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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 27)
AAPS Open     Open Access   (Followers: 5)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 2)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 92)
Advanced Herbal Medicine     Open Access   (Followers: 10)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 13)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 8)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 5)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 4)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 11)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 6)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 6)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 20)
American Journal of Drug Discovery and Development     Open Access   (Followers: 2)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 51)
American Journal of Pharmacological Sciences     Open Access   (Followers: 2)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 21)
American Journal of Therapeutics     Hybrid Journal   (Followers: 11)
Analytical Methods     Hybrid Journal   (Followers: 7)
Annales Pharmaceutiques Francaises     Full-text available via subscription  
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 51)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 26)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 6)
Antibiotics     Open Access   (Followers: 12)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 7)
Applied Clinical Trials     Full-text available via subscription   (Followers: 5)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 1)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Archives of Razi Institute     Open Access   (Followers: 1)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Pharmaceutics     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Pharmaceutical Journal     Full-text available via subscription  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 11)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Bioanalysis     Full-text available via subscription   (Followers: 6)
Biochemical Pharmacology     Hybrid Journal   (Followers: 9)
BioDrugs     Full-text available via subscription   (Followers: 4)
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 1)
Biomarkers in Drug Development     Partially Free   (Followers: 1)
Biomaterials     Hybrid Journal   (Followers: 54)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 1)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 6)
Biopharm International     Full-text available via subscription   (Followers: 8)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 11)
BMC Pharmacology     Open Access   (Followers: 3)
BMC Pharmacology & Toxicology     Open Access   (Followers: 5)
Brazilian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 25)
British Journal of Pharmacology     Hybrid Journal   (Followers: 14)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 1)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 12)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical and Pharmaceutical Bulletin     Full-text available via subscription  
Chemical Research in Toxicology     Hybrid Journal   (Followers: 20)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Ciencia e Investigación     Open Access  
Ciência Equatorial     Open Access  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 3)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access   (Followers: 2)
Clinical Drug Investigation     Full-text available via subscription   (Followers: 6)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 11)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 16)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 31)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 2)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 5)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 5)
Clinical Therapeutics     Hybrid Journal   (Followers: 10)
Clinical Toxicology     Hybrid Journal   (Followers: 17)
Clinical Trials     Hybrid Journal   (Followers: 12)
CNS Drug Reviews     Open Access   (Followers: 3)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 6)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Therapeutic Drug Carrier Systems     Full-text available via subscription  
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 22)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 3)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 5)
Current Drug Metabolism     Hybrid Journal   (Followers: 3)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 2)
Current Drug Therapy     Hybrid Journal   (Followers: 2)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 7)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 4)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 1)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 5)
Current Therapeutic Research     Open Access   (Followers: 5)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 7)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 1)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 3)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 12)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 7)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 1)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 24)
Drug Development Research     Hybrid Journal   (Followers: 8)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 7)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 8)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 3)
Drug Metabolism Letters     Hybrid Journal   (Followers: 2)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 3)
Drug Research     Hybrid Journal   (Followers: 1)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 78)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 8)
Drugs     Full-text available via subscription   (Followers: 139)
Drugs & Aging     Full-text available via subscription   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs and Therapy Studies     Open Access  
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 4)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Egyptian Pharmaceutical Journal     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 2)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 7)
Epilepsy Research     Hybrid Journal   (Followers: 8)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 11)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 5)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 82)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 23)
European Journal of Pharmacology     Hybrid Journal   (Followers: 3)
European Medical, Health and Pharmaceutical Journal     Open Access   (Followers: 2)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 8)
European Pharmaceutical Journal     Open Access  

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Ethiopian Pharmaceutical Journal
Number of Followers: 1  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1029-5933
Published by African Journals Online Homepage  [260 journals]
  • Toxic Effects of 70% Ethanol Moringa stenopetala (Baker f.) Cufod.
           (Moringaceae) Leaf Extract on Wistar Albino Rat Embryos

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      Authors: Hussen Abdu, Wondwosen Ergete, Ashenif Tadele, Samuel Woldekidan, Abiy Abebe, Girma Seyoum
      Pages: 95 - 104
      Abstract: Moringa stenopetala (Baker f.) Cufod. (Moringaceae) is a fast-growing tropical plant used as a native vegetable in southwestern Ethiopia. The plant is used for treating different diseases like malaria, hypertension, stomach pain, diabetes, and retained placenta. Yet, evidence of its teratogenicity is limited. The current study aimed to assess the toxic effects of M. stenopetala leaf on rat embryos. The leaves of M. stenopetala were extracted using 70% ethanol. Five groups of animals, each containing ten pregnant rats, were used for the current study. The first three groups were treated with 250, 500, and 1000 mg/kg M. stenopetala leaf extract, respectively. The last two groups were pair-fed and ad libitum control groups. The extract was administered from gestation days 6 to 12. Embryos were recovered at day 12 of gestation and assessed for growth retardations and development delays. When compared with the pair-fed control group, the maternal daily food intake and weight gain were slightly reduced in the high (1000 mg/kg) treated group, but it was not statistically significant. Increased numbers of resorption sites were observed in the 1000 mg/kg treated group when compared with the pair-fed control group. The number of embryos was also significantly reduced in the high dose treated group. The crown-rump length, number of somites, yolk sac diameter, and morphological scores of the embryos were also significantly reduced in 1000 mg/kg treated rats when compared with the pair-fed control group. When compared to pair-fed control group, the high dose treated rats had developmental delays in the yok sac circulation, otic system, and somite score. Therefore, administration of M. stenopetala leaves at a higher dose was found to have toxic effects on the development of rat embryos. It increased resorption sites and reduced the number of embryos at a higher dose. In addition, it delayed the development of yolk sac circulation, sensory otic system, and somite scores in the high dose treated rat embryos. Hence, it is recommended to limit excess consumption of M. stenopetala leaves during pregnancy.
      PubDate: 2023-08-18
      Issue No: Vol. 37, No. 2 (2023)
       
  • Anti-Inflammatory Activity of 80% Methanol Leaf Extract of Urtica simensis
           Steudel (Urticacaeae) in Rodents

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      Authors: Getu Dadi, Workineh Shibeshi
      Pages: 105 - 114
      Abstract: The leaves of Urtica simensis Steudel (Urticacaeae) have long been used traditionally to cure a variety of diseases, including eye injuries, gonorrhea, erectile dysfunction, malaria and peptic ulcer disease. They are also claimed to have anti-inflammatory and wound-healing properties. However, there is no scientific evidence to back-up the traditional assertions. The aim of this study was to evaluate in vivo anti-inflammatory activity and to quantitatively determine the major chemical constituents of the 80% methanol leaf extract of U. simensis. The anti-inflammatory activity was evaluated at doses of 100, 200 and 400 mg/kg of the leaf extract using acute model of inflammation (carrageenan induced hind paw oedema) and chronic model of inflammation (cotton pellet induced granuloma) in rats. U. simensis leaf extract had a statistically significant effect on the carrageenan-induced paw oedema and cotton pellet-induced granuloma models. The 400 mg/kg dose demonstrated maximum percent of inhibition of oedema i.e. 27.61% and 35.42%; p < 0.001 at 3rd and 4th h of post-induction, respectively, which is comparable to indomethacin. All the tested doses showed significant (p < 0.001) exudate and granuloma inhibition in cotton pellet induced granuloma model. Phytochemical analysis revealed total values of 26.70 ± 0.14 mg GAE/g of dry weight of extract for phenolic compounds, 13 ± 0.18 mg QE/g of dry weight of extract for flavonoids, and 17.06 ± 0.11 mg AE/g of dry weight of extract for alkaloids in the 80% methanolic leaf extract of U. simensis. Data obtained from the present study generally justified that the 80% methanol leaf extract of U. simensis had significant anti-inflammatory activities, supporting the folkloric use of the plant.
      PubDate: 2023-08-18
      Issue No: Vol. 37, No. 2 (2023)
       
  • Synthesis and Characterization of Cellulose Acetate from Khat (Catha
           edulis
    ) Waste

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      Authors: Kebede Wondu, Elias Jemal, Jemal Dilebo, Tesfaye Gabriel
      Pages: 115 - 128
      Abstract: Agro-industries produce a lot of lignocellulosic waste, and using this cellulose-rich waste can help with both ecological and economic issues. In this study, cellulose fibers were isolated from a locally abundant source of khat waste and homogeneously acetylated to produce cellulose acetate. In order to determine their yield, chemical functionality, crystallinity, shape, and thermal stability, the as-obtained cellulose fibers and cellulose acetate were analyzed. Cellulose content on a dry weight basis was found to be about 40% in untreated khat waste and about 90% in as-obtained cellulose fibers. The degree of substitution of cellulose acetate ranged from 1.4 to 2.1 with weight gains from 133 to 146% (w/w). SEM images indicated that the asobtained cellulose existed as a fibrous and elongated structure while the cellulose acetate was granular. The FTIR results showed the removal of non-cellulosic materials during chemical treatments of khat waste. Furthermore, an effective attachment of acetate groups was confirmed by the appearance of new peaks around 1743 cm-1, 1368 cm-1, and 1221 cm-1 in the FTIR spectra of cellulose acetate. The elimination of noncellulosic components, notably hemicellulose and lignin, was demonstrated by an increase in the crystallinity index (CrI) of extracted cellulose (73%) after chemical treatment of untreated khat waste (56%). This index then reduced in the cellulose acetate following esterification. This study is beneficial for developing cellulose and cellulose acetate from khat waste as an alternative source for various potential value-added applications.
      PubDate: 2023-08-18
      Issue No: Vol. 37, No. 2 (2023)
       
  • Chemical Composition and In Vitro Antimicrobial Activity of the Essential
           Oil of the Roots of Silene macrosolen

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      Authors: Gizachew Kassahun Bizuneh, Daniel Bisrat, Peter Lindemann, Kaleab Asres
      Pages: 129 - 136
      Abstract: Medicinal plants have always played a crucial role as sources for drug lead compounds. Thus, the objective of this study was to qualitatively identify and quantitatively determine the chemical compositions of the essential oil extracted from the roots of Silene macrosolen Steud. ex A. Rich (Caryophyllaceae) and also to quantitatively assay the antimicrobial efficacy of the essential oil against selected medicinally important pathogenic microorganisms. The essential oil was extracted from the root of S. macrosolen by hydrodistillation using Clevenger-type apparatus and analyzed for its chemical compositions by capillary gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the oil was evaluated on ten bacterial and three fungal species using the microdilution technique. GC-MS analysis of the essential oil resulted in the identification of 44 compounds that account for 64.63% of the total oil content. The major constituents of the oil were hydrocarbons that include 3,7-dimethyldecane (11.29%), tridecane (9.42%), 4-ethyltetradecane (6.92%), pentadecane (4.90%), and 7-methyl-1-undecene (4.62%). Overall, the oil showed higher antibacterial activities against Gram-positive than Gram-negative bacteria. In particular, the oil exhibited strong activity against Staphylococcus aureus and Staphylococcus epidermidis with an MIC value of 31.5 μg/ml. The results indicate that the essential oil of S. macrosolen roots contains mainly long-chain hydrocarbons which may be responsible for the antimicrobial activity of the plant.
      PubDate: 2023-08-18
      Issue No: Vol. 37, No. 2 (2023)
       
  • Distilled Lupinus albus Seeds Induce Vasorelaxation by Activation of
           eNOS-NO-cGMP Pathway and Direct Inhibition of Voltage Dependent Calcium
           Channels

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      Authors: Yoseph Likey, Abiy Abebe, Samuel Woldekidan, Workineh Shibeshi
      Pages: 137 - 148
      Abstract: Hypertension is a global health problem that needs exploration for new therapeutics. The community in North Western Ethiopia uses a local alcoholic beverage prepared from Lupinus albus L. seeds for the treatment of hypertension. Although this preparation has been traditionally used as an antihypertensive preparation, it lacks scientific evidence regarding efficacy and possible mechanisms of its antihypertensive action. The aim of this study was to investigate the ex vivo vasorelaxation activity and possible mechanisms of L. albus seed distillate (“gebto arekei”) in isolated guinea pig thoracic aorta. The vasorelaxation effect of different concentrations of the distillate (4 - 32 μg/ml) was investigated in isolated thoracic aorta strips pre-contracted by either epinephrine (1 μM) or potassium chloride (80 mM) using ex vivo isometric tension recording method. The extract induced vasorelaxation response in both endothelium intact and endothelium denuded strips as well as strips pre-incubated with NG-nitro-L-arginine methyl ester (L-NAME) and methylene blue (MB) in concentration-dependent manner. The distillate showed synergistic activity when combined with sodium nitroprusside. Determination of calcium concentration responses revealed significant inhibition of contraction. The concentration that caused maximal relaxation and 50% maximal relaxation was found to be 4.74 μg/ml and 3.80 μg/ml, respectively, in epinephrine pre-contracted endothelium intact strips, whereas it was 21 μg/ml and 7.01 μg/ml in strips pre-contracted with potassium chloride. Distilled L. albus seeds showed vasodilatory effect through endothelial nitric oxide synthase-nitric oxide-cyclic guanosine monophosphate pathway and direct inhibitory effect on voltage dependent calcium channels that supports its traditional use in the treatment of hypertension.
      PubDate: 2023-08-18
      Issue No: Vol. 37, No. 2 (2023)
       
  • In Vitro Antiprotozoal Activity of the Leaf Latex of Caralluma speciosa
           Against Two Leishmania Species

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      Authors: Alemu Tadesse Feroche, Kalkidan Derese, Kaleab Asres
      Pages: 149 - 156
      Abstract: The alarming growth of parasite resistance has increased the urgency of finding novel therapeutic compounds for the treatment of protozoal diseases such as leishmaniasis. Previous studies have demonstrated that several plants belonging to the genus Caralluma possess antiprotozoal activity against malaria, trypanosomiasis and leishmaniasis. In the present study, the antiprotozoal activity of the methanolic extract of the leaf latex obtained from the Ethiopian plant Caralluma speciosa N. E. Br. (family Asclepiadaceae) was evaluated by in vitro testing against Leishmania aethiopica and L. donovani. Antileishmanial activity test was carried out using the Alamar Blue assay on promastigotes and axenic cultured amastigotes of L. aethiopica and L. donovani clinical isolates, and cell viability was fluorometrically determined. Amphotericin B was used as a positive control, and 1% dimethyl sulfoxide (DMSO) and the media were employed as a negative control. Results of the study indicated that the latex possessed good activity against both parasites with IC50 values of 18.32 ± 0.85 and 26.21 ± 0.90 μg/ml against promastigotes, and 25.72 ± 0.76 and 25.33 ± 0.65 μg/ml against axenically cultured amastigotes of L. aethiopica and L. donovani, respectively. Furthermore, the latex showed selectivity indices (SIs) of 7.88 and 5.51 toward promastigotes and 5.61 and 5.70 toward amastigotes, while amphotericin B demonstrated SIs of 10.32 and 10.55 toward promastigotes and 9.76 and 10.10 toward amastigotes of L. aethiopica and L. donovani, respectively. The findings of this investigation attest that the latex of C. speciosa is endowed with promising antileishmanial activity against and L. aethiopica and L. donovani warranting further investigations into the active constituents.
      PubDate: 2023-08-18
      Issue No: Vol. 37, No. 2 (2023)
       
 
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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 27)
AAPS Open     Open Access   (Followers: 5)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 2)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 92)
Advanced Herbal Medicine     Open Access   (Followers: 10)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 13)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 8)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 5)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 4)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 11)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 6)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 6)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 20)
American Journal of Drug Discovery and Development     Open Access   (Followers: 2)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 51)
American Journal of Pharmacological Sciences     Open Access   (Followers: 2)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 21)
American Journal of Therapeutics     Hybrid Journal   (Followers: 11)
Analytical Methods     Hybrid Journal   (Followers: 7)
Annales Pharmaceutiques Francaises     Full-text available via subscription  
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 51)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 26)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 6)
Antibiotics     Open Access   (Followers: 12)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 7)
Applied Clinical Trials     Full-text available via subscription   (Followers: 5)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 1)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Archives of Razi Institute     Open Access   (Followers: 1)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Pharmaceutics     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Pharmaceutical Journal     Full-text available via subscription  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 11)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Bioanalysis     Full-text available via subscription   (Followers: 6)
Biochemical Pharmacology     Hybrid Journal   (Followers: 9)
BioDrugs     Full-text available via subscription   (Followers: 4)
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 1)
Biomarkers in Drug Development     Partially Free   (Followers: 1)
Biomaterials     Hybrid Journal   (Followers: 54)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 1)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 6)
Biopharm International     Full-text available via subscription   (Followers: 8)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 11)
BMC Pharmacology     Open Access   (Followers: 3)
BMC Pharmacology & Toxicology     Open Access   (Followers: 5)
Brazilian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 25)
British Journal of Pharmacology     Hybrid Journal   (Followers: 14)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 1)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 12)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical and Pharmaceutical Bulletin     Full-text available via subscription  
Chemical Research in Toxicology     Hybrid Journal   (Followers: 20)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Ciencia e Investigación     Open Access  
Ciência Equatorial     Open Access  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 3)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access   (Followers: 2)
Clinical Drug Investigation     Full-text available via subscription   (Followers: 6)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 11)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 16)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 31)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 2)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 5)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 5)
Clinical Therapeutics     Hybrid Journal   (Followers: 10)
Clinical Toxicology     Hybrid Journal   (Followers: 17)
Clinical Trials     Hybrid Journal   (Followers: 12)
CNS Drug Reviews     Open Access   (Followers: 3)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 6)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Therapeutic Drug Carrier Systems     Full-text available via subscription  
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 22)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 3)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 5)
Current Drug Metabolism     Hybrid Journal   (Followers: 3)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 2)
Current Drug Therapy     Hybrid Journal   (Followers: 2)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 7)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 4)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 1)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 5)
Current Therapeutic Research     Open Access   (Followers: 5)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 7)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 1)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 3)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 12)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 7)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 1)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 24)
Drug Development Research     Hybrid Journal   (Followers: 8)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 7)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 8)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 3)
Drug Metabolism Letters     Hybrid Journal   (Followers: 2)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 3)
Drug Research     Hybrid Journal   (Followers: 1)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 78)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 8)
Drugs     Full-text available via subscription   (Followers: 139)
Drugs & Aging     Full-text available via subscription   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs and Therapy Studies     Open Access  
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 4)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Egyptian Pharmaceutical Journal     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 2)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 7)
Epilepsy Research     Hybrid Journal   (Followers: 8)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 11)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 5)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 82)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 23)
European Journal of Pharmacology     Hybrid Journal   (Followers: 3)
European Medical, Health and Pharmaceutical Journal     Open Access   (Followers: 2)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 8)
European Pharmaceutical Journal     Open Access  

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