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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted by number of followers
Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 11)
Pharmazeutische Industrie     Full-text available via subscription   (Followers: 9)
Pharmaceutical Journal     Free   (Followers: 8)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Pharmaceutical Fronts     Open Access   (Followers: 7)
Molekul     Open Access   (Followers: 7)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 6)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 6)
AAPS Open     Open Access   (Followers: 5)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 4)
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 4)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
Canadian Journal of Pain     Open Access   (Followers: 3)
PharmaNutrition     Hybrid Journal   (Followers: 3)
Journal of Drug Delivery Science and Technology     Hybrid Journal   (Followers: 3)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Journal of Pharmacological Sciences     Open Access   (Followers: 3)
Indian Journal of Drugs in Dermatology     Open Access   (Followers: 2)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Current Research in Drug Discovery     Open Access   (Followers: 2)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Pharmacological Research - Modern Chinese Medicine     Open Access   (Followers: 2)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
International Journal of Immunopathology and Pharmacology     Open Access   (Followers: 2)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Journal of Pharmaceutical Sciences and Pharmacology     Full-text available via subscription   (Followers: 2)
Journal of Education and Science     Open Access   (Followers: 2)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 1)
Pediatric Pharmacology     Open Access   (Followers: 1)
Journal of Metabolomics & Systems Biology     Open Access   (Followers: 1)
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
Integrative Medicine International     Open Access   (Followers: 1)
Journal of Applied Pharmaceutical Research     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Farmakoèkonomika : Modern Pharmacoeconomic and Pharmacoepidemiology     Open Access   (Followers: 1)
Separation Science plus (SSC plus)     Hybrid Journal   (Followers: 1)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Journal of Biopharmaceutics Sciences     Open Access   (Followers: 1)
Expert Review of Precision Medicine and Drug Development     Hybrid Journal   (Followers: 1)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian     Open Access   (Followers: 1)
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 1)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
OpenNano     Open Access   (Followers: 1)
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Journal of Pharmaceutical Technology, Research and Management     Open Access   (Followers: 1)
Journal of the American College of Clinical Pharmacy : JACCP     Hybrid Journal   (Followers: 1)
Open Pharmacoeconomics & Health Economics Journal     Open Access   (Followers: 1)
Pharmactuel     Open Access   (Followers: 1)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Medicines     Open Access   (Followers: 1)
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Future Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Journal of Pharmaceutical Health Care and Sciences     Open Access   (Followers: 1)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
Pharmacy & Pharmacology     Open Access   (Followers: 1)
Clinical Complementary Medicine and Pharmacology     Open Access  
Exploratory Research in Clinical and Social Pharmacy     Open Access  
Indonesian Journal of Pharmaceutical Education     Open Access  
Future Drug Discovery     Open Access  
IUPHAR/BPS Guide to Pharmacology CITE     Open Access  
Journal of Applied Pharmaceutical Sciences and Research     Open Access  
Cephalalgia Reports     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacia     Open Access  
Research Results in Pharmacology     Open Access  
Journal of Toxins     Open Access  
Journal of Pharmaceutics & Pharmacology     Open Access  
Natural Product Communications     Open Access  
PharmaTutor     Open Access  
International Journal of Pharmaceutical Sciences and Developmental Research     Open Access  
Toxicological Research     Hybrid Journal  
Current Medical Science     Hybrid Journal  
EUREKA : Health Sciences     Open Access  
Iraqi Journal of Pharmacy     Open Access  
Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Medicine in Drug Discovery     Open Access  
Frontiers in Medical Technology     Open Access  
International Journal of Medical and Pharmaceutical Case Reports     Open Access  
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
Journal of Pharmaceutical Health Services Research     Hybrid Journal  
AboutOpen     Open Access  
Current Protocols in Pharmacology     Hybrid Journal  
Medical Cannabis and Cannabinoids     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Pharmaceutical Journal of Sri Lanka     Open Access  
Isan Journal of Pharmaceutical Sciences (IJPS)     Open Access  
Ciencia e Investigación     Open Access  
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community)     Open Access  
Toxicon : X     Open Access  
International Journal of Pharmaceutics: X     Open Access  
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia     Open Access  
Open Pharmacology Journal     Open Access  
ExRNA     Open Access  
International Journal of Pharmaceutics & Pharmacology     Open Access  
Antibody Therapeutics     Open Access  
Journal of Faculty of Pharmacy of Ankara University     Open Access  
Iraqi Journal of Pharmaceutical Sciences     Open Access  
Journal of Medicinal Botany     Open Access  
Journal of Medicinal Herbs and Ethnomedicine     Open Access  
International Journal of Pharmacokinetics     Hybrid Journal  
Neuropsychopharmacology Reports     Open Access  
Reviews on Clinical Pharmacology and Drug Therapy     Full-text available via subscription  
SynOpen     Open Access  
Matrix Science Pharma     Open Access  
Contract Pharma     Full-text available via subscription  
Journal of Cellular Neuroscience and Oxidative Stress     Open Access  
Istanbul Journal of Pharmacy     Open Access  
Acta Pharmaceutica Indonesia     Open Access  
Indonesian Journal of Pharmacy     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
High-Throughput     Open Access  
Scientia Pharmaceutica     Open Access  
Trends in Peptide and Protein Sciences     Open Access  
Acta Physiologica Hungarica     Full-text available via subscription  
Jurnal Farmasi Sains dan Praktis     Open Access  
Jurnal Kefarmasian Indonesia     Open Access  
Pharmaceutical Historian     Open Access  
Planta Medica International Open     Open Access  
Archives of Razi Institute     Open Access  
Journal of Pharmaceutical Research     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
FarmaJournal     Open Access  
Journal of Negative and No Positive Results     Open Access  
Pharmaciana     Open Access  
Folia Medica Indonesiana     Open Access  
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
International Journal of Pharmacology, Phytochemistry and Ethnomedicine     Open Access  
Фармацевтичний часопис     Open Access  
Ciência Equatorial     Open Access  
Iranian Journal of Pharmaceutical Research     Open Access  
Research & Reviews : A Journal of Drug Design & Discovery     Full-text available via subscription  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Research & Reviews : A Journal of Pharmacognosy     Full-text available via subscription  
Ars Pharmaceutica     Open Access  
Pharmacognosy Communications     Partially Free  
Egyptian Pharmaceutical Journal     Open Access  
Pharmacological Reports     Hybrid Journal  
PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Journal of Nanopharmaceutics and Drug Delivery     Full-text available via subscription  
Journal of Hydrogels     Full-text available via subscription  
Manufacturing Chemist     Full-text available via subscription  
Pharmaceutica Analytica Acta     Open Access  
Journal of Pharmacovigilance     Open Access  
Current Pharmacology Reports     Hybrid Journal  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
International Journal of Herbs and Pharmacological Research     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Research Journal of Pharmacognosy     Open Access  

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Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2406-9388 - ISSN (Online) 2580-8303
Published by Universitas Airlangga Homepage  [54 journals]
  • Isoprinosine along with Favipiravir or Oseltamivir in Patients with
           Moderate Covid-19 at RSD Dr. Soebandi Jember

    • Authors: Chrysnanda Maryska, Didik Hasmono, Sofiati Diah Baisuni, Ayunda Nur Hidayatiningsih, Arina Dery Puspitasari, Retna Dwi Puspitarini, Budi Suprapti
      Pages: 209 - 219
      Abstract: Background: Isoprinosine is an immunomodulator that is now being used to treat Covid-19 patients. Objectives: To evaluate Isoprinosine with Favipiravir or Oseltamivir in moderate Covid-19. Methods: In a retrospective observational analysis, in-hospital moderate Covid-19 patients treated between June 2020 and June 2021 were included. Results: Inclusion criteria for 364 patients were met, with 135 receiving Favipiravir-Isoprinosine (Group 1) and 229 receiving Oseltamivir-Isoprinosine (Group 2). In group 1, the majority of patients (58.50%) were female (35.60%), had no comorbidities (71.60%), were discharged with a positive PCR (74.80%), did not require a breathing apparatus (99.26%), had leukocyte levels between 4,5-11,0 (82.22%), lymphocyte levels between 25-33 (34.07%), and were discharged with no ground-glass opacity (34.07%) (54.10%), LOS was 9-13 days (50.37%), while the mortality rate was 0.70%. In group 2, the majority of patients were male (54.10%), with the highest age range being 42-56 years (35.80%), without comorbidities (69.0%), discharged with a positive PCR (72.50 %), and without the need for a breathing apparatus (99.13%), with leukocyte levels ranging from 4.5 – 11.0 (81.22 %), with lymphocyte levels ranging from 25.0 – 33.0 (26.20 %), and were discharged with no ground-glass opacity (49.34 %), LOS was 9 - 13 days (34.06 %), and the mortality rate was 0.87%.Conclusion: In this trial, it was determined that combining isoprinosine with antivirals favipiravir or Oseltamivir could produce significant clinical improvement.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.209-219
      Issue No: Vol. 9, No. 3 (2022)
  • The Effect of Decyl Glucoside on Stability and Irritability of
           Nanostructured Lipid Carriers-Green Tea Extract as Topical Preparations

    • Authors: Rufaidah Azzahrah, Noorma Rosita, Djoko Agus Purwanto, Widji Soeratri
      Pages: 220 - 228
      Abstract: Background: Green Tea Extract (GTE) is a natural antioxidant compound that can protect the skin from photocarcinogenesis (DNA damage due to ultraviolet exposure). GTE has low stability, which needs a delivery system such as Nanostructured Lipid Carriers (NLC) with decyl glucoside (DG) as a natural surfactant that at the right concentration can produce a significantly small particle size which can improve the stability of the NLC. Objective: To determine the effect of DG usage on the characteristics, physical stability, and irritability of NLC-GTE preparation. Methods: NLC-GTE preparation used the High Shear Homogenization (HSH) method with three formulas, which contained DG 2%, 2.5%, and 3% consecutively. Afterwards, the characteristic and physical stability tests were conducted using the thermal cycling method for three cycles with two different temperatures (48 hours/cycle, 2 - 8°C and 40°C). The irritability test used Hen's Egg Test on the Chorioallantoic Membrane (HET-CAM) method. Results: Characteristic test of organoleptic showed that all formulas were white, odorless, and had a semi-solid consistency. However, the pH, particle size, and polydispersity index values from all formulas were within the normal range of values. The physical stability test result showed that 3% DG was the most stable formula. This formula was within the non-irritating range of values in HET-CAM. Conclusion: NLC-GTE with an increased concentration of DG as a surfactant can improve the characteristics and physical stability of the preparation. F3 (3% DG) is the best formula compared to other formulas and indicates non-irritating in the HET-CAM test.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.220-228
      Issue No: Vol. 9, No. 3 (2022)
  • Effect of Alpha-Lipoic Acid on the Characteristics and Physical Stability
           of NLC-Green Tea Extract

    • Authors: Fairuz Yaumil Afra, Widji Soeratri, Djoko Agus Purwanto
      Pages: 229 - 234
      Abstract: Background: The addition of alpha-lipoic acid in Nanostructured Lipid Carrier-Green Tea Extract (NLC-GTE) has potential to increase effectiveness of anti-aging preparations. It happened because alpha-lipoic acid can increase stability and antioxidant activity. Objective: Comparing the physical characteristics and stability of NLC-GTE with or without alpha-lipoic acid. Methods: NLC-GTE manufactured using the High Shear Homogenization method. NLC-GTE was divided into two formulas, without the addition of alpha-lipoic acid for F1 and with the addition of alpha-lipoic acid for F2. The characteristics and physical stability were tested, including organoleptic, pH, particle size, and polydispersity index. Stability test was held using the thermal cycling method. Results: Based on characteristic test, it was found that F2 had larger particle size value than F1. The average particle size value of F1 is 313.9 ± 0.76 nm and 423.4 ± 0.75 nm for F2. The F1 and F2 preparations had a polydispersity index value below 0.3, so they were homogeneous. The average pH value of F1 is 5.998 ± 0.01, and F2 is 4.798 ± 0.004. The physical stability test showed a difference before and after the sixth day in particle size and pH, but it was still in the range, so it was safe. However, there was a separation in F1 after day 6. Conclusion: Based on the characteristics and physical stability tests, F1 (without alpha-lipoic acid) and F2 (with alpha-lipoic acid) had differences in particle size and pH. From the physical stability test, it can be concluded that F2 is more stable than F1.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.229-234
      Issue No: Vol. 9, No. 3 (2022)
  • Optimization Method and Stability Test to Determinate Luteolin, Quercetin,
           Apigenin, and Sinensetin Levels in Herbal Medicines Using TLC-Densitometry

    • Authors: Muhammad Hidayatullah, Mochammad Yuwono, Riesta Primaharinastiti
      Pages: 235 - 241
      Abstract: Background: Nephrolithiasis is a condition in which there are one or more kidney stones in the pelvis or calyces. Luteolin, quercetin, apigenin, and sinensetin are marker compounds in the extracts of Plantago major, Sonchus arvensis, Strobilanthes crispus and Orthosiphon stamineus which have nephrolithiasis activity. To control the quality of herbal medicines, a TLC-Densitometry method was developed in this study using luteolin, quercetin, apigenin, and sinensetin as phytochemical markers. Objective: The present work aimed to develop optimal conditions for analyzing luteolin, quercetin, apigenin, and sinensetin. Methods: Determination of optimal conditions for analysis is carried out by determining the composition of the mobile phase, chamber saturation time, and analysis wavelength. Silica gel 60 F254 was used as the stationary phase. Stability tests were carried out by analyzing standards and samples at 0, 4, 8, and 24 hours. Results: The best separation that produces symmetrical peaks of herbal medicine was achieved under isocratic conditions using the composition of the mobile phase chloroform : acetone: dichloromethane : acetonitrile : formic acid (6 : 2: 2 : 0,05 : 0.05 v/v/v/v/ v) with a wavelength of 335 nm with a saturation time of 30 minutes. Conclusion: In this study, the optimal conditions for the analysis of luteolin, quercetin, apigenin, and sinensetin. Luteolin, quercetin, apigenin, and sinensetin are unstable during 8 hours of storage. Therefore, standard solutions and samples must be made fresh to maintain stability.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.235-241
      Issue No: Vol. 9, No. 3 (2022)
  • The Effect of Insulin Administration on Medication Adherence in Type 2
           Diabetes Mellitus Patients with Neurological Complications

    • Authors: July, Rani Sauriasari, Nadia Farhanah Syafhan, Hadijah Tahir
      Pages: 242 - 251
      Abstract: Background: Medication adherence is essential to achieving controlled blood sugar in diabetic patients. Insulin generally provides better glycemic control but is considered painful and requires special techniques. Insulin administration in patients with neurological complications requires particular consideration because these complications can cause physical and cognitive barriers. Objective: This study analyses the effect of insulin administration on medication adherence in diabetic patients with neurological complications and the influence of various confounding variables (baseline characteristics, medical and medication history). Methods: This observational study was conducted with a cross-sectional design at a government hospital in East Jakarta from September 2021 to January 2022. The sample was type 2 diabetes mellitus patients with neurological complications who received antidiabetics for at least six months. The neurological complications include central nervous disorders (such as stroke) and peripheral nervous disorders (such as neuropathy). The independent variable was insulin administration, while the dependent variable was adherence, measured using subjective methods [Adherence to Refills and Medications Scale (ARMS)] and objective methods (Medication Refill Adherence (MRA) and HbA1c]. Results: Of 175 respondents, based on the three methods (MRA, ARMS, HbA1c), 13 respondents (7.4%) were adherent, namely one respondent (1.8%) in the insulin group and 12 respondents (10.1%) in the non-insulin group. Insulin administration affects adherence to antidiabetics by 0.123 times (95% CI: 0.015 - 1.024), or patients who use insulin have 87.7% lower adherence controlled by antidiabetic changes and the total number of medicines used. Conclusion: Insulin administration significantly affects medication adherence in diabetes mellitus patients with neurological complications.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.242-251
      Issue No: Vol. 9, No. 3 (2022)
  • The Influence of Feeling Lonely and Received Social Support on Medication
           Adherence in Elderly with Hypertension

    • Authors: Dwi Novita Sari, Wahyu Utami, Elida Zairina
      Pages: 252 - 261
      Abstract: Background: Hypertension is currently a non-contagious disease that primarily affects the elderly population in Indonesia. Medication adherence is critical in managing hypertension and reducing the risk of morbidity and mortality. Previous research has found that loneliness and support received by older adults with hypertension influence medication adherence. Objective: This study aimed to examine the impact of feeling lonely and receiving social support on medication adherence in the elderly with hypertension at the Community Health Center in Surabaya. Methods: The study design of this research was a descriptive cross-sectional study from December 2021 to March 2022. A total of 235 eligible subjects fulfilled the inclusion criteria. The instruments used in the data collection were the patient's information form, UCLA-Loneliness Scale, MOS-Social Support Survey, and the ARMS (Adherence to Refill and Medication Scale). Results: The results revealed that the correlation between loneliness and social support was significantly associated with medication adherence in the elderly with hypertension (p < 0.05). In addition, other factors, such as occupation status, living status, comorbidity, the number of drugs taken, and antihypertensive drug therapy, showed a significant correlation with medication adherence (p < 0,05). The most influential factor on medication adherence was loneliness (35.5%), followed by social support (24.4%), the number of drugs taken (7.1%), antihypertensive drug therapy (monotherapy or combination therapy (2.5%), occupation status (2.4%), comorbidity (1.6%), and living status (0.2%). Conclusion: This study confirms that feeling lonely and receiving social support affect medication adherence in the elderly with hypertension at the Community Health Center in Surabaya.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.252-261
      Issue No: Vol. 9, No. 3 (2022)
  • Sunscreen Cream Formulation of Noni Leaf Extract (Morinda citrifolia L.)
           with Emulsifier Combination of Tween 80 and Lecithin

    • Authors: Bianca Levie Tania, Rini Dwiastuti, Agatha Budi Susiana Lestari, Dewi Setyaningsih
      Pages: 262 - 271
      Abstract: Background: Noni leaf (Morinda citrifolia L.) extract is a natural product that can be used as a sunscreen. The extract contains flavonoids which function act as an antioxidant. In this work, sunscreen cream formulated with noni leaf extract was prepared using a combination of tween 80 and lecithin. Objective: The purpose of this study is to evaluate how the combination of tween 80 and lecithin affects the physical qualities of the cream, such as organoleptic, homogeneity, emulsion type, spreadability, adhesion, pH, and stability over 28 days of storage at room temperature, and to find the best formula. Methods: This study used 10% of noni leaf extract in the cream formulation. The Simplex Lattice Design (SLD) method was used to determine the effect of different concentrations of the two emulsifiers on the cream's spreadability, adhesion, and pH. Furthermore, the SLD was used to find the best formula. Results: The results showed that different concentrations of the emulsifier, which are the tween 80 and lecithin combination, affected the physical properties and storage stability of cream preparations. The interaction of tween 80 and lecithin is having a significant impact on the cream's adhesion and spreadability; however, the effect of the interaction on the pH value was not significant. Conclusion: The formula containing 2.5 % tween 80 and 2.5 percent lecithin was found to be the most effective in fulfilling the cream physical properties while remaining stable during storage.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.262-271
      Issue No: Vol. 9, No. 3 (2022)
  • Mannitol Production from Fructose by Using Resting Cells of Methylotrophic

    • Authors: Nisa Yulianti Suprahman, Khairul Basyar, Herman Suryadi
      Pages: 272 - 278
      Abstract: Background: Mannitol is a polyol sugar widely used in pharmaceutical and food industries which can be produced by bioconversion. Using of resting cells and methanol as a carbon source are strategies to increase the efficiency of mannitol production by increasing NAD(P)H needed in the reduction process. Objectives: This research aimed to optimize bioconversion condition by using resting cells of methylotrophic yeasts with methanol and fructose as carbon source and substrate, respectively. Methods: Several isolates were used including Candida sp, Debaryomyces nepalensis and Debaryomyces hansenii and three species suspected to be yeast isolated from a local paddy field. The methylotrophic characteristic of the yeasts was screened by turbidometry. The optimization of fermentation condition was conducted by varying cultivation time (24-96 hours), resting cell concentration (30-140 mg/mL), fructose concentration (7.5-15%), ammonium sulphate concentration (0.25-0.75%) and aeration condition (50-80%). Quantitative analysis of the mannitol was conducted by HPLC with NH2 column and Refractive Index Detector. Results: D. hansenii showed the highest yield value in mannitol production (23.17%), followed by D. nepalensis, Isolate A and Candida sp. (6.52%, 6.50% and 4.38%, respectively). Variation of bioconversion condition using D. hansenii showed that the highest resting cell concentration (140 mg/mL) incubated for 72 hours, moderate fructose concentration (10%), the highest ammonium sulphate concentration (0.75%) and moderate aeration condition (70%) would result in the highest yield value of mannitol (60%). Conclusion: This finding showed the potency of D. hansenii in mannitol production and gave preliminary information of its optimum fermentation condition.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.272-278
      Issue No: Vol. 9, No. 3 (2022)
  • Jelly Candy Hydroxyapatite from Mackerel Fish Bone

    • Authors: Lia Anggresani, Santi Perawati, Ryan Afandi, Rahmadevi
      Pages: 279 - 289
      Abstract: Background: Calcium is a mineral that is needed by bones and teeth. Calcium needs have not been achieved evenly among children, about 1000mg/day. Hydroxyapatite contains Ca and apatite which is good for the maintenance of bones and teeth. Hydroxyapatite is made from the bones of mackerel, where the bones of mackerel have a high source of calcium. For easy being consumed for children, the hydroxyapatite made in the form of jelly candy. Objective: The aim of this research was Hydroxyapatite Mackerel Fish Bone can be made as Jelly Candy. Methods: Hydroxyapatite from mackerel bones is made by the precipitation method. Then, hydroxyapatite was formulated into jelly candy with concentrations of hydroxyapatite was 18%, 19% and 20% respectively for Formula I, II and III. Jelly candy evaluation includes organoleptic test, gel strength, khamir and ALT ochre, weight uniformity, pH, hedonics, homogeneity and storage. Results: The evaluation showed that all jelly candy formulas are safe for consumption according to SNI 3547.2-2008. Conclusion: In conclusion, hydroxyapatite mackerel fish bone can be made as Jelly Candy with the best concentration in Formula 1.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.279-289
      Issue No: Vol. 9, No. 3 (2022)
  • Physicochemical Properties and Antioxidant Activity of Three Types of
           Monofloral Honey from Indonesia

    • Authors: Sulistyianingsih, Achmad Toto Poernomo, Riesta Primaharinastiti
      Pages: 290 - 297
      Abstract: Background: In addition to minerals, honey contains carbohydrates (glucose and fructose), protein, amino acids, water, enzymes, ash, vitamins, and other substances. Compounds of honey can affect the chemical properties of honey. Knowing the physicochemical properties of honey is very important because physicochemical properties affect the quality of honey. One of the biological activities of honey is an antioxidant. Antioxidants can interfere with oxidative processes, prevent disease, and play an important role in the body's defence system. Objective: to determine and compare physicochemical properties (color, viscosity, ash content, water content, reducing sugar (glucose), total phenolic compound, HMF) and antioxidant activities of monofloral honey samples from Indonesia. Methods: The color of honey are categorized using the Pfund scale. Viscosity measurement is carried out using a Brookfield viscometer. The water content is carried out using a refractometer. Phenolic content and antioxidant activities analysis were carried out by UV-VIS spectrophotometer. Results: The results show that rambutan honey from Malang has the highest physicochemical properties and antioxidant activity, which had an amber color, water content of 21.7% b/b, acidity 20.7 mL NaOH/Kg, viscosity of 33.08 poise, ash content of 0.17% b/b, reducing sugar 69.38%b/b, total phenolics content 533.7 mg GAE/Kg sample and IC50 0.111 µg/mL. Conclusion: The quality of honey varies from region to region. The best honey (according to SNI) is rambutan honey from Malang.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.290-297
      Issue No: Vol. 9, No. 3 (2022)
  • Assessing the Neurotoxicological Effect of the Acute Paraquat Aerosols
           Exposure in Causing Parkinsonism on Mouse through Behavioral Assays

    • Authors: Sherlo Maulana, Santi Nurul Kamilah, Choirul Muslim, Aceng Ruyani, R. R. Sri Astuti
      Pages: 298 - 304
      Abstract: Background: In the scientific community, there is no consensus that paraquat, a widely used herbicide, has a strong relationship with the occurrence of Parkinson’s disease. A reliable epidemiological explanation of how paraquat can induce parkinsonism is urgently needed because it relates to the agriculture community's potential public health problem. Objective: In this study, mice exposed to aerosols of paraquat solution were assessed by behavioral assays designed to observe whether mice exposed to paraquat aerosols develop cardinal symptoms of Parkinson’s disease, such as tremor-at-rest, bradykinesia, rigidity, and postural instability. Methods: To obtain the intended information, we carried out the observation on distal extremities, catalepsy test, wire suspension test, and swimming test consisting of the head position sub-test, the involvement of limbs sub-test, and the swimming direction test, respectively, to both the group of mice exposed to paraquat aerosols and the one which is not. Results: According to the result of the independent-samples t-test calculation on the data obtained from behavioral assays, a significant difference is shown only by the wire suspension test used to assess the development of forelimb rigidity and not the others. Conclusion: Therefore, this study showed that daily exposure for a week to paraquat aerosols insignificantly causes tremor-at-rest, bradykinesia, and postural instability in studied mice but dramatically affects their forelimb performance in the form of rigidity.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.298-304
      Issue No: Vol. 9, No. 3 (2022)
  • Viability and Antibacterial Activity of Bifidobacterium bifidum in
           Fermented Robusta Coffee for Diarrhea Treatment

    • Authors: Miksusanti, Elsa Fitria Apriani, Dimas Nur Hidayat
      Pages: 305 - 313
      Abstract: Background: Diarrhea can be treated with probiotic bacteria such as Bifidobacterium bifidum, which decreases the intestinal environment's pH to become acidic so that pathogenic bacteria cannot thrive. Objective: To make fermented coffee that can increase the number of probiotic bacteria Bifidobacterium bifidum and has antidiarrheal activity against pathogenic bacteria Escherichia coli. Methods: Robusta coffee (20.25% and 19.75%) was fermented using Saccharomyces cerevisiae, and then the probiotic bacteria Bifidobacterium bifidum was added. Unfermented coffee was compared with the same concentration (20.25% and 19.75%) to obtain four formulas. Organoleptic panelists tested all formulas to determine the best formula for fermented and non-fermented coffee. The number of Bifidobacterium bifidum and antibacterial activity was calculated on the optimum formulation using the Total Plate Count and Disc Diffusion Method. Result: The optimum formula obtained at fermented and unfermented coffee concentration was 20,25%. The number of probiotic bacteria Bifidobacterium bifidum growing in fermented and non-fermented coffee was 7.3 x 108 ± 32.4 and 3.1 x 108 ± 30.7 (p < 0.05). The diameter of the inhibition zone of the best fermented and non-fermented coffee was 11.5 ± 0.5 mm and 8.5 ± 0.5 mm, respectively (p < 0.05). Conclusion: Fermented coffee can increase the growth of the probiotic bacteria Bifidobacterium bifidum and has strong antibacterial activity against Escherichia coli bacteria.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.305-313
      Issue No: Vol. 9, No. 3 (2022)
  • Knowledge and Perception on Overclaim against the Behaviors of
           Implementing the COVID-19 Prevention Protocol Communities in Indonesia

    • Authors: Elsa Christina, Didik Setiawan, Dina Ratna Juwita, Lianawati
      Pages: 314 - 322
      Abstract: Background: COVID-19 occurs in various countries and has been declared a pandemic by WHO. Multiple efforts have been made to reduce the number of cases of COVID-19. However, the incidence of COVID–19 continues to increase, along with control efforts carried out by various parties, causing overclaims for the prevention or treatment of COVID–19. Objective This study aimed to determine the relationship between knowledge and public perception of the behavior of implementing the COVID-19 prevention protocol in Central Java Province. Methods: This cross-sectional study used primary data collected online via WhatsApp, Telegram, Instagram, and Facebook in December 2020. A total of 1,098 of 1,115 respondents passed the inclusion and exclusion criteria. Backward Elimination is used to determine factors related to behavior in the multivariable model stage using multiple logistic regression. Results: The knowledge, perception, and behaviors prevalence of implementing COVID-19 prevention protocols were good & enough 79.1% (95% CI 76.63 – 81.45), 96.6% (95% CI 95.38 – 97.55), and 92.3% (95% CI 90.62 – 93.78) respectively. The result revealed that Knowledge (adjOR = 2.034, 95% CI 1.253 - 3.302, P = 0.004) and Perception (adjOR = 4.064, 95% CI 1.859 - 8.882, P = < 0.001) were possibly associated with behaviors of implementing COVID-19 prevention protocols among communities in Central Java Province. Conclusion This study found a slight prevalence of good & enough knowledge, perception, and behaviors of implementing COVID-19 prevention protocols in a representative sample among Communities in Central Java Province. Knowledge and perceptions were statistically significant with behaviors.
      PubDate: 2022-12-09
      DOI: 10.20473/jfiki.v9i32022.314-322
      Issue No: Vol. 9, No. 3 (2022)
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