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Dhaka University Journal of Pharmaceutical Sciences
Journal Prestige (SJR): 0.183
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1816-1820 - ISSN (Online) 1816-1839
Published by Bangladesh Journals Online Homepage  [87 journals]
  • Identification of Natural Compounds with Anti-SARS-CoV-2 Activity using
           Machine Learning, Molecular Docking and Molecular Dynamics Simulation

    • Authors: - Arifuzzaman, Mohadese Mohammadi, Fatema Hashem Rupa, Mohammad Firoz Khan, Ridwan Bin Rashid, Mohammad A Rashid
      Pages: 1 - 13
      Abstract: The coronavirus pandemic of 2019 (COVID-19) has adversely affected public health and the socioeconomic situation worldwide. Although there is no therapeutic drug to treat COVID, several treatment options are being considered to alleviate symptoms. Hence, researches on prophylactic treatment for COVID are being encouraged. Searching natural products is a rational strategy since it has served as a valuable source of lead compounds in drug discovery. In this study, three machine learning approaches, including Support Vector Machine (SVM), Random Forest (RF) and Gradient Boosting Machine (GBM), have been used to develop the classification model. The molecular docking was performed on AutoDock vina. Further, molecular dynamics (MD) simulation of the potential inhibitors was conducted using the AmberTools package. The accuracy for SVM, RF and GBM was found to be 60.45 %, 63.43 % and 64.93 %, respectively. Further, the model has demonstrated specificity range of 41.67 % to 50.00 % and sensitivity range of 74.32 % to 79.73 %. Application of the model on the NuBBE database, a repository of natural compounds, led us to identify 322 unique natural compounds, likely possessing anti-SARSCoV- 2activity. Further, molecular docking study has yielded three flavonoids and one lignoid compounds with comparable binding affinities to the standard compound. In addition, MD showed that these compounds form stable complexes with different magnitude of binding energy. The in silico investigations suggest that these four compounds likely demonstrate their anti-SARS-CoV-2activity by inhibiting the main protease enzyme. Our developed and validated in silico high-throughput investigations may assist in identifying and developing antiviral drug-like compounds from natural sources. Dhaka Univ. J. Pharm. Sci. 21(1): 1-13, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60391
      Issue No: Vol. 21, No. 1 (2022)
  • Evaluation of Antioxidant, Antibacterial and Analgesic Activities of
           Syzygium cumini used in Bangladesh

    • Authors: Margia Sultana, Jamiuddin Ahmed, Md Abdul Barek, Shaidul Kabir Sohag, Md Safayet Hossain, Umme Habiba
      Pages: 15 - 24
      Abstract: Syzygium cumini (L.) skeels (Family: Myrtaceae) is a renowned medicinal plant traditionally used in various diseases and available in Bangladesh. This investigation was aimed to explore whether this plant has any potential antioxidant, antibacterial, and analgesic effects of methanolic extracts of S. cumini (leaves and bark). Quantitative determination of methanolic extracts of leaves and bark found the total phenolic contents as 199.11 mg GAE/g DW and 204.03 mg GAE/g DW, respectively. The leaves extract possessed mild antibacterial activity (leaves: 7.00 mm at 1 mg/disc, 9.15 mm at 5 mg/disc) against two different bacteria at different concentration whereas the bark extract showed no effect. A significant writhing (leaves: 23.17 ± 1.80, p≤0.001; bark: 24.33 ± 1.15, p≤0.001) and licking effects (leaves: 8.17 ± 1.49 sec, p≤0.05; bark: 9.08 ± 1.96 sec, p≤0.05) were found at 400 mg/kg of leaves and bark extracts of this plant which is very close to standard drugs mentioned in the tables. Results of this study demonstrated that methanolic extracts of S. cumini leaf and bark possessed significant antioxidant, analgesic, and mild antibacterial like activities which tend to suggest medicinal aspects. Dhaka Univ. J. Pharm. Sci. 21(1): 15-24, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60392
      Issue No: Vol. 21, No. 1 (2022)
  • Design and Development of Clarithromycin Floating Pellets Using Sodium
           Alginate and HPMC

    • Authors: Md Abdul Motaleb Bhuiya, Kishor Mazumder, Irin Dewan, Md Elias Al Mamun
      Pages: 25 - 31
      Abstract: The purpose of our study was to achieve the gastro-retentive delivery of Clarithromycin by producing floating pellets to get a better therapeutic effect against gastrointestinal ulcers mostly caused by Hedyotis pylori. Thereby Clarithromycin floating pellets were prepared by utilizing the blending of polymers such as Sodium (Na) Alginate and Hydroxy Propyl Methyl Cellulose (HPMCK4M & HPMC K100LV). The HPMC-alginate blend containing Clarithromycin produced a hydrogel bead that was able to show buoyancy in the simulated gastric fluid. The pellets showed more than 8 hours of buoyancy depending on their polymeric ratio. In addition to the buoyancy test, several other tests like floating time (upto 12 hrs with increasing Na-Alginate), contraction ratio, particle size analysis, were performed that showed the development of acceptable floating pellets. Furthermore, SEM was performed on the prepared Clarithromycin pellet to assess their morphological characteristics. Clarithromycin floating pellets with 1.5% Na-alginate & HPMC K4M: HPMC K100LV (1:2) give the better formulation and produce pharmaceutically acceptable parameters. Dhaka Univ. J. Pharm. Sci. 21(1): 25-31, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60393
      Issue No: Vol. 21, No. 1 (2022)
  • Qualitative Phytochemical Screening, Fatty Acid Composition Analysis and
           Biological Studies of Trianthema portulacastrum L. Leaves

    • Authors: Vaskar Chowdhury, Nusrat Tabassum Shristy, Md Hasanur Rahman, Tofail Ahmad Chowdhury
      Pages: 33 - 43
      Abstract: Trianthema portulacastrum L. commonly known as ‘horse purslane’ and locally called ‘shvetapunarnava’ is an annual broadleaf plant of tropical areas throughout the world. In this study, determination of moisture and ash content of the plant leaves, as well as qualitative phytochemical test, cytotoxicity assay, antimicrobial activity, fatty acid composition, total phenolic content, total flavonoid content, total antioxidant capacity, and DPPH radical scavenging activity were carried out. Methanol extract of T. portulacastrum leaves was partitioned using Kupchan's method with different solvents of increasing polarity (n-hexane, dichloromethane, chloroform, ethyl acetate). The moisture and ash contents of the leaves were (81.74±0.49)% and (31.05±1.36)%, respectively. Initial phytochemical screening of T. portulacastrum showed the presence of alkaloids, tannins, flavonoids, and tri-terpenoids. In fatty acid composition analysis, both bound fatty acids and free fatty acids were isolated from n-hexane extract that showed the presence of the highest percentage of palmitoleic acid (67.095% and 48.843%, respectively) and stearic acid (12.14% and 20.437%, respectively). Dichloromethane and methanol extracts were found to be cytotoxic on HeLa cells in cytotoxicity assay against Vero, HeLa, and BHK-21 cell lines. The highest phenolic content was observed in ethyl acetate extract (68.55±0.038 mg/g) and the highest flavonoid content was found in chloroform extract (477.01±0.104 mg/g). The DCM fraction revealed the highest total antioxidant capacity (284.99±0.113 mg/g), and the IC50 value for ethyl acetate extract was the lowest (110.35±0.160 μg/ml) of all the extracts. Dhaka Univ. J. Pharm. Sci. 21(1): 33-43, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60394
      Issue No: Vol. 21, No. 1 (2022)
  • Predictors of Adherence and Asthma Control in Two Federal Teaching
           Hospitals in Nigeria

    • Authors: Chinwendu Amorha Amorha, Mathew J Okonta, Chinwe V Ukwe
      Pages: 45 - 51
      Abstract: Asthma is a common chronic disease in developing countries. The main objective of the study was to provide insights into adherence and asthma control predictors in two federal teaching hospitals in Nigeria, using validated instruments. For the data analysis, the level of statistical significance was set as p < 0.05. Seventy-eight patients with asthma provided consent for study participation. Every time domestic fuel was utilized at home, asthma control decreased by 1.246 units, p = 0.029. Every time an asthma patient utilized one of the hospitals which did not have a separate Asthma Clinic, adherence decreased by 1.483 units, p < 0.001. The study reveals the need for patients with asthma to minimize the use of domestic fuel. Renewable energy sources could be considered. A separate Asthma Clinic can provide ample time for asthma reviews. Dhaka Univ. J. Pharm. Sci. 21(1): 45-51, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60395
      Issue No: Vol. 21, No. 1 (2022)
  • Isolation, Characterization and Identification of Selected Microorganisms
           from Wildlife Geophagic Soil: A Probe of Pros and Cons

    • Authors: Rilwan O Adewale, Oluwatosin T Onasanya, Oladele A Oguntade, Babajide R Odebiyi, Oluseun A Akinsorotan, Kola S Olorunisola, Shakiru O Sule, Olusesi A Oso
      Pages: 53 - 58
      Abstract: The search for novel antibiotics for treating human-wildlife infections has not stopped. This study isolated and characterized bacteria and fungi from wildlife geophagic termite mounds (TMs) using standard microbiological procedure. Four composite samples of TMs evident to be eaten by wildlife were randomly collected (TM1, TM2, TM3 and TM4) in addition with a composite forest soil (FS5) that showed no sign of consumption. With the use of appropriate media, all samples were subjected to microbiological analysis covering morphological, biochemical (for bacteria), colonial and cellular morphology (for fungi). Bacteria and fungi cells isolated and characterized from respective soil samples include; Streptomyces lydicus/Aspegillus niger (TM1), Paenibacillus polymyxa/Penicillium digitatum (TM2), Pseudomonas fluorescens/Fusarium spp. (TM3), Bacillus subtilis/Aspergillus flavus (TM4) and Acinetobacter radioresistens/Geotricihum candidum (FS5), all of which have both beneficial and harmful characteristics. Wildlife may be affected by pathogenic organisms when consuming TMs for medicinal reasons. Dhaka Univ. J. Pharm. Sci. 21(1): 53-58, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60396
      Issue No: Vol. 21, No. 1 (2022)
  • Qualitative Assessment of a Customized Anti-hepatic Herbal Formulation in

    • Authors: Md Hafizur Rahman, Begum Rokeya, Mohammed Mosihuzzaman, Md Shahinul Haque Khan
      Pages: 59 - 67
      Abstract: Qualitative assessment of herbal formulations is used in pre-health care of many diseases. The potency, composition and safety of herbal formulation are serious concerns in Bangladesh. Therefore, the aim of the present study was to evaluate the qualitative assessment of a customized anti-hepatic herbal formulation in Bangladesh. Isolation of compounds, toxic metals analysis, phytochemical screening, microbial test and determination of SGPT and SGOT level of hepatic model rats were focused in this study. The phytochemical screening revealed the presence of phenol, saponins and tannins. In chemical study, four known compounds were isolated from the formulation (Sodium benzoate, methyl-4-hydroxybenzoate, 4-hyroxybenzaldehyde and 4-hydroxy- 3-methoxybenzaldehyde). The results of microbial purity and toxic metals analysis were in favorable limit although the levels of SGOT and SGPT were raised non-significantly. So, based on the study it has been concluded that quality assessment is urgently required for this type of customized herbal formulations. Dhaka Univ. J. Pharm. Sci. 21(1): 59-67, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60397
      Issue No: Vol. 21, No. 1 (2022)
  • Phyto-pharmacological Investigations of Leaves of Cissus trifoliata (L.)

    • Authors: Mehedi Islam, Md Al Amin Sikder, Mohammad A Rashid, Md Khalid Hossain
      Pages: 69 - 75
      Abstract: Repeated chromatographic separation and purification of dichloromethane soluble partitionate of methanol extract of leaves of Cissus trifoliata (L.) yielded a total of four compounds, namely β-sitosterol (1), β- sitostenone (2), epifriedelanol (3) and friedelin (4). The structures of the isolated chemical compounds were established by high field nuclear magnetic resonance (NMR) analyses, comparison with previously published data and co-TLC with authentic samples, whenever possible. Compounds 1-4 appeared to be the first time they were identified in this plant species. The methanol extract of C. trifoliata was assessed for central and peripheral analgesic activities by tail immersion and acetic acid-induced writhing reflex methods, respectively. The crude extract demonstrated significant central and peripheral analgesic efficacy at 200- and 400-mg/kg b.w. in mice model. The general toxicity of the extractives was assessed through a brine shrimp lethality bioassay, where the ethyl acetate (LC50=0.88 μg ml–1) and dichloromethane (LC50=0.93 μg ml–1) soluble fractions demonstrated considerable activity. The crude extract at 400 mg/kg (b.w.) also displayed significant antidiarrheal activity, whereas its dichloromethane soluble fractions exhibited moderate thrombolytic activity. Dhaka Univ. J. Pharm. Sci. 21(1): 69-75, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60398
      Issue No: Vol. 21, No. 1 (2022)
  • Development and Optimization of RP-UHPLC Method for Mesalamine Through QbD

    • Authors: Diponkor Kumar Shill, Uttom Kumar, ASM Monjur Al Hossain, Md Rezowanur Rahman, Abu Shara Shamsur Rouf
      Pages: 77 - 84
      Abstract: The current study aimed at developing and optimizing a prompt, simple and efficient RP-UHPLC method based on Quality by Design (QbD) for analyzing mesalamine. Experimental design for developing the method was performed capitalizing a 32 full factorial design in Design Expert® software (Version 12, Stat-Ease Inc., USA) where the percentage of methanol in the mobile phase and flow rate of the mobile phase were considered as independent factors and studied at three levels. Retention time, tailing factor and theoretical plate count were recorded as responses to the experiment. Mesalamine was analyzed using a reversed-phase C18 column (5μm, 150 ×4.6 mm) supported by a photodiode array plus (PDA+) detector with detection at 214 nm. The optimized method involved the use of a mobile phase of pH=7.4 phosphate buffer: methanol (63.5: 36.5, v/v) and a flow rate of 1.1 ml/min. Responses recorded during experimentation exhibited an error of -0.24%, 0.376% and -0.659% from predicted values of retention time, tailing factor and theoretical plate count, respectively. Experimental models adopted for the development of the method were found statistically significant (p-value <0.05). According to ICH Q2 (R1) guidelines, the method was also found to be robust, highly sensitive, specific, accurate, precise and linear. Dhaka Univ. J. Pharm. Sci. 21(1): 77-84, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60399
      Issue No: Vol. 21, No. 1 (2022)
  • Antioxidant, Analgesic, Antimicrobial and Molecular Docking Studies of the
           Leaves of Oroxylum indicum (L.) Kurz.

    • Authors: Arifa Sultana, Sabiha Enam Spriha, SM Abdur Rahman
      Pages: 85 - 94
      Abstract: This study presents the findings of in vivo, in vitro and in silico investigations of the Oroxylum indicum (L.) Kurz leaf extracts. Various fractions namely chloroform (CF), ethyl acetate (EAF), n-hexane (HF) and aqueous fractions (AF) obtained from the crude extract were subjected to biological investigations. In DPPH based free radical scavenging assay, CF and MF fractions showed potent antioxidant activity with IC50 9.70 g/ml and 10.46 g/ml as compared to IC50 8.56g/ml for the standard ascorbic acid. The CF and HF fractions of O. indicum (L.) Kurz leaves exhibited mild antimicrobial activity. In analgesic activity screening by acetic acid induced writhing method, EAF showed significant writhing inhibition of 68% and 72%, at doses 150 mg/kg and 300 mg/kg, respectively. In tail immersion method, EAF also showed potent analgesic activity with reaction time of 1.816 ± 0.047 and 2.15 ± 0.041 min, after 30 minutes following oral doses of 150 mg/kg and 300 mg/kg, respectively. Molecular docking of previously isolated compounds from O. indicum (L.) Kurz leaf extracts were docked against cyclooxygenase-1 (COX-1) and cyclooxygenase -2 (COX-2) and revealed that the flavonoids baicalein and chrysin may be responsible for the analgesic activity. Lipinski’s rule of five was also calculated for the compounds to assess drug likeliness. Dhaka Univ. J. Pharm. Sci. 21(1): 85-94, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60400
      Issue No: Vol. 21, No. 1 (2022)
  • Review on Some Bangladeshi Medicinal Plants with Anticancer Properties

    • Authors: Sania Ashrafi, Mohammad Mehedi Masud
      Pages: 95 - 104
      Abstract: According to WHO, cancer is one of the leading causes of death worldwide, accounting for an estimated 9.6 million deaths in 2018. More significant improvements have been made in the management and treatment of cancer, still there remains scope for the betterment of treatment procedures. Mostsynthetic anticancer drugs are known to develop resistance, show cytotoxicity against normal cells due to their non-selective nature, and cause tremendous side effects. Medicinal plants are significantly feasible sources of organic compounds, for their better availability, cheaper price, fewer side effects, and sometimes better therapeutic efficacy, which may benefit the world commercially or act as an important starting point for identifying lead compounds to develop modified derivatives. This article describes the ethnobotanical properties of 15 available medicinal plants of Bangladesh having anti-cancer properties. Dhaka Univ. J. Pharm. Sci. 21(1): 95-104, 2022 (June)
      PubDate: 2022-06-26
      DOI: 10.3329/dujps.v21i1.60401
      Issue No: Vol. 21, No. 1 (2022)
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