A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  

  First | 1 2 3        [Sort alphabetically]   [Restore default list]

  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted by number of followers
Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 11)
Pharmazeutische Industrie     Full-text available via subscription   (Followers: 9)
Pharmaceutical Fronts     Open Access   (Followers: 8)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Pharmaceutical Journal     Free   (Followers: 8)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 6)
Molekul     Open Access   (Followers: 5)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 5)
AAPS Open     Open Access   (Followers: 5)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Journal of Drug Delivery Science and Technology     Hybrid Journal   (Followers: 3)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Canadian Journal of Pain     Open Access   (Followers: 3)
PharmaNutrition     Hybrid Journal   (Followers: 3)
Journal of Pharmacological Sciences     Open Access   (Followers: 3)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
Indian Journal of Drugs in Dermatology     Open Access   (Followers: 2)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Journal of Education and Science     Open Access   (Followers: 2)
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Current Research in Drug Discovery     Open Access   (Followers: 2)
International Journal of Immunopathology and Pharmacology     Open Access   (Followers: 2)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Journal of Pharmaceutical Sciences and Pharmacology     Full-text available via subscription   (Followers: 2)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Journal of Applied Pharmaceutical Research     Open Access   (Followers: 1)
Integrative Medicine International     Open Access   (Followers: 1)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Separation Science plus (SSC plus)     Hybrid Journal   (Followers: 1)
Open Pharmacoeconomics & Health Economics Journal     Open Access   (Followers: 1)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
Journal of the American College of Clinical Pharmacy : JACCP     Hybrid Journal   (Followers: 1)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Pharmactuel     Open Access   (Followers: 1)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Journal of Metabolomics & Systems Biology     Open Access   (Followers: 1)
Journal of Pharmaceutical Technology, Research and Management     Open Access   (Followers: 1)
Farmakoèkonomika : Modern Pharmacoeconomic and Pharmacoepidemiology     Open Access   (Followers: 1)
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian     Open Access   (Followers: 1)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 1)
Expert Review of Precision Medicine and Drug Development     Hybrid Journal   (Followers: 1)
OpenNano     Open Access   (Followers: 1)
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 1)
Journal of Biopharmaceutics Sciences     Open Access   (Followers: 1)
Pediatric Pharmacology     Open Access   (Followers: 1)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
Journal of Pharmaceutical Health Care and Sciences     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
Medicines     Open Access   (Followers: 1)
Future Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Pharmacy & Pharmacology     Open Access   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Pharmacological Research - Modern Chinese Medicine     Open Access  
Clinical Complementary Medicine and Pharmacology     Open Access  
Exploratory Research in Clinical and Social Pharmacy     Open Access  
Indonesian Journal of Pharmaceutical Education     Open Access  
Future Drug Discovery     Open Access  
IUPHAR/BPS Guide to Pharmacology CITE     Open Access  
Journal of Applied Pharmaceutical Sciences and Research     Open Access  
Cephalalgia Reports     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacia     Open Access  
Research Results in Pharmacology     Open Access  
Journal of Toxins     Open Access  
Journal of Pharmaceutics & Pharmacology     Open Access  
Natural Product Communications     Open Access  
PharmaTutor     Open Access  
International Journal of Pharmaceutical Sciences and Developmental Research     Open Access  
Toxicological Research     Hybrid Journal  
Current Medical Science     Hybrid Journal  
EUREKA : Health Sciences     Open Access  
Iraqi Journal of Pharmacy     Open Access  
Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Medicine in Drug Discovery     Open Access  
Frontiers in Medical Technology     Open Access  
International Journal of Medical and Pharmaceutical Case Reports     Open Access  
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
Journal of Pharmaceutical Health Services Research     Hybrid Journal  
AboutOpen     Open Access  
Current Protocols in Pharmacology     Hybrid Journal  
Medical Cannabis and Cannabinoids     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Pharmaceutical Journal of Sri Lanka     Open Access  
Isan Journal of Pharmaceutical Sciences (IJPS)     Open Access  
Ciencia e Investigación     Open Access  
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community)     Open Access  
Toxicon : X     Open Access  
International Journal of Pharmaceutics: X     Open Access  
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia     Open Access  
Open Pharmacology Journal     Open Access  
ExRNA     Open Access  
International Journal of Pharmaceutics & Pharmacology     Open Access  
Antibody Therapeutics     Open Access  
Journal of Faculty of Pharmacy of Ankara University     Open Access  
Iraqi Journal of Pharmaceutical Sciences     Open Access  
Journal of Medicinal Botany     Open Access  
Journal of Medicinal Herbs and Ethnomedicine     Open Access  
International Journal of Pharmacokinetics     Hybrid Journal  
Neuropsychopharmacology Reports     Open Access  
Reviews on Clinical Pharmacology and Drug Therapy     Full-text available via subscription  
SynOpen     Open Access  
Matrix Science Pharma     Open Access  
Contract Pharma     Full-text available via subscription  
Journal of Cellular Neuroscience and Oxidative Stress     Open Access  
Istanbul Journal of Pharmacy     Open Access  
Acta Pharmaceutica Indonesia     Open Access  
Indonesian Journal of Pharmacy     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
High-Throughput     Open Access  
Scientia Pharmaceutica     Open Access  
Trends in Peptide and Protein Sciences     Open Access  
Acta Physiologica Hungarica     Full-text available via subscription  
Jurnal Farmasi Sains dan Praktis     Open Access  
Jurnal Kefarmasian Indonesia     Open Access  
Pharmaceutical Historian     Open Access  
Planta Medica International Open     Open Access  
Archives of Razi Institute     Open Access  
Journal of Pharmaceutical Research     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
FarmaJournal     Open Access  
Journal of Negative and No Positive Results     Open Access  
Pharmaciana     Open Access  
Folia Medica Indonesiana     Open Access  
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
International Journal of Pharmacology, Phytochemistry and Ethnomedicine     Open Access  
Фармацевтичний часопис     Open Access  
Ciência Equatorial     Open Access  
Iranian Journal of Pharmaceutical Research     Open Access  
Research & Reviews : A Journal of Drug Design & Discovery     Full-text available via subscription  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Research & Reviews : A Journal of Pharmacognosy     Full-text available via subscription  
Ars Pharmaceutica     Open Access  
Pharmacognosy Communications     Partially Free  
Egyptian Pharmaceutical Journal     Open Access  
Pharmacological Reports     Hybrid Journal  
PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Journal of Nanopharmaceutics and Drug Delivery     Full-text available via subscription  
Journal of Hydrogels     Full-text available via subscription  
Manufacturing Chemist     Full-text available via subscription  
Pharmaceutica Analytica Acta     Open Access  
Journal of Pharmacovigilance     Open Access  
Current Pharmacology Reports     Hybrid Journal  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
International Journal of Herbs and Pharmacological Research     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Research Journal of Pharmacognosy     Open Access  

  First | 1 2 3        [Sort alphabetically]   [Restore default list]

Similar Journals
Journal Cover
Nigerian Journal of Natural Products and Medicine
Number of Followers: 0  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1118-6267
Published by African Journals Online Homepage  [261 journals]
  • Plausible causes of low incidence of COVID 19 in Tropical Africa: A review

    • Free pre-print version: Loading...

      Authors: Joseph M. Agbedahunsi
      Pages: 24 - 33
      Abstract: No Abstract.
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.1
      Issue No: Vol. 25, No. 1 (2021)
       
  • Investigation on the antimalarial properties of Plumeria alba Linn
           (apocynaceae) cultivated in Nigeria

    • Free pre-print version: Loading...

      Authors: S.A. Adesida, S.A. Odediran , A.A. Elujoba
      Pages: 34 - 42
      Abstract: Many of the African antimalarial ethno medicinal plants are good sources of promising antimalarial compounds. The stem bark of Plumeria alba Linn, was evaluated for in vivo chemosuppressive antimalarial activities in order to identify the most active solvent  fraction from which antimalarial constituents can be isolated. The stem-bark of Plumeria alba Linn, family Apocynaceae was   collected, air-dried, powdered, macerated in methanol and the extract concentrated in vacuo. The acute toxicity study was   performed on the extract using Lorke’s method. The extract was thereafter tested for chemosuppressive antiplasmodial activities against Plasmodium berghei berghei NK65- infected mice using Peter’s four-day test at doses 100-800 mg /kg with normal saline (0.2 ml) and chloroquine (10 mg/kg) as negative and positive control drugs respectively. The average percentage parasitaemia, percentage chemosuppression and effective doses (ED50 and ED90), the survival times and percentage survivors elicited in all the  mice were  determined as indices of antimalarial activity. The active extract was  subsequently partitioned successively into n-hexane, dichloromethane, ethyl acetate and butanol. The respective partitioned fractions with the aqueous phase were also tested as above at doses 0-80 mg/kg. All results were  subjected to statistical analysis using ANOVA with Student Newman Keul’s post hoc test. Crude extracts of P. alba gave considerable reduction of percentage parasitaemia up to 200 mg/kg. The percentage  chemosuppression at all doses, were significantly higher (p<0.05) than the negative but lower than the positive control with 200 mg/kg dose showing the highest activity of 65.88 %. The effective doses, ED50 and ED90 were  305.82±9.99 and 389.74± 9.60, respectively. The most active n-hexane partitioned fraction elicited a percentage chemosuppression of 67.75 and a significantly lower (p<0.05) ED50 and ED90 of 31.27±0.85 and 54.80±1.75 mg/kg. The butanol and ethyl acetate partitioned fractions gave significantly higher (p<0.05) survival time value than those of the crude extract, other partition fractions and the positive control, while the n-hexane, dichloromethane and the aqueous, just like chloroquine, gave high percentage survivors. The study concluded that Plumeria alba stem-bark extract was active as an antimalarial drug with its antiplasmodial and the survival time–enhancing activity concentrated in the n-hexane and ethyl acetate with butanol partitioned fractions respectively, thus confirming and justifying its ethnomedical application in malaria.
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.2
      Issue No: Vol. 25, No. 1 (2021)
       
  • Antibacterial activity of Urena lobata against
           uropathogens

    • Free pre-print version: Loading...

      Authors: Taofeeq Garuba, Nency Katrodiya, Nikita Patel, Swetal Patel, Dhanji. P. Rajani, Shiva Shankaran Chettiar, A.A. AbdulRahman, R. Krishnamurthy
      Pages: 43 - 46
      Abstract: Urinary tract infections (UTI) are one of the most common form of bacterial infections but the treatment becomes cumbersome as the etiological bacteria are developing resistance against antibiotics. This present study evaluated the efficacy of antimicrobial   activity of Urena lobata against uropathogens. Six urine samples from UTI patients were collected from Pathological Laboratory, G.B. Vaghani Multispecialty Hospital, Surat. Bacteria were isolated from these samples using Nutrient agar, Mac Conkey agar plate, Blood agar, Mannitol salt agar, Eosin Methylene Blue agar and King’s agar. The bacterial isolates were identified using cultural  characteristics, microscopic features and biochemical characteristics. Leaf extract of Urena lobata was prepared using Soxhlet Extraction Method whereby methanol and distilled water were the extractants used. Herbal extract disc was prepared at  concentrations of 50,75, and100 mg/ml and tested against all the isolates. DMSO and antibiotics (Nitrofurantion, Amikacin, Levofloxacin, Norofloxacin, Ofloxacin and Cephalosporins) were used as negative and positive controls respectively.Staphylococcus aureus, Escherichia coli, Bacillus cereus, Streptococcus pneumoniae, Klebsiella spp. and Brevibacillus panacihumi were isolated from the urine samples. All concentrations of aqueous and methanolic extracts of U. lobata leaf displayed highest zone of inhibition against B. cereus. No inhibitory effect was observed against the growth of Klebsiella except at the highest concentrations. Further study is encouraged on the in-vivo study of efficacy of U. lobata on etiological agent of UTI.
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.3
      Issue No: Vol. 25, No. 1 (2021)
       
  • A focus on biometal systems of some phyto-antibiotic drug complexes

    • Free pre-print version: Loading...

      Authors: Saliu A. Amolegbe, Kehinde T. Kareem, Caroline A. Akinremi, aMikhail O. Nafiu, Oluseyi A. Akinloye
      Pages: 47 - 68
      Abstract: Biometal coordination bearing active donor atoms of medicinal plant extracts or herbal isolates (phytochemicals) in the recent approach of biomedical sciences is a new and advanced chemotherapeutics for combating antibiotics resistance. Stereochemistry of central metal ions around active plant molecules can give rise to robust solid state 3D metal complexes of antibiotics aiding better biological performance/affinity without any side effect compared with the parent biomolecules (organic ligands). This review therefore focuses on the applications of medicinal plant extracts as antibiotics. Structural systems of metal complexes of flavonoids, curcumins, alkaloids, carotenoids and coumarins from aloe vera, acalypha and henna leaf (AAH) are also described with a view to achieving the rationale for functional bioactive antibiotic drugs
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.4
      Issue No: Vol. 25, No. 1 (2021)
       
  • Chemical composition and anticancer effects of Zingiber
           officinale
    volatile oil

    • Free pre-print version: Loading...

      Authors: R.O. Imade , B.A. Ayinde , M.I. Choudhary , A. Alam
      Pages: 60 - 63
      Abstract: Zingiber officinale rhizome is used in ethnomedicine in treating tumor-related ailments. This study was undertaken to evaluate the cytotoxic effects of this plant. The oil was extracted using a Clavenger apparatus by hydro-distillation method. Preliminary screening was carried out with brine shrimp cytotoxicity test at 10-1000 µg/mL. The volatile oil was further tested on breast cancer (AU 565) and cervical cancer (HeLa) at 50 µg /mL using MTT assay and later subjected to GCMS analysis. LC50 of 157.75 µg/mL was obtained in the brine shrimp mortality assay. Z. officinale oil showed high anticancer activities with 50 and 43 % inhibitions against HeLa and AU 565 cells respectively. GCMS analysis revealed the major constituents of Z. officinale oil as a-citral (11.68 %) and a-citral (10.18 %). These results suggest the medicinal potency of this plant oil.
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.5
      Issue No: Vol. 25, No. 1 (2021)
       
  • Chemical composition and anticancer effects of Hyptis Suaveolens L. Poit
           (lamiaceae) volatile oil

    • Free pre-print version: Loading...

      Authors: R.O. Imade, B.A. Ayinde, M.I. Choudhary, A. Alam
      Pages: 64 - 69
      Abstract: The leaf of Hyptis suaveolens have found application in ethnomedicine in the treatment of various ailments including those that are related to tumor and cancer. This study was therefore undertaken to evaluate the cytotoxic effects of its volatile oil. Volatile oil distilled from freshly collected leaves using a Clavenger-type apparatus was screened using tadpoles of Raniceps ranninus (10-40 µg/mL) and brine shrimp of Artemia salina (10-1000 µg/mL) with bench-top assay procedures for cytotoxicity while growth inhibitory activity was assessed using radicles of Sorghum bicolor seeds (1-30 mg/mL). The essential oils were further tested on breast cancer (AU 565) and cervical cancer (HeLa) at 50 µg /mL using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay and afterwards subjected to Gas Chromatography Mass Spectrometric (GCMS) analysis for its constituents. An LC50 of 188.67 and 8 µg/mL were obtained in the brine shrimp mortality and tadpole lethality assays respectively. The oil showed inhibitions of 86.74 and 21.8 % against AU 565 and HeLa cells respectively. GCMS analysis revealed the major constituents as sabinene (10.64 %) and (-)-4-terpineol (7.27 %). These results support its use in treating tumor-related ailments and should be considered for further studies.
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.6
      Issue No: Vol. 25, No. 1 (2021)
       
  • Correlation between tumor markers in pre and post treatment of pancreatic
           cancer patients

    • Free pre-print version: Loading...

      Authors: N. Sivakumar, R. Arivazhagan, B. Prabasheela
      Pages: 70 - 74
      Abstract: One of the main causes of death in India is pancreas cancer. Various blood tumour indicators such as 19-9 carbohydrate antigen (CA19-9), antigen125 carbohydrate (CA125), antigen carcinoembryogenic (CEA) and alphaetoprotein (AFP) imbalance are observed in therapy for cancer. In disease predictions, thorough monitoring of the change in serum tumour markers was highly essential. The present investigation was thus conducted to examine serum marker tumour profiles before and after therapy of individuals with pancreatic cancer. The study comprised 400 individuals from both sexes suffering from pancreatic carcinogenic malignancy. In the pre and post-treatment of patients we detected serum tumour markers. In post-treatment groups, serum tumour marker levels were lower than before the individuals were treated. However, using pairs of samples t-testing at pfleg.0.05 these changes were statistically significant. Marker alterations in the serum tumour have shown risk for individuals. These alterations therefore enable the cancer individuals to predict and monitor properly.
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.7
      Issue No: Vol. 25, No. 1 (2021)
       
  • In vitro antioxidant activity and phytochemical analyses of Acalypha
           godseffiana (Euphobiaceae) leaf extracts

    • Free pre-print version: Loading...

      Authors: S.O. Olubodun, G.E. Eriyamremu, M.E. Ayevbuomwan, C.I. Nzoputa
      Pages: 75 - 79
      Abstract: The presence of various bioactive components makes it necessary to analyse plants for their potential to act as a source of useful treatments and cures for many inflammatory, infectious and pathogenic diseases. This study was carried out to determine phytochemicals and in-vitro antioxidant activities of the leaf extracts of Acalypha godseffiana. The leaves of A. godseffiana were collected, dried, pulverized and extracted separately with methanol and water using maceration method. The extract was concentrated in vacuo with rotary evaporator at 40oC. The extracts were subjected to quantitative phytochemical analysis and different anti-oxidant analytical procedures like FRAP, DPPH etc to determine the radical scavenging capabilities. The results of phytochemical analysis estimated the quantities and revealed the presence of alkaloids, flavonoids, tannins, saponins and terpenoids which varied in both extracts. The methanol and aqueous extracts exhibited antioxidant activities with relatively high IC50 (IC50 = 3.67 ìg/ml and 4.42ìg/ml respectively) which accounted for a low free radical-scavenging activity when compared with the reference antioxidant, vitamin C (IC50 = 1.51ìg/ml). The results of the study indicates that A. godseffiana leaf extracts contain secondary metabolites and possesses antioxidant properties.
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.8
      Issue No: Vol. 25, No. 1 (2021)
       
  • Bioassay-guided isolation of cytotoxic constituents of Aframomum melegueta
           K.Schum. seeds

    • Free pre-print version: Loading...

      Authors: Owoola Azeezat Ambali, Samuel Ayoolu Oguntimehin, Edith Oriabure Ajaiyeoba, Omonike Oluyemisi Ogbole, Adekunle Johnson Adeniji
      Pages: 80 - 85
      Abstract: The seeds of Aframomum melegueta are used extensively in the Nigerian ethnomedicine for the management of cancer. This study therefore aimed at isolating and characterizing its cytotoxic constituents. Methanol extract of the seed was obtained through cold maceration, and it was further partitioned into n – hexane, dichloromethane and ethylacetate. The most active fraction was purified on repeated chromatographic techniques, using vacuum liquid chromatography (VLC), column (CC), and high-performance liquid chromatography (HPLC). The extract, purified fractions and isolated compounds were tested for their cytotoxic activities against the human Rhabdomyosarcoma (RD) and breast (MCF-7) cancer cell lines, using MTT assay. The crude extract and n-hexane fraction were found to be selectively cytotoxic to the cancer cell lines. Bioassay-guided fractionation of the n-hexane fraction led to the isolation of three compounds, which were identified as 6-shogaoal, 6-paradol, and 1-dehydro-6-gingerdione.  6-shogaoal   demonstrated the highest cytotoxicity with CC50 values of 0.11 ± 0.02 and 0.25 ± 0.05ìg/mL against RD and MCF-7 cell lines  respectively, and these were higher in activity when compared with cyclophosphamide (CC50 = 1.98 ± 0.15 and 0.71 ± 0.7ìg/mL). The presented data validates the  ethnomedicinal use of A. melegueta in the treatment of cancer and is also indicative of the potential of 6-shogaol as an anticancer agent.
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.9
      Issue No: Vol. 25, No. 1 (2021)
       
  • Isolation of the antidiarrhoeal tiliroside and its derivative from
           Waltheria indica leaf extract

    • Free pre-print version: Loading...

      Authors: B.A. Ayinde, J.O. Owolabi, I.S. Uti, P.C. Ogbeta, M.I. Choudhary
      Pages: 86 - 92
      Abstract: The antidiarrhoeal effect of Waltheria indica methanol extract and fractions have been reported earlier but, the present work examined the intestinal relaxant effects of two flavonoid-phenyl propanoids isolated from the methanol extract. The active aqueous fraction was subjected to vacuum liquid chromatography using dichloromethane with increasing concentration of ethyl acetate, and that of methanol and water successively. The ten (10) fractions obtained were combined to give seven (7). The fraction 2 (C, D) was subjected to preparative thin layer chromatography on silica gel GF254 (10-40μm) using CHCl3-CH3OH (8:2) to obtain compound coded F2. Fraction 4 (F) was subjected to column chromatography using silica gel (60-120μm mesh) and eluted with  dichloromethane with increasing concentrations of methanol. Fractions 9-28 were combined and subjected to column  chromatography using chloroform with increasing concentration of methanol. The fractions 1-16 of these were purified on Sephadex LH-20 to obtain compound BAA. The identities of the two compounds were established using spectroscopic methods. The  antidiarrheal effect of compound F2 was evaluated on mice using charcoal transit (100,200, 400mg/kg), castor oil (40, 60 mg/kg)  while the two compounds were examined for their inhibitory effects on Ach-induced ileum contraction. The effects of the  compounds were compared with loperamide (3mg/kg) and atropine (80μg). Compounds F2 and BAA were identified as tiliroside and 3’’’, 5’’’-dimethoxy tiliroside respectively. Tiliroside inhibited the charcoal transition in the animals in a dose dependent pattern with 400mg/ mL eliciting 63.41% inhibition compared to 59.23% produced by loperamide. The compound also elicited significantly (P<0.05) prolonged onset of stooling and reduced the number and weight of stools produced lower than the control. The two  compounds drastically inhibited the Ach-induced contractions of the ileum. The compound, tiliroside at 10mg, completely abolished  the contraction by Ach unlike 3’’’, 5’’’-dimethoxy tiliroside which reduced the contraction to 1.92% at 20mg. The identified compounds seem to be responsible for the ethnomedicinal use of the plant in treating diarrhea.
      PubDate: 2021-10-12
      DOI: 10.4314/njnpm.v25i1.10
      Issue No: Vol. 25, No. 1 (2021)
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 18.232.56.9
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-