A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  

  First | 1 2 3        [Sort alphabetically]   [Restore default list]

  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted by number of followers
Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 11)
Pharmazeutische Industrie     Full-text available via subscription   (Followers: 9)
Pharmaceutical Journal     Free   (Followers: 8)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Pharmaceutical Fronts     Open Access   (Followers: 7)
Molekul     Open Access   (Followers: 7)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 6)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 6)
AAPS Open     Open Access   (Followers: 5)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 4)
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 4)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 3)
Canadian Journal of Pain     Open Access   (Followers: 3)
PharmaNutrition     Hybrid Journal   (Followers: 3)
Journal of Drug Delivery Science and Technology     Hybrid Journal   (Followers: 3)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Journal of Pharmacological Sciences     Open Access   (Followers: 3)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Current Research in Drug Discovery     Open Access   (Followers: 2)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Pharmacological Research - Modern Chinese Medicine     Open Access   (Followers: 2)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
Journal of Pharmaceutical Technology, Research and Management     Open Access   (Followers: 2)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Indian Journal of Drugs in Dermatology     Open Access   (Followers: 2)
International Journal of Immunopathology and Pharmacology     Open Access   (Followers: 2)
Journal of Pharmaceutical Sciences and Pharmacology     Full-text available via subscription   (Followers: 2)
Journal of Education and Science     Open Access   (Followers: 2)
Pediatric Pharmacology     Open Access   (Followers: 1)
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
Integrative Medicine International     Open Access   (Followers: 1)
Journal of Applied Pharmaceutical Research     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Pharmactuel     Open Access   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 1)
Journal of Biopharmaceutics Sciences     Open Access   (Followers: 1)
Separation Science plus (SSC plus)     Hybrid Journal   (Followers: 1)
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 1)
OpenNano     Open Access   (Followers: 1)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Journal of Metabolomics & Systems Biology     Open Access   (Followers: 1)
Farmakoèkonomika : Modern Pharmacoeconomic and Pharmacoepidemiology     Open Access   (Followers: 1)
Open Pharmacoeconomics & Health Economics Journal     Open Access   (Followers: 1)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 1)
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian     Open Access   (Followers: 1)
Journal of the American College of Clinical Pharmacy : JACCP     Hybrid Journal   (Followers: 1)
Expert Review of Precision Medicine and Drug Development     Hybrid Journal   (Followers: 1)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Medicines     Open Access   (Followers: 1)
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Future Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Journal of Pharmaceutical Health Care and Sciences     Open Access   (Followers: 1)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
Pharmacy & Pharmacology     Open Access   (Followers: 1)
Clinical Complementary Medicine and Pharmacology     Open Access  
Exploratory Research in Clinical and Social Pharmacy     Open Access  
Indonesian Journal of Pharmaceutical Education     Open Access  
Future Drug Discovery     Open Access  
IUPHAR/BPS Guide to Pharmacology CITE     Open Access  
Journal of Applied Pharmaceutical Sciences and Research     Open Access  
Cephalalgia Reports     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacia     Open Access  
Research Results in Pharmacology     Open Access  
Journal of Toxins     Open Access  
Journal of Pharmaceutics & Pharmacology     Open Access  
Natural Product Communications     Open Access  
PharmaTutor     Open Access  
International Journal of Pharmaceutical Sciences and Developmental Research     Open Access  
Toxicological Research     Hybrid Journal  
Current Medical Science     Hybrid Journal  
EUREKA : Health Sciences     Open Access  
Iraqi Journal of Pharmacy     Open Access  
Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Medicine in Drug Discovery     Open Access  
Frontiers in Medical Technology     Open Access  
International Journal of Medical and Pharmaceutical Case Reports     Open Access  
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
Journal of Pharmaceutical Health Services Research     Hybrid Journal  
AboutOpen     Open Access  
Current Protocols in Pharmacology     Hybrid Journal  
Medical Cannabis and Cannabinoids     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Pharmaceutical Journal of Sri Lanka     Open Access  
Isan Journal of Pharmaceutical Sciences (IJPS)     Open Access  
Ciencia e Investigación     Open Access  
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community)     Open Access  
Toxicon : X     Open Access  
International Journal of Pharmaceutics: X     Open Access  
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia     Open Access  
Open Pharmacology Journal     Open Access  
ExRNA     Open Access  
International Journal of Pharmaceutics & Pharmacology     Open Access  
Antibody Therapeutics     Open Access  
Journal of Faculty of Pharmacy of Ankara University     Open Access  
Iraqi Journal of Pharmaceutical Sciences     Open Access  
Journal of Medicinal Botany     Open Access  
Journal of Medicinal Herbs and Ethnomedicine     Open Access  
International Journal of Pharmacokinetics     Hybrid Journal  
Neuropsychopharmacology Reports     Open Access  
Reviews on Clinical Pharmacology and Drug Therapy     Full-text available via subscription  
SynOpen     Open Access  
Matrix Science Pharma     Open Access  
Contract Pharma     Full-text available via subscription  
Journal of Cellular Neuroscience and Oxidative Stress     Open Access  
Istanbul Journal of Pharmacy     Open Access  
Acta Pharmaceutica Indonesia     Open Access  
Indonesian Journal of Pharmacy     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
High-Throughput     Open Access  
Scientia Pharmaceutica     Open Access  
Trends in Peptide and Protein Sciences     Open Access  
Acta Physiologica Hungarica     Full-text available via subscription  
Jurnal Farmasi Sains dan Praktis     Open Access  
Jurnal Kefarmasian Indonesia     Open Access  
Pharmaceutical Historian     Open Access  
Planta Medica International Open     Open Access  
Archives of Razi Institute     Open Access  
Journal of Pharmaceutical Research     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
FarmaJournal     Open Access  
Journal of Negative and No Positive Results     Open Access  
Pharmaciana     Open Access  
Folia Medica Indonesiana     Open Access  
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
International Journal of Pharmacology, Phytochemistry and Ethnomedicine     Open Access  
Фармацевтичний часопис     Open Access  
Ciência Equatorial     Open Access  
Iranian Journal of Pharmaceutical Research     Open Access  
Research & Reviews : A Journal of Drug Design & Discovery     Full-text available via subscription  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Research & Reviews : A Journal of Pharmacognosy     Full-text available via subscription  
Ars Pharmaceutica     Open Access  
Pharmacognosy Communications     Partially Free  
Egyptian Pharmaceutical Journal     Open Access  
Pharmacological Reports     Hybrid Journal  
PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Journal of Nanopharmaceutics and Drug Delivery     Full-text available via subscription  
Journal of Hydrogels     Full-text available via subscription  
Manufacturing Chemist     Full-text available via subscription  
Pharmaceutica Analytica Acta     Open Access  
Journal of Pharmacovigilance     Open Access  
Current Pharmacology Reports     Hybrid Journal  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
International Journal of Herbs and Pharmacological Research     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Research Journal of Pharmacognosy     Open Access  

  First | 1 2 3        [Sort alphabetically]   [Restore default list]

Similar Journals
Journal Cover
Journal of Faculty of Pharmacy of Ankara University
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1015-3918 - ISSN (Online) 2564-6524
Published by Ankara University Homepage  [5 journals]
  • EXAMINATION OF THE AERIAL PARTS OF CLINOPODIUM PAMPHYLICUM SUBSP. DAVISII
           (CONTANDR. & QUÉZEL) GOVAERTS IN TERMS OF ANTIOXIDANT AND ENZYME
           INHIBITION POTENTIALS, TOGETHER WITH PHENOLIC PROFILE

    • Authors: Nuraniye ERUYGUR; Fatma AYAZ
      Abstract: Objective: The family Lamiaceae, consists of medicinal and aromatic plants, is represented by 46 genera and 571 species in Turkey. Traditional uses for Calamintha Miller species include utilizing as a spice, stimulant, antispasmodic, diaphoretic, expectorant, as well as treatment for stomach and throat aches. C. pamphylica subsp. davisii (Contandr. & Quézel) P.H. Davis is accepted as synonym of Clinopodium pamphylicum subsp. davisii (Contandr. & Quézel) Govaerts. C. pamphylicum subsp. davisii is an endemic species to Turkey. Until now, no biological and phytochemical research has been reported on this plant except for its essential oil research. Examining the antioxidant, and enzyme inhibition effects of C. pamphylicum subsp. davisii, as well as determining its phytochemical composition were the targets of the current study.Material and Method: To evaluate in vitro antioxidant potential (DPPH, ABTS, iron chelating, total phenol and flavonoid amounts) and enzyme inhibitory activities, such as acetylcholinesterase, butyrylcholinesterase, α-glucosidase, α-amylase and tyrosinase for C. pamphylicum subsp. davisii were measured with spectrophotometric methods. The quantities of different phenolic acids and flavonoids were measured using HPLC to analyze the phenolic composition of the plant extracts.Result and Discussion: Our results indicated that except for iron chelating methanol extract exhibited higher antioxidant properties over water extract using DPPH, and ABTS methods. In addition, methanol extract displayed more inhibition on the tested enzymes except for acetylcholinesterase, and α-glucosidase than water extract. As for HPLC findings, although chlorogenic acid was signified as the main phenolic compound for the methanol extract, caffeic acid was specified as the major phenolic for the water extract. These results provide a scientific basis for C. pamphylica subsp. davisii, which possessed the traditional uses in Turkish folk medicine.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • EVALUATION OF ZERUMBONE AS AN EGFR TYROSINE KINASE INHIBITOR BY MOLECULAR
           DOCKING METHOD

    • Authors: Dilek YONAR; Burcu BABA, Arzu KARAYEL
      Abstract: Objective: EGFR-TK domain is of great importance in the initiation and progression of various cancer types, especially lung cancer. The existing EGFR-TK inhibitors have numerous side effects, which make them improper to be utilized as cancer therapeutics. In this study, we aimed to analyze the activity of zerumbone as an anticancer agent targeting EGFR by molecular docking approach and to evaluate its activity in comparison with curcumin.Material and Method: MEP and HOMO-LUMO analyses were achieved at B3LYP/6-31G(D,P) level to evaluate electrostatic interactions that affect binding of EGFR with zerumbone and curcumin. Their binding energies were determined by molecular docking and compared with erlotinib as reference ligand.Result and Discussion: Docking studies showed higher bindings (lower binding energy) for curcumin and zerumbone with binding energies -8.0 and -7.6 kcal/mol, respectively, compared to erlotinib (-7.3 kcal/mol). However, there is no significant difference between them. The ΔE energy gap of zerumbone was 5.09 eV which implies that this compound has more stability in comparison with curcumin (ΔE=3.68 eV) and erlotinib (ΔE=4.29eV). Also, zerumbone showed strong hydrogen bond interactions with EGFR, making it candidate as EGFR inhibitor, as did both in curcumin and erlotinib. It was concluded that zerumbone may have potential for inhibitory activity against EGFR-TK.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • BENEFICIAL EFFECTS OF REBOXETINE ON IMPAIRED BEHAVIORAL PARAMETERS OF
           DIABETIC RATS

    • Authors: Nazlı TURAN YÜCEL; Ümmühan KANDEMİR, Umut İrfan ÜÇEL, Özgür Devrim CAN, Ümide DEMİR ÖZKAY
      Abstract: Objective: The incidence of emotional and cognitive disorders are higher in diabetic patients with respect to the general population. In this study, it was aimed to investigate the efficacy of reboxetine, a clinically prescribed drug for its antidepressant effect, on behavioral and cognitive alterations caused by diabetes in rats.Material and Method: An experimental diabetes model in rats was induced with a single 50 mg/kg injection of streptozotocin (i.v.). Reboxetine treatment was started 4 weeks after induction of diabetes in order to observe diabetic complications. Depression and anxiety levels of experimental animals were investigated by modified forced swimming and elevated plus-maze tests, respectively; cognitive performances were evaluated by Morris water-maze and passive avoidance experiments. The motor activities of the animals were also examined with the activity cage and Rota-rod tests.Result and Discussion: Obtained results indicated that the depression and anxiety levels of diabetic rats were increased and their cognitive performances were weakened. Reboxetine treatment (8 and 16 mg/kg) for two weeks reduced the elevated depression and anxiety levels in diabetic rats, while significantly improving their weakened cognitive performance. The findings indicated that reboxetine might possess a therapeutic potential for the cure of behavioral and cognitive impairements concomitant with diabetes.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • PROPOLIS EXTRACT COULD BE RECOMMENDED AS A NATURAL ANTIOXIDANT TO IMPROVE
           VEGETABLE OIL OXIDATIVE STABILITY

    • Authors: Ümit ERDOĞAN
      Abstract: Objective: In this study, the total phenolic content, individual phenolic components, and total antioxidant capacity of the ultrasonically assisted ethanolic extract of propolis were investigated in detail. Another aim of our study was to reveal the effects of propolis extracts on olive oil lipid oxidation compared to synthetic antioxidants (BHA, BHT) with tests performed under accelerated thermal conditions.Material and Method: We determined the total antioxidant capacity of propolis extract by CUPRAC assay. On the other hand, the polyphenolic content of propolis extract was determined by the Folin assay. Identification of phenolic compounds of propolis was performed using reversed phase high performance liquid chromatography (RP-HPLC). The effect of propolis on the oxidative stability of extra virgin olive oil under accelerated storage conditions was studied using the Shall oven test.Result and Discussion: The results revealed that propolis is rich in phenolic components. According to the CUPRAC assay, the total antioxidant capacity of propolis extract was calculated to be 2.013 ± 0.03 mmol TR/g-propolis extract. The total phenolic content of the propolis extract was calculated to be 1.67 ± 0.008 mmol TR/ g-propolis extract. The oils with propolis extract incorporated exhibited much better chemical stability, including lower peroxide value and partly decreased tocopherols content. Data showed that propolis extract was more effective in delaying the oxidation of olive oil compared to synthetic antioxidants such as BHA and BHT.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • INTEGRATIVE AND BIOCHEMICAL PARAMETERS IN RATS IN THE SIMULATION OF
           DOXORUBICIN CHRONIC HEART FAILURE AND DURING THE USE OF Β-ADRENERGIC
           BLOCKERS

    • Authors: Igor BELENİCHEV; Pavlo BAK, Olena POPAZOVA, Victor RYZHENKO, Nina BUKHTİYAROVA, Andrii PUZYRENKO
      Abstract: Objective: In the treatment of chronic heart failure, β-blockers are actively used - Carvedilol, Nebivolol, Metoprolol, Bisoprolol, etc. However, they have a number of serious adverse reactions, and their therapeutic efficacy does not always meet the needs of the clinic. All this prompted the creation of a new potential drug Hypertril (bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazolium. We aimed to conduct a comparative assessment of β-blockers of different generations and "Hypertril" in the conditions of modeling the doxorubicin model of chronic heart failure (CHF) in terms of the effect on biochemical markers of myocardial damage and integrative parameters.Material and Method: CHF was modeled on 85 white outbred rats weighing 190–220 g by administering doxorubicin at a total dose of 15 mg/kg, nebivolol (10 mg/kg), carvedilol (50 mg/kg), bisoprolol (10 mg/kg), metoprolol (15 mg/kg) and hypertril (3.5 mg/kg) were administered intragastrically once a day as a suspension 1% starchy mucus for 30 days after 14 days of doxorubicin administration. The cardioprotective effect of drugs was assessed by improving integrative parameters (survival, heart mass index, severity in points) and by normalizing cardiospecific markers (NT-proBNP, D-dimer, eNOS, MB-CPK, and ST2).Result and Discussion: The introduction of Hypertril not only prolonged the life of animals with CHF in comparison with the reference drugs, but also prevented early death and contributed to a decrease in the severity of symptoms (hydrothorax, ascites, scrotal edema). The administration of hypertril to rats with CHF led to a decrease in mortality, a decrease in the heart mass index, in the blood of the main cardiospecific markers to the values of intact animals, and also led to an increase in expression of eNOS, which testified to its significant cardioprotective effect with NO-mimetic effect. The obtained results demonstrated the undoubted advantage of Hypertril over the basic β-adrenergic blockers and experimentally substantiated further in-depth studies to create a drug based on it for the treatment of CHF.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • COMPARISON OF ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS OF SOME
           POLYPHENOLIC COMPOUNDS AND THEIR BIOTRANSFORMATION EXTRACTS

    • Authors: Damla KIRCI; Betül DEMİRCİ
      Abstract: Objective: Microbial transformations are green biotechnological processes where different microorganisms or enzymes are used to produce new metabolites from defined substrates. Hesperidin, quercetin, and their derivatives have been proven in scientific research to have a variety of biological activities, such as antioxidant, antimicrobial, and anticancer activities.Material and Method: This study performed the microbial transformation of hesperidin and quercetin utilizing 13 different microbial strains. The transformation extracts of hesperidin and quercetin were investigated in antioxidant (DPPH· and ABTS·+ methods) and anti-inflammatory effects.Result and Discussion: The biotransformation of hesperidin was observed in 5 of 13 strains. There were Rhizopus stolonifera, Saccharomyces pararoseus, S. cerevisiae, Penicillium claviforme, and Fusarium solani while microbial transformation of quercetin was identified Aspergillus flavus and Penicillium claviforme. The results of this research show that the extracts obtained with the Aspergillus and Penicillium strains were more effective in terms of antioxidant and anti-inflammatory effects. DPPH· antioxidant activity of A. flavus extract (IC50: 22.55±0.32 µg/ml) was higher than the other biotransformation extracts. The IC50 value of R. stolonifer from the hesperidin transformation extracts is 25.93±0.36 µg/ml. The microbial transformation of hesperidin by Penicillium strain has not been researched previously. 
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • CHEMICAL COMPOSITION AND IN VITRO ANALYSIS OF ANTIBACTERIAL ACTIVITY OF
           ACUTODESMUS DIMORPHUS (TURPIN) P.M. TSARENKO (SCENEDESMACEAE, CHLOROPHYTA)
           

    • Authors: Eldrin ARGUELLES
      Abstract: Objective: Green microalgae are fast growing organisms and are known to have diverse bioactive compounds and biomolecules. The chemical composition and antibacterial activities of a green microalga, Acutodesmus dimorphus BIOTECH 4039 were studied.Material and Method: Dried algal biomass of A. dimorphus was subjected to proximate and elemental composition analysis. Methanolic extract of A. dimorphus was used to determine the total phenolic content (TPC) and antibacterial activity of the microalga. TPC was measured using the Folin–Ciocalteu method. On the other hand, the antibacterial activity against medically important bacterial pathogens (Staphylococcus epidermidis BIOTECH 10098, penicillin acylase-producing Bacillus cereus BIOTECH 1509, Listeria monocytogenes BIOTECH 1958, Methicillin-Resistant Staphylococcus aureus BIOTECH 10378, Pseudomonas aeruginosa BIOTECH 1824, penicillin acylase-producing Escherichia coli BIOTECH 1634, and Serratia marcescens BIOTECH 1748) was done using modified Kirby-Bauer diffusion method.Result and Discussion: A. dimorphus contained high amounts of protein, ash, and lipid with percent composition of 43.19 ± 0.13, 26.92 ± 0.01, and 14.17 ± 0.04, respectively. The elemental nutrient composition of the algal biomass was observed to be in a decreasing order of Ca > Mg > K > Mn > Na > Fe > Zn > Pb > Cu > Cd >Cr. In addition, A. dimorphus has a TPC of 5.34 ± 0.09 mg GAE/g. Potent antibacterial activities of A. dimorphus extract were observed against Methicillin-Resistant Staphylococcus aureus, S. epidermidis, penicillin acylase-producing Bacillus cereus with zones of inhibition of 15.1 ± 0.3 mm, 13.5 ± 0.1 mm, and 6.82 ± 0.7 mm, respectively. The study shows the use of A. dimorphus as good alternative source of important compounds and microelements that can be use in industrial and pharmaceutical application
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • DEVELOPMENT OF BESIFLOXACIN HCL LOADED OCULAR IN SITU GELS; IN VITRO
           CHARACTERIZATION STUDY

    • Authors: Heybet Kerem POLAT; Sedat ÜNAL
      Abstract: Objective: The aim of this study is to develop in situ gel formulations containing besifloxacin hydrochloride are heat triggered, which are prepared by using different poloxamer and derivatives different polymers that will change the gelling temperature to increase corneal contact time, regulate drug release, improve ocular bioavailability and increase patient compliance increase mucoadhesion.Material and Method: Various concentrations of poloxamer 188 (P188) and poloxamer 407 (P407) were used to create the in situ forming gels. To increase the gel's capacity for bioadhesion, mucoadhesives such hydroxypropylmethyl cellulose (HPMC) or hydroxyethyl cellulose (HEC) were included in the formulations. Drug release in vitro, sol-gel transition temperature, rheological behavior, pH, clarity, and mucoadhesion force were all assessed for the produced formulations.Result and Discussion: The developed formulations' gelation temperatures ranged from 29 to 35°C. The preparations' viscosity and mucoadhesion force increased with increasing P407, HPMC, and HEC concentrations. Besifloxacin HCl forms in situ gel formulas with K1, K2, K3, and K6 suited for mucoadhesion characteristics, gelation temperature, and viscosity. These formulations exhibit pseudoplastic flow. Increasing polymer concentrations resulted in a reduction in the burst release of the formulations. However, at the end of 6 hours, drug release was finished in all formulations. The results show that in situ gels containing P407 and P188 show promise for besifloxacin HCl application.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • MORPHOLOGICAL AND MICROMOPHOLOGICAL INVESTIGATION OF MARRUBIUM L.
           (LAMIACEAE) TAXONS DISTRIBUTED IN THE AEGEAN REGION

    • Authors: Tuğçe DEMİRÖZ AKBULUT; Şüra BAYKAN
      Abstract: Objective: In this study was aimed to compare 9 Marrubium L. taxa, 4 of which are endemic, and different populations of the same taxon in terms of micromophological and morphological characters, distributed in the Aegean Region. In addition, it was aimed to evaluate whether the populations of M. vulgare, which is included in the composition of many drugs abroad, and which spread in our country, comply with the criteria of the European Pharmacopoeia.Material and Method: In the morphological examinations, macroscopic structures were examined and calyx structures were visualized by considering the important structures in identification key in the Flora of Turkey and the European Pharmacopoeia criteria. Micromophological examinations were based on the European Pharmacopoeia criterias.Result and Discussion: Different types of non-glandular and glandular hairs and micromophological structures such as stoma, vascular bundle and collenchyma were found in all taxa. Two subspecies of Marrubium parviflorum and endemic taxa M. rotundifolium, M. globosum subsp. globosum and M. bourgaei subsp. caricum according to the identifiaction key in Flora of Turkey, there are confusions in terms of diagnosis and taxonomies. In addition, 8 samples of M. vulgare population collected from 9 different localities were found to be suitable for the European Pharmacopoeia.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • THE COMPARISON OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF NOVEL
           PYRIMIDO[1,2-a]PYRIMIDINE COMPOUNDS

    • Authors: Duygu BAYRAMOĞLU; Merve DEMİRBÜGEN ÖZ, Merve Eylül KIYMACI
      Abstract: Objective: Heterocycles with a pyrimidopyrimidine scaffold have been the focus of interest of researchers in the field of medicinal chemistry as they have a wide range of biological properties. In the current study antioxidant capacity and antibacterial activity of a series of new pyrimido[1,2-a]pyrimidines were investigatedMaterial and Method: All these novel compounds were screened for their in vitro antioxidant effectiveness using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging test and the antibacterial activity was determined using the broth microdilution method according to The European Committee on Antimicrobial Susceptibility Testing standards (EUCAST) as a minimal inhibition concentration (MIK) against some Gram- positive and negative ATCC strains.Result and Discussion: The overall range of DPPH free radical scavenging activity was found to be 3.86-6.90% at 0.1mM and 6.28–16.59% at 1mM for the novel pyrimidopyrimidine derivates. Since the free radical scavenging activities of all the compounds were below 20%, it was considered that the weak activity of compounds might be due to the absence of an enolizable amide group in the pyrimidine ring. In addition to that, some of the selected compounds showed weak antioxidant activity. MIC values of all compounds were found as > 100 µg/ml against Staphylococcus aureus ATCC 29213, methicillin resistant Staphylococcus aureus ATCC 43300, Enterococcus faecalis 29212, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, Pseudomonas aeruginosa ATCC 27853. The data obtained from present study require the synthesis of derivatives with various substituents in different positions of the pyrimidine ring in order to be able to evaluate and interpret more comprehensively in future studies.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • DEVELOPMENT OF NANOPARTICLE BASED SENSITIVE SPECTROPHOTOMETRIC METHOD FOR
           THE DETERMINATION OF CIPROFLOXACIN

    • Authors: Hakan BALCI; Zehra Özden ERDOĞAN, Alperen ÖZDEMİR
      Abstract: Objective: Ciprofloxacin is a fluoroquinolone antibiotic used in the fight against many bacterial infections. The aim of this study is to develop a rapid and sensitive method for the spectrophotometric determination of metal nanoparticle-based ciprofloxacin.Material and Method: AgNP was used as metal nanoparticle to develop the method. The localized surface plasmon resonance (LSPR) absorption band of AgNP at 395.5 nm was used for the spectrophotometric determination of ciprofloxacin. In order to determine the optimum pH value of the phosphate buffer solution used in the experimental studies, the changes in the absorbance value of ciprofloxacin-AgNP at different pH values were examined. Changes in AgNP size were detected by DLS measurements.Result and Discussion: In our study, a new spectrophotometric method based on AgNP was developed for the determination of ciprofloxacin in pharmaceutical preparations. The linear working range for the developed method was determined as 0.003-3.313 mg/L in pH 6.0 phosphate buffer and 0.025-2.50 mg/L in pH 8.0 phosphate buffer. In the recovery study performed to determine the amount of ciprofloxacin in the ophthalmic solution, the recovery value was found to be 87±3.3%. In the light of these data, it is thought that the AgNP-based method developed for the determination of ciprofloxacin can be used as an effective analysis method in clinical analysis.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • EVALUATION OF THE POTENTIAL ANTIBACTERIAL ACTIVITY OF BERBERIS CRATAEGINA
           DC.: WITH FOCUS ON QUORUM SENSING INHIBITION OF CHROMOBACTERIUM VIOLACEUM
           ATCC 12472

    • Authors: Fatma Tuğçe GÜRAĞAÇ DERELİ; Evren ARIN, Ebru ÖNEM
      Abstract: Objective: In the present study described here, we set out to look into the quorum sensing inhibitory activity of the methanolic seed extract of Berberis crataegina DC. through quorum sensing -controlled inhibition of violacein pigment production in Chromobacterium violaceum ATCC 12472. In addition, the antibacterial activity of the extract on various Gram-negative and Gram-positive standard strains was evaluated. Also phenolic contents in the extract were detected by using HPLC analysis.Material and Method: “The phytochemical profile of the seed extract was performed by High-Performance Liquid Chromatography technique. Antibacterial activity assays were performed on the extract using the agar well method and inhibition of the violacein pigment production was investigated spectrophotometrically.Result and Discussion: According to antibacterial activity results Gram negative bacteria were more resistant than Gram positive bacteria and violacein pigment production was inhibited by 66% percentage. Phytochemical analysis results also showed that the major component in the extract is chlorogenic acid, with a value of 1974.91 µg/mL.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • GENETIC DIVERSITY OF ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM
           DIFFERENT HOSPITALS

    • Authors: Hilal Basak EROL; Banu KAŞKATEPE, Nurten ALTANLAR, Sulhiye YILDIZ, Süleyman YALÇIN
      Abstract: Objective: The genotypic analysis of the strains can provide information to evaluate the genetic relationships among strains and epidemiological investigations, and it is crucial for monitoring their circulation in different geographic regions. This study was to aim to identify genetic similarities or dissimilarities among clinical Acinetobacter baumannii (A. baumannii) isolates from four different hospitals.Material and Method: In this study, 78 non-duplicate clinical isolates of A. baumannii were received from patients in the critical care units. The colistin MIC values of 24 A. baumannii strains randomly selected from four different hospitals and known to have antibiotic susceptibility were determined. These strains were genetically characterized by the Enterobacterial repetitive intergenic consensus (ERIC)-PCR method.Result and Discussion: The results of the study showed that the isolates were divided into 2 clusters (A1 and A2) and Cluster A2 was represented by a single genotype (C1) and 23 interrelated genotypes were in Cluster A1.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • INVESTIGATION OF THE ANTIBIOTIC RESISTANCE PROFILE OF KLEBSIELLA
           PNEUMONIAE ISOLATES ISOLATED FROM DIFFERENT CLINICAL SPECIMENS: ONE-YEAR
           DATA DURING THE COVID-19 PANDEMIC PROCESS

    • Authors: Derya DOĞANAY; Müzeyyen AYDIN, İbrahim Serkan AVŞAR
      Abstract: Objective: In recent years, the rapid spread of resistance caused by the production of extended-spectrum beta-lactamase (ESBL) among bacteria has increased the importance of K. pneumoniae bacteria. Regular monitoring of antibiotic resistance rates of bacteria is very important for the treatment of infections and new treatment methods that can be developed. In the study, it was aimed to determine the antibiotic resistance profiles and ESBL positivity rates of K. pneumoniae isolated from patients who applied to Biruni University Hospital between March 2020 and March 2021, covering the COVID-19 Pandemic.Material and Method: In the study, antibiogram test results and ESBL presences of K. pneumoniae bacteria isolated from samples sent from different outpatient clinics and services were evaluated retrospectively. GraphPad InStat V. 3.05 was used for statistical analysis.Result and Discussion: In the study, 423 K. pneumoniae bacteria were isolated from different clinical samples. Of the isolates, 161 (38%) were obtained from the endotracheal aspirate (ETA) sample, and 349 (82.5%) were obtained from the intensive care clinic. In addition, 358 (84.63%) of the isolates were ESBL positive and 65 (15.36%) ESBL negative. It was observed that the majority of the isolates obtained were resistant to ampicillin, and almost all of the ESBL positive isolates were resistant to ceftazidime. Both the studies and the results of the study show that the number of K. pneumoniae strains showing multiple antibiotic resistance has increased over time and this increase continues exponentially.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • DESIGN AND SYNTHESIS OF SOME ARYLHYDRAZONE DERIVATIVES AS POTENTIAL FAAH
           INHIBITORS

    • Authors: Zehra Tuğçe GÜR MAZ; Sümeyye TURANLI, H. Burak CALISKAN
      Abstract: Objective: The aim was to design, synthesis and investigation of possible interactions in the enzyme active site of a series of arylhydrazone derivatives for the inhibition of the FAAH enzyme.”Material and Method: Arylhydrazone derivatives were obtained through the reaction of nicotinic hydrazide or benzohydrazide with appropriate aldehyde derivatives, and the obtained crude product was recrystallized from ethanol. After elucidating chemical structures of the compounds via spectroscopic methods, the inhibitory activities against hFAAH were screened. The results were further supported with molecular modeling studies.Result and Discussion: In this study, a new series of seven arylhydrazone derivatives were screened against hFAAH. 4-phenoxyphenyl bearing derivative 5 was found to inhibit hFAAH 40 % at 10 µM which indicates that newly developed inhibitor could serve as a starting point for improving inhibitory effect of the new series.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • INVESTIGATION OF THE SYNERGISTIC EFFECT ON THE HOSPITAL INFECTION AGENT
           PSEUDOMONAS AERUGINOSA OF ANTIVIRAL DRUGS

    • Authors: Şükran ÖZTÜRK
      Abstract: Objective: It was aimed to investigate the synergistic efficacy of antiviral drugs and antibiotics in combination for the treatment of Pseudomonas aeruginosa (P. aeruginosa), which is a common nosocomial infection agent.Material and Method: Umifenovir (UMF) and Ribavirin (RBV) antibiotics as active ingredients of antiviral drugs, colistin and beta-lactamase inhibitor sulbactam were studied. Multi-Drug Resistant (MDR) and Colistin (COL) resistant P. aeruginosa clinical isolates were included in the study. On Pseudomonas aeruginosa, the minimal inhibition concentration of UMF, RBV, KOL and SUL separately with the microdilution method, and the synergistic activity of UMF -RBV and KOL- Sulbactam (SUL) were examined with the checkerboard synergy test.Result and Discussion: In resistant strains, synergy and partial synergy occurred in combinations of RBV with COL and SUL (FIC = 0.375-0.75), whereas in the study conducted with ATCC 27853 strain, inferential and additive (FIC = 1.0-2.0) interactions were observed to be more intense. While synergy and partial synergies (FIC=0.53-0.75) were noted in combinations of UMF with KOL and SUL, an additive effect (FIC=1.0) was detected in ATCC 27853 strains. When the results were evaluated, it was seen that the use of UMF and RBV in combination with KOL and SUL was more effective on resistant strains, and the idea that the combinations could be used as an alternative option in the treatment of resistant nosocomial infections should be supported by future studies.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • MONOCLONAL ANTIBODIES USED IN CANCER DIAGNOSIS AND TREATMENT

    • Authors: Merve BABAÇ; Meliha EKİNCİ, Derya İLEM-ÖZDEMİR
      Abstract: Objective: Cancer is a disease that develops with the uncontrolled proliferation of cells in the body and is characterized by abnormal and uncontrolled growth of cells. While the incidence of cancer is increasing day by day, new approaches in the diagnosis and treatment of cancer are gaining great importance. Anatomical imaging techniques and nuclear imaging systems are frequently used for cancer diagnosis. In the treatment of cancer, in addition to traditional approaches (surgery, radiotherapy, chemotherapy), targeted approaches have been used recently. Targeted approaches in cancer treatment mostly include small molecule tyrosine kinase inhibitors and monoclonal antibodies. Monoclonal antibodies were initially obtained from hybridomas formed by B cells and myeloma cancer cells of antigen-immunized mice. It is mostly used in the diagnosis, purification and analysis of biological materials, diagnosis and treatment of cancer, and prevention of tissue rejection in organ transplants. Monoclonal antibodies have great advantages because they take less time to develop and cost less. In addition to these advantages, although different side effects have been detected in the direction of research, monoclonal antibodies are in great demand today due to their target specificity and other advantages.Result and Discussion: Although research on monoclonal antibodies and cancer diagnosis and treatment continue today, this subject continues to be an important and curious subject in terms of medical science. In this review, monoclonal antibodies, which are frequently used in cancer diagnosis and treatment, and their targets, mechanisms of action and clinical uses will be discussed.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • EVALUATION OF ROUNDUP® TOXICITY IN HUMAN LUNG CELLS

    • Authors: Burcu ÜNLÜ ENDİRLİK; Elçin BAKIR, Aysun ÖKÇESİZ, Zuhal HAMURCU, Ayşe EKEN, Aylin GÜRBAY
      Abstract: Objective: In this study, toxic effects of Roundup, one of the most common glyphosate-based herbicides (GBHs), were assessed on human bronchial epithelial cells (BEAS-2B).Material and Method: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and neutral red uptake assays were implemented for evaluation of cell viability at 24 and 48 h. Apoptosis detection was made by Muse analyzer while Hoechst staining was employed to detect apoptotic nuclear changes. In addition, dichlorofluorescein diacetate assay was used for the assessment of reactive oxygen species (ROS) formation.Result and Discussion: Similar half maximal inhibitory concentrations were obtained from cytotoxicity assays. Results showed that significant reduction in the viability of BEAS-2B cells started to occur from 200 µM at 24 h and 50 µM at 48 h treatment times. Roundup treatments were found to cause apoptosis in a dose-dependent manner in both time points and apoptosis increased with increasing exposure time. Moreover, it was observed that cellular ROS formation was induced following Roundup exposure. These findings suggest that GBHs can stimulate ROS production, as well as apoptosis on healthy human lung cells which is important considering inhalation is one of the primary exposure routes to this group of chemicals.  
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • THE EFFECTS OF MELATONIN, FLUOXETINE AND THEIR COMBINATIONS ON STRESS
           INDUCED BEHAVIORAL AND COGNITIVE IMPAIRMENTS IN MICE

    • Authors: Merve İNCİ ÇAMÇİ; Meral ERDİNÇ, İlker KELLE, Emre UYAR, Levent ERDİNÇ
      Abstract: Objective: Melatonin (Mel) is a hormone with anti-depressant and anti-oxidant features. It is well known that melatonin protects brain cells from reactive oxygen species and that the brain's high oxygen consumption and lipid content make it particularly vulnerable to oxidative stress caused by prolonged stress. This study aims to investigate the effects of melatonin, fluoxetine and their combinations on emotional memory, depression, and anxiety-like behavioral changes induced by immobilization (Imb) stress.Material and Method: 48 male Balb/c mice were divided into eight groups: Cnt (control), Imb, Imb+Mlt, Imb+Flx (fluoxetine), Imb+Mlt+Flx, Mlt, Flx and Mlt+Flx. For seven days in a row, the mice underwent daily immobilization stress for 6 hours. Mice were treated with Mlt (10 mg/kg) and Flx (20 mg/kg). All animals were subjected to the behavioral tests; forced swimming test (FST), open field test (OFT), elevated plus maze (EPM), passive avoidance test (PAT) and hot plate (HP) test. After all behavioral tests, brain tissues were obtained for malondialdehyde level analysis.Result and Discussion: OFT test data showed the time spent in the central zone and the number of entrances to the central area were significantly lower in the Imb group compared to the Cnt group, these were higher in the Imb+Flx, Imb+Mlt, Imb+Mlt+Flx groups compared to the Imb group. Also, according to the data obtained from FST, immobile time was significantly higher in the Imb group compared to the Cnt group, it was lower in the Imb+Flx, Imb+Mlt, Imb+Mlt+Flx groups compared to the Imb group. Besides, it was demonstrated that the emotional memory index was statistically higher in the Imb group compared to the Cnt group, and the increasing of memory index returned to normal in the Imb+Mlt and Imb+Mlt+Flx groups with PAT. And also, lipid peroxidation level, which increased in the Imb group, decreased significantly in the Imb+Flx, Imb+Mlt, and Imb+Mlt+Flx groups. As a result, it was observed that melatonin has anti-depressant, anxiolytic, antioxidant effects and normalized emotional memory. Also, melatonin, fluoxetine and their combinations exert similar effects in the present study.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • FORMULATION AND EVALUATION OF PARENTERAL IN-SITU FORMING BIODEGRADABLE
           IMPLANT FOR CONTROLLED RELEASE OF LEVOTHYROXINE SODIUM

    • Authors: Manish GOYANİ; Meghraj SURYAWANSHİ, Ridhdhesh JIVAWALA
      Abstract: Objective: The objective of present research work is formulation and evaluation of parenteral in-situ forming biodegradable implant for controlled release of levothyroxine sodium.Material and Method: The present study used N-Methyl pyrrolidone (NMP) and triacetin as solvents and PLGA as a biodegradable polymer to manufacture two biodegradable polymeric drug delivery systems, in-situ forming implant (ISFI) and in-situ micro particles (ISM). Other evaluation tests, such as sterility, percent drug entrapment capacity, and so on, were also carried out. ISFI and ISM were tested for up to one month at three different temperatures (4ºC, 25ºC, and 40ºC).Result and Discussions: The drug release from both systems was compared. In batch F4, burst release was 10.72%, while in batch EP8, it was 8.16%. F4 was released 94.54% in roughly 30 days and EP8 was released 95.72%. The polymer content, type of solvent (hydrophilic or hydrophobic), and implant morphology all contributed to increased burst release in the ISFI formulation. Burst release was decreased using a combination of hydrophilic and hydrophobic solvents (NMP and Triacetin). When compared to other formulations, ISM had the lowest burst release. Both the ISFI and ISM formulations might deliver medications for up to 30 days. Both formulation show good drug entrapment efficiency F4 (87.74%) and EP8 (90.37%) respectively. Both formulations passed all their physicochemical proprieties included visual examination, pH, and injectability respectively. No visible growth of microorganisms was seen in growth media treated with both formulations after 30 days. The injection site (on the skin) and adjacent muscles showed no symptoms of irritation. It was confirmed when the results were compared to those of the control group. There was no hyperemia, discoloration, or necrosis at the site and no sign of irritation by both formulations. In the case of ISM (EP8), drug release follows zero order kinetics with an R2 value of 0.9814 and ISFI (F4) follows Korsmeyer peppas and both transport drug through Fickian diffusion mechanism. Both formulations were found to, be stable. Hence, Long-acting Levothyroxine sodium formulations (ISFI & ISM) may be a superior option for hypothyroidism treatment.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • EVALUATION OF PHARMACOPOEIA COMPLIANCE OF SOME ESSENTIAL OILS IN THE
           MARKET

    • Authors: Burçin ERGENE; Damla HADDUR, Melek KARAASLAN, Hediye Kamuran İLERİ ÖZLER, Gülçin SALTAN İŞCAN
      Abstract: Objective: Essential oils are mixtures, which are obtained from natural sources and induce some physiological effects in the body. These effects vary due to the chemical content of the essential oil. Therefore, selection of essential oils to be used is extremely important in order to see the expected effect. It is not always possible to obtain accurate information about the source and quality of essential oils sold in the market. Essential oils with known chemical content or pharmacopoeial quality are preferred as therapeutic agents in phytotherapy and aromatherapy. These oils are effectively used in mental and physical disorders such as headache, pain, insomnia, eczema, stress-induced anxiety, depression and indigestion.Material and Method: In the content of current study, pharmacopoeia analyses of a total of 51 essential oils of 16 brands sold in the market, which comprise 11 lavender essential oil, 8 rosemary essential oil, 10 lemon essential oil, 8 peppermint essential oil, 9 bergamot essential oil and 6 basil essential oil samples, were conducted. Analysis conditions were determined in accordance with the monographs of Turkish Pharmacopoeia (2017) for lavender, rosemary, peppermint and lemon essential oils; French Pharmacopoeia for bergamot essential oil (1991), and AFNOR French Standards for basil essential oil. Results for basil were also compared with reference values in Randriamiorisoa, 1995 (Manuel Rapide Et Utile Pour Producteurs D'Huiles Essentielles).Result and Discussion: In the light of the data obtained as a result of the pharmacopeia analyses conducted with the samples obtained from the market; it was observed that 3 of the lavender essential oil samples and 1 of the rosemary essential oil samples possess full compliance with the pharmacopoeia, while the other essential oil samples did not fully meet the desired specifications. The results of the pharmacopoeia analysis of the essential oil samples revealed that many oils on the market do not meet the standards of pharmacopoeia.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • CELL INCORPORATION STUDY OF [99mTc]Tc-NAB-PACLITAXEL ON HUMAN COLORECTAL
           ADENOCARCINOMA CELL LINE

    • Authors: Meliha EKİNCİ; Derya İLEM-ÖZDEMİR
      Abstract: Objective: The development of new radiopharmaceuticals capable of specifically imaging cancer is an important research area. For this reason, the aim of this study is to investigate cell binding of novel developed nanoradiopharmaceutical ([99mTc]Tc-nab-PTX) on HT-29 cell line (human colorectal adenocarcinoma cells).Material and Method: In this study, nab-PTX was labeled with [99mTc]Tc, and labeling efficiency and in vitro stability were investigated by radioactive thin layer chromatography (RTLC). Then, cell incorporation of [99mTc]Tc-nab-PTX was performed using HT-29 cell line.Result and Discussion: According to obtained results, nab-PTX was labeled with high radiochemical purity (>99%). The [99mTc]Tc-nab-PTX was found to be stable in saline for 6-h, and in cell medium up to 2-h. It was determined that [99mTc]Tc-nab-PTX had a greater cell binding activity on HT-29 cells than R/H-[99mTc]NaTcO4 at 30 min. The results were found to be promising for future in vivo studies with [99mTc]Tc-nab-PTX.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • MUCOADHESIVE ORODISPERSIBLE FILM FORMULATIONS OF RASAGILINE MESYLATE FOR
           PARKINSON TREATMENT

    • Authors: Meliha GÜNEŞ; Gökçe TURAN, Armağan DÖNMEZER, Fadime AYDIN KÖSE, Kevser Özgen ÖZER, Sinem Yaprak KARAVANA
      Abstract: Objective: The article is included formulation studies and in vitro evaluation of orally dispersible Rasagiline mesylate (RM) orodispersible films (ODFs) for non-oral treatment of Parkinson's Disease. RM undergoes extensive hepatic biotransformation and is a highly selective and irreversible MAO-B inhibitor. It is metabolized in the liver and has an oral bioavailability of approximately 36% and a half-life of 3 hours. These properties suggest that RM may be an excellent candidate for buccal drug delivery.Material and Method: ODFs of RM were prepared using PEO by the solvent casting method. While evaluating these formulations, parameters such as appearance, weight homogeneity, thickness, surface pH, drug content, swelling ratio, tensile strength, mucoadhesion, in vitro drug release studies and also stability were considered.Result and Discussion: Obtained results show that ODFs are an effective and viable approach for RM delivery and may be a new alternative to existing oral delivery systems for Parkinson's treatment.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • INTEGRATED BIOINFORMATIC ANALYSIS TO EVALUATE TARGET GENES AND PATHWAYS IN
           CHRONIC LYMPHOCYTIC LEUKEMIA

    • Authors: Buket ALTINOK GÜNEŞ
      Abstract: Objective: The most common type of leukemia, chronic lymphocytic leukemia (CLL), is characterized by progressive accumulation of monoclonal B cells with a specific immunophenotype in the blood, bone marrow, and lymphoid organ. The goal of this research was to use bioinformatic analysis to comprehend the molecular mechanisms causing CLL and to investigate potential targets for the diagnosis and therapy of CLL.Material and Method: Expression data from CLL patients with accession numbers GSE22529 and GSE26725 were downloaded from the GEO database for bioinformatic analysis. GSE22529 data was studied with samples from 41 CLL patients and 11 healthy groups, while GSE26725 data was studied with blood samples from 12 CLL patients and 5 healthy groups. GEO2R was used to find differentially expressed genes (DEGs) in CLL patient samples and healthy control samples. The DAVID program was used to perform GO and KEGG enrichment analyses on DEGs. Using the Cytoscape software, a protein-protein interaction (PPI) network was created, and hub genes associated with CLL were identified.Result and Discussion: DEGs with p 0.05 and log2FC 0, log2FC>0 were chosen after analysis with GEO2R. In the GSE22529 dataset, 942 genes had higher expression levels in CLL patients compared with controls, while the expression of 1007 genes decreased. In the GSE26725 dataset, CLL patients had lower expression levels for 916 genes compared with controls, while 939 genes showed an increase in expression. 229 DEGs with higher expression levels and 308 DEGs with lower expression levels were found in both sets of data. It has been observed that these common genes, whose expression has changed, are enriched in protein processing in the ER, Chemokine, B-cell receptor, T-cell receptor, protein export pathways. Additionally, DDOST, RPL18, RPL18A, RPL19, RPL31, GNB3, GNB4, GNG11, GNGT1, NEDD8, UBE2M RBX1, FBXO21, SKP1, KLHL9 and CAND1 were identified as the most important genes. Our study's findings demonstrated that newly discovered genes and pathways may be candidates for CLL biomarkers that can be used for both the diagnosis and drug treatment of the disease.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • MOLECULAR MECHANISMS IN BRAIN AGING

    • Authors: Esra ÖZDEK; Sevtap HAN
      Abstract: Objective: In this review, it is aimed to explain the molecular changes that occur with aging in the brain. The molecular mechanisms of brain aging are grouped under the headings of oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, autophagy, inflammation, disruption of lysosome and proteasome function, and impaired DNA repair and focused on these issues.Result and Discussion: Aging is a multifactorial process, possibly resulting from accumulation of damage in organisms and/or decline in maintenance and repair mechanisms. With aging, many structural and functional changes occur in the brain. These changes create a predisposition to diseases such as Alzheimer's and Parkinson's along with neurodegenerative disorders. As the brain ages, its abilities such as learning, decision making and memory decrease. In order to develop therapeutic or protective approaches against brain aging-related diseases and functional disorders, there is a need to elucidate the molecular-level mechanisms of brain aging.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • INVESTIGATION OF THE MICROBIOLOGICAL CONTAMINATION OF USED LIPSTICKS AND
           MASCARAS

    • Authors: Kübra YAZICI; Müjde ERYILMAZ
      Abstract: Objective: Carbon and nitrogen sources, minerals, growth factors in the composition of cosmetic products, and environmental conditions such as convenient acidic environment and humidity constitute the suitable environment for microbial growth. Microbiological contamination of these products is important in terms of both posing a risk to consumer health and causing economic losses due to changes occurring in the product. This study aimed to examine the lipstick and mascara samples used by consumers in terms of microbiological contamination.Material and Method: Thirty lipsticks and thirty mascaras used by consumers were investigated for microbiological contamination. The samples were evaluated according to the microbiological limits specified in the European Standard EN ISO 17516. Contaminant bacteria were identified by VITEK® 2 Compact (bioMérieux, France).Result and Discussion: According to the results obtained, it was determined that only one of the tested mascara samples and four of the lipstick samples did not comply with the specified microbiological limit values. Staphylococcus sciuri was the contaminant bacterium determined in the mascara sample. In addition, Kocuria kristinae, Streptococcus mitis, Streptococcus oralis, Streptococcus alactolyticus, Rothia mucilaginosa, Rothia dentocariosa were detected in lipstick samples. All the bacteria detected as contaminants are Gram-positive, most of which are the members of the mouth, throat, respiratory, and skin microbiota. The contamination may have been caused by the inappropriate use of consumers, such as using the same product by more than one person, contamination of saliva, and not paying attention to hand hygiene.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS IN PHARMACIST AND PHARMACY
           PERSONNEL

    • Authors: Halil BAL; Sulhiye YILDIZ
      Abstract: Objective: The aim of this study was to determine the Staphylococcus aureus (S. aureus) nasal carriage rates and risk factors in pharmacist and pharmacy personnel.Material and Method: 300 nasal swabs were collected from volunteers (pharmacist and pharmacy personnel) working in pharmacies in Ankara, Turkey. Samples were identified as S. aureus by phenotypic methods. Methicillin resistance of the strains was determined in accordance with the recommendations of the Clinical and Laboratory Standards Institute (CLSI) by the disk diffusion method and the presence of the mecA gene was investigated by Polymerase Chain Reaction (PCR). Volunteers were asked to answer some questions (age, sex etc.) and risk factors for nasal S. aureus carriage were investigated.Result and Discussion: S. aureus was detected in 64 (21.3%) of 300 samples and of which 4 (1.3%) were identified as Methicillin Resistance Staphylococcus aureus (MRSA). S. aureus carriage rates were found to be 25.7% in pharmacist and 20% in pharmacy personnel. There was no significant difference between these two groups (p>0.05). A significant difference was found between some risk factors (smoking, diabetes, and outpatient treatment in hospital within the past year) and nasal S. aureus carriage (p<0.05). We think that compliance with hand hygiene and effective infection control policies can reduce the rates of S. aureus and MRSA carriage.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
  • A YOUTH VIEW ON INTERPROFESSIONAL EDUCATION: STUDENT OPINIONS ON
           SIMULATION PRACTICES

    • Authors: Bilge SÖZEN ŞAHNE; Elif ULUTAŞ, Leyla YUMRUKAYA, Melih ELÇİN, Selen YEĞENOĞLU
      Abstract: Objective: In this study, we aimed to bring together the pharmacy and pharmacy technician students via interprofessional simulation practices, to know each other and to discover their opinions about this practice.Material and Method: Standardized patient encounters were conducted by the participation of 27 pharmacy and 51 pharmacy technician students within this study. Thereafter, the written feedback of the students was obtained, and the qualitative findings were analysed with MaxQDA v11.Result and Discussion: As a result, four main themes entitled as "Interaction in the pharmacy", "Task sharing", "Educational outputs" and "Physical facilities" emerged. In this research study, which has overlapping findings with similar studies in pharmacy field, we determined that the evaluations of the students are important for establishing strong basis on interprofessional collaboration. However, we believe that updating the undergraduate curriculum in the light of our study results will affect future professional practices in a positive manner.
      PubDate: Fri, 20 Jan 2023 00:00:00 +030
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 3.214.216.26
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-