 Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
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- Development of caspase-3-selective activity-based probes for PET imaging
of apoptosis
Authors: Louis Lauwerys; Lucas Beroske, Angelo Solania, Christel Vangestel, Alan Miranda, Nele Van Giel, Karuna Adhikari, Anne-Marie Lambeir, Leonie wyffels, Dennis Wolan, Pieter Van der Veken Filipe Elvas
Abstract: The cysteine-aspartic acid protease caspase-3 is recognized as the main executioner of apoptosis in cells responding to specific extrinsic and intrinsic stimuli. Caspase-3 represents an interesting biomarker t...
PubDate: 2024-08-08T00:00:00Z
- Cyclotron production of manganese-52: a promising avenue for multimodal
PET/MRI imaging
Authors: Francesca Porto; Sara Cisternino, Emiliano Cazzola, Giorgia Speltri, Liliana Mou, Alessandra Boschi, Lorenza Marvelli, Giovanni Di Domenico, Antonella Pagnoni, Lucia De Dominicis, Irene Calliari, Claudio Gennari, Licia Uccelli, Gaia Pupillo, Giancarlo Gorgoni, Juan Esposito…
Abstract: The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven prod...
PubDate: 2024-08-02T00:00:00Z
- The development of 177Lu-DOTA-CC-PSMA following a unified “Click
Chemistry” protocol of synthesizing metal nuclide-conjugated
radiopharmaceuticals
Authors: Xiaobei Zheng; Shuai Xue, Zhongqi Zhao, Shuxin Jin, Shuhua He, Lina Jia, Zheng Li, Christian Vanhove, Filip De Vos, Zijun Kuang, Tiantian Wang, Sara Neyt, Lan Zhang Xiao Li
Abstract: Currently, the synthesis pathway of metal nuclide-labeled radiopharmaceuticals is mainly divided into two steps: first, connecting the chelator with the target molecule, and second, labeling the metal nuclide ...
PubDate: 2024-07-31T00:00:00Z
- In vitro and in vivo analyses of eFAP: a novel FAP-targeting small
molecule for radionuclide theranostics and other oncological interventions
Authors: Circe D. van der Heide; Hanyue Ma, Mark W.H. Hoorens, Joana D. Campeiro, Debra C. Stuurman, Corrina M.A. de Ridder, Yann Seimbille Simone U. Dalm
Abstract: Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed by cancer-associated fibroblasts in the tumor stroma, is an interesting biomarker for targeted radionuclide theranostics. FAP-...
PubDate: 2024-07-29T00:00:00Z
- Generic semi-automated radiofluorination strategy for single domain
antibodies: [18F]FB-labelled single domain antibodies for PET imaging of
fibroblast activation protein-α or folate receptor-α overexpression in
cancer
Authors: Herlinde Dierick; Laurent Navarro, Hannelore Ceuppens, Thomas Ertveldt, Ana Rita Pombo Antunes, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot, Matthias D’Huyvetter, Tony Lahoutte, Vicky Caveliers Jessica Bridoux
Abstract: Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the...
PubDate: 2024-07-24T00:00:00Z
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