Authors:Yumeng Zhang; Zhouming Zhao, Kai Wang, Kangjie Lyu, Cai Yao, Lin Li, Xia Shen, Tengfei Liu, Xiaodi Guo, Haiyan Li, Wenshou Wang Tsai-Ta Lai Abstract: To study structure-specific solubilization effect of Sulfobutyl ether-β-cyclodextrin (SBE-β-CD) on Remdesivir (RDV) and to understand the experimental clathration with the aid of quantum mechanics (QM), molecu... PubDate: 2022-04-25T00:00:00Z
Authors:Svend Poulsen; Louise Jørgensen Pia Søndergaard Galle Abstract: Anti-drug antibodies (ADAs) can interfere with ligand binding assays (LBAs) by binding to epitopes recognized by the assay antibodies or by preventing assay antibody binding through steric hindrance. This can ... PubDate: 2022-04-11T00:00:00Z
Authors:Xiaofeng Wang; Khurram Jamil Abstract: The objective of this population pharmacokinetics (PK) analysis was to characterize the PK of terlipressin and its active metabolite, lysine-vasopressin (L-VP), in patients with hepatorenal syndrome (HRS), fol... PubDate: 2022-04-04T00:00:00Z
Authors:Iyad Rashid; Rula Raji Haddadin, Ashaar Abdulsalam Alkafaween, Rawan Nayef Alkaraki Rehan Mohammad Alkasasbeh Abstract: The aim of this study was to investigate powder mechanics upon compression using data obtained from force-displacement (F-D) curves. The Kawakita model of powder compression analysis was adopted in order to co... PubDate: 2022-03-28T00:00:00Z
Authors:Wei Chen; Siegfried Stolz, Vincent Wegbecher, Dixy Parakkattel, Christina Haeuser, Nuria Sancho Oltra, Ravuri S. K. Kishore, Steven Bond, Christian Bell Robert Kopf Abstract: Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of aggregates an... PubDate: 2022-03-21T00:00:00Z
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