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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted alphabetically
Microbial Drug Resistance     Hybrid Journal   (Followers: 3)
Molecular Informatics     Hybrid Journal   (Followers: 5)
Molecular Pharmacology     Hybrid Journal   (Followers: 2)
Molekul     Open Access   (Followers: 1)
Natural Product Communications     Open Access  
Nature Reviews Drug Discovery     Full-text available via subscription   (Followers: 310)
Naunyn-Schmiedeberg's Archives of Pharmacology     Hybrid Journal  
NeuroMolecular Medicine     Hybrid Journal  
Neuropharmacology     Hybrid Journal   (Followers: 5)
Neuropsychopharmacology     Hybrid Journal   (Followers: 17)
Neuropsychopharmacology Reports     Open Access  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Drug Design & Delivery     Open Access  
OA Medical Hypothesis     Open Access  
Obesity Facts     Open Access   (Followers: 8)
Open Pharmacoeconomics & Health Economics Journal     Open Access   (Followers: 1)
Open Pharmacology Journal     Open Access  
OpenNano     Open Access   (Followers: 1)
Orbital - The Electronic Journal of Chemistry     Open Access   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Pain and Therapy     Open Access   (Followers: 3)
Particulate Science and Technology: An International Journal     Hybrid Journal   (Followers: 1)
PDA Journal of Pharmaceutical Science and Technology     Full-text available via subscription   (Followers: 33)
Pediatric Drugs     Full-text available via subscription   (Followers: 3)
Pediatric Pharmacology     Open Access   (Followers: 1)
Pharmaceutica Analytica Acta     Open Access  
Pharmaceutical Biology     Open Access  
Pharmaceutical Care-La Farmacoterapia     Open Access  
Pharmaceutical Chemistry Journal     Hybrid Journal  
Pharmaceutical Development and Technology     Hybrid Journal   (Followers: 19)
Pharmaceutical Executive     Full-text available via subscription   (Followers: 2)
Pharmaceutical Fronts     Open Access   (Followers: 9)
Pharmaceutical Historian     Open Access  
Pharmaceutical Journal     Free   (Followers: 8)
Pharmaceutical Journal of Sri Lanka     Open Access  
Pharmaceutical Medicine     Full-text available via subscription   (Followers: 4)
Pharmaceutical Nanotechnology     Hybrid Journal  
Pharmaceutical Patent Analyst     Full-text available via subscription   (Followers: 3)
Pharmaceutical Research     Hybrid Journal   (Followers: 93)
Pharmaceutical Statistics     Hybrid Journal   (Followers: 15)
Pharmaceutical Technology     Full-text available via subscription   (Followers: 6)
Pharmaceuticals     Open Access   (Followers: 4)
Pharmacia     Open Access  
Pharmaciana     Open Access  
PharmacoEconomics     Full-text available via subscription   (Followers: 25)
PharmacoEconomics & Outcomes News     Full-text available via subscription   (Followers: 2)
PharmacoEconomics German Research Articles     Full-text available via subscription  
PharmacoEconomics Spanish Research Articles     Hybrid Journal   (Followers: 1)
Pharmacoepidemiology and Drug Safety     Hybrid Journal   (Followers: 33)
Pharmacogenetics and Genomics     Hybrid Journal   (Followers: 1)
Pharmacogenomics     Hybrid Journal   (Followers: 7)
Pharmacogenomics and Personalized Medicine     Open Access   (Followers: 2)
Pharmacogenomics Journal     Hybrid Journal   (Followers: 5)
Pharmacognosy Communications     Partially Free  
Pharmacognosy Magazine     Open Access   (Followers: 2)
Pharmacognosy Research     Open Access   (Followers: 2)
Pharmacological Reports     Hybrid Journal  
Pharmacological Research     Hybrid Journal   (Followers: 1)
Pharmacological Research - Modern Chinese Medicine     Open Access  
Pharmacological Reviews     Hybrid Journal   (Followers: 2)
Pharmacology     Full-text available via subscription  
Pharmacology & Therapeutics     Hybrid Journal   (Followers: 3)
Pharmacology & Pharmacy     Open Access   (Followers: 1)
Pharmacology Biochemistry and Behavior     Hybrid Journal   (Followers: 2)
Pharmacology Research & Perspectives     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacopsychiatry     Hybrid Journal   (Followers: 3)
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy     Hybrid Journal   (Followers: 37)
Pharmactuel     Open Access   (Followers: 1)
Pharmacy     Open Access   (Followers: 4)
Pharmacy & Pharmacology     Open Access   (Followers: 1)
Pharmacy Education     Full-text available via subscription   (Followers: 11)
Pharmacy Practice (Internet)     Open Access   (Followers: 8)
Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
PharmaNutrition     Hybrid Journal   (Followers: 3)
PharmaTutor     Open Access  
Pharmazeutische Industrie     Full-text available via subscription   (Followers: 9)
Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 11)
Pharmazie in Unserer Zeit (Pharmuz)     Hybrid Journal   (Followers: 11)
Physiology International     Full-text available via subscription   (Followers: 3)
Plant Products Research Journal     Full-text available via subscription  
Planta Medica     Hybrid Journal   (Followers: 4)
Planta Medica International Open     Open Access  
Prescriber     Hybrid Journal   (Followers: 9)
Progress in Neuro-Psychopharmacology and Biological Psychiatry     Hybrid Journal   (Followers: 8)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Psychopharmacology     Hybrid Journal   (Followers: 15)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Redox Report     Open Access  
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 41)
Research & Reviews : A Journal of Drug Design & Discovery     Full-text available via subscription  
Research & Reviews : A Journal of Pharmaceutical Science     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacognosy     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacology     Full-text available via subscription   (Followers: 1)
Research in Pharmaceutical Sciences     Open Access   (Followers: 3)
Research in Social and Administrative Pharmacy     Hybrid Journal   (Followers: 3)
Research Journal of Pharmacognosy     Open Access  
Research Results in Pharmacology     Open Access  
Reviews of Physiology, Biochemistry and Pharmacology     Hybrid Journal   (Followers: 4)
Reviews on Clinical Pharmacology and Drug Therapy     Full-text available via subscription  
Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Revista Cubana de Plantas Medicinales     Open Access   (Followers: 1)
Revista de Ciências Farmacêuticas Básica e Aplicada     Open Access  
Revista Mexicana de Ciencias Farmaceuticas     Open Access  
Revue de Médecine et de Pharmacie     Full-text available via subscription  
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Saudi Pharmaceutical Journal     Open Access  
Scandinavian Journal of Clinical and Laboratory Investigation     Hybrid Journal   (Followers: 7)
Scientia Pharmaceutica     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Seminars in Oncology Nursing     Full-text available via subscription   (Followers: 10)
Separation Science plus (SSC plus)     Hybrid Journal  
Side Effects of Drugs Annual     Full-text available via subscription   (Followers: 2)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 6)
Substance Abuse : Research and Treatment     Open Access   (Followers: 5)
Suchttherapie     Hybrid Journal   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 5)
SynOpen     Open Access  
The Botulinum J.     Hybrid Journal  
The Brown University Psychopharmacology Update     Hybrid Journal   (Followers: 2)
The Medical Letter     Full-text available via subscription   (Followers: 18)
The Pink Sheet     Full-text available via subscription   (Followers: 12)
The Pink Sheet Daily     Full-text available via subscription   (Followers: 4)
Therapeutic Advances in Drug Safety     Open Access   (Followers: 3)
Therapeutic Advances in Psychopharmacology     Open Access   (Followers: 4)
Therapeutic Advances in Vaccines     Hybrid Journal   (Followers: 1)
Therapeutic Drug Monitoring     Hybrid Journal   (Followers: 3)
Therapeutic Innovation & Regulatory Science     Hybrid Journal   (Followers: 7)
Thérapie     Full-text available via subscription   (Followers: 1)
TheScientist     Free   (Followers: 5)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Toxicological Research     Hybrid Journal  
Toxicological Sciences     Hybrid Journal   (Followers: 11)
Toxicology     Hybrid Journal   (Followers: 18)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 24)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Toxicology in Vitro     Hybrid Journal   (Followers: 11)
Toxicology International     Full-text available via subscription   (Followers: 5)
Toxicology Letters     Hybrid Journal   (Followers: 15)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 7)
Toxicology Research     Partially Free   (Followers: 8)
Toxicon     Hybrid Journal   (Followers: 5)
Toxicon : X     Open Access  
Toxin Reviews     Hybrid Journal  
Translational Psychiatry     Open Access   (Followers: 14)
Trends in Peptide and Protein Sciences     Open Access  
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 19)
Tropical Journal of Pharmaceutical Research     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Vascular Pharmacology     Hybrid Journal   (Followers: 2)
World Mycotoxin Journal     Hybrid Journal   (Followers: 3)
Yakugaku Zasshi     Open Access   (Followers: 1)
Zeitschrift für Phytotherapie     Hybrid Journal   (Followers: 1)
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
Фармацевтичний часопис     Open Access  

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Journal of Faculty of Pharmacy of Ankara University
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1015-3918 - ISSN (Online) 2564-6524
Published by Ankara University Homepage  [5 journals]

    • Authors: İsmail ÇELİK; Meryem EROL, Ebru UZUNHİSARCIKLI, Ufuk İNCE
      Abstract: Objective: SARS-CoV-2 is a pandemic virus characterized by upper respiratory tract infection and can range from mild symptoms to severe complications. In this case, drug repurposing and computer-aided studies have become very important to find emergency solutions. In this study, drug-target interactions on three nonstructural protein structures of SARS-CoV-2 of 8820 drug candidates or drug molecules obtained from the DrugBank database were analyzed.Material and Method: Comprehensive virtual screening and molecular docking studies from 8820 drug molecules or candidates obtained from the DrugBank database were performed on the RNA binding protein, 2'-O-methyltransferase, and endoribonuclease of SARS-CoV-2; and potential drug candidates were determined for each target. Virtual screening studies have been done with High-Throughput Virtual Screening (HTVS), Standard Precision (SP), Extra Precision (XP), and Molecular Mechanics Generalized Born Surface Area (MM-GBSA). Also, information about the clinical findings, transmission, pathogenesis, and treatment of SARS-CoV-2 has been given.Result and Discussion: Drug-target interactions on three nonstructural protein structures of SARS-CoV-2 of 8820 drug candidates or drug molecules obtained from the DrugBank database were analyzed. Potential compound recommendations for each drug target were presented. Information was given about key amino acids where active sites of drug target proteins interact with ligands. This study is expected to be useful in target-based drug development studies on the proteins of SARS-CoV-2.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Tuğçe İNCE KÖSE; Ayşe Mine GENÇLER ÖZKAN
      Abstract: Objective: Viruses are agents that can infect all kinds of living organisms, and the most important hosts are humans, animals, plants, bacteria and fungi. Viral diseases are responsible for serious morbidity and mortality worldwide, are a major threat to public health, and remain a major problem worldwide. The recently prominent Coronaviruses (CoVs) within this group belong to the Coronaviridae family, subfamily Coronavirinae, and are large (genome size 26−32 kb), enveloped, single-stranded ribonucleic acid (RNA ) viruses that can infect both animals and humans. The world has experienced three epidemics caused by betaCoVs in the last two decades: SARS in 2002−03, MERS in 2012, and COVID-19, first identified in 2019. COVID-19 continues to be our current health problem and studies on the subject continue.Result and Discussion: The term "antiviral agents" is defined in very broad terms as substances other than virus-containing vaccine or specific antibody that can produce a protective or therapeutic effect for the clearly detectable effect of the infected host.Nature has the potential to cure humanity's helplessness against viruses with many different plant species with strong antiviral effects. During the screening of plants with antiviral effects, focusing on plants used in folk medicine is of great importance in terms of maximizing the benefit to humanity - saving time and effort by dealing with valuable ancient knowledge on a scientific basis.In this review, viral diseases and the plants used in these diseases and determined to be effective are mentioned.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Hande YÜCE; Neşe BAŞAK TÜRKMEN, Selinay ŞENKAL, Dilan AŞKIN ÖZEK, Ezgi BULUT, Ayşegül DOĞAN, Songül ÜNÜVAR
      Abstract: Objective: Patulin is a mycotoxin produced by some molds, mainly Aspergillus and Penicillium, and is responsible for mycotoxicosis in animals and humans. Although there are still no detailed data on the antitumor activity of patulin, some reports indicate that it induces cellular apoptosis and toxicity. Our aim in this study is to determine the antiproliferative and antimigration effects of patulin on human liver and lung cancer cells and its effect on gene expressions in apoptotic pathways.Material and Method: HEP3B and A549 cell lines were used to determine the efficacy of patulin in the treatment of liver and lung cancers. Cell lines were exposed to increasing concentrations of patulin (1, 2.5, 5, 10, 25, 50, and 100 µM), followed by determination of cell viability, cell migration, and apoptosis by MTS assay, wound healing assay, and RT-PCR assays.Result and Discussion: Patulin caused a dose-dependent significant decrease in cell viability and cell migration in both cancer cell lines. It also promoted the induction of apoptosis in both cell lines. Our results showed that patulin can significantly reduce tumor growth in human liver and lung cancer cells in vitro.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Nigün ÜNAL
      Abstract: Objective: In the twenty-first century, despite the development in infection management, and improvement of vaccines and therapeutic agents in the field of health, new viral outbreaks that can still be fatal in humans and animals are emerging. The infection of zoonosis COVID-19 from bat origin, the intermediate host of which is still being unclear, has appeared in people who visited animal bazaar in December 2019, in Wuhan, China. The World Health Organization declared this infection a pandemic in February 2020. Millions of people have been affected by this pandemic. The fight against the pandemic has had a great economic cost and continues to do so. Even people have changed their lifestyle. In this context, there have been concerns about companion animals with COVID-19 transmission, from human to animal or animal to human. The purpose of this review was to examine the studies on the presence and transmission of COVID-19 in companion animals such as cats, dogs, hamsters and horses.Result and Discussion: It has been reported in studies that most of the companion animals (cat, dog and hamster) were susceptible to SARS-CoV-2, and humans could be a source of infection for them. However, the potential role of companion animals in transmission to humans is not fully known. It is clear from this pandemic that the necessity of epidemiological investigation of infectious agents, especially zoonotic ones, in one health concept has emerged once again.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Gözde YENİCE ÇAKMAK; Ahmet Özer ŞEHİRLİ
      Abstract: Objective: Behçet's Disease (BD) is a multisystemic inflammatory disease which courses with relapses and characterized by four major symptoms of oral aphthous ulcers, genital ulcers, skin lesions and ocular lesions; and five minor symptoms including joint involvement, gastrointestinal ulcers, epididymitis, vascular lesions and neurological involvement. Treatment in BD varies according to the clinical course of age at which the disease begins, gender, the organs involved and the clinical course of the disease; therefore, it should be performed according to the person and the symptoms. While empirical treatment of BD is still continuing; recently, effective protocols have been implemented due to the pathogenesis of the underlying disease that is better defined and many broad-spectrum therapeutic agents have been presented for the treatment. This review is presented to bring together the specific treatment procedures applied during the progression of the disease.Result and Discussion: Although there is no specific treatment strategy for BD, which is an inflammatory disease characterized by local and systemic involvements, treatment procedures range from local corticosteroids to monoclonal antibodies, determined by the type and severity of symptoms. Studies are still continuing on diseases affecting the vascular and gastrointestinal system in BD. Conventional immunosuppressive agents, including corticosteroids, colchicine and azathioprine, and cyclosporine are used in the treatment of BD. Recently, tumor necrosis factor (TNF) inhibitors have become available for a variety of rheumatic diseases, and published data indicate that TNF inhibitors represent a significant therapeutic advance for patients with severe and resistant disease as well as those with contraindications or intolerance to these therapies.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Jale AKGÖL; Ayşegül KÖROĞLU
      Abstract: Objective: Scabies are an itch and contagious ectoparasite that is common around the World. There is the causative Sarcoptes scabiei var. hominis. It can affect people of all ages, sexes, geographies and cultures. It is endemic in developing countries, tropical and subtropical countries. It can cause epidemics in large crowds and environments where hygiene cannot be maintained. Topical and oral options for treatment are limited. Drugs such as Permethrin, Benzyl Benzoate, Sulfur Ointments, Lindan, Ivermectin cannot be applied to all populations at risk due to their toxic effects, infants, children, pregnant women, and lactation-related restrictions. When scabies are not treated, the addition of secondary infections such as pyoderma and impetigo, which are seen especially in the pediatric age group, increases the burden of the disease. For that reason, the search for drugs with less toxic effects keeps the interest in plants still alive.Result and Discussion: In all cases of sporadic or epidemic, effective treatment of scabies is essential to prevent to spread. Successful treatment depends on the correct administration of the medication, the inclusion of additional approaches to control complications and symptoms and the taking of preventive measures. In this review, scabies, their treatment, drugs used, new drugs with the potential to be used and traditionally used plants were examined. It has been determined that 49 taxa that are grown, known and have the potential to grow in our country are used in the treatment of scabies.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Sultan PEKACAR; Didem DELİORMAN ORHAN
      Abstract: Objective: Pistacia is a genus with widespread distribution throughout the Mediterranean basin, belonging to the Anacardiaceae family, which includes species such as P. lentiscus. Various parts of the P. lentiscus species are used in traditional medicine for the treatment of many diseases. In this review, comprehensive information about the botanical features, traditional uses, phytochemical content and pharmacological activities of P. lentiscus has been tried to be summarized.Result and Discussion: Literature surveys have shown that this species has been evaluated for a wide variety of pharmacological activities, including antioxidant, antimutagenic, antimicrobial, antiviral, anti-inflammatory, gastrointestinal diseases, effects on liver and serum biochemical parameters, antiatherosclerotic and antidiabetic, antiparasitic, antitumor, anticholinesterase, neuroprotective and wound healing activities. P. lentiscus contains various phytochemical components such as terpenoids, phenolic compounds, fatty acids and sterols. As a result of the research, it was concluded that the P. lentiscus species is an important resource for the development and commercialization of natural origin drugs in various pharmaceutical forms, but more preclinical and clinical studies are needed to better elucidate the risk factors.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Ezgi AYDIN; Ali AYDIN, Gizem ÇETİNER, Gülşah EREL AKBABA
      Abstract: Objective: Nanoparticular systems such as polymeric and lipidic nanoparticles, which are frequently used in synthetic, biological and biotechnological drug delivery, struggle to meet clinical expectations at the desired level. Nature-inspired biomimetic nanocarriers developed as an innovative approach, are increasingly included in studies due to their high biocompatibility, low toxicity, and natural targeting capabilities. The aim of this review is to contribute to the development of innovative pharmaceutical carrier system by addressing the current studies in the field of biomimetic nanocarriers.Result and Discussion: Among the most commonly used biomimetic systems are virus-based, mammalian cell-based and bacteria-fungi-based nanocarrier systems. The effort to understand these systems that nature offers us could take us further in carrier system research. Moreover, there may be potential for more successful nanocarrier systems to be developed by combining the advantages of synthetic systems such as controllability and mass production with the high cellular uptake and biocompatibility functions of biological systems. Thus, the role of biomimetic systems in the transport of proteins, genes and other therapeutic agents will increase.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Songul TEZCAN
      Abstract: Objective: Colon cancer is the third most common cancer type globally and usually occurs at advanced ages. Since the risk of comorbid diseases may also increase with age, colon cancer patients have an increased risk of polypharmacy. Hypertension, chronic obstructive pulmonary disease, diabetes, and cardiovascular disease are the frequently seen comorbidities in cancer patients. Patients who are elderly, have comorbid conditions, and are taking two or more medications are at higher risk for drug-drug interactions (DDIs). Additionally, cancer patients frequently use many drugs such as supportive care drugs for the treatment of side effects of cytotoxic drugs. DDIs may cause therapeutic failure or potentially serious adverse events. determination and evaluation of DDI levels identify the most suitable rational therapy for cancer patients.Result and Discussion: This study has reviewed the drugs used to treat colon cancer (Capecitabine, Fluorouracil, Irinotecan, Oxaliplatin, Bevacizumab, Ziv-Aflibercept, Nivolumab, Pembrolizumab, Ramucirumab, Regorafenib, Larotrectinib, Dabrafenib, Trametinib, Trifluridine and tipiracil, and Encorafenib) and determined the possible drug-drug interactions. This study will help the pharmacists and clinicians to evaluate possible interactions.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Ahmet Hüsamettin BARAN
      Abstract: Objective: Parkinson’s disease, the second most common neurodegenerative disorder after Alzheimer’s, is a progressive neurodegenerative disease characterized by tremor, rigidity, bradikinesis and postural instability. Environmental and genetic factors contribute to the pathophysiology of this disease. The pioneer of dopamine, L-DOPA, remains the gold standard of pharmacotherapy. Although current therapeutic options are clinically beneficial, since parkinson’s disease is a progressive disorder, all drugs used in treatment decline over time and increase in side effects.Result and Discussion: Recent studies have shown that responses to antiparkinsonian drugs and their side effects exhibit significant interpersonal variability. Pharmacogenetics is a rapidly evolving and very promising field of research aiming to identify genetic markers associated with drug response. Studies in pharmacogenetics have shown that interpersonal genetic differences largely determine the response to drugs used to treat parkinson’s disease. Data obtained in this area will not only have the potential to present valuable therapeutic strategies for antiparkinson treatment, but also increase the probability of successful drug discovery. In this article, compiled studies to identify the role of genetic polymorphisms in better describing the variability in response to antiparkinson therapy and optimizing the pharmacotherapy of parkinson’s disease.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Burçin MERSİN; Gülçin SALTAN İŞCAN
      Abstract: Objective: Moringa oleifera Lamarck is a plant grown in Middle East, Africa and Asian countries, where seeds and leaves of the plant are consumed as food in these countries.Result and Discussion: The leaf and seed parts of the plant are very rich in phytochemicals; high content of flavonoids, glucosinolates, alkaloids, phenolic acids, terpenes, sterols, vitamins, minerals, amino acids and fatty acids. As for the oil obtained from the seeds; It is seen as an alternative food source to olive oil because it is very rich in essential fatty acids omega 3, 6 and 9. All parts of the plant (leaves, seeds, roots and flowers) were found suitable for human and animal consumption. However, it is known that the plant is also used in non-food areas such as water treatment, use as biodiesel, and cosmetics sector. There are scientific studies published in internationally respected journals about the biological effects of plant. The researches revealed that, phytochemicals contained in the plant have proven their antioxidant, antimicrobial, anticancer, antidiabetic and preventive effects on cardiovascular risks.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Fuat KARAKUŞ; Burak KUZU
      Abstract: Objective: The aim of this study was to determine which metabolite plays a role in the cardioprotective effect of dexrazoxane, and also to identify alternative compounds to dexrazoxane since clinical use of dexrazoxane is limited. For this purpose, the interactions of dexrazoxane and its three metabolites (B, C, and ADR-925), as well as the compounds, which reported to be inhibitors for topoisomerase VI (prototype of human DNA topoisomerase II beta), with human DNA topoisomerase II beta were investigated by molecular docking. Afterwards, the theoretical ADMET properties of all these compounds were determinedMaterial and Method: The molecular structures were optimized by Gaussview 05 and Gaussian 03 package programs. AutoDock 4.2 software was used for molecular docking studies and the docking complexes were analyzed in 2D and 3D using the Discovery Studio Client 4.1 program. The pkCSM online program was used to calculate the theoretical ADMET parameters.Result and Discussion: As a result of molecular docking studies, it was determined that the B metabolite of dexrazoxane has a higher binding potential to human DNA topoisomerase II beta compared to both dexrazoxane and its other metabolites. The binding potentials of other compounds reported in the literature to human DNA topoisomerase II beta were radicicol>quinacrine>purpurin>9-Aminoacridine>hexylresorcinol, respectively.The results showed that the B metabolite of dexrazoxane plays an important role in the cardioprotective mechanism of action of dexrazoxane against anthracycline cardiotoxicity. In addition, it has been determined that other compounds, except purpurin, have the potential to cause toxicity.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Gozde YALCİN; Birsen HUYLU
      Abstract: Objective: In this study, it was aimed to carry out computational studies for the development of new molecules for the inhibition of the cyclophilin D (CypD) receptor, which causes the disability of mitochondrial function in multiple sclerosis (MS) disease.Material and Method: Pharmacophore modeling study was applied via the PharmaGist Web server to the CypD inhibitors detected by the literature search. According to the best pharmacophore models from PharmaGist, 80 molecules were obtained from the ZINCPharmer database, and in silico ADME/Toxicology analysis was applied to these molecules. Then, molecular docking was performed with the ligands that gave the best results as a result of ADME/Tox analyses with the Autodock Vina program.Result and Discussion: ZINC00390492 molecule shows the best binding affinity and binding profile with both CypD, Sphingosine-1-phosphate receptor 1. It has been demonstrated that this molecule may be a lead molecule for the treatment of MS. 
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Merve Eylül KIYMACI; Duygu ŞİMŞEK, Nurten ALTANLAR
      Abstract: Objective: Yarrowia lipolytica is an aerobic dimorphic yeast that produces various metabolites such as enzymes, organic acids, proteins, surfactants and has industrial potential in some biotransformation and bioremediation reactions. To be a preliminary study to industrial productions, in present study it was aimed to isolate Y. lipolytica strain from yoghurt cream, perform its molecular characterization and investigate the lipolytic activity.Material and Method: A total of 10 samples were taken from the homemade yoghurt cream obtained by fermented milk from local dairy producers in Ankara. Yeast-Peptone-Glycerol (YPG) broth and Yarrowia lipolytica Distinctive (YLD) agar media were used for isolation of the species. Species-level identification was carried out by ITS-Polymerized chain reaction analysis. Lipolytic activity was determined with Rhodamine-B/Olive Oil Agar nutrient medium procedure.Result and Discussion: Yeast colonies were isolated from homemade yoghurt creams by growing in YPG broth. Yeasts were stained with Gram staining method and Gram-positive stained ones were inoculated on YLD agar. At the end of the incubation period, the brown pigmented colony growing on YLD agar was selected as Yarrowia species. According to the molecular characterization results the brown pigmented colony was identified as Yarrowia lipolytica with a total of 358 bases, 100% sequence matching ratio and 100% similarity ratio and the strain was determined as lipase positive. The development of the Y. lipolytica strain isolated in our study as a producer culture that can be used in industrial production should be supported by further studies to benefit from its various properties.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Kenan Can TOK; Şeyda YAYLA
      Abstract: Objective: Consolida thirkeana (Boiss.) Bornm. (Ranunculaceae) is considered endemic to Turkey and identified by pale lilac flowers, sessile follicles, and laciniae linear leaves. The genus Consolida can often be confused morphologically with Delphinium, in this respect, members of the genus Consolida need chemotaxonomic interest. In this study, the phytochemical content of C. thirkeana was clarified by GC/MS analysis.Material and Method: The plant material was collected from Ayaş (Ankara/Turkey). A voucher specimen was deposited in the Ankara University Faculty of Pharmacy Herbarium. The aerial part of the plant was powdered in a grinder. The powdered plant parts were macerated with methanol. The GC-MS analysis of extracts was performed using an Agilent 6890 gas chromatograph equipped with an Agilent 5973N quadrupole mass spectrometer (Agilent, USA). Mass Hunter software (Qualitative Analysis B.07.00) and the NIST Mass Spectral Library (2014) were used for determining and identifying compounds.Result and Discussion: The analysis results of this study showed the presence of 15 compounds in C. thirkeana methanol extract. The extract contains 0.65% Glycoside, 0.68% Fatty acid, 0.91% Acylglycerol, 2.41% Carboxylic acid, 38.5% Sugar, 56.86% Sugar alcohol.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Merve İNCİ ÇAMÇİ; Meral ERDİNÇ, Emre UYAR, İlker KELLE
      Abstract: Objective: Minocycline is a second-generation tetracycline group antibiotic that acts on the central nervous system. Minocycline reduces microglial activation and has anti-inflammatory, anti-apoptotic, and antioxidant properties. Recently, it has been proposed that there is a bidirectional relationship between diabetes and depression and that inflammation is one of the common pathways in their pathophysiology. The effects of minocycline on depression were then investigated. This study aimed to reveal the effects of minocycline alone or in combination with metformin, which is used in the treatment of diabetes, on diabetes-related depression.Material and Method: For this purpose, to establish a human-like type 2 diabetes model in mice, streptozotocin (STZ) (50mg/kg) was administered once a day for five consecutive days after a 4-week high-fat diet. Animals with blood glucose levels ≥200 mg/dl were considered diabetic and employed in this experiment. Minocycline (40 mg/kg), fluoxetine (20 mg/kg), and metformin (200 mg/kg) were given once a day for 7 days two weeks after STZ injection. After the drug injections were completed, an open field test was used to determine locomotor activity and a forced swimming test was used to determine depression level.Result and Discussion: It was concluded that diabetes and the drugs administered did not induce a significant change in locomotor activity, and that the minocycline and minocycline-metformin combination was at least as effective as fluoxetine in treating depression. It is recognized that the initiation of antidepressant effects in a short period is critical for patient adherence to therapy and diabetes prognosis. In conclusion, antidepressant-like effects of subchronic minocycline treatment appear to be potent as classical antidepressants. The mechanisms underlying minocycline's effects on mood should be broadly investigated to increase our understanding of depression and unveil potential novel therapies in depression management.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Ece MİSER SALİHOĞLU; Bolkan ŞİMŞEK, Erdoğan ÇAYIR, Sevgi AKAYDIN
      Abstract: Objective: Antioxidant activities of the plants were significantly affected by their drying methods. In the current study, total phenolic contents and antioxidant activity of aqueous extracts of peppermint (Mentha piperita L.) dried by two different methods, air-dried (AD) and freeze-dried (FD) were measured. The aim was to determine if there were any changes in the antioxidant activity according to the drying method.Material and Method: In order to determine the total phenolic compounds and antioxidant capacity of air-dried (AD) and freeze-dried (FD) mint, were used Folin Ciocalteu, CUPRAC, DPPH, ABTS, DMPD methods.Result and Discussion: Results were evaluated by comparing with the known antioxidant standards, such as gallic acid, trolox, ascorbic acid, and butylatedhydroxyanisole (BHA). The total phenolic contents (TPC) were calculated as 59.9 mg/g GAE for AD plant extract and 58.2 mg/g GAE for FD extract. According to the obtained results from all methods, radical scavenging activities were found to be slightly higher in AD samples than in FD samples. In conclusion, the results show that air-drying does not cause degradation in compounds that contribute to the antioxidant activity of the peppermint. 
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Hayrettin SEÇİLMİŞ; Ebru ÇUBUK DEMİRALAY, Kader POTURCU
      Abstract: Objective: In this study, the thermodynamic protonation constant ((_s^s)〖pK〗_a ) of antifungal azole derivative miconazole and tioconazole were investigated by the reversed-phase liquid chromatography (RPLC) method. Although classical stationary phases are the most commonly used column-packed materials in the analyses of these compounds by the RPLC method, the determination of the pKa value of miconazole and tioconazole with a cyano-based column has not been reported so far.Material and Method: Chromatographic behavior of the selected compounds was determined with Ultra Cyano column (Restek®, 150×3.0 mm I.D, 3µm) which is compatible with hydrophobic compounds. The dependence of the retention times on the acetonitrile content of the mobile phase and the effect of the mobile phase pH on the chromatographic retention was determined for each compound by changing the pH in the range of 3.0-7.50.Result and Discussion: The (_s^s)〖pK〗_a values were determined by a nonlinear regression program. The thermodynamic aqueous pKa ((_w^w)〖pK〗_a ) value of the studied compounds was calculated from the (_s^s)〖pK〗_a value by using the macroscopic parameters (dielectric constant and mole fraction) that play an important role in the solvent properties. The calculated (_w^w)〖pK〗_a values were compared with literature values.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Nilay AKSOY; Nur ÖZTÜRK, Serel ULUSOY, Rashida MUHAMMAD UMAR, Sena OZAYDIN
      Abstract: Objective: Our study aimed to assess the role of pre-graduate pharmacy students’ participation in a diabetic education program on improving diabetic self-care.Material and Method: This study included both a cross-sectional and a longitudinal follow-up. Altinbas University fifth-year pharmacy students gathered relevant information from diabetic patients that visited community pharmacies, under the supervision of their instructor pharmacist. The participants filled out the diabetic self-care scale on their first visit before they were given the education. Patients refilled the same self-care questionnaire after three months. Statistical package for the social science (SPSS) 26 was used for all statistical analysis.Result and Discussion: The study comprised 86 diabetic patients. The second questionnaire results showed significant improvement in all patients. The total diabetic self-care scale scores were improved remarkably after the training session. HbA1c and BMI values decreased significantly. An educational program can improve diabetic self-care and diabetic outcomes. Active participation of final year pharmacy students in patient care can also improve pharmacists' participation and contribution to patient care delivery. 
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Gizem Rüya TOPAL; Merve Eylül KIYMACI, Yalçın ÖZKAN
      Abstract: Objective: In this study, it was aimed to prepare Vancomycin loaded poly(lactic acid-co-glycolic acid) (PLGA) nanoparticles that can be used parenterally in enterococcal infections.Material and Method: In the study, different concentrations of PLGA were used to prepare nanoparticles. Emulsification-solvent evaporation method was used in the preparation of the particles. Particle size and distribution, zeta potential, encapsulation efficiency and yield of the prepared formulations were determined. FTIR analyses were also performed for the formulations. The antibacterial activity was determined as a minimum inhibition concentration by broth microdilution method and as an inhibition zone by disk diffusion method against Enterococcus faecalis ATCC 29212 according to European Committee on Antimicrobial Susceptibility Testing and its effectiveness on bacteria was interpreted by comparing with the pure active substance.Result and Discussion: Particles were successfully prepared by emulsion-solvent evaporation method. Around 300 nm; Particles with a high amount of encapsulated Vancomycin were obtained at PDI values of 0.26-0.28. As a result of the FTIR analysis, it was determined that Vancomycin was loaded into the particle. The MIC values of the prepared PLGA nanoparticles against Enterococcus faecalis ATCC 29212 strain was found to be 4 µg/ml, and the inhibition zone diameters were measured as 15 mm, 15 mm and 16 mm, respectively.
      PubDate: Sun, 29 May 2022 00:00:00 +030

      Abstract: Objective: The aim of the work was the histological study of a corrective influence of sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl) thio) acetate on the state of rats liver under conditions of acute immobilization stress.Material and Method: As an object of research sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl) thio) acetate was used. All substances were injected intragastrically, daily for 5 days in appropriate doses on an empty stomach from 9.00-10.00. 1 hour after the last injection, immobilization 6-hour stress was simulated. The central part of the liver was fixed for further histological examination in 10% formaldehyde solution, dehydrated in alcohols of increasing strength, poured into paraffin.Result and Discussion: The results of the study demonstrate the presence of stress-protective properties of sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl) thio) acetate in the model of acute immobilization stress, which was reproduced for 6 hours. As can be seen from the described and presented microscopic picture, the test sample to some extent reduced the degree of stress damage to the liver. In terms of the positive effect on the histological condition of the liver parenchyma (a more pronounced structural orientation of hepatocytes was noted, their beam structure was contoured, dystrophic changes of hepatocytes are less pronounced, round cell infiltrates and foci of hepatocyte necrosis are absent), sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetate exhibits a stress-protective effect in the model of acute immobilization stress. We can conclude about similarity of activity of the test sample with comparison drug (Mebicar®) at studying of influence on a histologic condition of a liver parenchyma
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Merve Eylül KIYMACI
      Abstract: Objective: The ability of bacteria to develop resistance to existing antibiotics has made the search for new antimicrobials or antimicrobial formulations a matter of urgency. Among drug delivery systems, solid lipid nanoparticles are considered solution-oriented systems with advantages for targeted drug delivery.Material and Method: In this study, the bacterial uptake of SLNs encapsulated with fluorescein into Staphylococcus aureus ATCC 29213 was investigated by a flow cytometry method to be a preliminary study for antibiotic improvement studies.Result and Discussion: It was determined that ~60% of fluorescein-SLNs were taken into S. aureus ATCC 29213 cells within 1h. The results were found to be promising for future studies with antibiotics.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Andrey GOTSULYA; Tetiana BRYTANOVA
      Abstract: Objective: The aim of the work was to develop effective methods for the synthesis of biologically active heterocyclic systems containing pyrrole, indole and 1,2,4-triazole. In this study, firstly fourteen [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles compounds requiring for this study were synthesized.Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, 1H NMR, LC-MS techniques. The biological potential of the synthesized substances was estimated by the molecular docking method.Result and Discussion: An optimal method for the synthesis of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles has been developed. In molecular modeling studies, the compounds were found to be similar to known drugs in some respects. Besides, the interaction of each molecule in the active site of the crystal structures of cyclooxygenase-1, lanosterol 14-α-demethylase, kinases of anaplastic lymphoma were considered as in silico.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Samia HAJJAR; Ali JABER, Milad EL RIACHI, Fadi ABDEL SATER, Edmond CHEBLE
      Abstract: Objective: Cancer is still one of the most fatal diseases that threaten human health. Since the effectiveness of conventional cancer therapies based on chemotherapy, radiotherapy, cytotoxic drugs, and surgery is limited by their toxic effects, new therapies are needed. Secondary metabolites from plants exhibit good biological activities. The effect of solvent polarity and method of extraction on the yield of extraction, and the effect of the solvent extract on the biological activities of Nicotiana tabacum Linn. leaves extracts were evaluated. The essential oil extract of the leaves will be analyzed as well.Material and Method: Samples of tobacco leaves, grown in Lebanon, were the subject of this work. Two methods of extraction in a series of solvents with decreasing polarities were performed. The antitumor activity was evaluated on breast adenocarcinoma MCF7 cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay. The chemical composition analysis was conducted using TLC and GC-MS for essential oil.Result and Discussion: The Nicotiana tabacum extracts exhibit anticancer activities, and it is affected by the solvent used. Moreover, the polarity and method of extraction significantly affect the yield of extraction. These results required further investigations on this plant and must be tested on other cancer cell lines. The TLC analysis of different extracts lead us to suggest the presence of α-4,8,13-duvatriene-1,3-diol, β -4,8,13-duvatriene-1,3-diol and Z-abienol (Z-AB). Totally 19 volatile constituents were detected in N. tabacum and the main components were pentadecanal (47.71 %), biosol (15.88 %), solanone (11.06 %), thymol (5.52 %), damascenone (2.16 %), and β-Caryophyllene (2.19 %). As well as that many studies are required to determine the active principles and their mode of action.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Mert ILHAN; Muhammed Mesud HÜRKUL
      Abstract: Objective: Inula peacockiana, which is called "uzunandızotu" in Turkey, is a stout perennial herbaceous plant with yellow flowers, grow up to 2 m. It is a plant belonging to the Asteraceae family, which has medicinal value. The safe use of medicinal plants depends on their correct diagnosis. The anatomical features of the leaves are valuable in diagnosing plants correctly. In this study, the anatomical features of the basal leaf, petiole and cauline leaf of I. peacockiana were investigated.Material and Method: Plant materials were collected from Van (Turkey). A voucher specimen was deposited in the VANF Herbarium. The samples for anatomical studies were preserved in 70% alcohol. The transverse and surface sections were cutted by hand with razor blade in microscopic preparation form. The chloral hydrate solution was used in microscopic examinations.Result and Discussion: The basal and cauline leaves are dorsiventral and contain cover and glandular hairs. The main vein protrudes outward in the midrib of the both leaves. Different the basal leaf, the cauline leaf contains more glandular hairs on the upper surface and cover hairs on the lower surface. In both leaves, ranunculaceae type stomata were observed in the upper and lower epidermis. The simple arc-shaped petiole includes of numerous separate bundles embedded in the parenchymatous cells. The epidermal layer consist of numerous cover and glandular hairs.
      PubDate: Sun, 29 May 2022 00:00:00 +030

    • Authors: Yasin DARI; Süleyman YUR, Gülmira ÖZEK, Ülkü Dilek UYSAL, Temel ÖZEK
      Abstract: Objective: Determination and comparison of the biological activities of black and white chia seeds in extracts obtained by different extraction techniques.Material and Method: Biological activity studies of extracts obtained by different techniques were determined by applying DPPH radical scavenging potential test, TEAC test and ORAC test. In addition, total phenol and flavonoid amounts were determined in methanolic extract samples.Result and Discussion: In this study, phenol amount was determined as 9.86 mg GAE/g for black seed and 12.69 mg GAE/g for white seed and the total amount of flavonoids was determined as 0.098 mg RE/mL for black chia seed and 0.099 RE/mL for white seed. In addition, considering the antioxidant activity tests, the highest antioxidant activity for TEAC test was found in both black and white seed extracts obtained by the Cold press method, the highest activity for DPPH was in the white seed extracted obtained by the Cold press method, and the highest activity for ORAC test was observed in the white seed extract obtained by the Folch technique.Keywords: Biological activity, chia, DPPH, ORAC, TEAC
      PubDate: Sun, 29 May 2022 00:00:00 +030
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