Authors:Louis Lauwerys; Lucas Beroske, Angelo Solania, Christel Vangestel, Alan Miranda, Nele Van Giel, Karuna Adhikari, Anne-Marie Lambeir, Leonie wyffels, Dennis Wolan, Pieter Van der Veken Filipe Elvas Abstract: The cysteine-aspartic acid protease caspase-3 is recognized as the main executioner of apoptosis in cells responding to specific extrinsic and intrinsic stimuli. Caspase-3 represents an interesting biomarker t... PubDate: 2024-08-08T00:00:00Z
Authors:Xiaobei Zheng; Shuai Xue, Zhongqi Zhao, Shuxin Jin, Shuhua He, Lina Jia, Zheng Li, Christian Vanhove, Filip De Vos, Zijun Kuang, Tiantian Wang, Sara Neyt, Lan Zhang Xiao Li Abstract: Currently, the synthesis pathway of metal nuclide-labeled radiopharmaceuticals is mainly divided into two steps: first, connecting the chelator with the target molecule, and second, labeling the metal nuclide ... PubDate: 2024-07-31T00:00:00Z
Authors:Circe D. van der Heide; Hanyue Ma, Mark W.H. Hoorens, Joana D. Campeiro, Debra C. Stuurman, Corrina M.A. de Ridder, Yann Seimbille Simone U. Dalm Abstract: Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed by cancer-associated fibroblasts in the tumor stroma, is an interesting biomarker for targeted radionuclide theranostics. FAP-... PubDate: 2024-07-29T00:00:00Z
Authors:Herlinde Dierick; Laurent Navarro, Hannelore Ceuppens, Thomas Ertveldt, Ana Rita Pombo Antunes, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot, Matthias D’Huyvetter, Tony Lahoutte, Vicky Caveliers Jessica Bridoux Abstract: Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the... PubDate: 2024-07-24T00:00:00Z
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