Authors:
Elion Itou RDG; Etou Ossibi AW, Morabandza CJ, Boumba Y, Abena AA Pages: 1 - 7 Abstract: Covid-Organics is an improved traditional medicine made from a plant called Artemisia annua Linn. It is developed by the Malagasy Institute for Applied Research with the aim is to treat coronavirus disease or Covid-19. The present study aims to justify the use of Covid-Organics by evaluating the anti-inflammatory, analgesic and antipyretic activities. Acute inflammation was induced by using the carrageenan and formaldehyde models. The results obtained show that Covid-Organics at the doses used significantly reduces (p PubDate: 2023-01-12 DOI: 10.12691/ajps-11-1-1 Issue No:Vol. 11, No. 1 (2023)
Authors:
Akassa Herman; Peneme Bonaventure Max Lazare, Etou Ossibi Wilfrid Arnauld, Morabandza Cyr Jonas, Kanga Marie Roselyne, Goma Dinouvanza Lèges Aphrodite, Abena Ange Antoine Pages: 8 - 14 Abstract: The main purpose of the present study was to evaluate the androgenic and antioxydant effects of ethanolic extract of Strychnos camptoneura trunk bark in Wistar rats. For this purpose, 20 rats were randomly arranged in 4 lots of 5 animals each and received respectively for lots 1 and 2 distilled water and testosterone enanthate and lots 3 and 4 treated with ethanolic extract of Strychnos camptoneura (100 and 250 mg /kg). It appears from this study that the administration of ethanolic extract of Strychnos camptoneura orally at the doses studied causes significant increases in body weight gain (p < 0.05; p < 0.01 and p < 0.001) in rats in contrast to the animals of the negative control lot that received distilled water. Administration of Strychnos camptoneura extract at the doses studied did not induce any significant change (P> 0.05) in the relative weights of testes, vas deferens, seminal vesicles, and penis compared to negative control rats. Furthermore administration of ethanolic extract of Strychnos camptoneura at the doses studied induced a significant increase (p < 0.01 and p < 0.001) in serum and testicular testosterone levels in rats compared to those treated with distilled water. Chemical analyses performed in this study revealed the presence of total polyphenols (TPP) and flavonoids in the ethanolic extract of Strychnos camptoneura. These results suggest that the ethanolic extract of Strychnos camptoneura would have androgenic and antioxidant properties and would justify its use in traditional Congolese medicine for the treatment of male infertility. PubDate: 2023-03-14 DOI: 10.12691/ajps-11-1-2 Issue No:Vol. 11, No. 1 (2023)
Authors:
Oussou N’Guessan Jean-Baptiste; Kouakou Kouakou Léandre, Ehile Ehilé Hervé, Yoboue Kouamé Landry, Yapo Angoué Paul, Ehile Ehouan Etienne Pages: 15 - 20 Abstract: Macaranga barteri and Terminalia superba are two plants from the Ivorian flora used in traditional medicine to treat gastric disorders. This study aims to evaluate the cyprotective effect of a herbal formulation based on these herbs (AEMbTs) against induced ulcers in rats. The cytoprotective effect of AEMbTs was carried out on HCl/Ethanol and ibuprofen rats’ models. For each model, nine groups of six rats each were formed. The rats were orally pretreated with distilled water (Groups I and II), those of groups III and IV received Cimetidine (12 mg/kg bw) and Maalox (50 mg/kg bw) respectively in HCl/Ethanol model while Misoprostol (0,012 mg/kg bw) and Ranitidine (50 mg/kg bw) were respectively used as standard drugs in ibuprofen model. The rats in groups V to IX received AEMbTs at the respective doses of 31.25; 62.50; 125; 250 and 500 mg/kg bw. In the HCl/ethanol model, one hour after administration of the various treatments, all groups except group I received HCl/Ethanol orally at 1 ml/150 g bw. All the animals were sacrificed one hour later. As for the ibuprofen model, thirty (30) minutes after the treatments, all the animals except those of group 1 received orally a first dose of ibuprofen (500 mg/kg bw). Fifteen hours after the first dose, a second dose of ibuprofen was administered. Six (6) hours later, all the animals were sacrificed, the mucus was collected and weighed, the ulcerations were measured, the ulceration index and the inhibition percentage of the ulcerations were calculated. The results showed that the doses of AEMbTs induced significant decrease (p PubDate: 2023-05-23 DOI: 10.12691/ajps-11-1-3 Issue No:Vol. 11, No. 1 (2023)
Authors:
Jyoti Singh; Amit Jaiswal, Anil Kumar Pal Pages: 21 - 27 Abstract: Tin has a variety of advantageous biological effects. The majority of tin complexes are effective against a wide range of different disorders, including convulsion, tumor, cancer, malaria, tuberculosis, and diabetes. The majority of the tin complex exhibits drug-like antibacterial and antifungal properties. Tin complexes have greater activity than free ligands like macrocyclic and Schiff bases. A new series of tin (II) and tin (IV) complexes were formed as a result of n - heterocyclic Schiff base ligand. Three tin (IV) complexes, H-ClQ=5, 7-dichloro-8-hydroxylquinoline, H-BrQ=5, 7-dibromo-8-hydroxylquinoline, and H-ClIQ=5-chloro-7-iodo-8-hydroxylquinoline, were created. There in vitro information about the condition against the cell lines BEL7404, SKOV-3, NCI-H460, and HL-770 Having IC50 values that range from 20 nm to 5.11 mM, the compound exhibits strong anti-proliferative action against the investigated cell lines. Most complexes showed significantly increased cytotoxicity as compared to 5, 7-dihalo-8-quinolinol (except 2 against SKOV-3 and NCI-H460). Additionally, they showed some selective cytotoxicity that favoured the tested tumor cells over the healthy HL-7702 cells from the human liver. Complexes 1-3 bind DNA more firmly compared to their quinolinol ligands. Macrocyclic molecules, which include porphyrin rings connected to metal ions in cytochromes, heamoglobin, and chlorophyll, may have significant effects on the biochemistry of biological systems. The biological applications of complexes of transition metals with ligands have been the subject of extensive research. The most likely binding mode for the aggregates with their quinolinol ligands is intercalation. The significance of tin applications in biological processes is explained in this review paper. PubDate: 2023-06-09 DOI: 10.12691/ajps-11-1-4 Issue No:Vol. 11, No. 1 (2023)
Open Access journal
