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- Human Brain Organoids for Understanding Substance Use Disorders
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Abstract: Publication date: Available online 26 July 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Kangle Li, Longjun Gu, Hongwei Cai, Hui-Chen Lu, Ken Mackie, Feng Guo
- Clinical pharmacokinetic characteristics of Jaktinib in subjects with
hepatic impairment in a phase I trial-
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Abstract: Publication date: Available online 20 July 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Manna Zhao, Hua Zhang, Sheng Ma, Shuqing Gong, Cheng Wei, Liyan Miao, Weifeng Zhao
- Genetic variation present in the CYP3A4 gene in Ni-Vanuatu and Kenyan
populations in malaria endemicity-
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Abstract: Publication date: Available online 10 July 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Kelvin Musyoka, Chim W. Chan, Evelyn Marie Gutiérrez Rico, Protus Omondi, Caroline Kijogi, Takatsugu Okai, James Kongere, Mtakai Ngara, Wataru Kagaya, Bernard Kanoi, Masahiro Hiratsuka, Yasutoshi Kido, Jesse Gitaka, Akira Kaneko
- Characteristics of membrane transport, metabolism, and target protein
binding of cyclic depsipeptide destruxin E in HeLa cells-
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Abstract: Publication date: Available online 2 July 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Makoto Amifuji, Mai Inagaki, Masahito Yoshida, Takayuki Doi, Masanori Tachikawa
- Characterization of plasma vonoprazan and CYP3A activity using its
endogenous marker and genetic variants in patients with digestive system
disorders-
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Abstract: Publication date: Available online 2 July 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Kenta Sakaguchi, Takafumi Naito, Kohei Hoshikawa, Yukari Miyadera, Hironari Tanaka, Emi Nakatsugawa, Takahisa Furuta, Ken Sugimoto, Junichi Kawakami
- Corrigendum to “Utility of Göttingen minipigs for the prediction of
human pharmacokinetic profiles after intravenous drug administration”
[Drug Metabol Pharmacokinet 41 (2021) 100408]-
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Abstract: Publication date: August 2024Source: Drug Metabolism and Pharmacokinetics, Volume 57Author(s): Ning Ding, Syunsuke Yamamoto, Ikumi Chisaki, Miyu Nakayama, Shin-ichi Matsumoto, Hideki Hirabayashi
- Iminium ion metabolites are formed from nintedanib by human CYP3A4
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Abstract: Publication date: Available online 10 June 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Shimon Nakashima, Tatsuki Fukami, Takashi Kudo, Masataka Nakano, Akiko Matsui, Naoki Ishiguro, Miki Nakajima
- Preface: In silico technologies
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Abstract: Publication date: Available online 31 May 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Kazuya Maeda, Masayo Oishi
- Population pharmacokinetic analysis of sirolimus in Japanese pediatric and
adult subjects receiving tablet or granule formulations-
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Abstract: Publication date: Available online 31 May 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Taichi Miyazaki, Daichi Hayashi, Akifumi Nozawa, Shiho Yasue, Saori Endo, Hidenori Ohnishi, Ryuta Asada, Mototoshi Kato, Akihiro Fujino, Tatsuo Kuroda, Takanobu Maekawa, Shigehisa Fumino, Naonori Kawakubo, Tatsuro Tajiri, Kenji Shimizu, Chihiro Sanada, Izumi Hamada, Yuko Ishikawa, Mayumi Hasegawa, Kashyap Patel
- Physiologically Based Pharmacokinetic modeling of CYP2C8 substrate
rosiglitazone and its metabolite to predict metabolic drug-drug
interaction-
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Abstract: Publication date: Available online 28 May 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Nilesh Gaud, Dawid Gogola, Anna Kowal-Chwast, Ewelina Gabor-Worwa, Peter Littlewood, Krzysztof Brzózka, Kamil Kus, Maria Walczak
- Insights into Drug Development with Quantitative Systems Pharmacology: A
Prospective Case Study of Uncovering Hyperkalemia Risk in Diabetic
Nephropathy with Virtual Clinical Trials-
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Abstract: Publication date: Available online 9 May 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Ryuta Saito, Tomohisa Nakada
- Practical QSP application from the preclinical phase to enhance the
probability of clinical success: Insights from case studies in oncology-
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Abstract: Publication date: Available online 9 May 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Masayo Oishi, Hiroyuki Sayama, Kota Toshimoto, Takeshi Nakayama, Yasuhisa Nagasaka
- Beyond the basics: A deep dive into parameter estimation for advanced PBPK
and QSP models-
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Abstract: Publication date: Available online 26 March 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Kota Toshimoto
- Population pharmacokinetics of everolimus in renal transplant recipients
receiving long-term multiple immunosuppressive therapy-
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Abstract: Publication date: Available online 12 March 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Tomoyuki Sakaue, Kazuhiro Yamamoto, Kotaro Itohara, Yumi Kitahiro, Takahito Endo, Naoki Yokoyama, Takeshi Ishimura, Tomohiro Omura, Ikuko Yano
- Prediction of drug-drug interaction risk of P-glycoprotein substrate in
drug discovery-
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Abstract: Publication date: Available online 11 March 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Yasuto Kido, Isamu Nanchi, Takanobu Matsuzaki, Ryosuke Watari, Hayato Kiyohara, Naomi Seki, Tomohiko Okuda
- Quantitative prediction of CYP3A induction-mediated drug-drug interactions
in clinical practice-
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Abstract: Publication date: Available online 11 March 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Haruka Tsutsui, Motohiro Kato, Shino Kuramoto, Kouichi Yoshinari
- Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase
on drug hydrolysis and lipid accumulation-
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Abstract: Publication date: Available online 6 March 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Yoshiyuki Sakai, Tatsuki Fukami, Shinsaku Tokumitsu, Masataka Nakano, Shimon Nakashima, Yuichiro Higuchi, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu, Miki Nakajima
- In vitro demonstration of antedrug mechanism of a pharmacokinetic booster
to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition-
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Abstract: Publication date: Available online 2 March 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Makoto Kataoka, Sae Takenaka, Shota Fujii, Takato Masada, Keiko Minami, Toshihide Takagi, Masaaki Omote, Kentaro Kawai, Shinji Yamashita
- Application of machine learning techniques in population
pharmacokinetics/pharmacodynamics modeling-
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Abstract: Publication date: Available online 17 February 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Mizuki Uno, Yuta Nakamaru, Fumiyoshi Yamashita
- DMPK perspective on quantitative model analysis for chimeric antigen
receptor cell therapy: Advances and challenges-
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Abstract: Publication date: Available online 14 February 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Akihiko Goto, Yuu Moriya, Miyu Nakayama, Shinji Iwasaki, Syunsuke Yamamoto
- Unveiling the intra-tumor fate of trastuzumab deruxtecan in a xenograft
model to support its mechanism of action-
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Abstract: Publication date: Available online 23 January 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Yoko Nagai, Masataka Oitate, Takahiro Shibayama, Hideo Takakusa, Nobuaki Watanabe
- Predicting muscarinic receptor occupancy in human bladder mucosa from
urinary concentrations of antimuscarinic agents for overactive bladder-
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Abstract: Publication date: Available online 15 January 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Mizuki Shiho, Gaku Akashita, Eriko Nakatani, Shimako Tanaka, Shizuo Yamada, Takashi Okura
- Applications of model simulation in pharmacological fields and the
problems of theoretical reliability-
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Abstract: Publication date: Available online 4 January 2024Source: Drug Metabolism and PharmacokineticsAuthor(s): Yoshiaki Kariya, Masashi Honma
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