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Abstract: Drug Development Research, Volume 83, Issue 7, Page 1467-1468, November 2022.
PubDate: 2022-11-23T10:12:57-08:00
DOI: 10.1002/ddr.21829
Issue No: Vol. 83, No. 7 (2022)
- Cover Image, Volume 83, Issue 7
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Authors:
Tong Zhang; Guo‐Yan Liu,
Jing‐Long Cao,
Yan‐Nan Li,
Hui Xue,
Hai‐Tao Wu,
Cheng‐Hao Jin
Abstract: Drug Development Research, Volume 83, Issue 7, Page i-i, November 2022.
PubDate: 2022-11-23T10:12:57-08:00
DOI: 10.1002/ddr.22018
Issue No: Vol. 83, No. 7 (2022)
- Multitargeted C9‐substituted ester and ether derivatives of berberrubine
for Alzheimer's disease: Design, synthesis, biological evaluation,
metabolic stability, and pharmacokinetics-
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Authors:
Rinky Raghuvanshi; Ashiya Jamwal,
Utpal Nandi,
Sandip B. Bharate
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-12-02T09:58:32-08:00
DOI: 10.1002/ddr.22017
- Ulinastatin ameliorates the malignant progression of prostate cancer cells
by blocking the RhoA/ROCK/NLRP3 pathway-
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Authors:
Zhiguang Liu; Xiaochun Zhu,
Chenglin Xu,
Feng Min,
Guofeng Yu,
Chuhong Chen
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-12-02T09:54:29-08:00
DOI: 10.1002/ddr.22010
- Expanding the therapeutic options for Candida infections using novel
inhibitors of secreted aspartyl proteases-
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Authors:
Shuvechha Chakraborty; Kshitija Rahate,
Chandan Kumar,
Susan Idicula‐Thomas
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-11-26T11:29:41-08:00
DOI: 10.1002/ddr.22015
- Discovery of pyrazole‐carbohydrazide with indole moiety as tubulin
polymerization inhibitors and anti‐tumor candidates-
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Authors:
Ruo‐Jun Man; Tian Lu,
Chi‐Chong Zheng,
Tong Li,
Meng‐Ke Wu,
Dong‐Dong Li,
Xue‐Mei He
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-11-25T11:55:32-08:00
DOI: 10.1002/ddr.22016
- Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel
strategy for the treatment of osteosarcoma and Ewing sarcoma-
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Authors:
Staci L. Haney; Dan Feng,
Yashpal S. Chhonker,
Michelle L. Varney,
Jacob T. Williams,
Lynette M. Smith,
James B. Ford,
Daryl J. Murry,
Sarah A. Holstein
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-11-25T11:49:13-08:00
DOI: 10.1002/ddr.22012
- Novel Vanillin‐based hybrids inhibit quorum sensing and silences
phenotypical expressions in Pseudomonas aeruginosa-
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Authors:
Tamanna Dua; Surabhi Mangal,
Goel Akshita,
Harshdeep,
Ankit K. Atri,
Purshotam Sharma,
Kusum Harjai,
Vasundhara Singh
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-11-23T11:04:21-08:00
DOI: 10.1002/ddr.22011
- Labdane conjugates protect cardiomyocytes from doxorubicin‐induced
cardiotoxicity-
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Authors:
Irene Cuadrado; Sandra Oramas‐Royo,
Laura González‐Cofrade,
Ángel Amesty,
Sonsoles Hortelano,
Ana Estévez‐Braun,
Beatriz Heras
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-11-19T09:53:58-08:00
DOI: 10.1002/ddr.22014
- Dioscin induces osteosarcoma cell apoptosis by upregulating
ROS‐mediated P38 MAPK signaling-
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Authors:
Gui‐zhou Zheng; Qi‐hao Zhang,
Bo Chang,
Peng Xie,
Hang Liao,
Shi‐xin Du,
Xue‐dong Li
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-11-19T09:50:03-08:00
DOI: 10.1002/ddr.22009
- In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine
derivatives: Design, synthesis, antioxidant, anti‐diabetic,
anti‐Alzheimer, and anti‐arthritic activities with molecular modeling
simulation-
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Authors:
Ashraf S. Hassan; Nesrin M. Morsy,
Wael M. Aboulthana,
Ahmed Ragab
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-11-15T10:05:49-08:00
DOI: 10.1002/ddr.22008
- A cytotoxic survey on 2‐amino‐1H‐imidazol based synthetic marine
sponge alkaloid analogues-
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Authors:
Nikolett Gémes; Zsófia Makra,
Patrícia Neuperger,
Enikő Szabó,
József Á. Balog,
Lili Borbála Flink,
Beáta Kari,
László Hackler,
László. G. Puskás,
Iván Kanizsai,
Gábor J. Szebeni
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-11-02T10:08:35-07:00
DOI: 10.1002/ddr.22006
- Neuroprotective effects of nerolidol against Alzheimer's disease in Wistar
rats-
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Authors:
Peyman Taheri; Parichehreh Yaghmaei,
Zahra Hajebrahimi,
Kazem Parivar
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-11-01T11:34:08-07:00
DOI: 10.1002/ddr.22002
- Conjugates of lactobionic acid and IR820: New photosensitizers for
efficient photodynamic therapy of hepatoma cells-
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Authors:
Xiaoyin Yuan; Yayu Tao,
Wen Xiao,
Kunda Du,
Hang Hu,
Defeng Xu,
Qingbo Xu
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-10-27T10:49:47-07:00
DOI: 10.1002/ddr.22007
- Circ_0002099 is a novel molecular therapeutic target for bladder cancer
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Authors:
Ping Fang; Qingling Jiang,
Sizhong Liu,
Jun Gu,
Kai Hu,
Zishu Wang
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-10-27T10:49:04-07:00
DOI: 10.1002/ddr.22005
- 1‐Sulfonylated 1,2,3,4‐tetrahydroquinoline‐6‐carboxylic acids as
simple, readily‐accessible MCL‐1 inhibitors-
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Authors:
Lijia Chen; Alexandria M. Chan,
Paul T. Wilder,
Steven Fletcher
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-10-24T09:26:13-07:00
DOI: 10.1002/ddr.22004
- The HSP90 inhibitor 17‐AAG induced calcium‐mediated apoptosis
in filarial parasites-
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Authors:
Faiyaz Ahmad; Shweta Sharma,
Smita Yadav,
Sushma Rathaur
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-10-11T09:04:26-07:00
DOI: 10.1002/ddr.22003
- SIRT1/Notch1 signal axis involves in the promoting effect of Segetalin B
on bone formation-
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Authors:
Xiaoyong Lan; Haiping Ma,
Qingfeng Cheng,
Yuhong Xiao,
Lingfeng Zou,
Zhen Yuan,
Jun Luo
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-10-07T10:49:11-07:00
DOI: 10.1002/ddr.22001
- Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and
modifies tumor microenvironment-
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Authors:
Yiyu Qin; Mingdi Zhang,
Haiming Lei,
Hongyan Wu,
Cheng Huang,
Xin Zhou,
Yang Fu,
Mingzhe Weng,
Mingzhe Ma
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-10-02T10:53:52-07:00
DOI: 10.1002/ddr.22000
- Ricolinostat suppresses proliferation, promotes apoptosis, and enhances
the antiproliferative activity of topoisomerase inhibitors in cervical
cancer cells-
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Authors:
Sumeet Kaur; Prerna Rajoria,
Madhu Chopra
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-29T11:33:58-07:00
DOI: 10.1002/ddr.21999
- Design, synthesis, and structure–activity relationship of
caffeine‐based triazoles as dual AChE and BACE‐1 inhibitors-
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Authors:
Mohit Sharma; Ankita Sharma,
Vijay K. Nuthakki,
Shipra Bhatt,
Utpal Nandi,
Sandip B. Bharate
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-26T11:54:05-07:00
DOI: 10.1002/ddr.21998
- Therapeutic potential and research progress of diosgenin for lipid
metabolism diseases-
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Authors:
Shi‐Zhao Zhang; Peng‐Peng Liang,
Ya‐Nan Feng,
Guo‐Liang Yin,
Feng‐Cui Sun,
Chao‐Qun Ma,
Feng‐Xia Zhang
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-20T11:59:19-07:00
DOI: 10.1002/ddr.21991
- Discovery of pyrazole‐1‐carboxamide derivatives as novel Gi‐biased
μ‐opioid receptor agonists-
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Authors:
Jae‐Hoon Jung; In Hee Jang,
Yeo Ok Kim,
Sunhong Kim,
Myung Ha Yoon,
Yong‐Chul Kim
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-20T02:34:06-07:00
DOI: 10.1002/ddr.21980
- Blood–brain barrier permeable benzylpiperidin‐4‐yl‐linked
benzylamino benzamides as dual cholinesterase inhibitors-
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Authors:
Razia Banoo; Vijay K. Nuthakki,
Mohd Abdullaha,
Mohit Sharma,
Sandip B. Bharate
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-16T11:19:53-07:00
DOI: 10.1002/ddr.21997
- Synthesis and evaluation of [177Lu]Lu‐labeled porphyrin loaded PAMAM
dendrimer: Impact on tumor uptake and pharmacokinetics-
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Naveen Kumar; Mohini Guleria,
Avik Chakraborty,
Jeyachitra Amirdhanayagam,
Trupti Upadhye Bannore,
Archana Damle,
Haladhar D. Sarma,
Tapas Das
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-16T11:13:47-07:00
DOI: 10.1002/ddr.21996
- Berberine ameliorates pulmonary inflammation in mice with influenza viral
pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin
D‐mediated pyroptosis-
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Authors:
Chen An; Yanmin Wu,
Jun Wu,
Huanwei Liu,
Siyao Zhou,
Dongyu Ge,
Ruijuan Dong,
Leiming You,
Yu Hao
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-16T11:03:14-07:00
DOI: 10.1002/ddr.21995
- α‐Pinene inhibits the growth of cervical cancer cells through its
proapoptotic activity by regulating the miR‐34a‐5p/Bcl‐2 signaling
axis-
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Authors:
Xiaosu Huang; Pei Yan,
Wenqing Ding,
Chang Zhou,
Qiuxiang Xu,
Ming Li,
Lianbao Ye,
Weiqiang Chen
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-08T10:24:20-07:00
DOI: 10.1002/ddr.21994
- Acetamidobenzoxazolone scaffold as a promising translocator protein
(18 kDa, TSPO) marker for neuroinflammation imaging: Advancement in last
decennial period-
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Anupriya Adhikari; Ming‐Rong Zhang,
Anjani Kumar Tiwari
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-08T10:09:45-07:00
DOI: 10.1002/ddr.21989
- Nonacidic thiophene‐based derivatives as potential analgesic and design,
synthesis, biological evaluation, and metabolic stability study-
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Authors:
Demiana S. Mikhail; Hala B. El‐Nassan,
Sally T. Mahmoud,
Samar H. Fahim
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-08T10:09:32-07:00
DOI: 10.1002/ddr.21992
- Calycosin represses AIM2 inflammasome‐mediated inflammation and
pyroptosis to attenuate monosodium urate‐induced gouty arthritis through
NF‐κB and p62‐Keap1 pathways-
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Authors:
Jing Tian; Dapeng Zhou,
Liangbi Xiang,
Bing Xie,
Baichuan Wang,
Yang Li,
Xinwei Liu
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-07T04:04:32-07:00
DOI: 10.1002/ddr.21985
- The cytotoxicity of karanjin toward breast cancer cells is involved in the
PI3K/Akt signaling pathway-
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Authors:
Jinsong Yu; Han Yang,
Chunliu Lv,
Xiaowei Dai
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-06T12:39:27-07:00
DOI: 10.1002/ddr.21986
- Paeonol inhibits chronic constriction injury‐induced astrocytic
activation and neuroinflammation in rats via the HDAC/miR‐15a pathway-
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Longxue Cai; Renqing Zeng,
Qi Huang,
Xianfa Liu,
Zuohong Cao,
Qicai Guo
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-05T12:07:32-07:00
DOI: 10.1002/ddr.21993
- Solasonine alleviates high glucose‐induced podocyte injury through
increasing Nrf2‐medicated inhibition of NLRP3 activation-
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Authors:
Qianjin Zhang; Yichuan Hu,
Jin‐E Hu,
Min Zhang
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-01T11:00:10-07:00
DOI: 10.1002/ddr.21988
- Peimine‐induced apoptosis and inhibition of migration by regulating
reactive oxygen species‐mediated MAPK/STAT3/NF‐κB and
Wnt/β‐catenin signaling pathways in gastric cancer MKN‐45 cells-
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Tong Zhang; Guo‐Yan Liu,
Jing‐Long Cao,
Yan‐Nan Li,
Hui Xue,
Hai‐Tao Wu,
Cheng‐Hao Jin
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-09-01T10:53:48-07:00
DOI: 10.1002/ddr.21987
- Beta‐lactam resistance and the effectiveness of antimicrobial peptides
against KPC‐producing bacteria-
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Guilherme Costa de Souza; Cesar Augusto Roque‐Borda,
Fernando R. Pavan
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-08-30T10:33:42-07:00
DOI: 10.1002/ddr.21990
- Versatile use of Carmofur: A comprehensive review of its chemistry and
pharmacology-
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Mohammad Mohiminul Islam; Shama P. Mirza
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-08-28T10:39:20-07:00
DOI: 10.1002/ddr.21984
- Neratinib inhibits proliferation and promotes apoptosis of acute myeloid
leukemia cells by activating autophagy‐dependent ferroptosis-
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Authors:
Hongxia Ma; Yang Liu,
Zhen Miao,
Shijia Cheng,
Yunan Zhu,
Yifan Wu,
Xinxin Fan,
Jing Yang,
Xingang Li,
Liyin Guo
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-08-28T10:35:08-07:00
DOI: 10.1002/ddr.21983
- Celastrol: A lead compound that inhibits SARS‐CoV‐2 replication, the
activity of viral and human cysteine proteases, and virus‐induced IL‐6
secretion-
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Authors:
Carlos A. Fuzo; Ronaldo B. Martins,
Thais F. C. Fraga‐Silva,
Martin K. Amstalden,
Thais Canassa De Leo,
Juliano P. Souza,
Thais M. Lima,
Lucia H. Faccioli,
Débora Noma Okamoto,
Maria Aparecida Juliano,
Suzelei C. França,
Luiz Juliano,
Vania L. D. Bonato,
Eurico Arruda,
Marcelo Dias‐Baruffi
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-08-21T10:43:54-07:00
DOI: 10.1002/ddr.21982
- Palmatine attenuates hepatocyte injury by promoting autophagy via the
AMPK/mTOR pathway after alcoholic liver disease-
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Authors:
Guo‐Shuai Lin; Mao‐Mao Zhao,
Qi‐Chao Fu,
Shu‐Yi Zhao,
Tao‐Tao Ba,
Hong‐Xia Yu
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-08-17T06:53:54-07:00
DOI: 10.1002/ddr.21981
- A review on synthetic strategy, molecular pharmacology of indazole
derivatives, and their future perspective-
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Authors:
Suvadeep Mal; Udita Malik,
Monalisa Mahapatra,
Abhishek Mishra,
Dilipkumar Pal,
Sudhir K. Paidesetty
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-08-16T02:40:10-07:00
DOI: 10.1002/ddr.21979
- Knockdown of replication protein A 3 induces protective autophagy and
enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting
AKT/mTOR signaling via binding to cyclin‐dependent kinases regulatory
subunit 2-
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Authors:
Lijun Chen; Ke Hu,
Yu Liu,
Lingli Liu,
Juanjuan Tang,
Xiaobing Qin
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-07-28T10:19:13-07:00
DOI: 10.1002/ddr.21978
- Synthesis, biological evaluation, and in silico studies of
indole‐tethered pyrazoline derivatives as anticancer agents targeting
topoisomerase IIα-
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Authors:
Kashif Haider; Shivani Sharma,
Yuba Raj Pokharel,
Subham Das,
Alex Joseph,
Abul Kalam Najmi,
Faiz Ahmad,
Mohammad Shahar Yar
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-07-27T10:45:44-07:00
DOI: 10.1002/ddr.21976
- T‐17, a novel cyclin‐dependent kinases/histone deacetylases dual
inhibitor, induces cancer cells death through cell cycle arrest and
apoptosis-
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Authors:
Lin Zhang; Rui Long,
Xiaoli Li,
Junhao Jiang,
Huali Chen,
Binghua Tian,
Binyu Long,
Yu Yu,
Zongjie Gan
Abstract: Drug Development Research, EarlyView.
PubDate: 2022-07-17T09:09:36-07:00
DOI: 10.1002/ddr.21977
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