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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted alphabetically
Microbial Drug Resistance     Hybrid Journal   (Followers: 3)
Molecular Informatics     Hybrid Journal   (Followers: 5)
Molecular Pharmacology     Hybrid Journal   (Followers: 2)
Molekul     Open Access   (Followers: 1)
Natural Product Communications     Open Access  
Nature Reviews Drug Discovery     Full-text available via subscription   (Followers: 318)
Naunyn-Schmiedeberg's Archives of Pharmacology     Hybrid Journal  
NeuroMolecular Medicine     Hybrid Journal  
Neuropharmacology     Hybrid Journal   (Followers: 6)
Neuropsychopharmacology     Hybrid Journal   (Followers: 18)
Neuropsychopharmacology Reports     Open Access  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Drug Design & Delivery     Open Access  
OA Medical Hypothesis     Open Access  
Obesity Facts     Open Access   (Followers: 8)
Open Pharmacoeconomics & Health Economics Journal     Open Access  
Open Pharmacology Journal     Open Access  
OpenNano     Open Access   (Followers: 1)
Orbital - The Electronic Journal of Chemistry     Open Access   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Pain and Therapy     Open Access   (Followers: 3)
Particulate Science and Technology: An International Journal     Hybrid Journal   (Followers: 1)
PDA Journal of Pharmaceutical Science and Technology     Full-text available via subscription   (Followers: 36)
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Pharmaceutical Care-La Farmacoterapia     Open Access  
Pharmaceutical Chemistry Journal     Hybrid Journal  
Pharmaceutical Development and Technology     Hybrid Journal   (Followers: 21)
Pharmaceutical Executive     Full-text available via subscription   (Followers: 6)
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Pharmaceutical Journal     Free   (Followers: 8)
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Pharmacological Research - Modern Chinese Medicine     Open Access  
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Pharmacology Research & Perspectives     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacopsychiatry     Hybrid Journal   (Followers: 3)
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy     Hybrid Journal   (Followers: 38)
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Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
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Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 15)
Pharmazie in Unserer Zeit (Pharmuz)     Hybrid Journal   (Followers: 18)
Physiology International     Full-text available via subscription   (Followers: 3)
Plant Products Research Journal     Full-text available via subscription  
Planta Medica     Hybrid Journal   (Followers: 4)
Planta Medica International Open     Open Access  
Prescriber     Hybrid Journal   (Followers: 9)
Progress in Neuro-Psychopharmacology and Biological Psychiatry     Hybrid Journal   (Followers: 8)
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PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Redox Report     Open Access  
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
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Research & Reviews : A Journal of Pharmacology     Full-text available via subscription   (Followers: 1)
Research in Pharmaceutical Sciences     Open Access   (Followers: 3)
Research in Social and Administrative Pharmacy     Hybrid Journal   (Followers: 3)
Research Journal of Pharmacognosy     Open Access  
Research Results in Pharmacology     Open Access  
Reviews of Physiology, Biochemistry and Pharmacology     Hybrid Journal   (Followers: 4)
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Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Revista Cubana de Plantas Medicinales     Open Access   (Followers: 1)
Revista de Ciências Farmacêuticas Básica e Aplicada     Open Access  
Revista Mexicana de Ciencias Farmaceuticas     Open Access  
Revue de Médecine et de Pharmacie     Full-text available via subscription  
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Saudi Pharmaceutical Journal     Open Access  
Scandinavian Journal of Clinical and Laboratory Investigation     Hybrid Journal   (Followers: 8)
Scientia Pharmaceutica     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Seminars in Oncology Nursing     Full-text available via subscription   (Followers: 10)
Separation Science plus (SSC plus)     Hybrid Journal  
Side Effects of Drugs Annual     Full-text available via subscription   (Followers: 2)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 6)
Substance Abuse : Research and Treatment     Open Access   (Followers: 5)
Suchttherapie     Hybrid Journal   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 5)
SynOpen     Open Access  
The Botulinum J.     Hybrid Journal  
The Brown University Psychopharmacology Update     Hybrid Journal   (Followers: 2)
The Medical Letter     Full-text available via subscription   (Followers: 18)
The Pink Sheet     Full-text available via subscription   (Followers: 12)
The Pink Sheet Daily     Full-text available via subscription   (Followers: 5)
Therapeutic Advances in Drug Safety     Open Access   (Followers: 3)
Therapeutic Advances in Psychopharmacology     Open Access   (Followers: 4)
Therapeutic Advances in Vaccines     Hybrid Journal   (Followers: 1)
Therapeutic Drug Monitoring     Hybrid Journal   (Followers: 5)
Therapeutic Innovation & Regulatory Science     Hybrid Journal   (Followers: 7)
Thérapie     Full-text available via subscription   (Followers: 1)
TheScientist     Free   (Followers: 6)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Toxicological Research     Hybrid Journal  
Toxicological Sciences     Hybrid Journal   (Followers: 11)
Toxicology     Hybrid Journal   (Followers: 19)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 25)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Toxicology in Vitro     Hybrid Journal   (Followers: 12)
Toxicology International     Full-text available via subscription   (Followers: 5)
Toxicology Letters     Hybrid Journal   (Followers: 16)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 9)
Toxicology Research     Partially Free   (Followers: 8)
Toxicon     Hybrid Journal   (Followers: 5)
Toxicon : X     Open Access  
Toxin Reviews     Hybrid Journal  
Translational Psychiatry     Open Access   (Followers: 14)
Trends in Peptide and Protein Sciences     Open Access  
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 21)
Tropical Journal of Pharmaceutical Research     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Vascular Pharmacology     Hybrid Journal   (Followers: 2)
World Mycotoxin Journal     Hybrid Journal   (Followers: 3)
Yakugaku Zasshi     Open Access   (Followers: 1)
Zeitschrift für Phytotherapie     Hybrid Journal   (Followers: 1)
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
Фармацевтичний часопис     Open Access  

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Planta Medica Letters
Number of Followers: 2  

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  • Pay What You Want
    • Planta Med Lett 2016; 3: e1-e1
      DOI: 10.1055/s-0035-1568217

      Georg Thieme Verlag KG Stuttgart · New York

      Article in Thieme eJournals:
      Table of contents     open access Full text

      Planta Med Lett 2016; 3: e1-e12016-01-01T00:00:00+0100
      Issue No: Vol. 3, No. 01 (2016)
  • In Vitro Rapid Multiplication Protocol for Ex Situ Conservation of the
           Rare, Endemic Medicinal Plant Achyranthes coynei

    • Authors: Desai; Mayuri, Hurkadale, Pramod J., Upadhya, Vinayak, Sailo, Lalrinsangi, Hegde, Harsha V., Pai, Sandeep R.
      Abstract: Achyranthes coynei is a rare, endemic species with potential medicinal properties. The present study aimed to develop an efficient in vitro rapid multiplication protocol for A. coynei. It was successfully propagated in vitro using apical shoot tips as explants. A combination of 6-benzylaminopurine (3.0 mg · L−1), thidiazuron (0.5 mg · L−1), and kinetin (0.5 mg · L−1) in MS basal proved best for multiple shoot induction, yielding 4.8 shoots per explant after 60 days of culture. The shoots were rooted with a frequency of 80 % after 30 days of culture on MS agar medium fortified with IBA/NAA (0.5 mg · L−1) before being acclimatized in the greenhouse. The developed protocol will serve as a tool to restore the rare status of the plant and will append its sustainable utilization.
      Citation: Planta Med Lett ; : -
      PubDate: 2016-04-28T00:00:00+01:00
      DOI: 10.1055/s-0042-105296
  • Structural Characterization, In Silico Studies and In Vitro Antibacterial
           Evaluation of a Furanoflavonoid from Karanj

    • Authors: Singh; Anuma, Jahan, Iffat, Sharma, Mrinal, Rangan, Latha, Khare, Alika, Panda, Aditya N
      Abstract: Pongamia pinnata, popularly referred to as Karanj, is a multipurpose legume well known for its traditional and pharmacological properties with an efficient remedy for human health problems. Karanjin, a furanoflavonoid (3-methoxy-2-phenylfuro [2,3-h] chromen-4-one), is the main constituent of Karanj seeds with important biological attributes. The present investigation was aimed at standardizing a process for the isolation of karanjin from seed oil with an emphasis on achieving a higher yield of the pure compound. Structural elucidation and characterization were carried out via HRMS, Fourier transform infrared spectroscopy, X-rays diffraction, NMR, Raman spectroscopy, and thermogravimetric studies. The optimized geometry of the karanjin compound has been determined by a density functional theory and compared with experimental values, which are in excellent agreement. The potency of karanjin against pathogenic indicators was evaluated and confirmed by Raman scattering and field emission scanning electron microscopy imaging. The physicochemical parameters of karanjin were determined by in silico drug likeness properties, and molecular docking was also performed, which revealed the potential of karanjin as a highly functionalized and medicinally useful compound. From the docked conformations, the carbonyl group, 3-methoxy group, and oxygen atom in the C ring of the karanjin molecule were found to be biologically important for hydrogen bond formation with common bacterial enzymes involved in fatty acid biosynthesis. The mode of antibacterial action of karanjin revealed the complex patterns of probable cell wall disruption. This is the first report with regard to karanjin characterization and theoretical calculations of a density functional theory and its utility as a potential pharmacophore depicting an antibacterial property using Raman spectroscopy and docking studies.
      Citation: Planta Med Lett ; : -
      PubDate: 2016-04-26T00:00:00+01:00
      DOI: 10.1055/s-0042-105159
  • A New Dinor-cis-Labdane Diterpene and Flavonoids with Antimycobacterium
           Activity from Colebrookea oppositifolia

    • Authors: Chinchansure; Ashish A., Arkile, Manisha, Shinde, Dinesh R., Sarkar, Dhiman, Joshi, Swati P.
      Abstract: The new 14,15-dinor-cis-labdane diterpene, named (+)-14,15-dinor-9α-hydroxy-cis-labd-11(E)-en-13-one (1), was isolated from the acetone extract of the aerial parts of Colebrookea oppositifolia, along with the known compounds alnustin (2), mosloflavone (3), flindulatin (4), 5,6,7-trimethoxy baicalein (5), tanetin (6), scutellarein 4′-methyl ether (7), apigenin (8), caffeic acid (9), anisofolin A (10), apigetrin (11), and forsythoside A (12). Structures of the new and known compounds were established by detailed analysis of 1D and 2D nuclear magnetic resonance studies. The isolated compounds 1–12 were evaluated for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis in both dormant and active phases. Compounds 1, 7, and 8 exhibited inhibitory activity against M. tuberculosis with IC50 values in the range of 8.1–55.0 µM (MIC 14.4–119.7 µM) in the active phase and 7.4–43.5 µM (MIC 11.5–123.3 µM) in the dormant phase. Similarly 1, 7, and 8 exhibited inhibitory activity against M. bovis with IC50 values in the range of 4.1–98.5 µM (MIC 13.7–161.0 µM) in the active phase and 4.1–111.1 µM (MIC 13.0–166.4 µM) in the dormant phase.
      Citation: Planta Med Lett ; : -
      PubDate: 2016-03-14T00:00:00+0100
      DOI: 10.1055/s-0042-102200
  • Brachiaria plantaginea as a Potential (New) Source of Shikimic Acid.
           Quantification by NIR and PLS Regression

    • Authors: Costa; Maria Cristina A., Matallo, Marcus B., Ferreira, Márcia M. C., Queiroz, Sonia C. N., de Almeida, Sydnei B. Dionísio, de Siqueira Franco, Daniel A.
      Abstract: Shikimic acid is a natural organic compound produced in the biochemical pathways of eukaryotic organisms and is generally utilized as a starting material of the antiviral drug Oseltamivir (Tamiflu®). This study shows the results of shikimic acid accumulation in Brachiaria plantaginea, an abundant, grassy plant found in Brazil and other countries in Africa and America, after glyphosate spraying at three different doses. B. plantaginea plants harvested after 6 days of exposure to the herbicide showed that shikimic acid accumulation increased by 345 %, on average, compared to unsprayed plants. The combination of near infrared spectroscopy and multivariate analysis using partial least square regression was applied for the quantification of shikimic acid in B. plantaginea. Spectra of 44 samples were obtained using the diffuse reflectance mode in the range of 4000 to 10 000 cm−1 with 4 cm−1 resolution. Different mathematical pretreatments were applied to the spectra. As preprocessing, the data were mean-centered. The calibration model with seven factors on twenty-nine samples (training set) exhibited a coefficient of determination = 0.9930 and a standard error of calibration = 84.05. For external validation (11 samples on the test set), the coefficient of determination = 0.9317 and the standard error of prediction = 154.91. The percent calibration error range was 1 to 10 % for most of the samples and only two samples presented an error greater than 20 %. For external validation, the mean prediction error was 10 % and the range error ratio was 9.42, indicating that the model is qualified for screening calibration.
      Citation: Planta Med Lett ; : -
      PubDate: 2016-03-14T00:00:00+0100
      DOI: 10.1055/s-0042-102202
  • Miconidin Acetate and Primin as Potent 5-Lipoxygenase Inhibitors from
           Brazilian Eugenia hiemalis (Myrtaceae)

    • Authors: Zatelli; Gabriele Andressa, Temml, Veronika, Kutil, Zsofia, Landa, Premysl, Vanek, Tomas, Schuster, Daniela, Falkenberg, Miriam
      Abstract: This paper describes the isolation and identification of primin and miconidin acetate as metabolites from the flower bud extract of Eugenia hiemalis as well as the anti-inflammatory activity of miconidin acetate by inhibition of 5-lipoxygenase. Miconidin acetate inhibited leukotriene B4 formation catalyzed by the human recombinant enzyme (IC50 = 0.3 ± 0.17 µM) more than primin (IC50 = 1.4 ± 0.6 µM) and zileuton (IC50 = 1.1 ± 0.7 µM). Miconidin acetate (20 µM) inhibited LTB4 formation to an extent of 59 ± 12 % in vitro using a cell-based assay, comparable to the positive control zileuton (69 ± 12 % inhibition at a concentration of 10 µM). The binding modes of miconidin acetate were further evaluated in silico by molecular docking to the human 5-lipoxygenase crystal structure. The hydroxyl group was predicted to form a hydrogen bond with the terminal Ile676, while the pentyl moiety occupied the hydrophobic substrate channel. The obtained results show that flower buds of E. hiemalis are an interesting source of anti-inflammatory compounds, mainly of miconidin acetate.
      Citation: Planta Med Lett ; : -
      PubDate: 2016-03-14T00:00:00+0100
      DOI: 10.1055/s-0042-102460
  • Structural Derivatization of Clusianone and In Vitro Cytotoxicity
           Evaluation Targeting Respiratory Carcinoma Cells

    • Authors: Nagalingam; Sree Vaneesa, Wai-Ling, Kok, Teng-Jin, Khoo
      Abstract: Clusianone (1) was isolated from Garcinia parvifolia and structurally modified using semisynthetic methods to obtain compounds 2–4. The structural derivatization included methylation (2), hydrogenation (3), and the addition of a methylamine group [(4) to (1)]. Cytotoxic effects of these compounds were assessed on MRC5 fibroblasts, A549 lung adenocarcinoma, HK1 squamous nasopharynx carcinoma, and NP69 normal nasopharyngeal epithelial cell lines. Clusianone (1) showed cytotoxic activity against A549 cells with an IC50 value of 3.06 µM. Compound (4) showed cytotoxic activities against both A549 and HK1 cells with IC50 values of 4.09 µM and 3.43 µM, respectively. The results of the cytotoxicity assay provide a correlation on the structure activity relationship of clusianone against HK1 and A549 cells, which can be further investigated as a potential antiproliferative compound.
      Citation: Planta Med Lett ; : -
      PubDate: 2016-02-11T00:00:00+0100
      DOI: 10.1055/s-0035-1568332
  • Antiproliferative Butyrolactones from Mezilaurus crassiramea

    • Authors: Tófoli; Danilo, Martins, Laura Alves Verão, Matos, Maria de Fátima Cepa, Garcez, Walmir Silva, Garcez, Fernanda Rodrigues
      Abstract: Bioassay-guided fractionation of the ethanol extract from the leaves of Mezilaurus crassiramea, which was toxic to Artemia salina larvae, afforded 3′-acetylrubrenolide (1), 2′,3′-diacetylrubrenolide (2), and rubrenolide (3) from the active dichloromethane soluble fraction. Compound 1 is new, while 2 and 3 are first reported from a natural source and in the Mezilaurus genus, respectively. Compound 3 showed significant cytotoxicity against UACC-62, MCF-7, HT-29, and PC-3 human cancer cell lines, with GI50 values ranging from 3.3 to 9.9 µg/mL, while 1 and 2 exhibited marginal activities against at least five of the six investigated cell lines. The structures of 1–3 were established on the basis of 1D- and 2D-nuclear magnetic resonance analyses, high-resolution electrospray ionization mass spectrometry data and specific optical rotation values.
      Citation: Planta Med Lett ; : -
      PubDate: 2016-02-11T00:00:00+0100
      DOI: 10.1055/s-0035-1568355
  • Structure Revision of Four Acylphloroglucinols Isolated from the Leaves of
           Syzygium polyanthum

    • Authors: Carroll; Anthony R.
      Abstract: The structures of four 1-acyl-2,3,5-trihydroxybenzene derivatives (1–4) that inhibit the enzyme protein tyrosine phosphatase 1B, previously reported from the leaves of Syzygium polyanthum, have been revised based upon reinterpretation of NMR spectroscopic data. The corrected structures are all 1-acylphloroglucinol derivatives (5–8).
      Citation: Planta Med Lett ; : -
      PubDate: 2016-02-05T00:00:00+0100
      DOI: 10.1055/s-0035-1568260
  • Natural Triterpene Glycosides for Antibody Recognition

    • Authors: Peroni; Elisa, Real Fernández, Feliciana, Gheri, Caterina, Nuti, Francesca, Mitaine-Offer, Anne-Claire, Lolli, Francesco, Lacaille-Dubois, Marie-Aleth, Papini, Anna-Maria
      Abstract: Multiple sclerosis is an autoimmune disease that affects the central nervous system. The key role of the glycosylation in disease pathogenesis has been previously studied and the synthetic N-glucosylated peptide CSF114(Glc) proved its efficiency in autoantibody recognition in the sera of multiple sclerosis patients. Herein, pure natural triterpene glycosides containing different glycosyl moieties were isolated and tested in multiple sclerosis patientsʼ sera to better understand the role of glycosylation. They were selected taking into account the nature and complexity of their osidic part. Five triterpene glycosides were isolated from several plants with more than 95 % purity. The interaction between these glycosides and autoantibodies was evaluated in an enzyme-linked immunosorbent assay measuring IgG and IgM levels in multiple sclerosis patients and healthy blood donors, and the results were compared with those of CSF114(Glc). For each antigen, Mann Whitney and receiver operating characteristic-based analysis were performed to evaluate any statistical significance of the results. The five natural triterpene glycosides showed good capacity to recognize IgMs (sensitivity up to 38 %) with a high specificity (88.9 %) for multiple sclerosis patients.
      Citation: Planta Med Lett ; : -
      PubDate: 2016-02-05T00:00:00+0100
      DOI: 10.1055/s-0035-1568263
  • The Evidence for the Production Mechanism of cis-S-1-Propenylcysteine in
           Aged Garlic Extract Based on a Model Reaction Approach Using Its Isomers
           and Deuterated Solvents

    • Authors: Kodera; Yukihiro, Matsutomo, Toshiaki, Itoh, Kenji
      Abstract: cis-S-1-Propenylcysteine has been identified in aged garlic extract, however, its production mechanism is still unclear. The content of cis-S-1-propenylcysteine in aged garlic extract at 22 months of aging was more than twice the molarity of γ-glutamyl-cis-S-1-propenylcysteine in raw garlic, a plausible precursor of cis-S-1-propenylcysteine. We found that cis-S-1-propenylcysteine was generated through the isomerization of trans-S-1-propenylcysteine in the model reactions. These results suggested that the isomerization was induced by the electron-releasing conjugative effect of the sulfur atom in S-1-propenylcysteine.
      Citation: Planta Med Lett 2015; 2: e69-e72
      PubDate: 2015-12-21T00:00:00+0100
      DOI: 10.1055/s-0035-1558260
      Issue No: Vol. 2, No. 01 (2015)
  • Cytotoxic Norhopene Triterpenoids from the Bark of Exothea paniculata from
           Abaco Island, Bahamas

    • Authors: Chhetri; Bhuwan K., Dosoky, Noura S., Setzer, William N.
      Abstract: Bioactivity-directed preparative chromatography of the cytotoxic crude dichloromethane bark extract of Exothea paniculata has yielded two new cytotoxic norhopene triterpenoids, exotheol A and exotheol B. The structures were determined by nuclear magnetic resonance and high-resolution mass spectrometry and were found to be potently cytotoxic to MCF-7 and 5637 cells in vitro.
      Citation: Planta Med Lett 2015; 2: e73-e77
      PubDate: 2015-12-21T00:00:00+0100
      DOI: 10.1055/s-0035-1558261
      Issue No: Vol. 2, No. 01 (2015)
  • Formation of a Predominant Metabolite of Hydroxydihydrocarvone Evaluated
           by a Biomimetic Oxidative Model and in Rat Liver Microsomes

    • Authors: Thomazzi; Sara M., Moreira, Fernanda L., Turatti, Izabel C. C., Paula e Souza, Juliana N., Andrade, Luciana N., Silva, Denise B., Oliveira, Anderson R. M., De Sousa, Damião P., Lopes, Norberto P.
      Abstract: This paper reports the biomimetic oxidation of hydroxydihydrocarvone by iodosylbenzene using tetraphenyl-porphine iron(III) chloride as the catalyst in ethyl acetate. Mass spectrometry fragmentation maps of hydroxydihydrocarvone (obtained by gas chromatography-mass spectrometry analyses) allowed for the identification of the major product as 4-hydroxy-5-(2-hydroxypropan-2-yl)-2-methylcyclohex-2-en-1-one (4-hydroxy-hydroxydihydrocarvone). This compound was also observed in an in vitro metabolism assay that employed isolated rat liver microsomes, thereby validating the biomimetic procedure.
      Citation: Planta Med Lett 2015; 2: e61-e64
      PubDate: 2015-11-17T00:00:00+0100
      DOI: 10.1055/s-0035-1558206
      Issue No: Vol. 2, No. 01 (2015)
  • Development of an Authentication System for Genuine Radix Salviae
           Miltiorrhizae (Salvia miltiorrhiza) Using SNP Markers

    • Authors: Zhang; Tiantian, Wang, Jing, Wang, Di, Wang, Hongtao
      Abstract: Radix Salviae Miltiorrhizae (Salvia miltiorrhiza) is one of the most widely used traditional Chinese medicinal materials. However, the dried roots of Salvia przewalskii, Salvia yunnanensis, Salvia sinica, and Salvia digitaloides are usually mistaken for Radix Salviae Miltiorrhizae due to their similarity in appearance. Although several efforts have been made to develop molecular markers for Salvia species, the discrimination of Radix Salviae Miltiorrhizae from its adulterants is still an unresolved problem. In order to develop a simple and reliable method for identifying genuine Radix Salviae Miltiorrhizae, the nuclear internal transcribed spacer region was analyzed to exploit DNA polymorphisms, and a host of single nucleotide polymorphism sites were discovered among five Salvia species. By introducing additional mismatches, allele-specific primers were designed and a multiplex polymerase chain reaction was conducted for authentication of Radix Salviae Miltiorrhizae. The established multiplex allele-specific polymerase chain reaction system enabled the simultaneous identification of four Salvia species in one reaction. Therefore, a simple and reliable method for molecular authentication of S. miltiorrhiza from its adulterants was established, and the present method should be an important tool to complement morphological and chemical analysis for quality control of Radix Salviae Miltiorrhizae.
      Citation: Planta Med Lett 2015; 2: e65-e68
      PubDate: 2015-11-17T00:00:00+0100
      DOI: 10.1055/s-0035-1558205
      Issue No: Vol. 2, No. 01 (2015)
  • Interaction of Vietnamese Medicinal Plant Extracts with Recombinantly
           Expressed Human Neurokinin-1 Receptor

    • Authors: Dinh; Long Doan, Pham, Nhung Hong Thi, Thi Hoang, Nhung My, Tat, Cuong Trinh, Thi Nguyen, Van Hong, Thi Vo, Lan Thuong, Pham, Huyen Thanh, Lundstrom, Kenneth
      Abstract: A primary functional receptor screening assay was performed to examine the effects of methanolic extracts from ten Vietnamese medicinal plants on the human neurokinin-1 receptor expressed from Semliki Forest virus vectors in Chinese hamster ovary cells. Extracts from Piper nigrum, Stephania cambodica and Styphnolobium japonicum were found to exert inhibition on agonist-induced human neurokinin-1 receptor activity. Secondary assays and high performance liquid chromatography of the lead compounds addressed a possible association between pharmacological responses and these chemical compounds. Strong inhibition of human neurokinin-1 receptor was observed for extracts revealing the highest inhibitory potency for rotundine (tetrahydropalmatine) in S. cambodica extracts with IC50 of 0.88 µM, followed by piperine and capsaicin in P. nigrum extracts with IC50 values of approximately 2 µM, whereas rutin in S. japonicum extracts failed to inhibit hNK1R up to 100 µM.
      Citation: Planta Med Lett 2015; 2: e42-e47
      PubDate: 2015-11-06T00:00:00+0100
      DOI: 10.1055/s-0035-1558100
      Issue No: Vol. 2, No. 01 (2015)
  • Semi-Synthesis of Kaurenoic Acid Derivatives and Their In Vitro Cytotoxic

    • Authors: Zhang; Lei, Wang, Fei, Ma, Xin-hua, Zhou, Fang, Wen, Sheng-mei, Zhong, Tian-hua, Liu, Quan-yu, Chen, Shi-wu, Zhang, Yong-hong
      Abstract: The cytotoxic activities of the diterpene kaurenoic acid (1) and its 15 semi-synthesis derivatives were assessed on human cell cultures. The human tumor cells used comprised colon (SW620 and SW480), pancreatic (PANC-1 and BxPC-3), stomach (SGC-7901), esophageal (Eca-109), and leukemia (K562 and HL-60). Kaurenoic acid was inactive against the tumor cell lines; however, its derivatives which contain α,β-unsaturated ketone rendered compounds with cytotoxic activity. Compounds 5–14, 17–19, and 24 with a substitution at the C-4 position showed significant inhibitory activity against the tested cell lines, while compound 3, without a substitution at the C-4 position, was slightly less active in these cell lines. The SW620 colon cancer cell was highly susceptible to all of the tested derivatives.
      Citation: Planta Med Lett 2015; 2: e48-e51
      PubDate: 2015-11-06T00:00:00+0100
      DOI: 10.1055/s-0035-1557861
      Issue No: Vol. 2, No. 01 (2015)
  • Protective Effect of Proteins Derived from Seed Explant Cultures of
           Calotropis procera in a Preclinical Model of Arthritis

    • Authors: Kumar; Vijay L., Sharma, Nisha, Ramos, Márcio V., Silva, Rayanne F., Carvalho, Cristina P. S.
      Abstract: Proteins isolated from the in vitro cultures of callus and roots developed from the germinating seed explants of Calotropis procera were evaluated for their protective effect in a rat model of arthritis at 1 and 5 mg/kg doses in two independent sets of experiments comprising of respective controls. Joint swelling, functional parameters, markers of inflammation, oxidative stress, tissue histology, and cyclooxygenase-2 expression in these rats were compared with those treated with the standard anti-inflammatory drug diclofenac on day 3. Both callus and root proteins produced a dose-dependent reduction in joint swelling, and at the 5-mg/kg dose, their inhibitory effect was more pronounced (57 and 55 % inhibition) than that of diclofenac (42 and 46 % in two sets). Both of the protein fractions alleviated functional limitations in arthritic rats and normalized the levels of prostaglandin E2, tumor necrosis factor-α, and other biochemical markers of inflammation and oxidative stress, maintained tissue architecture, and suppressed cyclooxygenase-2 expression compared to arthritic controls. This study demonstrates that the proteins derived from the in vitro culture of C. procera explants have potential in the treatment of arthritis.
      Citation: Planta Med Lett 2015; 2: e52-e56
      PubDate: 2015-11-06T00:00:00+0100
      DOI: 10.1055/s-0035-1558154
      Issue No: Vol. 2, No. 01 (2015)
  • Structural Elements of an Antioxidative Pectic Arabinogalactan from
           Solanum virginianum

    • Authors: Raja; Washim, Ghosh, Kanika, Ray, Bimalendu
      Abstract: The water-soluble polysaccharide-containing fraction from Solanum virginianum leaves upon anion exchange chromatography yielded a highly branched pectic arabinogalactan-containing fraction (F2). Herein, direct evidences for the (i) presence of a chain having 1,6-linked Gal units substituted at O-3, (ii) coexistence of Ara and Gal residues in the same molecule, (iii) existence of a chain containing 1,3-linked Galp residues substituted at C-6, and (iv) occurrence of 1,5-linked Araf residues substituted at O-3 were presented. This polysaccharide that showed a dose-dependent antioxidative property formed a water-soluble complex with bovine serum albumin. Thus, F2 could be used as a natural ingredient in functional food and pharmaceutical products to mollify oxidative stress.
      Citation: Planta Med Lett 2015; 2: e57-e60
      PubDate: 2015-11-03T00:00:00+0100
      DOI: 10.1055/s-0035-1558167
      Issue No: Vol. 2, No. 01 (2015)
  • Assessment of the Effect of Arbutin Isomers and Kojic Acid on Melanin
           Production, Tyrosinase Activity, and Tyrosinase Expression in B16-4A5 and
           HMV-II Melanoma Cells

    • Authors: Kai; Hisahiro, Matsuno, Koji
      Abstract: The inhibitory effects of α-arbutin, β-arbutin, and kojic acid on melanogenesis, tyrosinase activity, and tyrosinase protein expression in mouse melanoma cells (B16-4A5) and human melanoma cells (HMV-II) were directly compared. β-Arbutin showed a stronger inhibitory effect on melanogenesis and tyrosinase expression in B16-4A5 cells than α-arbutin and kojic acid. Kojic acid showed a stronger inhibitory effect on mushroom and B16-4A5 tyrosinase activity than α-arbutin and β-arbutin. In contrast, kojic acid inhibited all of these effects more strongly than α-arbutin or β-arbutin in HMV-II cells. These results suggest that kojic acid may be used as a positive control for the inhibitory melanogenesis assay, and for tyrosinase activity and tyrosinase expression assays that use HMV-II cells. Moreover, using HMV-II cells with kojic acid as the positive control may facilitate the search for new skin-whitening agents using natural products and provide an alternative to the B16-4A5 assay.
      Citation: Planta Med Lett 2015; 2: e39-e41
      PubDate: 2015-09-09T00:00:00+01:00
      DOI: 10.1055/s-0035-1557833
      Issue No: Vol. 2, No. 01 (2015)
  • Leucas mollissima, a Source of Bioactive Compounds with Antimalarial and
           Antimycobacterium Activities

    • Authors: Chinchansure; Ashish A., Arkile, Manisha, Shukla, Anurag, Shanmugam, Dhanasekaran, Sarkar, Dhiman, Joshi, Swati P.
      Abstract: A phytochemical investigation of the acetone extract from the aerial parts of Leucas mollissima afforded one new (−)epi-marmelo lactone, (2 S, 4R, 6 S)-2,6-dimethyl-6 hydroxy-7-ene-4-olide (1), along with five known compounds, schensianol A (2), vanillin (3), β-hydroxy propiovanillone (4), lanost-9(11),25-diene-3β,24β-diol (5), and lanost-9(11),23E(24)-diene-3β,25-diol (6). Similarly, an investigation of the methanol extract of the aerial parts of L. mollissima resulted in the isolation of three known compounds, (+)-syringaresinol (7), anisofolin A (8), and apigenin 7-O-β-D(− 6′′-p-E-coumaroyl)-glucoside (9). Structure elucidation of the isolated compounds was carried out using detailed analysis of 1D and 2D nuclear magnetic resonance. All compounds were evaluated for antimalarial activity against Plasmodium falciparum (3D7) and for antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis. Compound 8 was found to have promising antimalarial activity (IC50 4.39 ± 0.25 µM), promising antimycobacterium activity [IC50 4.50 ± 0.75 µM (3.31 µg/mL)] against M. tuberculosis H37Ra and at 100 µg/mL, showed 55.6 % inhibition of M. bovis. Compound 9 showed moderate inhibition of P. falciparum growth (35 % inhibition at 10 µM) with respect to the positive control atovaquone and 67.4 % inhibition against M. bovis at 100 µg/mL with respect to the positive control rifampicin.
      Citation: Planta Med Lett 2015; 2: e35-e38
      PubDate: 2015-09-04T00:00:00+01:00
      DOI: 10.1055/s-0035-1557830
      Issue No: Vol. 2, No. 01 (2015)
  • Two Novel Guaiane Sesquiterpenes from the Whole Plant of Youngia japonica

    • Authors: Lee; Ji Young, Cha, Mi-Ran, Kim, Mi Ri, Lee, Kwangho, Choi, Sang-Un, Ryu, Shi Yong
      Abstract: Two new guaiane-type sesquiterpenes (1 and 2) together with eight related sesquiterpenoidal constituents (3–10) were isolated from the whole extract of Youngia japonica. The chemical structures of 1–10 were established by spectroscopic analyses as 4-epi-isolipidiol (1), 4′-p-hydroxyphenylacetyl crepiside E (2), isolipidiol (3), isoambeboin (4), grosheimin (5), annuionone D (6), loliolide (7), youngiajaponicoside A (8), crepiside H (9), and crepiside E (10), respectively. Among the isolated components, 5 exhibited a significant inhibitory effect on the proliferation of cultured human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15).
      Citation: Planta Med Lett 2015; 2: e31-e34
      PubDate: 2015-08-06T00:00:00+01:00
      DOI: 10.1055/s-0035-1557794
      Issue No: Vol. 2, No. 01 (2015)
  • Cytokine-Suppressive Activity of a Hydroxylated Alkylamide from Echinacea

    • Authors: Leyte-Lugo; Martha, Todd, Daniel A., Gulledge, Travis V., Juzumaite, Monika, Carter, Frederick S., Laster, Scott M., Cech, Nadja B.
      Abstract: Echinacea purpurea has been widely used to treat upper respiratory tract infections. Bioassay-guided fractionation of hexane and ethanol extracts of this plant yielded 4[(2-methylbutyl)amino]-4-oxo-2-butenoic acid (1) and 8,11-dihidroxy-dodeca-2E,4E,9E-trienoic acid isobutylamide (2), both of which are new to Echinacea. Compound 2 suppressed the production of TNF-α from RAW 264.7 cells with an IC50 value of 6.8 µM, while 1 was inactive. Neither compound showed cytotoxicity at concentrations up to 100 µM. These findings support a growing body of literature demonstrating that E. purpurea contains an array of compounds that suppress cytokine secretion by macrophage-type cells in vitro.
      Citation: Planta Med Lett 2015; 2: e25-e27
      PubDate: 2015-08-04T00:00:00+01:00
      DOI: 10.1055/s-0035-1557764
      Issue No: Vol. 2, No. 01 (2015)
  • Rottlerin Derivatives and Other Compounds from Mallotus philippinensis
           Fruits and Their Potential Antimycobactrial Activity

    • Authors: Bharadwaj; Rima, Chinchansure, Ashish A., Kulkarni, Roshan R., Arkile, Manisha, Sarkar, Dhiman, Joshi, Swati P.
      Abstract: The methanolic extract of the fruits of Mallotus philippinensis afforded 13 compounds, 7,11-diketo-lanost-3-ol (1, as acetate), lanosta-8-ene-3β-ol (2, as acetate), pregnenolone (3, as acetate), trans-chalcone (4), kamalachalcone E (5), oleanolic acid (6), gallic acid (7), kaempferol (8), myricetin (9), 1-(5,7-dihydroxy-2,2,6-trimethyl-2 H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one (10), 4′-hydroxyisorottlerin (11), rottlerin (12), and shikimic acid (13). Compound 1 was isolated as a new natural product and its structure was elucidated by 1D and 2D nuclear magnetic resonance analyses including heteronuclear single quantum correlation, heteronuclear multiple-bond correlation, correlation spectroscopy, and nuclear Overhauser effect spectroscopy experiments. All of the isolated compounds were evaluated for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra. Compounds 11 and 12 exhibited promising inhibitory activity with IC50 values of 0.89 ± 0.33 µg/mL (MIC 2.06 ± 0.41 µg/mL) and 7.59 ± 0.42 µg/mL (MIC 11.56 ± 0.35 µg/mL), respectively.
      Citation: Planta Med Lett 2015; 2: e28-e30
      PubDate: 2015-08-04T00:00:00+01:00
      DOI: 10.1055/s-0035-1557793
      Issue No: Vol. 2, No. 01 (2015)
  • Protective Effect of Anthocyanidins on Astrocytes and Apoptosis Induced by
           Oxidative Damage

    • Authors: López; Ana, Palomino, Olga, Ortega, Teresa, Carretero, Emilia
      Abstract: As a result of the longer life expectancy in the human population, neurodegenerative diseases are increasing, so finding effective treatments together with prevention strategies are urgently needed. Anthocyanins are polyphenolic compounds from vegetal species that have shown strong antioxidant and anti-inflammatory activities in various experimental models. The effect of the anthocyanidins cyanidin, malvidin, and pelargonidin at different concentrations (5 to 100 µM) on experimental models of cell oxidation and apoptosis was studied and compared with the positive control Trolox. The human astrocyte glioblastoma, cellular line U373, was used for a cellular injury model using Fentonʼs reagent (0.5 mM FeSO4/1 mM H2O2) and to measure the lactate dehydrogenase enzyme activities and lipid peroxidation level (thiobarbituric acid reactive substances) by fluorimetric analysis and malondialdehyde release by HPLC. Also, caspase 3, 8, and 9 activities were measured by fluorimetric analysis. The results show that the studied anthocyanidins are able to revert the induced apoptosis related to caspase activation and lipid peroxidation. All the assayed anthocyanidins significantly decreased the activation of caspases 8 and 3, although malvidin and cyanidin increased the activity of caspase 9 when compared to non-treated cells.
      Citation: Planta Med Lett 2015; 2: e19-e24
      PubDate: 2015-05-06T15:31:14+01:00
      DOI: 10.1055/s-0035-1545938
      Issue No: Vol. 2, No. 01 (2015)
  • Upregulatory Effects of Nobiletin, a Citrus Flavonoid with Anti-dementia
           Activity, on the Gene Expression of mAChR, ChAT, and CBP

    • Authors: Kimura; Junko, Shimizu, Kosuke, Takito, Jiro, Nemoto, Kiyomitsu, Degawa, Masakuni, Yokosuka, Akihito, Mimaki, Yoshihiro, Oku, Naoto, Ohizumi, Yasushi
      Abstract: We previously showed that nobiletin, a polymethoxylated flavone from the peels of Citrus depressa Hayata, improves impaired memory in dementia model animals. It was also reported that nobiletin stimulates cAMP response element-dependent transcription through activation of the cAMP response element-binding protein signaling pathway. To determine whether nobiletin alters the expression of genes involved in learning and memory, we performed real-time polymerase chain reaction after treating PC12 cells with nobiletin. Nobiletin upregulated the expression of muscarinic acetylcholine receptor subtype M1, choline acetyltransferase, and cAMP response element-binding protein genes in the cells. The muscarinic acetylcholine receptor M1 and choline acetyltransferase mRNA levels reached maximum values at 6 h after nobiletin treatment, whereas the cAMP response element-binding protein mRNA levels peaked at 12 h. These results suggest that nobiletin enhanced the expression of genes involved in learning and memory by stimulating the cAMP response element-dependent transcription.
      Citation: Planta Med Lett 2015; 2: e12-e14
      PubDate: 2015-04-23T10:02:36+01:00
      DOI: 10.1055/s-0035-1545937
      Issue No: Vol. 2, No. 01 (2015)
  • Neuroprotective Effect of Demethylsuberosin, a Proteasome Activator,
           against MPP+-induced Cell Death in Human Neuroblastoma SH-SY5Y Cells

    • Authors: Kim; Bo-Hyung, Kwon, Jaeyoung, Lee, Dongho, Mar, Woongchon
      Abstract: Demethylsuberosin isolated from the roots of Cudrania tricuspidata demonstrated a potent proteasome activator by enhancing all three chymotrypsin-like, trypsin-like, and caspase-like proteasome activities in a 20S proteasome activity assay. It also attenuated the 1-methyl-4-phenylpyridinium-induced dysfunction of the chymotrypsin-like and caspase-like activities of proteasome in SH-SY5Y cells with EC50 values of 0.76 µM and 0.82 µM, respectively. Additionally, demethylsuberosin protected neuronal cells against 1-methyl-4-phenylpyridinium-induced cell death with an EC50 value of 0.17 µM, while the EC50 value of betulinic acid was 4.29 µM. We are reporting that demethylsuberosin is a potent proteasome activator with a neuroprotective effect, suggesting a possible candidate for the protection or treatment of neurodegenerative diseases such as Parkinsonʼs disease.
      Citation: Planta Med Lett 2015; 2: e15-e18
      PubDate: 2015-04-23T10:02:34+01:00
      DOI: 10.1055/s-0035-1545936
      Issue No: Vol. 2, No. 01 (2015)
  • Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum
           heterophyllum Leaves against Malaria

    • Authors: Ledoux; Allison, Maraetefau, Hinerava, Jansen, Olivia, Etienne, Delphine, Quetin-Leclercq, Joëlle, Clerc, Patricia, Smadja, Jacqueline, Frédérich, Michel
      Abstract: The aim of this study was to evaluate the antiplasmodial properties of Zanthoxylum heterophyllum, an endemic plant from the Mascarene Islands. In vitro antiplasmodial activity of ethyl acetate and dichloromethane crude extracts obtained from leaf samples collected on Reunion Island was evaluated on the Plasmodium falciparum 3D7 chloroquine-sensitive strain using a colorimetric method. The major active compound was identified by chromatographic and spectroscopic methods. The best antiplasmodial activity was obtained for the ethyl acetate extract (15 µg/mL < IC50
      Citation: Planta Med Lett 2015; 2: e10-e11
      PubDate: 2015-03-26T09:48:45+0100
      DOI: 10.1055/s-0035-1545821
      Issue No: Vol. 2, No. 01 (2015)
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