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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted by number of followers
Nature Reviews Drug Discovery     Full-text available via subscription   (Followers: 332)
International Journal of Drug Policy     Hybrid Journal   (Followers: 254)
Journal of Clinical Oncology     Hybrid Journal   (Followers: 242)
Journal of Medicinal Chemistry     Hybrid Journal   (Followers: 157)
Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 155)
Drugs     Full-text available via subscription   (Followers: 146)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 98)
Pharmaceutical Research     Hybrid Journal   (Followers: 94)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 86)
Drug Safety     Full-text available via subscription   (Followers: 83)
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 56)
Biomaterials     Hybrid Journal   (Followers: 54)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 44)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 42)
Journal of Controlled Release     Hybrid Journal   (Followers: 38)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 38)
International Journal of Pharmaceutics     Hybrid Journal   (Followers: 37)
Clinical Therapeutics     Hybrid Journal   (Followers: 34)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 34)
Pharmacoepidemiology and Drug Safety     Hybrid Journal   (Followers: 33)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 32)
Journal of Pharmacy and Pharmacology     Full-text available via subscription   (Followers: 31)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 29)
PharmacoEconomics     Full-text available via subscription   (Followers: 27)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 27)
AAPS Journal     Hybrid Journal   (Followers: 26)
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 25)
Journal of Clinical Psychopharmacology     Hybrid Journal   (Followers: 24)
International Journal of Pharmacy Practice     Full-text available via subscription   (Followers: 24)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 24)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 22)
Journal of Pharmacokinetics and Pharmacodynamics     Hybrid Journal   (Followers: 22)
Journal of Pain & Palliative Care Pharmacotherapy     Hybrid Journal   (Followers: 21)
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 20)
Journal of Applied Toxicology     Hybrid Journal   (Followers: 19)
Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 19)
Pharmaceutical Development and Technology     Hybrid Journal   (Followers: 19)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 19)
Clinical Trials     Hybrid Journal   (Followers: 18)
Toxicology     Hybrid Journal   (Followers: 18)
Journal of Pharmaceutical and Biomedical Analysis     Hybrid Journal   (Followers: 18)
Clinical Toxicology     Hybrid Journal   (Followers: 18)
International Journal of Toxicology     Hybrid Journal   (Followers: 17)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Journal of Clinical Pharmacy and Therapeutics     Hybrid Journal   (Followers: 16)
Journal of Natural Products     Hybrid Journal   (Followers: 16)
Pharmaceutical Statistics     Hybrid Journal   (Followers: 15)
Toxicology Letters     Hybrid Journal   (Followers: 15)
Journal of Pharmacy Practice     Hybrid Journal   (Followers: 15)
Psychopharmacology     Hybrid Journal   (Followers: 15)
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 14)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 14)
Current Medicinal Chemistry     Hybrid Journal   (Followers: 13)
American Journal of Therapeutics     Hybrid Journal   (Followers: 13)
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 13)
Journal of the American Pharmacists Association     Full-text available via subscription   (Followers: 13)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 12)
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 12)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 12)
Journal of Oncology Pharmacy Practice     Hybrid Journal   (Followers: 12)
Journal of Psychopharmacology     Hybrid Journal   (Followers: 11)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 11)
Toxicology in Vitro     Hybrid Journal   (Followers: 11)
Drug Development Research     Hybrid Journal   (Followers: 11)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 11)
Seminars in Oncology Nursing     Full-text available via subscription   (Followers: 10)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Journal of Separation Science     Hybrid Journal   (Followers: 10)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 10)
Journal of Medical Marketing     Hybrid Journal   (Followers: 10)
Drugs & Aging     Full-text available via subscription   (Followers: 10)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 9)
Food Additives & Contaminants Part A     Hybrid Journal   (Followers: 9)
Journal of Pharmacology and Experimental Therapeutics     Hybrid Journal   (Followers: 9)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 9)
Medicinal Chemistry     Hybrid Journal   (Followers: 9)
Biometrical Journal     Hybrid Journal   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Prescriber     Hybrid Journal   (Followers: 9)
ChemMedChem     Hybrid Journal   (Followers: 9)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 9)
European Journal of Pharmacology     Hybrid Journal   (Followers: 8)
Inhalation Toxicology     Hybrid Journal   (Followers: 8)
Antiviral Research     Hybrid Journal   (Followers: 8)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 8)
Progress in Neuro-Psychopharmacology and Biological Psychiatry     Hybrid Journal   (Followers: 8)
Human & Experimental Toxicology     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 8)
BioDrugs     Full-text available via subscription   (Followers: 8)
Frontiers in Drug Design & Discovery     Hybrid Journal   (Followers: 8)
Expert Review of Pharmacoeconomics & Outcomes Research     Full-text available via subscription   (Followers: 8)
Experimental and Clinical Psychopharmacology     Full-text available via subscription   (Followers: 7)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 7)
Journal of Pharmacological and Toxicological Methods     Hybrid Journal   (Followers: 7)
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 7)
Scandinavian Journal of Clinical and Laboratory Investigation     Hybrid Journal   (Followers: 7)
Epilepsy Research     Hybrid Journal   (Followers: 7)
Clinical Drug Investigation     Full-text available via subscription   (Followers: 7)
Journal of Veterinary Pharmacology and Therapeutics     Hybrid Journal   (Followers: 6)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 6)
Journal of Cardiovascular Pharmacology     Hybrid Journal   (Followers: 6)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 6)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 6)
Current Therapeutic Research     Open Access   (Followers: 6)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 6)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Expert Review of Anti-infective Therapy     Full-text available via subscription   (Followers: 5)
Neuropharmacology     Hybrid Journal   (Followers: 5)
Current Drug Metabolism     Hybrid Journal   (Followers: 5)
Fitoterapia     Hybrid Journal   (Followers: 5)
Expert Review of Molecular Diagnostics     Full-text available via subscription   (Followers: 5)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Toxicon     Hybrid Journal   (Followers: 5)
Medicinal Research Reviews     Hybrid Journal   (Followers: 5)
Investigational New Drugs     Hybrid Journal   (Followers: 5)
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Reviews of Physiology, Biochemistry and Pharmacology     Hybrid Journal   (Followers: 4)
Planta Medica     Hybrid Journal   (Followers: 4)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 4)
Pharmaceutical Medicine     Full-text available via subscription   (Followers: 4)
Journal of Child and Adolescent Psychopharmacology     Hybrid Journal   (Followers: 4)
CNS Drug Reviews     Open Access   (Followers: 4)
Inpharma Weekly     Full-text available via subscription   (Followers: 4)
Journal of Labelled Compounds and Radiopharmaceuticals     Hybrid Journal   (Followers: 4)
Immunopharmacology and Immunotoxicology     Hybrid Journal   (Followers: 4)
International Journal of Pharmaceutical and Healthcare Marketing     Hybrid Journal   (Followers: 4)
Inflammation Research     Hybrid Journal   (Followers: 4)
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
International Journal of Neuropsychopharmacology     Open Access   (Followers: 3)
Pharmacology & Therapeutics     Hybrid Journal   (Followers: 3)
Physiology International     Full-text available via subscription   (Followers: 3)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Pharmacopsychiatry     Hybrid Journal   (Followers: 3)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Therapeutic Drug Monitoring     Hybrid Journal   (Followers: 3)
Current Drug Therapy     Hybrid Journal   (Followers: 3)
Research in Social and Administrative Pharmacy     Hybrid Journal   (Followers: 3)
PharmacoEconomics & Outcomes News     Full-text available via subscription   (Followers: 3)
Journal of Aerosol Medicine and Pulmonary Drug Delivery     Hybrid Journal   (Followers: 3)
Journal of Ethnopharmacology     Hybrid Journal   (Followers: 3)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Journal of Pain Management & Medicine     Open Access   (Followers: 3)
Journal of Infection and Chemotherapy     Hybrid Journal   (Followers: 3)
Journal of Cardiovascular Pharmacology and Therapeutics     Hybrid Journal   (Followers: 3)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 3)
Microbial Drug Resistance     Hybrid Journal   (Followers: 3)
Frontiers in Medicinal Chemistry     Hybrid Journal   (Followers: 3)
Human Psychopharmacology Clinical and Experimental     Hybrid Journal   (Followers: 3)
BMC Pharmacology     Open Access   (Followers: 2)
The Brown University Psychopharmacology Update     Hybrid Journal   (Followers: 2)
International Clinical Psychopharmacology     Hybrid Journal   (Followers: 2)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 2)
Journal of Drug Targeting     Hybrid Journal   (Followers: 2)
Inflammopharmacology     Hybrid Journal   (Followers: 2)
Journal of Inflammation     Open Access   (Followers: 2)
Fundamental & Clinical Pharmacology     Hybrid Journal   (Followers: 2)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Vascular Pharmacology     Hybrid Journal   (Followers: 2)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Drugs in R & D     Full-text available via subscription   (Followers: 2)
International Immunopharmacology     Hybrid Journal   (Followers: 2)
Pharmacology Biochemistry and Behavior     Hybrid Journal   (Followers: 2)
Letters in Drug Design & Discovery     Hybrid Journal   (Followers: 2)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Pharmacological Reviews     Hybrid Journal   (Followers: 2)
Molecular Pharmacology     Hybrid Journal   (Followers: 2)
Journal of Microencapsulation: Microcapsules, Liposomes, Nanoparticles, Microcells, Microspheres     Hybrid Journal   (Followers: 2)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Particulate Science and Technology: An International Journal     Hybrid Journal   (Followers: 1)
Pharmacological Research     Hybrid Journal   (Followers: 1)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Journal of Neuroimmune Pharmacology     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Pharmacogenetics and Genomics     Hybrid Journal   (Followers: 1)
Journal of Texture Studies     Hybrid Journal   (Followers: 1)
Pharmaceutical Biology     Open Access  
Journal of Liposome Research     Hybrid Journal  
Toxin Reviews     Hybrid Journal  
Kaohsiung Journal of Medical Sciences     Open Access  
Redox Report     Open Access  
Pharmacology     Full-text available via subscription  
Pharmaceutical Chemistry Journal     Hybrid Journal  
NeuroMolecular Medicine     Hybrid Journal  
Journal of Ocular Pharmacology and Therapeutics     Hybrid Journal  
Harm Reduction Journal     Open Access  
Current Nanoscience     Hybrid Journal  
Infectious Disorders - Drug Targets     Hybrid Journal  
Current Bioactive Compounds     Hybrid Journal  
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Autonomic & Autacoid Pharmacology     Hybrid Journal  

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Oriental Pharmacy and Experimental Medicine
Journal Prestige (SJR): 0.169
Number of Followers: 2  
 
  Partially Free Journal Partially Free Journal
ISSN (Print) 1598-2386 - ISSN (Online) 2211-1069
Published by Springer-Verlag Homepage  [2467 journals]
  • Aqueous extract of Moringa oleifera Lam. induced mitodepression and
           chromosomal aberration in Allium cepa, and reproductive genotoxicity in
           male mice

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      Abstract: Abstract Moringa oleifera is a multipurpose plant with nutritional and medicinal value. Despite its widely acclaimed therapeutic benefits in traditional medicine, there are reports on its toxicity in living cells. Information is however, limited on toxic effect of the plant on the genetic component and male reproductive cells. We evaluated genotoxicity of aqueous extract of the leaves of M. oleifera using the Allium cepa chromosome aberration (CA) and mouse sperm morphology assays. Roots of onion bulbs were exposed to 0.5–20% of the extract for analysis of root growth inhibition, mitotic index (MI) and CA. Swiss male mice orally exposed to the aqueous extract (50–800 mg/kg) for 35 consecutive days were analysed for body and testes weight, testicular histology and sperm morphology. There was a significant (p < 0.05) root growth inhibition, decrease in MI and induction of CA compared to the negative control bulbs. The extract did not cause adverse effect on body and testes weight, but maturation arrest, atrophy and germ cell sloughing and degeneration were observed in testicular sections of exposed mice. A significant increase in sperm morphology was observed in exposed mice relative to the control group. Aqueous extract of M. oleifera was cytotoxic, mitodepressive and genotoxic in A. cepa. It induced DNA damage in the sperm head and interfered with spermatogenesis. This suggests potentials of M. oleifera to modulate somatic cell cycle and impact male fertility.
      PubDate: 2022-12-01
       
  • Ameliorative effects of Guilandina bonduc L. aqueous seed extract on
           letrozole induced polycystic ovary syndrome in female wistar albino rats

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      Abstract: Abstract The current study aims to identify the phytochemical constituents of Guilandina bonduc L. aqueous seed extract to evaluate their antioxidant potential through in vitro and in vivo toxicity models in female wistar albino rats. Phytochemical screening and in vitro antioxidant activities of G. bonduc aqueous seed extract (GBASE), were evaluated using 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH) and hydroxyl radical along with the estimation of total phenolic and flavonoid contents. Three different doses (100, 200 and 300 mg/kg) were used for the proposed study to evaluate the efficacy against Letrozole induced PCOS in rats. Renal toxicity and hepatotoxicity were evaluated by quantifying the serum levels of Kidney Function Test (KFT) and Liver Function Test (LFT). Histopathologic changes of kidney and liver were also evaluated. In vitro studies revealed that G. bonduc seed extracts strongly scavenging the DPPH with an IC50 value of 276.95 μg/ml and hydroxyl scavenging radical with an IC50 value of 296.34 μg/ml. Our phytochemical evaluation reveals the presence of phenolic compounds (2.834 ± 0.09 mg of gallic acid equivalent/g dried extract) and flavonoids (0.905 ± 0.01 mg of catechol equivalents/g dried extract) content. In vivo activity was evaluated in rats as an PCOS model, when compared to control and vehicle group, a normal arrangement of the hepatocyte sheath and central vein was observed. The letrozole induced by PCOS groups also exhibited no remarkable changes in hepatic histology but a minor irregularity in hepatocyte arrangement was observed. In the treatment group, the histopathological evaluation of the kidneys showed a prevalent control-like morphology with a sufficient mobile structure and a standard atrophy free glomerulus. Moreover, the treated animals showed significant changes in their liver and kidney weights. The biochemical evaluation shows elevated levels of serum AST and it indicates harm to the liver due to necrosis, inflammation, or bruising, indicating ill health. The aqueous seed extracts of 200 mg/kg exhibited a significant response compare favorably to that of the standard drug treated group (PCOS + Pioglitazone) which also had substantially reduced KFT and LFT levels in their serum when compared to the PCOS induced group. Herbal medications strengthen the immune system and help regulate the menstrual cycle. The results suggest that G. bonduc L. could be considered as an important candidate for its possible role in the treatment of PCOS and for the future drug discoveries.
      PubDate: 2022-12-01
       
  • Diuretic efficacy and prophylactic effects of hydroethanolic extract from
           Musa balbisiana fruits against urolithiasis

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      Abstract: Abstract The use of herbs as prophylactic and prevent recurrence of urolithiasis was counseled. Musa balbisiana fruits have long been used folk in the treatment of urinary stones. However, there is no clear scientific evidence. This study was designed to investigate the diuretic and prophylactic effects of M. balbisiana fruit extract in ethylene glycol-induced urolithiasis in rats. In this study, crude extracts were extracted by maceration, hot extraction, and decoction methods. The extracts were examined in vitro biological activities of anti-urolithiatic, anti-inflammatory, antibacterial, and antioxidant properties. For in vivo study, the experimental groups of rats were given the extract for 7-day to evaluate the diuretic potential. In prophylactic activity against urolithiasis, rats were given the extract for 28-day on ethylene glycol-induced urolithiasis in male Wistar rats. The results showed that all extracts of M. balbisiana fruits exhibited in vitro anti-urolithiatic, anti-inflammatory, antibacterial, and antioxidant activities with the hydroethanolic extract by hot extraction presented the highest activities. The hydroethanolic extract at the doses of 0.8 and 1.6 g/kg had diuretic effect after 7-day of treatment. The extract at these two doses had significantly prophylactic activity restored the parameters in urine and serum to near-normal level. The histopathological examinations revealed that calcium oxalate crystal deposits in the renal tubules and congestion and dilation of the renal tubules were significantly reverted after the extract treatment for 28-day. Taken together, the hydroethanolic extract of M. balbisiana fruits had diuretic effect and reduced the growth of urinary stones showing its effect as an antiurolithiatic support agent.
      PubDate: 2022-12-01
       
  • In vitro and in silico evaluation of some plant extracts and
           phytocompounds against multidrug-resistant Gram-negative bacteria

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      Abstract: Abstract The spread of multidrug-resistant Gram-negative (MDR) bacteria is a global public health problem, as infections caused by MDR Gram-negative bacteria are difficult to treat. New antibiotic agents need to be developed to overcome this problem, and phytochemicals show promise at this point. In this study, methanol extracts were prepared from cinnamon, thyme, nettle, white tea, rosehip, and antibacterial activity of the methanol extracts was studied against two MDR Gram-Negative bacteria (K. pneumoniae and A. baumannii) by broth microdilution method. The MICs of methanol extracts of cinnamon, rosehip, thyme, white tea for A. baumannii were found as 0.015125 g/ml, 0.07825 g/ml, 0.030625 g/ml, 0.00796875 g/ml, respectively. It was found that only cinnamon methanol extract had antibacterial activity in the used extract concentrations against K. pneumoniae and the MIC value was 0.0605 g/ml. The effects of plant methanol extract with antibacterial activity and imipenem combinations were studied in vitro using the checkerboard method. The FIC Indexes were obtained from the checkerboard results and it was observed that the combination of methanol extract and imipenem showed an antagonistic or additive/indifferent effect but not a synergistic effect. We evaluated the binding affinity of epigallocatechin 3-gallate, quercetin, cinnamaldehyde, carvacrol, and thymol phytocompounds using in silico methods, which are well known as a phytocompounds in white tea, cinnamon, thyme, nettle, and rosehip and have antibacterial activities. The results suggested that these phytocompounds should be supported with in vivo and in vitro experiments to investigate their potential for being inhibitor candidates.
      PubDate: 2022-12-01
       
  • Antimicrobial evaluation and molecular docking studies of Swertiamarin and
           Quercetin targeting dihydropteroate synthase enzyme

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      Abstract: Present study was aimed to evaluate synergistic antimicrobial activity of iridoid (Swertiamarin) and flavonoid glycoside (Quercetin). Swertiamarin (Sw) was isolated from methanol extract of Enicostemma axillare and quercetin (Qu) was purchased. The antimicrobial activity of Sw, Qu and combination of swertiamarin and quercetin (SQC) was evaluated against Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Methicillin resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans using turbidimetric method. Molecular docking study of Sw and Qu was done on the target site of dihydropteroate synthase (DHPS) of protein data bank (PDB) ID: 3TYC (Dihydropteroate Synthase in complex with DHP +). Sw and Qu exhibited good antimicrobial activity in all the tested microorganisms at lower concentration (2.5 µg/ml). The SQC displayed significant antimicrobial activity and found high percentage of inhibition and comparable to standard ciprofloxacin. In molecular docking study, Sw and Qu have found good binding energy and interaction energy with the selected target site of DHPS of 3TYC. Graphical abstract
      PubDate: 2022-12-01
       
  • Phytochemicals from Nigerian medicinal plants modulate
           therapeutically-relevant diabetes targets: insight from computational
           direction

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      Abstract: Abstract Traditional medicines have played critical roles in the treatment of diabetes in Nigeria. Since plants extracts contain many phytochemical compounds, it is quite challenging to experimentally determine the exact pharmacological agent responsible for their antidiabetic activity from the abundant constituents. In this study, the antidiabetic potentials of compounds identified from Nigerian plants was explored using computational technique. Fifty chemical compounds commonly found in Nigerian medicinal plants were docked with diabetes prime targets adiponectin, α-amylase, α-glucosidase, dipeptidyl peptidase-iv, glycogen synthase kinase-3β, peroxisome proliferator-activated receptor-γ and glucose transporter-1 using autodock vina software. From the analysis, rutin, 1, 5-Dicaffeoylquinic acid, vitexin, chlorogenic acid, taxifolin, luteolin and alstonine had better docking score than the standard drug for each target. The seven top-scoring compounds were stable with the targets after calculating their binding free energy. DFT calculations (HOMO/LUMO and global descriptive parameters) was performed to determine the compounds reactivity, and it shows that alstonine, Dicaffeoylquinic acid and chlorogenic acid are the most chemical reactive ligands. The AMET filtering of the compounds through pain alert, RO5, carcinogenicity and oral availability showed that alstonine and vitexin exhibited better profile among the rest. Finally, the intrinsic biological activity of the ligands by webserver identified the compounds as potential antidiabetic compounds, with more potency to act as aldose reductase inhibitor. Although this study identified alstonine and vitexin as the most suitable ligands against the understudied diabetes implicated proteins, all the 7-top scoring compounds possess promising features which may be useful to develop drug targeting multiple therapeutically-relevant proteins of diabetes.
      PubDate: 2022-12-01
       
  • Microwave-assisted extraction of Clausena anisata leaves and Vernonia
           cinerea whole plants to maximize nitrate content: optimization approach,
           antioxidant activity, and cytotoxicity

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      Abstract: Nitrate-rich plants—Clausena anisata leaves and Vernonia cinerea whole plants—are used as smoking cessation aids in Thailand. This work sought to optimize the extraction condition of nitrate from the two plants using microwave-assisted extraction. The Box-Behnken design was applied in this work. Antioxidant activity and in vitro cytotoxicity tests were also evaluated. Three factors including microwave power, duration time, and irradiation cycle, were varied from 300 to 600 W, 10 to 30 s, and 1 to 3 cycles, respectively. Two responses including extraction yield and nitrate content were monitored. Results demonstrated that the low microwave power (300 W) with short duration time (10 s), and low irradiation cycle (one cycle) gave the highest nitrate content. The optimum condition provided extraction yield of 26.0 ± 1.1% and nitrate content of 1.31 ± 0.03% for C. anisata leaves, and extraction yield of 15.9 ± 0.2% and nitrate content of 1.32 ± 0.01% for V. cinerea whole plants. Furthermore, their crude extracts exhibited good antioxidant activity and safety profile. In summary, microwave-assisted extraction was an alternative modern technique for the extraction of nitrate from C. anisata leaves and V. cinerea whole plants. Recently, only V. cinerea was officially included in the National List of Essential Medicines. This work could be used to support the potential of C. anisata leaves as a smoking cessation aid like V. cinerea. Graphical abstract
      PubDate: 2022-12-01
       
  • Evaluation of the antiproliferative effect of β-sitosterol isolated from
           Combretum platypetalum Welw. ex M.A. Lawson (Combretaceae) on Jurkat-T
           cells and protection by glutathione

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      Abstract: Abstract Combretum species are distributed widely in Southern Africa and are known for their medicinal properties. The species have potential as sources of anticancer agents. Combrestanin-A4 isolated from Combretum caffrum is one of the pure compounds now under clinical trials. The aim of this study was to fractionate and isolate plant phytoconstituents of C. platypetalum and determine their antiproliferative effects on a human leukemic cancer cell line, Jurkat-T cells. Dried powdered leaf plant samples were extracted serially with hexane, DCM, acetone, ethyl acetate, ethanol, methanol, and water. The total combined extracts were run on a silica gel column using a mobile phase of increasing polarity. β-Sitosterol was isolated from pool 94–98 of the fractions and identified by 1H-NMR and 13C-NMR and its molecular formula confirmed by mass spectrometry. The effects of β-sitosterol on proliferation of cells, effect of combining β-sitosterol and glutathione, effect of combining β-sitosterol and camptothecin and effect of β-sitosterol on glutathione S-transferase activity were determined. β-sitosterol showed dose-dependent antiproliferative effects against Jurkat-T cells and these effects were shown to be irreversible. Reduced glutathione protected the cells from the effects of β-sitosterol. Enhance antiproliferative effects were observed when β-sitosterol was combined with camptothecin. β-sitosterol was also shown to inhibit the activity of glutathione S-transferases in the cancer cell line. The results of the study suggested that β-sitosterol has antiproliferative effects in the Jurkat-T cells. Further work needs to be done on normal cells to determine if β-sitosterol affects cancer cells only.
      PubDate: 2022-12-01
       
  • An overview on pharmaceutical properties and biotechnological advancement
           of Withania coagulans

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      Abstract: Abstract Withania coagulans is a therapeutic plant, commonly known as Rishyagandha. It is used in treatment of various diseases like indigestion, diabetes mellitus, liver disorders, purification of blood and controls blood pressure. In addition, it is reported to control plasma glucose levels and preventing renal complications. The plant contains various metabolites, and the most important being withanolides isolated from its fruits. Apart from above, the plant is known for its various pharmacological effects viz. cardioprotective, hepatoprotective, and anti-inflammatory activity. The current review includes information about pharmacological effects, therapeutic uses, extraction of plant metabolites and its use in treatment of various diseases. Furthermore, biotechnological advancement of W. coagulans has also been discussed.
      PubDate: 2022-12-01
       
  • Study of compounds, cytotoxicity and biological activities of essential
           oil of Satureja rechingeri Jamzad

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      Abstract: Abstract Nowadays, the essential oil has received a special position for the treatment of diseases. Although Satureja rechingeri Jamzad is an endemic species of Iran, unfortunately few studies have been conducted on its biological properties. In this study, along with the analysis of the compounds of Satureja rechingeri essential oil, cytotoxic, antioxidant and antibacterial properties of the essential oil of this species were investigated. The compounds of prepared essential oil were analyzed by GC-FID and GC–MS using Clevenger. Disc diffusion and MTT methods were used to determine the antibacterial activity and cytotoxicity of the essential oil, respectively. The antioxidant activity of the essential oil was measured by two methods of reducing power assay and DPPH free radical scavenging. p-Cymene (46.5%) was the most identified compound in the essential oil. The essential oil showed higher inhibitory effect on seven bacterial strains relative to the standard antibiotics. The studied essential oil showed significant concentration-dependent inhibitory effect on four cancer cells of Vero, SW480, MCF7 and JET3 with 50% lethal effect of 15.6, 125, 15.6 and 250 µg/mL for each line, respectively. The highest adsorption (2.6 nM) was at 500 µg/mL for reducing power assay and 50% free radical inhibition at a concentration of 375 µg/mL for DPPH antioxidant assay. In general, the essential oil of Satureja rechingeri with high antioxidant, antibacterial and anticancer activity can be used as a cheap and affordable natural product in clinical and pharmaceutical fields.
      PubDate: 2022-12-01
       
  • Evaluation of biologically active secondary metabolites isolated from the
           toothache plant Acmella ciliata (Asteraceae)

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      Abstract: Acmella ciliata (HBK) Cass. (basionym: Spilanthes ciliata HBK) is an herb of high medicinal value. Spilanthol, the prime N-alkamide in A. ciliata, is used as an active ingredient in several anti-ageing herbal tonics and in mouth washes. Here we describe quantification of spilanthol, phenolics, flavonoid and antioxidant activity in the methanol extracts prepared from flower, leaf, root and stem of the plant. HPLC of the sample extracts revealed that spilanthol was found to be maximum in flowers (18.44 mg/g), as compared to other parts of the plant as well as several of other Acmella (syn: Spilanthes) species. Estimation of phenolics and flavonoids in the extract by spectrophotometry with their values expressed respectively as equivalence of gallic acid (GAE) and quercetin (QE), revealed that phenolics content was highest in the flower extract (5.58 mg GAE/g), whereas, flavonoid content was found maximum in the leaf extract (31.65 mg QE/g). Antioxidant activity of the extract remained proportional to phenolic content of the extract. Flower extract further showed highest free radical scavenging activity in DPPH and ABTS assays, as compared to the extracts from other parts of the plant. Pearson’s correlation for antioxidant activity with respect to the phenolic and flavonoid content turned out to be positive. To the best of our knowledge this is the first report on quantification of the three secondary metabolites considered here and the antioxidant activity in the methanol extract prepared from different parts of A. cilitata. Graphic abstract
      PubDate: 2022-12-01
       
  • Antibacterial phytocomplexes and compounds from Psychotria sycophylla
           (Rubiaceae) against drug-resistant bacteria

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      Abstract: Abstract In this study, we examined the antibacterial and antibiotic-resistance reversal properties of methanol (MeOH) and ethyl acetate (EtOAc) extracts and compounds from Psychotria sycophylla aerial parts against drug-resistant bacteria. The tests were performed using the microdilution method. The mechanisms of action were investigated on growth kinetic and proton pumps of Escherichia coli. The structures of isolated compounds including oleanolic acid (1), ursolic acid (2), lupeol (3), betulinic acid (4), β-sitosterol glucoside (5), and stigmasterol (6), were established based on nuclear magnetic resonance (NMR) and electrospray ionization-mass spectrometry (ESI–MS). The extracts displayed noteworthy antibacterial activities, with recorded minimal inhibitory concentrations (MIC) ranging from 4 to 1024 µg/mL. Significant activities (MIC < 100 µg/mL) were obtained with the MeOH extract against Providencia stuartii PS2636 and Staphylococcus aureus MRSA9 (MIC of 16 µg/mL) as well as the EtOAc extract against S. aureus MRSA3 (MIC of 32 µg/mL) and Enterobacter aerogenes EA27 (MIC of 4 µg/mL). MeOH extract displayed a broad-spectrum antibacterial activity, acting against 21 out of 22 studied bacteria. The MICs of compounds (1–6) varied from 16 to 256 µg/mL. Oleanolic acid (1) appeared to be the most effective, preventing the growth of 100% of studied bacteria. The MeOH extract significantly enhanced the efficacy of conventional antibiotics against selected multidrug-resistant Gram-negative bacteria. The mechanistic investigations showed interference of MeOH with bacterial growth kinetic (by extending the lag phase) and inhibition of proton pumps. The current study provides a strong experimental baseline to consider P. sycophylla extracts and compounds as potent antibacterial natural products.
      PubDate: 2022-12-01
       
  • Curcuma longa extract ameliorates motor and cognitive deficits of
           6-hydroxydopamine-infused Parkinson’s disease model rats

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      Abstract: Abstract Parkinson’s disease (PD) results mostly from the degeneration of dopaminergic neurons in the substantia nigra pars compacta. It is characterized by the manifestations of anxiety, tremor, muscle rigidity, bradykinesia and cognitive impairments. Oxidative stress is attributed to the neurodegeneration of PD. Curcuma longa is a commonly used spice and has high levels of anti-oxidative phyto-constituents. Here, we evaluated whether the chronic oral administration of C. longa extract affects the degree of anxiety, neuromotor and cognitive deficits of 6-hydroxydopamine (6-OHDA)-infused PD model rats. Following the surgery, animals were orally administered with C. longa extract for twelve weeks. The degree of anxiety/depression, motor and cognitive performances were determined with a variety of neurobehavioral experimental paradigms, including elevated plus, Morris water maze task, rotarod, open field, forced swim, sucrose preference and tail suspension tests. Brain levels of lipid peroxide (LPO) were measured by standard method. Tumor necrosis factor-α (TNFα), α-synuclein, synaptosome-associated protein-25 (SNAP25) and brain-derived neurotrophic factor (BDNF) of the brain tissues were measured by ELISA. Oral administration of C. longa significantly (P < 0.05) protected the deterioration of the motor activity, learning-related memory cognitions and the degree of anxiety- and depression-like behaviors in PD model rats. The preventive effects were accompanied with decreased brain levels of LPO, TNFα, α-synuclein and increased levels of cognition-related proteins SNAP-25 and BDNF. The experimental results suggest that C. longa ameliorates PD-like symptoms by suppressing the oxidative/pro-inflammatory stress and levels of α-synuclein and increasing the levels of SNAP-25 and BDNF.
      PubDate: 2022-12-01
       
  • Test comparison of seeds and skins extract of duku’s fruit (Lansium
           domesticum Corr.) against the amount of melanin pigment of skin mencit
           (Mus musculus) to prevent premature aging of the skin

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      Abstract: Abstract Premature aging can occur due to excessive sun exposure which causes hyperpigmentation problems and causes brown or black patches on the skin. Duku (Lansium domesticum Corr.) contains flavonoids and vitamin C compounds that are effective in protecting the skin from sun exposure. This study aims to see the benefits of the extract of the seeds and peel of duku fruit (Lansium domesticum Corr.) On the amount of melanin pigment in the skin of mice (Mus musculus) as an anti-hyperpigmentation so that the dapjekal is a skin pen. Group P0 was a negative control, group P1 was exposed to sunlight for 20 days, group P2 mice were exposed to duku seed extract and then exposed to sunlight for 20 days, group P3 were exposed to duku peel and exposed to local sunlight for 20 days, P4 mice were exposed to sunlight 20 days, 21–30 days exposed to peel extract, and P5 mice exposed to sunlight 20 days, 21–30 days exposed to seed extract. The results showed that the P0 group had the amount of melanin pigment with an average of 7 grains, the P1 group: 68.4, P2 group: 26.6, P3 group: 29, P4 group: 7.2, and group P5 group: 12. The conclusion is that exposure to sunlight the amount of melanin pigment and offers the extract of the peel and seeds of duku fruit can reduce the amount of melanin pigment.
      PubDate: 2022-12-01
       
  • Acute and a 28-repeated dose toxicity study of commercial oleoresin from
           Copaifera sp. in rodents

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      Abstract: Abstract Copaifera spp. (copaiba) oleoresin is traditionally used as a medicinal compound since the 16th century, which is primarily indicated for its anti-inflammatory properties being widely sold in free fairs and medicinal herbal houses in Brazil. However, copaiba oleoresin toxicity information is still limited. In this study, we aimed to investigate the acute (in mice and rats) and 28 day—repeated doses (in rats) oral toxicity of commercial copaiba oleoresin. In the acute toxicity test, copaiba oleoresin oral administration at 2000 mg/kg dose did not induce mice or rat lethality. In the subacute toxicity tests, we administered copaiba oleoresin at daily doses of 25, 50, or 100 mg/kg for 28 days. We observed no toxicological effects in body weight gain, feed and water intake, gross necropsy, relative organ weight, histopathology, hematology, or biochemistry parameters. At the three copaiba oleoresin tested doses, we observed an alkaline phosphatase reduction, which might indicate hepatic protection. In conclusion, the commercial copaiba oleoresin has a low risk of toxicity and did not induce treatment-related adverse effects after short-term daily exposures to a dose two thousand times higher than folk use, showing safety doses for further pharmacological investigations.
      PubDate: 2022-12-01
       
  • Therapeutic role of medicinal plant extracts and bioactive compounds in
           osteoarthritis

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      Abstract: Abstract Osteoarthritis (OA) is a musculoskeletal disorder characterized by degeneration of articular cartilages facilitated by inflammation, cartilage and extracellular matrix degrading enzymes and chondrocyte dedifferentiation and depletion. The current therapy for OA failed to avert the degeneration of articular cartilage due to elusive molecular nature, multifarious signaling pathway and molecular targets implicated in this disease. These reasons are imposing hefty economic burden globally which necessitate for the discovery and development of multi-action drugs capable of stunting diseased condition. Medicinal plants accommodate various bioactive compounds that have a role in regulating inflammation and tissue regenerative properties. These compounds and plant extracts interact with multiple drug targets and disease pathways which make them attractive candidate for OA therapy. Recently, numerous compounds have been explored in OA induced animal and cell line models that significantly improved the cartilage integrity, extracellular matrix production and chondrocyte survival. In this review, we reviewed medicinal plant extracts and bioactive components and their therapeutic influence in OA therapy.
      PubDate: 2022-12-01
       
  • Diversity of medicinal plant traditionally used by Baiga tribes in
           District Umaria, Madhya Pradesh, India

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      Abstract: Abstract The conventional source of medicinal plants is an important way for daily curative uses in rural area throughout Madhya Pradesh. Folk medicinal specialists or traditional healer (Medicine men), assume an indispensable part in a medicinal services arrangement of both provincial and urban populace of the nation. It is vital to conduct broad meetings of individual medicine men of an area to get the overall status of medicinal plants. A survey was accomplished in the rustic territory of district Umaria, Madhya Pradesh. This investigation has uncovered a sum of 40 plants out of which 33 plants were identified, which belongs to 22 families. Whole plants and/or plant parts, like leaves, stems, barks, roots, flowers, fruits, seeds and wood were usually used by Biga tribe (Medicine men) for the treatment of different illnesses. Leaves (5%) were the most oftentimes used plant parts, trailed by roots (11%), fruits (3%) barks (5%), whole plants (3%), seeds (2%), latex (2%) and flowers (2%). Add up to 33 diverse individual illnesses professed to be restored by plant parts including Breast abscess, Cure carbuncle, Cure rheumatic, Cure scabies, Diabetes, Diarrhoea, Eczema, Haematuria, Headache, Jaundice, Leucorrhoea, Leukoderma, Menstrual disorder, Piles, Rat bites, Scorpion bite, Skin burns, Skin disease, Spermatorrhea, Stomachache, Toothache, Typhoid and fever, used to abortifacient, increase milk after delivery, Whooping cough and Wounds of animals. Several uses of the plants could be validated by available literature review. It is expected that other plants used for treatment of various diseases by the Biga tribes (medicine men) can be subjected for further bio-activity and phytochemical studies, which prompts disclosure of new medications.
      PubDate: 2022-12-01
       
  • Hepatoprotective potential of the n-butanol extract of Moricandia arvensis
           from Algeria against doxorubicin induced toxicity in Wistar albino rats

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      Abstract: Abstract Doxorubicin (DOX) is a potent anticancer drug; its use has been limited by its hepatotoxicity, which is due to free radicals generation. This work aims to investigate whether the n-butanol soluble part of the 70% methanol extract of the aerial parts of Moricandia arvensis, alleviates doxorubicin-induced hepatotoxicity. According to the literature data, Moricandia arvensis (Brassicaceae) is renowned for its richness in flavonoid and phenolic acid glycosides. In this work, we have rightly assessed the total phenolic and flavonoid contents of the studied extract (n-butanol extract). The results obtained (TPC: 86.25 ± 0.00 µg GAE/mg; TFC: 22.54 ± 0.01 µg QE/mg) encouraged us to continue our investigations. Wistar albino rats were orally administered with n-butanol extract of M. arvensis (50 mg/kg and 100 mg/kg body weight) or vitamin E as a standard antioxidant (100 mg/kg) for 10 days; and DOX (15 mg/kg on the 8th day that was intraperitoneally injected. At the end of the experiment, blood and liver samples were analyzed for biomarker levels and histopathological changes. Liver homogenates were used to determine oxidative stress parameters such as malondialdehyde (MDA), glutathione peroxidase (GPX) and glutathione (GSH) activity. DOX-administered rats significantly increased different levels of the serum biochemical parameters, increased TBARS level, decreased GPx activity and GSH level in the liver. In addition, M. arvensis (50 mg/kg and100 mg/kg) n-butanol extract treatments significantly decreased the level of TBARS, increased GSH level and GPx activity compared to the DOX-treated rats (p < 0.01). The histological study revealed the hepatoprotective effects of the tested extract on DOX-induced toxicity. This was demonstrated by the preservation of hepatic architecture as well as a reduction in structural and functional changes in the liver. The obtained results indicate a protective action of n-butanol extract of M. arvensis that could be the result of the inhibition of reactive oxygen species (ROS) generation. This may be the result of the presence of phenolic compounds in M. arvensis plant.
      PubDate: 2022-12-01
       
  • The GC–MS analysis of the diethylether and ethylacetate fraction of the
           peel of Solanum incanum and the study of their antibacterial activity

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      Abstract: Abstract The diethyl ether and ethyl acetate fractions of the peel of the fruit of Solanum incanum. (S. incanum) were analyzed using gas chromatography-mass spectrometry (GC–MS). 105 compounds were identified in the diethyl ether fraction and 75 compounds were identified in ethyl acetate fraction. Among them, 5 compounds were analyzed by fragmentation pattern, discussed, and compared with NIST database. The antibacterial screening was also conducted for bothdiethyl ether and ethyl acetate fractions of the fruit peel of S.incanum using four pathogens, two Gram-positive bacteria Staphylococcus aureus (S. aureus) and Streptococcus pyogenes (S. pyogenes) and two Gram negative bacteria Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumonia), at various concentrations (250, 500, 750 and 1000 μg/ml). The diethyl ether and ethyl acetate fractions of the peel of S. incanum exhibited activity against E. coli and K. pneumonia at 1000 μg/ml concentration.
      PubDate: 2022-12-01
       
  • Effectiveness and safety of Korean medicine for pain management after
           musculoskeletal surgery: a retrospective study

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      Abstract: Abstract To assess the effectiveness and safety of Korean medicine in managing postoperative pain. Retrospective, observational study. Medical records of 233 inpatients at a Korean medicine hospital who underwent Korean medicine treatments such as acupuncture, moxibustion, cuppping, bee-venom and herbal acupuncture, electrical therapy, herbal medicine, and carbon-beam therapy after musculoskeletal surgery were reviewed, and numeric ratings for pain were compared between baseline and follow-up. A correlation analysis between pain improvement and therapeutic factors was performed, and a regression analysis was conducted to determine the predictors of pain reduction. Serum laboratory test results at baseline and follow-up were subsequently compared to identify safety. Numeric rating scale scores for pain; presence of infection, drug-induced liver injury (DILI), and drug-induced kidney injury (DIKI) for safety. After Korean medicine treatment, the pain scores decreased from an average of 4.09 to 1.79 in the numeric rating scale (p < 0.001). Frequency of acupuncture therapy during hospitalization showed the strongest positive correlation with pain improvement (r = 0.341, p = 0.000) and was a predictor of pain reduction (adjusted R2 = 0.145). Improvements in serum laboratory data to reference limits were observed. All kappa coefficient values, except for white blood cell (WBC) count, were between 0.3 and 0.7, indicating that the follow-up data matched the baseline data. The low kappa coefficient value of WBC count was due to the high ratio of outliers. One (0.43%) and no cases of DILI and DIKI were identified, respectively. Korean medicine could be used for managing pain after musculoskeletal surgery.
      PubDate: 2022-09-27
       
 
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