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- Pharm-Care Tadulako®: Web-Based Design Application to Improve
Pharmaceutical Care Services
Authors: Amelia Rumi, Muhammad Faisal, Nuryani Syarifuddin, Rani Purwanti, Putri Natasya, Serli Serli, Yusriadi Yusriadi, Miski A. Khairinisa
Abstract: Pharmaceutical services recently require new ideas and innovation to provide maximum benefit concerning the pharmacological treatments of patients and taking responsibility for the process of monitoring their therapy. One of the efforts proposed to be implemented by pharmacists is the pharmaceutical care program which is designed to ensure pharmacists are able to monitor safe and effective medication use and also to provide timely access to medicines for the population. Moreover, the application of eHealth in terms of technology is expected to be effective, networked, patient-centered, and accessible for patients. Therefore, Pharm-Care Tadulako® which is a personalized eHealth application designed with key features of pharmaceutical care to enhance communication between pharmacists and patients is presented in this study. Some of the services designed to be provided by this application include electronic medical records, drug reminders, pharmaceutical messenger, clinical data monitoring, and medication analysis. The application was designed using Software Development Life Cycle (SDLC) Waterfall, after which a pilot study was conducted at four pharmacies in Palu City, Centre of Sulawesi, Indonesia, using 30 patients who volunteered willingly to participate in the experiment. It was discovered that 65% out of the 30 patients were aged 26-45 years old out of which 36% were observed to be suffering from hypertension. The Pharm-Care Tadulako® application was found to have a good impact on pharmacists during the process of providing pharmaceutical care services to patients while they were able to monitor their treatment through the five main features of the application.
PubDate: 2023-10-16
DOI: 10.15416/pcpr.v8i2.45759
Issue No: Vol. 8, No. 2 (2023)
- Kratom (Mitragyna speciosa) Leaf Ethanol Extract Showed In Vivo Analgesic
Activity
Authors: Rahmad A. Prasetya, Tri P.L Sudarwati
Abstract: Analgesic drugs like morphine and other opioids exhibit several harmful effects. Thus, the exploration of a new and safer analgesic drug is necessary. Utilizing Indonesia's biodiversity richness, medicinal plants can serve as an alternative source of novel analgesic drugs. Here, we show the analgesic activity of Kratom (Mitragyna speciosa) leaf ethanol extract (KE) in formaldehyde-induced rat (Rattus norvegicus) models. The effect of KE was examined by observing the duration of spontaneous nociceptive behavior such as paw licking or limp leg. The result showed that rats treated with 70 mg/kg KE demonstrated significantly (p<0.01) decreased nociceptive behavior compared to those receiving vehicles. However, a higher KE dose (210 mg/kg) failed to increase the analgesic effect and showed a slight reduction (not significant) compared to the control group. These findings proved that kratom leaf ethanol extract has the potential to alleviate painful conditions.
PubDate: 2023-08-11
DOI: 10.15416/pcpr.v8i2.40727
Issue No: Vol. 8, No. 2 (2023)
- Pharmacokinetic Changes and Dosage Adjustment of Digoxin in Elderly
Patients with Atrial Fibrillation: A Narrative Review
Authors: Mohammed Alfaqeeh, Lanny I. Permatasari, Miski A. Khairinisa, Taofik Rusdiana
Abstract: Digoxin is a cardiac glycoside medication commonly used to control rapid heart rates in Atrial Fibrillation (AF). However, digoxin has a narrow therapeutic range and can be associated with adverse effects, including increased mortality risk, especially in the elderly. Pharmacokinetic changes occur with aging, affecting the way drugs are absorbed, distributed, metabolized, and eliminated from the body. Thus, this narrative review aimed to assess the optimization of digoxin dosing in elderly patients with AF while considering pharmacokinetic changes due to aging. We performed a comprehensive computerized search of relevant English articles and a manual examination of reference lists from primary sources formed the basis of this scoping review. This involved an extensive computerized search of relevant articles in English and a manual search of the reference lists of original articles. The review highlighted the need to carefully monitor digoxin levels in elderly patients due to changes in body composition, protein binding, hepatic clearance, renal excretion, and other factors affecting drug metabolism. Furthermore, we summarized guidelines and recommendations for optimizing digoxin dosing in elderly patients with AF. By shedding light on the intricacies of optimizing digoxin dosing in the elderly with atrial AF and emphasizing the significance of accounting for age-related pharmacokinetic changes, this review offers valuable insights for healthcare practitioners and researchers in the field. Addressing these aspects is crucial to enhancing therapeutic outcomes and minimizing potential risks associated with digoxin therapy in this vulnerable patient population
PubDate: 2023-08-11
DOI: 10.15416/pcpr.v8i2.48284
Issue No: Vol. 8, No. 2 (2023)
- Prescribing Pattern of Vitamins in Dermatologic Disorders at Tertiary Care
Teaching Hospital in Western India
Authors: Zankrut J. Patel, Akanksha Prajapati, Vidhi Thaker, Sumit Patel
Pages: 80 - 92
Abstract: Skin ailments are a major burden in society. It is thought that Vitamins may help in improving skin health and appearance, but their deficiency may cause disease. The data regarding vitamin usage patterns in dermatologic practice in India is lacking. Therefore, the present study has been planned to analyze the prescribing pattern of vitamins. A cross-sectional, observational study was carried out at the outpatient department of dermatology at GCSMCH and RC, Ahmedabad, for 12 months from October 2019 to September 2020. Prescriptions of 500 patients were analyzed for common skin conditions and prescribing patterns. All the data were compiled into Microsoft Office Excel, and a descriptive statistical analysis was conducted. Out of 500 patients, males and females were 226(45%) and 274 (55%), respectively. Most of them had skin appendage-related diseases (28%). Out of the total of 1935 prescribed drugs, 619(31.98%) vitamins were prescribed in 500 patients with an average of 1.23 per prescription, in which the majority of drugs were as fixed-dose combination (FDC). Of 1211 prescribed vitamins, vitamin A was the most commonly prescribed vitamin 197 (39.4%). There is no association between prescribed vitamins and the prevalence of diseases. (p>0.05). However, the P-value is highly significant, suggesting an association between prescribed vitamins and different age groups. (p<0.05). Skin appendage-related diseases are commonest skin ailments. The use of vitamins in skin conditions is very common, particularly in oral formulations, among which the majority were prescribed as FDCs.
PubDate: 2023-05-04
DOI: 10.15416/pcpr.v8i2.40973
Issue No: Vol. 8, No. 2 (2023)
- Effects of Centella Asiatica (L) Urb. on Cognitive Function in Hypothyroid
Mice Offspring
Authors: Miski A. Khairinisa, Mohammed Alfaqeeh, Vinda M. Patricia
Pages: 93 - 101
Abstract: Centella asiatica (C. asiatica) is widely used in traditional medicine due to its numerous health benefits. Among its reputed advantages are improved memory, intelligence, and neural protection. Impairment of cognitive function as a center for memory processing occurs due to perinatal hypothyroidism. Although several studies have shown that C. asiatica extract may improve memory function, the effectiveness of its extract as a memory enhancer for patients with perinatal hypothyroid is less unknown. Therefore, this study aimed to determine the effects of ethanol extract of C. asiatica (EEC) leaf as a memory enhancer in perinatal hypothyroid mice model. C. asiatica leaves were extracted by the decoction method, and the ethanol extract was administered to mice. the hypothyroid mouse model was developed by administering antithyroid agents to pregnant mice from gestational day (GD) 18 to postnatal day (PND) 21. The hypothyroid mice were administered either donepezil 5 mg/kg BW/mL (positive control) or treatment group (EEC 2 mg/kg BW/mL) from PND 21 to PND 35 (14 days). The light-dark test (LDT) and memory tests of offspring were conducted on PND 36. We found that EEC improved the cognition and memory of perinatal hypothyroidism mice. This study contributes to the foundational research for developing memory-enhancing supplement preparations, mainly targeting children with perinatal hypothyroidism.
PubDate: 2023-07-07
DOI: 10.15416/pcpr.v8i2.48162
Issue No: Vol. 8, No. 2 (2023)
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