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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted by number of followers
Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 11)
Pharmazeutische Industrie     Full-text available via subscription   (Followers: 9)
Pharmaceutical Journal     Free   (Followers: 8)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Pharmaceutical Fronts     Open Access   (Followers: 7)
Molekul     Open Access   (Followers: 7)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 6)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 6)
AAPS Open     Open Access   (Followers: 5)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 4)
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 4)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
Canadian Journal of Pain     Open Access   (Followers: 3)
PharmaNutrition     Hybrid Journal   (Followers: 3)
Journal of Drug Delivery Science and Technology     Hybrid Journal   (Followers: 3)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Journal of Pharmacological Sciences     Open Access   (Followers: 3)
Indian Journal of Drugs in Dermatology     Open Access   (Followers: 2)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Current Research in Drug Discovery     Open Access   (Followers: 2)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Pharmacological Research - Modern Chinese Medicine     Open Access   (Followers: 2)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
International Journal of Immunopathology and Pharmacology     Open Access   (Followers: 2)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Journal of Pharmaceutical Sciences and Pharmacology     Full-text available via subscription   (Followers: 2)
Journal of Education and Science     Open Access   (Followers: 2)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 1)
Pediatric Pharmacology     Open Access   (Followers: 1)
Journal of Metabolomics & Systems Biology     Open Access   (Followers: 1)
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
Integrative Medicine International     Open Access   (Followers: 1)
Journal of Applied Pharmaceutical Research     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Farmakoèkonomika : Modern Pharmacoeconomic and Pharmacoepidemiology     Open Access   (Followers: 1)
Separation Science plus (SSC plus)     Hybrid Journal   (Followers: 1)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Journal of Biopharmaceutics Sciences     Open Access   (Followers: 1)
Expert Review of Precision Medicine and Drug Development     Hybrid Journal   (Followers: 1)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian     Open Access   (Followers: 1)
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 1)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
OpenNano     Open Access   (Followers: 1)
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Journal of Pharmaceutical Technology, Research and Management     Open Access   (Followers: 1)
Journal of the American College of Clinical Pharmacy : JACCP     Hybrid Journal   (Followers: 1)
Open Pharmacoeconomics & Health Economics Journal     Open Access   (Followers: 1)
Pharmactuel     Open Access   (Followers: 1)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Medicines     Open Access   (Followers: 1)
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Future Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Journal of Pharmaceutical Health Care and Sciences     Open Access   (Followers: 1)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
Pharmacy & Pharmacology     Open Access   (Followers: 1)
Clinical Complementary Medicine and Pharmacology     Open Access  
Exploratory Research in Clinical and Social Pharmacy     Open Access  
Indonesian Journal of Pharmaceutical Education     Open Access  
Future Drug Discovery     Open Access  
IUPHAR/BPS Guide to Pharmacology CITE     Open Access  
Journal of Applied Pharmaceutical Sciences and Research     Open Access  
Cephalalgia Reports     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacia     Open Access  
Research Results in Pharmacology     Open Access  
Journal of Toxins     Open Access  
Journal of Pharmaceutics & Pharmacology     Open Access  
Natural Product Communications     Open Access  
PharmaTutor     Open Access  
International Journal of Pharmaceutical Sciences and Developmental Research     Open Access  
Toxicological Research     Hybrid Journal  
Current Medical Science     Hybrid Journal  
EUREKA : Health Sciences     Open Access  
Iraqi Journal of Pharmacy     Open Access  
Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Medicine in Drug Discovery     Open Access  
Frontiers in Medical Technology     Open Access  
International Journal of Medical and Pharmaceutical Case Reports     Open Access  
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
Journal of Pharmaceutical Health Services Research     Hybrid Journal  
AboutOpen     Open Access  
Current Protocols in Pharmacology     Hybrid Journal  
Medical Cannabis and Cannabinoids     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Pharmaceutical Journal of Sri Lanka     Open Access  
Isan Journal of Pharmaceutical Sciences (IJPS)     Open Access  
Ciencia e Investigación     Open Access  
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community)     Open Access  
Toxicon : X     Open Access  
International Journal of Pharmaceutics: X     Open Access  
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia     Open Access  
Open Pharmacology Journal     Open Access  
ExRNA     Open Access  
International Journal of Pharmaceutics & Pharmacology     Open Access  
Antibody Therapeutics     Open Access  
Journal of Faculty of Pharmacy of Ankara University     Open Access  
Iraqi Journal of Pharmaceutical Sciences     Open Access  
Journal of Medicinal Botany     Open Access  
Journal of Medicinal Herbs and Ethnomedicine     Open Access  
International Journal of Pharmacokinetics     Hybrid Journal  
Neuropsychopharmacology Reports     Open Access  
Reviews on Clinical Pharmacology and Drug Therapy     Full-text available via subscription  
SynOpen     Open Access  
Matrix Science Pharma     Open Access  
Contract Pharma     Full-text available via subscription  
Journal of Cellular Neuroscience and Oxidative Stress     Open Access  
Istanbul Journal of Pharmacy     Open Access  
Acta Pharmaceutica Indonesia     Open Access  
Indonesian Journal of Pharmacy     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
High-Throughput     Open Access  
Scientia Pharmaceutica     Open Access  
Trends in Peptide and Protein Sciences     Open Access  
Acta Physiologica Hungarica     Full-text available via subscription  
Jurnal Farmasi Sains dan Praktis     Open Access  
Jurnal Kefarmasian Indonesia     Open Access  
Pharmaceutical Historian     Open Access  
Planta Medica International Open     Open Access  
Archives of Razi Institute     Open Access  
Journal of Pharmaceutical Research     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
FarmaJournal     Open Access  
Journal of Negative and No Positive Results     Open Access  
Pharmaciana     Open Access  
Folia Medica Indonesiana     Open Access  
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
International Journal of Pharmacology, Phytochemistry and Ethnomedicine     Open Access  
Фармацевтичний часопис     Open Access  
Ciência Equatorial     Open Access  
Iranian Journal of Pharmaceutical Research     Open Access  
Research & Reviews : A Journal of Drug Design & Discovery     Full-text available via subscription  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Research & Reviews : A Journal of Pharmacognosy     Full-text available via subscription  
Ars Pharmaceutica     Open Access  
Pharmacognosy Communications     Partially Free  
Egyptian Pharmaceutical Journal     Open Access  
Pharmacological Reports     Hybrid Journal  
PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Journal of Nanopharmaceutics and Drug Delivery     Full-text available via subscription  
Journal of Hydrogels     Full-text available via subscription  
Manufacturing Chemist     Full-text available via subscription  
Pharmaceutica Analytica Acta     Open Access  
Journal of Pharmacovigilance     Open Access  
Current Pharmacology Reports     Hybrid Journal  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
International Journal of Herbs and Pharmacological Research     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Research Journal of Pharmacognosy     Open Access  

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Journal Cover
Journal of Medicinal Plants for Economic Development
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2519-559X - ISSN (Online) 2616-4809
Published by AOSIS Publishing Homepage  [32 journals]
  • Acknowledgement to reviewers

    • Authors: Editorial Office
      First page: 1
      Abstract: No abstract available.
      PubDate: 2022-12-15
      DOI: 10.4102/jomped.v6i1.183
      Issue No: Vol. 6, No. 1 (2022)
  • Antibacterial activities and biosynthesis of nanoparticles using hemp

    • Authors: Karishma Singh, Roger M. Coopoosamy, Kubendran K. Naidoo, Jamila K. Adam
      First page: 6
      Abstract: Background: The use of plants in the biosynthesis of nanoparticles is a fast-growing technique and has gained much interest from researchers over the years.Aim: This study reported the utilisation of leaf extracts of Cannabis sativa L. (hemp) for the biosynthesis of silver nanoparticles (AgNPs).Methods: In this study, techniques such as transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) microanalysis and Fourier transform infrared (FT-IR) were carried out for the synthesis and characterisation of nanoparticles. The antibacterial efficacy of the synthesised nanoparticles was evaluated by using the agar diffusion and macrobroth dilution methods. The antibacterial properties of the biosynthesised AgNPs were evaluated against both Gram-negative and Gram-positive bacteria.Results: The formation of AgNPs was confirmed by colour change in plant extracts and further characterised by Ultraviolet-visible (UV-Vis) spectrophotometry TEM, SEM, EDX and FT-IR analyses. Fourier transform infrared analysis revealed the efficient capping and stabilisation properties of these particles and the nature of the capping agent. Silver nanoparticles prepared from leaf extracts showed effective antibacterial activity against Escherichia coli.Conclusion: Biosynthesised AgNPs showed a broad-spectrum antimicrobial susceptibility range and therefore represent promising antimicrobial agents. This is the first reported study for hemp leaf extracts and contributes to the environmentally friendly and cost-effective technique of biosynthesising nanoparticles for drug development.Contribution: This study contributes to the current medicinal properties of cannabis. Furthermore, it reflects that cannabis can also be utilized at a nanoscale with effective antibacterial efficacy.
      PubDate: 2022-10-27
      DOI: 10.4102/jomped.v6i1.160
      Issue No: Vol. 6, No. 1 (2022)
  • Gibberellic acid influences growth indices and biochemical parameters in
           micropropagated Ocimum gratissimum L. explants

    • Authors: Muyibat M. Olaitan, George Mangse, Chukwuma C. Ogbaga, Taofik O. Uthman
      First page: 7
      Abstract: Background: Ocimum gratissimum L. is a well-known tropical and subtropical plant widely utilised for both medicinal and nutritional purposes. However, its continuous existence is currently threatened because of excessive human exploitation and non-regulated collection.Aim: This study aimed at mass-producing O. gratissimum through its explants cultured on Murashige and Skoog (MS) medium.Settings: Sterile explants of O. gratissimum were used to generate whole plant through the process of somatic embryogenesis and under the influence of different plant growth regulators (PGRs).Methods: The growth medium was supplemented with various concentrations (0.1 mg/L, 0.5 mg/L and 1.0 mg/L) of PGRs, namely, gibberellic acid (GA3) and benzyl aminopurine (BAP) in combination with 0.2 mg/L indole acetic acid (IAA), which also served as the control.Results: The results showed that germination response, shoot and root lengths were significantly enhanced in O. gratissimum explants raised in media containing the two PGRs in a concentration-dependent manner after four weeks of culture. Ocimum gratissimum explants treated with GA3 and BAP also experienced reduced lipid peroxidation and ascorbic acid concentration, particularly at the highest tested concentration (1.0 mg/L) as evidenced by the significant drop in malondialdehyde (MDA) concentration. In response to this, the activities of superoxide dismutase (SOD) and catalase (CAT) were significantly increased in O. gratissimum explants raised in MS medium supplemented with PGRs.Conclusion: These results generally suggest that GA3 in combination with IAA is more favourable than BAP for the micropropagation of O. gratissimum explants. Thus, our study revealed that PGRs possess special attributes, which could be exploited in tissue culture for the micropropagation of O. gratissimum explants.
      PubDate: 2022-07-26
      DOI: 10.4102/jomped.v6i1.154
      Issue No: Vol. 6, No. 1 (2022)
  • Green tea (Camellia sinensis) aqueous extract improved human spermatozoa
           functions in vitro

    • Authors: Mmaphulane A. Setumo, Solomon SR Choma, Ralf Henkel, Chinyerum S. Opuwari
      First page: 8
      Abstract: Background: Idiopathic causes of infertility is associated with oxidative stress. Antioxidants are known to scavenge the excessive production of reactive oxygen species (ROS). Green tea (Camellia sinensis) contains polyphenols that enhance its antioxidant potential.Aim: This study focused on the impact of aqueous green tea extract on normozoospermic human spermatozoa.Setting: Department of Medical Biosciences, University of the Western Cape (UWC), South Africa.Methods: Semen samples obtained using masturbation method following three to five days of sexual abstinence from consenting men (n = 59) at the University of the Western Cape (UWC) were liquefied and analysed. Normozoospermic samples were selected according to the World Health Organization (WHO) 5th guideline. Thereafter, semen samples (7.5 × 106 /mL) were washed in human tubular fluid (HTF; 10 min at 300 ×g) and exposed to aqueous extracts of green tea (0 μg/mL, 0.4 μg/mL, 4 μg/mL, 40 μg/mL, 405 μg/mL) for 1 h with various sperm parameters analyzed. Human tubular fluid supplemented with bovine serum albumin (HTF-BSA; 10%) served as control.Results: Sperm motility, reactive oxygen species production, across some reaction and deoxyribonucleic acid (DNA) fragmentation decreased significantly, particularly at the highest concentration (405 μg/mL; p < 0.001). A substantial increase in the percentage of viable spermatozoa and those with intact mitochondrial membrane potential (MMP) were observed (p < 0.001).Conclusion: Aqueous extract of green tea prolonged sperm viability and MMP while reducing sperm intracellular ROS production, capacitation and across some reaction and DNA fragmentation, and may be attributed to its antioxidant potential. However, a high concentration of the extract appears to be detrimental to the functioning of human spermatozoa.
      PubDate: 2022-10-26
      DOI: 10.4102/jomped.v6i1.166
      Issue No: Vol. 6, No. 1 (2022)
  • A review of the role of the Cucurbitaceae family in food security in West

    • Authors: Olufunke O. Fajinmi, Olaoluwa O. Olarewaju, Georgina D. Arthur, Kuben Naidoo, Roger M. Coopoosamy
      First page: 8
      Abstract: Background: Food and nutritional security are main development goals in several countries of Africa. In West Africa, the use of African indigenous vegetables caters for the food and nutritional needs of a high proportion of the people, most particularly amongst the poor and rural dwellers. The family Cucurbitaceae is one of the most important and widely grown vegetables in the tropical and subtropical climates.Aim and objective: This review discusses the culinary relevance of several species of Cucurbitaceae and their roles in food security in West Africa.Methods: A literature search was conducted on electronic databases such as Google Books, Google Scholar, Scopus and Web of Science.Discussions: Certain genera such as Telfairia, Cucurbita and Citrullus and other Egusi species are commonly cultivated in different parts of West Africa including Nigeria for their fruits, seeds and leaves because of their crucial nutrient compositions and palatability in local diets. These species and other species of Cucurbitaceae are used as traditional vegetables or African indigenous vegetables and are either sourced from the wild or cultivated in several African countries. Some of these species have played roles beyond food security but have also been crucial tools for nutritional security, especially within the low-income group and rural communities.Conclusions: Several communities in West Africa use almost all parts of the plant (leaves, fruit, seed, flowers) of some species of this family as food or in food preparations. Their use could also lead to innovative pathways towards reducing diseases associated with malnutrition especially those related to protein deficiency.
      PubDate: 2022-06-28
      DOI: 10.4102/jomped.v6i1.155
      Issue No: Vol. 6, No. 1 (2022)
  • Cucurbitaceae species used as traditional medicine in West Africa

    • Authors: Olufunke O. Fajinmi, Olaoluwa O. Olarewaju, Georgina D. Arthur, Kuben Naidoo, Roger Coopoosamy
      First page: 9
      Abstract: Background: The use of some Cucurbitaceae species for the treatment of diseases is an ancient practice in traditional medicine systems in Africa and the cucurbitacins among others have been reported to be responsible for most of these healing activities.Aim: This review discusses the relevance of Cucurbitaceae species in traditional medicine in some west African countries.Methods: A literature search was conducted on electronic databases such as Google Books, Google Scholar, Scopus and Web of Science. The search involved the use of several terms and free text words which include ‘Cucurbitaceae species in West Africa traditional medicine’; ‘medicinal plants of the Cucurbitaceae family used to treat diseases in west African communities’.Results: Several Cucurbitaceae species are used in the region either in similar ways or different ways for the treatment of different diseases. The leaves are the most utilised plant parts and decoctions are the most common method of preparation. From this study, 18 species of Cucurbitaceae used for medicinal purposes were reviewed from Nigeria; 4 from Benin, Ghana, Côte d’Ivoire and Mali, respectively; 1 from Togo; 5 from Senegal; 9 from Cameroon and 3 from Gabon and Burkina Faso, respectively. Momordica charantia and Momordica balsamina are often utilised for abortion in some west African countries. Momordica species and Lagenaria breviflora are utilised to treat diabetes, cough related to respiratory infections and viral infections such as measles and chickenpoxConclusions: In-depth research into these plants could help to develop a natural, novel cure for diabetes and coronavirus (COVID-19) and effective, cheap contraceptive.Contribution: This review highlights the significant role of Cucurbitaceae species in the treatment of a wide range of diseases and health issues in the WestAfrican traditional medicine system. The information provided could be used as a guide by research scientists for the formulation of natural products to cure a variety of diseases.
      PubDate: 2022-11-29
      DOI: 10.4102/jomped.v6i1.163
      Issue No: Vol. 6, No. 1 (2022)
  • South African medicinal plants screened against Pseudomonas aeruginosa

    • Authors: McMaster Vambe, Roger M. Coopoosamy, Kuben Naidoo, Georgina D. Arthur
      First page: 10
      Abstract: Background: Pseudomonas aeruginosa is amongst the three high-ranking pathogens on the World Health Organization’s global priority list of antibiotic-resistant bacteria. The list highlights research priorities in drug discovery and development.Aim: This study aimed to provide a detailed account of efforts by researchers to find anti-P. aeruginosa compounds from South African medicinal plant species during the period 2000–2020.Method: Various online research and journal databases were used to obtain information relating to South African medicinal plants and P. aeruginosa.Results: During the study period (2000–2020), only 31 studies reported on the antibacterial properties of South African medicinal plants against the pathogen. Given that P. aeruginosa is a serious cause of morbidity and mortality worldwide, it was interesting to note that none of the published reports were dedicated solely to the pathogen. Furthermore, only one study included the antibiotic-resistant mutants of the pathogen as a test organism. Over 150 plant species belonging to 78 families were screened against the bacterium. Barringtonia racemosa, Croton megalobotrys, Erythrina caffra, Leucosidea sericea, Maesa lanceolata, Morella serrata and Trichilia emetica exhibited potent anti-P. aeruginosa properties (minimum inhibitory concentration [MIC] ˂ 0.1 mg/mL). Plumbagin, a compound isolated from the leaves of Aristea ecklonii demonstrated promising activities (MIC = 0.008 mg/mL) against the bacterium. Essential oils extracted from some plants demonstrated noteworthy antibacterial synergistic effects (fractional inhibitory concentration index [FICI] ˂ 0.5) when used in pairwise combinations with conventional antibiotics.Conclusion: Overall, empirical evidence presented in the scantly available literature suggests that novel anti-P. aeruginosa agents could be developed from South African herbal extracts.
      PubDate: 2022-09-28
      DOI: 10.4102/jomped.v6i1.153
      Issue No: Vol. 6, No. 1 (2022)
  • Sociocultural relevance of the bottle gourd and selected species of
           Cucurbitaceae family in West Africa

    • Authors: Olufunke O. Fajinmi, Olaoluwa O. Olarewaju, Georgina D. Arthur, Roger M. Coopoosamy, Kuben Naidoo
      First page: 10
      Abstract: Background: Since time immemorial, humans have devised means to improvise for survival on the planet earth. The environment has been the source of materials for manufacturing objects that have supported human existence. These materials include plants (plant parts and by-products) such as the Cucurbitaceae species.Aim: To discuss bottle gourd and some selected species of Cucurbitaceae in relation to the history, sociocultural and spiritual lives of the West African people.Methodology: A literature search was conducted on electronic databases such as Google Scholar, Google Books, Scopus, and Web of Science. The search was performed using several terms and free text words, combining them in an appropriate manner. The authors further set inclusion and exclusion criteria to screen for relevant articles.Results and discussion: Plants play crucial roles in the global economic, social, cultural, and spiritual stability. Several plant families have especially played a fundamental role(s) in the spiritual and cultural ceremonies, and history of many tribes and communities in Africa. This is because entertainment tools such as rattles, drums, harps, and lutes used during most of these ceremonies are often by-products of plants. This study revealed that Cucurbitaceae family is a spectacular class of plants with such roles. Traditional musical instruments derived from bottle gourd, Telfairia occidentalis and Momordica charantia, form an integral part of the history, spiritual and sociocultural life of some West African communities.Conclusion: The history of some tribes in West Africa is linked to specific Cucurbitaceae species.
      PubDate: 2022-07-22
      DOI: 10.4102/jomped.v6i1.139
      Issue No: Vol. 6, No. 1 (2022)
  • Phytochemical composition and chemical profiling of extracts of Cordia
           grandicalyx Oberm

    • Authors: Mildred A. Chauke, Motetelo A. Mogale, Ladislaus K. Mdee, Leshweni J. Shai
      First page: 11
      Abstract: Background: The search for bioactive organic products for the treatment of various diseases is a growing concern worldwide, because these bioactive natural products are associated with fewer side effects and are easily accessible.Aim: The present study analysed the phytochemical constituents and cytotoxic effects of the leaf, bark and fruit extracts of Cordia grandicalyx Oberm.Setting: Plant samples were collected from Ga-Mashishimale village in Ba-Phalaborwa Municipality, South Africa.Methods: Antioxidant activity was determined through 1,1-diphenyl-2-picrylhydrazyl radical scavenging method, whilst cytotoxic assay was assessed using the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide method. Plant extracts were subjected to phytochemical profiling using both qualitative and quantitative methods. The extracts were also subjected to fractionation using column chromatography and thin-layer chromatography, and the sub-fractions with considerable yields were identified using nuclear magnetic resonance (NMR).Results: The aqueous extracts of the bark and leaves had significant (p < 0.001) antioxidant activity as compared to negative controls and ascorbic acid. Additionally, appreciable amounts of total phenolic and alkaloid contents were recorded on polar extracts, notably 200 mg/GAE and 140 mg/quercetin equivalents for leaf cold water and leaf hot water extracts, respectively. All extracts were not toxic to cells, whilst the positive control (H2O2) led to almost 100% demise of cells. Two compounds were isolated from the leaf acetone extracts collected from fraction 20 to 30 and fraction 101 to 120 and identified as α˗amyrin and β-amyrin by NMR spectral analysis.Conclusion: The study provided evidence supporting the screening of plants for the discovery of therapeutic compounds. The study also revealed that all the different C. grandicalyx extracts were less toxic to cells and may provide scientific backing for continued use of the plant in mixtures for the treatment of diseases.
      PubDate: 2022-06-24
      DOI: 10.4102/jomped.v6i1.149
      Issue No: Vol. 6, No. 1 (2022)
  • A review of the medicinal plants with immune-boosting potential

    • Authors: Olaoluwa O. Olarewaju, Olufunke O. Fajinmi, Kuben K. Naidoo, Georgina D. Arthur, Roger M. Coopoosamy
      First page: 15
      Abstract: Background: Humanity is faced with various kinds of infections (viral, bacterial and fungal). The recent spread of coronavirus disease 2019 (COVID-19) has led the World Health Organization to declare the coronavirus disease outbreak as a global pandemic. Medical experts suggested that people with high immunity tend to survive the infection more than those with low immunity. Hence, people must boost their immunity by consuming more fruit and vegetable or medications with immune-boosting potential to survive any form of unforeseen infections.Aim: This study aimed to review horticultural fruit, vegetables and medicinal plants with immune-boosting potentials that may be useful in drug formulations to combat infectious diseases.Methods: A literature search was conducted on electronic databases such as Google Scholar, Scopus and Web of Science. Several terms and free text words were combined in an appropriate manner to perform the search. Identified articles were reviewed independently for eligibility and extract of information.Results: The study highlighted medicinal and horticultural crops with the potential to combat the symptoms of Covid-19 such as cold, cough, chest pain and high fever. Details about how despite effective vaccines, respiratory infections such as asthma, tuberculosis, pneumonia and measles are causing significant death worldwide.Conclusion: This review highlights the fact that pharmaceutical companies should be encouraged to maximise the use of medicinal plants suggested for drug formulation strategies and humans should consume more fruit and vegetables to boost their immune systems.Contribution: The use of natural products is now receiving global attention against synthetic ones to combat infections and the recent COVID-19 outbreak has called for innovative methods of treating the disease and its symptoms. This review provided information about medicinal plants with immune-boosting potential that when consumed or used in drug formulations can boost immune systems against various forms of infections. Insights on how the burden of diseases can be reduced and healthy lifestyles enhanced naturally are provided for social and economic developments.
      PubDate: 2022-10-07
      DOI: 10.4102/jomped.v6i1.158
      Issue No: Vol. 6, No. 1 (2022)
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