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- Impact of the Antimicrobial Stewardship Team Intervention Focusing on
Changes in Prescribing Trends and the Rate of Carbapenem-resistant P.
aeruginosa
Authors: Yuika Naito, Masayuki Maeda, Yasuhiro Nagatomo, Kazuhisa Ugajin, Etsuko Akima, Michiko Tanaka, Issei Tokimatsu, Tadanori Sasaki
Abstract: Antimicrobial stewardship (AS) intervention strategy is a critical process in promoting appropriate antibiotic use, thus preventing unnecessarily prolonged therapy and reducing antimicrobial resistance (AMR). Although limiting unnecessary carbapenem use by AS intervention is speculated to reduce AMR, there is a lack of specific data on the efficacy of AS team (AST) intervention regarding carbapenem-resistant Pseudomonas aeruginosa (CRPA). Consequently, this study aimed to evaluate the impact of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00202
- Pharmacological Cognitive Enhancement: Current Situation and Perspectives
Authors: Midori Yamamoto
Abstract: Pharmacological cognitive enhancement (PCE) refers to the use of biochemical enhancers for achieving improved mental performance in healthy individuals. One particular use of PCE prevalence is the misuse of these enhancers among university students for academic performance enhancement. The prevalence rates demonstrate the use of a broad spectrum of substances for PCE that can be classified as OTC, prescription, and illegal drugs. Given that certain substances have been widely used for years,...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00195
- Photopharmacological Tools for Mitotic Cell Division
Authors: Kazuya Matsuo
Abstract: Genetic information is replicated and transmitted from a parent cell to two identical daughter cells through mitotic cell division. To accomplish this dynamic process with high accuracy and precision, various motor proteins work in a concerted manner. Especially in the metaphase, mitotic chromosomes are delivered by the motor protein of centromere-associated protein E (CENP-E) to the cell equatorial plane (metaphase plate) along mitotic spindles. However, the critical functional failure of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00203-5
- Development of Photoresponsive Probes to Investigate Cellular Functions
Authors: Shin Mizukami
Abstract: Technologies for the optical control of biomolecular functions have recently attracted considerable attention because they can be combined with advanced laser and microscopic techniques for diverse applications at the cellular and intravital levels. In this account, I review the summary of optical control technologies for biomolecular functions based on organic chemistry or protein science, and then introduce our recent studies on the development of small molecule-based photoregulation...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00203-4
- Design and Synthesis of Gene-directed Caged Compounds toward
Photopharmacology
Authors: Toshiaki Furuta
Abstract: Photoresponsive molecules can be used to manipulate the physiological functions of cells with high spatiotemporal resolution. Caged compounds are photoresponsive molecules designed to temporarily mask their original biological activity through covalently bound photoremovable protecting groups. The introduction of additional properties into caged compounds without compromising photosensitivity would help expand the repertoire of caging groups. Therefore, we designed a modular caged compound...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00203-3
- Visualization of Enzymatic Reaction by Time-resolved Structural Analysis
with Photosensitive Caged Substrate
Authors: Takehiko Tosha
Abstract: Elucidation of molecular mechanism for metalloeznyme-catalyzed reactions is longstanding topics in the bio-inorganic chemistry field, since metalloeznymes play pivotal roles in various biological processes and catalyze reactions with high efficiency under mild conditions. Structural determination of reaction intermediates is key to visualizing the reactions catalyzed by metalloenzymes. Although it is not easy to determine the structure of the transient species by conventional crystallography,...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00203-2
- What Kind of Measurements Can Be Made with an X-ray Free Electron Laser at
SACLA'
Authors: Toru Nakatsu
Abstract: Three-dimensional structural information is indispensable to understand the function of proteins in living organisms and X-ray crystallography plays a major role in determining the three-dimensional structure. X-ray free-electron laser (XFEL), which is intense and femtosecond X-ray pulses, enables us to obtain X-ray diffraction intensity data before the destruction of protein molecules, and is expected to be a technology to obtain dynamic structural information. This year marks the 10th...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00203-1
- Frontier of Photopharmacology for High-speed Molecular Movies of Proteins
Authors: Hideko Nagasawa, Shigeki Kiyonaka
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00203-F
- Role of Fatty Acid Elongase Elovl6 in the Regulation of Fatty Acid Quality
and Lifestyle-related Diseases
Authors: Takashi Matsuzaka, Hitoshi Shimano
Abstract: The increasing prevalence of obesity worldwide has become an alarming public health concern because of dramatic increases in the incidence of obesity-associated diseases, including type 2 diabetes mellitus (T2DM). Peripheral insulin resistance and impaired insulin secretion remain the core defects in T2DM. Despite significant advances in unraveling the mechanisms underlying these defects, many of the metabolic pathways and regulators involved in insulin resistance and β-cell dysfunction are not...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00176-4
- Metabolism-dependent Vascular Pathophysiology in Adult Diseases
Authors: Akifumi Kushiyama, Masahiro Takahashi, Sakura Kushiyama, Takako Kikuchi, Tomoichiro Asano
Abstract: In adult diseases, chronic inflammation-related angiopathy is the main pathological condition of organ disorders such as arteriosclerosis, chronic kidney disease, and non-alcoholic steatohepatitis (NASH). Macrophages play an important role in chronic inflammation. For example, macrophage foaming is important for atherosclerosis development. In our study using Apolipoprotein E knockout mice, hyperglycemia caused by the administration of nicotinamide-streptozotocin, which is a non-obese type 2...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00176-3
- Involvement of Diacylglycerol Kinase on the Regulation of Insulin
Secretion in Pancreatic β-Cells during Type 2 Diabetes
Authors: Yukiko K Kaneko, Toshiaki Sawatani, Tomohisa Ishikawa
Abstract: Depression of lipid metabolism in β-cells has been indicated to be one of the causes of impaired insulin secretion in type 2 diabetes. Diacylglycerol (DAG) is an important lipid mediator and is known to regulate insulin secretion in pancreatic β-cells. Intracellular DAG accumulation is involved in β-cell dysfunction in the pathogenesis of type 2 diabetes; thus, the regulation of intracellular DAG levels is likely important for maintaining the β-cell function. We focused on diacylglycerol kinases...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00176-2
- Prolyl Isomerase Pin1 Impacts on Metabolism in Muscle and Adipocytes
Authors: Yusuke Nakatsu, Tomoichiro Asano
Abstract: Prolyl isomerase Pin1 is associated with various substrates and controls their functions through the isomerization of proline. Interestingly, a high fat diet increases Pin1 levels in adipose tissues. Accordingly, we investigated how Pin1 regulates energy metabolism in adipose tissues. Currently, adipocytes are divided into three types with distinct features. White adipocytes (WATs) store energy as triglycerides under fed conditions and release non-esterified fatty acids and glycerol through...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00176-1
- Recent Advances in the Studies of Metabolic Syndromes and Applications to
the Development of New Drugs
Authors: Akifumi Kushiyama, Yusuke Nakatsu
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00176-F
- Discovery of Diverse Natural Products from Undeveloped Fungal Gene
Resource by Using Epigenetic Regulation
Authors: Teigo Asai
Abstract: Discovery of natural products that possess novel chemical structures and pharmaceutical activities increases opportunities of drug development. Filamentous fungi have been recognized as an attractive source for pharmaceutically beneficial natural products. Genome sequencing innovation represented by Next-generation sequencer opened fungal genomes one after another, suggesting that one fungal strain has far more biosynthetic gene clusters than that are estimated from the number of previously...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00218
- Isoform Selectivity of HDAC Inhibitors Has a Significant Effect on PD-L1
Expression in the Triple-negative Cancer Cell Line MDA-MB-231
Authors: Hinata Nishino, Yoshiyuki Hirata, Yasuo Nagaoka, Shinichi Uesato
Abstract: Various reports have been published in recent years on the effects of histone deacetylase (HDAC) inhibitors on programmed death ligand 1 (PD-L1) expression in cancer cells. The combination therapy of immune checkpoint inhibitors and HDAC inhibitors utilizing these effects has attracted attention as a new clinical treatment of triple-negative breast cancers. We investigated how the expression level of PD-L1 changes depending on the type of HDAC inhibitor exposed to triple-negative breast cancer...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00213
- Impact of Change in Community Pharmacists' Role on Their Estimated Demand
Authors: Keiko Konomura, Yasuhiro Morii, Manabu Akazawa
Abstract: Pharmacists play a key role in optimizing the safe and effective use of medicines in the super-aged society in Japan. Recently, community pharmacists' role has been transformed and expanded to provide patient-centered care. This study aimed to simulate a change in the demand for community pharmacists resulting from this shift in their role, from 2019 to 2035. The change in demand was estimated by the number of prescriptions obtained from publicly available sources of information. The number of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00150
- Clinical Functionality of Dispersive OVDs: Improvement of One of the
Properties of 3% Hyaluronic Acid and 4% Chondroitin Sulfate Combination
Authors: Ippei Watanabe, Kiyoshi Suzuki, Mayumi Nagata, Hiroyuki Matsushima
Abstract: Ophthalmic viscosurgical devices (OVDs) are mainly divided into two general categories: cohesive and dispersive. Dispersive OVDs such as the 3% hyaluronic acid and 4% chondroitin sulfate (HA/CS) combination have excellent adhesion to ocular tissues and protect the corneal endothelium to a greater extent than cohesive OVDs. Herein, we summarize our recent findings regarding one of the properties of the HA/CS combination related to clinical performance. (i) The room temperature stability of OVDs...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00208
- Inclusion Solves Insolubility -Translational Research Cycle from Bedside
to Bench and Bench to Bedside for Drug Development Targeting Niemann-Pick
Disease Type C
Authors: Tetsumi Irie
Abstract: Cyclodextrins (CDs) are used not only as pharmaceutical excipients but also as active pharmaceutical ingredients. CDs can act as artificial carriers or shuttles to ameliorate lipid transport disorders. Niemann-Pick disease type C (NPC) is an inherited, progressive neurodegenerative disorder caused by mutations in NPC1 or NPC2 genes, in which unesterified cholesterol accumulates in lysosomes and the transport of cholesterol from lysosomes to the endoplasmic reticulum is impaired....
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00215
- Role of Glycoconjugates and Mammalian Sialidases Involved in Viral
Infection and Neural Function
Authors: Takashi Suzuki
Abstract: Glycoconjugates are present in various organisms, ranging from animals to viruses. Glycoconjugates are involved in several biologically significant functions, including viral infection and neurotransmission. However, the role of glycoconjugates in virus replication and neural function remains unknown. We discovered that the influenza A virus (IAV) binds to sulfatide, which lacks a sialic acid residue, and that delivering sulfatide combined with newly synthesized IAV hemagglutinin (HA) to the...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00212
- Improvement in Aqueous Solubility of Bioactive Molecules by Decreasing
Intermolecular Interaction
Authors: Minoru Ishikawa
Abstract: Sufficient aqueous solubility is a key requirement for small molecular drug candidates, and improvement of the aqueous solubility of bioactive compounds is often a major issue for medicinal chemists. Decreasing the partition coefficient (Log P) by the introduction of a hydrophilic group is the conventional approach for improving the aqueous solubility of drug candidates, but is not always effective. On the other hand, the solubility of a solid solute in water is also dependent on the crystal...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00185-3
- Bridge between Total Synthesis of Bioactive Natural Products and
Development of Drug Leads
Authors: Satoshi Ichikawa
Abstract: Although natural products are rich sources for drug discovery, only a small percentage of natural products themselves have been approved for clinical use, thus it is necessary to modulate various properties, such as efficacy, toxicity, and metabolic stability. A question in natural product drug discovery is how to logically design natural product derivatives with desired biological properties. This review describes our recent studies regarding the medicinal chemistry of tunicamycin. Tunicamycin...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00185-2
- Engineered Biosynthesis of Microbial Medicinally Active Compounds
Authors: Takayoshi Awakawa
Abstract: Natural products are an important source of medicinal seeds. The discovery of novel biosynthetic enzymes from nature is important for their use as biocatalysts for the enzymatic synthesis of useful natural products. In this review, I describe our recent research on the exploitation of a novel secondary metabolite enzyme and the production of unnatural bioactive products in the microbial host, as presented in the S02 symposium in the 141st annual meeting in the Pharmaceutical Society of Japan.
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00185-1
- Frontier Researches in Medicinal Chemistry Contribute to the Field of
Pharmacy
Authors: Takahiro Shirai
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00185-F
- Analysis of Information on Drug Adverse Reactions Using U.S. Food and Drug
Administration Adverse Event Reporting System (FAERS)
Authors: Daisuke Nango, Tuyoshi Sekizuka, Makoto Goto, Hirotoshi Echizen
Abstract: Nowadays, medical big data has been developed and made available in a variety of fields such as epidemiology and pharmacovigilance. Spontaneous reporting databases are one category of medical big data and that has been adequate for analysing events related to side effects that rarely occur in general practice. These data are freely available in several countries. In Japan, the Pharmaceuticals and Medical Devices Agency has developed the Japanese Adverse Drug Event Report (JADER), and the Food...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00178-5
- Development of Clinical Pharmaceutical Services via Artificial
Intelligence Adaptation
Authors: Hiroyasu Sato
Abstract: Recently, social implementations of artificial intelligence (AI) have been rapidly advancing. Many papers have investigated the use of AI in the field of healthcare. However, there have been few studies on the adaptation of AI to clinical pharmaceutical services. We reported attempts to adapt clinical pharmaceutical services with AI in the following areas of machine learning application in prescription audits: solutions for pharmaceutical problems via speech recognition and automatic assignment...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00178-4
- Clinical Research Using the Large Health Insurance Claims Database
Authors: Yoh Takekuma, Shungo Imai, Mitsuru Sugawara
Abstract: The JMDC Claims Database^(®) contains completely anonymized receipt information on the insured members of health insurance associations. The number of registered users is approximately 9.6 million (6% of the population) as of May 2020. In this database, it is possible to track even outpatient treatment, even if the patient changes the medical facility, as long as the insurer of the subscriber's health insurance does not change, so that long-term medical treatment could be targeted as a research...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00178-3
- Evidence for Proper Use of Medicines Using Medical Big Data: Formulary in
a Clinical Setting Using Medical Big Data
Authors: Kenji Momo
Abstract: Medical big data are accumulated daily by medical staff in clinical settings. We developed a formulary in 2016 using medical big data from eight hospitals affiliated with Showa University, Japan (3200 beds). In 2019, we revised the procedure from the perspective of authenticity, reproducibility, and clarity to develop a medicine formulary with unbiased data. Briefly, we organized two teams of expert physicians. Team 1 was a systematic review team that conducted a literature search using...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00178-2
- Medical Big Data Analysis Using Machine Learning Algorithms in the Field
of Clinical Pharmacy
Authors: Yoshihiro Kiryu
Abstract: Industrial reforms utilizing artificial intelligence (AI) have been progressing remarkably around the world in recent years. In medical informatics, the application of medical big data analytics using AI is also being promoted, and it is expected to provide screening methods for predicting potential adverse drug reactions (ADRs) and discovering new effects. Previously, we developed a unique ADRs analysis system that incorporates Accord.NET, an open-source machine learning (ML) framework written...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00178-1
- Quality Improvement for Clinical Practice and Advancing Research by
Clinical Pharmacists Using Medical 'Big Data'
Authors: Kenji Momo, Yoh Takekuma
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00178-F
- Growth and Control of Catheter-related Bloodstream Infection Causing
Bacteria in Nutrient Solutions
Authors: Hiroshi Ohara
Abstract: Among healthcare-associated infections, catheter-related bloodstream infection (CRBSI) shows a high case fatality rate and is serious threat. CRBSI are a problem to be eradicated. This study was conducted to reveal the growth characteristics of the causative microorganisms of CRBSI and investigate relevant control methods. The effects of biotin on growth of Candida albicans (C. albicans) in the nutrient solutions were investigated. Upon comparing general solutions and biotin-containing...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-04-04
DOI: 10.1248/yakushi.21-00184
- Inhibition of TRPV2 Channel Activation by NK-4, a Cryptocyanine Dye
Authors: Satomi Koya-Miyata, Keizo Kohno, Takashi Morimoto, Akira Harashima, Yuko Iwata, Toshio Ariyasu
Abstract: Transient receptor potential vanilloid 2 (TRPV2) channels are expressed and play functional roles in various immune cells. Physical stimuli leading to TRPV2 activation causes mast cell degranulation. Besides their roles in immune cells, it has been shown that TRPV2 channels are pathophysiologically relevant to degenerative muscular diseases such as dilated cardiomyopathy and muscular dystrophy. Hence, development of drug candidates that inhibit human TRPV2 activation is an urgent matter. NK-4, a...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00219
- Identification Methods for Pseudo-crystalline Polymorphs of Thiamine
Chloride Hydrochloride, Which Transform Easily Depending on the Handling
Environment
Authors: Ayano Yamada, Nagisa Murao, Akihiro Sato, Yuzo Fujimoto, Yukari Nakagawa, Tsuyoshi Tanimoto
Abstract: Three forms of pseudo-crystalline polymorph of thiamine chloride hydrochloride are dependent on hydration states. We investigated how the measurement environment affects the transition of the pseudo-crystalline polymorph, and aimed to establish a reliable method of identifying the forms clearly by IR spectrophotometry. We prepared three pseudo-crystalline forms and compared their IR spectra. In the IR spectra obtained by the potassium chloride (KCl) disk method, Form II was identified based on...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00206
- Efficacy of the Extract from Fermentation of Soybean and Rice Bran on
Hyperglycemia
Authors: Teppei Kaku, Miiru Suzuki, Takanari Tominaga, Akio Ogawa, Atsushi Shimizu, Kazutaka Watanabe, Kazuaki Watanabe, Tomoji Maeda, Yoshikazu Matsuda
Abstract: In recent years, lifestyle-related diseases such as hypertension and diabetes have been on the rise. These conditions can cause serious conditions such as myocardial and cerebral infarctions. Therefore, proper control of blood pressure and blood glucose levels is important issues in preventive medicine. Traditional fermented foods have been shown to have various functions, and their effects on lifestyle-related diseases have attracted particular attention. In this study, we investigated the...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00189
- Analysis of Flame Retardants Bis(2,3-dibromopropyl) phosphate and
Tris(2,3-dibromopropyl) phosphate in Textile Products by GC-MS
Authors: Tomoko Ooshima, Naoya Kakutani, Yukihiko Yamaguchi, Tsuyoshi Kawakami
Abstract: The use of flame retardants, namely bis(2,3-dibromopropyl) phosphate (BDBPP) and tris(2,3-dibromopropyl) phosphate (TDBPP), in textile products such as curtains, carpets and sleeping clothes is banned in Japan under the 'Act on the Control of Household Products Containing Harmful Substances'. Herein, we developed a GC-MS based method to quantify these compounds with greater accuracy and safety than the current official method. For accurate and sensitive quantification, deuterated compounds,...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00197
- Synthetic Studies on Small Molecule Natural Products with Neurotrophic
Activity
Authors: Yoshiyasu Fukuyama
Abstract: Neurotrophic factors have been shown to potentially be beneficial for the treatment of neurodegenerative diseases such as Alzheimer's disease, because endogenous neurotrophic factors (NGF, BDNF) have been recognized to play critical roles in the promotion of neurogenesis, differentiation, and neuroprotection throughout the development of the central nervous system. However, high-molecular-weight proteins are unable to cross the blood-brain barrier and are easily decomposed under physiological...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00201
- Unintended Observations Leading to Macrophage Growth and Neutrophil Factor
Research
Authors: Satoru Yui
Abstract: My research area in the pharmaceutical industry is innate immunity, especially in phagocytic cells. First, I studied the heat-stable growth factor of peripheral macrophages in tumorous ascitic fluid and found that lipoproteins are an influencing factor. Later, my colleagues and I found that lipid-containing substances, namely, oxidized low-density lipoprotein, dead neutrophils, or purified lipids that could be scavenged by macrophages, induce their growth. From the series of this study, I...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00191
- How Should Pharmacists Use the Evidence in the Community-based Integrated
Care System'
Authors: Soichiro Isobe
Abstract: Regarding the Separation of Dispensing and Prescribing (SDP) in Japan, there are some negative opinions that the value of separating these services has not been commensurate with the cost. On the other hand, there is substantial data showing the current state of SDP and its merits, which has been collected and published in academic journals. In 2019, the Japan Pharmaceutical Association searched for articles on this subject in domestic academic journals published over the past five years, and...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00174-5
- The Effect of Clinical Research by Community Pharmacists on the Medical
Field -The Perspective of Scientists in the Community Can Improve a
Patient's Circumstances
Authors: Michiyo Kawana
Abstract: Our pharmacy, with a sterile dispensary, is a support center for home-care dispensing; we are actively participating in a regional collaboration in combination with medical treatment, nursing, and social care. We have supported about 1000 home care patients so far: most of these have been elderly people living at home, but roughly two dozen were pediatric patients. Although the primary diseases of the children varied, they shared in common both a high dependence on medicine, and great difficulty...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00174-4
- Clinical Research in Communities and the Importance of Patient Information
Authors: Manabu Akazawa
Abstract: In collaboration with community pharmacists, we have conducted research including drug utilization reviews since 2009 and patient registry and long-term follow-up since 2013. The results of these projects have influenced the establishment of healthcare policies and pharmacists' roles. Moreover, the number of clinical studies using electronic medical records by hospital pharmacists has increased. Findings from real-world clinical practice provide useful evidence to improve the quality of patient...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00174-3
- Implementing Clinical Evidences into Community Pharmacies: Results of the
COMPASS and COMPASS-BP Studies
Authors: Hiroshi Okada
Abstract: Evidence-based medicine (EBM) has led to the development of evidence-based guidelines. The quality of guidelines has been improved by measuring their quality with The Appraisal of Guidelines for Research and Evaluation II (AGREE II) and Grading of Recommendations, Assessment, Development and Evaluation (GRADE). However, evidenced by guidelines not implemented in clinical practice or society, the evidence-practice gap has become apparent. The dissemination and implementation research, which...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00174-2
- Clinical Research in the Community-based Integrated Care System -from the
Perspective of Dissemination and Implementation Research
Authors: Taichi Shimazu
Abstract: There is a need for an effective and efficient way to incorporate and establish evidence-based interventions in daily healthcare. Dissemination and implementation (D&I) research seeks to obtain generalized knowledge to promote that. Implementation science methodologies can be used to scientifically analyze and generalize the themes previously consid-ered as D&I activities. In this article, the author introduces D&I research, and describes its current status and future perspective in Japan. The...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00174-1
- What Should Pharmacists Do through the Clinical Research, toward the
Community-based Integrated Care Systems' -From the Perspective of
Dissemination and Implementation Research
Authors: Miwako Kamei, Hiroshi Okada
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00174-F
- Homeostatic and Pathophysiological Regulation of Toll-like Receptor 4
Signaling by GM3 Ganglioside Molecular Species
Authors: Hirotaka Kanoh
Abstract: Chronic inflammation plays an important role in the pathogenesis of obesity and metabolic disorders. In obesity, pattern-recognition receptors in innate immune system, such as Toll-like receptor 4 (TLR4), cause chronic inflammation through prolonged activation by various endogenous ligands, including fatty acids and its metabolites. Gangliosides and other glycosphingolipids are important metabolites of fatty acids and saccharides. GM3, the simplest ganglioside comprising α2,3-sialyllactose, is...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-03-01
DOI: 10.1248/yakushi.21-00193
- Questionnaire Survey on Adoption and Prescription of Biosimilars (Antibody
and Its-related Products) by Medical Doctors in Japan
Authors: Yoshiko Aoki, Kimie Sai, Yukiko Katsuta, Mika Suzuki, Yasuo Suzuki, Akiko Ishii-Watabe, Yoshiro Saito
Abstract: Biosimilars are less expensive than their originators, and Japanese government policies call for their development and promotion. However, the adoption and prescription of some biosimilars, especially antibody/its-related ones, have been delayed for use in Japan, possibly due to concerns on the differences in quality attributes such as glycan structures between the originators and their biosimilars, and that clinical efficacy/safety studies are conducted for usually one disease and its results...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-02-24
DOI: 10.1248/yakushi.21-00216
- Synthetic Studies on Complex Natural Products Based on Development of a
Novel Synthetic Method for Heteroaromatic Skeleton
Authors: Juri Sakata
Abstract: Among my recent work on the syntheses of complex natural products based on the development of a novel synthetic method for the heteroaromatic skeleton, this article primarily deals with the total syntheses of (+)-CC-1065, isobatzeline A/B, and batzeline A. These syntheses were accomplished via a novel indole synthesis utilizing a ring expansion reaction of benzocyclobutenone oxime sulfonate as the key step. The 1,2-dihydro-3H-pyrrolo[3,2-e]indole segments of (+)-CC-1065 were rapidly constructed...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-02-03
DOI: 10.1248/yakushi.21-00199
- Suppurative Thrombophlebitis of the Posterior Neck Caused by Streptococcus
constellatus: A Case Report and Literature Review
Authors: Keisuke Takada, Mitsuchika Nakamura, Masaru Samura, Junki Inoue, Naoki Hirose, Takenori Kurata, Humio Nagumo, Junichi Ishii, Sakura Koshioka, Koji Tanikawa, Hiroyuki Kunishima
Abstract: We report a rare case of suppurative thrombophlebitis of the posterior neck caused by Streptococcus constellatus. A 69-year-old female patient was admitted to the hospital with neck pain and fever, which had persisted for 16 days prior to hospitalization. On day 1 (day of admission), blood cultures (later identifying S. constellatus) were performed, and ceftriaxone (CTRX) IV (2 g SID) was started. On day 3, suppurative thrombophlebitis of the posterior neck was diagnosed by CT scan. The...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-02-03
DOI: 10.1248/yakushi.21-00179
- Comparison in the Recognition about Medication Education between People
with Prelingual Hearing Loss and Pharmacists
Authors: Naomi Hyoguchi, Rikihisa Yoshida, Hidemi Ogura, Hirofumi Yamasaki, Taizou Tanaka, Toshio Kubota
Abstract: Providing medication information according to a patient's health literacy and communication ability is needed for safe and effective healthcare. Communication barriers due to hearing loss prevent pharmacists from providing medication information to patients with hearing loss. A questionnaire about the difficulty in understanding medication information and the feeling of inconvenience during medication education was conducted from September to October 2020 with 84 people with prelingual hearing...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-02-03
DOI: 10.1248/yakushi.21-00152
- Development of Bio-active Fullerene Derivatives Suitable for Drug
Authors: Tadahiko Mashino
Abstract: Fullerene (C(60)) and fullerene derivatives are attractive novel compounds not only for carbon materials of nanotechnology but also for medical fields because of its unique chemical and physical properties. We intend to develop fullerene derivatives as novel lead compounds for drug discovery. At first, we synthesized many types of water-soluble fullerene derivatives to investigate their biological activities because of their poor solubility in water. We found that anionic fullerene derivatives...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-02-03
DOI: 10.1248/yakushi.21-00188
- The New Generation of Particle Therapy Focused on Boron Element (Boron
Neutron Capture Therapy; BNCT) -The World's First Approved BNCT Drug
Authors: Hideki Nakashima
Abstract: Boron neutron capture therapy (BNCT) is a type of radiation therapy and a new modality for cancer treatment. The radiation used in BNCT is a very low energy neutron called a "thermal neutron", and unlike other radiation, it has no effect on treating cancer on its own. However, when this neutron collides with boron-10 (^(10)B), which is a stable isotope of boron, fission occurs into a high-energy helium nucleus (α-particle) and a lithium nucleus. Moreover, the effect of this fission reaction is...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-02-03
DOI: 10.1248/yakushi.21-00173-4
- Boronic Acid as a Promising Class of Chemical Entity for Development of
Clinical Medicine for Targeted Therapy of Cancer
Authors: Takumi Watanabe, Isao Momose
Abstract: The first medicine containing the boron element, bortezomib, was approved for clinical use just 18 years ago. The boronic acid substructure in bortezomib serves as an electrophilic functionality with high affinity for hydroxy groups, which are frequently found in catalytic sites of proteolytic enzymes, to create reversible covalent bonds with a slow dissociation rate. Today, boronic acid is considered an important molecule in the medicinal chemistry toolbox, which was promoted by the success of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-02-03
DOI: 10.1248/yakushi.21-00173-3
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