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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
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Research & Reviews : A Journal of Pharmacognosy
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ISSN (Online) 2394-7276
Published by STM Journals Homepage  [67 journals]
  • A Study on Nutraceutical Products in India: Need of Harmonization in
           Global Scenario

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      Authors: Shashi Kiran
      Pages: 1 - 9
      Abstract: AbstractDuring the study of regulatory guidelines for nutraceuticals and functional foods in India, it was noted that introduction of FSS act in 2006 was a major milestone in integrating of different food laws in India. The FSS act, replaced diverse local laws (such as PFA act. Essential commodity act etc.), post which the Indian regulatory structure of food products has meaningfully progressed. During this journey, the functional food and nutraceutical terminology came into being in 2016. With the introduction of FSSAI and implementation of regulations of functional food and nutraceuticals, a strong framework was established for nutraceuticals in India. Under these regulations, stringent guidelines have been laid down in the context of providing evidences to support health claims of nutraceutical products and to ensure the quality and safety of these products. Moreover, being elected as the regional coordinator for Codex in Asia, India has recognized itself at the international platform. For the registration of nutraceuticals in India, the product should comply with the quality requirements laid down in Indian Pharmacopoeia. Although the approval of existing nutraceutical ingredient can be granted based on usage history (minimum 15 years in India) in India; a requirement for adequate scientific evidence has been specified for a new ingredient approval which should include controlled clinical trials, nutra-epidemiological data and published scientific literature. Due to multiple different terminologies of health foods in India such as health supplement, nutraceuticals, food for special dietary use, FSMP; there are scenarios that applicants were submitting their applications under incorrect categories. FSSAI has tried to explain the difference between these categories along with the examples in 2020 gazette release to avoid any further confusion. Furthermore, the Indian regulatory system is also moving towards having a regulated system of collection and reporting of adverse events related nutraceutical/herbal products with AYUSH introducing a central sector scheme for post marketing adverse event reporting and collection of Ayurveda, Unani, Siddha and Homoeopathy drugs. Keywords: FSSAI, HCP, IOM, NDICitation: Shashi Kiran. A Study on Nutraceutical Products in India: Need of Harmonization in Global Scenario. Research & Reviews: A Journal of Pharmacognosy. 2022; 9(3): 1–9p
      PubDate: 2023-01-05
      DOI: 10.37591/rrjopc.v9i3.1236
      Issue No: Vol. 9, No. 3 (2023)
       
  • A Unani Perspective of Zeequn Nafas (Bronchial Asthma): A Brief
           Communication

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      Authors: Mudasir Maqbool, Irfat Ara
      Pages: 1 - 4
      Abstract: Zeequn Nafas is a widespread interaction of the bronchial system due to a number of influencing factors leading to chronic respiratory impairment. This respiratory impairment or Zeequn Nafas (Bronchial Asthma) has a wide clinical continuum, ranging from readily reversible bronchospasm to severe chronic intractable airflow obstruction. Bronchial asthma is the medical term used to describe Zeequn Nafas. The term Asthma is originated from the Greek word meaning short breathing, panting or labored breathing. Asthma is a complex airway disorder in which several cells and cell components participate. Despite the continuous research around the world, the successful and safe pharmacotherapy of Zeequn Nafas (Bronchial Asthma) continues to challenge the modern medical community. Corticosteroids and other bronchodilators suppress the immune system when used for long periods of time. Taking into account that diseases are the main phenomena of the body, Unani medicine believes in understanding the interaction between the powers of the body to maintain the reactions of the body to the diseases. Results from various research reports that substitute asthma treatments have played a prominent part in relieving symptoms. Interestingly, well-organized clinical studies still are required to illustrate on the effectiveness of treatment regimens. In this short communication, we will briefly review about Unani perspective of Zeequn Nafas (Bronchial Asthma).
      PubDate: 2022-08-29
      Issue No: Vol. 9, No. 2 (2022)
       
  • Description and Prevention of Omicron

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      Authors: Suhail M, Blessy Jacob, Visaga Perumal, Vineeth Chandy
      Pages: 5 - 16
      Abstract: November 9, 2021, Botswana becomes the first country to recognise it (Nov 11 2021). The new variant (B.1.529) has been represented in 77 countries. Omicron presents 32 changes in spike protein Scribd, restricting the point of interaction with the ACE2 receptor protein. Computational shows and components’ recreation has been applied to investigate the collaboration between the SARS-CoV-2 RBD and the ACE2 receptor. The receptor-binding domain (RBD), which more barely joins the ACE2 receptor in the omicron variety; this uncovered that the ACE2 receptor displays an improved restricting profile towards the S protein of the omicron variation when contrasted with the Delta variation. We initiated the changes either by cancellation, modification, or expansion to explain the all-around expected plan of S-protein for the Omicron variety, utilising the Alpha fold with 1268 amino acids, where the Omicron variation showed more than 30 transformations at various locals of S protein. We played out the phylogenetic investigation of all SARS-COV-2 variations, given that spike S protein introduced the longest transformative distance compared to other variants. The non-identical cluster arrangements shown by the omicron (VOC) and omicron S proteins contain 34 amino acid corrosive (AA) changes. AlphaFold2 is an open-source computational methodology created to assist us with obtaining exact protein structures given hereditary information. The progressions in the S, M, and N proteins of the as of late recognized SARS-CoV-2 Omicron assortment were contemplated, and various amino acids on RBD were adjusted, which might influence the collaboration between the RBD and ACE2, while the S309 immunizer may in any case be viable in killing Omicron RBD. The SARS-CoV-2 is classified as VOI (a variant of interest) and VOC (a variant of concern). The Omicron will come under the VOC because of its omicron-containing mutation gene.A SARS-CoV-2 VOI is a SARS-CoV-2 variation with innate changes that are expected or alluded to impact contamination characteristics like getting ailment reality and immune take off, suggestive or helpful break. The SARS-CoV-2 VOC (a variant of concern) is a SARS-CoV-2 variety that meets the importance of a VOI (a variant of interest) and is estimated through a similar estimation. The omicron cases in India are increasing every day in every state of India, especially Maharashtra, Karnataka, Kerala, Delhi, etc. Immunization with BNT162b2 has been shown to prompt killing sum neutralizer against the familial infection of 2.4-overlay of the mean gaining strength sum.It compromises the ability of the counter-acting agent to guarantee against contamination. In any case, much lower balance levels are adequate for insurance against serious infection. The Pfizer-Biotech immunisation could be essentially diminished against omicron with a 41-overlay lower level of killing neutralizer when contrasted with a variation of infection when compared with the previous variant characterised by spike protein substitution D614G. The third doses of the Pfizer immunization give a comparative degree of killing neutralizer against omicron as seen after two dosages against the first infection.When compared to wild types, individuals who received two doses of vaccine demonstrated a more than a 25-point decrease in balance titres against omicron suggesting that two dosages of the Pfizer vaccine may not be adequate to safeguard against illness with the omicron variety. The support piece of the ongoing vaccination grows the counter acting agent focus by 25-cross-over.
      PubDate: 2022-08-29
      Issue No: Vol. 9, No. 2 (2022)
       
  • Revolutionary Journey of Herbal Shampoo for Multiple Cosmetic
           Applications: An Imperative Review

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      Authors: Mayank Rajput, Lalit Sharma, Mamta Kadawla
      Pages: 17 - 23
      Abstract: Dandruff is a common scalp ailment caused by the yeast Pityrosporum that affects the majority of people. The condition of dandruff cannot be entirely removed; rather, it can only be efficiently managed and maintained. The three most typical signs of dandruff are particles on the scalp, scalp itching, and redness near the scalp. There are two approaches to treating dandruff. These anti-dandruff shampoos include chemical-based anti-dandruff shampoos and herbal-based anti-dandruff shampoos that include antibacterial and antifungal chemicals such as ketaconazole, sulphur dioxide, zinc pyrithione, and other similar substances. Hair loss, increased scaling, itching, irritation, nausea, headache, vomiting, and photosensitivity are all possible side effects of anti-dandruff shampoos, which not only slow down the peeling of the scalp but also have their own risks. Formulations made from herbal extracts are a feasible alternative to manufactured medications. There are now a large number of herbal shampoos on the market, and many contain herbal ingredients like plant herbal extracts. In this review, we will address the causes of dandruff, as well as synthetic chemicals, different herbs, and the assessment factors for anti-dandruff shampoo and conditioner.
      PubDate: 2022-08-29
      Issue No: Vol. 9, No. 2 (2022)
       
  • Formulation and Evaluation of Momordica charantia by Direct Compression
           Method

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      Authors: Sonia Thakur, Palak Agrawal, Morari radha raman, Anjali Sahu
      Pages: 24 - 29
      Abstract: The Momordica charantia herbal tablet was prepared by direct compression method. Various excipients used for the preparation of herbal tablet are such as Momordica charantia, MCC, Methyl Cellulose, Starch, and Sodium Benzoate. The anti-diabetic activity of Momordica charantia is due to their active ingredient that is present in their fruit part includes charantin, insulin-like peptide, cucurbitane, glycosides, Momordic in and oleanolic acid. The final tablet undergoes through post evaluation parameters such as hardness test, disintegration, friability, and weight variation.
      PubDate: 2022-08-29
      Issue No: Vol. 9, No. 2 (2022)
       
  • Medicinal Plants Used for the Management of Ulcer in Kano State, Nigeria

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      Authors: Umar Suleiman Abubakar
      Pages: 30 - 35
      Abstract: The present study was aimed at collecting, identifying and documenting medicinal plants used for the management of ulcer in Kano State, Nigeria. Open-ended informal interviews and general conversation were administered to thirty eight (38) traditional medical practitioners and herb sellers. The data collected included the local names of plants, parts used, method of preparations and mode of administration. A total number of seventeen (17) plant species belonging to twelve (12) families were collected, identified and documented. Acacia nilotica, Adansonia digitata, Moringa oleifera and Musa sapientum were the most frequently mentioned plants, while Fabaceae and Amaryllidaceae were the most frequently mentioned families. To the best of our knowledge, this is the first attempt to document the traditional knowledge and practices on the use of medicinal plants for the management of ulcer in Kano State, Nigeria, there is need to investigate the antiulcer activity of plant species that have not been evaluated, and the bioactive compounds responsible for the antiulcer activity need to be isolated, characterized and identified.
      PubDate: 2022-08-29
      Issue No: Vol. 9, No. 2 (2022)
       
 
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