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Bangladesh Pharmaceutical JournalNumber of Followers: 0
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- Formulation of Self Micro-Emulsifying Dry Powder of Zingiber officinale
(Rhizome) and Its Effect on Hepatoprotective Activity in Mice Model-
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Authors: Md Shariful Islam, Md Abdur Rahman, Imtiaz Ahmed , Mohammad Salim Hossain
Pages: 125 - 133
Abstract: Liver complication is a major concern in the world. Finding out a new way to combat various liver diseases is very much required. Ginger has been reported to have hepato-protective activity. Here we aimed to formulate an oil-based (self-micro emulsifying) powder to improve the hepatoprotective activity of dry powder of Zingiber officinale (Ginger). Four different formulations of self-microemulsifying dry powder were prepared by mixing with different excipients. The formulated powder was characterized for the angle of repose, Hausner ratio and compressibility index. The hepato-protective activity of the formulated powder was evaluated in vivo. All of the parameters tested for powder characterization showed a good response in terms of flow property and compressibility. Formulated powder exhibited a significant decrease (p<0.05) in hepatic enzymes like aspartate transaminase (AST) and alanine transaminase (ALT) in carbon tetrachloride (CCl4) induced hepatotoxic mice compared to fresh ginger powder group which indicates the enhanced hepatoprotective activity of prepared self-micro emulsifying power in hepatotoxicity. Bangladesh Pharmaceutical Journal 26(2): 125-133, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67801
Issue No: Vol. 26, No. 2 (2023)
- Screening of Aptamers that Bind to the Multivalent Aminoglycoside Amikacin
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Authors: AHM Khurshid Alam, Yoshiko Miura, Aziz Abdur Rahman, Md Golam Sadik, Mamunur Rashid, Toshifumi Tsukahara
Pages: 134 - 143
Abstract: Increased awareness of the multiple roles of RNA molecules has led to the realization that, in addition to their structural and functional roles, RNAs can be drug targets for small molecular therapy. Amikacin, a member of the aminoglycoside group of antibiotics, binds to specific sites in bacterial 16S ribosomal RNAs (rRNAs) and interferes with protein synthesis leading to cell death. Here, we used the systemic evolution of ligands by exponential enrichment (SELEX) method to isolate high affinity RNA fragments (aptamers) that bind to amikacin. After five rounds of SELEX selection, in which a linear N25 DNA template was used for the first selection cycle, the resulting RNA was cloned and sequenced. Among the 38 clones generated, five groups of sequences (groups A through E) containing nine conserved motifs were identified. The sequences of groups A and B were almost identical, indicating that the selected RNA was enriched. Subsequently, the Basic Local Alignment Search Tool program was used to search for the conserved motifs in bacterial 16S rRNA sequences. Strikingly, no sequence homology was observed, suggesting that the conserved sequences (motifs) identified in this studymay be novel target sites for amikacin. Bangladesh Pharmaceutical Journal 26(2): 134-143, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67802
Issue No: Vol. 26, No. 2 (2023)
- Analgesic Activity of Methanolic Extract of Litsea deccanensis Gamble Bark
in Mice Model-
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Authors: Israt Jahan Bulbul, Mohammad Rashedul Haque, Mohammad A Rashid
Pages: 144 - 149
Abstract: Litsea deccanensis Gamble. (Family: Lauraceae) is used traditionally for sprained or swollen joints such as ankles or knee. Still, there is no report for its analgesic activity, therefore the present study was aimed to evaluate analgesic activity of the crude methanolic extract of L. deccanensis (MELD) bark in various mice models. Acetic acid-induced writhing, Eddy’s hot plate and formalin induced paw licking tests were performed to evaluate the pain reducing/relieving effects. In acetic acid-induced writhing model, MELD showed significant reduction of squirming (p < 0.001, p < 0.01 and p < 0.05) in a dose dependent manner as compared to control. In the heat induced pain model (Eddy’s hot plate method), MELD showed a slight increment of the latency time for the initiation of the reaction in the experimental animals, that revealed a moderate analgesic activity of MELD when compared to control group, but the results were insignificant. Whereas, in the formalin induced pain model, the reaction time was decreased significantly (p < 0.05) with the increment of doses for the studied plant extract (MELD) as well as standard in the late phase (20-30 min) of the study. So, the present study concluded a significant reduction of acetic acid-induced squirming or writhing, and formalin induced biting or licking in mice, provided us the evidence of having pain reducing potential. Bangladesh Pharmaceutical Journal 26(2): 144-149, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67803
Issue No: Vol. 26, No. 2 (2023)
- In vitro Antibacterial and Cytotoxic Activities of Various Fractions of
Lippia alba (Mill.)-
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Authors: Md Omar Ali, Naznin Ara Khatune, AHM Khurshid Alam, Md Aziz Abdur Rahman
Pages: 150 - 156
Abstract: Lippia alba (Mill.) (Family: Verbenaceae) is widely known due to both ethnobotanical uses and chemical diversity. The present work was designated to determine the antimicrobial and cytotoxic activities of the aqueous ethanolic extract and various fractions of this plant. The whole plant was made into coarse powder and was extracted with 5% aqueous ethanol. The concentrated ethanolic extract (abbreviated as LAE) was successively partitioned with n-hexane (LAH), chloroform (LAC), ethyl acetate (LAA), and the remaining part was designated as water (LAQ). The antimicrobial and cytotoxic activities of extract and all these fractions were evaluated in vitro using disc diffusion technique and brine shrimp (Artemia salina) lethality assay, respectively. In antimicrobial assay, five Gram-positive and five Gram-negative bacteria and standard antibiotic ciprofloxacin (10 μg/disc) were used. All the samples were tested at four concentrations (200, 400, 600 and 800 μg/disc). Our study showed that the extractive and different fractions of L. alba had antibacterial activity against all the tested bacteria except Pseudomonas aeruginosa. Among the extractives, LAE and LAH had significant antibacterial activity when compared to standard ciprofloxacin. The zone of inhibition of LAE and LAH were found to be 14.4, 24.4, 13.4, 15.2, 18.5, 24.1, 16.1, 23.5, 23.2 and 14.5, 20.1, 12.5, 17.1, 17.5, 20.1, 12.5, 19.4, and 18.16 mm against Bacillus cereus, Staphylococcus aureus, Streptococcus-β- haemolyticus, Bacillus subtilis, Sarcina lutea, Escherichia coli, Klebsiella pneumonia, Salmonella typhi and Shigella dysenteriae, respectively, at 800 μg/disc. The median lethal concentration (LC50) in brine shrimp lethality bioassay was determined by extrapolation from graph and the values were found to be 41.9, 23.9, 21.3, 88.7, 6.7 and 7.5 μg/ml for LAQ, LAH, LAC, LAA, LAE and standard vincristine sulfate, respectively. In the study, different mortality rate was observed at different concentration and all the samples showed positive response, indicating the presence of cytotoxic components in L. alba. Phytochemical screening revealed that L. alba contains saponins, tannins, glycosides, steroids, alkaloids, terpenoids and flavonoids. The results of the study indicate that L. alba might be a good source of potent antibiotic and anticancer drugs. Bangladesh Pharmaceutical Journal 26(2): 150-156, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67804
Issue No: Vol. 26, No. 2 (2023)
- A Cross-sectional Study on the Prescription Pattern of Undenatured
Collagen-II in Bangladeshi Patients-
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Authors: Md Mahbubul Alam, Md Sakib Rayhan, Arnob Ghosh, ASM Monjur Al Hossain
Pages: 157 - 161
Abstract: Numerous clinical and experimental studies have shown that individuals with a variety of orthopedic diseases can get benefit from the undenatured form of type II collagen (UC-II). It has proved its efficacy and long lasting effectiveness for several orthopedic patients throughout different countries in the world. But in Bangladesh it is not frequently prescribed yet. Therefore, we made the decision to conduct a survey-based study to determine the number of patients prescribed with UC-II under which pathological conditions and to what extent they have got relief from their joint associated ailments. To conduct the study, we visited the orthopedic department of various hospitals in Bangladesh and with consent from patients we collected pictures of prescriptions as well as got overview regarding their complications. We gathered photographs of 252 prescriptions from orthopedic department patients, among which only 31 patients were prescribed with UC-II. According to this study, 40.47 , 32.54 , 15.47 , 9.12 and 2.38 % of patients were over the age group of 60 , 50 , 40 , 30 and 20 - years respectively. We found that a range of individuals with various orthopedic problems such as osteoarthritis, spondylosis, right tibial plateau, paresthesia in right upper limb and various bone fractures were advised with UC-II. However, we discovered only in 12.30% of prescriptions that the doctors prescribed UC-II, indicating this is a less common practice in Bangladesh in spite of its huge potential to recover joint pain associated complications. Bangladesh Pharmaceutical Journal 26(2): 157-161, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67805
Issue No: Vol. 26, No. 2 (2023)
- Evaluation of Antioxidant, Cytotoxic, Thrombolytic and Membrane
Stabilizing Activities of Canna indica L. Leaves (Family: Cannaceae)-
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Authors: Sheikh Alma, Umme Tamima Tamme, Asif Uj Jaman, Md Nasir Uddin, Saimon Shahriar, Mohammad A Rashid
Pages: 162 - 166
Abstract: Canna indica L., a perennial plant known as Indian shot and African arrowroot, is a member of the family Cannaceae. Historically, this plant was used to treat menstrual cramps, diarrhea and dysentery. The purpose of this investigation was to assess the antioxidant, cytotoxic, thrombolytic and membrane stabilizing activities of the methanol extract of C. indica leaf and its organic soluble fractions. The DPPH free radical scavenging method and the total phenolic content determination were utilized to evaluate the antioxidant capacity, whereas the brine shrimp lethality bioassay was implemented to study the cytotoxic potential. The ability of the extractives to prevent the hemolysis of red blood cells (RBC) in response to the application of heat and hypotonic solutions was used to estimate of their membrane stabilizing potential. In all of these experiments, the methanolic leaf extract (ME) displayed moderate activity, while the petroleum ether soluble fraction (PSF) and the dichloromethane soluble fraction (DSF) demonstrated the most promising antioxidant and cytotoxic activities among the extractives. However, the strongest thrombolytic and membrane stabilizing activities were observed by the chloroform soluble fraction (CSF). Additional research may be necessary to determine which phytoconstituents are most likely to be responsible for the aforementioned qualities. Bangladesh Pharmaceutical Journal 26(2): 162-166, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67806
Issue No: Vol. 26, No. 2 (2023)
- Bioactive Secondary Metabolites to Combat Diabetic Complications:
Evidenced from in Silico Study-
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Authors: Hasin Hasnat, Suriya Akter Shompa, Fahmida Tasnim Richi, Md Mirazul Islam, Mehedi Hasan Suman, Nazim Uddin Ahmed, Sania Ashrafi, Anika Zaman, Tanoy Saha, Md Ashraful Islam, Safaet Alam
Pages: 167 - 184
Abstract: Diabetes mellitus (DM) is a condition characterized by excessive blood sugar levels, which have recently reached the level of a pandemic. There are various side effects of each drug to treat this condition. Molecular docking is a modern concept for computer-aided drug designing. Using this technique several potential antidiabetic phytocompounds are evaluated against three target receptors including GLUT-3, PPARγ and α-amylase related to DM. These compounds' ADMET and drug-likeliness characteristics have also been assessed to determine potential drug candidacy. Most of the compounds exhibited magnificent binding affinity against these targets, especially compounds 30 and 27 have shown great affinity against GLUT-3 with values of -11.2 and -10.2 Kcal/mol respectively. Where compound 37 has the highest binding affinity (-9.1 Kcal/mol) against PPARγ. Also, with values of -11.6 and -10.8 Kcal/mol respectively compounds 38 and 12 notably bind with α-amylase. Moreover, all of these compounds have magnificent results on ADMET and drug-likeliness studies, in particular, compound 29 has shown high affinity against all of these receptors, explored 0.55% bioavailability score, no toxicity and high absorptivity. Although these compounds have undergone a preliminary drug discovery study, more research must be done to determine their precise mechanism of action against DM. Bangladesh Pharmaceutical Journal 26(2): 167-184, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67807
Issue No: Vol. 26, No. 2 (2023)
- Exploring Pharmacological Potentials of p-Coumaric Acid: A Prospective
Phytochemical for Drug Discovery-
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Authors: Anika Zaman, Hasin Hasnat, Zakaria Al Noman, Md Mirazul Islam, Abdullah Al Nakib, Swakshar Mukherjee, Kabbo Saha, Nazim Uddin Ahmed, Sania Ashrafi, Tanoy Saha, Md Ashraful Islam, Safaet Alam
Pages: 185 - 194
Abstract: p-coumaric acid, commonly referred to as 4-hydroxycinnamic acid, is a phenolic acid, which has been subjected to much research in recognition of its beneficial properties against several diseases and its widespread distribution in the plant kingdom. This compound can be found in the free-state or coupled with other molecules in nature. It has demonstrated prospective pharmacological effects including antiproliferative, nephroprotective, neuroprotective, antioxidant and antimicrobial effects in addition to other biological properties through numerous in vivo, in vitro and clinical studies. This review reported a short summary on p-coumaric acid to provide fundamental information in its biosynthesis, plant sources, and pharmacological effects which may help in future research and development of novel therapeutics. Bangladesh Pharmaceutical Journal 26(2): 185-194, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67808
Issue No: Vol. 26, No. 2 (2023)
- Prevalence and Determinants of Caesarean Section in a Private Health
Facility: A Cross-sectional Study-
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Authors: Tanzina Binta Enam, Silvia Afrin, Hasan Mahmud Reza, Manik Chandra Shill
Pages: 195 - 203
Abstract: Emergency obstetric care (EmOC) has dramatically lowered the maternal death rate in Bangladesh since the early 1990s. Rising caesarean section rates over the past ten years have had an impact on the nation's economy in addition to other signs of better mother care. According to demographic and health surveys, caesarean section rates increased from 3.5% in 2004 to 23% in 2014. Women who become pregnant after 35 years, live in cities, have a higher level of education and frequently use antenatal services have a greater average annual rate of prevalence in caesarean sections. The objective was to assess the indications and the trends of caesarean sections done over a two-month period. The study of prevalence and determinants of caesarean section was conducted in a renowned private hospital in Dhaka. Among 197 women who were admitted to the department of obstetrics and gynecology, the number of total deliveries was 175 (89% of total admission). The indications varied a little in cases of lower abdominal pain and preeclampsia. Antepartum hemorrhage (APH) and breech have a small proportion (about 5% both). The proportion of repeated caesarean sections was 47%. Recently the indication of a maternal choice is also coming up (11%). The data were compared and analyzed to determine if the indications were significant enough for cesarean delivery. Although a caesarean section is currently a relatively safe obstetrical procedure, it is advised that the indications should be carefully evaluated in order to lower caesarean section rates. Bangladesh Pharmaceutical Journal 26(2): 195-203, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67809
Issue No: Vol. 26, No. 2 (2023)
- Mutational and Phylogenetic Analyses of SARS-Cov-2: Bangladesh Perspective
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Authors: BM Fahim Faisal, Md Selim Reza
Pages: 204 - 211
Abstract: Severe acute respiratory syndrome or SARS-Cov-2 is a global pandemic causing over 6.5 million deaths worldwide. As a part of the global village, Bangladesh is also heavily affected with more than 29,000 deaths in those two years of pandemic. Though the severity and mortality rate are not so high compared to the other countries, Bangladesh also faced many difficulties combating the mutated and newer types of the Covid-19. The evolution and phylogenetic study of the virus is one of those key areas to focus in order to understand the nature of virus, its mutation pattern and gene prediction. This study investigates the evolutionary links among the older and newly emerged SARS‐Cov‐2 variants. In this study, the entire genome sequences of SARS‐Cov‐2 variants were obtained, aligned using muscle alignment, pairwise comparison was computed, differences, gaps and mutations were noted. The phylogenetics of different types of covid-19 variants were determined using a variety of evolutionary substitution models. The ultrametric and metric clustering methods, such as UPGMA and neighbor‐joining (NJ), using nucleotide substitution models allowed the inclusion of nucleotide transitions and transversions as Kimura 80 models. The findings revealed that Omicron variant forms a new monophyletic clade that is distant from other SARS‐Cov‐2 variants but surprisingly in proximity to the alpha variant, which was actually dominant in the early stage of pandemic. This finding also indicates that the omicron variant might have been there for a while, hiding the virulence and later becomes the variant of concern in the latest wave of the pandemic. This may pave the way for new researchers to find proper insight of different variants of Bangladesh in treatment plan and vaccine designing. Bangladesh Pharmaceutical Journal 26(2): 204-211, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67810
Issue No: Vol. 26, No. 2 (2023)
- Formulation and Estimation of Rapidly Dissolving Sublingual Thin Film of
Vildagliptin-
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Authors: Sayeda Mushfika Akter, Sreebash Chandra Bhowmik, Marzia Alam, Saimon Shahriar, Tanoy Saha, Md Saiful Islam Pathan
Pages: 212 - 218
Abstract: The purpose of the present research was to develop a fast and rapidly dissolving polymeric sublingual thin film of vildagliptin due to its simplicity of use as an alternative to oral disintegrating tablets and better compliance for diabetic patients. Nine different formulations (F1-F9) of vildagliptin sublingual films were produced using diverse concentrations of polymer A and plasticizer B by solvent casting method. Several physicochemical properties, including morphological properties, weight variation test, film thickness, folding endurance, surface pH, percentage of moisture loss, in-vitro disintegration test, in-vitro dissolution test, trinocular microscopic imaging of film, differential scanning calorimetry (DSC), FTIR study and content uniformity were evaluated. The ratios of polymer A-plasticizer B were as follows (5:1), (7:1), (7.67:1), (8:1), (8.5:1), (8.67:1, (9.67:1), (10:1), (11:1) which made the film smooth, mechanically strong and easy to peel out. Among all the different formulations, the F1 formulation showed the most significant result concerning in-vitro dissolution (98.95%) in 5 minutes, minimum disintegration time (38 sec.), less film thickness (116.67 ± .58 μm) and better folding endurance (403 times). Bangladesh Pharmaceutical Journal 26(2): 212-218, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67811
Issue No: Vol. 26, No. 2 (2023)
- Review on Bombax ceiba Linn.: A Potential Remedy for Chronic Diseases
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Authors: Raisa Sharmili Habib, Md Rafat Tahsin, Fahima Aktar, Jakir Ahmed Chowdhury, Abu Asad Chowdhury, Shaila Kabir, Md Shah Amran
Pages: 219 - 229
Abstract: Chronic diseases are serious health concern all over the world and these are adding immense sufferings to millions of people. These remain persistent in one’s life and have long lasting effects on human life. Plant-based therapies can act as potential remedies to manage or cure these diseases with fewer, if not, no adverse effects and at a reasonable cost than the commercially available modern drugs. Furthermore, the constituents can be genetically modified to make them therapeutically effective against chronic diseases like diabetes, chronic inflammatory skin disease, chronic kidney disease, hypertension, cancer, ischemic heart disease and so on. Bombax ceiba Linn. is a tall, deciduous, multipurpose, miraculous tree that has numerous phytochemical constituents such as quercetin, carotenoids, β-sitosterol, α-tocopherol etc. along with shamimin, a novel compound that can help to treat chronic disorders. It has a long history for its medicinal uses. It is even highly regarded among aboriginal peoples for the remedy of various human and animal illnesses. Bangladesh Pharmaceutical Journal 26(2): 219-229, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67812
Issue No: Vol. 26, No. 2 (2023)
- New Drug Approvals Vol. 26(2)
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Authors: Md Abdur Rashid
Pages: 230 - 231
Abstract: Abstract not available Bangladesh Pharmaceutical Journal 26(2): 230-231, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67979
Issue No: Vol. 26, No. 2 (2023)
- New Indications & Dosage Forms for Existing Drugs Vol. 26(2)
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Authors: Md Abdur Rashid
Pages: 232 - 236
Abstract: Abstract not available Bangladesh Pharmaceutical Journal 26(2): 232-236, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67980
Issue No: Vol. 26, No. 2 (2023)
- Current Health News Vol. 26(2)
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Authors: Md Abdur Rahim
Pages: 237 - 238
Abstract: Abstract not available Bangladesh Pharmaceutical Journal 26(2): 237-238, 2023 (July)
PubDate: 2023-08-08
DOI: 10.3329/bpj.v26i2.67981
Issue No: Vol. 26, No. 2 (2023)
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