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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted alphabetically
Microbial Drug Resistance     Hybrid Journal   (Followers: 3)
Molecular Informatics     Hybrid Journal   (Followers: 5)
Molecular Pharmacology     Hybrid Journal   (Followers: 2)
Molekul     Open Access  
Natural Product Communications     Open Access  
Nature Reviews Drug Discovery     Full-text available via subscription   (Followers: 311)
Naunyn-Schmiedeberg's Archives of Pharmacology     Hybrid Journal  
NeuroMolecular Medicine     Hybrid Journal  
Neuropharmacology     Hybrid Journal   (Followers: 5)
Neuropsychopharmacology     Hybrid Journal   (Followers: 17)
Neuropsychopharmacology Reports     Open Access  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Drug Design & Delivery     Open Access  
OA Medical Hypothesis     Open Access  
Obesity Facts     Open Access   (Followers: 8)
Open Pharmacoeconomics & Health Economics Journal     Open Access   (Followers: 1)
Open Pharmacology Journal     Open Access  
OpenNano     Open Access   (Followers: 1)
Orbital - The Electronic Journal of Chemistry     Open Access   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Pain and Therapy     Open Access   (Followers: 3)
Particulate Science and Technology: An International Journal     Hybrid Journal   (Followers: 1)
PDA Journal of Pharmaceutical Science and Technology     Full-text available via subscription   (Followers: 33)
Pediatric Drugs     Full-text available via subscription   (Followers: 3)
Pediatric Pharmacology     Open Access   (Followers: 1)
Pharmaceutica Analytica Acta     Open Access  
Pharmaceutical Biology     Open Access  
Pharmaceutical Care-La Farmacoterapia     Open Access  
Pharmaceutical Chemistry Journal     Hybrid Journal  
Pharmaceutical Development and Technology     Hybrid Journal   (Followers: 19)
Pharmaceutical Executive     Full-text available via subscription   (Followers: 2)
Pharmaceutical Fronts     Open Access   (Followers: 8)
Pharmaceutical Historian     Open Access  
Pharmaceutical Journal     Free   (Followers: 8)
Pharmaceutical Journal of Sri Lanka     Open Access  
Pharmaceutical Medicine     Full-text available via subscription   (Followers: 4)
Pharmaceutical Nanotechnology     Hybrid Journal  
Pharmaceutical Patent Analyst     Full-text available via subscription   (Followers: 3)
Pharmaceutical Research     Hybrid Journal   (Followers: 93)
Pharmaceutical Statistics     Hybrid Journal   (Followers: 15)
Pharmaceutical Technology     Full-text available via subscription   (Followers: 6)
Pharmaceuticals     Open Access   (Followers: 4)
Pharmacia     Open Access  
Pharmaciana     Open Access  
PharmacoEconomics     Full-text available via subscription   (Followers: 25)
PharmacoEconomics & Outcomes News     Full-text available via subscription   (Followers: 2)
PharmacoEconomics German Research Articles     Full-text available via subscription  
PharmacoEconomics Spanish Research Articles     Hybrid Journal   (Followers: 1)
Pharmacoepidemiology and Drug Safety     Hybrid Journal   (Followers: 33)
Pharmacogenetics and Genomics     Hybrid Journal   (Followers: 1)
Pharmacogenomics     Hybrid Journal   (Followers: 7)
Pharmacogenomics and Personalized Medicine     Open Access   (Followers: 2)
Pharmacogenomics Journal     Hybrid Journal   (Followers: 5)
Pharmacognosy Communications     Partially Free  
Pharmacognosy Magazine     Open Access   (Followers: 2)
Pharmacognosy Research     Open Access   (Followers: 2)
Pharmacological Reports     Hybrid Journal  
Pharmacological Research     Hybrid Journal   (Followers: 1)
Pharmacological Research - Modern Chinese Medicine     Open Access  
Pharmacological Reviews     Hybrid Journal   (Followers: 2)
Pharmacology     Full-text available via subscription  
Pharmacology & Therapeutics     Hybrid Journal   (Followers: 3)
Pharmacology & Pharmacy     Open Access   (Followers: 1)
Pharmacology Biochemistry and Behavior     Hybrid Journal   (Followers: 2)
Pharmacology Research & Perspectives     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacopsychiatry     Hybrid Journal   (Followers: 3)
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy     Hybrid Journal   (Followers: 37)
Pharmactuel     Open Access   (Followers: 1)
Pharmacy     Open Access   (Followers: 4)
Pharmacy & Pharmacology     Open Access   (Followers: 1)
Pharmacy Education     Full-text available via subscription   (Followers: 11)
Pharmacy Practice (Internet)     Open Access   (Followers: 8)
Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
PharmaNutrition     Hybrid Journal   (Followers: 3)
PharmaTutor     Open Access  
Pharmazeutische Industrie     Full-text available via subscription   (Followers: 9)
Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 11)
Pharmazie in Unserer Zeit (Pharmuz)     Hybrid Journal   (Followers: 11)
Physiology International     Full-text available via subscription   (Followers: 3)
Plant Products Research Journal     Full-text available via subscription  
Planta Medica     Hybrid Journal   (Followers: 4)
Planta Medica International Open     Open Access  
Prescriber     Hybrid Journal   (Followers: 9)
Progress in Neuro-Psychopharmacology and Biological Psychiatry     Hybrid Journal   (Followers: 8)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Psychopharmacology     Hybrid Journal   (Followers: 15)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Redox Report     Open Access  
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 41)
Research & Reviews : A Journal of Drug Design & Discovery     Full-text available via subscription  
Research & Reviews : A Journal of Pharmaceutical Science     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacognosy     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacology     Full-text available via subscription   (Followers: 1)
Research in Pharmaceutical Sciences     Open Access   (Followers: 3)
Research in Social and Administrative Pharmacy     Hybrid Journal   (Followers: 3)
Research Journal of Pharmacognosy     Open Access  
Research Results in Pharmacology     Open Access  
Reviews of Physiology, Biochemistry and Pharmacology     Hybrid Journal   (Followers: 4)
Reviews on Clinical Pharmacology and Drug Therapy     Full-text available via subscription  
Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Revista Cubana de Plantas Medicinales     Open Access   (Followers: 1)
Revista de Ciências Farmacêuticas Básica e Aplicada     Open Access  
Revista Mexicana de Ciencias Farmaceuticas     Open Access  
Revue de Médecine et de Pharmacie     Full-text available via subscription  
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Saudi Pharmaceutical Journal     Open Access  
Scandinavian Journal of Clinical and Laboratory Investigation     Hybrid Journal   (Followers: 7)
Scientia Pharmaceutica     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Seminars in Oncology Nursing     Full-text available via subscription   (Followers: 10)
Separation Science plus (SSC plus)     Hybrid Journal  
Side Effects of Drugs Annual     Full-text available via subscription   (Followers: 2)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 6)
Substance Abuse : Research and Treatment     Open Access   (Followers: 5)
Suchttherapie     Hybrid Journal   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 5)
SynOpen     Open Access  
The Botulinum J.     Hybrid Journal  
The Brown University Psychopharmacology Update     Hybrid Journal   (Followers: 2)
The Medical Letter     Full-text available via subscription   (Followers: 18)
The Pink Sheet     Full-text available via subscription   (Followers: 12)
The Pink Sheet Daily     Full-text available via subscription   (Followers: 4)
Therapeutic Advances in Drug Safety     Open Access   (Followers: 3)
Therapeutic Advances in Psychopharmacology     Open Access   (Followers: 4)
Therapeutic Advances in Vaccines     Hybrid Journal   (Followers: 1)
Therapeutic Drug Monitoring     Hybrid Journal   (Followers: 3)
Therapeutic Innovation & Regulatory Science     Hybrid Journal   (Followers: 7)
Thérapie     Full-text available via subscription   (Followers: 1)
TheScientist     Free   (Followers: 5)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Toxicological Research     Hybrid Journal  
Toxicological Sciences     Hybrid Journal   (Followers: 11)
Toxicology     Hybrid Journal   (Followers: 18)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 24)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Toxicology in Vitro     Hybrid Journal   (Followers: 11)
Toxicology International     Full-text available via subscription   (Followers: 5)
Toxicology Letters     Hybrid Journal   (Followers: 15)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 7)
Toxicology Research     Partially Free   (Followers: 8)
Toxicon     Hybrid Journal   (Followers: 5)
Toxicon : X     Open Access  
Toxin Reviews     Hybrid Journal  
Translational Psychiatry     Open Access   (Followers: 14)
Trends in Peptide and Protein Sciences     Open Access  
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 19)
Tropical Journal of Pharmaceutical Research     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Vascular Pharmacology     Hybrid Journal   (Followers: 2)
World Mycotoxin Journal     Hybrid Journal   (Followers: 3)
Yakugaku Zasshi     Open Access   (Followers: 1)
Zeitschrift für Phytotherapie     Hybrid Journal   (Followers: 1)
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
Фармацевтичний часопис     Open Access  

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Orbital - The Electronic Journal of Chemistry
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1984-6428 - ISSN (Online) 1984-6428
Published by Universidade Federal de Mato Grosso do Sul Homepage  [1 journal]
  • Production and Characterization of Craft Beers with Addition of
           Campomanesia adamantium O. Berg Fruits and Leave

    • Authors: Maria Helena Verdan, Maria do Socorro Mascarenhas Santos, Thiago Luis Aguayo de Castro, Claudia Andrea Lima Cardoso
      Abstract: The increase in the consumption of craft beer is drawing attention to its characteristics. The search for compounds or products that increase stability and guarantee the quality of the beer is fundamental. Here is presented the preparation of two craft beers with the addition of aqueous extract of leaves or fruits of Campomanesia adamantium since this species is known for having a high antioxidant activity. Volatiles compounds and phenolic content, pH, colour and antioxidant action were determined for the samples. The results show that the alcohol content and the number of volatile compounds are on average for most beers. The sample prepared with C. adamantium fruits has a higher content of phenolic compounds and antioxidant potential, compared to the sample added with the aqueous extract of the leaves. Fruits of C. adamantium increased the antioxidant action of craft beers by 79.1%. 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1690 
      PubDate: 2022-03-28
      Issue No: Vol. 14 (2022)
       
  • FPolymer: A Program for 3D Structure Generation and OPLS Topology of
           Polymers with High Molecular Mass

    • Authors: Fabricio Uliana, Eloi Alves Silva Filho, Arlan da Silva Gonçalves, Vadilson Malaquias dos Santos, Mateus Uliana
      Abstract: The need to study polymeric systems with high molecular masses by techniques such as molecular dynamics using free-use software, coupled with the difficulty of parameterizing such systems, led to the creation of the FPolymer program. This program was built in C++ language using the QT-creator framework and has a simple and intuitive interface. The main function of the program is to use previously parameterized trimers of any polymer to generate a structure with the number of repeating units indicated by the user. As output of the program, the user receives a file <file>.pdb containing the structure of the polymer and a file <file>.top with the topology prepared to perform youngest molecular dynamics in the GROMAS program. 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1698  
      PubDate: 2022-03-28
      Issue No: Vol. 14 (2022)
       
  • Identification of Science Teacher Practices and Barriers in Preparation of
           Minimum Competency Assessment in the Covid-19 Pandemic Era

    • Authors: Hayuni Retno Widarti, Deni Ainur Rokhim, Maya Oki Septiani, Mohammad Hilfi Azra Dzikrulloh
      Abstract: The Minister of Education, Culture, Research, and Technology made a new policy that from 2021, a national assessment that will be held is minimum competency assessment or commonly known as AKM. AKM is measuring two basic skills that are literacy and numeracy. The occurrence of the Covid-19 pandemic has affected the implementation of education. The learning that was originally face-to-face in the classroom now must be changed to online system. This is causes delays in the preparation of minimum competency assessment. Therefore, this research is important to do so that teachers, schools, and the government have a strategy in preparing minimum competency assessments in the era of the pandemic and post-covid-19 pandemic. This study aims to identify the practices and barriers of science teachers in preparation for the minimum competency assessment during the Covid-19 pandemic. This study uses a qualitative descriptive research method with four stages of research, that is preparation, data collection, data analysis, and concluding. The subject in this research included 15 science teachers from East Java, Indonesia. Subject selection was carried out using criterion-based selection and sample determination using cluster sampling technique. The instrument uses consist of an open and closed questionnaire via a google form. Data was analyzed using descriptive statistical techniques. The result showed that in online learning, most teachers had implemented learning that oriented to the preparation of minimum competency assessment but had not shown a positive correlation to student learning outcomes. 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1695

      PubDate: 2022-03-28
      Issue No: Vol. 14 (2022)
       
  • Utilization of Banana Stem Waste Extracts Assisted by Electrode of Cu/Mg
           as an Environmentally Friendly Electricity Producer

    • Authors: Deni Ainur Rokhim, Ahmad Wahani Adid, Frida Kristining Tyas, Endang Ciptawati, Muhammad Roy Asrori
      Abstract: The high consumption of electricity from year to year and the depletion of the availability of fossil energy have triggered an increase in energy prices and scarcity of fossil resources. This problem gives a strong impetus to seek alternative energy sources that are environmentally friendly. One of the recent technologies is the Microbial Fuel Cell (MFC) on banana stem, which can convert chemical energy into electrical energy. The purpose of this study was to determine the potential of banana stem waste extract assisted by Cu/Mg electrodes as a source of electricity as well as how the manufacturing and testing methods, and the effect of variations in the volume of banana stem extracts on the performance of electrical energy. The used steps were electrode preparation and banana stem waste preparation, then incubating the banana stem waste for 7 days, assembling the construction for research on the potential of the banana stem waste as a power producer, and research with variations in the volume of the extract and testing its strength, electric current, electric voltage, and power density. Based on the research, it was found that the greater the volume of the extract of banana stem, the greater the power density, electric voltage, and also the strong electric current produced. The volume variation of 130 mL produced a voltage of 500 mVolt, a strong current of 0.86 mA, and a power density of 84 (mW/cm2). 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1677


      PubDate: 2022-03-27
      Issue No: Vol. 14 (2022)
       
  • Effect of Exchange–correlation Functionals on Ground State Geometries,
           Optoelectronic and Charge Transfer of Triphenylamine-based Dyes

    • Authors: Malak Lazrak, Hamid Toufik, Sliman Ennehary, Si Mohamed Bouzzine, Fatima Lamchouri
      Abstract: The importance of the Density Functional Theory (DFT) calculation approach lies in their ability to provide a highly accurate prediction of structural and optoelectronic properties. However, the traditional methods of DFT failed to predict optoelectronic properties satisfactorily. Therefore, it will be necessary to examine methods containing different percentages of Hartree-Fock exchange and correlation in order to find the most suitable functionals. DFT and Time-Dependent-DFT (TD-DFT) calculations was carried out using four different functionals approximations incorporating a different amount of Hartree Fock exchange (B3LYP, BHandHLYP, CAM-B3LYP and LCωPBE), in order to evaluate their accuracies to predict the geometrical, optoelectronic and charge transfer properties of four triphenylamine-based dyes for Dye-Sensitized Solar Cells (DSSCs) applications. The functional hybrid B3LYP was the best among adopted functional that reproduced the geometrical, optoelectronic and charge transfer properties. On the other hand, it has been shown that the Hartree-Fock exchange percentage for BHandHLYP, significantly improved TD-DFT results in the case of organic dyes. Moreover, the corrected long-range functionals (CAM-B3LYP and LC-wPBE) present valuable tools for giving results of comparable precision with experimental optical data. In terms of the choice of the most appropriate functional for computational calculation, the obtained results can be useful for future DSSC applications. 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1682 
      PubDate: 2022-03-27
      Issue No: Vol. 14 (2022)
       
  • Synthesis, X-Ray Diffraction (XRD), Differential Thermal Analysis (DTA),
           and Scanning Electron Microscopy (SEM) of the Alloy (CuInTe2)1-x(NbTe)x
           with x=0.5

    • Authors: Gerzon E. Delgado, Miguel Palmera, Pedro Grima-Gallardo, Miguel Quintero
      Abstract: A polycrystalline ingot (30mm long, 10mm diameter) of the alloy (CuInTe2)1-x(NbTe)x with x=0.5 has been produced using the melt and anneal technique and characterized by X-Ray Diffraction (XRD), Diferential Thermal Analysys (DTA) and Scanning Electron Microscopy (SEM). From XRD results, and using Rietveld refinement method, the crystal structure has been obtained indicating than this alloy crystallizes in a chalcopyrite-like structure, space group  (Nº 112), unit cell parameters a = 6.1933(2) Å, c = 12.4293(2) Å, V = 476.75(2) Å3, figures of merit Rexp= 6.7%, Rp= 7.5%, Rwp= 7.3%, and S = 1.1. DTA measurements indicate three thermal transitions at 1028, 977 and 886 K in the heating cycle, and 1016, 900 and 848 K in the cooling. The transitions at 1028 and 1016 correspond to the melting and solidification point, respectively; the transitions at 977 and 900 K are of solid to liquid+solid type, whereas the transitions at 886 and 848 K correspond to order-disorder. The melting point is incongruent. In the diffraction pattern, traces of a secondary phase are observed; this phase has been identified using SEM technique as (CuIn)0.5NbTe2. 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1670 
      PubDate: 2022-03-26
      Issue No: Vol. 14 (2022)
       
  • 3D-QSAR, ADMET and Docking Studies for Design New
           5,5-Diphenylimidazolidine-2,4-dione Derivatives Agents Against Cervical
           Cancer

    • Authors: Reda El-Mernissi, Khalil El khatabi, Ayoub Khaldan, Soukaina Bouamrane, Larbi ElMchichi, Mohammed Aziz Ajana, Tahar Lakhlifi, Mohammed Bouachrine
      Abstract: Cancer is one of the world's causes of death, which requires the discovery of new molecules likely to become anticancer drugs. In this study, a three–dimensional quantitative structure-activity relationship is employed to study eighteen compounds of 5,5-diphenylimidazolidine-2,4-dione derivatives against cancer cell lines HeLa, their pIC50 varied from 3.62 to 5.00. In addition, the 3D-QSAR model was defined on the basis of Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices (CoMSIA) analysis, the model achieved strong predictability with the model CoMFA is (Q2 =0.70; R2 =0.94; r2 test =0.96) and the best one on CoMSIA (Q2 =0.73; R2 =0.97; r2 test= 0.98), respectively. We have proposed four compounds with highly potent anticancer predicted activities, based on successful results obtained by the contour maps formed by the method model. Furthermore, the ADMET properties of these newly designed compounds were in silico evaluated, among which two derivatives have respected these properties. These compounds were further evaluated by molecular docking, showing that two molecules T2 and T4 exhibit favorable interactions with the targeted receptor and a high total score. These findings may afford valuable more information to design compounds anticancer activity against Hela cells. 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1659 
      PubDate: 2022-03-25
      Issue No: Vol. 14 (2022)
       
  • Bilastine Based Drugs as SARS-CoV-2 Protease Inhibitors: Molecular
           Docking, Dynamics, and ADMET Related Studies

    • Authors: Ajoy Kumer, Unesco Chakma, Mohammed M. Matin
      Abstract: Bilastine drugs, structurally piperidine-1-carboxylate and sulfonyloxyethyl carboxylate derivatives, have significantly been employed as the medication of second-generation antihistamine drugs, and are used for the treatment of allergic rhinoconjunctivities and urticarial (hives). The bilastine drugs, composed of benzene carboxylate, propanoate, carboxylate, methyl-sulfonate, propanoic acid, butanoic acid, and pentanoic acid derivatives, were investigated through computational tools against SARS-CoV-2. The COVID-19 virus consists of five proteases where the curial function is performed by main proteases (Mpro) and Spike proteases (Spro). The Mpro and Spro were selected for calculation of molecular docking by these bilastine drugs which showed higher binding energy (<-6.5 kcal/mol) for both proteases. The main carboxylic acid group in bilastine drugs is found the primary key for a high binding score to show the large binding affinity with Mpro and Spro, and is highly responsible for forming the hydrogen bond although the various hydrophobic bonds were produced as a weak interaction. For justification, the stability of molecular docked ligand-protein complexes was investigated with molecular dynamics. It showed that the root mean square deviation (RMSD) and root mean square fluctuation (RMSF) of all these drugs were below the 0.9 Å after residue interaction. Moreover, the HOMO-LUMO gap, hardness, and softness provided full details for their chemical reactivity. In this view, the pharmacokinetics and Lipinski rule were calculated, and all of these molecules had satisfied the Lipinski rule. Finally, using the admetSAR online database, absorption, distribution, metabolism, excretion, and toxicity have been calculated which indicated that these bilastine drugs are non-carcinogenic and less harmful for both aquatic and non-aquatic species. 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1642
      PubDate: 2022-03-23
      Issue No: Vol. 14 (2022)
       
  • Recovery of Rare-Earth Elements from Brazilian Ion-Adsorption Clay: A
           Preliminary Study

    • Authors: Ellen Cristine Giese, Ana Carolina S. P. de Souza
      Abstract: Ion-adsorption clays (IAC) are alumino-silicate ores, considered an essential source of heavy rare-earth elements (REE). With the increasing discovery and exploitation of IAC deposits, the present work sought to evaluate different methods of solubilization of REE through the use of different concentrations of inorganic acids (H2SO4, HCl, and HNO3), as well as different concentrations of ammonium sulfate and lactic acid. According to the results, the sulfuric acid solution favored the solubilization of both La3+ and Sm3+ elements. The solubilization of REE in the presence of ammonium sulfate showed no significant differences as a function of the leaching time but favored the solubilization of Y3+ and Tb3+. More efficient solubilization of Sm3+ was observed with the addition of lactic acid at a concentration of 30 g L-1, leading to 90% (4.5 ppm) of Sm3+ extraction. The solubilization of La3+ was favored by the contact time, with higher Sm3+ extraction yields in 14 days of leaching. 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1569
      PubDate: 2022-03-20
      Issue No: Vol. 14 (2022)
       
  • Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of
           2,4-Diaryl-quinoline Derivatives in Water

    • Authors: Lucas Michelão Martins, Vitor Fernandes Moreno, Ilana Sganzerla Rosário, Carlos Frederico de Oliveira Graeff, Luiz Carlos Silva Filho
      Abstract: Quinolines are an important class of natural and synthetic products, with several biological activity and applications in medicine and electronics. In this work we present a greener method of synthesis of 2,4-diaryl-quinoline derivatives by an easy one-pot multicomponent reaction between aniline derivatives, aldehyde derivatives and phenylacetylene in water, with hydrochloric acid as promoter. With this method we could synthesize several compounds with good yield and reaction time, including new alkylamino-containing 2,4-diaryl-quinoline derivatives that could not be synthesized with niobium pentachloride catalyst in similar conditions. 
      DOI : http://dx.doi.org/10.17807/orbital.v14i1.1689 
      PubDate: 2022-03-18
      Issue No: Vol. 14 (2022)
       
 
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