying the effects of Zhi Zhu Ma Ren Pill (ZZMRP), which includes Aurantii Fructus Immaturus, Atractylodis Macrocephalae Rhizoma, Fructus Cannabis, Paeonia lactiflora and Radix Asteris in the treatment of constipation, using network pharmacology and molecular docking. Methods: The components and target information of ZZMRP were accessed using the Traditional Chinese Medicine Systems Pharmacology database and analysis platform, and the associated targets of constipation were obtained from the GeneCards, Disgenet, Online Mendelian Inheritance in Man, DrugBANK and Therapeutic Target Database databases. The major targets were subsequently selected using a Venn diagram and network topology analysis, which was followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Molecular docking was performed to authenticate the binding activity between active components and core targets. Results: A total of 44 active components, 249 targets of ZZMRP and 1501 targets associated with constipation were acquired. A total of 122 intersection targets were discovered between ZZMRP and constipation. Subsequently, 18 key targets were authenticated, including tumor protein 53, RAC-alpha serine/threonine-protein kinase, JUN and caspase-3. GO and KEGG pathway enrichment analysis indicated that mitogen-activated protein kinase, tumor necrosis factor, and phosphoinositide 3-kinase/protein kinase B signaling pathways may be involved in the treatment of constipation using ZZMRP. Molecular docking suggested that quercetin, kaempferol, and luteolin exhibited high binding affinities with several of the primary targets. Conclusions: The active components, core targets, and signaling pathways of ZZMRP in the treatment of constipation were predicted, which may be applicable to the development of treatments for constipation and application of ZZMRP.
      Citation: Natural Product Communications
      PubDate: 2022-09-15T12:33:24Z
      DOI: 10.1177/1934578X221124780
      Issue No: Vol. 17, No. 9 (2022)
  • Volatile Constituents and Anti-Osteoporotic Activity of the n-Hexane
           Extract From Homalomena gigantea Rhizome

    • Authors: Ty Viet Pham, Hang Phuong Thi Ngo, Nhan Thi Thanh Dang, Hien Khoa Nguyen, Hanh Thi Nhu Hoang, Thanh Pham
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      This study analyzed the chemical composition and anti-osteoporosis activity of the n-hexane extract of Homalomena gigantea rhizome. Sixty compounds, representing 92.0% of the extract, were identified by gas chromatography-mass spectrometry. Linalool (15.3%), oplopanone (9.8%), (Ε)-α-atlantone (5.6%), khusinol acetate (5.4%), bullatantriol (4.3%), and β-sitosterol (3.8%) were the main constituents. The anti-osteoporotic activity of the n-hexane extract was determined by measuring alkaline phosphatase (ALP) activity, collagen content, and the mineralization of MC3T3-E1 cells. At concentrations of 4.0 and 20.0 µg/mL, the n-hexane extract increased ALP activity by 8.2% and 23.7%, and increased collagen secretion by MC3T3-E1 cells by 114.9% and 112.4%, respectively. At 4 µg/mL, the extract significantly promoted the mineralization of MC3T3-E1 cells by as much as 133.2% compared to the negative control. These results suggested that H. gigantea rhizome contains a natural anti-osteoporotic compound.
      Citation: Natural Product Communications
      PubDate: 2022-09-14T05:59:52Z
      DOI: 10.1177/1934578X221125433
      Issue No: Vol. 17, No. 9 (2022)
  • Honokiol Improves Acne-like Lesions in a Rabbit Ear Model by Alleviating
           Hyperkeratosis and Sebum Secretion

    • Authors: Yuyan Zhu, Lixia Zhang, Xiyuan Zhou
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      The prevalence of acne vulgaris is high, but the topical retinoids used as the foundation of treatment have teratogenic and photosensitivity properties. Previous studies have suggested that honokiol, a small-molecule compound extracted from Magnolia officinalis, could effectively inhibit Cutibacterium acnes (C acnes) and inflammation in vitro. However, the effect in vivo is unclear. The rabbit ear acne model that we created showed obvious comedones and hyperkeratosis. These lesions were repeatedly measured and recorded by dermatoscopy (ultraviolet light). Compared with the control group, topical 2.5% honokiol cream obviously improved the comedones and hyperkeratosis and effectively reduced sebum secretion, as shown by Oil Red O staining. The effects were equivalent to those of adapalene gel without local side effects. We added honokiol's other functions to acne treatment in addition to antiinflammation, but further studies are needed.
      Citation: Natural Product Communications
      PubDate: 2022-09-14T05:12:07Z
      DOI: 10.1177/1934578X221126369
      Issue No: Vol. 17, No. 9 (2022)
  • Unveiling the Mechanism of the Traditional Korean Medicinal Formula FDY003
           on Glioblastoma Through a Computational Network Pharmacology Approach

    • Authors: Ho-Sung Lee, In-Hee Lee, Sang-In Park, Minho Jung, Seung Gu Yang, Tae-Wook Kwon, Dae-Yeon Lee
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Glioblastoma (GBM) is the most common type of primary malignant tumor that develops in the brain, with 0.21 million new cases per year globally and a median survival period of less than 2 years after diagnosis. Traditional Korean medicines have been increasingly suggested as effective and safe therapeutic strategies for GBM. However, their pharmacological effects and mechanistic characteristics remain to be studied. In this study, we employed a computational network pharmacological approach to determine the effects and mechanisms of the traditional Korean medicinal formula FDY003 on GBM. We found that FDY003 treatment decreased the viability of human GBM cells and increased their response to chemotherapeutics. We identified 10 potential active pharmacological compounds of FDY003 and 67 potential GBM-related target genes and proteins. The GBM-related targets of FDY003 were signaling components of various crucial GBM-associated pathways, such as PI3K-Akt, focal adhesion, MAPK, HIF-1, FoxO, Ras, and TNF. These pathways are functional regulators for the determination of cell growth and proliferation, survival and death, and cell division cycle of GBM cells. Together, the overall analyses contribute to the pharmacological basis for the anti-GBM roles of FDY003 and its systematic mechanisms.
      Citation: Natural Product Communications
      PubDate: 2022-09-14T05:11:45Z
      DOI: 10.1177/1934578X221126311
      Issue No: Vol. 17, No. 9 (2022)
  • Three New Glycosides From the Stems of Derris elliptica

    • Authors: Bui Thi Thu Trang, Nguyen Xuan Nhiem, Nguyen Thi Huong, Nguyen Thi Thanh Mai, Nguyen Tuan Anh, Phan Van Kiem
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Three new glycosides, derriacuminosides A-C (1-3), were isolated from the stems of Derris elliptica (Wall.) Benth. Their chemical structures were determined by interpretations of HRESIMS and NMR spectra. The anti-inflammatory activity of compounds 1-3 were evaluated by inhibiting NO production in LPS activated RAW264.7 cells. Compounds 1-3 potentially inhibited NO production with IC50 values of 26.54 ± 3.08, 26.35 ± 1.37, and 49.71 ± 2.93 µM, respectively, compared to the positive control, L-NMMA (IC50 35.56 ± 2.98 µM).
      Citation: Natural Product Communications
      PubDate: 2022-09-14T05:11:07Z
      DOI: 10.1177/1934578X221126299
      Issue No: Vol. 17, No. 9 (2022)
  • Synthesis, Antioxidant, and Antihypoxia Activities of
           6,7,8,4′-Tetrahydroxyisoflavone and

    • Authors: Hongqiang Tan, Jin Shao, Jie Zhang, Huiping Ma, Linlin Jing
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      In the present study, 6,8-dihydroxydaidzein (6,8-DHD or 6,7,8,4′-tetrahydroxyisoflavone) and 6,8,3′-trihydroxydaidzein (6,8,3′-THD or 6,7,8,3′,4′-pentahydroxyisoflavone) were synthesized via a facile and efficient way using commercially available formononetin as starting material. Their structures were confirmed using spectroscopic analyses (infrared, nuclear magnetic resonance, and mass spectrometry). The purity was checked by ultra-high performance liquid chromatography. Their antioxidant activities were evaluated via 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay and reducing power assay using ascorbic acid (vitamin C) as a reference compound. The antihypoxia capacity was determined by a hypoxia injury model in PC12 cells. Our study revealed that 6,8-DHD and 6,8,3′-THD exhibited higher antioxidant activities than that of vitamin C and could protect PC12 cells against hypoxia-induced damage. These results indicate that 6,8-DHD and 6,8,3′-THD are excellent antioxidant agents and could be used for alleviating injury induced by hypoxia.
      Citation: Natural Product Communications
      PubDate: 2022-09-14T05:10:27Z
      DOI: 10.1177/1934578X221126042
      Issue No: Vol. 17, No. 9 (2022)
  • Tissue Culture of Plagiochasma appendiculatum and the Effect of Callus
           Differentiation on Types and Content of Bisbibenzyls

    • Authors: Yu Zhao, Xuesen Wen, Rong Ni, Aixia Cheng, Hongxiang Lou
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Plagiochasma appendiculatum, a thalloid liverwort, contains high levels of bisbibenzyls, aromatic compounds with potent antitumor as well as antifungal activities. In the present study, rapid growth callus was induced from the thallus of P. appendiculatum, and optimal culture conditions, including medium, temperature, pH, and plant growth regulators for callus production were evaluated. Under optimal culture conditions, the biomass of the callus doubled with a sigmoidal growth curve after 15 days. Differentiation and plant regeneration were studied on a medium supplemented with different plant hormones (α-naphthaleneacetic acid [NAA], 6-benzyladenine [6-BA], and 2,4-dichlorophenoxyacetic acid [2,4-D]). NAA and 6-BA stimulated rhizoid and thallus differentiation, respectively, whereas 2,4-D inhibited the differentiation of thallus and rhizoid. Different metabolic profiles of callus, differentiated thallus, and thallus in the soil were studied by high-performance liquid chromatography. The results showed that both the callus and thallus could synthesize bisbibenzyls. In addition, the kinds and content of bisbibenzyl differed significantly between the callus and thallus. In conclusion, P. appendiculatum thallus cultured in vitro possesses the ability to biosynthesize bisbibenzyl, and it may be utilized for the mass production of specific bisbibenzyls in an appropriate growth environment.
      Citation: Natural Product Communications
      PubDate: 2022-09-14T05:09:37Z
      DOI: 10.1177/1934578X221106243
      Issue No: Vol. 17, No. 9 (2022)
  • Amyloid Polypeptide Disaggregation Activity of Passion Fruit Seed-Derived
           Polyphenol Compounds

    • Authors: Tatsuya Sampei, Yingxue Wu, Hideyuki Shigemori
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      In an aging society, the prevalence of Alzheimer disease (AD) and type 2 diabetes (T2D) has increased. It is currently hypothesized that these diseases are caused by the aggregation of amyloid β (Aβ) in the brain and human islet amyloid polypeptide (hIAPP) in the islets of Langerhans, respectively. Therefore, the disaggregation of these existing amyloid aggregates is a promising approach to the prevention and treatment of both diseases. In our previous studies, we found a remarkable Aβ and hIAPP aggregation inhibitory activity of polyphenolic compounds containing catechol moieties. Compared to previous reports on their aggregation inhibitory activity, there are few on the disaggregation activity of polyphenolic compounds. Additionally, there are few findings on the disaggregation activity of polyphenolic compounds on hIAPP. In this study, we investigated the Aβ and hIAPP disaggregation activity of scirpusin B, a polyphenolic compound found in passion fruit seeds, and related compounds. Thioflavin T (Th-T) assays and transmission electron microscopy (TEM) were performed on these compounds to evaluate their Aβ42 and hIAPP disaggregation activities. The results showed that scirpusin B and its related compounds showed remarkable disaggregation activity. The structure–activity relationship of these compounds revealed that the presence of catechol moieties is important for this activity. This study also showed that polyphenols from passion fruit seeds have significant disaggregation activity against amyloid polypeptide aggregation.
      Citation: Natural Product Communications
      PubDate: 2022-09-14T05:09:07Z
      DOI: 10.1177/1934578X221092710
      Issue No: Vol. 17, No. 9 (2022)
  • Antitobacco Mosaic Virus Activity of a New Eremophilane Glucoside From the
           Leaves of Nicotiana tabacum L

    • Authors: Hui Wang, Li-li Zhang, Yong-sheng Li, Shi-tou Li, Wen-miao He, Ji-zhong Wu, Yi-ming Bi, Lu Dai, Meng-hao Shen, Jing Yang, Jin-xin Tie
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      A new eremophilane-type sesquiterpene glucoside, 13-hydroxycapsidiol 3-O-β-D-glucoside (1), was isolated from the leaves of Nicotiana tabacum L. The structure of this new metabolite was determined by one-dimensional (1D) and 2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and comparison with values reported in the literature. Compound 1 was the second glycosylated eremophilane sesquiterpenoid isolated from plants of the Solanaceae family and exhibited a more potent anti-tobacco mosaic virus (anti-TMV) activity, with an inhibition rate of 39.4% at 20 μM, than the positive control ningnanmycin (34.8%).
      Citation: Natural Product Communications
      PubDate: 2022-09-13T02:53:40Z
      DOI: 10.1177/1934578X221120216
      Issue No: Vol. 17, No. 9 (2022)
  • Investigating the Potential Bioactive Components of Qing-Fei-Pai-Du
           Decoction Against COVID-19 in Diabetes/Diabetic Patients Based on Network
           Pharmacology and Molecular Docking

    • Authors: Yang Liu, Huilian Huang
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      The network pharmacological regulation mechanism has been studied in which Qing-Fei-Pai-Du Decoction (QFPDD) can be used for treating diabetic patients suffering from coronavirus disease 2019 (COVID-19). In this study, we retrieved the target genes of QFPDD along with its effective components from the Traditional Chinese medicine systems pharmacology database. The target genes of diabetes and COVID-19-associated diseases were searched based on the GeneCards database, and the co-target genes of QFPDD were obtained. The target genes were analyzed using the Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. Cytoscape software was used for constructing the “herb-ingredient-target” network. Then, the co-target genes were imported into the Metascape database to analyze protein–protein interaction. Based on the results of the analysis of the hub genes from each database, the key target genes and the active components of QFPDD effective for treating diabetic COVID-19 patients were obtained. The crystal structures of the key target genes were retrieved from the protein data bank database, and molecular docking (MD) was performed using the AutoDock Tool, PyMoL, Chen3D, and other software. In total, 305 active ingredients and 274 target genes were identified among 19 traditional Chinese medicines present in QFPDD. We found 4585 COVID-19 target genes, 16 660 diabetes target genes, and 60 drug-disease target genes. The results of the Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses showed that the main function of these co-target genes was immune regulation. Additionally, protein interaction analysis and cluster analysis were performed to obtain a protein interaction network, and 3 core proteins and 4 core active components were found. According to the results of MD, the main effective components (quercetin, kaempferol, and wogonin) present in QFPDD were found to bind strongly to the receptor. The main active components of QFPDD were effective in treating diabetes complicated with COVID-19 through their actions on multiple biological pathways.
      Citation: Natural Product Communications
      PubDate: 2022-09-09T12:05:39Z
      DOI: 10.1177/1934578X221124769
      Issue No: Vol. 17, No. 9 (2022)
  • Cytotoxic Biflavonoids from Selaginella braunii

    • Authors: Xue-Feng Liu, Tong-Fei Fu, Jun-Song Wu, Bi-Chao Lu, Ping Zhang, He-Jing Liu
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      A new biflavonoid, (2″S)-8″-C-methyl-2″,3″-dihydrorobustaflavone-4′-methyl ether (1) and 5 known robustaflavones (2-6) were isolated from the 70% EtOH extract of Selaginella braunii for the first time. The structures of 1 and the known compounds were identified by performing a comprehensive analysis of spectroscopic data including ultraviolet-visible, high-resolution electrospray ionization mass spectrometry, 1-dimensional and 2-dimensional nuclear magnetic resonance, and circular dichroism spectra. Compounds 1-6 were determined for cytotoxic activity against 3 human cancer cell lines (SMMC-7721, MCF-7, and A549). Compound 1 exerted apparent antiproliferative effects on SMMC-7721, MCF-7, and A549 cells, with IC50 values of 18.6, 16.7, and 25.5 μM, respectively.
      Citation: Natural Product Communications
      PubDate: 2022-09-08T05:16:17Z
      DOI: 10.1177/1934578X221125056
      Issue No: Vol. 17, No. 9 (2022)
  • Active Compounds Screening and Hepatoprotective Mechanism of Shuganning
           Injection Based on Network Pharmacology and Experimental Validation

    • Authors: Qiyi Wang, Xiaotong Duan, Shan Li, Huaqing Lai, Weina Cheng, Jingwen Ao, Jianyong Zhang, Cancan Duan
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Objective: The study aimed to analyze the core active compounds and the potential mechanism of Shuganning injection (SGNI) through network pharmacology with biological experiments. Methods: Active compounds and targets of SGNI were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and Targetnet database, whereas the liver disease-related targets were identified through the Genecards and Online Mendelian Inheritance in Man databases. The “compound-target” and “protein-protein interaction” networks construction, core target identification, and pathway enrichment were then performed. Finally, the exploration of the mechanism of action for SGNI against acetaminophen (APAP)-induced liver injury in the HepaRG cells and validation of three identified protein targets was also carried out through western blot assay, including tumor protein p53 (p53, TP53), transcription factor Jun (Jun), and Caspase 3 (CASP3). Results: The result showed that a total of 312 active compounds of SGNI and 408 liver disease-related targets, as well as 131 core targets were revealed through databases, such as prostaglandin G/H synthase 1, prostaglandin G/H synthase 2, and nuclear factor NF-kappa B (NF-kB) p65 subunit (RELA). The core targets of SGNI were involved in regulating hepatitis B signaling pathway, NF-kB signaling pathway, Toll-like receptor signaling pathway, and tumor necrosis factor (TNF) signaling pathway. Moreover, results of molecular docking in this study indicated that chlorogenic acid, geniposide, baicalin, indirubin, and ganoderic acid A could act on RELA, JUN, TP53, TNF, CASP3, Caspase 8 (CASP8) and nuclear factor NF-kB p105 subunit (NFKB1). Similarly, results of western blot revealed that SGNI reduced the expression of p53, Jun, and Caspase 3 proteins in HepaRG cells as compared with the APAP group (P 
      Citation: Natural Product Communications
      PubDate: 2022-09-08T05:15:58Z
      DOI: 10.1177/1934578X221124756
      Issue No: Vol. 17, No. 9 (2022)
  • Berberine Promotes A549 Cell Apoptosis and Autophagy via miR-144

    • Authors: Zhiyan Gao, Chang Tan, Rula Sha
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Objective: To explore the effects of berberine on A549 lung cancer cells and corresponding changes in miR-144 expression, and the apoptosis and autophagy pathways. Methods: Cell proliferation was detected by cell counting Kit-8. The expression of miR-144 by quantitative PCR, caspase-3, caspase-3 cleaved, Bcl-2, Bax, beclin-1, LC3I, and LC3II were assessed using Western blot. Results: A549 proliferation was reduced with increasing berberine concentration. Berberine appeared to suppress A549 proliferation through apoptosis and autophagy, and, additionally, enhanced miR-144 expression. Berberine promoted A549 cell apoptosis by inhibiting caspase-3 cleavage and Bcl-2 expression and promoting Bax expression. Berberine also promoted A549 autophagy by raising the expression of beclin-1, LC3I, and LC3II. Conclusions: Berberine promotes A549 apoptosis and autophagy via miR-144.
      Citation: Natural Product Communications
      PubDate: 2022-09-07T07:21:06Z
      DOI: 10.1177/1934578X221124752
      Issue No: Vol. 17, No. 9 (2022)
  • Tanshinone IIA Inhibits Liver Fibrosis by Regulating COL1A1 Expression
           Through H19/let-7a in Mice

    • Authors: Chao Lin, Jianming Xing, Ziping Jiang, Liqun Sun, Yongjian Gao, Shuo Yang, Dongxu Wang, Ning Yin
      Abstract: Natural Product Communications, Volume 17, Issue 9, September 2022.
      Liver fibrosis is a serious health problem and may lead to advanced liver cirrhosis and hepatocellular carcinoma if left untreated. In this study, a mouse liver fibrosis model was established by the administration of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), and tanshinone IIA. Salvia miltiorrhiza Bunge extract, shown to play a regulatory role in liver fibrosis, was administered to study its effect on the expression of COL1A1. Mice were divided into 3 groups, control (Con), model (DDC), and drug administration (DDC-Tan) groups, and were subjected to the respective treatment for 2 months. Following treatment, the degree of liver fibrosis in mice in each group was determined. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and albumin levels in mice were determined using enzyme-linked immunosorbent assay (ELISA). Mouse liver tissues were used for hematoxylin-eosin and immunohistochemical staining. ELISA results showed that treatment with tanshinone IIA inhibited the expression of ALT, AST, and bilirubin in the DDC-Tan group compared with the DDC group. Hematoxylin-eosin, Sirius red, and α-SMA staining showed that liver injury was delayed in the DDC-Tan group. Immunohistochemistry, quantitative polymerase chain reaction, and Western blot results showed that COL1A1 expression was reduced after tanshinone IIA treatment. Moreover, the bioinformatic analysis indicated that let-7a targets COL1A1, and H19 regulates let-7a expression. The quantitative polymerase chain reaction and Western blot results confirmed that the H19/let-7a axis regulates COL1A1 expression. Thus, tanshinone IIA inhibited liver fibrosis by regulating COL1A1 expression through the H19/let-7a axis in mice.
      Citation: Natural Product Communications
      PubDate: 2022-09-05T06:22:22Z
      DOI: 10.1177/1934578X221123698
      Issue No: Vol. 17, No. 9 (2022)
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