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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted alphabetically
Microbial Drug Resistance     Hybrid Journal   (Followers: 3)
Molecular Informatics     Hybrid Journal   (Followers: 5)
Molecular Pharmacology     Hybrid Journal   (Followers: 2)
Molekul     Open Access   (Followers: 1)
Natural Product Communications     Open Access  
Nature Reviews Drug Discovery     Full-text available via subscription   (Followers: 315)
Naunyn-Schmiedeberg's Archives of Pharmacology     Hybrid Journal  
NeuroMolecular Medicine     Hybrid Journal  
Neuropharmacology     Hybrid Journal   (Followers: 6)
Neuropsychopharmacology     Hybrid Journal   (Followers: 18)
Neuropsychopharmacology Reports     Open Access  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Drug Design & Delivery     Open Access  
OA Medical Hypothesis     Open Access  
Obesity Facts     Open Access   (Followers: 8)
Open Pharmacoeconomics & Health Economics Journal     Open Access  
Open Pharmacology Journal     Open Access  
OpenNano     Open Access   (Followers: 1)
Orbital - The Electronic Journal of Chemistry     Open Access   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Pain and Therapy     Open Access   (Followers: 3)
Particulate Science and Technology: An International Journal     Hybrid Journal   (Followers: 1)
PDA Journal of Pharmaceutical Science and Technology     Full-text available via subscription   (Followers: 36)
Pediatric Drugs     Full-text available via subscription   (Followers: 4)
Pediatric Pharmacology     Open Access   (Followers: 1)
Pharmaceutica Analytica Acta     Open Access  
Pharmaceutical Biology     Open Access  
Pharmaceutical Care-La Farmacoterapia     Open Access  
Pharmaceutical Chemistry Journal     Hybrid Journal  
Pharmaceutical Development and Technology     Hybrid Journal   (Followers: 21)
Pharmaceutical Executive     Full-text available via subscription   (Followers: 6)
Pharmaceutical Fronts     Open Access   (Followers: 4)
Pharmaceutical Historian     Open Access  
Pharmaceutical Journal     Free   (Followers: 7)
Pharmaceutical Journal of Sri Lanka     Open Access  
Pharmaceutical Medicine     Full-text available via subscription   (Followers: 4)
Pharmaceutical Nanotechnology     Hybrid Journal  
Pharmaceutical Patent Analyst     Full-text available via subscription   (Followers: 3)
Pharmaceutical Research     Hybrid Journal   (Followers: 97)
Pharmaceutical Statistics     Hybrid Journal   (Followers: 16)
Pharmaceutical Technology     Full-text available via subscription   (Followers: 6)
Pharmaceuticals     Open Access   (Followers: 4)
Pharmacia     Open Access  
PharmacoEconomics     Full-text available via subscription   (Followers: 26)
PharmacoEconomics & Outcomes News     Full-text available via subscription   (Followers: 4)
PharmacoEconomics German Research Articles     Full-text available via subscription  
PharmacoEconomics Spanish Research Articles     Hybrid Journal   (Followers: 1)
Pharmacoepidemiology and Drug Safety     Hybrid Journal   (Followers: 34)
Pharmacogenetics and Genomics     Hybrid Journal   (Followers: 1)
Pharmacogenomics     Hybrid Journal   (Followers: 7)
Pharmacogenomics and Personalized Medicine     Open Access   (Followers: 2)
Pharmacogenomics Journal     Hybrid Journal   (Followers: 5)
Pharmacognosy Communications     Partially Free  
Pharmacognosy Magazine     Open Access   (Followers: 2)
Pharmacognosy Research     Open Access   (Followers: 2)
Pharmacological Reports     Hybrid Journal  
Pharmacological Research     Hybrid Journal   (Followers: 1)
Pharmacological Research - Modern Chinese Medicine     Open Access  
Pharmacological Reviews     Hybrid Journal   (Followers: 1)
Pharmacology     Full-text available via subscription  
Pharmacology & Therapeutics     Hybrid Journal   (Followers: 3)
Pharmacology & Pharmacy     Open Access   (Followers: 1)
Pharmacology Biochemistry and Behavior     Hybrid Journal   (Followers: 2)
Pharmacology Research & Perspectives     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacopsychiatry     Hybrid Journal   (Followers: 3)
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy     Hybrid Journal   (Followers: 37)
Pharmactuel     Open Access   (Followers: 1)
Pharmacy     Open Access   (Followers: 4)
Pharmacy & Pharmacology     Open Access  
Pharmacy Education     Full-text available via subscription   (Followers: 11)
Pharmacy Practice (Internet)     Open Access   (Followers: 7)
Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
PharmaNutrition     Hybrid Journal   (Followers: 2)
PharmaTutor     Open Access  
Pharmazeutische Industrie     Full-text available via subscription   (Followers: 11)
Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 15)
Pharmazie in Unserer Zeit (Pharmuz)     Hybrid Journal   (Followers: 18)
Physiology International     Full-text available via subscription   (Followers: 3)
Plant Products Research Journal     Full-text available via subscription  
Planta Medica     Hybrid Journal   (Followers: 4)
Planta Medica International Open     Open Access  
Prescriber     Hybrid Journal   (Followers: 9)
Progress in Neuro-Psychopharmacology and Biological Psychiatry     Hybrid Journal   (Followers: 8)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Psychopharmacology     Hybrid Journal   (Followers: 16)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Redox Report     Open Access  
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 41)
Research & Reviews : A Journal of Drug Design & Discovery     Full-text available via subscription  
Research & Reviews : A Journal of Pharmaceutical Science     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacognosy     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacology     Full-text available via subscription   (Followers: 1)
Research in Pharmaceutical Sciences     Open Access   (Followers: 3)
Research in Social and Administrative Pharmacy     Hybrid Journal   (Followers: 3)
Research Journal of Pharmacognosy     Open Access  
Research Results in Pharmacology     Open Access  
Reviews of Physiology, Biochemistry and Pharmacology     Hybrid Journal   (Followers: 4)
Reviews on Clinical Pharmacology and Drug Therapy     Full-text available via subscription  
Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Revista Cubana de Plantas Medicinales     Open Access   (Followers: 1)
Revista de Ciências Farmacêuticas Básica e Aplicada     Open Access  
Revista Mexicana de Ciencias Farmaceuticas     Open Access  
Revue de Médecine et de Pharmacie     Full-text available via subscription  
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Saudi Pharmaceutical Journal     Open Access  
Scandinavian Journal of Clinical and Laboratory Investigation     Hybrid Journal   (Followers: 8)
Scientia Pharmaceutica     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Seminars in Oncology Nursing     Full-text available via subscription   (Followers: 10)
Separation Science plus (SSC plus)     Hybrid Journal  
Side Effects of Drugs Annual     Full-text available via subscription   (Followers: 2)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 6)
Substance Abuse : Research and Treatment     Open Access   (Followers: 5)
Suchttherapie     Hybrid Journal   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 5)
SynOpen     Open Access  
The Botulinum J.     Hybrid Journal  
The Brown University Psychopharmacology Update     Hybrid Journal   (Followers: 2)
The Medical Letter     Full-text available via subscription   (Followers: 18)
The Pink Sheet     Full-text available via subscription   (Followers: 12)
The Pink Sheet Daily     Full-text available via subscription   (Followers: 5)
Therapeutic Advances in Drug Safety     Open Access   (Followers: 3)
Therapeutic Advances in Psychopharmacology     Open Access   (Followers: 4)
Therapeutic Advances in Vaccines     Hybrid Journal   (Followers: 1)
Therapeutic Drug Monitoring     Hybrid Journal   (Followers: 5)
Therapeutic Innovation & Regulatory Science     Hybrid Journal   (Followers: 7)
Thérapie     Full-text available via subscription   (Followers: 1)
TheScientist     Free   (Followers: 6)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Toxicological Research     Hybrid Journal  
Toxicological Sciences     Hybrid Journal   (Followers: 11)
Toxicology     Hybrid Journal   (Followers: 19)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 25)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Toxicology in Vitro     Hybrid Journal   (Followers: 12)
Toxicology International     Full-text available via subscription   (Followers: 5)
Toxicology Letters     Hybrid Journal   (Followers: 16)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 9)
Toxicology Research     Partially Free   (Followers: 8)
Toxicon     Hybrid Journal   (Followers: 5)
Toxicon : X     Open Access  
Toxin Reviews     Hybrid Journal  
Translational Psychiatry     Open Access   (Followers: 14)
Trends in Peptide and Protein Sciences     Open Access  
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 21)
Tropical Journal of Pharmaceutical Research     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Vascular Pharmacology     Hybrid Journal   (Followers: 2)
World Mycotoxin Journal     Hybrid Journal   (Followers: 3)
Yakugaku Zasshi     Open Access   (Followers: 1)
Zeitschrift für Phytotherapie     Hybrid Journal   (Followers: 1)
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
Фармацевтичний часопис     Open Access  

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Oriental Pharmacy and Experimental Medicine
Journal Prestige (SJR): 0.169
Number of Followers: 2  
 
  Partially Free Journal Partially Free Journal
ISSN (Print) 1598-2386 - ISSN (Online) 2211-1069
Published by Springer-Verlag Homepage  [2469 journals]
  • Antimicrobial evaluation and molecular docking studies of Swertiamarin and
           Quercetin targeting dihydropteroate synthase enzyme

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      Abstract: Present study was aimed to evaluate synergistic antimicrobial activity of iridoid (Swertiamarin) and flavonoid glycoside (Quercetin). Swertiamarin (Sw) was isolated from methanol extract of Enicostemma axillare and quercetin (Qu) was purchased. The antimicrobial activity of Sw, Qu and combination of swertiamarin and quercetin (SQC) was evaluated against Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Methicillin resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans using turbidimetric method. Molecular docking study of Sw and Qu was done on the target site of dihydropteroate synthase (DHPS) of protein data bank (PDB) ID: 3TYC (Dihydropteroate Synthase in complex with DHP +). Sw and Qu exhibited good antimicrobial activity in all the tested microorganisms at lower concentration (2.5 µg/ml). The SQC displayed significant antimicrobial activity and found high percentage of inhibition and comparable to standard ciprofloxacin. In molecular docking study, Sw and Qu have found good binding energy and interaction energy with the selected target site of DHPS of 3TYC. Graphical abstract
      PubDate: 2022-05-02
       
  • Potential involvement of opioidergic, α1-adrenergic and serotonergic
           pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich
           (Loranthaceae) in mice

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      Abstract: Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose (LD50) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral LD50 was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways.
      PubDate: 2022-04-27
       
  • In silico profiling of analgesic, antidiarrheal and antihyperglycemic
           properties of Tetrastigma bracteolatum (Wall.) leaves extract supported by
           in vivo studies

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      Abstract: Abstract Hill tract plant Tetrastigma bracteolatum (Wall.) (Family-Vitaceae) is traditionally used for headache, indigestion and stomach disorder by the tribal people in Bangladesh. In this study, the ethanolic leaves extract of TB was investigated for screening its phytochemical constituents and assessing the antioxidant, analgesic, antidiarrheal and antihyperglycemic potential. In DPPH free radical scavenging assay, the extract showed good radical scavenging potential with SC50 (concentration for 50% scavenging) value of 56 µg/ml. Analgesic activity test was performed by acetic acid-induced writhing method, where the extract inhibited writhing by 28.8% and 51.5% at the doses of 250 and 500 mg/kg bw, respectively. The extract inhibited defecation by 36.2% and 60.3% at the doses of 250 and 500 mg/kg bw in castor oil-induced diarrheal mice. In the evaluation of antihyperglycemic activity by oral glucose tolerance test (OGTT), the extract reduced blood glucose levels in a dose-dependent manner after 90 min, compared to the control group. The extract was also assessed for its in vitro α-glucosidase inhibition capacity but no demonstrable effect was observed. Fourteen chemical compounds were identified through GC–MS analysis of the extract with the highest amount of 1,2,3,4,4a,5,8,9,12,12a-decahydro-1,4-methanobenzocyclodecene (5.46%). Few compounds displayed better binding affinity with the active site of NADPH oxidase, nitric oxide synthase, M3 muscarinic acetylcholine receptor and sulfonylurea receptor than standard drugs in molecular docking studies. Therefore, the extract of TB may be used as a potential source of drug leads for various ailments.
      PubDate: 2022-04-22
       
  • Development and evaluation of hydrogel formulation comprising essential
           oil of Mentha longifolia L. for oral candidiasis

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      Abstract: Abstract Mentha longifolia L. is used in folk medicine and its essential oil has antimicrobial and aromatic properties. The present invention relates to the development of hydrogel formulation of Mentha longifolia essential oil (EOML) for treating oral candidiasis. Various EOML hydrogels were developed using mucoadhesive polymers viz., Carbopol 940, sodium carboxymethylcellulose and their blends. The hydrogels were characterized with respect to physical, rheological and textural attributes. Finally, all the EOML based hydrogels were evaluated for in vitro efficacy against Candida albicans employing agar well diffusion and broth dilution assay. The EOML hydrogels were semisolid, off-white color, non-gritty, most stable at 4 and 25 °C, and possessed optimum spreading and pleasing aesthetic attributes. The hydrogels showed pseudo-plastic shear-thinning behaviour and variable viscosity, dependent on the concentration and type of gelling agent. The single polymer-based formulations (F1 and F2) were able to spread better compared to blended polymer formulations (F5 and F6). In broth dilution assay, of all the prepared mucoadhesive hydrogels, F1 (containing 5% Carbopol 940) exhibited lowest MIC value against Candida albicans (ATCC90028 and MTCC277), vis-a-vis EOML and standard drugs (i.e., Amphotericin B and Fluconazole). Further, there was marked enhancement in the antifungal efficacy of F1 in comparison to EOML (20 folds), Amphotericin B (2 folds) and Fluconazole (2 folds). Thus, the hydrogel formulation ensured reduced volatility of EOML and improved its therapeutic effectiveness. Owing to the mucoadhesive components and non-toxic properties of the EOML hydrogel, the formulation can be extended for clinical evaluation for treating oral thrush.
      PubDate: 2022-04-18
       
  • Prospective experimental studies of some herbs used in urinary disorders
           in Unani medicine

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      Abstract: Diseases of the kidney and urinary tract including urolithiasis became a major cause of global illness and death. There are approximately 7.85 million people suffering from chronic renal failure in India. Further, urolithiasis is also a common global phenomenon of renal disorders. Unani Medicine (UM) is a famous kind of conventional medicine practised throughout South Asia that relies on the ancient conventional medicinal systems of India, Egypt, China, Iraq, Syria, and Persia. Berberis vulgaris (BV), Physalis alkekengi (PA) and Boswellia serrata (BS) are very common drugs against urinary disorders in Unani medicine. But, to establish their role to treat in urinary disorders are still obscure. HPTLC fingerprints confirmed the presence of signature compounds according to pharmacopeia. Polyphenolic acids and flavonoids in the test drugs have been quantified by HPLC. BS showed maximum inhibitory action on DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals, nitric oxide and superoxide scavenging than other two test drugs, while, PA have highest hydrogen peroxide scavenging action. In diuretic activity, maximum urination occurred in BS group than other two test drugs BV and PA. The highest excretion of sodium–potassium ratio was noted in PA groups followed by BS and BV. BV showed maximum efficacy in crystal formation in test tubes followed by BS and PA. Graphical abstract
      PubDate: 2022-04-16
       
  • In silico ADMET, molecular docking and molecular simulation-based study of
           glabridin’s natural and semisynthetic derivatives as potential
           tyrosinase inhibitors

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      Abstract: Hyper-pigmentation conditions may develop due to erroneous melanogenesis cascade which leads to excess melanin production. Recently, inhibition of tyrosinase is the main focus of investigation as it majorly contributes to melanin production. This inhibition property can be exploited in medicine, agriculture, and in cosmetics. Present study aims to find a natural and safe alternative molecule as tyrosinase inhibitor. In this study, human tyrosinase enzyme was modelled due to unavailability of its crystal structure to look into the degree of efficacy of glabridin and its 15 derivatives as tyrosinase inhibitor. Docking was performed by Autodock Vina at the catalytic core enzyme. Glabridin effects on melanoma cell lines was also elucidated by analysing cytotoxicity and effect on melanin production. Computational ADME analysis was done by SwissADME. Molecular dynamic simulation was also performed to further evaluate the interaction profile of these molecules and kojic acid (positive inhibitor) with respect to apo protein. Notably, four derivatives 5′-formylglabridin, glabridin dimer, 5′-prenyl glabridin and R-glabridin exhibited better binding affinity than glabridin. Glabridin effectively inhibited melanin production in a dose dependent manner. Among these, 5′-formylglabridin displayed highest binding affinity with docking score − 9.2 kcal/mol. Molecular properties and bioactivity analysis by Molinspiration web server and by SwissADME also presented these molecules as potential drug candidates. The study explores the understanding for the development of suitable tyrosinase inhibitor/s for the prevention of hyperpigmentation. However, a detailed in vivo study is required for glabridin derivatives to suggest these molecules as anti-melanogenic compound. Graphical abstract
      PubDate: 2022-04-11
       
  • Bromelain mediates apoptosis in HeLa cells via ROS-independent pathway

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      Abstract: Abstract Several in vitro studies along with some in vivo studies have shown the anti-cancer activity of bromelain against several types of cancer except cervical cancer. This study is focused to address the therapeutic effect of bromelain on a human cervical cancer cell line in vitro using HeLa cells. Here, the IC50 dose of bromelain enhanced Hela cell apoptosis at a concentration of 100 μg/ml after 48 h treatment, which is statistically significant compared to the dose of 50 μg/ml (p < 0.01). The percentage of live cells was reduced to about 48% and the percentage of apoptotic cells has increased to about 47% at the IC50 dose of bromelain with a 48 h exposure. Significant proportions of HeLa cells were observed to undergo apoptosis via the p53-dependent pathway in a ROS-independent manner at 100 μg/ml after 48 h treatment. In addition to that, bromelain also inhibited the formation of colonies and the migratory ability of HeLa cells. The present study reports that bromelain can act in an apoptotic pathway on human cervical cancer cell line HeLa.
      PubDate: 2022-03-26
       
  • Purified Banana lectin (BanLec) isolated from the ripen pulp of Musa
           Paradisiaca induces apoptosis in cancer cell lines: in vitro study

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      Abstract: The aim of the study was to examine the anticancer activities of banana lectin (BanLec) from the ripen pulp of Musa paradisiaca. In this investigation, we have analyzed the cytotoxicity of BanLec against Vero, HepG2 and THP-1 cell lines. Among these, BanLec exhibited a potent cytotoxicity against THP-1cells, with an IC50 value of 244.38 µg/mL followed by HepG2 with an IC50 of 504.83 µg/mL and no cytotoxic activity towards Vero cells. Moreover, in this study we have evaluated the cell death mechanism induced by BanLec on THP-1cells. These cells were treated with 244.38 µg/mL concentration of BanLec to induce cell death at 24 h incubation. The apoptotic induction was carried out by Annexin V, DAPI staining, TUNEL assay and gene expression studies by qRT-PCR. BanLec induced apoptosis with morphological changes such as cell membrane blebbing, cell shrinkage, chromatin condensation, cell budding and nuclei broken into fragments. The caspase-3 gene expression was upregulated indicating the induction of apoptosis on treatment with BanLec. Using flow cytometry technique, the number of apoptotic cells in G0/G1 phase was evaluated. There was an accumulation and increase in the percentage of cells in G0/G1 phase stating the apoptosis induction against THP-1 cells. On conclusion BanLec showed an apoptosis induction in THP-1 cells in a caspase dependent manner. These collectively results evidently showed that the BanLec exerts cytotoxicity and apoptosis against THP-1 cells. It seems to be one of the potent anticancer compound having a possible therapeutic potential against the human leukemia derived diseases. Graphical abstract
      PubDate: 2022-03-07
       
  • Evaluation of Ylang Ylang essential oil on alcohol induced hepatotoxicity
           in rats

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      Abstract: The present study is aimed to evaluate the effect of ylang ylang essential oil in alcohol induced hepatotoxicity in rats. Alcohol was used as an inducing agent and Silymarin as a standard molecule. Body weight was measured at a 3 days interval till the twenty first day and at the end of the study, serum AST, ALT, TP, TC, TG, and TB biomarkers were estimated. Further, the liver tissue was evaluated for antioxidant enzymes namely CAT, LPO, SOD and GSH level. Liver weight and histopathology was accessed at the end. Phytocompounds were shortlisted from literature and curated databases. Probable targets of each compound were identified using the SwissTargetPrediction web server. Probable mechanisms of phytocompounds against Alcohol induced hepatotoxicity were analyzed by the STRING and KEGG pathway database. The network between compounds, targets, and pathways was generated via Cytoscape ver. 3.6.1. Docking was performed by AutoDock vina using PyRx0.8v. YYEO group showed increased BW compared to alcohol group and also reversed the increased serum AST, ALT, TP, TC, TG, and TB biomarkers and also increased the level of antioxidant enzymes compared to alcohol induced group. YYEO 400 mg/kg exhibited normal liver weight and histology compared to alcohol. Enrichment and network analysis identified YYEO 63 compounds as beneficial modulators of protein molecules associated with hepatotoxicity via modulating Toll-like receptor, Adipocytokine, TNF, Sphingolipid, FoxO, AMPK, Relaxin, MAPK, NF-kappa B, HIF-1, Fc epsilon RI, IL-17, VEGF, T cell receptor, NOD-like receptor, mTOR, PI3K- Akt signaling pathway, etc. Canangaterpene 1 was identified as a potent inhibitor of aldose reductase. Graphical abstract
      PubDate: 2022-03-04
      DOI: 10.1007/s13596-022-00630-w
       
  • Lead phytomolecules for gastroprotective drug development

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      Abstract: Abstract Peptic ulcer disease represents an important public health problem worldwide. Such disease may occur due to improper balance in the aggressive as well as in the defensive mechanisms. Although proton pump inhibitors reduces the production of stomach acid and help in decreasing mortality and morbidity rates due to gastic problems. Products obtained from natural sources also represent therapeutic alternatives for the treatment of gastric problems. Gastroprotective effect of herbs is endorsed to its bioactive phytomolecules present in it. In view of this, study was designed to survey the literature of secondary metabolite, plant source as well as signaling pathways. For literature survey of secondary metabolites, plant sources and signaling pathways various electronis databases were searched and data were compiled.The study of this literature survey revealed that secondary metabolites from plant origin have the potential to become the active gastroprotective agent. Consequently, phytomolecules are proved to be ideal one with much effectiveness property and possessing less toxicity associated with therapeutic potential for preventing and curing the gastrointestinal disorders. It can, therefore, be identified and recommended as a novel lead for drug development process to design gastroprotective drug.
      PubDate: 2022-03-02
      DOI: 10.1007/s13596-022-00633-7
       
  • Carica papaya: comprehensive overview of the nutritional values,
           phytochemicals and pharmacological activities

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      Abstract: Abstract Carica papaya is a perennial large herbaceous plant known for diverse biological activities. Different parts of this plant such as seeds, leaves, fruits, peels, roots, and stems have been previously reported to possess nutritional and medicinal values. This plant possesses a nutritional value that is rich in vitamins and natural minerals but low in calories. Moreover, every part of this plant had been used in treating different type of diseases which include wound dressing, antibacterial, anthelminthic effects, traditionally used to control birth, and several other activities. These were born out of the in vitro and in vivo studies conducted on the extracts from parts of C. papaya. Furthermore, the occurrences of different kinds of phytochemicals in the extracts might have been responsible for its diverse pharmacological properties. Thus, this article comprehensively outlines and discusses nutritional values, phytochemistry and pharmacological activities of C. papaya.
      PubDate: 2022-03-01
       
  • Chemical analysis and in silico anticancer and anti-inflammatory
           potentials of bioactive compounds from Moringaoleifera seed oil

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      Abstract: Abstract Breast and prostate cancers are the first and second most leading cause of mortality and morbidity in women and men respectively. Today lots of drugs are available for treatment but their adverse effect, potentially distressing toxicity only add to patient discomfort and limits their use. Identification of novel sources for developing new anticancer drugs with little or no side effect is imperative. In vitro antioxidant activities crude and degummed Moringa oleifera seed oil were determined using standard methods. Fatty acid and phytosterols were identified through GC–MS. Molecular docking studies was performed to investigate the binding interactions between natural compounds and five various anti-cancer drug targets. Also the proteins were docked to standard inhibitors and the binding affinities were determined. Molecular interactions between proteins and ligands were viewed with discovery studio 4.5. The binding energy was compared with the known inflammatory, breast and prostate cancer inhibitory drugs namely: exemestane, talazoparib, pictilisib, thalidomide and Z-IETD-fmk. Crude oil exhibited more potent antioxidant activities than the degummed oil. Minerals and vitamins were reduced after degumming. Phytosterol showed that β-Sitosterol is the predominant phytosterol which was higher in the degummed oil. β-Sitosterol displayed the best inhibitory activity against the standard inhibitors except Z-IETD-fmk; while oleic acid exhibited poor binding energy when compared with the standard inhibitors except thalidomide. β-Sitosterol played a promising role against breast and prostate cancer protein targets and hence can act as a template for further studies as cancer drug candidates.
      PubDate: 2022-03-01
       
  • The modulatory effect of Hydrocotyle sibthorpioides in attenuating the
           aluminium chloride induced neurotoxicity in rat brain

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      Abstract: Hydrocotyle sibthorpioides Lam. (Family: Araliaceae) is used widely in the preparation of food in different cuisines of the world. The study was designed to explore the protective effect of different standardised extracts of H. sibthorpioides on the AlCl3 induced neurotoxicity in Alzheimeric rats. When AlCl3 at a dose of 100 mg/kg body weight was administered i.p. for 60 days showed a significant increase in aluminium (Al) level, acetylcholinesterase (AChE) level and protein expressions of amyloid precursor proteins, β and γ secretase, and β-amyloid (Aβ1–42) in the cortex and hippocampus comparing to the control. Moreover, there was a significant reduction in locomotor activity, muscle coordination and cognition and memory. On the other hand, animals treated with chloroform and methanolic extracts of H. sibthorpiodes given at 200 and 100 mg/kg body weight orally with AlCl3 altered the behavioural impairment caused by Al and Al concentration, activity of AChE, synthesis molecules of Aβ generation. The report of histological studies in hippocampus and cortex supported the neuroprotective role of chloroform and a methanolic extract of H. sibthorpioides, which conserved a normal histoarchitecture pattern of cortex and hippocampus. Finally, it can be concluded that chloroform and methanolic extract of H sibthorpioides can alter memory loss induced by aluminum toxicity by enhancing AChE activity and by its involvement in amyloidogenic pathway. Graphic abstract
      PubDate: 2022-03-01
       
  • In vitro and in silico inhibition of α-amylase, α-glucosidase, and
           aldose reductase by the leaf and callus extracts of Vernonia anthelmintica
           (L.) Willd.

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      Abstract: Abstract In the present study, the leaf and callus extracts of Vernonia anthelmintica prepared in three different solvents (methanol, ethyl acetate, and chloroform) were assessed for inhibition of α-amylase (EC 3.2.1.1), α-glucosidase (EC 3.2.1.20) and aldose reductase (EC 1.1.1.21). Both the leaf and callus extracts showed remarkable inhibition against these enzymes. Alpha-amylase inhibition was the highest in ethyl acetate extract of calli and methanolic extract of leaves. Ethyl acetate extract of both leaf and calli showed significant alpha-glucosidase and aldose reductase inhibition. HR-LCMS analysis of ethyl acetate fraction of leaf extract showed the presence of the flavonol rhamnetin. Also, the HPLC chromatogram revealed the presence of rhamnetin in callus extract. Further, in silico docking studies of rhamnetin was done against the above-mentioned enzymes. The in silico analysis revealed that compound rhamnetin showed good enzyme inhibition.
      PubDate: 2022-03-01
       
  • Chemical composition, in vitro antioxidant, and enzymes inhibitory
           potential of three medicinally important plants from Nepal (Lepisorus
           mehrae, Pleurospermum benthamii, and Roscoea auriculata)

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      Abstract: The aim of this study was to examine antioxidant properties, major enzyme inhibition activities, and targeted metabolites profiling of Lepisorus mehrae, Pleurospermum benthamii, and Roscoea auriculata in different solvent extracts. This is the first report on metabolites profiling and biochemical activities of these plant species. Our results revealed that L. mehrae, P. benthamii, and R. auriculata are rich source of bioactive secondary metabolites and have good antioxidant potential. The methanol extract of L. mehrae, P. benthamii, and R. auriculata showed substantial inhibitory potential towards elastase, whereas water extract of L. mehrae and R. auriculata were more strong inhibitors of tyrosinase. Among the three plants, P. benthamii showed noteworthy inhibition on α-amylase, α-glucosidase, lipase, tyrosinase, elastase, and cholinesterases enzymes. High resolution mass spectrometry analysis revealed the presence of metabolites such as Protocatechuic acid, Gallic acid, 7,8,3′,4′-tetrahydroxyflavanone, Rhamnocitrin, Quercetin, Hyperoside, Quercetin-7-glucoside, Rutin, Rhamnetin, Aromadendrin, Camphor, and Hexanoic acid in L. mehrae. Moreover, Catechin and Fisetin were present in P. benthamii and Kaempferide, 7,8,3′,4′-Tetrahydroxyflavone, 5,7-Dihydroxy-2,3-dihydroflavonol 3-acetate, and Aromadendrin were present in R. auriculata. The results presented here provide enough scientific evidence that these plant species have diverse biochemical potential and can be examined further for their potential use in modern pharmaceuticals, cosmetics, and nutraceuticals. Graphic abstract
      PubDate: 2022-03-01
       
  • Essential oils and their pharmacotherapeutics applications in human
           diseases

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      Abstract: Abstract Essential oils (EOs) are natural products obtained from different parts of a plant, such as flower, leaves, stems, fruits, seeds, roots, barks, or resin. It represents an important part of traditional pharmacopeia practices in healing of human ailments. It is used as raw materials in cosmetics, spices, foods, perfumes, and in treatment of several health disorders. There are several methods for extracting EOs from plants. They are the methods like hydro-distillation, steam distillation, hydro diffusion and cold pressing to name a few. The use of EOs as antimicrobial and pharmaceutical agents for curing various diseases has gained a considerable attraction of researchers in recent times. The complex mixture of EOs and their constituents have been reported to inhibit human pathogens, insects, and another harmful organism. The current review focusses on the chemical bioactive components of EOs, methods of extraction, chemical constituent, different plants as source of extraction and its application towards the treatment of various diseases in our day to day life, in vivo validation of essential oil, nanoformulation of essential oils.
      PubDate: 2022-03-01
       
  • Experimental validation and network pharmacology evaluation to decipher
           the mechanism of action of Erythrina variegata L. bark against
           scopolamine-induced memory impairment in rats

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      Abstract: This paper aimed to elucidate the effect of Erythrina variegata L. bark on scopolamine-induced memory impairment in rats and to decipher the molecular mechanism of phytoconstituents via the utilization of gene set enrichment analysis, network pharmacology coupled with in silico docking study. First, three models i.e. Morris Water Maze (MWM), Elevated Plus Maze (EPM), and Passive Avoidance Paradigm (PA) were utilized to elucidate the memory function. Second, the level of biomarkers i.e. acetylcholinesterase enzyme, reduced glutathione, and lipid peroxidation level were measured in brain tissues. Third, the key bioactive phytoconstituents targeting potential protein targets and pathways were identified through gene set enrichment analysis and network pharmacology. Lastly, the interaction between bioactive phytoconstituents with their respective targets was confirmed by molecular docking analysis. The MWM, EPM, and PA activity showed, scopolamine administration increased Escape Latency Time (ELT), Transfer Latency (TL), and Step Through Latency (STL) respectively on day 0th, 7th, 14th, and 21st, whereas treatment with E. variegata extract significantly reverse the ELT, TL and STL activity. The decreased level of Acetylcholinesterase (AChE) and MDA level in treated animals reflected the enhanced memory and was found to be comparable withclinically proven drug i.e. donepezil. Sixty compounds were identified in EV bark, among which twenty-two compounds are predicted to modulate potential targets involved in AD and considered potentially bioactive. Further, the docking study revealed, Alpinumisoflavone, Auriculatin, Osajin, and Scandenone to have the highest binding affinity with Tau protein, Whereas Donepezil and Glucoerysodine with acetylcholinesterase enzyme. Graphic abstract
      PubDate: 2022-03-01
       
  • Analysis of the variations in the marker compound of Glycyrrhiza glabra L.
           root with reference to age of the drug, storage conditions and
           pharmacological efficacy

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      Abstract: Abstract Phyto-constituents and their efficacy vary with the age of the plant material and their affliction with environmental and storage conditions. Present study was conducted to evaluate the time dependent variation in physicochemical characters, glycyrrhizin content, microbial load and anti-inflammatory activity of Glycyrrhiza glabra L. root (GGR). Fresh GGR was dried and divided into three samples and stored as: sample A below 4 °C, sample B at room temperature and sample C at 40 ± 2 °C with relative humidity 75 ± 5% for six months. Afterwards, each sample was extracted in 50% alcohol and evaluated for physicochemical characters, glycyrrhizin content, microbial contamination and anti-inflammatory activity in histamine-induced inflammation in Wistar rats. Physicochemical characteristics exhibits less than 25% variation and qualitative analysis for plant metabolites exhibited similarity in all three samples. Glycyrrhizin was found more in sample C (5.07%) in comparison to sample B (4.52%) and A (4.72%) with variation less than 15%. As per the Ayurvedic Pharmacopeia of India these variations in physicochemical parameters and glycyrrhizin content are insignificant. Sample A revealed total microbial count more than B and C. Accelerated stability data extrapolation of sample C suggests that shelf life of GGR is 2 years. Inflammation was significantly reduced by sample C followed by A and B in comparison to the control with residual paw volume of 0.9%, 3.22%, 20.4% and 29.7% respectively at 163 mg/kg BW dose. From the present study it can be concluded that up to two years age dependent variations in GGR is insignificant but its anti-inflammatory effect are glycyrrhizin dependent.
      PubDate: 2022-03-01
       
  • Acacia pennata L. leaves: chemical profiling and impact on DNA damage,
           alteration of genotoxicity—related genes expression and ROS generation
           in hepatic tissues of acetaminophen treated male rats

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      Abstract: Abstract From the phenolic profile of Acacia pennata L. leaves hydromethanolic extract, nine flavonoids were tentatively characterized (liquid chromatography-electrospray ionization mass spectrometry), of which Kaempferol 3,7-di-O-hexoside, Apigenin 6,8-di-C-hexoside, Luteolin-6-C-pentoside-8-C-hexoside, Apigenin-6-C-hexoside-8-C-pentoside and Apigenin-6-C-pentoside-8-C-hexoside were detected for the first time from the plant. Three doses of the plant extract (12.5, 25 and 50 mg/kg bw/d, four weeks treatment) were used to assess its protective effect against acetominophen induced genotoxicity in hepatic cells of male rats (2 g/kg bw twice per week). A. pennata extract and Acetominophen treated animal groups attenuated DNA damage rates (Comet assay) by 5.6, 6.2 and 6.4% for the three doses, respectively, compared with the acetaminophen treated and untreated groups by 21.2% and 5.8%, respectively. It also decreased DNA fragmentation, significantly down-regulate the expression of p53 tumour suppressor gene and mdr1b multidrug resistance gene [real-time PCR (qPCR)] and ROS generation rates induced by Acetaminophen by 715.4, 453.8 and 376.9% in rats in a dose dependant effect. The results highlighted the DNA protection potential of A. pennata phytoconstituents from drug abuse harmful effects.
      PubDate: 2022-03-01
       
  • Evaluation of hair growth properties of Topical Kombucha tea extracts

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      Abstract: Abstract Consuming functional foods and drinks such as kombucha tea is believed to give many beneficial effects for promoting immunity and preventing cancer. The fermented tea with sugar and symbiotic culture of yeast and bacteria is also useful in the topical application for hair re-growth. This study aims to investigate hair re-growth properties of kombucha black tea and chamomile with and without methylsulfonylmethane. Treatments were applied topically to denuded Balb/c mice and observed for hair growth initiation time, density and length in 15 and 30 days in addition to microbiological identification of the main yeast and bacteria. Results showed significantly better hair density and length in groups treated with kombucha black tea with and without MSM, followed by kombucha chamomile tea with and without MSM respectively. In addition, it has been found that MSM promotes hair growth significantly when combined with kombucha ferments. Microbiological analysis indicated the presence of Zygosaccharomyces bailii and Acetobacter genus in the tea broth. Black tea kombucha with MSM can be used as a natural alternative therapy for hair fall and a cost-effective treatment with fewer side effects compared to the synthetic drugs.
      PubDate: 2022-03-01
       
 
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