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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 27)
AAPS Open     Open Access   (Followers: 5)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 2)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 92)
Advanced Herbal Medicine     Open Access   (Followers: 10)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 13)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 8)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 5)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 4)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 11)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 6)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 6)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 20)
American Journal of Drug Discovery and Development     Open Access   (Followers: 2)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 51)
American Journal of Pharmacological Sciences     Open Access   (Followers: 2)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 21)
American Journal of Therapeutics     Hybrid Journal   (Followers: 11)
Analytical Methods     Hybrid Journal   (Followers: 7)
Annales Pharmaceutiques Francaises     Full-text available via subscription  
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 51)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 26)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 6)
Antibiotics     Open Access   (Followers: 12)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 7)
Applied Clinical Trials     Full-text available via subscription   (Followers: 5)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 1)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Archives of Razi Institute     Open Access   (Followers: 1)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Pharmaceutics     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Pharmaceutical Journal     Full-text available via subscription  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 11)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Bioanalysis     Full-text available via subscription   (Followers: 6)
Biochemical Pharmacology     Hybrid Journal   (Followers: 9)
BioDrugs     Full-text available via subscription   (Followers: 4)
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 1)
Biomarkers in Drug Development     Partially Free   (Followers: 1)
Biomaterials     Hybrid Journal   (Followers: 54)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 1)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 6)
Biopharm International     Full-text available via subscription   (Followers: 8)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 11)
BMC Pharmacology     Open Access   (Followers: 3)
BMC Pharmacology & Toxicology     Open Access   (Followers: 5)
Brazilian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 25)
British Journal of Pharmacology     Hybrid Journal   (Followers: 14)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 1)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 12)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical and Pharmaceutical Bulletin     Full-text available via subscription  
Chemical Research in Toxicology     Hybrid Journal   (Followers: 20)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Ciencia e Investigación     Open Access  
Ciência Equatorial     Open Access  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 3)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access   (Followers: 2)
Clinical Drug Investigation     Full-text available via subscription   (Followers: 6)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 11)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 16)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 31)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 2)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 5)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 5)
Clinical Therapeutics     Hybrid Journal   (Followers: 10)
Clinical Toxicology     Hybrid Journal   (Followers: 17)
Clinical Trials     Hybrid Journal   (Followers: 12)
CNS Drug Reviews     Open Access   (Followers: 3)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 6)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Therapeutic Drug Carrier Systems     Full-text available via subscription  
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 22)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 3)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 5)
Current Drug Metabolism     Hybrid Journal   (Followers: 3)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 2)
Current Drug Therapy     Hybrid Journal   (Followers: 2)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 7)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 4)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 1)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 5)
Current Therapeutic Research     Open Access   (Followers: 5)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 7)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 1)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 3)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 12)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 7)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 1)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 24)
Drug Development Research     Hybrid Journal   (Followers: 8)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 7)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 8)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 3)
Drug Metabolism Letters     Hybrid Journal   (Followers: 2)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 3)
Drug Research     Hybrid Journal   (Followers: 1)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 78)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 8)
Drugs     Full-text available via subscription   (Followers: 139)
Drugs & Aging     Full-text available via subscription   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs and Therapy Studies     Open Access  
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 4)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Egyptian Pharmaceutical Journal     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 2)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 7)
Epilepsy Research     Hybrid Journal   (Followers: 8)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 11)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 5)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 82)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 23)
European Journal of Pharmacology     Hybrid Journal   (Followers: 3)
European Medical, Health and Pharmaceutical Journal     Open Access   (Followers: 2)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 8)
European Pharmaceutical Journal     Open Access  

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Advances in Pharmacology and Pharmacy
Number of Followers: 8  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2332-0036 - ISSN (Online) 2332-0044
Published by Horizon Research Publishing Homepage  [51 journals]
  • Preparation and Characterization of Dapsone Emulgel 7.5% Using Quality by
           Design

    • Abstract: Publication date:  Jan 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  1  Prashant Gajananrao Karamkar   Ashish Agrawal   and Vivekanand Kisan Chatap   The present study work was undertaken with the intent to develop a topical emulgel formulation of dapsone 7.5% which would attenuate the first-pass metabolism associated with an oral administration. Dapsone has low solubility and low permeability and is designated as Biopharmaceutical Classification System (BCS) class-II drug as per the biopharmaceutics classification system. The dapsone is formulated as an emulgel which is premeditated to the application by topical route for the management of the skin disease acne vulgaris. The quality target product profile (QTPP) was defined considering product superiority and efficacy. Critical quality attributes (CQAs) are finished product quality metrics and are identified for process validation. The emulgel formulation containing dapsone was optimized by using a 3-factor, 2-level central composed design (CCD). The concentration of polymer, oil, and surfactant were identified as independent variables and drug release and viscosity were dependent variables, Ultrez 10 with a concentration of 1.25 – 4.5 %, Olive Oil with 7.5 – 20 % as oil phase and tween 80 with 12.5 – 37.5 % as surfactant. The optimization study confirms 20 runs which designate a high level of prognostic skill in response surface methodology. The formulations are characterized by drug content, spreadability, pH, residence time, drug release, and viscosity. From the obtained results of drug release, it was concluded that an optimized formulation shows a complete drug release. An accelerated stability study analysis showed acceptable results for an optimized trial formulation.
      PubDate: Jan 2024
       
  • Pharmacological Evaluation of Moringa oleifera Seeds Extract for
           Anti-Inflammatory Effects in a Mouse Model

    • Abstract: Publication date:  Jan 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  1  Anas Dauda   Abba Mus'ab Usman   Albashir Tahir   Ahmad Muslim Muhammad   Suleiman Yunusa   and Aminu Umar Kura   Inflammation is a common immune response system to obnoxious stimuli like infectious agents, toxic substances injured, cells, or irradiation. However, sustained inflammation can lead to various disease conditions. Therefore, it is important to find ways to counteract or neutralize inflammation. The seeds of Moringa oleifera have been traditionally used for treating several illnesses, but there is a lack of scientific data to evaluate the effectiveness of these practices, thus the aim of this study is to determine whether the methanol extract of Moringa oleifera, obtained through cold maceration, possesses anti-inflammatory activity. The extract effects were assessed using formalin-induced paw edema. Five groups of animals were created, each containing four mice. The groups included a control group (administered normal saline) and a reference group (administered indomethacin). The extract was given at three graded doses; 150, 300, and 600 (mg/kg). Inflammation was induced 30 minutes later by formalin following the extract administration, and measurement of the paw thickness was carried out at 0, 30, 60, and 90 minutes respectively. The results obtained demonstrated a significant reduction in paw thickness at the tested doses. The effect of the extract at 90 minutes was observed to be dose-dependent. This study provides further evidence supporting the traditional medicinal uses of Moringa oleifera seeds.
      PubDate: Jan 2024
       
  • Parabens and Pancreatic Cancer

    • Abstract: Publication date:  Jan 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  1  Lama Alloujami   and Sophie Barguil   Background: Parabens (PBs) are one of the famous substances used as preservatives for a long time. New studies confirmed that PBs had an estrogen-mimicking effect, which may have an abnormal stimulating effect on cell proliferation and induction of cancer occurrence, particularly breast cancer by their binding of estrogen receptors. As known, estrogen receptors (ERs) are not confined to the breast; they are distributed in many parts of the body including pancreas. The purpose of this research is to investigate the presence of the three types of PBs that are currently used: methyl (MP), ethyl (EP), and propyl parabens (PP) in the samples of pancreatic cancer, which is considered one of the most dangerous cancers. Methods: 12 samples of pancreatic cancer were collected immediately after surgery and kept in -80℃ then PBs had been determined in samples by HPLC/MS. Results: All studied samples had PBs with a total mean (318.8±6.4) ng/g. According to the one sample t-test, clear statistical evidence links the presence of parabens in the studied samples and the incidence of pancreatic cancer. EP was the highest one, followed by MP then PP in samples. Conclusions: Since pancreas have estrogen receptors, and PBs mimic estrogen, and estrogen known by its role in pancreatic cancer, PBs which were detected in pancreas studied samples in very high concentration, may have a role in forming pancreatic cancer tumors by binding with estrogen receptors in pancreas. More studies might be done to understand PBs effecting mechanism in pancreas to determine if BPs may have an important effect in incitation abnormal production of these cells similarly as done in breast cancer cells by binding to ERs in these organs.
      PubDate: Jan 2024
       
  • Formulation and In vitro Evaluation of Carica Papaya Topical Gel

    • Abstract: Publication date:  Jan 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  1  Haranath Chinthaginjala   Hindustan Abdul Ahad   Haricharan Kambadur   Naresh Reddy Kamireddy Midde   Rompicharla Narasimha Sai   and Turubilli Satish   Drug delivery through the skin can be used for efficiently treating local dermatological disorders. Topical gel preparations offer an appropriate drug delivery since they are less oily and easily pull away from the skin. Oral delivery has first-pass impacts, gastrointestinal discomfort, and metabolic degradation as negatives. The topical administration of gel formulations has been suggested as a way to get over these obstacles. The current study is concerned with formulation and In vitro evaluation of C. Papaya topical gel. A tropical plant called Carica Papaya [C. Papaya] has been used for a long time to treat a number of illnesses, including inflammatory conditions. Gastrointestinal issues are the NSAIDs' most significant side effects. In an effort to combat this, a topical gel was created utilizing papaya extract, which is known to cure inflammation. Gels are becoming a top-tier material, as a result of its biocompatibility, network topology, and molecular stability of the included bioactive ingredient, employed for drug delivery formulations. Maceration was the process employed to create the C. Papaya extract, and several polymers, including Carbopol 934, xanthan gum, and guar gum, were used in various proportions to develop the topical gel. The topical gel was prepared by using dispersion method. A total number of six formulations were developed employing 1:1 and 1:5 ratios. It appears that there is no interaction between the extract and the formulation's polymers, according to FT-IR measurements. The topical gel's physical characteristics, viscosity, diffusion studies, pH, and spreadability were assessed and were found to be satisfactory. All of the formulations' viscosities were between 32.3 and 36.4 Cps. Among all formulations, formulation F2 containing 1.5% of Carbopol 934 which shows 98.7% of the drug was released, making it the formulation with the greatest chance of success.
      PubDate: Jan 2024
       
  • Implementation and Evaluation of Drug Related Problems in Cardio Vascular
           Patients

    • Abstract: Publication date:  Jan 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  1  Katike Mohammad Umar   and C. Madhavi Latha   Drug-related issues affect patients' quality of life, mortality, and morbidity. At any point during the prescription, transcription, distribution, and administration of drugs, drug-related issues might arise. Investigate the prevalence, forms, patterns, and clinical importance of drug-related issues in cardiovascular patients to enhance patient safety and treatment results. An eight-month prospective interventional study was conducted in the medical and cardiology wards of the tertiary care hospital. Drug interactions, untreated indications, and without an indication were the most often reported drug-related problems (DRPs) in inpatients, while subtherapeutic dosage and overdose were the least frequent DRPs. The results of our study indicate that the clinical chemist plays a critical role in the early detection of DRP and the risk factors associated with it, as well as in the assessment and management of any side effects associated with the use of drugs in cardiovascular patients. None of the patients who completed the questionnaire and responded said they experienced any substantial difficulties with their normal day-to-day activities, according to the study. A total of 138 clinical pharmacist interventions were suggested in this research, of which 101 were approved and 37 were refused. Of these issues, 87 were solved, leaving 51 unsolved. According to the study's conclusions, clinical pharmacy is crucial in the early detection of DRP and its associated risk factors to avoid, evaluate, and control unfavourable drug-related outcomes in cardiovascular patients.
      PubDate: Jan 2024
       
  • Neuroprotective Activity of Olea Europaea and Malus Domestica in Stroke
           Model of Albino Rat

    • Abstract: Publication date:  Jan 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  1  Kanwal Asif   Humaira M Khan   Mahreen Siddique   Tanveer Ahmad Khan   Farah Syed   Humayun Riaz   Syed Atif Raza   Abdul Raheem Malik   and Waqas Ahmad   Stroke is the foremost cause of demise and disability globally. Nevertheless, treatment choices are still inadequate, despite decades of research. The study aimed to assess the neuroprotective effect of Olea europaea (extra virgin olive oil) (EVOE) and Malus domestica (apple cider vinegar) (MD) in the albino rat model of stroke. Their effect on motor and sensory functions (Locomotor asymmetry, forepaw dexterity, contralateral side injury, memory issues, and unilateral deficiency) was measured by cylinder test, pasta test, ladder rung walking test, Morris water maze test, and pole test, respectively. After 21 days of prophylactic dosing, the middle cerebral artery occlusion procedure induced the stroke. After the execution of the animals, 2,3,5 triphenyl tetrazolium chloride (TTC) was used to dye slices of the brain to measure the size of cerebral infarction. EVOE (0.75ml/kg/day) and MD (5ml/kg/day) alone have shown significant neuroprotective potential by improving the findings of the ladder rung walking test (P value < 0.05), pasta test (P value < 0.05), and cylinder test (P value < 0.05) to those fed with the standard dose of Piracetam (250 mg/kg/day). The rats who received EVOE (0.75ml/kg/day) and MD (5ml/kg/day) required less percentage time to reach the hidden maze when compared to rats of the group receiving the standard treatment of Piracetam (P value < 0.05). In the Pole test, mobility duration was significantly reduced by EVOE and MD compared to the treated control group (P value < 0.05). Histopathology showed likewise a significant effect of EVOE and MD on the ischemic part. In conclusion, EVOE and MD have exhibited noteworthy neuroprotective effects.
      PubDate: Jan 2024
       
  • Quantitative Estimation of Secondary Metabolite, In-vitro Antioxidant,
           Anti-Sickling & Anti-Inflammatory Activity by HRBC Membrane Stabilization
           of Ethanolic Extract of Bacopa monnieri (L.) Pennell

    • Abstract: Publication date:  Jan 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  1  Abhishek Kumar Pandey   In India, a wide variety of medicinal plants are reported. Since ancient times, these medicinal plants have been used by people for the treatment of various diseases. The focus of this study is to quantitatively analyze the total phenol, tannin, flavonoid, and alkaloid content, as well as evaluate the in vitro anti-inflammatory activity through HRBC membrane stabilization of the ethanolic extract obtained from Bacopa monnieri [BM]. The plant's antioxidant activity was assessed using the DPPH assay, while its anti-sickling activity was evaluated using the enamel test and the reversibility method. Total phenolic content (TPC) was recorded at 108.76±2.69 µg per mg of gallic acid equivalent. Total tannin content was recorded at 13.49±0.42 µg per mg of gallic acid equivalent. Total flavonoid content was recorded at 191.52±3.90 µg per mg of quercetin equivalent. Bacopa monnieri scavenged 91.24±2.63 % of the DPPH at 75 µg/ml of plant extract. At the same concentrations, the standard drug scavenged 59.14±2.78 % of DPPH. IC50 of plant extract is recorded at 19.23 µg/ml, whereas IC50 of ascorbic acid is recorded at 51.88 µg/ml. The anti-inflammatory activity of plant extract is also dependent on the concentrations. It reduces hemolysis up to 41.5±0.56 % of hemolysis at maximum concentrations, i.e. 2000 µg/ml. At the same concentrations, diclofenac sodium inhibits hemolysis up to 54.55±1.08 %. The reversal rate of the sickle is 81.37±1.25 % with 10mg/ml of Bacopa monnieri extract, while at the same concentrations, standard drug phenylalanine reversed 85.71±1.10 % of sickle cells. The present research shows Bacopa monnieri ethanolic extract has significant anti-oxidant, anti-inflammatory, and anti-sickling activity.
      PubDate: Jan 2024
       
  • Bio-Synthesis, Characterization and Ecotoxicology of Selenium
           Nanoparticles Using Sansevieria cylindrica Bojer Ex Hook Plant Extract

    • Abstract: Publication date:  Jan 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  1  M. Laxmi Kiruthika   E. Shanthi Priya   K. M. Jerun Nisha   D. Sathiya Sheela   and K. Kalimuthu   Anthropological activities release heavy metals like arsenic, zinc, mercury, lead etc. into the environment and produce pollution disturbing the ecosystem. Chemical synthesis of nanoparticles which is used to curb these effects also emits some toxic substances during the synthesis compared to biologically synthesized nanoparticles. Biologically synthesized nanoparticles also have enormous potential and are used against human and plant pathogens, cancer, inflammation etc. Chemically synthesized nanoparticles (NPs) also contribute to heavy metal accumulation (HMA) while bio-synthesized selenium nanoparticles are known to alleviate the heavy metal accumulation. It is notable that the usage of bio-synthesized NPs in agriculture without knowing the accumulation percentage may lead to HMA. In the present study, the SeNPs are bio-synthesized using the Sansevieria cylindrica plant as a capping and reducing agent. The synthesized nanoparticles are tested on earthworms and termites to eliminate the nanoecotoxicology. The colour change of NP solution ranges from pale yellow to brick red, with an absorption range of SCSeNP as 290~300nm in UV-vis spectroscopy. SCSeNPs showed 6 intense peaks in FT-IR analysis and functional groups such as alcohols, phenols, alkynes, 1°amines, aromatics, aliphatic amines and alkyl halides were identified. 7 intense peaks in XRD such as 20.1°, 23°, 23.92°, 24.24°, 27.96°, 27.96° & 29°, presence of Se in EDAX and size of SCSeNP ranges between 117.2 – 192.2 µm obtained through characterization conform to the synthesis. In HMA study through AAS method, 2.0ppm of accumulation range has been obtained. The mortality rate of earthworms was observed in vitro. This proves that this bio-synthesized SCSeNP can be capable to be used in nano drugs and agriproducts like fertilizer, pesticide and so on.
      PubDate: Jan 2024
       
  • Virtual Screening of Active Biomolecules from Plumeria Acutifolia against
           PPAR-γ

    • Abstract: Publication date:  Jan 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  1  Shridhar N Deshpande   Elvita Valentine Gonsalves   Akshay Thomas   Aneesh Jeshan Suares   Charan Kumar K. S.   Jesmitha Queeny Dsouza   Mahendra G. S.   and Revanasiddappa B. C.   Introduction: Thiazolidinediones are widely used synthetic antidiabetic agents. These agents affect the pumping power of heart muscle due to the formation of edema, limiting their usage in patients with congestive heart failure. The current study was aimed to perform in silico docking study of bioactive phytoconstituents from Plumeria acutifolia against the target Peroxisome proliferator-activated gamma (PPAR-γ). Materials and Methods: The docking study was performed by using Schrodinger. The chemical constituents were retrieved from the PubChem database. The pharmacokinetic and toxicological parameters of each compound were predicted using Pre ADMET online server. The drug-likeness character of each compound was predicted using Molsoft. Results and Discussion: Among the five compounds, two compounds scored positive drug-likeness score. Tremuloidin and Plumieride showed the highest binding affinity with the target protein. All the compounds showed the binding affinity with the target protein suggesting that the compounds from Plumeria acutifolia can be utilized to target PPAR-γ in the management of diabetes. The study suggests supporting the current study by performing wet lab experiments. Conclusion: The present study reports the presence of some active biomolecules and also presents the probable PPAR-γ activity via computer simulations.
      PubDate: Jan 2024
       
  • Navigating the Landscape of Alzheimer's Disease: From Epidemiology to Drug
           Re-purposing

    • Abstract: Publication date:  Apr 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  2  Karishma Rathi   Ritesh Bhole   Prachi Bansode   and Nayan Motghare   Alzheimer's disease (AD) is a prevalent and complex neurodegenerative disorder, primarily affecting the elderly population and characterized by cognitive decline. It is primarily diagnosed based on the presence of neurotic plaques and neurofibrillary tangles in the brain. The prevalence of AD is increasing, and existing treatments, such as acetylcholinesterase inhibitors and memantine, aim to alleviate symptoms rather than provide a cure. These treatments have limitations and side effects, leading to the urgent need for innovative therapies. This review discusses the challenges in current AD treatments and explores potential future approaches. Precision medicine, epigenetic interventions, immunotherapy, anti-amyloid and anti-tau agents, and drug repurposing are promising strategies that offer potential benefits in addressing the underlying pathology of AD. Drug repurposing, in particular, is highlighted as a cost-effective and time-saving approach to accelerating drug development. Illustrative examples of repurposed drugs are presented, shedding light on the potential of this strategy to provide effective AD treatments. Moreover, strategies for drug repurposing involve experimental methods like binding assays and phenotypic screening, as well as computational approaches driven by AI. Collaboration among diverse stakeholders and the use of extensive databases enhance repurposing efforts. Examples of repurposed molecules for Alzheimer's disease include anti-diabetic drugs and certain anti-cancer agents, showing potential for AD treatment. Thalidomide's anti-inflammatory properties combat AD-related inflammation. PD-1 blockers like Pembrolizumab activate the immune system against AD. Imatinib shows neuroprotective effects. Antibiotics, antivirals, calcium channel blockers, angiotensin receptor blockers, and erectile dysfunction drugs offer diverse strategies for AD therapy.
      PubDate: Apr 2024
       
  • Design, Development and Optimization of Bixa Orellana Extract Loaded
           Silver Nanoparticle

    • Abstract: Publication date:  Apr 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  2  Swapnil S. Patil   Manojkumar M. Nitalikar   and Preeti khulbe   The current study describes a green method to make silver nanoparticles from bixa orellana extract (BOAgNPs). The application of green synthesis for nanoparticle production is considered advantageous in comparison to alternative synthesis methods due to its environmentally friendly nature and cost-effectiveness. Extraction of Bixa orellana seed was carried out by hot extraction technique. The extract was then utilized to prepare silver nanoparticles. The study aimed to investigate the impact of process variables, specifically the concentration of silver nitrate (AgNO3) and stirring duration, on the particle size and entrapment efficiency of produced BOAgNPs. The ANNOVA of a quadratic model was applied using design expert software to assess the impacts. The optimized BOAgNPs were subjected to characterization using UV and FTIR. The quadratic model provided an optimal batch with a particle size of 88.5 nm and an entrapment efficiency of 95.73%. The observed zeta potential of -35.5 mV indicates that the formulation is likely to exhibit a high level of stability. The analysis of the quadratic model indicates that an increase in string duration results in a significantly increase in particle size. Additionally, an increase in the concentration of AgNO3 leads to an increase in the entrapment efficiency of BOAgNPs. Nanogel of optimized batch of BOAgNPs has evaluated with In vitro anticancer cell line and it reveals moderate activity against B16F10 cell line.
      PubDate: Apr 2024
       
  • Comparative Study of Hepatoprotective and Hematinic Activities of
           Ethanolic Extracts of Flacourtia indica's Leaf and Stem Bark

    • Abstract: Publication date:  Apr 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  2  Idoko A   Firdous S M   Ufedo-Enyo G. Emmanuel   Sofia Khanam   and Ike P O   This study aimed to scrutinize the effect of the ethanol extracts of leaf and stem bark of Flacourtia indica (F. indica) on blood and liver in aluminum chloride (AlCl3) challenged Wistar rats. Twenty-four male Wistar rats, weighing 180-210 g were split into six groups (A-F) [n=6], and treated with AlCl3 (5 days) and extracts (1 week); viz., group A: normal control, group B: AlCl3 (260 mg/kg), group C: AlCl3 (260 mg/kg) + leaf extract of F. indica (500 mg/kg), group D: AlCl3 (260 mg/kg) + leaf extract of F. indica (500 mg/kg), group E: AlCl3 (260 mg/kg) + bark extract of F. indica (625 mg/kg), and group F: AlCl3 (260 mg/kg) + bark extract of F. indica (625 mg/kg). In the severe toxicity study, death was recorded at 3500mg/kg bark extract dose. Animals intoxicated with AlCl3 exhibited a significant rise in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood glucose, and bilirubin (BIL) concentrations; and a decrease in total protein (TP) and albumin (ALB) concentration. Also, a considerable decrease in packed cell volume (PCV) and hemoglobin; and histological artifacts were also remarked in animals intoxicated with AlCl3. Treatment with the leaf and bark extracts of F. indica exhibited a significant reversal of the above said artifacts. The extracts also improved the histological features of the liver. It may be concluded that treatment of the AlCl3 induced anemic and hepatic injured rats with leaf and stem bark F. indica, attenuated these conditions effectively, as evident in the reduced concentrations of liver marker enzymes, and improved the levels of PCV and hemoglobin.
      PubDate: Apr 2024
       
  • Hypo-testicular Efficacy Assessment of H2O-methanol (60:40) Extract of
           Tinospora cordifolia (Willd.) Stem in Albino Rat: A Dose-dependent Study

    • Abstract: Publication date:  Apr 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  2  Puja Das   Dipanwita Mitra   Dibya Pal   and Debidas Ghosh   Background: Tinospora cordifolia (Willd.) Miers. traditionally familiar as giloy or gulancha has been used as a traditional folk medicine in Ayurveda from ancient times due to its antifertility effect. However, the mechanisms behind the hypo-testicular action of this herbal plant remain unclear. In this context, this investigation has been performed to unfold the probable mechanism of action by an effective dose of the H2O-methanol (60:40) extract (HME) of T. cordifolia stem. Objective: To determine the effective dose of T. cordifolia's HME for hypo-testicular efficacy testing in male albino rats. Materials and methods: Doses of T. cordifolia's HME at 5 (low), 10 (moderate), and 20 (high) mg/100 g of body weight (BW)/day for 28 days were given to the experimental rats in three separate dose-treated groups by oral gavage feeding. Rats in the vehicle-treated control group (VTCG) were fed only 0.5 ml sterile water/100 g of BW/day. Spermiological profile, seminal vesicular fructose level, androgenic markers, oxidative stress parameters, and testicular histological studies were analyzed. Results: Different doses of HME-treated groups (HMETGs) delineated a downward deviation significantly (p
      PubDate: Apr 2024
       
  • Simultaneous UV-Visible Spectrophotometric Determination of Nelfinavir and
           Quercetin in Patented Pharmaceutical Formulation and Bulk by First-Order
           Derivative Spectroscopic Method

    • Abstract: Publication date:  Apr 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  2  Sachin Shivling Bhusari   Akshay Ashok Thorat   and Pravin Shridhar Wakte   Aim: To develop and validate a simple, precise, accurate, and sensitive UV-visible spectrophotometric method for the simultaneous estimation of Nelfinavir and Quercetin in patented pharmaceutical formulation and bulk by using a first-order derivative spectroscopic method according to the ICH guidelines. Methods: The zero-order spectra were obtained over the range of 200-400 nm for different concentrations of Nelfinavir and Quercetin, the overlay was converted to the first-order derivative spectra and zero-crossing points were selected as working wavelengths. Multiple calibration standards of both drugs were prepared separately and absorbance values were recorded at respective wavelengths. The proposed analytical method was validated according to ICH guidelines and various parameters viz. accuracy, precision, Limit of Detection, Limit of Quantitation, ruggedness, and robustness were assessed. Results: The zero-crossing points of Nelfinavir and Quercetin were found to be 284 nm and 371 nm respectively. The linearity range was found to be between 10-60 μg/ml for Nelfinavir and 02-10 μg/ml for Quercetin with a correlation coefficient of 0.999. The intra-and inter-day precision study showed a percent relative standard deviation between 0.44-1.44 and 0.21-1.02 respectively. LOD and LOQ of the proposed method were found to be 0.1195 μg/ml and 0.3623 μg/ml for Nelfinavir respectively whereas for Quercetin, said values were 0.0372μg/ml and 0.1129 μg/ml respectively. The total percent recovery of Nelfinavir and Quercetin was found to be in the range of 99.86 to 100.02 and 99.71 to 101.57 respectively. Conclusion: The simple, precise, accurate, and sensitive UV-visible spectrophotometric method for the simultaneous estimation of Nelfinavir and Quercetin in patented pharmaceutical formulation and bulk was developed and validated.
      PubDate: Apr 2024
       
  • Synthesis and In-Vitro Anti Bacterial Activity of (E)-1-(3-oxo-3-(p-tolyl)
           prop-1-en-1-yl)-5,5-Diphenylimidazolidine-2,4-Dione and its Derivatives

    • Abstract: Publication date:  Apr 2024
      Source:Advances in Pharmacology and Pharmacy  Volume  12  Number  2  Rohit Jaysing Bhor   Somnath Wadghane   Girish Kokate   and Mahesh H Kolhe   Introduction: 5, 5-diphenylimidazolidine is a heterocyclic hydrocarbon with distinctive basic structural properties in its molecular structure. A novel series of (E)-1-(3-oxo-3-(p-tolyl)prop-1-en-1-yl)-5,5-diphenylimidazolidine-2,4-dione and its derivatives were created by treating different1-acetyl-5,5-diphenylimidazolidine-2,4-dione (0.025 mol) with an equimolar quantity of 4-methyl benzaldehyde. Methods: The structure of synthesised compounds was confirmed using FTIR, NMR spectroscopy, and MS. The agar dilution method was used to test the title compounds and their derivatives for in vitro antibacterial activities against various human pathogenic microorganisms. Ciprofloxacin was used as the standard medication. All of the title compounds were active against some strains of microorganism. According to structural activity connection research, compounds with an electron-withdrawing group have higher activity than compounds with electron-donating groups. Results: Based on the results obtained, when compared to common medicines like Ciprofloxacin; the compounds 4-(2,4-dioxo-5,5-diphenylimidazolidin-1-yl)-4-oxobutanoic acid (SW1)(E)-1-(3-oxo-3-(p-tolyl)prop-1-en-1-yl)-5,5-diphenylimidazolidine-2,4-dione (SW2)(E)-1-(3-oxo-3-(p-tolyl)prop-1-en-1-yl)-5,5-diphenylimidazolidine-2,4-dione (SW3) showed good significant activity. Conclusion: The antibacterial activity of the title compounds and their derivatives was examined. According to structural activity relationship studies, compounds containing 5, 5-diphenylimidazolidine derivatives with an electron-withdrawing group perform better than compounds with electron-donating groups. Table 3 shows the preliminary antimicrobial testing findings of the produced compounds, including the usual broad spectrum antibacterial medication Ciprofloxacin. The synthetic compounds have been evaluated for their capacity to inhibit (E)-1-(3-oxo-3-(p-tolyl)prop-1-en-1-yl) and their antibacterial activity. Derivatives of -5,5-diphenylimidazolidine-2,4-dione (SW2) have significant antibacterial action.
      PubDate: Apr 2024
       
  • Comparison of Propolis Containing Dentifrice Versus Commercially Available
           Dentifrice in Gingivitis Treatment: A Randomized Double-Blinded Clinical
           Trial

    • Abstract: Publication date:  Oct 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  4  Gautami S. Penmetsa   Gangolu Meghana   Mohan Kumar P.   NVS Sruthima   Ramesh KSV   and Mohana Kondapally   Aim and Objective: In spite of its multifaceted qualities, propolis, a herbal remedy that has been used extensively in traditional medicine since the beginning of time, appears to be an interesting addition to topical applications. As an active agent, propolis, when used in various forms such as varnishes, mouthwashes, has been found beneficial in reducing gingivitis, oral mucosal lesions, and oral ulcerations. Therefore, the purpose of the current study is to compare how well commercially available dentifrice and dentifrice containing propolis are at preventing gingivitis. Materials and Methods: For the intervention, two distinct types of paste (Propolis and Colgate) were used on forty participants with mild to moderate gingivitis who were between the ages of 20 and 35. Plaque index (Silness and Loe 1964), gingival index (Loe and Silness 1963), and bleeding scores (Muhlemann and Sons 1971) were recorded at baseline and the 30th day. Results: No statistically significant differences were seen in the intergroup, whereas statistically significant differences (p≤0.05) were observed in the intragroup comparison between baseline and one month. Conclusions: Both the dentifrices were equally effective in reducing clinical parameters.
      PubDate: Oct 2023
       
  • Phytochemicals, In Vitro Antidiabetic (IVAD) and Anti-inflammatory (IVAI)
           Studies of Aerial Part and Root Peel of Raphanus sativus L.

    • Abstract: Publication date:  Oct 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  4  Thiyagarajan Bharathi   Ganesan Janani   Manokaran Saravanan   and Rajangam Udayakumar   Raphanus sativus was selected for this study to analyze phytochemicals, IVAD and IVAI activities. The fresh plant of Raphanus sativus was collected and cleaned with pure water. The aerial part and root peel were separated and then dried under shade. The dried plant samples were ground well into powder. About 100 g of dry powder was extracted with solvents ethanol, methanol and benzene by soxhlet apparatus. The extracts were filtered and kept in oven at 40℃ to evaporate the solvent completely from it. Dark brown residues were obtained and kept in air tight containers separately at 4℃ until the time of use. The aerial part and root peel extracts of Raphanus sativus were used for the evaluation of phytochemicals, IVAD and IVAI activities. The phytochemical screening of extracts revealed the presence of phenolic compounds, flavonoids, alkaloids, etc. The ethanolic, methanolic and benzene extracts of aerial part of Raphanus sativus showed IVAD activity as 75.17 ± 3.60%, 71.70 ± 3.47% and 72.61 ± 3.66%, respectively at 250 μg/ml of concentration. The ethanolic, methanolic and benzene extracts of root peel of Raphanus sativus showed IVAD activity as 78.61 ± 3.62%, 72.73 ± 2.45% and 71.50 ± 3.75%, respectively at 250 μg/ml of concentration. The IVAI activity was observed in ethanolic, methanolic and benzene extracts of root peel of Raphanus sativus as 83.87 ± 3.55%, 61.82 ± 3.47% and 67.87 ± 3.75%, respectively and the aerial part showed as 82.79 ± 3.65%, 53.97 ± 3.43% and 57.95 ± 3.47%, respectively at 200 μg/ml of concentration. All the tested extracts were exhibited IVAD and IVAI activities as like as reference drugs acarbose and diclofenac sodium, respectively. So, the results suggest that the aerial part and root peel of Raphanus sativus possess phytocompounds, IVAD and IVAI activities.
      PubDate: Oct 2023
       
  • Evaluation of Phytochemical and In Vitro Anti-inflammatory and Antioxidant
           Potential of Ocimum americanum L. Leaf

    • Abstract: Publication date:  Oct 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  4  Abhishek Kumar Pandey   and Preeti Pandey   In the present scenario, none of the impactful drugs is available to treat inflammation and oxidative stress without any side effects. We focused on the Ocimum americanum leaf and evaluated its phytochemical composition, anti-inflammatory properties, and antioxidant potential using an ethanolic extraction method. A spectrophotometer was used to measure the leaf extract's overall phenolic content (TPC), whole tannin content (TTC), and the total amount of flavonoid (TFC). The human red blood cell (HRBC) membrane stabilisation method was used to evaluate the extract's anti-inflammatory properties, and the, -diphenyl--picrylhydrazyl (DPPH) method was used to test its antioxidant capacity. We discovered that the TPC, TTC, and TFC values for the plant extract were 131.44 g of GAE/mg, 13.7 g/GAE mg, and 164.7 g of QE/mg, respectively. With a maximal inhibition of 89.79% at a concentration of 1000 g/ml, the extract demonstrated considerable anti-inflammatory efficacy that was comparable to that of the common medicine diclofenac sodium. The extract's capacity to scavenge DPPH was likewise superior to that of the ascorbic acid standard medication, with 96.32% scavenging being seen at the highest concentration (75 g/ml). The extract from the leaf IC50 value was 13.82±2.44 µg/ml, which was one-fourth that of ascorbic acid (51.88±3.24 µg/ml). Our results indicate that the O. americanum leaf extract has the potential to effectively treat inflammation and oxidative stress, and any useful compounds extracted from this plant could be utilized for this purpose in the future.
      PubDate: Oct 2023
       
  • Design, Evaluation and Optimization of L-carnitine as Floating
           Microspheres for Hyperlipidemia Using 23 Full Factorial Design

    • Abstract: Publication date:  Oct 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  4  Anusha B.   Ashwini R.   Sakthikumar C.   Darshan Chhajed D.   Darshan Palavalli   Seema S. Rathore   and J. Josephine Leno Jenita   L-Carnitine is a non-essential amino acid and is used as an anti-lipidemic agent with bioavailability<18% when administered orally. A floating system for L-Carnitine was designed to increase the duration it spends in the stomach without coming in contact with the mucosa by solvent evaporation method. 23 full factorial design model was applied to obtain the experimental runs. The Polymer concentration, stirring rate and stirring time were the constraints of independent variables used to generate the eight experimental runs and were characterized for % yield, in-vitro buoyancy and drug loading. The optimized formulation was studied for its surface morphology, x-ray diffraction, zeta potential and in-vitro release kinetic studies. The formulated microspheres were spherical and free-flowing. They had particle size ranging from 45.75 to 54.79 μm which was suitable for oral delivery. The % yield ranged from 75 to 87.5% and all the microspheres were floating for more than 24hrs. Ethyl cellulose played an important role as a polymer to achieve the buoyancy and to produce gastric retention of drug. The results suggest that L-carnitine as floating microspheres provides controlled drug delivery for the treatment of hyperlipidemia and also improves the bioavailability.
      PubDate: Oct 2023
       
  • Investigating the Anti-Obesity Potential of Crataegus azarolus and Acer
           syriacum

    • Abstract: Publication date:  Oct 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  4  Ream Nayal   Angela Espir   and Mohammad Y. Abajy   Obesity is a global issue and can predispose to metabolic diseases such as, type 2 diabetes, atherosclerosis and cardiovascular disease. One of the therapeutic strategies in managing obesity is the inhibition of pancreatic lipase. In this study, the inhibitory activity of different polar extracts of C. azarolus and A. syriacum on porcine pancreatic lipase was evaluated in vitro. Results showed that the best inhibitory activity was for C. azarolus hydroethanolic extract (IC50 =0.204 mg/ml). Therefore, the antiobesity effect of this extract was studied by using wistar rats that had been obese due to a high-fat diet. Oral treatment with 400mg/kg (body weight) of this extract for 6 weeks resulted in body weight reduction similar (p>0.05) to orlistat group (the positive control). Moreover, the ethanol extract decreased significantly the visceral adipose, adiposity index and liver weight in treated group compared to the high-fat control group (p
      PubDate: Oct 2023
       
  • Synthesis of Zinc Oxide Nanoparticles using Centella asiatica

    • Abstract: Publication date:  Oct 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  4  Richa Sood   Darshitha   Agasa Ramu Mahesh   Seema S. Rathore   and Josephine Leno Jenita   Nanoparticles of zinc oxide have received huge recognition credits due to unique properties, such as small size, large surface area, optical properties, and morphology. The plant centric approach using several parts and their extracts, is believed to be a recent technique which is simple and an economical strategy in synthesizing metal nanoparticles. This article relates to an easily approachable, environmentally safe and economical technique for synthesizing zinc oxide nanoparticles (ZnO NPs) from the extract of leaves of Centella asiatica. The zinc oxide nanoparticles synthesized were characterized subsequently by Ultraviolet Visible spectroscopy, X-ray diffraction spectroscopy (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Analysis (EDX) and Dynamic Light Scattering (DLS) methods. The absorption peak was obtained at 327nm, which indicates formation of ZnO Nanoparticles. The mean particle size and zeta potential were found to be 173.2 and -12.8mV. The X-ray diffraction showed well defined peak characteristic of the nanoparticles. The elemental composition of both Oxygen (O) and Zinc (Zn) was found in the sample with weight percentages 31% and 69% successively; and atomic percentages 64.74% and 35.26%. The surface morphology was estimated by SEM, and it was observed that the particles are almost spherical in shape.
      PubDate: Oct 2023
       
  • Assay of Nutritional and Therapeutic Values, Using Physicochemical
           Parameters and Antimicrobial Activity of Leaf and Bark of Erinocarpus
           nimmonii Grah. ex Dalz., an Endemic Species

    • Abstract: Publication date:  Oct 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  4  Anitha Puranik   and T. C. Taranath   The leaf and bark of Erinocarpus nimmonii Grah. ex Dalz., a monotypic, endemic medicinal plant of Malvaceae, were assayed for i) nutritional (proximate, total energy, and minerals) and therapeutic (extractive values, swelling, and foaming index) values using physicochemical parameters, ii) presence of saponin, using Froth Test and Fourier Transform Infrared (FTIR) spectral means, and iii) antimicrobial activity of sequential solvent extracts and minimum inhibitory concentration (MIC) by agar well diffusion and agar dilution methods, respectively. The rich nutritional and mineral value, foaming (saponin), swelling index (mucilage) and maximum soluble extractive values in water and ethanol (SMs) depicted the high nutritional and therapeutic values. Among all sequential extracts, the froth test positively responded to the polar methanol and aqueous extracts, and the FTIR data further validated this finding. The antimicrobial activity showed the highest inhibitory effect of methanol and aqueous extracts towards different clinical isolates like Acinetobacter baumannii and other pathogens, and the bark extracts showed stronger inhibitory effects than the leaf, which may be correlated to the high saponin content of polar extracts and bark, along with other antimicrobial principles. Consequently, the results proved the efficacious therapy for nosocomial infections and ventilator-associated pneumonia-causing A. baumannii (MIC of 0.078 mg/ml). The documented physicochemical parameters assist in maintaining the efficacy and purity of the drug and also recommend its use as a low-cost source of protein and therapeutic drug after further research.
      PubDate: Oct 2023
       
  • The Anticonvulsant Potential of Boswellia dalzielii in Mice – Pilot
           Study

    • Abstract: Publication date:  Oct 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  4  Albashir Tahir   Hauwau Abubakar   Aminu Umar Kura   Suleiman Yunusa   and Yahaya M Katagum   The use of plants in traditional medicine entails the use of many substances in the cure of both chronic diseases as well as some acute infectious diseases. Herbal medicine is one of the oldest forms of healthcare known to mankind and has been an integral part of healthcare for many centuries, with many people depending on it as their primary form of treatment. Boswellia dalzielii is a plant belonging to the family Burseraceae, which has been widely used in African traditional medicine and was locally reported to have a wide array of medicinal values in folk medicine. The aim of this study is to assess the anticonvulsant potential of the methanolic stem bark extract of Boswellia dalzielii in mice. Phytochemical screening, acute toxicity studies were carried out. The result of the phytochemical screening of the methanol stem bark extract indicated the presence of alkaloids, glycosides, steroids, flavonoids and saponins, and the oral acute toxicity dose was found to be greater than 2000 mg/kg. The extract was tested for anticonvulsant activity against pentylenetetrazole, and strychnine-induced seizures at 100, 200, and 300 mg/kg doses in Swiss albino mice. The extract was observed to significantly (p
      PubDate: Oct 2023
       
  • Phytochemical Screening and Bioactive Potential of Shoot Tip Exudate of
           Gardenia Resinifera

    • Abstract: Publication date:  Jul 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  3  Sithara K. Urumbil   Leenitha M.   Jasmin Maria E. J.   and Sherin K. B.   Gardenia resinifera is a well-known medicinal plant with key contributions in healthcare systems. The qualitative phytochemical analysis of shoot tip exudate of Gardenia resinifera Roth. showed occurrence of bioactive compounds with substantial applications in drug development. Ascertainment of various phytochemical constituents indicated the presence of flavonoids, phenolic compounds, terpenoids, triterpenoids, resins, proteins, amino acids, phlobatannins, phytosterols, quinones, coumarins and gums. Anti-microbial studies using selected pathogenic bacterial and fungal strains showed its ability to prevent microbial growth in agar well diffusion plate. Shoot tip exudate of Gardenia resinifera showed anti-bacterial property against Bacillus subtilis and Staphylococcus aureus. The shoot tip exudate was more effective as anti-bacterial agents than anti-fungal agents. The free radical scavenging activity of shoot tip exudate was analyzed in detail for evaluating the antioxidant potential. Their extracts were analysed using the following assays like 2,2-di-phenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity assay and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonicacid (ABTS) radical cation-based assay which showed percentage inhibition of 93.75±0.52 (1000µg/ml) and 32.62±0.42 (100µg/ml) respectively. The study was based on exudation from shoot tip as a promising source of novel antioxidant without causing any apparent destruction to plant tissues. Plant exudations can be considered as a promising path to be followed for research for the identification of valuable bioresources with great therapeutic value.
      PubDate: Jul 2023
       
  • GC-MS Profiling of Bioactive Compounds of Methanolic Leaf Extract of
           Tephrosia Strigosa (Dalzell) Santapau & Maheshw. of Indian Thar Desert

    • Abstract: Publication date:  Jul 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  3  Vandana   Ilham Bano   Vinod Deora   and G S Deora   Tephrosia strigosa of family Fabaceae is an annual herbaceous plant growing in the rocky habitat of the Indian Thar desert. In this study, leaves of T.strigosa were screened for the identification of phytochemical compounds. Preliminary phytochemical screening was carried out on methanolic leaf extract to find out the primary and secondary phytochemical compounds. The secondary metabolites present in methanolic leaf extract were identified by gas chromatography-mass spectroscopy technique. Preliminary phytochemical screening confirmed the presence of primary and secondary metabolites such as carbohydrates, amino acids, phenols, alkaloids, terpenes, flavonoids, phytosterols, glycosides, saponin and fatty acids. GC-MS analysis revealed a total of 55 phytochemical compounds, out of which 52 were identified. Many significant compounds like 2-Methoxy-4-vinyl phenol, Benzofuran, Naphthalene, Neophytadiene, Phytol, Piperidine, Squalene, Lupeol, Hexadecanoic acid and Octadecanoic acid, etc., were reported in methanolic leaf extract. The extract was found rich in terpene compounds. Isolation of various bioactive compounds of T. strigosa can provide an opportunity to develop novel herbal drugs to cure various diseases with fewer side effects.
      PubDate: Jul 2023
       
  • Antiarthritic and Antioxidant Potential of Ethanolic Unripened Fruit
           Extract of Luffa Acutangula (L.) Roxb Against FCA-induced Arthritic Rats

    • Abstract: Publication date:  Jul 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  3  Lalitha Vivekanandan   Shila Gunasekaran   Sethumathi Ponnusamy   and Prabha Thangavel   Background: Chronic autoimmune illness rheumatoid arthritis (RA) mostly affects joints and other organs. Free radicals are the main etiology to induce arthritis by increasing the inflammatory mediator's release. The currently available anti-arthritic drugs showed gastrointestinal discomfort, nephrotoxicity, and increased cardiovascular complications due to their long-term use. The herbal drugs have been safe, cheap, and effective against RA. The unripened fruits of Luffa acutangula (LA) or ridged gourd (Family: Cucurbitaceae) are used as an edible vegetable and are reported as a laxative, diuretic, antiseptic, anti-inflammatory, etc. Objective: The present research determined the antiarthritic and antioxidant potential of ethanolic unripened fruit extract of Luffa acultangula (EFLA) against FCA (Complete Freund's Adjuvant) induced arthritic rats. Methods: The subplantar region of rats was treated with single subcutaneous administration of FCA for induction of arthritis. The EFLA at doses of 200, 400 mg/kg/PO, and the Dexamethasone 5 mg/kg/PO were administered from the 16th to the 30th day after FCA induction. The total flavonoid and phenolic content were measured by the colorimetric method. Paw edema, arthritic score, hematological parameters, markers for liver and renal function, C-reactive protein (CRP), rheumatoid factor (RF), and markers for oxidative stress were all measured. Results: The total flavonoid content was 0.94±0.02 GAE/g and the total phenolic content was 0.72±0.04 mg of QE/g, respectively. The EFLA significantly attenuated paw swelling, arthritic score, hematological alterations, CRP, RF factor, and free radicals-induced damage. Conclusion: EFLA is a feasible therapeutic drug for the remedy of RA for long-term use because it is an antioxidant-rich edible fruit. Further research is needed to find prophylactic actions and adjuvant therapy of LA against RA.
      PubDate: Jul 2023
       
  • Potentiation of Pindolol on Venlafaxine in Balb/c Mice Exposed to Chronic
           Mild Stress

    • Abstract: Publication date:  Jul 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  3  Burak Yaman   In this research, it is aimed to determine the potentiation of pindolol on the antidepressant effect of venlafaxine in psychomotor agitated depressed mice exposed to chronic mild stress by using open field test and measurement of defecation score. Psychomotor agitated depression model was created by a modified chronic mild stress protocol inspired by previous studies where chronic mild stress was used to provide a depression model in mice. Antidepressant effects of the drugs were tested by measurement of transition to the center area, time in the center area and defecation score of mice in open field test. Chronic mild stress caused to increase in the transition frequency to the center area, in the time to be in the center area, and in the defecation score, markers of the psychomotor agitation and depression (p
      PubDate: Jul 2023
       
  • Medicinal Benefits of Black Rice (Oryza Sativa L. Indica): A Review

    • Abstract: Publication date:  Jul 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  3  Sakshi Bhardwaj   Dhanashree Javere   Pradnya Bagad   Likhit Akotkar   Vivekanad Chatap   and Urmila Aswar   Black rice (Oryza sativa L. indica) is also called purple rice (gluten free rice), emperor's rice (tribute food) and king's rice. It is abundantly grown worldwide, specifically in Asian countries such as Bangladesh, China, Japan, Sri Lanka, Indonesia, and Thailand. In India, it is majorly found in north-eastern states, including Meghalaya, Assam, and Manipur, which are the cultivators of black rice. It is also considered a superfood owing to its potent antioxidant activity which mediates numerous health-beneficial effects with anticancer, anti-inflammatory, immunomodulatory and anti-allergic characteristics. Black rice has a high nutritional value due to its rich source of various vitamins (A, B, E), amino acids and lipids, dietary fibre. The presence of the flavonoid plant pigment anthocyanin contributes to its purple-black colour and strong antioxidant properties. Other components like manganese and calcium support a healthy metabolism and stronger bones. Black rice is getting popularized in recent times because of its very low toxicity and higher nutritional qualities. This review focuses on the nutritional composition, toxicity, pharmacological uses and future opportunities of black rice for better health and well-being.
      PubDate: Jul 2023
       
  • Fabrication and Characterization of Curcumin-loaded Gelatin Nanoparticle
           Using A Two-Step Desolvation Protocol

    • Abstract: Publication date:  Jul 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  3  Prashant B Patil   Darshan D. Mahale   Bhushan K. Marathe   Kiran P. Sinkar   Dilip A. Patil   Jayvadan K. Patel   and Zamir G. Khan   Recently gelatin nanoparticles (G-NPs) have been gaining substantial consideration because they offer excellent properties like low cost, biocompatibility, and biodegradability. One of the protein materials that can be utilized to make nanoparticles is gelatin. The emphasis is constructed on the datum that gelatin is non-toxic, easy to crosslink, and chemically changeable, and hence consumes a gigantic potential for colloidal drug delivery system synthesis. The surface of G-NPs can be easily cat-ionized with a variety of amine derivatives to provide targeted and sustained drug delivery. Curcumin-loaded gelatin G-NPs were manufactured using a two-step desolvation progression in this study. A glutaraldehyde cross-linker was also employed to provide G-NP with good stability. Inclusive, the ordinary size of the curcumin-loaded gelatin (CGNPs) was 112 nm, with a zeta potential of +31.80 mV. An In-vitro dissolution study confirmed 88 % of the drug was released from the CGNP within 24 h. In comparison, drug release showed a lower release rate, at about 66 % after 24 h. In the present work, we fabricated a curcumin-loaded gelatin nanoparticle to improve the solubility and thereby enhance the stability of a formulation, which will further encourage the progress of curcumin based on nanoformulation. Curcumin-loaded gelatin nanoparticles have a higher stability in biological fluids than colloidal carriers, allowing for the desired delimited and unrelenting release of encapsulated drug molecules. In all, the fabricated curcumin-loaded gelatin nanoparticle proved to be a sustained-release drug delivery system.
      PubDate: Jul 2023
       
  • Antioxidant, Anti-Microbial, Anti-Inflammatory and Cytotoxic Effect of
           Macrotyloma Uniflorum Leaf Extract

    • Abstract: Publication date:  Jul 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  3  Arun Kumar Kashyap   Padmini Bisoyi   and Buddhi Prakash Jain   Macrotyloma uniflorum (Horse gram), a legume plant with medicinal properties is used as a tonic, diuretic and in the treatment of rheumatism and neurological disorders. The present study was undertaken to find the anti-microbial, anti-inflammatory, the antioxidant, and cytotoxic activity of leaf extract of Macrotyloma uniflorum. Extract of the Macrotyloma uniflorum leaf was prepared in the hexane, ethyl acetate, methanol solvent and analyzed for phytochemicals composition. Total flavonoid and phenolic contents, antioxidants, and free radical scavenging capacity were determined and found to be high in methanolic and ethyl acetate extract compared to the Hexane extract. The methanolic extract showed higher anti-microbial activity and anti-inflammatory activity. Methanolic extract of Macrotyloma uniflorum leaf has the anti-microbial, antioxidant, and anti-inflammatory properties. The leaf extract of the Macrotyloma uniflorum also shows cytotoxic effects in breast cancer cell line (MCF-7) in a dose dependent manner which was further confirmed by FACS analysis. This study highlights the potential of the methanolic extract of leaves of Macrotyloma uniflorum -as an antioxidant, anti-inflammatory, cytotoxic and anti-microbial agent.
      PubDate: Jul 2023
       
  • Evaluation of Phytochemicals, Anti-inflammatory and Antioxidant Potential
           of Aegle marmelos L. Leaves

    • Abstract: Publication date:  Jan 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  1  Abhishek Kumar Pandey   and Preeti Pande   Aegle marmelos is a deciduous tree with trifoliate leave commonly found in the Indian subcontinent. The present study is to diagnose the phytochemicals physiochemical, qualitative and quantitative estimation. Total phenolic content was recorded at 53.52±3.25 µg Gallic acid equivalent (GAE) /mg of plant extract, total tannin content was observed at 6.4±1.02 μg GAE/mg and total flavonoid content was recorded at 37.4±2.65 μg Quercetin equivalent/mg. The study also comprised the Anti-inflammatory and anti-oxidant activity of plant leaves. Anti-inflammatory activity was examined through the HRBC method and compared with the standard drug diclofenac sodium. Ethanolic extract of leaves shows significant anti-inflammatory activity and provides 61.04±2.89 % of protection against hemolysis at 2000µg/ml of leave extract whereas at the same concentration diclofenac sodium provides only 54.55±2.35 % protection against hemolysis. The antioxidant potential of plant extract examines through DPPH free radical scavenging method. Leave extract showed better antioxidant activity in comparison to ascorbic acid. IC50 of plant extract is 48.99 ±1.96 % which is also better than the value of IC50 of ascorbic acid which was recorded at 50.39±2.05. The study showed that leaves extract of the plant has significant potential for the treatment of oxidative stress and inflammation.
      PubDate: Jan 2023
       
  • In vitro Anti-inflammatory, Anti-diabetic and Anticancer Properties of
           

    • Abstract: Publication date:  Jan 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  1  K. Bhuvaneswari   KM Jerun Nisha   K. Kalimuthu   M. Lakxmi Kiruthika   E. Shanthi Priya   and Sathiya Sheela D.   Introduction: The present study focuses on the use of Leucas aspera aqueous extract as a reduction agent for the synthesis of copper nanoparticles (CuNPs). The entire plant is employed in conventional medicine and as an insecticide. Scientific research has been done on the plant's potential as an anti-inflammatory, analgesic, and wound-healing agent. Intoxication by cobra venom also makes use of it. This study was intended to explore the in vitro anti-inflammatory, antidiabetic and anticancer activities of copper nanoparticles. Methods: Protein denaturation and membrane stabilization of human red blood cells (HRBC) were used to assess the in vitro anti-inflammatory activity. The antidiabetic activity of the CuNPs was evaluated by inhibiting both amylase and glucosidase in vitro, whereas anticancer activity against vero and MCF-7 cell line. Results: The Leucas aspera copper nanoparticles (LACuNPs) showed a dose dependent -inflammatory activity. The highest inhibition percentage in protein denaturation is 70.30±1.72% and 67.68±1.41% in HRBC membrane stabilization at 1000µg/ml concentration. In vitro antidiabetic activity exhibited 76.03 ± 1.14 of α-amylase and 71.54 ± 1.55 at α-glucosidase inhibition assay. The in vitro anti-cancer study revealed 50% apoptosis (IC50) of LACuNPs treated vero and MCF7 are displayed as 248.84±0.01 µg/ml and 137.39±1.51, respectively. Conclusion: The results clearly demonstrated the application of biosynthesized LACuNPs as potential anti-inflammatory, anti-diabetic, and anticancer agents in addition to their environmental friendliness.
      PubDate: Jan 2023
       
  • Synthesis and Anti Convulsant Activity of
           "N'-{4-[2-(1h-Benzimidazol-2-Yl)-2-Oxoethyl]
           Phenyl}-2-Hydroxyacetohydrazide and Its Derivatives"

    • Abstract: Publication date:  Jan 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  1  Rohit Jaysing Bhor   Komal Sakharam Sable   Mayur Shivaji Bhosale   and Santosh Bhausaheb Dighe   Introduction: Benzimidazole is a heterocyclic hydrocarbon having unique basic structural characteristics in their structure. This moiety was formed by using aromatic benzene and imidazole heterocylic ring. This molecule gives great application in biological and clinical studies. Benzimidazole and its derivatives have versatile Nitrogen containing heterocyclic compounds that give a promising category of biologically active compounds and possess a wide selection of biological activities like antibacterial drug, medicament, anti-ulcer, anti-diabetic, etc. Objective: Several scientists have declared that benzimidazole system possesses the variable sites like the position of a pair and five which might be fittingly changed to yield potent therapeutic agents. The current review covers the chemistry and medicine activities of substituted benzimidazoles. Materials & Methods: Formic acid; Acetyl Chloride; Hydrazine; Benzene-1,2-diol; Glycolic Acid; Benzoyl Chloride; Methyl Chloride; Ethyl Chloride; Benzamide etc. and methods are TLC, IR spectra, 1H-NMR and MS. Results & Conclusion: The pharmacological screening was done by using PTZ Induced Convulsion Method for anticonvulsant activity. The synthesize compounds were established to be BA to BK. The compound BA, BC, BJ, BI and BK were established to be the most potent compound through the comparison with standard drugs phenytoin. Synthesized newer benzimidazole derivatives were screened for Anti-convulsant activity. It was seen that in biological activity, derivatives containing 2-nitro aniline and 3-nitro aniline have more significant biological activities than other benzimidazole derivatives. Total 11 compounds (4 Step Products + 7 Benzimidazole Derivatives) were evaluated for their biological screening.
      PubDate: Jan 2023
       
  • Applications of Carbon Dots (CDs) in Drug Delivery

    • Abstract: Publication date:  Jan 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  1  Jahasultana Mohammed   Prasanna Kumar Desu   J. Risy Namratha   and GSN Koteswara Rao   The star of the carbon nanomaterials industry is now carbon dots (C-Dots). C-Dots are a potential tool because of their applications in imaging, environmental, catalytic, biological, and energy fields thanks to their numerous distinctive physicochemical and photochemical characteristics. C-Dots have received plenty of research attention and have shown remarkable application growth to date. Green biomass or sustainable raw materials may be used to create C-Dots since they are economical, cost-effective, and most significantly, they encourage waste reduction. However, there is still a problem that must be solved regarding the production of high-quality C-Dots from biomass waste. Chemotherapy is currently recognized as the most successful way of cancer treatment, although it is known to induce severe side effects in patients due to its non-discriminatory harmful impact on both normal and tumor cells. The fundamental issue in cancer and other complicated disorders of chemotherapy is understanding drug distribution throughout organs and designing a site-specific drug delivery method that targets cancer cells. Therefore, it is of crucial importance to create advanced routes for the targeted and traceable administration of anti-cancer drugs. C-Dots can be produced using top-down or bottom-up approaches, with the latter method being more frequently employed for high-volume and low-cost syntheses. In this comprehensive review article, we mainly discuss the structure of CDs, classification of CDs, their properties, limitations, source of CDs, fabrication techniques, and characterization techniques. More significantly, we bring readers update on the most recent trends of CDs development in health care.
      PubDate: Jan 2023
       
  • Haldina cordifolia (Roxb.) Ridsdale Bark Derived Synthesis and
           Characterization of Silver Nanoparticles: Investigation of its
           Antituberculosis and Anticancer Activity

    • Abstract: Publication date:  Jan 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  1  Sneha Desai K   Tarikere C.   and Taranath   Nanotechnology is a rapidly growing field of medical research that may be used to a broad array of applications. Further, phytoconstituents are a promising possibility for the production of silver nanoparticles (AgNPs). AgNPs were biosynthesized using Haldina cordifolia bark extract and further characterization was done using UV-Vis Spectrophotometer, FTIR, XRD, DLS, Zeta potential and HR-TEM with SAED. The cytotoxic effect on lung cancer cell lines (A549) of AgNPs was studied by MTT assay and its antituberculosis activity was evaluated by MABA assay. The result showed that the AgNPs synthesized using bark extract of Haldina cordifolia have reported visible reddish-brown color and the absorption peak at 408nm (pH 10.5). FTIR confirmed the plant secondary metabolites that helped in green synthesis and capping of AgNPs. XRD revealed the crystalline nature of AgNPs. Zeta potential showed the stability at -42mV. HR-TEM and DLS images of AgNPs indicated the size ranged from 7 to 57nm. The dose response dependent anticancer activity was observed with IC50 value 17.64 µg/ml on A549 cell line which was more efficient than plant extract (IC50=79.92 µg/ml). On the other hand, AgNPs also showed promising antituberculosis activity with the MIC 0.4 µg/ml which was higher than the standard drugs used for comparison. We conclude that Haldina cordifolia is considered as an effective reducing and capping agent for green synthesis of AgNPs. Phytosynthesized AgNPs may subsequently be potential chemopreventive agent against the cancer treatment and as antituberculosis agent in future.
      PubDate: Jan 2023
       
  • Emerging Drug Delivery System: An Enormous Trust for the Treatment of
           Diabetes Mellitus

    • Abstract: Publication date:  Jan 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  1  Manoj Singh   Vikas Kumar   Nisha Devi   Shivani Gupta   Mayank Raj   Sushil Kr Upadhyay   Vanita Thakur   Mukesh Yadav   and Nirmala Sehrawat   Diabetes mellitus (DM) and its coupled comorbidities are a metabolic disorder that is highly prevalent and occurs in the body with high complexity of optimizing increase in glycaemic control because of decreased insulin activity or its low secretion. However, healthcare professionals have been going through the challenge of the mounting plethora of accessible healing options for minimizing hyperglycaemia. This has brought up a challenge responsible for creating difficulties in treating patients with therapeutic inertia. DM has basically been categorized into three sub-types, TYPE I DM, TYPE 2 DM and Gestational diabetes (GD). As TYPE I DM is usually treated through insulin replacement therapy, TYPE 2 DM is treated with various drugs. The highly effective drug therapy for TYPE 2 DM comprises many drugs such as Biguanides, Sulfonylureas, Thiazolidinedione, DDP-4, Alpha-glucosidase inhibitor, Combination therapy and GD treated with oral drugs. The combination therapy has been developed for those patients who cannot achieve routine therapeutic goals. In spite of the significant therapeutic profit, the conventional method has portrayed differential bioavailability and a short half-life period of the desired drug. The uses of such methods have greater side effects persisting with therapy ineffectiveness and patient non-compliance. Given the pathological complexity of the said DM, alternative approaches such as natural polyphenols and nanotechnology-based therapies are getting noticed, which certainly adds certain benefits for site-specific drug delivery with elevated bioavailability and reduced dosage regimen.
      PubDate: Jan 2023
       
  • Formulation and Biological Evaluation of Quorum Sensing Inhibitor-Based
           Nanoemulsion against Resistant Pseudomonal Infections

    • Abstract: Publication date:  Jan 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  1  Snigdha Bhardwaj   and Sonam Bhatia   Antimicrobial resistance has raised a serious concern due to the lack of therapeutics to control pathogenic infections. Pseudomonas aeruginosa is considered a multidrug-resistant pathogen and a leading cause of hospital-acquired infections. Anti-virulence approach mainly focuses on targeting bacterial virulence despite its growth and proves effective against such drug-resistant pathogens. In this study, we select a novel flavonoid compound, 7,8-dihydroxyflavone (DHF), which has been reported as a quorum sensing inhibitor (QSI) of P. aeruginosa, performed its in-silico studies to observe its binding affinity and potential interactions with the target protein (2UV0) and further developed it as a nano drug formulation (DHF-NF), and performed its in-vitro and in-vivo evaluation. The prepared DHF-NF was examined for its efficacy in the prevention of wound-associated surface infections of P. aeruginosa in rats. The DHF-NF was prepared by using homogenization and examined for several physical parameters. The prepared DHF-NF had a spherical shape and smooth topology. The microbiological assays demonstrated the inhibitory potential of DHF-NF in a dose-dependent manner. The histological analysis of Pseudomonas infected tissue of rat skin showed significant activity in animal group treated with DHF-NF as compared to control groups. The microbiological and in-vivo evaluation results revealed that the compound, DHF, showed strong inhibitory potential and suggest that the DHF-NF could be utilized as novel anti-QS and anti-biofilm therapeutics against Pseudomonal surface infections.
      PubDate: Jan 2023
       
  • Preparation, Characterization and In-vitro Evaluation of Gamma Oryzanol
           Loaded Self-nanoemulsifying Drug Delivery Systems

    • Abstract: Publication date:  Apr 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  2  Sandip Badadhe   Gurdeeep Singh   and Neetesh Jain   The Gamma Oryzanol (GOZ), the concept of biopharmaceutical classification systems (BCS), methods for enhancement of solubility and bioavailability, gamma oryzanol have been used for a number of applications, especially due to strong antioxidant activity and lipid-lowering properties. As gamma oryzanol has many therapeutic effects, it can be beneficial for the pharmaceutical industry. But the use of gamma oryzanol in clinical and functional meals systems may be restrained due to low water solubility, poor bioavailability and fast metabolism of gamma oryzanol. -Oryzanol is insoluble in water. Numerous methods of solubilizing complex for cosmetic, pharmaceutical, food uses have been defined. Based totally on initial showing of changed dropped SNEDDS formula, eight components of GOZ stacked SNEEDS have been organized utilizing Capryol 90, Labrasol and Transcutol HP as oil, surfactant as well as cosurfactant, separately. Some of the extraordinary surfactants screened, Labrasol confirmed exceptional solubilizing capability for GOZ (94.69±1.04 mg/mL). On one hundred fold dilution, the percentage transmittance of GOZ SNEDDS formula was observed to be among 97.87% ± 0.30% and 99.57% ± 0.06%. From droplet size analysis, it was seen that GOZ loaded SNEDDS formulation had the mean particle size in the range of 15.03±0.18 to 22.97±0.44 nm indicating their efficiency as SNEDDS. Visual perception showed that there was no stage partition or any flocculation in all formulations and the actual appearance of all plans in underlying one hour of in vitro discharge research, just 12.23% ± 0.45% as well as 42.33% ± 2.78% of GOZ was dissolved after pure drug as well as advertised tablets correspondingly.
      PubDate: Apr 2023
       
  • HPLC Profile, Anticancer, Anti-inflammatory and Antioxidant Activities of
           Euphorbia inarticulata Ethanolic Extract

    • Abstract: Publication date:  Apr 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  2  Abdullah A. A. Alghamdi   Nada M. Ali   Mohammad Mahboob Alam   Syed Nazreen   and Ali Mahzari   Antioxidants, in addition to protection against oxidative stress, also possess anti-inflammatory and anticancer potentials. In this work, the ethanolic extract (EE) of Euphorbia inarticulata has been evaluated for antioxidant, anti-inflammatory and anticancer activities. The antioxidant activity showed that EE significantly scavenges DPPH (IC50 = 54.56 ± 2.38 µg/ml) and H2O2(77.44 ± 2.76 µg/ml), whereas ferric reducing antioxidant power (FRAP) and total antioxidant capacity (TAC) were found to be 100.93 ± 4.15 µg/ml and 46.72 ± 3.86 mg gallic acid equi/gm, respectively. The EE exhibited significant inhibition on COX-1 (IC50 79.84µg/ml) and protein denaturation (IC5057.6 µg/ml), compared to indomethacin and diclofenac, respectively. Furthermore, EE was found to be effective in killing Huh-7 and HeLa cancerous cells with IC50 104.62 (SI 2.36) and 145.11 µg/ml (SI 1.7), respectively, while doxorubicin displayed IC50 0.71 (Huh-7) and 2.63 µg/ml (HeLa), whereas it was safe on normal MRC-5 cells. The HPLC analysis showed the presence of ellagic acid, caffeic acid, gallic acid, syringic acid, cinnamic acid and catechol which may be responsible for the promising antioxidant, anti-inflammatory and anticancer potentials exerted by the ethanolic extract of E. inarticulata. These results conclude that Euphorbia inarticulata ethanolic extract has anti-inflammatory and anticancer effects by triggering oxidative stress.
      PubDate: Apr 2023
       
  • Pharmacological and Nutritional Properties: Genus Salvia

    • Abstract: Publication date:  Apr 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  2  Imran Uysal   Oğuzhan Koçer   Falah Saleh Mohammed   Ömer Lekesiz   Mehmet Doğan   Ali Erdem Şabik   Emre Sevindik   Filiz Özbas Gerçeker   and Mustafa Sevindik   Complementary medicine has emerged with the history of humanity and has become widespread with the use of natural products in the treatment of many diseases. People have used many plant species in the treatment of diseases by benefiting from trial and error and knowledge. Plants have been used as shelter, food, medicine, spices, cosmetics, and tools for use in religious rituals. Different communities around the world have widely used local plants. In addition, the cosmopolitan species are used by all people in the treatment of diseases. Genus Salvia is a plant species that is widely known and used worldwide for its nutritional properties as well as its many biological activities. There are many secondary metabolites in different parts of the plant. Thanks to these secondary metabolites, it shows different biological properties. Salvia species have remarkable activities such as antioxidant, antimicrobial, anticancer. It is also an important natural resource with its high nutritional content. In this study, the nutritional contents, usage areas, chemical compositions and pharmacological properties of Genus Salvia were reviewed. In this context, the use of Salvia species in pharmacological designs and their nutritional importance were emphasized. As a result, it has been determined that members of Genus Salvia are one of the important plant species used in complementary medicine.
      PubDate: Apr 2023
       
  • Novel Approach Self Nanoemulsifying Drug Delivery System: A Review

    • Abstract: Publication date:  Apr 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  2  Jyotsana Suyal   Bhavna Kumar   and Vikas Jakhmola   The self-nanoemulsifying drug delivery system is solitarily the most frequent dosage form for administering drug molecules towards the target region in the pharmaceutical industry. It has gotten a lot of interest in the current scenario because of its budding applications in various industries. In the pharmaceutical business, self-nanoemulsifying drug delivery systems have been used to distribute medications via oral, topical, and parenteral routes. SNEDDS are submicron-sized emulsions being researched as drug carriers to improve therapeutic agent delivery. Due to their tiny droplets, elevated solubility ability, broad interfacial region, reduced consistency, transparent or semi-transparent emergence, & remarkable kinetic constancy, self-nanoemulsifying medicines are meant for an extensive choice of application. Through a combination of a water-insoluble lipid phase with a high-stress aqueous phase, these emulsions may be manufactured in huge quantities quickly. These are created using surfactants, co-surfactants, and co-solvents. In BCS class II and IV drugs, the self-nanoemulsifying drug delivery system is useful in favor of increasing the water solubility of water-soluble pharmaceuticals. In this review, various aspects of the self-nanoemulsifying drug delivery system are highlighted, including method of preparation, characterization techniques such as particle size, zeta potential, polydispersity, drug content, advantages, disadvantages, and a particular importance on various applications of SNEDDS in different areas, such as cancer treatment, drug targeting, and as a vehicle for transdermal drug delivery.
      PubDate: Apr 2023
       
  • Review on Nanosuspension as a Novel Method for Solubility and
           Bioavailability Enhancement of Poorly Soluble Drugs

    • Abstract: Publication date:  Apr 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  2  Shivraj Popat Jadhav   Santosh Kumar Singh   and Himmat Singh Chawra   The formulation development of a drug is majorly based on the solubility of drugs. Nearly 40% of newly developed drugs show poor water solubility. Several approaches are used for the increasing solubility of such drugs for formulation development. Nanosuspension is one such attractive tactic which can be used for the enhancement of solubility, stability as well as bioavailability of such drugs. Nanosuspension can be defined as a two-phasic dosage form where solid drug particles of size less than 1 μm are dispersed in an aqueous phase with the help of a stabilizer. Particle size reduction in the nanoscale causes an increase in the surface area leading to an increase in dissolution rate and ultimately bioavailability is increased. A variety of excipients are used for the formulation of nanosuspension. Stabilizers, surfactants, co-surfactants, natural as well as organic solvents, buffers, salts, polyols, osmogents, and cryoprotectants are used in the formulation of nanosuspension. Various methods used in the formulation of nanosuspension can be classified into top-down and bottom-up approaches. Wet milling, high-pressure homogenization, anti-solvent techniques, melt emulsification, supercritical fluid extraction and ultrasonic homogenization are some of the methods for the preparation of nanosuspension. These methods are easy and appropriate for all poor water-soluble drugs. Nanosuspensions technology can be applied for the preparation of oral, pulmonary, injectable, ocular as well as targeted drug delivery. This review emphasizes various advantages and disadvantages of nanosuspension, its methods of preparation, formulation approaches, evaluation parameters, pharmaceutical applications, marketed products and patents of nanosuspension.
      PubDate: Apr 2023
       
  • Application of 32 Factorial Design in Formulation and Evaluation of
           Olmesartan Medoxomil Floating Microsponges

    • Abstract: Publication date:  Apr 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  2  Hajra Parveen   Vanitha Kondi   and Ramesh Alluri   The goal of the research was to formulate floating microsponges of Olmesartan medoxomil by 32 factorial design to enhance bioavailability in the gastric region. The quasi-emulsion solvent diffusion method was used to prepare gastroretentive floating microsponges. In this study, the concentration of Eudragit L-100 (X1) and the concentration of polyvinyl alcohol (PVA) (X2) were chosen as independent factors at three distinct levels using Design-Expert® software (trial version 13.1.0, Stat-Ease). The dependent variables chosen were the % Buoyancy (Y1) and % cumulative drug release (Y2). The percent yield, particle size, bulk density, % buoyancy, % entrapment efficiency, in vitro drug release, the kinetics of drug release, variation of the model, Fourier Transform Infrared Spectroscopy (FTIR) studies, and stability studies for the optimized formulation were conducted. From the design expert, the optimized formula was found to be OLM-MSG7. The magnitude of the coefficient of both X1 and X2 showed a positive effect on the buoyancy of the floating microsponges. As the concentration of eudragit L-100, the buoyancy of the microsponges increased. The reason for the buoyancy due to the high concentration of eudragit L-100 may be attributed to the low density of the polymer. However, an antagonistic linear effect of PVA was observed. X1 and X2 i.e., polymer concentration and PVA had a positive effect on % CDR of microsponges which indicates that the higher amount of eudragit L-100 contributes to an increase in % CDR. FTIR studies show there is no chemical interaction between the drug and the polymer in the formulation.
      PubDate: Apr 2023
       
  • A Review Article: Formulation of Topical Gel by QbD Approach

    • Abstract: Publication date:  Apr 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  2  Prashant Gajananrao Karamkar   Ashish Agrawal   and Vivekanand Kisan Chatap   Application of drug by topical route is an alternate route for the treatment of skin diseases for systemic route. The skin diseases can be treated by administration of drug by local application and may avoid first pass metabolism. It minimizes systemic side effects and when applied locally can be removed easily if any side effects occur like, irritation, skin rash, redness at the application site. The topical drug delivery has been beneficial for longer period of time because of availability of large surface area of skin which exposed to circulatory routes. Because of this route, one can be directly applied to any external body surface and it is only for local application. Amongst many types of topical dosage form delivery, gel is most likely to be used and is a patient-friendly dosage form. Due to the lack of insoluble excipients and oily bases, the gel represents better release of drug as compared to other topical drug delivery system. Nowadays, many industries follow QbD (Quality by Design) approach for the formulation of Gel to prepare a quality medicine delivery to patients. The QbD approach describes the CQA, CMA and CPP of the formulation which ensures the quality of dosage form. This review article focuses on the different dosage forms, types of gel, evaluation by taking parameters such as drug content, pH, spreadability, extrudability, viscosity, swelling index and in-vitro drug diffusion and application of QbD approach to gel formulation.
      PubDate: Apr 2023
       
  • Roles of Nutraceuticals in Regulating Neurotransmitters in Dementia

    • Abstract: Publication date:  Apr 2023
      Source:Advances in Pharmacology and Pharmacy  Volume  11  Number  2  Nur Faeqah Furairah Othman   Gurmeet Kaur Surindar Singh   and Nurul Aqmar Mohamad Nor Hazalin   Dementia has become one of the most significant public health and economic burdens. Due to the absence of a cure for dementia, the public health priority has focused more recently on the intervention that may help to improve cognitive performance in older age or at least delay the onset of dementia. Recently, nutraceuticals have displayed the ability and strong potential to act as neuroprotectants and/or delay cognitive impairment through various neuroprotective mechanisms. The present study aimed to review scientifically the potential of nutraceuticals in preventing and/or restoring cognitive function and highlights their possible mechanisms and evidence mainly through the modulation of neurotransmitters. Online literature databases such as PubMed and Science Direct were used to search related articles. Current evidence revealed that nutraceuticals like choline, iron, galantamine, omega-3, luteolin, theanine, some vitamins, and probiotics showed better neuroprotective activity against cognitive impairment and dementia. The neuroprotective activity of these nutraceuticals is associated with their ability in regulating neurotransmitters, including inhibiting the reuptake enzymes of neurotransmitters, up-regulating the receptor level, and becoming the precursors of neurotransmitters, thus enabling neurotransmission to occur. Hence, this review would aid the researcher and common people in better understanding the mechanisms and choosing better nutraceuticals to combat cognitive decline and dementia.
      PubDate: Apr 2023
       
 
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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 27)
AAPS Open     Open Access   (Followers: 5)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 2)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 92)
Advanced Herbal Medicine     Open Access   (Followers: 10)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 13)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 8)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 5)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 4)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 11)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 6)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 6)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 20)
American Journal of Drug Discovery and Development     Open Access   (Followers: 2)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 51)
American Journal of Pharmacological Sciences     Open Access   (Followers: 2)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 21)
American Journal of Therapeutics     Hybrid Journal   (Followers: 11)
Analytical Methods     Hybrid Journal   (Followers: 7)
Annales Pharmaceutiques Francaises     Full-text available via subscription  
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 51)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 26)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 6)
Antibiotics     Open Access   (Followers: 12)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 7)
Applied Clinical Trials     Full-text available via subscription   (Followers: 5)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 1)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Archives of Razi Institute     Open Access   (Followers: 1)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Pharmaceutics     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Pharmaceutical Journal     Full-text available via subscription  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 11)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Bioanalysis     Full-text available via subscription   (Followers: 6)
Biochemical Pharmacology     Hybrid Journal   (Followers: 9)
BioDrugs     Full-text available via subscription   (Followers: 4)
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 1)
Biomarkers in Drug Development     Partially Free   (Followers: 1)
Biomaterials     Hybrid Journal   (Followers: 54)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 1)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 6)
Biopharm International     Full-text available via subscription   (Followers: 8)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 11)
BMC Pharmacology     Open Access   (Followers: 3)
BMC Pharmacology & Toxicology     Open Access   (Followers: 5)
Brazilian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 25)
British Journal of Pharmacology     Hybrid Journal   (Followers: 14)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 1)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 12)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical and Pharmaceutical Bulletin     Full-text available via subscription  
Chemical Research in Toxicology     Hybrid Journal   (Followers: 20)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Ciencia e Investigación     Open Access  
Ciência Equatorial     Open Access  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 3)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access   (Followers: 2)
Clinical Drug Investigation     Full-text available via subscription   (Followers: 6)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 11)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 16)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 31)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 2)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 5)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 5)
Clinical Therapeutics     Hybrid Journal   (Followers: 10)
Clinical Toxicology     Hybrid Journal   (Followers: 17)
Clinical Trials     Hybrid Journal   (Followers: 12)
CNS Drug Reviews     Open Access   (Followers: 3)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 6)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Therapeutic Drug Carrier Systems     Full-text available via subscription  
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 22)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 3)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 5)
Current Drug Metabolism     Hybrid Journal   (Followers: 3)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 2)
Current Drug Therapy     Hybrid Journal   (Followers: 2)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 7)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 4)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 1)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 5)
Current Therapeutic Research     Open Access   (Followers: 5)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 7)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 1)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 3)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 12)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 7)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 1)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 24)
Drug Development Research     Hybrid Journal   (Followers: 8)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 7)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 8)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 3)
Drug Metabolism Letters     Hybrid Journal   (Followers: 2)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 3)
Drug Research     Hybrid Journal   (Followers: 1)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 78)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 8)
Drugs     Full-text available via subscription   (Followers: 139)
Drugs & Aging     Full-text available via subscription   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs and Therapy Studies     Open Access  
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 4)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Egyptian Pharmaceutical Journal     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 2)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 7)
Epilepsy Research     Hybrid Journal   (Followers: 8)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 11)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 5)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 82)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 23)
European Journal of Pharmacology     Hybrid Journal   (Followers: 3)
European Medical, Health and Pharmaceutical Journal     Open Access   (Followers: 2)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 8)
European Pharmaceutical Journal     Open Access  

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JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


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