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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted alphabetically
Microbial Drug Resistance     Hybrid Journal   (Followers: 3)
Molecular Informatics     Hybrid Journal   (Followers: 5)
Molecular Pharmacology     Hybrid Journal   (Followers: 2)
Molekul     Open Access   (Followers: 1)
Natural Product Communications     Open Access  
Nature Reviews Drug Discovery     Full-text available via subscription   (Followers: 310)
Naunyn-Schmiedeberg's Archives of Pharmacology     Hybrid Journal  
NeuroMolecular Medicine     Hybrid Journal  
Neuropharmacology     Hybrid Journal   (Followers: 5)
Neuropsychopharmacology     Hybrid Journal   (Followers: 17)
Neuropsychopharmacology Reports     Open Access  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Drug Design & Delivery     Open Access  
OA Medical Hypothesis     Open Access  
Obesity Facts     Open Access   (Followers: 8)
Open Pharmacoeconomics & Health Economics Journal     Open Access   (Followers: 1)
Open Pharmacology Journal     Open Access  
OpenNano     Open Access   (Followers: 1)
Orbital - The Electronic Journal of Chemistry     Open Access   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Pain and Therapy     Open Access   (Followers: 3)
Particulate Science and Technology: An International Journal     Hybrid Journal   (Followers: 1)
PDA Journal of Pharmaceutical Science and Technology     Full-text available via subscription   (Followers: 33)
Pediatric Drugs     Full-text available via subscription   (Followers: 3)
Pediatric Pharmacology     Open Access   (Followers: 1)
Pharmaceutica Analytica Acta     Open Access  
Pharmaceutical Biology     Open Access  
Pharmaceutical Care-La Farmacoterapia     Open Access  
Pharmaceutical Chemistry Journal     Hybrid Journal  
Pharmaceutical Development and Technology     Hybrid Journal   (Followers: 19)
Pharmaceutical Executive     Full-text available via subscription   (Followers: 2)
Pharmaceutical Fronts     Open Access   (Followers: 8)
Pharmaceutical Historian     Open Access  
Pharmaceutical Journal     Free   (Followers: 8)
Pharmaceutical Journal of Sri Lanka     Open Access  
Pharmaceutical Medicine     Full-text available via subscription   (Followers: 4)
Pharmaceutical Nanotechnology     Hybrid Journal  
Pharmaceutical Patent Analyst     Full-text available via subscription   (Followers: 3)
Pharmaceutical Research     Hybrid Journal   (Followers: 93)
Pharmaceutical Statistics     Hybrid Journal   (Followers: 15)
Pharmaceutical Technology     Full-text available via subscription   (Followers: 6)
Pharmaceuticals     Open Access   (Followers: 4)
Pharmacia     Open Access  
Pharmaciana     Open Access  
PharmacoEconomics     Full-text available via subscription   (Followers: 25)
PharmacoEconomics & Outcomes News     Full-text available via subscription   (Followers: 2)
PharmacoEconomics German Research Articles     Full-text available via subscription  
PharmacoEconomics Spanish Research Articles     Hybrid Journal   (Followers: 1)
Pharmacoepidemiology and Drug Safety     Hybrid Journal   (Followers: 33)
Pharmacogenetics and Genomics     Hybrid Journal   (Followers: 1)
Pharmacogenomics     Hybrid Journal   (Followers: 7)
Pharmacogenomics and Personalized Medicine     Open Access   (Followers: 2)
Pharmacogenomics Journal     Hybrid Journal   (Followers: 5)
Pharmacognosy Communications     Partially Free  
Pharmacognosy Magazine     Open Access   (Followers: 2)
Pharmacognosy Research     Open Access   (Followers: 2)
Pharmacological Reports     Hybrid Journal  
Pharmacological Research     Hybrid Journal   (Followers: 1)
Pharmacological Research - Modern Chinese Medicine     Open Access  
Pharmacological Reviews     Hybrid Journal   (Followers: 2)
Pharmacology     Full-text available via subscription  
Pharmacology & Therapeutics     Hybrid Journal   (Followers: 3)
Pharmacology & Pharmacy     Open Access   (Followers: 1)
Pharmacology Biochemistry and Behavior     Hybrid Journal   (Followers: 2)
Pharmacology Research & Perspectives     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacopsychiatry     Hybrid Journal   (Followers: 3)
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy     Hybrid Journal   (Followers: 37)
Pharmactuel     Open Access   (Followers: 1)
Pharmacy     Open Access   (Followers: 4)
Pharmacy & Pharmacology     Open Access   (Followers: 1)
Pharmacy Education     Full-text available via subscription   (Followers: 11)
Pharmacy Practice (Internet)     Open Access   (Followers: 8)
Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
PharmaNutrition     Hybrid Journal   (Followers: 3)
PharmaTutor     Open Access  
Pharmazeutische Industrie     Full-text available via subscription   (Followers: 9)
Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 11)
Pharmazie in Unserer Zeit (Pharmuz)     Hybrid Journal   (Followers: 11)
Physiology International     Full-text available via subscription   (Followers: 3)
Plant Products Research Journal     Full-text available via subscription  
Planta Medica     Hybrid Journal   (Followers: 4)
Planta Medica International Open     Open Access  
Prescriber     Hybrid Journal   (Followers: 9)
Progress in Neuro-Psychopharmacology and Biological Psychiatry     Hybrid Journal   (Followers: 8)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Psychopharmacology     Hybrid Journal   (Followers: 15)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Redox Report     Open Access  
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 41)
Research & Reviews : A Journal of Drug Design & Discovery     Full-text available via subscription  
Research & Reviews : A Journal of Pharmaceutical Science     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacognosy     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacology     Full-text available via subscription   (Followers: 1)
Research in Pharmaceutical Sciences     Open Access   (Followers: 3)
Research in Social and Administrative Pharmacy     Hybrid Journal   (Followers: 3)
Research Journal of Pharmacognosy     Open Access  
Research Results in Pharmacology     Open Access  
Reviews of Physiology, Biochemistry and Pharmacology     Hybrid Journal   (Followers: 4)
Reviews on Clinical Pharmacology and Drug Therapy     Full-text available via subscription  
Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Revista Cubana de Plantas Medicinales     Open Access   (Followers: 1)
Revista de Ciências Farmacêuticas Básica e Aplicada     Open Access  
Revista Mexicana de Ciencias Farmaceuticas     Open Access  
Revue de Médecine et de Pharmacie     Full-text available via subscription  
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Saudi Pharmaceutical Journal     Open Access  
Scandinavian Journal of Clinical and Laboratory Investigation     Hybrid Journal   (Followers: 7)
Scientia Pharmaceutica     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Seminars in Oncology Nursing     Full-text available via subscription   (Followers: 10)
Separation Science plus (SSC plus)     Hybrid Journal  
Side Effects of Drugs Annual     Full-text available via subscription   (Followers: 2)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 6)
Substance Abuse : Research and Treatment     Open Access   (Followers: 5)
Suchttherapie     Hybrid Journal   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 5)
SynOpen     Open Access  
The Botulinum J.     Hybrid Journal  
The Brown University Psychopharmacology Update     Hybrid Journal   (Followers: 2)
The Medical Letter     Full-text available via subscription   (Followers: 18)
The Pink Sheet     Full-text available via subscription   (Followers: 12)
The Pink Sheet Daily     Full-text available via subscription   (Followers: 4)
Therapeutic Advances in Drug Safety     Open Access   (Followers: 3)
Therapeutic Advances in Psychopharmacology     Open Access   (Followers: 4)
Therapeutic Advances in Vaccines     Hybrid Journal   (Followers: 1)
Therapeutic Drug Monitoring     Hybrid Journal   (Followers: 3)
Therapeutic Innovation & Regulatory Science     Hybrid Journal   (Followers: 7)
Thérapie     Full-text available via subscription   (Followers: 1)
TheScientist     Free   (Followers: 5)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Toxicological Research     Hybrid Journal  
Toxicological Sciences     Hybrid Journal   (Followers: 11)
Toxicology     Hybrid Journal   (Followers: 18)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 24)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Toxicology in Vitro     Hybrid Journal   (Followers: 11)
Toxicology International     Full-text available via subscription   (Followers: 5)
Toxicology Letters     Hybrid Journal   (Followers: 15)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 7)
Toxicology Research     Partially Free   (Followers: 8)
Toxicon     Hybrid Journal   (Followers: 5)
Toxicon : X     Open Access  
Toxin Reviews     Hybrid Journal  
Translational Psychiatry     Open Access   (Followers: 14)
Trends in Peptide and Protein Sciences     Open Access  
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 19)
Tropical Journal of Pharmaceutical Research     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Vascular Pharmacology     Hybrid Journal   (Followers: 2)
World Mycotoxin Journal     Hybrid Journal   (Followers: 3)
Yakugaku Zasshi     Open Access   (Followers: 1)
Zeitschrift für Phytotherapie     Hybrid Journal   (Followers: 1)
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
Фармацевтичний часопис     Open Access  

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Advances in Pharmacology and Pharmacy
Number of Followers: 5  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2332-0036 - ISSN (Online) 2332-0044
Published by Horizon Research Publishing Homepage  [50 journals]
  • Investigating the Efficacy of Black Cumin Seeds Hydroethanolic Extract in
           Reducing Cyclophosphamide-Induced Genotoxicity

    • Abstract: Publication date:  July 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  3  Mohammad Y. Abajy   Ream Nayal   Mahassen Alqubaji   and Yara Abdrabbo   Cyclophosphamide is a very important chemotherapy drug for patients with cancers and autoimmune diseases, but unfortunately it is a mutagenic and cytotoxic agent. In this research, the effectiveness of black cumin (Nigella sattiva) seeds hydroethanolic extract in reducing cyclophosphamide-induced genotoxicity was studied after determining the safety of this extract. The acute and subacute toxicity of the extract was evaluated at a dose of 1500mg/kg/day in albino rats. The extract did not lead to any deaths or behavioral pattern changes in rats, in addition, the biochemical analysis and the results of the relative organ weights showed the absence of any toxicity for the extract. The anti-mutagenic ability of the extract was evaluated using in vivo chromosomal aberration test and in vitro comet assay. Results showed that oral administration of the extract to rats before treatment with cyclophosphamide caused a significant decrease in chromosomal aberrations. In comet assay, the extract showed also significant reduction in cyclophosphamide-induced DNA migration. It could be concluded that black cumin seeds extract had a protective effect against Cyclophosphamide - induced genotoxicity and may be considered as an anti-mutagenic agent after conducting more studies.
      PubDate: July 2022
  • Chronomodulated Mucoadhesive Gastroretentive Drug Delivery System of

    • Abstract: Publication date:  July 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  3  Haranath Chinthaginjala   Hindustan Abdul Ahad   and Bhupalam Pradeepkumar   In the present study, the main objective was to develop and evaluate a novel floating mucoadhesive drug delivery system for famotidine. In order to deliver drugs in accordance with circadian behavior, continuous drug delivery systems were developed. It represents that these systems will deliver the drug when the patient's condition is at most risk. The combination of floating behaviour with the formulation improves the gastric dosage residence. The method adopted for the preparation of tablets was press coating technology. Here it has two layers: a core layer and a coat layer. The core layer consists of active ingredients, and the coat possesses gas-generating agents and polymers like HPMC, Carbopol, and Pectin. The formulations were characterised for weight variation, friability, hardness, disintegration of core tablets, in vitro drug release studies and Ex vivo mucoadhesive studies. All the formulations manifested better results in terms of floating lag time, floating time of more than 8 hours and good adhesion property. The formulation F6 manifested drug release of 99.42% at the end of 7 hours. It was concluded that the formulation F6 is the best formulation which accomplishes the anticipated release with specific lag time and has the ability for off release followed by burst release which can effectively suppress nocturnal histamine level and hence suppress high nocturnal acid release.
      PubDate: July 2022
  • Central Composite Design Screened Mastic Gum Abetted Mucoadhesive
           Microspheres of Amoxicillin Trihydrate for Exterminating H. pylori

    • Abstract: Publication date:  July 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  3  Sowjanya Hatthi Belgal Mundarinti   and Hindustan Abdul Ahad   Aim: Searching for a new polymer that can be used in pharmaceutical formulation is a laborious and cost oriented practice. To resolve this, researchers are in search of a cost-effective and reliable excipient. Synthetic polymers are costly, whereas natural ones are abundant and economical. In the same way, discovering a new drug is a horrendous process with time, cost, and approval. The study's goal is to investigate Mastic gum's mucoadhesive properties by incorporating it into mucoadhesive microspheres with Amoxicillin trihydrate as a model drug. Methods: Nine interpretations of mucoadhesive microspheres were made with carbomer 934P and varying proportions of mastic gum (MG). A central composite design with design expert software is used to check the impact of independent variables (mastic gum and carbomer 934 P levels) on entrapment efficacy and mucoadhesion time as the responses. As part of congeniality studies, the microspheres were examined for amoxicillin trihydrate (ATH) content and liberation. Results: Good quality microspheres were formed that showed suitability with the excipients and possessed appreciable outcomes for the tests conducted. The study expressed the equation for ATH entrapment as +82.70+0.1333A+6.40B+0.0500AB+ 0.0000A2-2.80B2 and the mucoadhesion time as +13.10+0.2500A+1.42B-0.0500AB+0.1500A2+0.1500B2. These equations indicate the impact of independent variables on the response studies. These equations discovered that ATH entrapment increased with an increase in MG levels in the formulations and that the mucoadhesion time was greater in formulations with higher MG levels. In formulations containing higher levels of MG, the drug release is slightly reduced. Conclusion: The study summarized that amoxicillin trihydrate is capable of good stomach-specific drug delivery by carbomer 934P and enhanced by mastic gum when prepared as mucoadhesive microspheres that are cost-effective, operational, and stable. This approach also resolves the gastric retention of ATH to eradicate H. pylori and the mastic gum has proved an anti-ulcer possession.
      PubDate: July 2022
  • Anti-Alzheimer's and Antioxidant Activity of Ethanolic Seed Extract of
           Sapindus emarginatus Vahl on Scopolamine-Induced Cognitive Impairment in

    • Abstract: Publication date:  July 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  3  Lalitha Vivekanandan   G. S. Sri Bharathi   Jagadeeswaran Murugesan   Kiruthiga Natarajan   and Sivakumar Thangavel   Background: Alzheimer's disease (AD) is a common nerve problem that leads to memory loss, particularly in the elderly. A shortage of acetylcholine in the brain, as well as oxidative stress, induces Alzheimer's disease. Currently, limited drugs are available to treat Alzheimer's disease because continuous use of these medications causes several side effects. Hence, we need high efficacious drugs to treat Alzheimer's disease with fewer side effects. Sapindus emarginatus Vahl or soap nut is a member of the Sapindaceae family. It's been used traditionally as an antiepileptic, antipruritic, antifertility, antiemetic, and anti-inflammatory agent. It is cheap, widely available, and reported to counteract chronic diseases linked to oxidative stress, such as ulcers and dyslipidemia. Objective: The purpose of this study was to determine the anti-Alzheimer and antioxidant properties of ethanolic seed extract of Sapindus emarginatus (ESSE) against scopolamine-induced amnesia. Methods: The total flavonoid level of the ESSE was estimated by a UV-visible spectrophotometer. The scopolamine (1 mg/kg/PO) was administered as a single intraperitoneal injection on the seventh day for induction of dementia in mice. The ESSE (250 and 500 mg/kg/PO) and donepezil (2.5 mg/kg/PO) was administered orally for 7 days. The neurobehavioral tests such as an elevated plus maze, radial arm maze, and Y-maze tests were undertaken for estimation of behavioral trials. The brain homogenate was used for the estimation of acetylcholine, acetylcholinesterase, and oxidative cell injury markers such as MDA, LH, SOD, CAT, and GSH. Results: The total flavonoid content of the extract was 0.47 mg of QE/g. Scopolamine degraded memory, as well as caused alterations in acetylcholine, acetylcholinesterase, and elevated oxidative stress in the brain. Pretreatment with ESSE reduced scopolamine-induced behavioral, neurochemical, and oxidative stress markers. Conclusion: The ESSE has an anti-amnesic impact, making it an attractive option for targeting multiple events as a possible technique to slow cognitive impairment.
      PubDate: July 2022
  • Preparation, Characterization of Bio-Based Zinc Oxide Nanoparticles and
           Its Microbicidal Potential over Chemical Based and Commerically Available

    • Abstract: Publication date:  July 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  3  Utkarsh Kaushik   and S. C. Joshi   Background and Objective: Nanotechnology has spread its roots and branches covering every field. Fascinating physcio-chemical properties and functional applications have made zinc oxide nanoparticles (ZnO NPs) one of the most multifaceted materials. Zinc oxide nanoparticles synthesis using concoction of plant is safer and nature cordial due to its non-toxic and clean compared to its chemical counterpart. Present quest involves zinc oxide nanoparticles production by chemical and biological methods (Citrus sinensis peel extract). Materials and Methods: Synthesized zinc oxide nanoparticles were characterized using ultraviolet-visible UV-Visible spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, and scanning electron microscopy (SEM). Synthesized zinc oxide nanoparticles at concentration (0.1g, 0.25g and 0.5g/10ml) were compared against microbial strains Staphylococcus epidermidis and Aspergillus flavus. Results: Synthesized ZnO NP's shows absorption peak at 356 nm in case of biological synthesis and 386 nm in case of chemical synthesized. FTIR proves the presence of alcohol, phenol, nitro compound; alkyne in case of biologically synthesized ZnO NPs and alkene, alkane, alkyl halides in case of chemically synthesized ZnO NPs. SEM confirmed the average size of 25-40 nm. Further, promising results were obtained at 0.5g/10ml of biologically synthesized ZnO NP's in case of Aspergillus flavus and Staphylococcus epidermidis. Conclusion: the biomimetic synthesis of ZnO nanoparticles could be an alternative to chemical synthesis and commercially available drugs.
      PubDate: July 2022
  • Characterization of Oxidative Degradation Product of Canagliflozin by

    • Abstract: Publication date:  July 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  3  Vijaya Vichare   Vishnu Choudhari   Vrushali Tambe   and Shashikant Dhole   Prior knowledge of chemical stability of drugs directs path for right selection of dosage form, excipients, storage conditions and packaging material. Literature survey revealed that, there are analytical methods reported for quantification and stability indication of Canagliflozin in bulk and formulation. But there is not much information available about the degradation products generated under different stability conditions. With this background, characterization of oxidative degradation product of Canagliflozin was successfully carried out by Liquid Chromatography-Mass Spectrometry (LC-MS/MS) studies. Degradation product was generated by forced degradation, according to International Conference on Harmonization (ICH) guidelines. Degradation product was separated from Canagliflozin by validated reverse phase (RP)-HPLC method using C18 column and Acetonitrile: Water pH 3.0 adjusted with 0.1% formic acid (70: 30, v/v) as mobile phase at a flow rate of 1mL/min. The developed RP-HPLC method was validated for different parameters as per ICH guidelines. The method was found to be linear in a range of 25-225 μg/mL. The developed method was found to be specific, accurate, precise, sensitive and robust. The marketed tablet formulation was analyzed by the developed method and the percent drug content was found to be 100.09 ± 1.96 % w/w. Separated degradation product was characterized by LC-MS/MS studies. From LC-MS/MS data probable structure of the degradation product was interpreted and the mechanism of degradation was proposed. The probable structure of degradation product was proposed as2-(4-Fluorophenyl)-5-({2-methyl-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl}methyl) thiophene-1-one. The mechanism of degradation was proposed by S-oxidation of thiophene ring to form thiophene oxide. This information will help synthetic chemists to design a synthesis scheme for the oxidative degradation product, which can be used as a reference standard for impurity profiling. It is also suggested to protect CN from oxidative conditions for improved stability.
      PubDate: July 2022
  • A Review on Traditional and Modern Therapy in Management of Poly Cystic
           Ovarian Syndrome

    • Abstract: Publication date:  July 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  3  Seema S Rathore   Navyashree G A   Komala M   Chinju Susan Chacko   and Shravya Lakshmi S   Diet and lifestyle of an individual play a major role in maintaining the health of an individual, and any variation associated with these two factors would lead to serious consequences. Polycystic ovarian syndrome is one such condition which is an endocrine disorder observed in teen aged and premenopausal women in modern world, where there is formation of cysts on the ovary/ ovaries. It may be due to increased secretion of androgen, imbalance in doshas (vata, pitta and kapha), improper diet and lifestyle. There are various medicated and non-medicated therapies available for reducing the symptoms and conditions associated with poly cystic ovarian syndrome. Medicated treatment involves maintenance of hormonal balance, Type II diabetes mellitus, infertility, synchronisation of the vata, pitta and kapha, insulin resistance, regularization of menstrual cycle, reduction of acne and hirsutism and these are done by administration of allopathic and herbal formulations. Non-medicated treatment includes surgery by which cysts are removed and also by acceptance of healthy lifestyle. This review centres on providing information regarding the medicated and non-medicated treatment available for treating the type of conditions and symptoms consorted with poly cystic ovarian syndrome along with their pros and cons.
      PubDate: July 2022
  • Evaluation of Anti Diabetic Activity of Ethanolic Seed Extract of Datura
           Innoxia Mill.

    • Abstract: Publication date:  Jan 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  1  Jincy Thomas   A. Srinivas   and Folitartha Roy   The current research has been performed to substantiate the traditional claim of the anti-diabetic activity of seeds of Datura Innoxia Mill. in rats. This plant contains scopolamine alkaloid, which has been reported to be used in operations as pre-anaesthesia, used in delivery, as well as in ocular surgeries and for travel sickness prophylaxis. Datura is a medicinal and hallucinogenic plant that is used everywhere in the globe. Datura is revered in Ayurveda because all parts of the plant have medicinal properties, including the roots, leaves, seeds, and flowers, and have been employed to treat a variety of ailments, including leprosy, rabies, and insanity. Withanolide has recently been found to have potent anti-tumor, anti-inflammatory, anti-bacterial, hepatoprotective, soporfic, cytotoxic, and immune suppressant properties. An alloxan-induced diabetes model in rats was used to test the anti-diabetic activity of an ethanolic extract of the seeds of Datura Innoxia Mill. (Family-Solanaceae). A comparison was made between both the animals treated with extract from seeds and animals treated with known drug for diabetes i.e.., glibenclamide. The extract dose was chosen based on acute oral toxicity tests conducted in accordance with OECD norms. The outcomes revealed the fact that ethanolic extract significantly reduced the glucose levels in blood. The findings supported the use of seeds extract in the treatment of diabetes.
      PubDate: Jan 2022
  • Phytochemical Analysis and Antimicrobial Studies of Lantana camara L.

    • Abstract: Publication date:  Jan 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  1  Naveen Kumar Kudure Jayanna   Venkatesh   Pradeepa Krishnappa   and Santosh Kumar Shimoga Rajanna   Lantana camara is considered as a notorious weed and a popular ornamental plant. It has been observed since ancient times because the plants are an excellent source of medicine. Lantana camara has long been considered one of the most important medicinal plants in the world. Lantana camara is used in traditional medicine to treat cuts, swelling, ulcers, cataracts, biliary fever, itching, eczema and rheumatism. Different parts of the Lantana camara plant are used to treat colds, headaches, whooping cough, asthma, chicken pox, bronchitis, eye lesions, and high blood pressure. Lantana camara has been scientifically studied for various therapeutic activities like antibacterial, antioxidant, antipyretic, insecticidal, antimicrobial, wound healing etc. Various literatures have reported the phytoconstituents present in all parts of Lantana camara. In the current study, phytochemical analysis and antimicrobial activity of leaves and stem of Lantana camara were studied. The phytochemical analysis using chloroform and ethanol extracts for phenolic acids (Gallic acid) and flavonoids (Quercetin, Myricetin) by HPLC method in stem and leaves of Lantana camara. The present study evaluated the antimicrobial activity of ethanol and chloroform leaves extract against some pathogenic bacteria and fungi by using agar well diffusion method. This study can be concluded that Lantana camara of steam and leaves are comprised of bioactive compounds which possess antimicrobial activity against pathogenic bacteria and fungi.
      PubDate: Jan 2022
  • Bacopa monnieri (Linn.) Pennell - A Possible Plant for Impossible Diseases
           (A Review)

    • Abstract: Publication date:  Jan 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  1  Abhishek Kumar Pandey   Since the beginning of humankind, people are using numerous plants to cure diseases and abnormalities. Bacopa monnieri has been used by people for a long time. This plant has several medicinal and biochemical properties which would be beneficial to treat diseases. The current review article summarizes the medicinal, presence of the bioactive compound, mechanism of action, therapeutic importance, clinical trials, ethnobotanical usage, and distribution of the plant with respect to India and worldwide. Relevant information and literature on Bacopa monnieri were extracted from different sources and their finding were discussed in the manuscript. The number of therapeutic properties of the plant has been seen in the animal model experiment including anti-diarrheal, antioxidant, anti-inflammatory, anti-cancer, anti-fungal, anti-bacterial, anti-convulsant, hepatoprotective, antiulcer, anti-depressant, anti-hyperglycemic and anti-nociceptive activity, immunostimulatory activity, and wound healing activity. This article recapitulates ethnopharmacological uses of Bacopa monnieri to explore its therapeutic potentials thereby providing a basis for future research. Bacopa monnieri exhibits a comprehensive of pharmacological activities that could be observed by the presence of a vast range of chemical constituents. Manuscript also comprises tissue culture techniques and propagation of Bacopa monnieri. The study also provides a descriptive outlook on the uses of Bacopa monnieri in wastewater treatment. This review article highlights the endless possibilities present in the plant and also sheds light on research that has not yet been done on this plant and may prove useful if done in the future.
      PubDate: Jan 2022
  • Cichotyboside, A Sesquiterpene Glycoside from Cichorium intybus Attenuates
           Carbon Tetrachloride-Induced Liver Injury in Rat

    • Abstract: Publication date:  Jan 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  1  Chandra Shekar Singh   and Papiya Bigoniya   Aims: Cichorium intybus L. is traditionally used for the management of the various liver disorders and also widely scientifically reported for hepatoprotection. The present study aims at investigating cichotyboside, bioactive sesquiterpene glycoside, from seeds for hepatoprotective effect against carbon tetrachloride (CCl4) following isolation and characterization. Methods: Cichotyboside was isolated from C. intybus seeds and characterized by infrared spectroscopy (IR), liquid chromatography-mass spectrometry (LC/MS), and carbon 13 nuclear magnetic resonance (13C NMR). High-performance liquid chromatography (HPLC) and high-performance thin-layer chromatography (HPTLC) have been developed for the standardization of Cichotyboside. In this study, biochemical assays, liver functional capacity restoration regarding drug metabolism, antioxidant potential, and histological staining were applied to evaluate the anti-hepatotoxic efficacy of cichotyboside on a carbon tetrachloride induced liver injury in rats. Results: The results showed that cichotyboside could significantly attenuate the pathological changes, increase the levels of hepatocyte repair, and regulate oxidative damage. Hepatoprotective activity of cichotyboside is indicated by its ability to decrease thiopental induced sleeping time, increased BSP clearance, reverse effect of CCl4 on the body weight, relative liver weight, serum liver function parameters, histopathology and activity of liver antioxidant enzymes. Conclusion: Cichotyboside exerts hepatoprotective activity against the CCl4 induced toxicity, possibly by its remarkable antioxidant potential, reversing the impaired metabolisms and repairing the fatty changes in hepatocytes.
      PubDate: Jan 2022
  • Evaluation of Nootropic Potential of Leucaena leucocephala on Wister Rats

    • Abstract: Publication date:  Jan 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  1  Jesanto Mathew   Chakrakodi Shashidhara Shastry   and Sharad Chand   Introduction: Leucaena leucocephala is a commonly used plant in the Ayurveda system of medicine to alleviate several ailments. Different parts of Leucaena leucocephala are used for the treatment of ailments such as diabetes, ascariasis, intestinal parasitism and trichinosis. It is also used as an emmenagogue, emollient and as nutritious forage for cattle. Objective: This study was conducted to evaluate the plant extract's effect on memory and learning using in-vivo models and ex-vivo models. Methods: The plant extract was prepared by using the Soxhlet extraction procedure. The effect of the extract on nootropic activity was assessed against scopolamine-induced amnesia using different exteroceptive models such as Elevated plus maze, Y maze and Hebb William's maze. Acetylcholinesterase activity of the rat brain homogenate was estimated using Ellman's method. The activity of the extract was compared with the standard drug piracetam. Results: On pre-treatment with ethanolic extract of L. leucocephala, in-vivo studies showed significantly improved spatial learning and memory against scopolamine-induced amnesia in Wistar rat models in a dose-dependent manner. Ex-vivo studies of rat whole brain homogenate showed a significant decrease in acetylcholinesterase activity in extract-treated animals. Conclusion: The ethanolic extract of the leaves of L. leucocephala showed significant nootropic potential against animals induced by amnesia using scopolamine.
      PubDate: Jan 2022
  • In vivo Anticoagulant Activity of Immediate Release Tablets of Dabigatran
           Etexilate Mesylate Cocrystals

    • Abstract: Publication date:  Jan 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  1  Ashwini Gawade   Sanjay Boldhane   Anil Pawar   Rohini Pujari   and Ashwin Kuchekar   Dabigatran Etexilate Mesylate (DEM), a salt of prodrug dabigatran etexilate, is a potent, oral, reversible and direct thrombin inhibitor with low oral bioavailability. The present research investigation focused on the formulation of immediate release (IR) tablets of DEM cocrystals and evaluation of In vivo anticoagulant activity. The results of the study showed that the formulated IR tablets of DEM showed improved efficacy in comparison with the plain drug by enhancing the pre-compression parameters such as bulk density, tap density, Carr's index, angle of repose and Hausner's ratio and post-compression parameters like thickness and weight variation, hardness and friability, In vitro dissolution parameters. The improved efficacy was confirmed by improvement in the pharmacodynamic parameters such as cutaneous bleeding time and clotting time indicative of enhanced bioavailability of dabigatran. Thus, it can be concluded that the IR tablets of dabigatran cocrystals can be proven to be more effective in producing the anticoagulant effect in clinical practice as compared to the plain drug resulting in more patient compliance.
      PubDate: Jan 2022
  • Pharmacognosy and Analytical Specification of Kadarpaasi Chooranam - A
           Novel Siddha Drug

    • Abstract: Publication date:  Apr 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  2  Sabari Anandh J V   Manimekalai K   Rajendra Kumar A   and Bragadeeswaran S   Background: Algae are an excellent wellspring of biologically active secondary metabolites and have been shown to exhibit a wide range of therapeutic properties. Several Asian cultures have a strong tradition of utilizing various seaweeds extensively in cooking as well as in herbal medicines preparations. Their use in traditional medicine has been reported since time immemorial. Aims and Objectives: To evaluate the analytical specification, proximate analysis, and trace elemental analysis of Kadarpassi Chooranam. Methods: Halimeda gracilis (green alga) was collected from the Mandapam region and identified by a marine biologist. Halimeda gracilis was made into chooranam, and it was purified by using the 'Avi Enthiram' method and analytical specification, Proximate analysis, and trace elemental analysis were performed. Results: Kadarpassi Chooranam was standardized as per PLIM guidelines testing protocol, the Heavy metals were found within the normal range, Aflatoxin, Pesticide residues, Organochlorine, Organophosphorus, and Synthetic pyrethroids were found to be below the limit of quantitation (BLQ) and the microbiological test showed free of harmful pathogen. Trace elemental analysis and proximate analysis of Kadarpassi Chooranam showed significant presence, which can be used as health supplements. Conclusion: Kadarpassi Chooranam contains the permissible level of heavy metals, toxins and is free of harmful pathogens. The chemical constituents of the chooranam were characteristically studied, which showed that they contain organic compounds, which may have various pharmacological activities. So, Kadarpassi Chooranam is the first of its kind in the medicinal field. Future studies (in vitro and in vivo) will explore the potential medicinal properties.
      PubDate: Apr 2022
  • Exposition of Protein Kinase Targeted Nanoplatforms: An Extensive Review

    • Abstract: Publication date:  Apr 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  2  J. Josephine Leno Jenita   Jahnavi Kulkarni   Agasa Ramu Mahesh   Shanaz Banu   Seema S. Rathore   and Manjula D   Protein kinases play a prominent role in transferring a phosphate group from ATP (adenosine triphosphate) to serine, tyrosine, or threonine residues. Mutation and dysregulation in their activity lead to an imbalance in the health causing diseases like cancer. Protein kinase inhibitors have proved to be more effective in addressing such impairment caused by the dysregulation of protein kinases. Several protein kinase inhibitors like antibodies and small molecules have been approved by the regulatory bodies like US FDA, and many of them are being developed and expected to enter the clinical trials and subsequently to the market in the near future. However, targeting such kinase inhibitors to the desired site of action remains a challenging process. The current review focuses on the applicability of Nano platforms for targeting protein kinase inhibitors to the desired site of action and thus enhancing the therapeutic efficacy of the drug molecules against cancer. Besides, it also gives a brief idea to the readers about the imaging nanoplatforms investigated for the detection of protein kinase inhibitor activity along with the list of ongoing clinical trials pertaining to protein kinase inhibitors.
      PubDate: Apr 2022
  • Assessment of Analgesic Activity of Two Antihypertensive Drugs

    • Abstract: Publication date:  Apr 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  2  Anbuchellvam   and Jayalakshmi G   Inflammation is an important part of the body's defense system, since it helps to remove and repair damaged tissue as well as neutralize poisonous compounds. The cascade includes increased permeability in microvessels, the attachment of circulating cells to vessels near the damage site, migration of various cell types, and the formation of new tissue and blood vessels. The analgesic and anti-inflammatory effects of rosuvastatin and telmisartan were examined in albino rats and Swiss mice. The hot plate approach regarded licking and leaping as response points. The combo group and rosuvastatin had similar analgesic efficacy. Its analgesic efficacy was significantly lower than that of a normal analgesic aspirin. Telmisartan, too, showed no analgesic effect. In this experiment, the percentage of inhibition at 120 minutes revealed that rosuvastatin and telmisartan given alone had a favourable impact on acute inflammation. Furthermore, the decrease of acute inflammation in the combination group was equivalent to that of aspirin. The data demonstrated that the capacity of the combination group to reduce chronic inflammation is equivalent to that of aspirin as an anti-inflammatory drug.
      PubDate: Apr 2022
  • Green Synthesis of Nanomaterials and Their Utilization as Potential
           Vehicles for Targeted Cancer Drug Delivery

    • Abstract: Publication date:  Apr 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  2  Nisha Khatik   A nanoparticle (NP) is a microscopic particle with a length of two or three dimensions greater than 0.001 micrometer (1 nanometer =10−9 metre). NPs may be classified into different classes based on their specific properties, shapes or sizes, and high surface area-to-volume ratio. Nanoparticles have a remarkable capacity as 'magic bullets' stacked with herbicides, fungicides, supplements, fertilizers or nucleic acids, specializing in expressing plant tissues to deliver their charge to the appropriate piece of the plant to perform desired outcomes. The smart design and synthesis of a library of nanomaterials, exact control over their physicochemical properties and simplicity of their surface functionalization to assemble explicitness is to be certain fundamental for the achievement of disease treatment and harmfulness in the biological systems. Green techniques for nanomaterial synthesis observe natural organic systems to nanomaterial production. Green synthesized nanomaterials are at present powerful and significant tools for protecting the drug from the dangerous surroundings in addition to overcoming the organic obstacles to access of the drug in targeted tissues and dealing with drug resistance. NPs were extensively utilized in numerous biomedical applications, site-specific drug delivery systems and cellular uptake because of their inert nature, stability, high dispersity, non-cytotoxicity, and biocompatibility. Nanoparticles may be programmed for recognizing the cancerous cells and giving selective and correct drug delivery avoiding interaction with the healthy cells. However, usage of those NPs is restrained through factors like lack of stability in adversarial environment, concerns regarding bioaccumulation and toxicity, need of relatively trained employees for device assembly and operation, and problems with reproducibility and affordability.
      PubDate: Apr 2022
  • Molecular Docking Analysis of Human Somatic and Testicular Angiotensin
           Converting Enzyme Complexed with a Novel Compound Gly-Val-Arg

    • Abstract: Publication date:  Apr 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  2  Sivananthan Manoharan   Adawiyah Suriza Shuib   Noorlidah Abdullah   Nor Farrah Wahidah Ridzwan   and Saharuddin Bin Mohamad   Hypertension is one of the most common chronic diseases affecting millions of people worldwide. The structure-based drug design targeting domains of the ACE is important in the treatment of hypertension. The domain specificity inhibition of somatic ACE and testicular ACE by tripeptide GVR by binding to the specified active site of ACE has not been previously described. From this study, it was shown that tripeptide GVR was significantly bound to the active site of the C-domain of somatic ACE as compared to the N-domain. Although tripeptide GVR was mimicking captopril, a strong inhibition of the C-domain's active site and a weak inhibition of the N-domain by GVR probably led to less significant side effects to the patients as compared to the strong non-domain specific inhibitor, captopril. Besides, the ability of tripeptide GVR to strongly inhibit testicular ACE was also shown. From this study, it has been shown that tripeptide GVR was able to bind on both somatic ACE and testicular ACE. It was also shown that the existence of arginine amino acid at the C-terminal of a peptide sequence was essential to inhibit ACE significantly.
      PubDate: Apr 2022
  • In silico Analysis of Selected Phytocompounds of Cocculus hirsutus as
           Potent Inhibitors of Tau Aggregation in Alzheimer's Disease

    • Abstract: Publication date:  Apr 2022
      Source:Advances in Pharmacology and Pharmacy  Volume  10  Number  2  Uma Sankar Gorla   GSN Koteswara Rao   Rajasekhar Reddy Alavala   Ravi Manne   and Kadiyala Harshitha   In the current investigation, the selected phytocompounds of Cocculus hirsutus were screened for potent tau aggregation inhibitors for Alzheimer's disease through in silico molecular docking. Approximately 19 phytocompounds from Cocculus hirsutus were selected and assessed for their drug likeness based on rule-of-five using Swiss ADME. The phytocompounds that passed rule-of-five were subjected to in silico analysis through molecular docking on Cyclin-dependent kinase 5 (CDK5) and Glycogen synthase kinase 3 beta (GSK3B) using Molegro Virtual Docker v6.0. Molecular docking studies. The molecular interaction on CDK5 and GSK3B enzymes indicate their role in the tau protein aggregation inhibitory activity of the phytocompounds. In silico analysis showed that hirsutine and cohirsinine bind effectively at the active site of target proteins with a MolDock score of -115.08 and -107.29 respectively. The MolDock scores, ReRank scores and interaction poses of the phytocompounds were compared with the known inhibitors of CDK5 and GSK3B enzymes. The present research created a new perspective in understanding hirsutine and cohirsinine phytocompounds as effective inhibitors of tau aggregation and further research in vitro and in vivo may confirm their therapeutic potential in Alzheimer's.
      PubDate: Apr 2022
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