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- Mechanical network motifs as targets for mechanomedicine
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Abstract: Publication date: Available online 23 August 2024Source: Drug Discovery TodayAuthor(s): Mengnan Lu, Zhao Xu, Feng Xu, Chunyan Yin, Hui Guo, Bo Cheng
- Hit me with your best shot: Integrated hit discovery for the next
generation of drug targets-
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Abstract: Publication date: Available online 22 August 2024Source: Drug Discovery TodayAuthor(s): S. Neha Ashraf, J. Henry Blackwell, Geoffrey A. Holdgate, Simon C. C. Lucas, Alisa Solovyeva, R. Ian Storer, Benjamin C. Whitehurst
- Chemical coverage of human biological pathways
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Abstract: Publication date: Available online 22 August 2024Source: Drug Discovery TodayAuthor(s): Haejin Angela Kwak, Lihua Liu, Claudia Tredup, Sandra Röhm, Panagiotis Prinos, Jark Böttcher, Matthieu Schapira
- Designed dualsteric modulators: A novel route for drug discovery
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Abstract: Publication date: Available online 19 August 2024Source: Drug Discovery TodayAuthor(s): Nuan Li, Guodong Zheng, Lili Fu, Ning Liu, Ting Chen, Shaoyong Lu
- Exploration of inhibitors targeting KIF18A with ploidy-specific lethality
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Abstract: Publication date: Available online 19 August 2024Source: Drug Discovery TodayAuthor(s): Qingsong Chen, Xiangyang Le, Qianbin Li, Suyou Liu, Zhuo Chen
- Preclinical alternative drug discovery programs for monogenic rare
diseases. The case of hereditary spastic paraplegias-
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Abstract: Publication date: Available online 19 August 2024Source: Drug Discovery TodayAuthor(s): Matteo Rossi Sebastiano, Shinji Hadano, Fabrizia Cesca, IAHSP Consortium, Giuseppe Ermondi
- Machine learning and natural language processing in clinical trial
eligibility criteria parsing: a scoping review-
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Abstract: Publication date: Available online 19 August 2024Source: Drug Discovery TodayAuthor(s): Klaudia Kantor, Mikołaj Morzy
- Role of long noncoding RNAs in the regulation of alternative splicing in
glioblastoma-
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Abstract: Publication date: Available online 19 August 2024Source: Drug Discovery TodayAuthor(s): Bhupender Yadav, Pooja Yadav, Sunita Yadav, Amit Kumar Pandey
- Are protein–ligand docking programs good enough to predict experimental
poses of noncovalent ligands bound to the SARS-CoV-2 main protease'-
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Abstract: Publication date: Available online 14 August 2024Source: Drug Discovery TodayAuthor(s): Ariadna Llop-Peiró, Guillem Macip, Santiago Garcia-Vallvé, Gerard Pujadas
- Promoting the social implementation of digital and mobile health: effects
of regulation on user and non-user behavior in East Asia-
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Abstract: Publication date: Available online 6 August 2024Source: Drug Discovery TodayAuthor(s): Hanlin Feng, Makoto Niwa, Jianfei Cao, Karin Kurata, Shuo Zhang, Yenogjoo Lim, Tack Joong Kim, Xitong Guo, Itsuki Kageyama, Kota Kodama
- Comparative analysis of FDA approvals by top 20 pharma companies
(2014–2023)-
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Abstract: Publication date: Available online 5 August 2024Source: Drug Discovery TodayAuthor(s): Alexander Schuhmacher, Oliver Gassmann, Markus Hinder, Dominik Hartl
- The efficacy and safety of eculizumab in patients and the role of C5
polymorphisms-
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Abstract: Publication date: Available online 5 August 2024Source: Drug Discovery TodayAuthor(s): Hendrikus Bernhard Bouwman, Henk-Jan Guchelaar
- Oxygen-generating biomaterials for cardiovascular engineering: unveiling
future discoveries-
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Abstract: Publication date: Available online 3 August 2024Source: Drug Discovery TodayAuthor(s): Masoud Mozafari, Mohammad E Barbati
- Repurposing cardiac glycosides for anticancer treatment: a review of
clinical studies-
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Abstract: Publication date: Available online 3 August 2024Source: Drug Discovery TodayAuthor(s): Wan Najbah Nik Nabil, Rongchen Dai, Mengfan Liu, Zhichao Xi, Hongxi Xu
- Advances in structure-based drug design targeting membrane protein markers
in prostate cancer-
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Abstract: Publication date: Available online 3 August 2024Source: Drug Discovery TodayAuthor(s): J.P. Batista-Silva, D. Gomes, S.F. Sousa, Ângela Sousa, L.A. Passarinha
- Navigating the frontier of drug-like chemical space with cutting-edge
generative AI models-
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Abstract: Publication date: Available online 3 August 2024Source: Drug Discovery TodayAuthor(s): Antonio Lavecchia
- Multidisciplinary considerations for implementing Bayesian borrowing in
basket trials-
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Abstract: Publication date: Available online 2 August 2024Source: Drug Discovery TodayAuthor(s): Kristine R. Broglio, Jenny E. Blau, Elizabeth A. Pilling, James M. S. Wason
- An overview of the development of pharmacotherapeutics targeting
SARS-CoV-2-
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Abstract: Publication date: Available online 2 August 2024Source: Drug Discovery TodayAuthor(s): Tom Lucaj, Ian Hay, Amirreza Samarbakhsh, Mel Bedi, Arun K. Iyer, Navnath S. Gavande
- Deciphering immune responses: a comparative analysis of influenza
vaccination platforms-
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Abstract: Publication date: Available online 2 August 2024Source: Drug Discovery TodayAuthor(s): Charles H. Jones, Teresa Hauguel, Marie Beitelshees, Michelle Davitt, Verna Welch, Kelly Lindert, Pirada Allen, Jane M. True, Mikael Dolsten
- Targeting cancer using scaffold-hopping approaches: illuminating SAR to
improve drug design-
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Abstract: Publication date: Available online 26 July 2024Source: Drug Discovery TodayAuthor(s): Shivani, T.A. Abdul Rahaman, Sandeep Chaudhary
- New developments in celiac disease treatments
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Abstract: Publication date: Available online 25 July 2024Source: Drug Discovery TodayAuthor(s): Franziska Buriánek, Christian Gege, Petar Marinković
- Three-dimensional cell culture: Future scope in cancer vaccine development
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Abstract: Publication date: Available online 25 July 2024Source: Drug Discovery TodayAuthor(s): Mahfoozur Rahman, Ankit Sahoo, Waleed H Almalki, Salem Salman Almujri, Alhussain Aodah, Abdulrahman A. Alnofei, Abdulrahman Alhamyani
- Rewriting the textbook for pharma: how to adapt and thrive in a digital,
personalized and collaborative world-
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Abstract: Publication date: Available online 23 July 2024Source: Drug Discovery TodayAuthor(s): Charles H. Jones, Subha Madhavan, Kannan Natarajan, Michael Corbo, Jane True, Mikael Dolsten
- Synergizing blockchain and artificial intelligence to enhance healthcare
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Abstract: Publication date: Available online 19 July 2024Source: Drug Discovery TodayAuthor(s): Hossein Omidian
- P-glycoprotein inhibitors as an adjunct therapy for TB
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Abstract: Publication date: Available online 19 July 2024Source: Drug Discovery TodayAuthor(s): Kishan Kumar Parida, Monali Lahiri, Mainak Ghosh, Aman Dalal, Nitin Pal Kalia
- Navigating the future of health care with AI-driven digital therapeutics
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Abstract: Publication date: Available online 19 July 2024Source: Drug Discovery TodayAuthor(s): Nupur Vasdev, Tanisha Gupta, Bhakti Pawar, Anoothi Bain, Rakesh Kumar Tekade
- Ionic liquid-based formulation approaches for enhanced transmucosal drug
delivery-
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Abstract: Publication date: Available online 19 July 2024Source: Drug Discovery TodayAuthor(s): Omar Khan, Rohit Bhawale, Ravindra Vasave, Neelesh Kumar Mehra
- Phytochemicals in antiviral drug development against human respiratory
viruses-
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Abstract: Publication date: Available online 18 July 2024Source: Drug Discovery TodayAuthor(s): Surya Kant Mehta, Ran Bahadur Pradhan
- Clinical trial evidence supporting FDA approval of novel orphan drugs
between 2017 and 2023-
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Abstract: Publication date: Available online 18 July 2024Source: Drug Discovery TodayAuthor(s): Qi Chen, Yang Xu, Ruoxuan Qu, Xingxian Luo, Yue Yang
- Caught between a ROCK and a hard place: current challenges in
structure-based drug design-
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Abstract: Publication date: Available online 17 July 2024Source: Drug Discovery TodayAuthor(s): Daniele Pala, David E. Clark
- Neurological insights into brain-targeted cancer therapy and bioinspired
microrobots-
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Abstract: Publication date: Available online 17 July 2024Source: Drug Discovery TodayAuthor(s): Shampa Ghosh, Rakesh Bhaskar, Richa Mishra, M. Arockia Babu, Mosleh Mohammad Abomughaid, Niraj Kumar Jha, Jitendra Kumar Sinha
- Innovative Strategies in Cancer Treatment: Harnessing Cuproptosis and
Nanotechnology for Targeted Therapy-
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Abstract: Publication date: Available online 17 July 2024Source: Drug Discovery TodayAuthor(s): Tenzin Tsering Dongsar, Tenzin Sonam Dongsar, Garima Gupta, Prashant Kesharwani
- Advancements in manganese complex-based MRI agents: Innovations, design
strategies, and future directions-
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Abstract: Publication date: Available online 15 July 2024Source: Drug Discovery TodayAuthor(s): Shubham Roy, Jingsi Gu, Wujiong Xia, Chao Mi, Bing Guo
- Metallocompounds as anticancer agents against osteosarcoma
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Abstract: Publication date: Available online 15 July 2024Source: Drug Discovery TodayAuthor(s): Lucía Santa Maria de la Parra, Lucía M Balsa, Ignacio E León
- Developing public–private R&D consortia to accelerate Alzheimer’s
disease drug development-
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Abstract: Publication date: Available online 15 July 2024Source: Drug Discovery TodayAuthor(s): Joel West, Paul Olk
- Targeting histone deacetylases: Emerging applications beyond cancer
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Abstract: Publication date: Available online 10 July 2024Source: Drug Discovery TodayAuthor(s): Yasir S. Raouf
- Therapies for Inherited Retinal Dystrophies: What is Enough'
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Abstract: Publication date: Available online 9 July 2024Source: Drug Discovery TodayAuthor(s): Bart P. Leroy, Avril Daly, Elise Héon, José-Alain Sahel, Hélène Dollfus, The IRD Study Group
- Reliable business case for repurposing of existing medicines requires key
changes in government policies-
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Abstract: Publication date: Available online 9 July 2024Source: Drug Discovery TodayAuthor(s): Samuel J. de Visser, Sibren van den Berg, Arend Mosterd, Donald C. Lo
- On the pivotal role of drug discovery in sustainable EU pharma reform
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Abstract: Publication date: Available online 9 July 2024Source: Drug Discovery TodayAuthor(s): Bart De Spiegeleer, Benoit Deprez, Eelko Hak, Michal Markuszewski, Evelien Wynendaele
- Aging and cognitive resilience: Molecular mechanisms as new potential
therapeutic targets-
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Abstract: Publication date: Available online 9 July 2024Source: Drug Discovery TodayAuthor(s): Ana Cordeiro, Catarina Gomes, Joana Bicker, Ana Fortuna
- Current understanding of the link between angiotensin-converting enzyme
and pain perception-
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Abstract: Publication date: Available online 6 July 2024Source: Drug Discovery TodayAuthor(s): Kiran D. Bhilare, Prakashkumar Dobariya, Filip Hanak, Patrick E. Rothwell, Swati S. More
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