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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 25)
AAPS Open     Open Access   (Followers: 5)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 3)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 94)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 9)
Advances in Pharmacology     Full-text available via subscription   (Followers: 17)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 5)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 5)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 8)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 9)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 19)
American Journal of Drug Discovery and Development     Open Access   (Followers: 3)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 54)
American Journal of Pharmacological Sciences     Open Access   (Followers: 1)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 23)
American Journal of Therapeutics     Hybrid Journal   (Followers: 13)
Analytical Methods     Hybrid Journal   (Followers: 8)
Annales Pharmaceutiques Francaises     Full-text available via subscription  
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 56)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 37)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 5)
Antibiotics     Open Access   (Followers: 11)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 8)
Applied Clinical Trials     Full-text available via subscription   (Followers: 7)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 2)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 1)
Archives of Razi Institute     Open Access  
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Pharmaceutics     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Pharmaceutical Journal     Full-text available via subscription  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 14)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Bioanalysis     Full-text available via subscription   (Followers: 11)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
BioDrugs     Full-text available via subscription   (Followers: 8)
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 3)
Biomarkers in Drug Development     Partially Free   (Followers: 2)
Biomaterials     Hybrid Journal   (Followers: 55)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 1)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 9)
Biopharm International     Full-text available via subscription   (Followers: 20)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 10)
BMC Pharmacology     Open Access   (Followers: 2)
BMC Pharmacology & Toxicology     Open Access   (Followers: 8)
Brazilian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 30)
British Journal of Pharmacology     Hybrid Journal   (Followers: 17)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 2)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical and Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 1)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 22)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Ciencia e Investigación     Open Access  
Ciência Equatorial     Open Access  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 7)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access  
Clinical Drug Investigation     Full-text available via subscription   (Followers: 8)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 12)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 28)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 45)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 4)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 6)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 12)
Clinical Therapeutics     Hybrid Journal   (Followers: 34)
Clinical Toxicology     Hybrid Journal   (Followers: 18)
Clinical Trials     Hybrid Journal   (Followers: 18)
CNS Drug Reviews     Open Access   (Followers: 4)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 11)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Therapeutic Drug Carrier Systems     Full-text available via subscription   (Followers: 5)
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 25)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 4)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 6)
Current Drug Metabolism     Hybrid Journal   (Followers: 5)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 5)
Current Drug Therapy     Hybrid Journal   (Followers: 3)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 13)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 9)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 10)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 11)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 2)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 1)
Current Therapeutic Research     Open Access   (Followers: 6)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 8)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 4)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 5)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 13)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 8)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 3)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 29)
Drug Development Research     Hybrid Journal   (Followers: 11)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 12)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 13)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 6)
Drug Metabolism Letters     Hybrid Journal   (Followers: 3)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 8)
Drug Research     Hybrid Journal   (Followers: 3)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 79)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 10)
Drugs     Full-text available via subscription   (Followers: 135)
Drugs & Aging     Full-text available via subscription   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs and Therapy Studies     Open Access  
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 8)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Egyptian Pharmaceutical Journal     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access  
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 9)
Epilepsy Research     Hybrid Journal   (Followers: 7)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 14)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 8)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 85)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 34)
European Journal of Pharmacology     Hybrid Journal   (Followers: 8)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 9)
European Review for Medical and Pharmacological Sciences     Full-text available via subscription   (Followers: 1)
Experimental and Clinical Psychopharmacology     Full-text available via subscription   (Followers: 7)
Expert Opinion on Drug Delivery     Hybrid Journal   (Followers: 17)
Expert Opinion on Drug Discovery     Hybrid Journal   (Followers: 18)

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Tropical Journal of Pharmaceutical Research
Journal Prestige (SJR): 0.256
Citation Impact (citeScore): 1
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1596-5996
Published by African Journals Online Homepage  [261 journals]
  • MFAP2 contributes to the proliferation and motility of lung cancer cells
           via Wnt/β-catenin pathway

    • Authors: Xiuyun He, Yunfeng Qiao
      Pages: 915 - 920
      Abstract: Purpose: To measure microfibrillar-associated protein 2 (MFAP2) expression levels in lung cancer and identify its role in lung cancer.
      Methods: Immunoblots and PCR were used to determine the expression of MFAP2 in lung cancer cell lines. The effects of MFAP2 on the viability and apoptosis of lung cancer cells were evaluated by CCK-8, colony formation, and flow cytometry (FCM) assays, while wound healing and Transwell assays were used to assess the effects of MFAP2 on the motility and epithelial-mesenchymal transition (EMT) of lung cancer cells. Immunoblot assays were also performed to determine the effect of MFAP2 on the Wnt/β-catenin axis in lung cancer cells.
      Results: MFAP2 was highly expressed in lung cancer cells. Depletion of MFAP2 suppressed the viability and stimulated apoptosis in these cells (p < 0.01). In addition, knockdown of MFAP2 suppressed the motility and EMT of lung cancer cells (p < 0.01). MFAP2 mediated the Wnt/β-catenin axis and affected the viability and motility of lung cancer cells.
      Conclusion: MFAP2 is a promising target for lung cancer treatment.
      PubDate: 2022-06-16
      DOI: 10.4314/tjpr.v21i5.1
      Issue No: Vol. 21, No. 5 (2022)
       
  • Peiminine regulates the biological characteristics of colorectal cancer
           cells via P13K/Akt/mTOR and oxidative stress pathways

    • Authors: GuiLin Jin, Zhen Luo, Mingke Fen, Lijun Xu
      Pages: 921 - 925
      Abstract: Purpose: To investigate the influence of peiminine on biological characteristics of colorectal cancer cells, and the underlying mechanism.
      Methods: Two groups of cultured human colorectal cancer HCT-116 cells were used: peiminine and control groups. Peiminine group cells were exposed to the drug at a final concentration of 100 μmol/L. The effect of peiminine on cell proliferation was determined with CCK-8 method, while its effect on apoptosis was determined with flow cytometric method. Cell migration was determined with scratch test. The effect of peiminine on the expressions of proteins associated with the P13K/Akt/mTOR pathway and Wnt/β-catenin pathway in HCT-116 cells was determined with Western blotting assay.
      Results: Cell proliferation was markedly reduced in the peiminine group, relative to control (p < 0.05). There was higher percentage cell apoptosis in peiminine-treated cells than in control. Moreover, cell migration potential was significantly lower in the peiminine-treated cells. There were significantly downregulated levels of p-P13K, p-Akt and p-mTOR expressions in peiminine group, relative to the corresponding control expressions (p < 0.05). However, there were significantly higher relative expression of Wnt in peiminine group than in control cells, but β-catenin level was reduced, relative to the corresponding control level (p < 0.05).
      Conclusion: These data indicate that peiminine suppresses the proliferative, apoptotic and migratory potential of colorectal carcinoma HCT-116 cells via regulation of P13K/Akt/mTOR and oxidative stress pathways.
      PubDate: 2022-06-16
      DOI: 10.4314/tjpr.v21i5.2
      Issue No: Vol. 21, No. 5 (2022)
       
  • TWIST1 silencing attenuates intracranial aneurysms by inhibiting
           NF-κB signaling

    • Authors: Deng Wang, Dan Lai, Chengfu Peng
      Pages: 927 - 932
      Abstract: Purpose: To investigate the effect of Twist family basic helix-loop-helix transcription factor 1 (TWIST1) on intracranial aneurysms.
      Methods: A rat model of intracranial aneurysm was established by ligating the posterior branches of both the renal and left common carotid arteries. Pathological changes in the intracranial arterial wall were investigated using hematoxylin-eosin staining. TWIST1 expression was assessed using quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot, while vascular smooth muscle cell apoptosis was investigated by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining. Inflammation was evaluated using enzyme-linked immunosorbent assay (ELISA).
      Results: Rats with intracranial aneurysms had degenerative changes in vessel wall structure. In
      intracranial aneurysm rats, TWIST1 was upregulated in arterial wall sections, and TWIST1 knockdown ameliorated the pathological changes to the arterial wall. TWIST1 silencing reduced serum tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) levels and suppressed vascular smooth muscle cell apoptosis in rats with intracranial aneurysms. TWIST1 knockdown increased phospho (p)-inhibitor of nuclear factor-κB (IκB) and decreased IκB and p-p65 in intracranial aneurysm rat arterial wall sections.
      Conclusion: In intracranial aneurysms, silencing TWIST1 promoted vascular remodeling and suppresses vascular smooth muscle cell apoptosis and inflammation through inactivating NF-κB
      signaling, revealing TWIST1 silencing as a potential treatment strategy.
      PubDate: 2022-06-16
      DOI: 10.4314/tjpr.v21i5.3
      Issue No: Vol. 21, No. 5 (2022)
       
  • Myrcene exerts anti-tumor effects on oral cancer cells in vitro via
           induction of apoptosis

    • Authors: Zexiu Wu, Zhenmei Li, Yuan Liang
      Pages: 933 - 938
      Abstract: Purpose: To investigate the anticancer potential of myrcene against oral cancer cells.
      Methods: The effect of myrcene on oral cancer cell growth were studied using CCK-8 proliferation and
      clonogenic assays, while Annexin V-FITC/PI and DAPI staining methods were used for the determination of its effect on cell apoptosis. Protein expression levels were assayed by western blotting technique. Wound healing and Transwell chamber assays were used to determine the effect of myrcene on oral cancer cell migration and invasion, respectively.
      Results: Myrcene significantly and dose-dependently inhibited oral cancer cell growth (p < 0.05). The anti-proliferative effect of myrcene was comparatively lower on Hs27 human fibroblast cells than on SCC9 oral cancer cells. Myrcene stimulated apoptosis in human oral cancer cells via enhancement of Bax expression and repression of Bcl-2 expression. The percentage of early and late apoptotic cells increased from 4.03 in untreated control to 27.77 when treated with 20 μM myrcene. Moreover, myrcene in vitro significantly suppressed the migration and invasion of oral cancer cells (p < 0.05).
      Conclusion: These results indicate that myrcene exerts potent anticancer effects on oral cancer cells via induction of apoptosis, and should be further investigated in vivo for this purpose.
      PubDate: 2022-06-16
      DOI: 10.4314/tjpr.v21i5.4
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effect of beraprost sodium on renal function and p38MAPK signaling pathway
           in rats with diabetic nephropathy

    • Authors: Liangxiao Xie, Jiajia Dong, Jinzhi Wu, Changshun Wei, Kezhen Xu, Pengbin Lai, Xiaoyun Zha
      Pages: 939 - 942
      Abstract: Purpose: To investigate the effect of beraprost sodium (BPS) on renal function and P38MAPK pathway in diabetic nephropathy (DN) rats.
      Methods: Sprague Dawley (SD) rats (n = 30) were randomly divided into three groups, viz, normal control (NC), diabetic nephropathy (DN) and beraprost sodium (BPS). Creatinine (Cr), blood urea nitrogen (BUN) and fasting blood glucose (FBG), were determined by Hitachi 7020 automatic biochemical analyzer, while low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and total cholesterol (TC) were measured by Olympus 400 automatic biochemical analyzer. Western blot analysis was performed to examine protein expression. Interleukin-6 (IL-6), hs-CRP, and TNF-α levels were evaluated using enzyme linked immunosorbent assay (ELISA).
      Results: After 8 weeks of treatment, renal function indices (urine output, KW/BW, UAlb/24 h, Cr and BUN), blood lipid indices (FBG, LDL-C, TG and TC) and inflammatory factors levels (IL-6, hs-CRP and TNF-α) in DN group were higher than NC group (p < 0.05). In BPS group, renal function and blood lipid indices and inflammatory factor levels decreased when compared to DN group (p < 0.05). Furthermore, BPS inhibited the protein expression of p-P38MAPK, TGF-β1 and COX-2.
      Conclusion: Beraprost sodium improves renal function in DN rats by inhibiting P38MAPK signaling
      pathway.
      PubDate: 2022-06-16
      DOI: 10.4314/tjpr.v21i5.5
      Issue No: Vol. 21, No. 5 (2022)
       
  • Glycitin exerts anticancer effect on human lung cancer cells through
           induction of apoptosis, cell cycle arrest, and inhibition of PI3K/AKT
           signal pathway

    • Authors: Yajuan Zhang, Rui Guo, Yan Wang
      Pages: 943 - 950
      Abstract: Purpose: To determine the effect of glycitin on PI3K/AKT signaling, migration, invasion, apoptosis, and cell cycle in A549 lung cancer cells.
      Methods: 3-[4,5-Dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and clonogenic assays were used to determine the proliferation and colony generation potency of A549 cells, respectively, after treatment with glycitin (0 - 120 μM). Apoptosis in A549 cells was measured using DAPI and Annexin V/PI-FITC assays. Cell cycle arrest was assessed byflow cytometry, while the effect of glycitin on migration and invasion of A549 cells was determined by Transwell assay. The effect of glycitin on expressions of proteins associated with PI3K/AKT signaling in A549 cells was measured using western blotting.
      Results: Glycitin significantly inhibited the proliferation and colony generation potential of A549 cells (p < 0.05). The antiproliferative effects of glycitin on A549 cells were mediated through stimulation of apoptosis and cell cycle arrest at G0/G1-phase. The compound also distorted normal cellular morphology by causing membrane damage and nuclear fragmentation. The proportion of cells in the G0/G1-phase increased after glycitin treatment, when compared to the other two phases, demonstrating cell cycle arrest (p < 0.05). Glycitin suppressed the migration and invasion of A549 cells. However, Western blotting results showed that glycitin down-regulated the expressions of PI3K/AKT signaling proteins in A549 cells (p < 0.05).
      Conclusion: Glycitin produced significant anticancer effect on A549 cells via enhanced apoptosis, induction of cell cycle arrest, and inhibition of PI3K/AKT signalling. Moreover, it suppressed the migration and invasion of A549 cells. Therefore, glycitin is a potential lead molecule for the development of a therapeutic agent for invasive lung cancer.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.6
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effect of glaucocalyxin B on the protein expressions of PTEN, Beclin1 and
           LC3 in a mouse model of transplanted cervical cancer, and its significance
           

    • Authors: Zheng Zhao, Zhengyang Han, Cong Huang, Feixiang Yang
      Pages: 951 - 956
      Abstract: Purpose: To determine the effect of glaucocalyxin B (GLB) on the protein expressions of PTEN, Beclin1 and LC3 in a mouse model of transplanted cervical cancer, and its significance.
      Methods: A mouse model of transplanted cervical cancer was established in female BALB/C mice. The model mice were divided into control group, low-dose GLB group and high-dose GLB group. Mice in low-dose and high-dose groups were given intraperitoneal injection of low-dose GLB and high-dose GLB, respectively. The volume and weight of transplanted tumor were measured and compared between the two groups. Serum levels of CEA and CA125 were assayed by enzyme-linked immunosorbent assay (ELISA). The expressions of phosphatase and tensin homolog (PTEN), autophagy-related factor microtubule-associated protein-1 (Beclin-1), microtubule-associated protein 1 light chain 3 (LC3), apoptosis-related protein p53, and Bax were determined using SABC immunohistochemical operation.
      Results: On days 5, 10 and 15, the volume and weight of transplanted tumor, and levels of CA125 and CEA in low- and high-dose GLB groups were significantly and dose-dependently lower than those in control group (p < 0.05). Results from immunohistochemistry showed that the protein expression levels of PTEN, Beclin-1, LC3, p53 and Bax were significantly and dose-dependently higher in low- and highdose GLB groups than in the control group (p < 0.05).
      Conclusion: Glaucocalyxin B significantly and dose-dependently induces apoptosis of cervical cancer cells and inhibits their growth by regulating the protein expressions of PTEN, Beclin1 and LC3. Thus, glaucocalyxin B is a potential adjunct therapy in the management of cervical cancer.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.7
      Issue No: Vol. 21, No. 5 (2022)
       
  • TRIM52 promotes proliferation, invasion, and migration of gastric cancer
           cells by regulating Wnt/β-catenin pathway

    • Authors: Beiyi Zheng, Jianhua Wang, Haozhen Wang, Wenling Wang, Yude Jin
      Pages: 957 - 963
      Abstract: Purpose: This study aimed to reveal the role and mechanism of tripartite motif-containing 52 (TRIM52) in gastric cancer (GC) progression.
      Methods: The Cancer Genome Atlas (TCGA) database was utilized to analyze TRIM52 expression in GC samples and para-carcinoma tissue samples, and the results were confirmed by quantitative realtime polymerase chain reaction. Cell counting kit-8 and colony formation assays were used to evaluate cell viability. Wound healing assay was utilized to analyze cell migration, while Transwell assay was utilized to evaluate cell invasion. TRIM52, proliferating cell nuclear antigen, matrix metalloproteinase-2, Wnt5a, β-catenin, and c-Myc protein levels were measured by western blot.
      Results: TRIM52 was expressed more in GC tissue samples and cells compared to normal tissues and cells (p < 0.001). Overexpression of TRIM52 promoted growth, migration, and invasion of HGC-27 cells, and silencing inhibited growth, migration, and invasion of HGC-27 cells (p < 0.001). In addition, TRIM52 overexpression increased Wnt5a, β-catenin, and c-Myc protein expression, and silencing decreased Wnt5a, β-catenin, and c-Myc protein expression (p < 0.001 or p < 0.01), indicating that TRIM52 activates Wnt/β-catenin signaling pathway.
      Conclusion: These findings reveal that TRIM52 facilitates GC cell proliferation, migration and invasion, but activates Wnt/β-catenin signaling.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.8
      Issue No: Vol. 21, No. 5 (2022)
       
  • Simvastatin suppresses cerebral aneurysm in rats through suppression of
           release of pro-inflammatory cytokines

    • Authors: Congcong Chen, Hongdan Wei, Jiawen Song, Xiaona Zhang
      Pages: 965 - 971
      Abstract: Purpose: To investigate the protective effect of simvastatin (SA) against onset of cerebral aneurysmmediated inflammatory cytokine release and subsequent inflammation and degradation of the extracellular matrix of smooth muscle cells.
      Methods: Cerebral aneurysm was induced in male Wistar rats using elastase injection, and aneurysm growth was monitored for one month following SA treatment. Inhibition of aneurysm growth was determined along with the expression levels of chemokines and pro-inflammatory cytokines, including TNF-α, IL-8, IL-1β, IL-17, IL-6, macrophage chemoattractant protein-1 (MCP-1), and matrix metalloproteinases 2 and 9, using enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR).
      Results: Aneurysm size decreased in rats treated with SA, relative to values obtained for control rats (p < 0.05). The corresponding expressions of inflammatory cytokines and chemokines were also reduced following pre-treatment with SA (p < 0.05). The results indicate a reduction in the aneurysm area in rats pre-treated with SA, when compared to the untreated animals (p < 0.05).
      Conclusion: SA treatment inhibits the progression of cerebral aneurysms via its protective effect against inflammation, indicating its potential for use in the prevention and treatment of cerebral
      aneurysms.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.9
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effect of taxifolin on acrylamide-induced oxidative and proinflammatory
           lung injury in rats: Biochemical and histopathological studies

    • Authors: Omer Faruk Demir, Bekir Elma, Bahadir Suleyman, Mustafa Ozkaraca, Renad Mammadov, Halis Suleyman, Taha Abdulkadir Coban, Fatih Ozcicek
      Pages: 973 - 979
      Abstract: Purpose: To examine the probable beneficial effects of taxifolin against acrylamide damage in lung tissue.
      Methods: 18 male albino Wistar rats were divided into healthy (HG), acrylamide (AG) and taxifolin + acrylamide (TAG) groups. Once a day for 30 days, acrylamide was orally administered to the AG group (50 mg/kg), while ACL (50 mg/kg) and TAX (20 mg/kg) were orally administered to TAG group. Protein concentration, malondialdehyde (MDA), and total glutathione (tGSH) levels as well as oxidant and antioxidant molecules concentrations of the rat lung tissues were measured. In addition, degree of mononuclear (MN) cell infiltration and bronchial-associated lymphoid tissue (BALT) hyperplasia was evaluated by the degree of hyperplasia (absent, mild, moderate, severe). The histopathological and
      biochemical data the groups were compared.
      Results: When compared in terms of MDA levels, it was found that the AG group had high MDA levels, and the TAG group had low MDA levels. (p < 0.001). TAG group was found to have a higher tGSH level than the AG group (p < 0.001). Compared to the AG group, lower TOS and higher TAS levels were obtained in the TAG group (p < 0.001). In addition, when TOS levels of TAG and HG groups were compared, the TOS levels between the two groups were statistically insignificant (p = 0.213). It has been observed that TAX administration prevents the increase in NF-ƘB level. When the NF-ƘB levels of the AG and TAG groups were compared with each other, there was a statistically significant difference (p = 0.001). In the AG group, severe MN cell hyperplasia and BALT hyperplasia were observed histopathologically. It was determined that these findings were alleviated in the TAG group. A histopathologically significant difference was found between AG and TAG groups (p < 0.05).
      Conclusion: Taxifolin has beneficial effects against lung injury caused by acrylamide, a healthdamaging environmental factor. Regular use of taxifolin can be recommended, especially in people who are known to have intense contact with acrylamide. There is a need for research studies on this subject.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.10
      Issue No: Vol. 21, No. 5 (2022)
       
  • Systematic elucidation of the traditional Chinese medicine prescription
           Danxiong particles via network pharmacology and molecular docking

    • Authors: Ning Li, Keixin Liu, Mai Yu, Shani Li, Mingjuan Liu, Wei Cai, Aiping Tian
      Pages: 981 - 987
      Abstract: Purpose: To investigate the pharmacological effect of the traditional Chinese medicine (TCM) prescription Danxiong particles (TDX105) and its mechanism of action.
      Methods: The active compound and targets of TDX105 were investigated via network pharmacology. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were enriched, and protein-protein interaction network (PPI) was constructed. A network of ‘components-targets-pathways’ was developed with Cytoscape 3.8.0 software, while the formation of molecular docking analysis was conducted using Autodock vina software.
      Results: There were 304 compounds and 482 targets identified in total. Genes with degree ≥ mean node values were selected as the crucial targets, and string database was to be combined to 64 targets identified with cytoscape so as to draw a protein interaction map. A total of 137 pathways were enriched from 64 targets involving mainly 10 pathways, for example, PI3K-Akt signaling pathway, pathways in cancer, human cytomegalovirus infection and focal adhesion. Then, compound-target and compoundtarget- pathways were constructed using cytoscape (3.8.0). Finally, the five most active compounds, viz, quercetin, myricetin, luteolin, ellagic acid and kaempferol, and the top ten targets AKT1, GAPDH, TP53, ALB, EGFR, MAPK3, JUN, MAPK1, SRC and ESR1 were selected for molecular docking. These targets and compounds had strong interactions through a combination of hydrogen bonds and hydrophobic forces.
      Conclusion: The mechanism of action of TDX105 has been successfully explained using the combination of network pharmacology and molecular docking. This may offer a solid foundation to the clinical use of TDX105, and further strengthen the prospects of its development for clinical use.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.11
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effect of estrogen application timing on adipose tissue revascularization
           and immune regulation in rats after autologous fat transplantation

    • Authors: Weigang Lin, Lili Zhu, Mirong Liao, Yunyan Zhang
      Pages: 989 - 994
      Abstract: Purpose: To study the effect of timing of estrogen application on adipose tissue revascularization and immune regulation in rats given autologous fat transplantation.
      Methods: Ninety (90) healthy rats were selected for use in this study. The rats were randomly divided into a study group (n = 45) and control group (n = 45). After ovariectomy, the study group was given estrogen replacement therapy before autologous fat transplantation, while the control group was given estrogen replacement therapy after autologous fat transplantation. The rats were observed for 6 weeks after transplantation. Micro-vessel density, wet weight of transplanted fat, VEGF expression level, levels of M1 and M2 in macrophages, and macrophage infiltration rate were determined 40 days postautologous fat transplantation.
      Results: Forty days after autologous fat transplantation, microvessel density, wet weight of transplanted fat, expression level of VEGF and levels of M1 and M2 in macrophages were significantly higher in study group rats than in controls (p < 0.05). There was 80 % macrophage infiltration in the study group rats, while the corresponding control value (61 %) was significantly lower (p < 0.05).
      Conclusion: Estrogen treatment before autologous fat transplantation in rats is helpful for the revascularization of adipose tissue, enhances vascular regeneration, promotes the survival of adipose tissue after transplantation, and activates immune cells. It also promotes the production of immune factors, and improves immunoregulation in adipose tissue. Thus, this therapeutic strategy may be useful in clinical practice, but further clinical trials are required.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.12
      Issue No: Vol. 21, No. 5 (2022)
       
  • The traditional Chinese medicine (TCM), Sheng-xue-xiaoban, inhibits the
           angiogenesis in ovarian cancer in vitro

    • Authors: Enqi Kong, Chao Zhang, Xia Li, Haiping Song, Li Sun, Jing Tian
      Pages: 995 - 1001
      Abstract: Purpose: The traditional Chinese medicine (TCM), Sheng-xue-xiao-van (SXXB) is reported to be effective in treatment of thrombocytopenic purpura and chemotherapy-induced thrombocytopenia in clinical practices. The purpose of this study was to explore the functions of the SXXB Capsule in ovarian cancer in vitro.
      Methods: The toxicity of the medicine was measured using CCK8 method in ovarian cancer cell lines A2780 and OC-3-VGH and also the human ovarian epithelial cell line IOSE80. The cells were treated using the DMSO-diluted SXXB solution with the concentration levels at0, 3.125 and 6.25 μg/ml. Western blot was applied to measure the VEGFA proteins in each group. Later, the cells treated with 0 and 25μg/ml SXXB solution for 48h were collected for supernatant. Then HUVECs were co-cultured with the supernatant. Migration and tube formation assays were performed thereafter.
      Results: SXXB solution showed higher toxicity in ovarian cancer cells than in IOSE80. The protein levels of VEGFA were reduced as the SXXB concentrations increased in ovarian cancer cells but not in IOSE80. Migration and formed tubes were inhibited in HUVECs co-cultured with the supernatant collected from SXXB-treated ovarian cancer cells.
      Conclusion: The SXXB Capsule might inhibit the angiogenesis in ovarian cancer in vitro.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.13
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effect of enalapril maleate-folic acid tablets on inflammatory response
           and myocardial endoplasmic reticulum stress-related factors in
           hypertensive rats

    • Authors: Yugang Zu, Xiaoqiong Zhang, Cuina Feng
      Pages: 1003 - 1008
      Abstract: Purpose: To determine the effect of enalapril maleate folate on inflammatory reaction and myocardial endoplasmic reticulum stress-related factors in hypertensive rats.
      Methods: Eighty (80) hypertensive rats with SBP > 140 mmHg were equally assigned to control and study groups. Rats in control group were given normal saline by gavage, while the observation group was given enalapril maleate powder (10 mg/kg/day). After 4 weeks of treatment, 2 mL of inferior vena cava blood was collected from each of the two rat groups. The level of homocysteine (Hcy) was determined with Hcy assay kit, while C-reactive protein (CRP) levels in patients were determined by latex immunoturbidimetry. Serum FBG was assessed using automatic biochemical analyzer. The expression levels of GRP78, CRP94, chop and caspase-12 in aortic smooth muscle cells were assayed immunohistochemically.
      Results: Central arterial pressure (MAP), aortic media thickness, lvwi, HWI FBG and CRP were significantly higher in the study rats, while Hcy level was lower, than in controls (p < 0.05). There were significantly lower levels of glucose regulatory protein 78 (GRP78), CRP94, CHOP and caspase-12 in study rats than in control rats (p < 0.05).
      Conclusion: Enalapril maleate-folate slows down inflammatory reaction by reducing the levels of Hcy, CRP and FBG. It inhibits the expressions of GRP78, CRP94, CHOP and caspase-12 in myocardium, reduces damage to myocardial cells, and alleviates or reverses left ventricular hypertrophy in rats with high blood pressure. This provides new insight into the research and development of other drugs.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.14
      Issue No: Vol. 21, No. 5 (2022)
       
  • Ethno-botanical survey of medicinal plants used traditionally in the
           treatment of mental disorders in Kano, Nigeria

    • Authors: Abdullahi R Abubakar, Ibrahim H Sani, Suleiman S Chiroma, Sani Malami, Abdullahi H Yaro
      Pages: 1009 - 1017
      Abstract: Purpose: To identify medicinal plants used by traditional medicine practitioners to treat mental disorders within Kano metropolis, Nigeria.
      Methods: A semi-structured questionnaire was administered. It was made up of demographic information (Section A), description of the medicinal plants (Section B), and the professional experience of the respondents (Section C). The data generated were recorded, processed and analyzed.
      Results: 255 responses were collected from 127 respondents. Among the participants, 101 (79 %) were male and 26 (21 %) were female. The age groups less than 31 years were 22 (17 %), 31 - 40 years were 29 (23 %), 41 - 50 years were 45 (36 %), and above 51 years were 31 (24 %). The sources of knowledge identified include ancestral (83 %), ancestral/training (9 %), training (6 %), and divination (2 %). Out of the total responses, fifty (50) different medicinal plants with various claims in the treatment of mental disorders were reported. The most commonly stated medicinal plants were Securidaca longepedunculata (8.6 %), Jatropha curcas (7.5 %), Solanum aethiopicum (7.1 %), Artemesia annua (6.7 %), Terminalia macroptera (6.3 %), Aristolochia albida (5.9 %), Nigella sativa (5.5 %), Andira inermis (5.5 %), Calotropis procera (5.1 %), and Burkea africana (4.7 %).
      Conclusion: This survey revealed fifty medicinal plants used traditionally in the treatment of mental disorders within Kano metropolis.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.15
      Issue No: Vol. 21, No. 5 (2022)
       
  • Spectrum-effect relationship between HPLC fingerprints and inhibitory
           activity in MUC5AC mucin of Pinelliae Rhizoma Praeparatum Cum Alumine

    • Authors: YuJie Liu, Ke Pei, LiYing He, MeiBian Hu
      Pages: 1019 - 1026
      Abstract: Purpose: To investigate the spectrum-effect relationship between HPLC fingerprints and the inhibitory effect on MUC5AC mucin of Pinelliae Rhizoma Praeparatum Cum Alumine (PRPCA).
      Methods: The fingerprints of 20 PRPCA batches were established using HPLC and their similarities or differences were analyzed using hierarchical cluster analysis (HCA) and principal component analysis (PCA). The inhibitory effects of MUC5AC mucin were evaluated in LPS-treated NCI-H292 cells. The spectrum-effect relationship between common chromatographic peaks and MUC5AC inhibition was established using a partial least squares-discriminant analysis (PLS-DA).
      Results: Fifteen common chromatographic peaks were identified by analyzing HPLC fingerprints, with uridine, tyrosine, uracil, and inosine found as possible markers to distinguish the PRPCA from different sources. Spectrum-effect relationship analysis showed that the chromatographic peaks 5, 6, 10 (vernine), 12 (5-hydroxymethylfurfural), 14 (tryptophan) and 15 (adenosine) were closely associated with the inhibitory effect on MUC5AC mucin.
      Conclusion: The spectrum-effect relationship between HPLC fingerprints and the inhibitory effect on MUC5AC mucin of PRPCA was successfully established in the present study. Our findings further reveal the material basis of PRPCA and provide an effective method for its quality control.
      PubDate: 2022-06-17
      DOI: 10.4314/tjpr.v21i5.16
      Issue No: Vol. 21, No. 5 (2022)
       
  • Electrospray ionization-mass spectrometry of different extracts of the
           organs of Rumex cyprius and their antihepatotoxic effect

    • Authors: Basma G Eid, Nadia M Sokkar
      Pages: 1027 - 1035
      Abstract: Purpose: Phytochemical and biological investigations of the valuable plant, Rumex cyprius, family Polygonaceae, wildly grown in Saudi Arabia.
      Methods: Chloroform, ethyl acetate and methanol extracts were prepared from the different organs of R. cyprius. The extracts were analyzed by electrospray ionization source coupled to a mass spectrometer (ESI-MS) and tandem mass spectrometer (ESI-MS/MS) at different collision energies. The plant organs (leaf, fruit and stem) were standardized on the bases of quercetin by HPLC, and determined for their hepatoprotection in tetrachloride-induced acute liver toxicity using a mouse model.
      Results: Twenty-five phenolic compounds distributed between the leaf, fruit and stem of R. cyprius were identified. They were related to classes of anthraquinones, phenolic acids, flavonoid aglycones, glycosides and polyphenols. Twenty-two compounds in total were found and identified, and for the hepatoprotective effects, the leaf exhibited the best activity.
      Conclusion: R. cyprius is a source of potentially active phytoconstituents and a good natural
      hepatoprotective drug. This study is being documented for the first time.
      PubDate: 2022-06-18
      DOI: 10.4314/tjpr.v21i5.17
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effect of montelukast/budesonide formoterol powder inhalation in chronic
           obstructive pulmonary disease

    • Authors: Zuoping Chen, Xiaojun Qian
      Pages: 1037 - 1043
      Abstract: Purpose: To investigate the clinical efficacy of montelukast/budesonide formoterol powder inhalation in treating chronic obstructive pulmonary disease (COPD) and its impact on serum high-sensitivity Creactive protein (hs-CRP), cancer antigen 125 (CA-125), and interleukin (IL)-6 levels.
      Methods: In total, 86 COPD patients treated in the clinic of Department of Respiratory Medicine in
      Yichun People’s Hospital between December 2019 and December 2020 were recruited and randomly assigned to group A and group B alternately at the point of admission. Group B received conventional treatment, while group A was treated with conventional treatment plus montelukast/ budesonide formoterol powder inhalation.
      Results: Patients receiving montelukast /budesonide formoterol powder inhalation showed lower scores for cough, sputum, and shortness of breath, compared conventional treatment (p < 0.001). Patients in group A showed lower serum levels of hs-CRP, CA-125, and IL-6 after treatment than those in group B (p < 0.05). Pulmonary function and arterial blood gas indices were significantly different between the two groups after treatment (p < 0.05). Montelukast /budesonide formoterol powder inhalation resulted in higher Generic Quality Of Life Inventory-74 (GQOLI-74) scores and 6-min walking distance (6MWD) scores in patients than conventional treatment (p < 0.001). Also, Group A had a lower incidence of adverse reactions than group B (p < 0.05).
      Conclusion: Montelukast/budesonide formoterol powder inhalation has a better therapeutic effect versus conventional treatment, and improves patients' lung function and exercise tolerance. Further clinical trials are, however, required prior to general use in clinical practice.
      PubDate: 2022-06-18
      DOI: 10.4314/tjpr.v21i5.18
      Issue No: Vol. 21, No. 5 (2022)
       
  • Impact of intravenous administration of anisodamine on coronary
           microvascular dysfunction in patients with obstructive epicardial coronary
           artery disease after percutaneous coronary intervention

    • Authors: Liang Chen, Bei Lei, Ying Lou, Lixiu Chen, Jinqi Jiang
      Pages: 1045 - 1053
      Abstract: Purpose: To analyze intravenous administration of anisodamine’s impact on coronary microvasculardysfunction (CMD) in obstructive epicardial coronary artery disease (CAD) patients who had undergone percutaneous coronary intervention (PCI).
      Methods: Enrollment of 210 patients in Shanghai Chest Hospital, Shanghai Jiaotong University with CMD was done in a randomized-controlled study. They were divided randomly into groups, viz, anisodamine (A) group and nitrate (N) group. A 14-day course of treatment was carried out in each group. 99mTc-MIBI myocardial perfusion imaging (MPI), treadmill exercise test (TET) and two dimensional echocardiography (TDE) were performed, and the symptoms of angina pectoris were recorded before and after treatment according to the classification, frequency, and duration of angina, as defined by Canadian Cardiovascular Society (CCS).
      Results: After treatment, summed stress score (SSS) and summed rest score (SRS) of MPI in group A significantly decreased after treatment (p < 0.001, respectively) and were remarkably lower than those in group N (p < 0.001, respectively). The CCS class in group A improved after treatment (p < 0.001) and was also better than in group N (p < 0.001). The frequency and duration of angina attack in group A significantly reduced after treatment (p < 0.001, respectively) and were notably lower than in group N (p < 0.001, respectively). Left ventricular ejection fraction in group A after treatment was higher than that before treatment (p = 0.046) and than that in group N (p = 0.048). Furthermore, the side effects of anisodamine were slight and tolerable.
      Conclusion: Intravenous administration of anisodamine is a potentially suitable optional treatment for CMD in patients with obstructive epicardial CAD who have undergone PCI.
      PubDate: 2022-06-18
      DOI: 10.4314/tjpr.v21i5.19
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effect and safety of combined Gegen Qinlian decoction/metformin in the
           treatment of diabetes mellitus in patients, and its influence on serum C
           peptide and glycosylated hemoglobin

    • Authors: Jie Chen, Yi Xu, Yan Zhao, Geling Liu, Jia Cui, Yan Li, Weijuan Li
      Pages: 1055 - 1060
      Abstract: Purpose: To investigate the clinical efficacy and safety of combined Gegen Qinlian decoction /metformin in the treatment of diabetes mellitus (DM), and its influence on serum C peptide and glycosylated hemoglobin (HbAlc).
      Methods: One hundred and eighty-six DM patients who received treatment in Tangshan Gongren Hospital, Tangshan City, China from July 2018 to November 2019 were randomly assigned to group X (n = 93) and group Y (n = 93). Group Y was given metformin, while X received a combination of Gegen Qinlian decoction and metformin. Total effectiveness, incidence of adverse reactions, blood glucose, TCM syndrome scores, as well as serum C peptide and HbAlc were determined and compared between the two groups.
      Results: Compared with group Y, group X had significantly higher treatment effectiveness (p < 0.05), lower incidence of adverse reactions (p < 0.05), significantly lower levels of blood glucose and TCM syndrome score after treatment (p < 0.001), but significantly higher serum C-peptide levels (p < 0.001) and lower levels of HbAlc.
      Conclusion: the combination of Gegen Qinlian decoction and metformin produces a good anti-diabetic efficacy, with a lower incidence of adverse reactions in patients. Therefore, the combined therapy has potentials for application in clinical practice, but further clinical trials are required.
      PubDate: 2022-06-18
      DOI: 10.4314/tjpr.v21i5.20
      Issue No: Vol. 21, No. 5 (2022)
       
  • Efficacy of roxithromycin with gamma globulin in children with mycoplasma
           pneumonia and its effect on immunity

    • Authors: Yihui ; Dong, Xuejiao Qi, Xiaojie Lin, Maomin Yu, Huijuan Zhang, Haixiang Sun
      Pages: 1061 - 1066
      Abstract: Purpose: To determine the efficacy of roxithromycin plus gamma globulin in the treatment of children with mycoplasma pneumonia (MPP) and its effect on immune function.
      Methods: From January 2019 to January 2021, 100 children with MPP assessed for eligibility in Qingdao Women and Children's Hospital, Shandong Province, China, were recruited and randomized (1:1) to receive either gamma globulin (control group) or roxithromycin plus gamma globulin (study group). Levels of tumor necrosis factor (TNF)-α, immunoglobulin (Ig)A, IgM, and IgG were evaluated. Clinical indices, including fever reduction, cough disappearance, duration of hospital stay, etc were also assessed.
      Results: The study group had a significantly higher clinical efficacy (88 %) than the control group (68 %) (p < 0.05). After treatment, patients in the study group showed lower levels of tumor necrosis factor (TNF)-α than those in the control group (p < 0.05). The eligible patients given roxithromycin plus gamma globulin showed significantly higher levels of immunoglobulin (Ig)A, IgM, and IgG versus those given gamma globulin alone (p < 0.05). Patients in the study group had a shorter time lapse before fever reduction, cough disappearance, lung sign disappearance, and duration of hospital stay than those in the control group (p < 0.05).
      Conclusion: Roxithromycin plus gamma globulin demonstrate significant benefits in the treatment of children with MPP by mitigating inflammatory response, enhancing immune function, and also significantly alleviating clinical symptoms. Thus, the combination treatment shows good potentials for use in clinical practice.
      PubDate: 2022-06-18
      DOI: 10.4314/tjpr.v21i5.21
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effectiveness of hydropathic compress of dandelion in ameliorating
           complications of arteriovenous fistula

    • Authors: Limei Li, Lufeng Bian, Hong Chen, Xinjian Li, Ruixia Hu
      Pages: 1067 - 1072
      Abstract: Purpose: To investigate the effect of dandelion hydropathic compress on the complications of autologous arteriovenous fistula (AVF).
      Methods: From January to June 2019, a total of 162 patients treated with arteriovenous fistula for hemodialysis in the blood purification department of Affiliated Hospital of Jining Medical University were enrolled. They were randomly assigned at a ratio of 1:1 to receive either conventional infrared irradiation (control group) or conventional irradiation plus dandelion hydropathic compress (study group). The clinical endpoint was the amelioration of the complications of arteriovenous fistula after 6 months of treatment.
      Results: Dandelion hydropathic compress combined with conventional infrared irradiation was associated with a significantly higher clinical efficacy (96.30 %) than conventional infrared irradiation alone (77.78 %). The application of dandelion hydropathic compress plus infrared irradiation resulted in significantly reduced pain, a better quality of life, and a lower incidence of complications (p < 0.05).
      Conclusion: Dandelion hydropathic compress plus routine nursing and infrared irradiation lower the incidence of complications, improve blood flow, relieve pain, and enhance the quality of life of patients. Further clinical trials are needed to confirm the usefulness of this therapeutic strategy.
      PubDate: 2022-06-18
      DOI: 10.4314/tjpr.v21i5.22
      Issue No: Vol. 21, No. 5 (2022)
       
  • Concurrent administration of amiodarone and atenolol in the treatment of
           coronary artery disease complicated with arrhythmia, and its effect on
           serum levels of CD40L, TNF-α and IL-6

    • Authors: Dejin Li, Chengyue Tang, Liqiong Xu, Xin Jin, Jianli Wu, Jiuju Ran, Anfang Chen
      Pages: 1073 - 1078
      Abstract: Purpose: To investigate the efficacy of the combination of amiodarone and atenolol in the treatment of patients with coronary artery disease (CAD) complicated with arrhythmia, and its effect on serum levels of CD-40L, TNF-α and IL-6.
      Methods: One hundred and twenty CAD patients with arrhythmia on admission in The First People's
      Hospital of Shuangliu District Chengdu, China were assigned to groups A and B, each having 60 patients. Amiodarone was administered to all the patients, while atenolol was additionally given to patients in group A. Levels of heart function indicators, inflammatory factors, blood pressure, heart rate, adverse reaction rate (ARR) and overall efficacy were evaluated for the two groups.
      Results: There were significantly improved levels of heart function indicators, and lower levels of CD40L, TNF-α and IL-6 in group A, when compared with group B (p < 0.001). Moreover, treatment effectiveness was higher in group A than in group B (p < 0.05). However, there was no significant difference (p > 0.05) in ARR between groups A and B.
      Conclusion: The combined use of amiodarone and atenolol improves heart function indicators in patients with CAD and arrhythmia, reduces the levels of inflammatory factors, normalizes blood pressure and heart rate, and lowers ARR. However, further clinical trials on this combined therapy are required prior to its use in clinical practice.
      PubDate: 2022-06-18
      DOI: 10.4314/tjpr.v21i5.23
      Issue No: Vol. 21, No. 5 (2022)
       
  • Efficacy and safety of post-auricular injection of methylprednisolone
           sodium succinate and lidocaine in the treatment of acute tinnitus, and its
           effect on sleep quality

    • Authors: Bijun Liang, Xiaohua Feng, Rui Deng, Youli Liu, Ying He, Xiwu Zhang
      Pages: 1079 - 1085
      Abstract: Purpose: To study the efficacy and safety of post-auricular injection of methylprednisolone sodium succinate plus lidocaine in the treatment of acute tinnitus, and its effect on sleep quality.
      Methods: Eighty acute tinnitus patients admitted to Nanfang Hospital, Southern Medical University, Guangzhou, China from January 2020 to June 2021, served as subjects for this retrospective analysis. The patients were equally assigned to a reference group given postauricular injection of lidocaine, and a research group treated with post-auricular injection of methylprednisolone sodium succinate in combination with lidocaine. Treatment efficacy values in the two groups of patients were determined and compared.
      Results: Total treatment effectiveness values in patients in the research group after one course of treatment, and at three months post-treatment, were significantly higher than the corresponding values in the reference group (p < 0.05). After treatment, the two groups had markedly improved Tinnitus Handicap Inventory (THI) scores, although patients in the research group had lower scores than those in reference group (p < 0.05). There were significant decreases in post-treatment pure tone threshold and Pittsburgh sleep quality index (PSQI) in the two groups of patients, with lower values in the research group than in the reference group (p < 0.05). There were no obvious adverse drug reactions during treatment and during 3-month follow-up period.
      Conclusion: Post-auricular injection of methylprednisolone sodium succinate and lidocaine effectively improved the clinical efficacy and the sleep quality of acute tinnitus patients. It is a simple and highly safe operation which merits clinical application.
      PubDate: 2022-06-24
      DOI: 10.4314/tjpr.v21i5.24
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effect of non-invasive ventilator in combination with tiotropium bromide
           on pulmonary function and sleep quality of patients with chronic
           obstructive pulmonary disease complicated with obstructive sleep
           apnea-hypopnea syndrome

    • Authors: Dongli Liu, Xiaolong He, Jianquan Gao, Qiangqiang Luan, Yanling Du
      Pages: 1087 - 1093
      Abstract: Purpose: To study the influence of non-invasive ventilator and tiotropium bromide on pulmonary function and sleep quality of patients with chronic obstructive pulmonary disease (COPD) combined with obstructive sleep apnea-hypopnea syndrome (OSAHS).
      Methods: One hundred and twenty patients with COPD-OSAHS were selected and randomly assigned to control group (CG) and treatment group (TG), with 60 subjects in each group. Non-invasive ventilator therapy was used in both groups, based on conventional therapy, while tiotropium bromide was added in TG. Treatment effectiveness in the two groups was evaluated and compared.
      Results: Total effectiveness was significantly higher in TG than in CG. Post-therapy arterial oxygen saturation (SaO2) and oxygen partial pressure (PaO2) were increased, while partial pressure of carbon dioxide (PaCO2) and lactic acid (Lac) were decreased in both groups (p < 0.05). Post-treatment values of indices of lung function, viz, forced expiratory volume (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio were higher than the corresponding pre-treatment levels, and also values were significantly higher in TG than in CG (p < 0.05). Average sleep time, apnea and hypopnea index (AHI) and mechanical ventilation time of TG were less than those of CG. There were lower levels of Creactive protein (CRP), procalcitonin (PCT) and interleukin-17 (IL-17) in TG than in CG. During the treatment, no obvious adverse reaction was seen in both groups.
      Conclusion: Non-invasive ventilator, in combination with tiotropium bromide, is more effective in the treatment of COPD-OSAHS than the use of non-invasive ventilator alone. However, further clinical trials are required before its adoption in clinical practice.
      PubDate: 2022-06-19
      DOI: 10.4314/tjpr.v21i5.25
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effectiveness of simvastatin/aspirin combination in the treatment of
           coronary heart disease in the elderly, and its effect on cardiac function
           and levels of inflammatory factors

    • Authors: Jinya Lu, Hongli Cai, Yefei Li, Jiayi Chen
      Pages: 1095 - 1100
      Abstract: Purpose: To investigate the efficacy of simvastatin plus aspirin in the treatment of coronary heart disease in the elderly, and its effect on cardiac function and inflammatory factor levels.
      Methods: Eighty-seven identified elderly patients with coronary heart disease who were admitted to Nantong First People's Hospital, Nantong, China between January 2020 and June 2021 were recruited and assigned at a ratio of 1:1 to receive either conventional treatment (group A) or simvastatin plus aspirin (group B). The clinical endpoint was treatment efficacy.
      Results: No significant differences were found between the two groups in respect of their baseline data (p > 0.05). Simvastatin plus aspirin was associated with a significantly higher treatment efficacy versus conventional treatment (p < 0.05). The patients, after joint therapy, had more cases of grade I cardiac function and fewer cases of grade III cardiac function, compared with conventional treatment group (p < 0.05). The application of simvastatin plus aspirin resulted in lower levels of triglycerides (TGs), total cholesterol (TC), fasting plasma glucose (FPG), low-density lipoprotein cholesterol (LDL-C), and highdensity lipoprotein cholesterol (HDL-C) than the conventional treatment (p < 0.05). Simvastatin plus aspirin was also associated with lower levels of interleukin (IL)-6 and hypersensitive-c-reactive-protein (hs-CRP) when compared with conventional treatment (p < 0.05). Furthermore, simvastatin plus aspirin produced a similar incidence of adverse events with conventional treatment (p > 0.05).
      Conclusion: Simvastatin/aspirin combination therapy is effective in the treatment of coronary heart disease in the elderly. It efficiently lowers glucose levels, lipid metabolism, and inflammatory factors, but enhances the cardiac function of patients.
      PubDate: 2022-06-19
      DOI: 10.4314/tjpr.v21i5.26
      Issue No: Vol. 21, No. 5 (2022)
       
  • Fulvestrant, an estrogen receptor inhibitor, relieves postoperative
           hemorrhoid edema via up-regulation of miR- 424-5p

    • Authors: Fanyu Meng, Xinghua Chen, Huajiang Liu, Lei Zhang, Ting Yu, Minning Xie
      Pages: 1101 - 1107
      Abstract: Purpose: To investigate estrogen receptor (ER) expression in postoperative hemorrhoid edema tissues, and the likely mechanism involved in fulvestrant-mediated reduction of postoperative hemorrhoid edema.
      Methods: One hundred and eighty-five patients admitted to Jinshan Hospital of Fudan University, Shanghai who accepted hemorrhoidectomy were enrolled in this study. Primary cells were extracted from the anal margin tissues of patients for the determination of changes in ERα and vascular endothelial growth factor (VEGF). In vitro cellular experiments were performed in primary vascular endothelial cells to verify whether ER promoted postoperative perianal edema via the miR-424-5p estrogen receptor α gene (ESR1) axis. The cells were exposed to Fulvestrant, estradiol, and miR-424-5p mimic. Changes in expressions of ERα and VEGF were determined.
      Results: Fourteen patients (7.57 %), comprising 2 males (2.60 %) and 12 females (11.1 %), developed
      postoperative anal margin edema. There was a significant difference in the incidence of postoperative anal edema between males and females (p < 0.05). Both immunohistochemistry and immunoblotting revealed markedly higher ERα levels in postoperative anal edema tissues than in preoperative tissues (p < 0.05). Moreover, ERα level was regulated by estradiol, and miR-424-5p targeted the estrogen receptor α gene (ESR1).
      Conclusion: Estradiol inhibits miR-424-5p through ERα in perianal tissues after hemorrhoid surgery. It increases VEGF and promotes perianal edema. However, fulvestrant inhibits ERα, thereby reducing VEGF expression and mitigating postoperative hemorrhoid edema, and therefore, has potential application for the management of postoperative hemorrhoid edema.
      PubDate: 2022-06-19
      DOI: 10.4314/tjpr.v21i5.27
      Issue No: Vol. 21, No. 5 (2022)
       
  • Effect of modified Wenyang Buxin decoction and routine therapy on cardiac
           function and serum levels of H-FABP, cTnI and Ang-2 in chronic heart
           failure patients

    • Authors: Chengsi Qian, Yan Sun
      Pages: 1109 - 1115
      Abstract: Purpose: To investigate the effect of modified Wenyang Buxin decoction and routine therapy on cardiac function and serum levels of heart-type fatty acid binding protein (H-FABP), cardiac troponin-1 (cTnI) and angiopoietin-2 (Ang-2) in chronic heart failure (CHF) patients.
      Methods: A total of 120 CHF patients admitted to Zhejiang Province Rongjun Hospital (from January2019 - January 2020) were selected for this study. They were randomly but equally distributed into groups A and B. All patients were given routine therapy such as diuretic treatment and detumescence, while those in group A received 150 mL of modified Wenyang Buxin decoction daily, in addition to routine therapy. At 2 months after therapy, cardiac function indices, serum H-FABP, cTnI and Ang-2 levels, hemorheology indices, traditional Chinese medicine (TCM) syndrome scores, and Chinese questionnaire of quality of life in cardiovascular patients (CQQC) scores of the two groups were evaluated.
      Results: After therapy, cardiac function indices, serum H-FABP, cTnI and Ang-2 levels, hemorheology indices as well as TCM syndrome score and CQQC score were significantly improved in group A, when compared with corresponding values in group B (p < 0.05).
      Conclusion: Modified Wenyang Buxin decoction and routine therapy improves serum biomarker levels, cardiac function and quality of life, and relieves clinical symptoms of CHF in patients. Therefore, this treatment approach may be useful in the management of CHF patients.
      PubDate: 2022-06-19
      DOI: 10.4314/tjpr.v21i5.28
      Issue No: Vol. 21, No. 5 (2022)
       
  • Efficacy of imatinib mesylate in combination with radiotherapy in acute
           leukemia, and the effect on immune function

    • Authors: Mei Zhou, Liming Zhang
      Pages: 1117 - 1123
      Abstract: Purpose: To evaluate the clinical efficacy of imatinib mesylate plus radiotherapy for the treatment of acute leukemia and its effect on immune function.
      Methods: A retrospective study was conducted on 88 patients with acute leukemia admitted to Zhuji Affiliated Hospital of Shaoxing University between July 2017 and July 2021. They were assigned (randomly, 1:1)  to a control group (radiotherapy) or a study group (imatinib mesylate plus radiotherapy) according to different treatment regimens. Outcome measures assessed included the clinical efficacy of the treatments in the patients and their immune functions.
      Results: The two groups did not show any significant differences with regard to general patient profiles. After treatment, both groups presented reduced white blood cell (WBC) and platelet count (PLT) and elevated red blood cells count (RBC). The level of hemoglobin (Hb) level showed a slight decline in the control group but a significant increase in the study group (p < 0.05). The study group showed better improvement in the levels of WBC, PLT, RBC, and Hb than the control group (p < 0.05). The absolute values of peripheral blood mature neutrophils decreased in both groups after treatment, down to the lowest level at week 2, but rebounded, with higher absolute values in the study group at weeks 2, 3, and 4 of treatment (p < 0.05). Imatinib mesylate plus radiotherapy was associated with higher efficacy, compared with radiotherapy alone (p < 0.05).
      Conclusion: Radiotherapy plus imatinib mesylate effectively enhances the immune functions of acute leukemia patients, mitigates inflammatory responses, alleviates clinical symptoms, and boosts clinical efficacy. Further clinical trials are, however, required prior to general application in clinical practice.
      PubDate: 2022-06-19
      DOI: 10.4314/tjpr.v21i5.29
      Issue No: Vol. 21, No. 5 (2022)
       
  • Traditional Chinese medicine combined with conventional treatment for the
           patients after percutaneous coronary intervention: A systematic review and
           meta-analysis

    • Authors: Lin Renyong, Xiao Ting, Chou Qiaoling, Liu Hongtao, Zhang Le
      Pages: 1125 - 1134
      Abstract: Purpose: To evaluate the efficacy, quality of care and safety of Traditional Chinese Medicine (TCM) after Percutaneous Coronary Intervention (PCI). using systematic review and meta-analysis of randomized controlled trials.
      Methods: Relevant studies published between January 1st 2010 and August 20th, 2021, on traditional Chinese medicine (TCM) and conventional treatment (CT) after PCI were sourced from different databases including CNKI, CBM, Web of Science, PubMed, Embase and Cochrane library. The TCM was composed of preparations of chinese eaglewood, peppermint, radix notoginseng, scabrous elephant foot herb, Tongxinluo, Danhong, Naoxintong capsule, Huxin Formula and liquorice root while the CT included aspirin (100 mg/day), clopidogrel (75 mg/day), and statins. PRISMA guidelines were used. Primary outcome was to evaluate the efficacy, quality of care and safety of TCM versus conventional treatment post percutaneous coronary intervention (PCI).
      Results: 110 randomized controlled trials (RCTs) were retrieved and analyzed. The results from metaanalysis showed an enhanced left ventricular ejection fraction (LVEF) % among patients that received TCM compared to those on CT [mean difference ± sd (MD)=5.17, 95% CI (3.29-7.06), Z = 5.38, (P < 0.001)]. Further, hypersensitive C-reactive protein (HS-CRP) level in TCM group was found to be relatively lower than that of the CT group (CG) [MD=-1.44, 95% CI (-2.87-0.00), Z=1.96, (P=0.05)]. In terms of safety, TCM group relative risk score in fixed-effect model was lower than that of the CG [RR=0.66, 95% CI (0.40, 1.10), Z=1.66,].
      Conclusion: It can be inferred from the results that TCM has more advantages in terms of clinical efficacy, quality of care and safety compared to conventional therapy. However, the lack of substantial research in deploying TCM for the treatment of CHD demands further exploration and strong evidence prior to clinical application of TCM.
      PubDate: 2022-06-19
      DOI: 10.4314/tjpr.v21i5.30
      Issue No: Vol. 21, No. 5 (2022)
       
 
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