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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
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East and Central African Journal of Pharmaceutical Sciences
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1026-552X
Published by African Journals Online Homepage  [261 journals]
  • Use of traditional medicines in pregnancy

    • Authors: Kennedy O. Abuga
      Pages: 48 - 49
      Abstract: No Abstract.
      PubDate: 2022-08-19
      Issue No: Vol. 24, No. 2 (2022)
  • Methanol Root Extract of Rhaphiostylis beninensis Planch Ex Benth
           (Icacinaceae) Reverses Alcohol-induced Changes in Sex Hormones and Semen
           Quality in Male Rats

    • Authors: Joshephine O. Ofeimun, Adeshid B. Ayinde, Gerald I. Eze
      Pages: 50 - 56
      Abstract: The methanol root extract of Rhaphiostylis beninensis was investigated for its ability to reverse alcohol-induced changes in sex hormones, semen  quality and histoarchitecture of testes in male rats. Rats were divided into 5 groups, namely, normal control (1), negative control (2), extract treated (3 and 4) and vitamin E treated (5). The rats were fed 20% v/v alcohol except for those in group 1. In addition, groups 3 and 4 rats received the extract at concentrations of 200 and 400 mg/kg, respectively while group 5 received 300 mg/kg of vitamin E. After 30 days, serum concentrations of testosterone, estrogen, progesterone, prolactin, follicle stimulating  hormone, and luteinizing hormone were determined. Sperm count, motility, morphology and histoarchitecture of testes were also evaluated. Significant increase (p < 0.01) in serum concentration of testosterone, sperm count, and progressive motility was observed in extract-treated groups. Increase in spermatogenic activity of testes of extracttreated rats was also observed, suggesting that the plant extract may be useful in ameliorating alcohol-induced male reproductive toxicity. 
      PubDate: 2022-08-19
      Issue No: Vol. 24, No. 2 (2022)
  • Quality Control Results of Pharmaceuticals Analyzed in the Mission for
           Essential Drugs and Supplies (MEDS) Laboratory During the Period 2013-2017

    • Authors: Kennedy O. Abuga, Stephen T. Kigera, Mildred Wanyama, Wycliffe M. Nandama, Isaac O. Kibwage
      Pages: 57 - 66
      Abstract: During the 2013-2017 period, the MEDS laboratory received and processed 6853 samples. Samples were sourced from Kenya and other sub-Saharan Africa countries. The samples submitted comprised Kenyan manufactured (31.9%) and internationally manufactured products (67.9%) while nine samples were of unknown origin. Analysis was carried out according to compendial and/or in-house specifications. The non-compliance rate was 5.1% consisting of 1.2 % local and 3.8% imports. The top ten drug classes with high failure rates were antimyasthenics (50.0%), ntiseptics/disinfectants (24.7%), anthelminthics (22.0%), thyroid/antithyroid drugs (20.0%), nutrient mixtures (18.5%), uricosurics (12.5%), waters (11.6%), mixed anti-infectives (11.1%), hemostatics (10.0%) and nootropics (10.0%). Full compliance was however, recorded with laxatives, antidiarrheals, antihemorrhoidals, prokinetics, antithrombotics, antithrombocytopenia agents, vasopressors, anti-arrhythmic drugs, anti-anginal drugs, disease modifying antirheumatic drugs, antimigraine drugs, vertigolytics, muscle relaxants, bisphosphonates, joint lubricants, hormones, anticholinergics, osmotic diuretics, hypophosphatemics, lubricants, minerals, amino acids/peptides, immunomodulatory agents, choleretics, antidotes, lozenges, ear drops, proteins/glycoproteins, herbal products, X-ray contrast media, vaccines, environmental monitoring, medical devices/equipment and cleaning validation swabs. A total of 23 substandard and falsified medicines devoid of active ingredients were encountered over the five-year period. The results obtained demonstrate the need to strengthen regulatory stringency in order to curb incidences of substandard and falsified medicines.
      PubDate: 2022-08-19
      Issue No: Vol. 24, No. 2 (2022)
  • Knowledge, attitude and practice towards control of Ebola infection among
           community pharmacy workers in Dar es Salaam Tanzania

    • Authors: Vicky Peter Manyanga, Revina Haule, Raphael Zozimus Sangeda
      Pages: 67 - 76
      Abstract: Ebola virus disease (EVD) is an acute and severe illness without specific treatments that has a very high case fatality rate of up to 90%. The disease is a major global health problem, yet the knowledge of the disease to the community, including health care workers, is low. Community pharmacy workers (CPW), being the first line to contact patients, play a crucial role in providing over-the-counter medications, awareness, and knowledge on various diseases and disease prevention strategies in the community. Thus, CPWs should be aware of the signs and symptoms for prompt and appropriate referral of persons suspected of EVD. This study's main objective was to assess the awareness, attitude and perceptions towards the control of Ebola infection by CPWs in Dar es Salaam, Tanzania. A cross-sectional study was conducted using convenience sampling to recruit consenting CPWs surveyed using a self-administered questionnaire. A total of 252 community pharmacy workers were recruited. A female preponderance of 160 (63.5%) was observed with an average age of 30.7±8.5years (mean ± SD), with the majority (55.6%) in the 20-29 years age
      group. The main source of information about EVD by the CPWs was television (71.8%), newspapers and radio 67.9% and 67.5%, respectively. Direct contact with blood was identified as the main route of transmission of Ebola by 81.3% of CPWs, followed by air (38.5%). When all the individual positive scores for questions on general knowledge of EVD transmission were computed and categorized into low (1-5), average (6-10) and excellent (11-20) knowledge, the majority of respondents (52.8%), had an average knowledge score. However, a positive attitude and practices were revealed by the CPWs towards ways of preventing Ebola. Several misconceptions about Ebola were, however, noted among the participants. Ebola transmission can be prevented by appropriately educating CPWs as a strategy to increase preparedness for an EVD outbreak.
      PubDate: 2022-08-19
      Issue No: Vol. 24, No. 2 (2022)
  • Prevalence and factors associated with use of herbal medicine among
           pregnant women in an urban tertiary hospital in Uganda – a
           cross-sectional survey

    • Authors: Hood Ahmed Ibanda, Peter Ntuyo, Frank Mubiru, Fatuma Namusoke
      Pages: 78 - 84
      Abstract: Herbal medicine is used by pregnant women in Uganda to achieve therapeutic goals like induction of labour and control of postpartum haemorrhage. This study aimed at finding out the prevalence and determinants of herbal medicine use during pregnancy by women in an urban tertiary hospital in Uganda. In this cross-sectional survey, 520 postpartum women participated after informed consent. Data on demographic characteristics and selfreported use/non-use of herbal medicine in the just ended pregnancy were collected. Using modified Poisson regression model, factors associated with use of herbal medicine in pregnancy were determined. Prevalence of herbal medicine use in pregnancy was 69.8 %( 363/520). Use of herbal medicine in past pregnancy (PR=3.23, 95% CI=2.23-4.67), believing that herbal medicine is safe (PR=1.1 95% CI=1.01-1.21), and advise by family members to use herbal medicine (PR=1.64, 95% CI=1.04-2.59) were determinants of use herbal medicine during pregnancy. Majority of pregnant women in urban Mulago hospital use herbal medicine to treat common complaints. Further research is needed to document the herbs, their efficacy, and possible effects on birth outcomes.
      PubDate: 2022-08-19
      Issue No: Vol. 24, No. 2 (2022)
  • Quality of Metformin Tablet Products in the Kenyan Market

    • Authors: Eunice M. Kariuki, Grace N. Thoith
      Pages: 85 - 89
      Abstract: The quality of 14 metformin hydrochloride tablet products locally available in the Kenyan market is reported. The samples composed both 500 mg and 850 mg strengths. The compendial tests performed included uniformity of weight, disintegration, friability, hardness, assay and dissolution. Assay and dissolution were determined by ultra-violet spectrophotometry. All the samples had a deviation of less than ± 5% from the mean average weight in the uniformity of weight test, disintegrated within 5-17 minutes and had a friability of less than 1%. They yielded satisfactory hardness and acceptable dissolution within 45 minutes. However, two samples failed to meet the British Pharmacopoeia specifications for assay.
      PubDate: 2022-08-19
      Issue No: Vol. 24, No. 2 (2022)
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