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Authors:Tushar Dilip Sonawane, S.P. Pawar Pages: 1 - 20 Abstract: The main aim of present investigation was to develop and study mucoadhesive buccal tablets of sumatriptan succinate using different bioadhesive polymer. Nine formulations were prepared by using direct compression method with varying concentration of polymer as HPMC (Metolose SR 90SH-15000), xanthan gum (XTGM) and sodium carboxy methyl cellulose (sodium CMC). Fourier transform infrared spectroscopy was used to identify drug excipient interaction. Micromeritic properties of lubricated blend, physical properties and chemical evaluation of compressed tablet was performed and found satisfactory. The optimized formulation F8 containing HPMC (Metolose SR 90SH-15000) and xanthan gum (1:2) and in vitro drug release study showed sustained drug released for 9 Hours. Optimization study was performed by using design of experiment (DoE). In vitro drug release study data revealed that combination of Metolose SR 90SH-15000 (30 mg) and Xanthan Gum (60 mg) along with diluent dibasic calcium phosphate (41 mg) shown desired drug release profile with sustained manner. The approach describes the efficiency of bioadhesive polymer to adhere the mucous lining and prolong the drug release. Backing layer of ethyl cellulose (EC) was used to provide unidirectional drug release. The in vitro release kinetics reveals that formulation follows Korsmeyer–Peppas model. Optimized formulation was stable for1 month accelerated stability condition at 40°C and 75% RH. PubDate: 2022-07-28 Issue No:Vol. 13, No. 2 (2022)
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Authors:M. Sushma, S. Lahari, B. Jayanthi Pages: 1 - 6 Abstract: This study aims to extract the phytochemical constituents and in-vitro evaluation of antiulcer activity of Hemigraphis colorata (Acanthaceae) Commonly known as red flameivy, belongs to the family Acanthaceae. Used to advance pee, checkhemorrhage, stopdysentery, treat veneral sicknesses and to recuperate hemorrhoids. Preliminary phytochemical screening revealed the presence of the leaves contain flavonoids, polyphenols, tannins, high potassium and low sodium levels; stem contains saponins and tannins, roots contain flavonoids and polyphenols. This study has taken with the antiulcer activity and preliminary phytochemical screening on the Hemigraphis colorata. In the present study, qualitative study of the phytochemicals present in the sample was determined, antiulcer were carried out. On the premise of the prevailing study, the outcomes eventually concluded that the ethanolic extract of Hemigraphis colorata own antiulcer pastime. This evaluation offers an concept that the compound of the plant Hemigraphis colorata may be used as lead compound for designing other diseases. PubDate: 2022-05-23 DOI: 10.37591/(rrjops).v13i1.1168 Issue No:Vol. 13, No. 1 (2022)
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Authors:S K Godasu, S. A. Sreenivas Pages: 7 - 15 Abstract: Objective: A New method was established for simultaneous estimation of Gallic acid and curcumin by RP-HPLC method. Methods: Chromatographic separations were performed on an Inspire (4.6 x 150mm, 5m) column with a mobile phase composition of 0.1 percent OPA buffer and Acetonitrile (30:70) delivered at a flow rate of 1 ml/min, and detection was performed on a waters HPLC auto sampler, separation module 2695 with PDA detector 2996 at wavelength 260 nm. Results: The retention time for Gallic acid and curcumin were 2.119 and 2.730 minute respectively. The linearity correlation coefficients for Gallic acid and curcumin were 0.999 and the concentration ranges were 500-2500 g/ml and 5-25 g/ml, respectively. For accuracy the total recovery was found to be 100.58% and 100.54% for Gallic acid and curcumin. LOD and LOQ for gallic acid 3.05 and 10.07. LOD and LOQ for Curcumin 2.28 and 9.98. Conclusion: The study's findings revealed that the suggested RPHPLC method is a simple, accurate, precise, rugged, robust, rapid, and repeatable method for routinely estimating Gallic acid and curcumin in pharmaceutical dose form. PubDate: 2022-05-23 Issue No:Vol. 13, No. 1 (2022)
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Authors:Gyanendra Kumar Gupta, Gagan Devi Pages: 16 - 22 Abstract: Sarpagandha is a evergreen shrub belong to Apocyanaceae. It is a medicinal plant used in Ayurvedic and Modern system of Medicine. Rauwolfia serpentina hold central position in world of pharmaceutical science due to presence of various alkaloids. This herb consist of number of active principle which have medicinal value so used in many disorders of various system. PubDate: 2022-05-23 Issue No:Vol. 13, No. 1 (2022)
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Authors:Gyanendra Kumar Gupta, Gagan Devi Pages: 23 - 29 Abstract: Tribulus terrestris is a perennial plant, grown predominantly in in India and Africa. Its extract contains alkaloids; Saponins. Resins, flavonoids and nitrates. A review was conducted to gather information on various aspects of Gokshura in light of its therapeutic efficacy. This plant's clinical and pharmacological evaluation was based on bedside Ayurvedic references. PubDate: 2022-05-23 Issue No:Vol. 13, No. 1 (2022)
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Authors:Bhusari Vishwas M, Kamble H., Sagade Vaibhav B, Waghmare Santosh Pages: 30 - 35 Abstract: HPLC is a critical analytical method for obtaining medicinal product information. The HPLC method should be capable of separating, detecting, and quantifying a variety of medicines and associated compounds. Validation is the process of determining the performance and qualities of a product or service. In this paper, I assembled HPLC data using their QbD method. It is more efficient than traditional HPLC. This is the most versatile, safe, reliable, and quick chromatographical method for drug sample quality control. The goal of this study was to concentrate on many aspects of HPLC, such as its principle, kinds, apparatus, HPLC method creation, and validation, as well as its application. PubDate: 2022-05-23 DOI: 10.37591/(rrjops).v13i1.1169 Issue No:Vol. 13, No. 1 (2022)
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