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- Novel food drug interaction mechanism involving acyclovir, chitosan and
endogenous mucus-
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Abstract: Publication date: Available online 24 January 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Mauricio A. García, Gönül Hensler, Jozef Al-Gousous, Jonas Pielenhofer, Manfred Wagner, Hans Lennernäs, Peter Langguth
- Construction of a fused grid-based CYP2C8-Template system and the
application-
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Abstract: Publication date: Available online 20 January 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Yasushi Yamazoe, Yoshiya Yamamura, Kouichi Yoshinari
- A family study of compound variants of flavin-containing monooxygenase 3
(FMO3) in Japanese subjects found by urinary phenotyping for
trimethylaminuria-
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Abstract: Publication date: Available online 9 January 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Makiko Shimizu, Akane Yamamoto, Miaki Makiguchi, Erika Shimamura, Yuka Yokota, Mizuki Harano, Hiroshi Yamazaki
- Food effects on gastrointestinal physiology and drug absorption
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Abstract: Publication date: Available online 20 December 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Atsushi Kambayashi, Yoshiyuki Shirasaka
- Impact of P-glycoprotein on intracellular drug concentration in peripheral
blood mononuclear cells and K562 cells-
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Abstract: Publication date: Available online 16 December 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Kohei Ito, Marina Naoi, Kotaro Nishiyama, Takashi Kudo, Yasuhiro Tsuda, Caroline MacLean, Naoki Ishiguro
- High hepatic and plasma exposures of atorvastatin in subjects harboring
impaired cytochrome P450 3A4*16 modeled after virtual administrations and
possibly associated with statin intolerance found in the Japanese adverse
drug event report database-
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Abstract: Publication date: Available online 7 December 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Tasuku Sato, Norie Murayama, Makiko Shimizu, Yoshiro Saito, Hiroshi Yamazaki
- Constitutive androstane receptor-responsive elements for mouse Cyp1a2
transcriptional activation induced by constitutive androstane receptor
ligands-
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Abstract: Publication date: Available online 5 December 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Yuki Kawasaki, Nobuo Nemoto, Tsutomu Sakuma
- Construction of a fused grid-based CYP2C19-Template system and the
application-
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Abstract: Publication date: Available online 9 November 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Yoshiya Yamamura, Kouichi Yoshinari, Yasushi Yamazoe
- Comparison of human biopsy-derived and human iPS cell-derived intestinal
organoids established from a single individual-
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Abstract: Publication date: Available online 6 November 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Tatsuya Inui, Tomoki Yamashita, Junya Tomita, Jumpei Yokota, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
- Adeno-associated virus-mediated knockdown demonstrates the major role of
hepatic Bcrp in the overall disposition of the active metabolite of the
tyrosine kinase inhibitor regorafenib in mice-
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Abstract: Publication date: Available online 5 November 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Aya Hasan Alshammari, Yusuke Masuo, Shotaro Yoshino, Reiya Ymashita, Takahiro Ishimoto, Ken-ichi Fujita, Yukio Kato
- Dose optimization with population pharmacokinetics of ritonavir-boosted
lopinavir for Thai people living with HIV with and without active
tuberculosis-
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Abstract: Publication date: Available online 19 October 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Piyawat Chaivichacharn, Anchalee Avihingsanon, Sivaporn Gatechompol, Sasiwimol Ubolyam, Baralee Punyawudho
- Carboxylesterase-2 plays a critical role in dabigatran etexilate active
metabolite formation-
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Abstract: Publication date: Available online 18 October 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): S. Casey Laizure, Feng Chen, Julie E. Farrar, Dina Ali, Bing Yang, Robert B. Parker
- Associations of HLA and drug-metabolizing enzyme genes in
co-trimoxazole-induced severe cutaneous adverse reactions-
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Abstract: Publication date: Available online 18 October 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Nontaya Nakkam, Niwat Saksit, Parinya Konyoung, Warayuwadee Amornpinyo, Usanee Khunarkornsiri, Danklai Purimart, Oranuch Pattanacheewapull, Tanaporn Naewla, Pansakon Wattanachai, Kanyarat Khaeso, Pansu Chumworathayi, Wichittra Tassaneeyakul
- Effect of deuteration on the single dose pharmacokinetic properties and
postoperative analgesic activity of methadone-
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Abstract: Publication date: Available online 13 October 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Xiao-ming Wang, Jigong Wang, Valentina Fokina, Svetlana Patrikeeva, Erik Rytting, Mahmoud S. Ahmed, Jun-Ho La, Tatiana Nanovskaya
- Establishment of MDR1-knockout human enteroids for pharmaceutical
application-
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Abstract: Publication date: Available online 27 September 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Tatsuya Inui, Ryuga Nomoto, Jumpei Yokota, Tomoki Yamashita, Kentaro Okada, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
- In vitro metabolism of the new antifungal dapaconazole using
liver microsomes-
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Abstract: Publication date: Available online 20 September 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Natalícia de Jesus Antunes, Gemma Coombes, Kelly Francisco da Cunha, Fernanda de Lima Moreira, Alan C. Pilon, Norberto Peporine Lopes, José Luiz da Costa, Karin Kipper, Lewis Couchman, Atholl Johnston, Gilberto De Nucci
- Pharmacokinetics, safety, and tolerability of sodium phenylacetate and
sodium benzoate in healthy Japanese volunteers: A phase I, single-center,
open-label study-
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Abstract: Publication date: Available online 8 September 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Fumio Endo, Kimitoshi Nakamura, Yuuhei Sano, Nobuhito Dote, Kohei Shimizu, Emiko Koumura
- Drug transporters are implicated in the diffusion of tacrolimus into the T
lymphocyte in kidney and liver transplant recipients: Genetic, mRNA,
protein expression, and functionality-
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Abstract: Publication date: Available online 24 August 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Gwendal Coste, Fabien Robin, Jonathan Chemouny, Camille Tron, Jérôme Le Priol, Régis Bouvet, Marc Le Vée, Pauline Houssel-Debry, Michel Rayar, Marie-Clémence Verdier, Mikael Roussel, Marie-Dominique Galibert, Edouard Bardou-Jacquet, Olivier Fardel, Cécile Vigneau, Karim Boudjema, Bruno Laviolle, Florian Lemaitre
- A systematic study to evaluate the safety of ticagrelor combined with
aspirin in the treatment of PCI patients in Chinese population: A single
nucleotide polymorphisms study-
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Abstract: Publication date: Available online 23 August 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): ShaoJun Zheng, YiFan Xu, Qiong Jie, HuiWen Mu, Xing Zhang, JianCheng Zhu, YuBing Zhu, XiJing Chen, ShaoLiang Chen
- Comparison of the transport kinetics of fexofenadine and its pH dependency
among OATP1A2 genetic variants-
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Abstract: Publication date: Available online 22 August 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Hongye Han, Takeshi Akiyoshi, Tokio Morita, Hiroki Kataoka, Kazuhiro Katayama, Kodai Yajima, Ayuko Imaoka, Hisakazu Ohtani
- CNS penetration of methotrexate and its metabolite 7-hydroxymethotrexate
in mice bearing orthotopic Group 3 medulloblastoma tumors and model-based
simulations for children-
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Abstract: Publication date: Available online 19 August 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Rachel S. Perkins, Abigail Davis, Olivia Campagne, Thandranese S. Owens, Clinton F. Stewart
- Development of a new assay system for bladder cancer using interactions
between cytochromes P450 and serum-
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Abstract: Publication date: Available online 17 August 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Hiroki Kuwada, Kohei Ihara, Hiromasa Imaishi
- Disposition of E-selectin-targeting liposomes in tumor spheroids with a
perfusable vascular network-
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Abstract: Publication date: Available online 7 August 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Chanikarn Chantarasrivong, Ryu Okada, Yuuki Yamane, Xue Yang, Yuriko Higuchi, Miku Konishi, Naoko Komura, Hiromune Ando, Ryuji Yokokawa, Fumiyoshi Yamashita
- Formation of Reactive Metabolites of Benzbromarone in Humanized-Liver Mice
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Abstract: Publication date: Available online 5 August 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): Naoki Cho, Hiroshi Suemizu, Hidetaka Kamimura, Tomoyuki Ohe, Fumi Ito, Hidetaka Akita, Kaoru Kobayashi
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