 Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
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- Medical opioid disposal in Fukuoka and Kumamoto cities
Authors: Asami Ota, Shinnosuke Kurata, Kaho Tatsuma, Hinako Isaka, Yoshinori Higuchi, Takeshi Nishina, Keiko Haraguchi, Junichi Takaki, Taro Kihara, Taizo Tanaka, Tomoko Amagata, Ichiro Inaba, Takehiro Kawashiri, Daisuke Kobayashi, Takao Shimazoe
Abstract: Medical expenses are increasing year by year in Japan. However, the quantity of disposed medical opioids is not well known. In this study, we assessed disposed medical opioids in community pharmacies of Fukuoka city and in all of medical organizations of Kumamoto cities for 3 and 2 years, respectively. We collected official opioid disposal reports in Kumamoto city and Fukuoka City Pharmaceutical Association disposal information sheet in Fukuoka city. The total amount of disposed opioids was...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-08
DOI: 10.1248/yakushi.22-00199
- Identification of Risk Factors for Phlebitis in Patients Treated with
Nafamostat Mesylate
Authors: Kazumasa Kotake, Akihiro Tahira, Yasuhiro Kawakami
Abstract: The proteolytic enzyme inhibitor nafamostat mesylate is widely used for the treatment of acute pancreatitis and disseminated intravascular coagulation. This drug may be a risk factor for phlebitis, but this risk has not been studied. Therefore, we aimed to investigate the frequency of phlebitis and its risk factors in patients treated with nafamostat mesylate in intensive care units (ICU) or high care units (HCU). During the study period, 83 patients met the inclusion criteria, and 22 of them...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-06
DOI: 10.1248/yakushi.22-00201
- A Survey of Pharmacy Students' Satisfaction with a Basic Life Support
Course and an Exploration of Factors Related to Awareness Change Before
and After the Course
Authors: Atsushi Kinoshita, Kana Hashimoto, Megumi Yahara, Yurina Hashimoto, Mika Fukunaga, Tadashi Shimizu, Yoko Urashima, Tokio Obata
Abstract: The model core curriculum for pharmacy education and professional standards for pharmacists established by the Japan Pharmaceutical Association aim to inculcate knowledge and skills on basic life support (BLS) and ensure that pharmacy students are well equipped with knowledge on BLS. In this study, pharmacy students were enrolled in the PUSH course, a BLS training course for citizens, and a questionnaire survey was conducted before and after the course to evaluate the change in students...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00194
- Changes in Test Methods for Internationalization in the Japanese
Pharmacopoeia (Part 3): Establishment of a Quantitative Method for Sodium
Cromoglicate and Trihexyphenidyl Hydrochloride Using HPLC Analysis
Authors: Genichiro Tsuji, Takahito Ito, Nahoko Uchiyama, Junko Hosoe, Yosuke Demizu, Yukihiro Goda
Abstract: The Japanese Pharmacopoeia (JP) is an official normative publication for establishing the authenticity and properties and maintaining the quality of pharmaceutical products in Japan. The JP is revised every five years and partially revised in order to respond to the progress of science and technology, the demand for medical care, and international harmonization. Thus, "Internationalization of the JP" is one of the most important issues to address for the revision of the JP, which is also...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00188
- An Attempt to Build the Practice Model of Pharmacist in Home Care Medicine
for Children
Authors: Michiyo Kawana, Nobuko Sunami, Seishi Kishimoto, Machiko Watanabe
Abstract: Although the need for homecare medicine for children is increasing in Japan, few studies have focused on the role of pharmacists in this area. The purpose of the present study was to clarify the practice process of pharmacists in pediatric homecare medicine and develop a practice model. Three pharmacists with experience in homecare medicine for children participated in semi-structured interviews. The data were analyzed using the modified-grounded theory approach (M-GTA). The analysis generated 8...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00146
- Forty-three Years Cheerleading for Pharmacy Students and Pharmacists as an
English Teacher
Authors: Masako Horiuchi
Abstract: This review reflects on my 43 years of teaching and research at Showa Pharmaceutical University (SPU), Japan. As an English teacher, I have struggled with the question, "How can I, with no specialized knowledge of pharmacy, support pharmacy students and pharmacists'" During my career, a flood of reforms swept through English, university, and pharmacy education. I was able to survive thanks to the support of my teachers, colleagues, students, and alumni. I graduated from the Literature Department...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00148
- Hybrid Human Resource Development in the Combination of Clinical and
Graduate Research
Authors: Yutaka Inoue
Abstract: Changing workplace attitudes toward clinical research is fostered by trial and error providing optimal therapeutic backgrounds and diverse ideas. On the other hand, students have many opportunities to learn while in university, and we hope that they will have hopes to contribute to team medicine and community health care, and still develop a research mindset. As one of the ways to achieve these objectives, students can be exposed to clinical research from an early point by sharing information...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00169-4
- Developing Biomarkers in Precision Medicine for Asthma and COPD
Authors: Keita Hirai
Abstract: There is a growing demand for the implementation of precision medicine. There is an urgent need to move away from one-size-fits-all medicine, in which the treatment is based on the disease name alone, and to implement a precision-medicine approach. Chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) require a precision-medicine approach. Asthma and COPD are heterogeneous disorders with various phenotypes. In order to characterize the pathological features...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00169-3
- Utilization of Human iPS Cells for Evaluation of Drug Disposition and
Mucosal Damages in the Small Intestine
Authors: Takahiro Iwao
Abstract: The expression of multiple drug transporters and drug-metabolizing enzymes in the small intestine entails a detailed evaluation of the intestinal drug absorption in light of the contribution of these pharmacokinetic-related molecules. The intestinal mucosal damage and barrier disruption caused by diseases and xenobiotics influences health. Therefore, developing models to evaluate drug disposition and mucosal damage in humans is essential. We generated intestinal models from human induced...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00169-2
- Pharmacokinetic Study of Antiviral Drugs in Patients with COVID-19
Authors: Kei Irie
Abstract: The Faculty of Pharmaceutical Sciences, Kobe Gakuin University has collaborated in clinical research with Kobe City Medical Center General Hospital. In this university-medical institution collaboration, university faculty members discuss clinical problems with on-site pharmacists and doctors, and carry out clinical research to resolve these problems. During the coronavirus disease 2019 (COVID-19) pandemic, many patients with COVID-19 were treated at Kobe City Medical Center General Hospital. In...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00169-1
- Fusion of Basic and Clinical Research Based on Pharmaceutical Sciences
Authors: Kazuya Ooi, Ryuji Kato
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00169-F
- Evaluation of the Value of Chemotherapy
Authors: Hisanori Shimizu
Abstract: A pharmacist is "a person prepared to formulate, dispense, and provide clinical information on drugs or medications to health professionals and patients." A pharmacist is one member of the health care team, and he/she plays a key role in providing quality health and pharmaceutical care to the public. Health-related quality of life (HRQoL) is a useful indicator of a patients' overall health, and it can be estimated by questionnaire survey as patient-reported outcome. The development of an...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00160-5
- Patient Safety Management Practices by Community Pharmacy
Pharmacists～Telephone Follow-up by Community Pharmacy Pharmacists in
Cancer Drug Therapy～
Authors: Hayato Murata
Abstract: As a patient safety management practice in outpatient cancer drug therapy at community pharmacies, continuous follow-up after the dispensing of medication is required. In 2013, QOL Pharmacy Kohoku and its affiliated stores started the "Telephone Follow-up for Cancer Patients" program, which utilizes telephones and information communication devices to communicate with patients and provide information to hospitals. Specifically, follow-up, including phone calls, is used to ascertain medication...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00160-4
- Patient Safety Management Practiced by Pharmacy Pharmacists Using Their
Training at Oncology Hospital
Authors: Masanari Tsuji, Ryota Tsukioka, Miya Oishi
Abstract: Recent changes in the environment surrounding community pharmacists include "follow-up after dispensing" becoming mandatory, initiation of "certified pharmacy system with specific functions," with the discussions on post-graduate training, lifelong training and specialization, refill of prescriptions, as well as pros and cons of hospital pharmacies in preparation for the 2022 dispensing fee revision. In this regard, since 2019, I have been receiving training at The Cancer Institute Hospital of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00160-3
- Sharing Patient Safety Management Skills in Oncology Pharmaceutical
Outpatient Service
Authors: Kazuyoshi Kawakami
Abstract: Important tasks performed by pharmacists include dispensing medicines based on prescriptions and explaining medication to patients. However, pharmacists are now required not only to perform these tasks but also to provide patients with pharmacotherapy that maximises the efficacy of drugs and minimises side effects. In particular, chemotherapy has a wide variety of side effects and a higher incidence of side effects than pharmacotherapy for lifestyle-related diseases. The Cancer Institute...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00160-2
- Education Aimed at Patient Safety Management of Chemotherapy Conducted at
University Education Sites
Authors: Kenichi Suzuki
Abstract: The School Education Law was revised in 2006, and the university pharmacy education system and the national pharmacist examination system were changed. In line with the advancement of medical technology and the division of labor, 16 years have passed since the length of undergraduate pharmacy education was extended from 4 to 6 years in order to foster highly qualified pharmacists. During this period, the curriculum for practical training has been revised, and lectures and exercises focused on...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00160-1
- Considering the Next Generation of Cancer Drug Therapy Delivery by all
Pharmacists for Patient Safety Management
Authors: Kazuyoshi Kawakami, Satoko Hori
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00160-F
- Elucidation of Drug Transport Mechanism by Serum Protein and Development
for Pancreatic Cancer Treatment
Authors: Koji Nishi
Abstract: Human serum albumin (HSA) and α1-acid glycoprotein (AGP) are the major drug-binding proteins in the blood and regulate the tissue transfer of bound drugs. We succeeded in clarifying the three-dimensional structure of AGP for the first time in the world from X-ray crystal structure analysis. Using a site-directed mutagenesis method by constructing yeast expression systems as well as the three-dimensional structure, we elucidated the properties of drug binding sites of AGP. We also found that...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00173
- Elucidation of Physiological Functions of Vitamin K in the Brain and
Development of New Derivatives for Neuroregeneration
Authors: Yoshihisa Hirota
Abstract: Vitamin K plays an important role in blood coagulation and bone formation. However, apart from the liver and bone, the role of vitamin K in other tissues remains unknown. Previously, we have reported on high concentrations of vitamin K in the mouse brain and investigated vitamin K conversion in brain tissue. This led us to hypothesised the possibility of vitamin K contributing significantly towards maintenance and function of the cranial nervous system. In this review, we summarise the synthesis...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-03-01
DOI: 10.1248/yakushi.22-00187
- A Long-Term Study of the Reduction in Drug-Related Incident Reports and
the Impact on Patients by Pharmacist Intervention in the Emergency
Department
Authors: Masayuki Saito, Yoshihito Nakashima, Toshihiko Ichihara
Abstract: In Japan, pharmacists have begun working in emergency departments (ED) over the last decade. However, no reports exist on the contribution of pharmacists' activities in the ED to patient safety. We investigated whether pharmacists' long-term duties influence the number of incident reports in the ED. Of the 862 incidents reported, 152 (18.4%) were drug-related reports. Further investigations revealed that 42 cases occurred during pharmacists' usual working hours, four cases (9.5%) occurred when a...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-15
DOI: 10.1248/yakushi.22-00175
- Electrochemical Analysis Using Organic Nitroxyl Radicals
Authors: Tetsuya Ono
Abstract: Organic nitroxyl radicals represented by 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) are known to be compounds that catalyze alcohol oxidation reactions. These catalytic reactions can be applied to a wide range of compounds with hydroxy and amino groups. It is also possible to selectively oxidize primary alcohols by designing the skeleton around the nitroxyl radical moiety for use in organic synthesis. Reactions can also be carried out by electrochemical methods, and the electrical current...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00143
- Anti-inflammatory Effects of a Src Inhibitor on the Murine Model of Asthma
Exacerbation Induced by Ovalbumin and Lipopolysaccharide
Authors: Yuki Nishimoto, Genki Kimura, Kazuhiro Ito, Yasuo Kizawa
Abstract: Asthma is often exacerbated by airway infection, and some patients with severe asthma may be unresponsive to conventional corticosteroid treatment. Src family kinases (SFKs) were recently implicated in the inflammatory responses of mice induced by allergen and bacterial toxin lipopolysaccharide (LPS). Therefore, we examined the effects of dasatinib (DAS), a Src inhibitor, on airway inflammation in mice induced by ovalbumin (OVA) and LPS. Male A/J mice were sensitized to OVA Day -14 and -7,...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00190
- Survey of Prophylactic Administration of Naldemedine for Opioid-induced
Constipation
Authors: Yuki Ozawa, Yayoi Haruki, Meiko Ohata, Hisayo Isono, Minami Takahashi, Aki Tate, Seiko Ukita, Seiichi Hayashi
Abstract: Opioid-induced constipation (OIC), an adverse event that occurs due to opioid analgesics, reportedly causes poor quality of life and adherence to opioid analgesics in patients. Therefore, this issue must be addressed appropriately. Naldemedine (NAL), a peripherally-acting μ-opioid receptor antagonist, is currently recommended for treating OIC when other laxatives are ineffective, but there have been no clinical reports of NAL being used prophylactically for OIC. Therefore, we conducted a...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00181
- Survey on Visiting Nurses' Awareness of the Roles of Pharmacists in
Pediatric in-Home Care
Authors: Jotaro Baba, Michiyo Kawana, Nobuko Sunami, Kazuki Nagashima, Machiko Watanabe
Abstract: In recent years, there has been an urgent need to build a pediatric in-home care system with multiple occupations. This study aims to clarify the role of pharmacists in this system by investigating what visiting nurses' expectation from them. A self-administered questionnaire survey was conducted, targeting nurses enrolled in 10 home-visit nursing facilities. Responses were received from 51 nurses at six facilities, and the questionnaire collection rate was 42.5%. The primary role of the...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00100
- Effects of Coarse and Fine Atmospheric Particulate Matter on a Mast Cell
Line
Authors: Hiromi Kataoka, Kaori Tanaka, Keiko Tazuya-Murayama, Taku Yamashita, Jun-Ichi Nishikawa
Abstract: We investigated the cytotoxicity on a mast cell line (C57 cells) of water-soluble extracts of coarse (>3 µm, PM(>3)) and fine (0.05-3 µm, PM(0.05-3)) atmospheric particulates collected from April 2016 to March 2019 in Fukuoka, Japan. We examined the direct cytotoxicity with punched-out membrane filter fragments of PM(>3) and PM(0.05-3) collected from April 2019 to March 2021, without extraction of the components. Also, cell proliferation and degranulation assays were conducted under conditions...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00168
- Development of a Simple and Sensitive Enzyme-linked Immunosorbent Assay
for Sinomenine
Authors: Hiroto Kataoka, Kanae Ura, Tetsuya Saita
Abstract: Sinomenine (SIN) is a major component contained in extracts of the Chinese medicinal herb Sinomenium acutum. SIN has various pharmacological properties, including cytoprotection, immunosuppression and anti-inflammation effects. Furthermore, recent studies have reported that SIN has anti-tumor and antidepressant effects, which has created a strong need for SIN kinetic studies. This paper reports a simple and sensitive competitive enzyme-linked immunosorbent assay (ELISA) for the pharmacokinetic...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00164
- The Effects of Nanoparticles on Nerve Cell Differentiation and Its
Mechanisms for Human Health Risk Analysis
Authors: Kazuma Higashisaka
Abstract: Neurodevelopment is one of the most complex events in human growth and is very sensitive to disruption. Various genetic factors are the main causes of neuronal dysfunction; however, recent epidemiological studies have also revealed relationships between environmental factors and the onset of neurodevelopmental disorders. Humans are regularly exposed to a wide range of environmental factors, among which fine particles have attracted recent interest. In this regards, the development of products...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00156-3
- Understanding of Multiple Effects of Low Molecular Weight Compounds with
Factor Analysis
Authors: Tadahaya Mizuno, Shumpei Nemoto, Katsuhisa Morita, Hiroyuki Kusuhara
Abstract: The effects of drugs and other low-molecular-weight compounds are complex and may be unintended by the developer. These compounds and drugs should be avoided if these unintended effects are harmful; however, unintended effects are not always as harmful as suggested by drug repositioning. Therefore, a comprehensive understanding of complex drug actions is essential. Omics data can be regarded as the nonarbitrary transformation of biological information about a sample into comprehensive numerical...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00156-2
- Development of Serine Modification-based Kidney-targeted Drug Delivery
System
Authors: Hidemasa Katsumi, Masaki Morishita, Akira Yamamoto
Abstract: Kidney-targeted drug delivery is vital in treating kidney diseases by improving therapeutic efficacy and safety. However, targeting drugs to the kidney is challenging, as drug nano-carriers are usually trapped by the reticuloendothelial system in the liver and spleen. Recently, we reported that serine-modified polyamidoamine (Ser-PAMAM) dendrimer functions as a highly potent kidney-targeting drug carrier. Further, we demonstrated that Ser-PAMAM predominantly accumulated in the kidney, especially...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00156-1
- Evaluation of Health Impact and Risk Analysis of Chemical Substances
Authors: Kazuma Higashisaka, Takuya Yamashita
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00156-F
- A Study on Mechanisms Underlying Proton Transport in Proton Pump-type
Microbial Rhodopsins
Authors: Jun Tamogami
Abstract: Microbial rhodopsins are photoreceptive membrane proteins composed of seven transmembrane α-helical apoproteins (opsin) and a covalently bound retinal chromophore. Microbial rhodopsins exhibit a cyclic photochemical reaction referred to as photocycle when illuminated. During their photocycles, these proteins perform various functions such as ions transport and photosensing. Among the various functional types of rhodopsins found to date, we have focused on the utility of proton pump-type...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00184
- Development of Synthetic Methods for Heterocyclic Compounds Using the
Oxidative Rearrangement of Chalcones and Application to Total Synthesis
Authors: Akira Nakamura
Abstract: Chalcones are easily accessible synthetic building blocks that are used in various heterocyclic syntheses. The rearrangement reaction using an oxidant is a characteristic conversion of chalcones, but applications to organic synthesis have been limited. Here, the development of a new method for synthesizing 3-acylindoles and azaisoflavones using a chalcone rearrangement strategy with hypervalent iodine reagents was described. Furthermore, the obtained new insight was applied to the selective...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00154
- Evaluation and Clarification of Enterohepatic Interactions in
Pharmacokinetics
Authors: Hiroshi Arakawa
Abstract: The evaluation and prediction of pharmacokinetics in humans is important in the field of drug discovery and development. Generally, human pharmacokinetics is predicted using physiologically based pharmacokinetic models that include physiological and physicochemical (drug) parameters obtained from in vitro assays. Specific organ dysfunction, such as liver disease, also affects the functions of other organs, causing unexpected pharmacokinetic fluctuations. I investigated the effect of cholestasis...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-02-01
DOI: 10.1248/yakushi.22-00172
- Interaction of Phenytoin with Enteral Formulas, Proteins, and Dietary
Fiber in Vitro and in Vivo
Authors: Naoko Kuwabara, Miho Ohta-Shimizu, Fumiko Fuwa, Masami Tsugita, Noriyasu Sato, Shinji Sato, Saori Nakagawa
Abstract: Simultaneous administration of enteral formula and phenytoin in the clinical setting is known to reduce the plasma concentration of phenytoin. In this study, we examined the binding of phenytoin with enteral formulas and its components by quantifying the free phenytoin concentration. Furthermore, we investigated the effect of enteral formulas on gastrointestinal absorption of phenytoin in rats. The free phenytoin rate was reduced in vitro when phenytoin and enteral formula or pectin, a dietary...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00162
- Evaluation of Photostability of Small Molecular Compounds with Solid-state
UV Spectra
Authors: Akihito Kiguchiya, Reiko Teraoka, Tomoyuki Furubayashi, Toshiyasu Sakane
Abstract: It is crucial to evaluate the photostability of drugs. However, it requires a longer period of time to evaluate the photodegradation of compounds because extended light exposure to the compound is required to detect photodegradation products with the help of the commonly utilized technique of chromatography. Therefore, a simple and easy approach to estimate the photostability of the compound is required particularly for the initial screening of the drug candidates. It was reported in our...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00152
- Pathophysiology of Sandhoff Disease and Novel Thrapeutic Targets
Authors: Kazuhiko Oishi
Abstract: Sandhoff disease (SD) is a glycosphingolipid storage disease resulting from a genetic mutation in HEXB and associated deficiency in β-hexosaminidase activity. This defect causes abnormal accumulation of ganglioside GM2 and related glycolipids in lysosomes, resulting in progressive deterioration of the central nervous system. Hexb-knockout (Hexb^(-/-)) mice, an established animal model, show abnormalities similar to the severe phenotype seen in human infants. We used iPS cells derived from this...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00167
- Toward Regulatory Acceptance of MPS-Cardiac Safety Assessment as an
Example
Authors: Daiju Yamazaki
Abstract: Microphysiological system (MPS) are "Cell/tissue culture systems that reproduce in vivo organ functions in vitro by placing organ compartments that mimic the physiological environment of various organs such as the liver, small intestine, and lungs in micro-spaces." The MPS are attracting attention around the world as tools to improve human predictability in drug discovery research. In the U.S., in 2012, the NIH (National Institutes of Health) allocated a large budget to academia for research...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00161-3
- MPS for Blood Brain Barrier
Authors: Kaoru Sato, Michiya Matsusaki
Abstract: Blood brain barrier (BBB) is strong barrier specific to the brain vasculatures. BBB protects the brain from xenobiotics, while make it difficult to predict toxicokinetics/toxicodynamics, pharmacokinetics/pharmacodynamics, and efficiencies of new drugs in drug development. In this review, we will explain the physiological significance of BBB, the reason why the humanized BBB Micro Physiological System (MPS) is necessary, and the background technologies of BBB MPS. Because BBB MPS is the fusion of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00161-2
- Development of Microphysiological Systems (MPSs) Based on Microfluidic
Technology for Drug Discovery in Japan
Authors: Hiroshi Kimura
Abstract: Microphysiological systems (MPSs) based on microfluidic devices are attracting attention as an alternative cell assay platform to animal experiments in drug discovery. When we use microfluidic devices for cell culture, it is possible to experiment with various culture conditions that are difficult with conventional cell culture methods, such as fabrication of microstructures for cell placement, temporal and spatial control of liquid factors and adhesive conditions, and physical stimulation by...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00161-1
- Accelerate New Drug Development by Imitating the Biological Environment in
Micro-space-The Cutting Edge of MPS from Japan
Authors: Daiju Yamazaki, Seiichi Ishida
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00161-F
- Identification of Target Genes for Retinoid-related Orphan Receptors
Involved in the Suppression of Atherosclerosis
Authors: Hiroshi Matsuoka
Abstract: Retinoid-related orphan receptor alpha (RORα) participates in regulating several physiological processes, including metabolism and circadian rhythms. RORα is an important regulator of plasma cholesterol levels and is involved in lipid homeostasis. Its activation increases high-density lipoprotein (HDL) levels and metabolism of oxysterols. RORα-deficient mice develop atherosclerosis owing to decreased plasma HDL levels, increased expression of inflammatory cytokines, and...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00144
- Development of a Radioiodinated Probe for in Vivo Detection of Lipid
Radicals and Evaluation Using Middle Cerebral Artery Occlusion Model
Authors: Toshihide Yamasaki
Abstract: Free radicals, such as hydroxyl radical, superoxide, and lipid-derived radical, have unpaired electrons, making them a highly reactive chemical species. They play important physiological roles, for example, in the removal of xenobiotic substances, such as bacteria and viruses, and in the production of chemical mediators, like prostaglandins and leukotrienes. However, excessive production of free radicals can cause structural defects in biomolecules like DNA and proteins, resulting in a loss of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00137
- Development of Prediction Methods for Drug-Drug Interactions Based on the
Construction of Physiologically Based Pharmacokinetic Models for Hepatic
OATP Substrate Drugs and Endogenous Substrates
Authors: Takashi Yoshikado
Abstract: Quantitative prediction of the potential for drug-drug interaction (DDI) is essential to guarantee the safety and efficacy of drugs. DDI screening, modeling, and prediction is standard practice in the pharmaceutical industry. This review describes our work on (1) the establishment of a standard framework for determining physiologically based pharmacokinetic (PBPK) model structures and parameters useful for quantitatively analyzing DDIs via hepatic organic anion transporting polypeptides (OATPs)....
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00145
- Approaches to Pharmaceutical Education and Research from the Perspective
of Patients and Consumers
Authors: Hidehiko Sakurai
Abstract: This review introduces two sets of research results, one regarding patients' and consumers' perceptions of the pharmacist profession and pharmacy function, and the other regarding factors that influence patients' medication-taking behavior. First, as an example of what was examined from patients' perspectives regarding the pharmacist profession and pharmacy function, an analysis of patient response data before the introduction of the family pharmacist/pharmacy system is presented. The results...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2023-01-03
DOI: 10.1248/yakushi.22-00126
- A Bibliometric Analysis of Research Paper Productivity of Japanese
Pharmacy Schools
Authors: Rei Honda, Yuki Matsubara, Takashi Kubota, Hirofumi Konno, Yutaka Kirino, Yasushi Kishimoto
Abstract: Since the early 2000s, Japan has been frequently noted as being the only country among about 20 major countries where the publication of academic papers has stagnated. During this period, there have been major changes especially with regards to the Japanese pharmacy schools, such as the shift to a six-year schooling system and the rapid increase in the number of private pharmacy schools. However, few studies have focused on academic productivity specifically among pharmacy schools. Therefore,...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-12-27
DOI: 10.1248/yakushi.22-00149
- IFN-γ and IL-12 from Concentrated Ascites in Patients with Pancreatic
Cancer Exerts Growth Inhibitory Effects against Pancreatic Cancer Cells
Authors: Takuro Kobori, Chihiro Tanaka, Yoko Urashima, Nobumasa Takagaki, Tokio Obata
Abstract: Patients with pancreatic cancer (PC) often suffer from refractory ascites associated with peritoneal metastasis. This severely impairs activities of daily living and leads to an unfavorable prognosis. Cell-free and concentrated ascites reinfusion therapy (CART) has attracted attention as a promising therapy for relieving the symptoms of malignant ascites. Accumulating evidence suggests that malignant ascites contains a variety of soluble factors, such as cytokines, that can be beneficial or...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-11-30
DOI: 10.1248/yakushi.22-00150
- Comparison between Single and Three Times Pre-operative Administration of
Amoxicillin in the Prophylactic Effects for Surgical Site Infections in
Japanese Patients with Mandibular Third Molars Extraction
Authors: Kensuke Yoshida, Yasumitsu Kodama, Chie Saito, Kei Tomihara, Akira Toyama
Abstract: Although the dosage of oral antibiotics (OA) for the mandibular third molar extraction (MTME) varies among the administration periods according to the current guideline, our previous reports suggested that it might be possible to further shorten the administration period without increasing the incidence of surgical site infection (SSI). In the present study, we retrospectively evaluated the relationship between the incidence of SSI and the administration period of OA in patients who underwent...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-11-30
DOI: 10.1248/yakushi.22-00163
- Current Status of Formulary in Japan and the Assessment of Various Value
Components of Medicines
Authors: Ataru Igarashi
Abstract: Development of a formulary is an important issue to achieve rational use of medicines in each local medical area in Japan. The purpose of developing the formulary is to secure the access for safe, effective, and affordable medications based on evidence for patients, families, healthcare professionals as well as for general publics. The economic aspect plays an important role for the establishment of the formulary, while the word "economic" is often misread as simple "cost reduction", which only...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-11-30
DOI: 10.1248/yakushi.22-00127
- Benefits of Green Tea: Clinical Evidence for Respiratory Tract Infections
Authors: Hiroshi Yamada
Abstract: Green tea components, such as catechins have been reported to provide several benefits including anti-oxidative, anti-viral/bacterial, and anti-inflammatory effects in vitro and in vivo. Catechins effectively inhibited the adsorption and replication of the influenza virus. Additionally, green tea contains theanine and vitamin C, which enhance the immunity against viral/bacterial infections. Based on these, green tea is hypothesized to have potential benefits in the prevention of influenza and...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-11-30
DOI: 10.1248/yakushi.22-00153
- Attempt to Create a Drug for Treatment of Fibrotic Diseases Based on the
Non-genomic Action of Nuclear Receptors
Authors: Hiroyuki Miyachi
Abstract: Nuclear receptors are ligand-dependent transcription factors that act as signal transducers by binding to and regulating the transcription of target DNA (genomic action). In recent years, nuclear receptors have also been found to exhibit a direct action on target proteins without affecting their transcription (non-genomic action). Independent complexes are expected to distinguish these two nuclear receptor actions. In this paper, I report the non-genomic action of peroxisome...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-11-30
DOI: 10.1248/yakushi.22-00159-4
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