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- Exosomes: Recent Advances and Challenges as Targeted Therapeutic Delivery
Vesicles-
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Authors: Sourabh Jadhav, Ankaj Kumar, Arvind Gulbake
Abstract: The exosome is a naturally derived nanostructured lipid vesicle that ranges from 40-100 nm in size and is utilized to transport drugs, and biological macromolecules, including therapeutic RNA and proteins. It is a membrane vesicle actively released by cells to transport cellular components with a purpose for biological events. The conventional isolation technique has several drawbacks, including low integrity, low purity, long processing time, and sample preparation. Therefore, microfluidic...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2023-04-19
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022044495
- Nanotherapeutic Approach to Delivery of Chemo- and Gene Therapy for
Organ-Confined and Advanced Castration-Resistant Prostate Cancer-
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Authors: Satish Sharma, Supriya D Mahajan, Kent Chevli, Stanley A Schwartz, Ravikumar Aalinkeel
Abstract: Treatments for late-stage prostate cancer (CaP) have not been very successful. Frequently, advanced CaP progresses to castration-resistant prostate cancer (CRPC), with 50#37;-70% of patients developing bone metastases. CaP with bone metastasis-associated clinical complications and treatment resistance presents major clinical challenges. Recent advances in the formulation of clinically applicable nanoparticles (NPs) have attracted attention in the fields of medicine and pharmacology with...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2023-04-19
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022043827
- Lignin-Based Nanomaterials as Drug Delivery Vehicles: A Review
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Authors: Tahmidul Islam Aquib
Abstract: Over the past decade, lignin-based nanomaterials have astonishingly gained tremendous popularity among researchers worldwide for utilization in various high-value added fields. However, the copiousness of published articles suggests that lignin-based nanomaterials are currently being given the most priority as drug delivery vehicles or drug carriers. A large number of reports have been published during the past decade reporting successful application of lignin nanoparticles as drug carrier, not...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2023-04-19
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022041829
- Theranostic Approach for the Management of Osteoporosis
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Authors: Anjali Pant, Joga Singh, Ravi Pratap Barnwal, Gurpal Singh, Bhupinder Singh
Abstract: Osteoporosis (OP) is a bone-metabolic disorder, causing micro-architecture degeneration and a decrease in bone density. Nutritional deficiency, i.e., calcium, vitamin D, and hormonal imbalances are the primary cause for the occurrence of OP. Although conventional diagnostic techniques and therapies are available and found to be effective only at a later stage, though still lack prevention strategies. Thus, the patients tend to suffer incidence of fractures and many difficulties to manage their...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2023-02-07
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022043413
- Exploring the Therapeutic Potential of Anticancer Heterocyclic Compounds:
Role in Nanoscale Pharmacotherapy-
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Authors: Lalit Kumar, Shivani Verma, Kajal Joshi, Sumit Sharma
Abstract: There are a large number of pharmaceutical products in the market containing heterocyclic compounds. Heterocyclic compounds are explored in the field of therapeutics due to their unique physicochemical and pharmacological properties. A large number of heterocyclic compounds existing in the pharmaceutical market have marked anticancer activity and many of them are under research investigations to treat different types of cancers. Anticancer heterocyclic compounds show many shortcomings such as...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2023-02-07
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022039548
- Implementation of Quality by Design in the Formulation and Development of
Nanocarrier-Based Drug Delivery Systems-
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Authors: Sonal Mehrotra, A Salwa, Lalit Kumar
Abstract: Quality by design (QbD) has recently fascinated researchers for utilizing it in various arenas of pharma trends. By overcoming the conventional process, QbD prevents the risk of errors caused by the 'guess and by god approach'. This framework fosters profound knowledge of product and process quality by implying sound science and risk assessment strategies. The virtue of QbD leads to the collaborative contribution to pharmaceutical industrialists and satisfies the regulatory bodies. Additionally,...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2023-02-07
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022042927
- Recent Advances and Prospects for Plant Gum-Based Drug Delivery Systems: A
Comprehensive Review-
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Authors: Minkal Tuteja, Kalpana Nagpal
Abstract: This work is an effort to first introduce plant-based gums and discussing their drug delivery applications. The composition of these plant gums and their major characteristics, which make them suitable as pharmaceutical excipients are also described in detail. The various modifications methods such as physical and chemical modifications of gums and polysaccharides have been discussed along with their applications in different fields. Consequently, plant-based gums modification such as...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2023-02-03
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022042252
- A Review on Recent Advances in Mannose-Functionalized Targeted Nanocarrier
Delivery Systems in Cancer and Infective Therapeutics-
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Authors: Vasanti Suvarna, Niserga Sawant, Namita Desai
Abstract: Unmodified nanocarriers used in the chemotherapy of cancers and various infectious diseases exhibit prolonged blood circulation time, prevent enzymatic degradation and increase chemical stability of encapsulated therapeutics. However, off-target effect and lack of specificity associated with unmodified nanoparticles (NPs) limit their applications in the health care system. Mannose (Man) receptors with significant overexpression on antigen-presenting cells and macrophages are among the most...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2023-02-03
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022041853
- Cyclodextrin-Based Arsenal for Anti-Cancer Treatments
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Authors: Hitesh Chopra, Ravinder Verma, Sakshi Kaushik, Jatin Parashar, Kumud Madan, Afsareen Bano, Rashmi Bhardwaj, Parijat Pandey, Beena Kumari, Deepika Purohit, Manish Kumar, Saurabh Bhatia, Md Habibur Rahman, Vineet Mittal, Inderbir Singh, Deepak Kaushik
Abstract: Anti-cancer drugs are mostly limited in their use due to poor physicochemical and biopharmaceutical properties. Their lower solubility is the most common hurdle limiting their use upto their potential. In the recent years, the cyclodextrin (CD) complexation have emerged as existing approach to overcome the problem of poor solubility. CD-based nano-technological approaches are safe, stable and showed well in vivo tolerance and greater payload for encapsulation of hydrophobic drugs for the...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2023-02-03
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022038398
- Peptides as Diagnostic, Therapeutic, and Theranostic Tools: Progress and
Future Challenges-
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Authors: Reena Thakur, Chander Raman Suri, Indu Pal Kaur, Praveen Rishi
Abstract: Peptides are emerging as a promising candidate for therapeutic as well as diagnostic applications within the domain of clinical and scientific research. They are recognized for being highly selective, sensitive and efficacious with minimal or no toxicity. Small size, non-immunogenicity, ease of synthesis and huge scope of modification are some of the well-established properties of peptides, which make them an excellent alternative to not only small drug molecules but also to protein-based...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-11-14
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022040322
- Armamentarium in Drug Delivery for Colorectal Cancer
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Authors: Asad Ali, Juber Akhtar, Usama Ahmad, Abdul Samad Basheer, Neha Jaiswal, Afroz Jahan
Abstract: Colorectal cancer (CRC) is the second most common cause of cancer related deaths in the United States. However, more than half of all incidence and mortality are caused by risk factors such as smoking, unhealthy diet, excessive alcohol consumption, inactivity, and excess weight, and thus can be protected. CRC morbidity and mortality can also be reduced by proper screening and monitoring. Over the last few years the amalgamation of nanotechnology with healthcare system has brought about the...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-11-14
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022039241
- The Role of Polymers and Excipients for Better Gastric Retention of
Captopril-
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Authors: Uddipta Das, Pankaj Wadhwa, Pankaj Kumar Singh, Dheeraj Varma Kalidindi, Kalpana Nagpal
Abstract: Captopril is an angiotensin-converting enzyme (ACE) inhibitor that prevents angiotensin I (ATI) from being converted to angiotensin II (ATII). However, it offers certain limitations like instability, dose dumping and burst release due to its usage in the native state. In the last two decades, different polymers and excipients have been used to make captopril more accessible and well-accepted. The present work discusses the efforts made by various scientists so far to make the oral administration...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-08-23
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022042122
- Grafting of Natural Polymers and Gums for Drug Delivery Applications: A
Perspective Review-
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Authors: Baburao N Chandakavathe, Ravindra G Kulkarni, Shivsharan B Dhadde
Abstract: Natural polymers have received more attention because of their advantages over synthetic polymers such as abundant availability, low cost, biodegradability and non-toxicity. However, natural polymers suffer some limitations such as drop-in viscosity upon storage, uncontrolled hydration, solubility, inability to perform under high temperature and pressure (thermal stability), etc. In many instances above mentioned drawbacks of natural polymers limits their applications in drug delivery systems....
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-08-23
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022035905
- Receptor-Targeted Surface-Engineered Nanomaterials for Breast Cancer
Imaging and Theranostic Applications-
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Authors: Javed Ahmad, Md Rizwanullah, Teeja Suthar, Hassan A Albarqi, Mohammad Zaki Ahmad, Parameswara Rao Vuddanda, Mohammad Ahmed Khan, Keerti Jain
Abstract: Breast cancer is one of the most frequently diagnosed cancers in women and the major cause of worldwide cancer-related deaths among women. Various treatment strategies including conventional chemotherapy, immunotherapy, gene therapy, gene silencing and deliberately engineered nanomaterials for receptor mediated targeted delivery of anticancer drugs, antibodies, and small-molecule inhibitors, etc are being investigated by scientists to combat breast cancer. Smartly designed/fabricated...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-08-23
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022040686
- Polymeric Nanoparticles: A Holistic Approach to Combat Tuberculosis
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Authors: Sarita Rani, Ashok Kumar Sharma, Raghu Kasu, Umesh Gupta
Abstract: The emergence of multidrug-resistant (MDR) and extremely drug resistant (XDR) forms of pulmonary tuberculosis (TB) remains a major health challenge in this advanced era of health science. The longer therapy and higher dose of anti-tubercular drugs (ATDs) increases the patient incompliance at its peak levels of intolerance as well as toxicity. In the recent decades, nanoparticulate drug delivery has emerged as an excellent venture for the effective treatment of cancer, infectious diseases, brain...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-08-22
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022039981
- Exploration of 3D Printing of Anti-Infective Urinary Catheters: Materials
and Approaches to Combat Catheter-Associated Urinary Tract Infections
(CAUTIs) - A Review-
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Authors: Archana Menon, Rubini Durairajan, Ramyadevi Durai, Nithyanand Paramasivam, VedhaHari B Narayanan
Abstract: Three-dimensional (3D) printing is a pioneering technology that has gained increased popularity in the fields of tissue engineering, drug design, drug delivery systems and biomedical devices. Thus, it enables us to explore this technique for fabricating 3D-printed catheters. Owing to its enhanced productivity and cost-efficiency, this technique can be utilized to fabricate any material for manufacturing or designing catheters with antimicrobial properties. From 1930s, Foley's catheter had been...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-08-22
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022040452
- Cyclodextrin-Based Supramolecular Ternary Complexes: Emerging Role of
Ternary Agents on Drug Solubility, Stability, and Bioavailability-
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Authors: Pooja Suvarna, Pinal Chaudhari, Shaila A Lewis
Abstract: The aqueous solubility of active drug moiety plays a crucial role in the development of an efficacious formulation. The poor aqueous solubility of BCS class II and IV drugs is manifested as poor bioavailability. Preparation of cyclodextrin inclusion complex to improve the solubility, stability, and bioavailability is a well-established technique. The latest trend in cyclodextrin research is focused on ternary complexes wherein an auxiliary agent such as water-soluble polymers, organic ions,...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-08-22
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022038870
- Recent Advancements in Electrospun Nanofibers for Wound Healing: Polymers,
Clinical and Regulatory Perspective-
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Authors: Zeeshan Patel, Sankalp A Gharat, Moawia M Al-Tabakha, Akram Ashames, Sai H S Boddu, Munira M Momin
Abstract: Wound management is an unmet therapeutic challenge and a global healthcare burden. Current treatment strategies provide limited efficiency in wound management, thus undergoing constant evolution in the treatment approaches. As wound healing is a complex physiological process involving precise synchronization of various phases like hemostasis, inflammation and remodelling, which necessitates innovative treatment strategies. Nanotechnology platforms like polymeric nanofibers (NFs) offer a...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-06-13
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022039840
- Crafting Immunological Response Using Particulate Vaccines
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Authors: Amit Bansal, Bernadette D'Souza, Deepak N Kapoor, Paritosh Singh, Gretchen Starr, Kiran Kumar Muppireddy
Abstract: To achieve optimal immunogenicity, particulates present a promising vehicle for antigen delivery and have the potential to skew immune response. Particulate vaccine offers several advantages including targeting of antigen to sentinel cells, protection from degradation, sustained release, and itself acts an adjuvant mimics viral structure. Adjuvant presence is vital in overcoming the poor immunogenicity of vaccines, e.g., subunit vaccines. Adjuvants have antigen dose sparing potential and provide...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-06-13
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022040656
- Exploring Liposomes for Lung Cancer Therapy
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Authors: Aisha Shahid, Mohd Muazzam Khan, Usama Ahmad, Md Faheem Haider, Asad Ali
Abstract: Cancer is referred to as a pleiotropic disease-causing approximately 9.6 million deaths in 2018. Among all cancers, lung cancer was the leading cause of death in 2017, and 12% of fatalities were alone due to lung cancer. The associated risk factors in lung cancer include smoking (80-85%), chronic inflammation in the lungs, COPD, pulmonary fibrosis, environmental and occupational exposure to nickel, arsenic, chromates, etc. Early diagnosed patients' treatment plan includes chemotherapy,...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-06-13
DOI: 10.1615/CritRevTherDrugCarrierSyst.2021037912
- A Review of Anti-Aging Nanoformulations: Recent Developments in Excipients
for Nanocosmeceuticals and Regulatory Guidelines-
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Authors: Vivek Basudkar, Sankalp A Gharat, Munira M Momin, Mihika Shringarpure
Abstract: Skin aging is the progressive biological process generally characterized by the appearance of wrinkles, age spots, sagging of skin, and dryness. Since skin is an essential part of physical appearance, this has led to increased concerns about skincare. Anti-aging products help in improving the quality and health of the skin by nourishing it. However, due to large particle size they are less efficacious. Nanotechnological approaches for topical anti-aging products have a significant effect on the...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-04-05
DOI: 10.1615/CritRevTherDrugCarrierSyst.2021039544
- Getting into the Brain: Are We in Yet or Just Knocking at the Door'
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Authors: Kalpana Nagpal, Dhirender Singh, Amit Bhatia, Pradeep Kumar
Abstract: Nanomedicine, a promising addition to the spectrum of biomedicine, has viewed countless breakthroughs in the implementations of "site-specific" drug delivery. The promises of nanomedicines revolve around their unique physicochemical properties that permit the transport of therapeutics to the desired site of action, improve the pharmacokinetic endpoint, maximize the pharmacological influence of treatment, and overcome the limitation of remedies that otherwise would impede the therapeutic...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-04-05
DOI: 10.1615/CritRevTherDrugCarrierSyst.2021038918
- Immunomodulation and Anticancer Immunity: Reviewing the Potential of
Probiotics and Their Delivery with Macromolecular Carriers-
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Authors: Sanjay Tiwari, Mitesh Dwivedi, Sachin Rathod, Pratap Bahadur
Abstract: Probiotics colonize in the gastrointestinal tract and regulate the homeostasis in healthy human hosts. These protect the host against putrefactive organisms and secrete soluble factors exhibiting important transductive roles. However, constitutive processes in human host are deregulated following dysbiosis caused during prolonged exposure to cytotoxic agents and pollutants. Apart from restoring the homeostasis, probiotic administration has shown to minimize carcinogenesis and post-surgery...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-04-04
DOI: 10.1615/CritRevTherDrugCarrierSyst.2021040045
- Self-Assembly Polymeric Nano Micelles for the Futuristic Treatment of Skin
Cancer and Phototoxicity: Therapeutic and Clinical Advancement-
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Authors: Navneet Mehan, Manish Kumar, Shailendra Bhatt, Ravi Shankar, Beena Kumari, Rakesh Pahwa, Deepak Kaushik
Abstract: In the last few years, the polymeric micelles played a major role as a drug carrier in nano-sized drug delivery system. The polymeric micelles are designed from synthetic block co-polymers and graft copolymers. In the mixed micelles, the bilayer lipid membrane and surfactants are used. Both micelles are in nano-sized and used to enhance the drug delivery to treat different diseases. In this review, we will discuss some examples from the literature included demonstrating the polymeric micelles...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-04-04
DOI: 10.1615/CritRevTherDrugCarrierSyst.2021035589
- Recent Progress in Self-Emulsifying Drug Delivery Systems: A Systematic
Patent Review (2011-2020)-
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Authors: Pedro Sebastián Londoño Ruiz, Mairim Russo Serafini, Izabel Almeida Alves, Diana Marcela Aragón Novoa
Abstract: Self-emulsifying drug delivery systems (SEDDS) are lipid-based isotropic mixtures that enhance the bioavailability of poorly water-soluble drugs and reduce the possible side effects, offering a wide variety of treatments for several pathologies. The aim of this review is to discuss the state of the art of patents for this drug delivery system by studying recent patent applications (2011 to 2020). We performed a thorough screening using the European Patent Office's Espacenet database, from which...
Citation: Critical reviews in therapeutic drug carrier systems
PubDate: 2022-04-04
DOI: 10.1615/CritRevTherDrugCarrierSyst.2021038490
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