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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
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European Journal of Medicinal Plants
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2231-0894
Published by SCIENCEDOMAIN international Homepage  [65 journals]
  • In vitro Antiproliferative Studies of Selected Medicinal Plants on
           Cancerous and Normal Cells

    • Authors: Regina W. Mbugua, Eliud M. Njagi, Chrispus M. Ngule, Peter G. Mwitari
      Pages: 1 - 10
      Abstract: Globally, approximately 13% of all deaths annually are attributed to cancer. Surgery, radiation and chemotherapy are the current treatment techniques for cancer; however, these methods are expensive, have high failure rates and have been associated with detrimental side effects. Plant derived products could be good candidates in alleviating challenges being experienced with these current methods. This study aimed at evaluating the phytochemistry, antiproliferation potential, and probable mechanism of action of Albizia gummifera, Rhamnus staddo and Senna didymobotrya plant extracts. The 3– (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium (MTT) assay dye was used in the determination of the antiproliferative activity of the extracts. Extracts induction potential of p53 (apoptosis) and VEGF (angiogenesis) genes’ expression was evaluated using Real Time PCR. Phytochemical screening was done as per standard procedures. Several plant extracts exhibited antiproliferative activity against the cancerous cell lines tested showing selective toxicity to cancer cells while sparing the normal cells (SI ≥ 3). An upregulation of p53 and down-regulation VEGF genes was observed. Phytochemical screening revealed presence of pharmacologically important phytochemicals in the plant’s extracts. The study findings suggest exploitation of these plant extracts as potential candidates for development of drugs for the management of breast and prostate cancer.
      PubDate: 2022-08-25
       
  • Phytochemical Screening and Antimicrobial Properties of Carissa edulis
           Extracts Obtained from Kaimosi Forest, Vihiga County, Kenya

    • Authors: George Timothy Opande
      Pages: 11 - 18
      Abstract: Medicinal plants still play an important role in human and animal healthcare. About 60% of the world’s population and 80% of Africa’s population depend on herbal medicine for their primary healthcare. In Vihiga county Kenya, C. edulis has been reported to manage several human disease conditions such as epilepsy, headache, toothache, cough, chest complaints, sickle cell anemia, gonorrhea, syphilis and rabies among others. Its therapeutic efficacy is attributed to numerous phytochemicals present in its extracts. In this study, a phytochemical analysis was carried out in the roots, leaves and bark extracts, antimicrobial effects on Escherichia coli and staphylococcus aureus laboratory cultures determined. The extracts were modified by grinding and ethanol used as solvent in the extraction. Different concentrations of 25%, 50%, 75% and 100% of plant extracts were used in the analysis and sterile distilled water used as the control. Data on zone growth inhibition was subjected to analysis of variance and the means were separated and compared using least significant differences at p≤ 0.05 by use of SAS statistical package. The results showed the presence of an array of phytochemicals in the leaves, bark and roots of the plant. The bark for example tested positive for tannins, saponins, flavanoids, terpenoids, glycosides and sterols while the leaves and roots tested negative for saponins and flavanoids respectively. The leaves exhibited the greatest inhibition against Escherichia coli with a mean diameter of 7.57mm and all the three parts exhibited a significant difference. The different concentrations also showed that inhibition increased with increase in concentration. The mean inhibition diameter at 100% was 8.96 while at 25% it was 7.21.
      PubDate: 2022-09-08
       
 
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