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- Evaluation of Disopyramide Efficacy for Refractory Syncope in Heart
Failure with Preserved Ejection Fraction Using Holter Electrocardiography:
A Case Report
Authors: Yuki Asai, Takuya Shintani, Takanori Yamamoto, Yoshiharu Sato
Abstract: The management of syncope is clinically important for heart failure (HF) patients. We herein describe a case on the efficacy of disopyramide for refractory syncope in HF with preserved ejection fraction (HFpEF). An 82-year-old man was hospitalized for respiratory distress and lower limb edema and was subsequently diagnosed with HFpEF. The use of diuretics improved HF symptoms; however, on day 10 after hospitalization, a rapid decrease in blood pressure and transient loss of consciousness...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00047
- A Survey of Illegal Medication Trading through Twitter in Japan
Authors: Hayase Hakariya, Tatsuki Ikejiri, Natsuki Yokoyama, Yoshiyuki Saito
Abstract: Non-medical use of prescription medications is a serious public health crisis. The black market for prescription medications should be routinely surveyed to encourage their appropriate use. Herein, we focused on Twitter to investigate the possibility of illicit drug trading in Japan. From March 1 to 8, 2021, we examined the characteristics of Twitter posts, identified using the search term "Okusuri Mogu Mogu", a Japanese argot used for trading of medications. The captured data included the date...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00048
- Two Cases at Community Pharmacies of Mercaptopurine Removal from a
Disk-type Powder-packaging Machine by Wiping It with Water
Authors: Wakana Yoshida, Sakae Saito, Magoichi Sako, Masamitsu Noda, Satoru Kawaguchi, Kazuya Arai, Saori Anzai, Satoshi Kubota, Kiyoshi Shibuya, Mitsuru Machida, Tadao Horino, Manahito Aoki, Katsuya Otori
Abstract: "Leukerin^(®) powder 10%" containing mercaptopurine (6-MP) is an oral anticancer drug that requires careful handling. As a powder formulation, there are risks of exposure due to scattering during dispensing and possible 6-MP contamination to other drugs due to adhesion to the packaging machine. We previously reported that wiping with an alcohol-containing towel is useful for removing scattered powder after dispensing. However, it is recommended to wipe disk-type powder-packaging machines with...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00045
- Improvement Method of Confirmation Test of the In-pharmacy Formulation as
Topical Medicine No. 37-①
Authors: Daisuke Teraoka, Miho Sakamoto, Kazue Tanaka, Yuki Saeki, Kiyoko Kishimoto, Machiko Nagashima, Toshinari Suzuki, Akiko Inomata, Takako Moriyasu
Abstract: Topical Medicine No. 37-① is one of the in-pharmacy formulation that specifies a confirmation test (referred hereafter as the conventional method) to identify its ingredient diphenhydramine (DH) by colorimetric test. However, the conventional method is environmentally unfriendly due to the large amount of sample and organic solvent used, and the extraction process is complicated. We therefore developed three methods in view of improving the currently confirmation testing process: a simplified...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00071
- Situations of Passive Smoking by Urine Cotinine Levels and Recognition of
Passive Smoking in High School Students -Effectiveness of Smoking
Prevention Education Using a Video Made by High School Students
Authors: Kenshi Takechi, Akari Kotegawa, Rino Sengoku, Yuto Nishizumi, Aina Yagawa, Masashi Wada, Naoto Motohashi, Shingo Takatori, Kazuhiko Shibata, Hiroyuki Nanba
Abstract: We investigated a situation of passive smoking and its damaging effects among high school students. Urine cotinine concentration was measured and quantified. Additionally, we evaluated the awareness of passive smoking and smoking regulations in high school students, and the educational effect on passive smoking using a questionnaire survey and educational videos produced by high school students. We conducted a self-reporting questionnaire survey with high school students before and after...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00070
- Investigation of Foreign Particles in Moderna COVID-19 Vaccine
Authors: Hiroko Shibata, Yusuke Nomura, Tsuyoshi Kawakami, Eiichi Yamamoto, Daisuke Ando, Nahoko Uchiyama, Hiroko Tokumoto, Tatsuo Koide, Hideyuki Sakoda, Hiroyuki Yoshida, Yasuhiro Abe, Takashi Hakamatsuka, Yoshiaki Ikarashi, Yuji Haishima, Akiko Ishii-Watabe, Ken-Ichi Izutsu, Masamitsu Honma, Yukihiro Goda
Abstract: Particular batches of Moderna mRNA Coronavirus Disease 2019 (COVID-19) vaccine were recalled after foreign particles were found in some vaccine vials at the vaccination site in Japan in August 2021. We investigated the foreign particles at the request of the Ministry of Health, Labour and Welfare. Energy dispersive X-ray spectroscopy analysis suggested that the foreign particles found in the vials recalled from the vaccination sites were from stainless steel SUS 316L, which was in line with the...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00067
- Brain Function and Pathophysiology Focused on Zn2+ Dynamics
Authors: Atsushi Takeda
Abstract: The basal levels of intracellular Zn^(2+) and extracellular Zn^(2+) are in the range of ～100 pM and ～10 nM, respectively, in the brain. Extracellular Zn^(2+) dynamics is involved in both cognitive performance and neurodegeneration. The bidirectional actions are linked with extracellular glutamate and amyloid-β(1-42) (Aβ(1-42)). Intracellular Zn^(2+) signaling via extracellular glutamate is required for learning and memory, while intracellular Zn^(2+) dysregulation induces cognitive decline....
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00074
- Introduction to Myelin Research
Authors: Hiroko Baba
Abstract: Myelin is a multilamellar membrane structure formed by oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS). It has been recognized as an insulator that is essential for the rapid and efficient propagation of action potentials by saltatory conduction. However, recently many studies have shown that myelin and myelin-forming cells interact with axons and regulate the nervous system far more actively than previously thought. For example,...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.21-00224
- Ideal Pharmaceutical Education Viewed from Quality Assurance on
Third-party Accreditation
Authors: Kazumasa Hirata
Abstract: The first-phase third-party accreditation conducted by the Japan Accreditation Board for Pharmaceutical Education between FY 2013 and 2019 revealed various issues regarding current pharmacy education programs. In addition, the report of the Ministry of Health, Labour and Welfare's Study Group on the Training and Quality Improvement of Pharmacists, which was published in 2021, identified a broad range of issues in pharmaceutical education related to pharmacist training and quality improvement....
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00004-4
- Ideal Thesis Research and Clinical Training as Pharmaceutical Practice in
6-year Pharmaceutical Education and Study System
Authors: Munetaka Kunishima
Abstract: Thesis research and clinical training are comprehensive areas of learning for cultivating the major abilities indicated in the professional competencies of the Model Core Curriculum for Pharmacy Education. They are also important subjects that can effectively reflect the educational philosophy and the human resource development policies of each university. In the School of Pharmacy and the School of Pharmaceutical Sciences at Kanazawa University, we have established a human resource development...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00004-3
- Reviewing the Model Core Curriculum for Pharmacy Education and Fundamental
Capacities to Become a Pharmacist with a 20-year Perspective on Human
Resources Development
Authors: Tadashi Suzuki
Abstract: The model core curriculum for pharmacy education (core curriculum) specifies the basics of 6-year pharmacy education. Pharmacy education is currently being provided based on the revised version of the core curriculum created in 2013 (revised core curriculum), with the aim of training pharmacists with the ability to fulfill social needs. The revised core curriculum also defines the "fundamental capacities to become a pharmacist" that should be acquired by the time of graduation. As education...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00004-2
- The Near Future of Pharmaceutical Education as Higher Education: Concepts
at the Heart of the Curriculum
Authors: Tsutomu Yamada
Abstract: Under the current Model Core Curriculum for Pharmaceutical Education, competencies and program-level learning outcomes are not differentiated; furthermore, how competencies are developed by specific behavioral objectives, which are subdivided by specialty, needs to be clarified. A clear vision for ensuring academic as well as clinical competencies in Japanese pharmaceutical education, which emphasizes research and education in basic fields, is needed. Standardization is necessary to ensure...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00004-1
- The Model Core Curriculum for Pharmacy Education to Become a Pharmacist
with a 20-year Perspective on Human Resources Development
Authors: Kazumasa Hirata, Tadashi Suzuki
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00004-F
- Physiological Function and Congenital Deficiency of α-TTP, a Determinant
of Vitamin E Transport in the Body -One Portion of the Research for Which
the Pharmaceutical Society of Japan Award Was Given
Authors: Hiroyuki Arai
Abstract: This review summarizes one portion of the research for which the author received the Pharmaceutical Society of Japan Award. The complete title of the awarded research is "Pharmacological Studies on Metabolism and Functions of Biomembrane Lipids". Because the awarded research is a very broad study, this review describes the discovery, physiological functions, and congenital defects of α-tocopherol transfer protein (α-TTP), a critical factor in determining the transport of vitamin E in the body,...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-31
DOI: 10.1248/yakushi.22-00090
- Constructs of the Collaboration between Hospital and Community
Pharmacists: Findings from Community Pharmacist Perspective Using
Multivariate Analysis and Structural Equation Modeling
Authors: Kenji Takahashi, Kengo Kojima, Rie Nakajima, Tatsuhiko Suzuki, Fumiyuki Watanabe
Abstract: Collaborations between hospital and community pharmacists play a key role in ensuring consistent continuation of pharmacotherapy within official medical care plans designed to promote community-based healthcare. A previous study conducted by the authors clarified the constructs of collaboration between the hospital and community pharmacists from the hospital pharmacist's perspective. In this study, a similar questionnaire was used to survey a group of pharmacies with 424 outlets nationwide, and...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-06
DOI: 10.1248/yakushi.22-00079
- A Pharmacist's Query Avoiding Exacerbation of Adverse Effects in a Patient
with Acyclovir Encephalopathy: A Case Report
Authors: Tatsuya Tai, Kazunori Yamaguchi, Naohiro Kurokawa, Wataru Shinmura, Aki Matsubara, Masahiro Watanabe, Takahiro Motoki, Hiroaki Tanaka, Hitoshi Houchi, Shinji Kosaka
Abstract: We report a haemodialysis patient with end-stage renal failure whom a pharmacist aided in the management of acyclovir (ACV) encephalopathy, which may have been related to valacyclovir hydrochloride (VACV) administered without sufficient dose reduction. The patient 78 years was admitted with a tentative diagnosis of varicella zoster viral meningitis. A pharmacist suspected ACV encephalopathy related to excessive VACV administration and raised a query with the attending physician. According to the...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00237
- Association between Post-marketing Safety-related Regulatory Actions and
Characteristics of New Drugs Approved in Japan between 2005 and 2016
Authors: Yuta Watanabe, Mamoru Narukawa
Abstract: The pharmacovigilance activities of new drugs are usually planned and conducted based on the clinical safety information obtained at approval. Revealing pre- and post-marketing drug characteristics associated with post-marketing safety-related regulatory actions (PSRAs) would help facilitate pharmacovigilance activities as these activities are not sufficient for early detection of safety signals that require warning. Therefore, we investigated the association between PSRAs and characteristics of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.22-00055
- Efficacy Survey of Naldemedine in the Poor-performance Status Group
Authors: Shintaro Kato, Yoshitaka Saito, Hiroko Onoda, Masayoshi Kumai, Shungo Imai, Kenkichi Tsuruga, Yoh Takekuma, Mitsuru Sugawara
Abstract: Naldemedine (Nal) is widely used as a therapeutic drug against opioid-induced constipation. However, patients in phase III trials are limited to those with good performance status (PS). Cancer patients may have inferior PS owing to progression of symptoms and adverse events from chemotherapy. Therefore, it is important to survey the efficacy of Nal in patients with poor PS. This study aimed to evaluate Nal efficacy in patients with poor PS. We retrospectively investigated patients from July 2017...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.22-00005
- Practice of Human Resource Development Related to Biopharmaceutical
Manufacturing and Quality Control and the International Contribution as
Centers of Excellence of Asia-Pacific Economic Cooperation-Life Sciences
Innovation Forum-Regulatory Harmonization Steering Committee
Authors: Kazuhisa Uchida
Abstract: In recent years, the development of biologics such as therapeutic antibodies has increased. Around 1980, Japan was the world's leading country in terms of research and development on biologics. However, after that, the development of biologics in Japan has become stagnant. Especially, research and development of therapeutic antibodies, which are critical medical products, is compared to that being conducted in Europe and the United States. The products distributed in Japan are developed and...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00211-4
- Points to Consider for Continuous Manufacturing of Biotechnological Drug
Products
Authors: Shinichi Okudaira
Abstract: Continuous Manufacturing is a manufacturing method in which raw materials enter the manufacturing process continuously, and products are discharged continuously throughout the duration of the process including multiple unit operations. Continuous Manufacturing includes various options: Those with all stages of processing from charging raw materials to discharging final products that are continuous, and those with only certain parts of the manufacturing process that are continuous. It can be...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00211-3
- Quality Evaluation of Therapeutic Antibodies by Multi-attribute Method
Authors: Noritaka Hashii, Michiko Tajiri, Akiko Ishii-Watabe
Abstract: In the development of therapeutic monoclonal antibodies (mAbs), it is essential to characterize the modifications causing structural heterogeneity because certain modifications are associated with safety and efficacy. However, the rapid structural analysis of mAbs remains challenging due to their structural complexity. The multi-attribute method (MAM) is a structural analytical method based on peptide mapping using LC/MS, and has drawn attention as a new quality control method for therapeutic...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00211-2
- Research and Development of Manufacturing of Biologics-the Activities of
Manufacturing Association of Biologics
Authors: Takeshi Omasa
Abstract: The industrial application of mammalian cells can be divided into two categories, where (1) the cells are mediators (i.e., the cell produces a desired product), or (2) the cells themselves are the product. The main application of cell-produced products is in biopharmaceuticals (biologics), and these include therapeutic enzymes, cytokines, antibodies, vaccines, and vectors for gene therapy. Among the 291 biopharmaceuticals launched in Europe and the United States by 2018, the number of products...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00211-1
- Technical Innovation of Manufacturing and Quality Control of Biologics to
Strengthen the Basis for New Biologics Development Leading to
International Contribution
Authors: Satoshi Toyoshima, Akiko Ishii-Watabe
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00211-F
- Introduction of "Access to Health" Initiatives for Neglected Tropical
Diseases (NTDs)～R&D of NTD Medicines～
Authors: Fumiya Domoto, Hiroyuki Kojima, Hiroaki Tasaki
Abstract: Astellas regards the situation where there still remain barriers for many people who have difficulty accessing the healthcare they need due to the lack of available treatments, poverty, healthcare system challenges and insufficient healthcare information. Astellas recognizes this problem as the Access to Health issue. To improve Access to Health, Astellas has identified four areas where we can leverage our strengths and technologies, and is working to solve issues, making full use of external...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00210-6
- Nucleic Acid-based Immuno-prophylaxis and -therapies against Tropical
Diseases
Authors: Ken J Ishii
Abstract: The number of clinical trials investigating the use of nucleic acid drugs, including DNA/RNA-based vaccines, immunostimulatory/modulatory DNA/RNA and cyclic dinucleotides, for immuno-prophylaxis and -therapy has been increasing exponentially in recent years. These new drugs have revealed their therapeutic potential not only as vaccines or adjuvant therapies, but also as monotherapies for use in immuno-therapy of cancer and allergic disease. I will present an overview of their current R&D taking...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00210-5
- A Strategic Partnership for Medicine Creation and Access to Medicine for
Neglected Tropical Diseases
Authors: Katsura Hata
Abstract: Neglected tropical diseases (NTDs) are communicable diseases that are uncommon in developed countries but epidemic in developing countries of the tropical and subtropical regions around the world. One of the important contributions expected of pharmaceutical companies is the development and provision of drugs effective against NTDs. Firstly, Eisai has distributed at price zero to endemic countries worldwide diethylcarbamazine (DEC) tablets for patients suffering with lymphatic filariasis (LF)....
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00210-4
- Partnership Activity for Neglected Tropical Diseases
Authors: Yuichiro Akao, Atsuko Ochida, Hiroya Muranishi, Izumi Nomura, Takashi Ichikawa
Abstract: Delivering new medicines to patients suffering from Neglected Tropical Diseases (NTD) is a major challenge. There are various hurdles to be overcome, such as the large number of patients in a large number of different regions, the lack of marketability, and resistance to medicines. Takeda Pharmaceutical Company Limited (Takeda) is following a corporate mission of "striving towards better health for patients worldwide though leading innovation in medicine". These guiding principles lead to the...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00210-3
- Corporate Efforts to Research and Develop Therapeutic Agents for
Infectious Diseases That Threaten Human
Authors: Ryu Yoshida, Rina Kaki, Osamu Yoshida, Takao Shishido, Teruhisa Kato, Yoshinori Yamano
Abstract: Overcoming serious infectious diseases such as malaria, tuberculosis, and other neglected tropical diseases (NTDs) that threaten human life around the world is an important issue in global health. Most of these diseases are concentrated in developing and low-income countries, and in order to reinforce drug discovery activities, pharmaceutical companies are actively promoting industry-academia-government partnerships and utilizing funds to stimulate global health activities. In this presentation,...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00210-2
- NTD Drug Discovery Booster, Achievements and Next Steps
Authors: Tatsuro Kuzuki, Benjamin Perry, Charles Mowbray
Abstract: The Neglected Tropical Disease (NTD) Drug Discovery Booster is a collaborative project in early small molecule drug discovery running since 2015 between Drugs for Neglected Diseases initiative (DNDi) and pharmaceutical partners across the globe, including Astellas Pharma Ltd., Eisai Co., Ltd., Shionogi & Co., Ltd. and Takeda Pharmaceutical Company Ltd. in Japan, along with AbbVie Inc., Merck KGaA, AstraZeneca plc and Celgene Corporation. The Booster engages these partners to share both their...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00210-1
- Recent Progress in Partnerships for NTD Drug Discovery in 2021
Authors: Haruki Yamada, Tomoyoshi Nozaki
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-07-05
DOI: 10.1248/yakushi.21-00210-F
- Identification of Three Arylcyclohexylamines (MXPr, MXiPr, and DMXE) in
Illegal Products
Authors: Rie Tanaka, Maiko Kawamura, Sakumi Mizutani, Takashi Hakamatsuka, Ruri Kikura-Hanajiri
Abstract: Arylcyclohexylamines are a category of substances to which the anesthetic ketamine belongs. The arylcyclohexylamines have been reported to act as antagonists of the N-methyl-d-aspartate (NMDA) receptor. An analog of ketamine, 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine; MXE), has been controlled as a narcotic in Japan and overdoses of MXE have been reported to cause health problems. In recent years, MXE derivatives have beendetected in illegal products in Japan. In this...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00235
- Development of an Online Role-play-based Medical Interview Training Method
for Fourth-year Pharmacy Students
Authors: Ayako Mori, Izumi Kato, Hitoshi Kashiwagi, Shungo Imai, Katsuya Narumi, Yuki Sato, Ayako Furugen, Yuma Yamada, Masaki Kobayashi
Abstract: With the coronavirus disease 2019 pandemic, businesses are rapidly expanding their online practices, and the online medical care system has been established and is growing. The field of pharmacy education is also looking for ways to conduct practical online training. Hence, we developed an online role-play-based medical interview training method for fourth-year pharmacy students. The purpose of this study was to describe in detail this method and to clarify the effect of online on medical...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00233
- Investigation and Improvement of Techniques That Affect the Amount of
Dispersal during Preparation of Anticancer Drugs
Authors: Yuki Yanagisawa, Kazuo Isama, Tomohiro Kurosu, Yoshiaki Natsume, Toshikazu Seino, Tetsuji Nishimura, Atsushi Yamashita
Abstract: Many healthcare workers who handle anticancer drugs are at risk for occupational exposure. However, there are no established permissible limits for occupational exposure to anticancer drugs; thus, in this study, we aimed to search for and improve procedures that have a greater impact on the amount of spatter for handling anticancer drugs in vials, which are frequently used, based on the quantitative evaluation of the amount of exposure. We used sodium riboflavin phosphate (FMN) as a simulated...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00172
- Analysis of Factors Affecting Proteinuria Onset Timing in Patients Treated
with Bevacizumab
Authors: Aya Murakami, Keisuke Noto, Ryosuke Ota, Atsushi Hirata
Abstract: Bevacizumab (BV) is a recombinant and humanized monoclonal antibody that inhibits vascular endothelial growth factor. BV is used to treat various types of cancer. Proteinuria is a characteristic adverse event that occurs as a result of treatment with BV. However, the onset timing of proteinuria after BV administration remains unclear. In the present study, we examined the risk factors affecting the timing of proteinuria onset upon BV administration. Medical records of 135 patients (62 males and...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00175
- Biologically Active Constituents of Natural Medicines -A Mixture Can Do
More
Authors: Fumiyuki Kiuchi
Abstract: Natural medicines, including crude drugs and Kampo prescriptions, have a long history of clinical uses. An important characteristic of natural medicines is that they are multicomponent medicines. Kampo prescriptions, particularly, usually consist of several crude drugs that contain a large number of constituents. The therapeutic effects of a Kampo prescription result from the total effects of its constituents and not from the effect of a representative constituent with a strong pharmacological...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.22-00013
- Development and Evaluation about "2nd-wave" COVID-19 Vaccines
Authors: Yasuhiro Araki
Abstract: To tackle the pandemic of the novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2), the international society, including Japan, has been actively promoting vaccination for SARS-CoV-2. To effectively utilize these vaccines, clinical trials have been conducted to evaluate their safety and efficacy. For efficacy evaluation, prevention rate of symptomatic novel coronavirus infections (corona virus disease 2019; COVID-19) between placebo groups and investigational vaccine...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00234-3
- What Is an Antibody Test' Characteristics of Antibodies against
SARS-CoV-2 and Their Tests
Authors: Akiko Ishii-Watabe
Abstract: Antibodies play a major role in immune responses against viruses, which inhibit infection by binding to target viral antigen. Antibodies are induced by viral entry to the body and vaccination that artificially induces immune responses; therefore, antibody tests are used in research for infection history and evaluation of vaccine efficacy. Currently, antibody tests against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by immunochromatography, enzyme-linked immunosorbent assay...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00234-2
- Compliance with Vaccination against SARS-CoV-2; Information Transmission
Based on Scientific Evidence and Its Difficulty
Authors: Itsuko Ishii
Abstract: The fight against coronavirus disease 2019 (COVID-19) in Japan began after January 2020. In order for the country to resume an active social life as a society, it is necessary to prevent an increase in the number of newly infected people with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), and to prevent aggravation and/or death after infection. Although several therapeutic agents have been developed to treat COVID-19 after infection, vaccination with SARS-CoV-2 is the most...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00234-1
- The Expert of the Medicine Explains "Understanding of the Novel
Coronavirus Vaccine"
Authors: Mariko Takeda-Morishita, Yoshinobu Takakura
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00234-F
- Promotion of Child Health and Development Care in Pharmacy Education
Authors: Kazuki Kushida, Masayoshi Hirohara
Abstract: Japan is simultaneously facing both an aging society and low birth rates, causing a continuing population decline. To cope with the declining birthrate, it is urgent to make child health and development medicine a natural accompaniment to all life stages. As pharmacists and pharmacies have a major role to play in this, it is necessary to position child health and development medicine in training for student pharmacists. On the other hand, student pharmacists are young adults who may be directly...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00198-5
- Support and Challenges for Adolescent and Young Adult Cancer Patients
Authors: Hiroshi Sakurashita
Abstract: The current adolescent and young adult (AYA) generation represents a unique age group, among whom life changes dramatically due to living environments including school, seeking employment, marriage, and pregnancy, and due to lack of a social support system for cancer during the AYA years. The 3rd term of the Basic Plan for Cancer Control Promotion has stimulated increased momentum toward medical community involvement with AYA generation cancer patients, leading to the establishment of a...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00198-4
- Survey on the Provision of Drug Information by Pharmacists to Lactating
Women
Authors: Seiko Miyazaki
Abstract: Many lactating women want to breastfeed their baby, but may be overly concerned regarding the drugs present in breast milk; this leads to unnecessary weaning. Moreover, lactating women may stop taking medications at their own discretion and may not receive adequate treatment. Therefore, pharmacists are required to provide appropriate information to lactating women. In 2020, we conducted a questionnaire survey on 1781 pharmacists with the aim of investigating the actual situation of the provision...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00198-3
- The Role of Pharmacists as Seen from the Japan Teratology Information
Center
Authors: Atsuko Murashima
Abstract: The Japan Drug Information Institute in Pregnancy (JDIIP) was established in 2005 as a project of the Ministry of Health, Labour and Welfare with the aims of providing information on drug safety to women who are worried about drug use during pregnancy and creating evidence through epidemiological studies based on counseling cases. Since being established, JDIIP has made many contributions to the wellness of mothers and children by promoting the proper use of drugs during pregnancy. However, some...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00198-2
- Health and Disease Management for Women's Life Stages: As Family
Pharmacists and Leaders of Health Support Pharmacies
Authors: Fujiko Miyahara
Abstract: The number of women in the workforce is increasing because promoting their participation has become part of the country's growth strategy. On the other hand, maintaining the population is also a major issue. It is necessary to consider what kind of education should be provided to trainee pharmacists as people who are personally involved, and what kind of education is necessary for them as future medical professionals. The Basic Law for Child and Maternal Health and Child Development has been...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00198-1
- To Advance Child Health and Development through Innovative Pharmacy
Education
Authors: Kazuki Kushida, Hiroko Unei
Abstract: No abstract
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.21-00198-F
- Total Synthesis and Functional Analysis of Complex Peptidic Natural
Products and Their Artificial Analogues
Authors: Hiroaki Itoh
Abstract: This review focuses on a new solid-phase synthetic strategy for an anticancer natural product yaku'amide B (1) and its target identification and structure-function relationship study using synthetic analogues and probes. To realize the Fmoc-based solid-phase synthesis of 1, we developed new synthetic methods for enamide formation. Namely, modified traceless Staudinger ligation using alkenyl azides and newly designed phosphinophenol esters enabled stereoselective construction of the (E)- and...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-06-01
DOI: 10.1248/yakushi.22-00042
- Impact of the Antimicrobial Stewardship Team Intervention Focusing on
Changes in Prescribing Trends and the Rate of Carbapenem-resistant P.
aeruginosa
Authors: Yuika Naito, Masayuki Maeda, Yasuhiro Nagatomo, Kazuhisa Ugajin, Etsuko Akima, Michiko Tanaka, Issei Tokimatsu, Tadanori Sasaki
Abstract: Antimicrobial stewardship (AS) intervention strategy is a critical process in promoting appropriate antibiotic use, thus preventing unnecessarily prolonged therapy and reducing antimicrobial resistance (AMR). Although limiting unnecessary carbapenem use by AS intervention is speculated to reduce AMR, there is a lack of specific data on the efficacy of AS team (AST) intervention regarding carbapenem-resistant Pseudomonas aeruginosa (CRPA). Consequently, this study aimed to evaluate the impact of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00202
- Pharmacological Cognitive Enhancement: Current Situation and Perspectives
Authors: Midori Yamamoto
Abstract: Pharmacological cognitive enhancement (PCE) refers to the use of biochemical enhancers for achieving improved mental performance in healthy individuals. One particular use of PCE prevalence is the misuse of these enhancers among university students for academic performance enhancement. The prevalence rates demonstrate the use of a broad spectrum of substances for PCE that can be classified as OTC, prescription, and illegal drugs. Given that certain substances have been widely used for years,...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00195
- Photopharmacological Tools for Mitotic Cell Division
Authors: Kazuya Matsuo
Abstract: Genetic information is replicated and transmitted from a parent cell to two identical daughter cells through mitotic cell division. To accomplish this dynamic process with high accuracy and precision, various motor proteins work in a concerted manner. Especially in the metaphase, mitotic chromosomes are delivered by the motor protein of centromere-associated protein E (CENP-E) to the cell equatorial plane (metaphase plate) along mitotic spindles. However, the critical functional failure of...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00203-5
- Development of Photoresponsive Probes to Investigate Cellular Functions
Authors: Shin Mizukami
Abstract: Technologies for the optical control of biomolecular functions have recently attracted considerable attention because they can be combined with advanced laser and microscopic techniques for diverse applications at the cellular and intravital levels. In this account, I review the summary of optical control technologies for biomolecular functions based on organic chemistry or protein science, and then introduce our recent studies on the development of small molecule-based photoregulation...
Citation: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
PubDate: 2022-05-01
DOI: 10.1248/yakushi.21-00203-4
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