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- Population pharmacokinetic modeling of treosulfan and rationale for dose
recommendation in children treated for conditioning prior to allogeneic
hematopoietic stem cell transplantation-
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Abstract: Publication date: Available online 30 May 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Xieran Li, Krzysztof Kalwak, Rita Beier, Jochen Kehne, Ann-Kristin Möller, Joachim Baumgart, Dietrich W. Beelen, Ralf A. Hilger, Ajay Vora, Karl-Walter Sykora
- Contribution analysis of metabolic tissues on systemic exposure of an
active metabolite after oral administration of verapamil using a stable
isotope-labeled compound-
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Abstract: Publication date: Available online 19 May 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Makoto Kataoka, Shota Ohshiro, Keiko Minami, Tsubasa Hasegawa, Haruki Higashino, Toshihide Takagi, Kazutaka Togashi, Kuninori Mutaguchi, Shinji Yamashita
- New in vitro screening system to detect drug-induced liver injury using a
culture plate with low drug sorption and high oxygen permeability-
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Abstract: Publication date: Available online 26 April 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Akinori Takemura, Sanae Ishii, Yugo Ikeyama, Katsuhiro Esashika, Jun Takahashi, Kousei Ito
- Apple-derived extracellular vesicles modulate the expression of human
intestinal bile acid transporter ASBT/SLC10A2 via downregulation of
transcription factor RARα-
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Abstract: Publication date: Available online 25 April 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Shinya Usui, Qiunan Zhu, Hisakazu Komori, Yui Iwamoto, Takumi Nishiuchi, Yoshiyuki Shirasaka, Ikumi Tamai
- Characterization of LysoTracker Red uptake by in vitro model cells of the
outer blood-retinal barrier: Implication of lysosomal trapping with
cytoplasmic vacuolation and cytotoxicity-
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Abstract: Publication date: Available online 23 April 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Yuma Tega, Toshinari Takeuchi, Masatoshi Nagano, Reina Makino, Yoshiyuki Kubo, Shin-ichi Akanuma, Ken-ichi Hosoya
- Development of a fluorescent-labeled trapping reagent to evaluate the risk
posed by acyl-CoA conjugates-
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Abstract: Publication date: Available online 10 April 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Chikako Shibazaki, Tadahiko Mashino, Tomoyuki Ohe
- Corrigendum to
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Abstract: Publication date: Available online 1 April 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Ning Ding, Syunsuke Yamamoto, Ikumi Chisaki, Miyu Nakayama, Shin-ichi Matsumoto, Hideki Hirabayashi
- Ferulic acid prevents Diosbulbin B-induced liver injury by inhibiting
covalent modifications on proteins-
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Abstract: Publication date: Available online 30 March 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Huiling Chen, Chenchen Liu, Meng Li, Yida Zhang, Zhendong Wang, Qiyao Jiang, Jianxin Wang, Qi Wang, Yue Zhuo
- Physiologically based pharmacokinetic (PBPK) model that describes enhanced
FcRn-dependent distribution of monoclonal antibodies (mAbs) by
pI-engineering in mice-
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Abstract: Publication date: Available online 22 March 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Sotaro Naoi, Mizuki Yamane, Takayuki Nemoto, Motohiro Kato, Ryoichi Saito, Tatsuhiko Tachibana
- Evaluation and prediction of oral drug absorption and bioequivalence with
food-drug interaction-
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Abstract: Publication date: Available online 6 March 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Yasuhiro Tsume
- Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation
mediated by liver microsomes and humanized liver in chimeric mice
metabolically suppressed with azamulin-
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Abstract: Publication date: Available online 6 March 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Shotaro Uehara, Makiko Shimizu, Hiroshi Suemizu, Hiroshi Yamazaki
- A novel method for predicting the unbound valproic acid concentration
-
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Abstract: Publication date: Available online 5 March 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Masayuki Ishikawa, Masashi Uchida, Takahiro Asakawa, Shota Suzuki, Shingo Yamazaki, Yuki Shiko, Yohei Kawasaki, Takaaki Suzuki, Itsuko Ishii
- Black ginger extract and its active compound, 5,7-dimethoxyflavone,
increase intestinal drug absorption via efflux drug transporter
inhibitions-
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Abstract: Publication date: Available online 28 February 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Rattiporn Boonnop, Paranee Meetam, Lawan Siangjong, Patoomrat Tuchinda, Piyanut Thongphasuk, Sunhapas Soodvilai, Sirima Soodvilai
- Physiological effects of food ingredients on intestinal epithelial cell
function-
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Abstract: Publication date: Available online 25 February 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Hideo Satsu, Shimon Kimura, Yuki Hori
- Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1
and CES using the PITCh system-
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Abstract: Publication date: Available online 18 February 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Naoki Yamada, Ryosuke Negoro, Keita Watanabe, Takuya Fujita
- Involvement of multiple cytochrome P450 isoenzymes in drug interactions
between ritonavir and direct oral anticoagulants-
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Abstract: Publication date: Available online 18 February 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Yuta Tamemoto, Yukihiro Shibata, Natsumi Hashimoto, Hiromi Sato, Akihiro Hisaka
- Population pharmacokinetics of duloxetine in Japanese pediatric patients
with major depressive disorder-
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Abstract: Publication date: Available online 15 February 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Risa Yokokawa Shibata, Ryuji Kubota, Kazunori Uenaka, Atsunori Kaibara, Toshihiro Wajima
- Effect of antibiotic-administration period on hepatic bile acid profile
and expression of pharmacokinetic-related proteins in mouse liver, kidney,
and brain capillaries-
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Abstract: Publication date: Available online 9 February 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Ryotaro Yagi, Takeshi Masuda, Shingo Ito, Sumio Ohtsuki
- Bioavailability of tetracyclines is substantially increased by
administration of cyclosporine A, a non-specific efflux-pump blocker-
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Abstract: Publication date: Available online 4 February 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Hubert Ziółkowski
- Construction of a fused grid-based CYP2C8-Template system and the
application-
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Abstract: Publication date: Available online 20 January 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Yasushi Yamazoe, Yoshiya Yamamura, Kouichi Yoshinari
- A family study of compound variants of flavin-containing monooxygenase 3
(FMO3) in Japanese subjects found by urinary phenotyping for
trimethylaminuria-
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Abstract: Publication date: Available online 9 January 2023Source: Drug Metabolism and PharmacokineticsAuthor(s): Makiko Shimizu, Akane Yamamoto, Miaki Makiguchi, Erika Shimamura, Yuka Yokota, Mizuki Harano, Hiroshi Yamazaki
- A systematic study to evaluate the safety of ticagrelor combined with
aspirin in the treatment of PCI patients in Chinese population: A single
nucleotide polymorphisms study-
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Abstract: Publication date: Available online 23 August 2022Source: Drug Metabolism and PharmacokineticsAuthor(s): ShaoJun Zheng, YiFan Xu, Qiong Jie, HuiWen Mu, Xing Zhang, JianCheng Zhu, YuBing Zhu, XiJing Chen, ShaoLiang Chen
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