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- Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to
promote PD-L1 multivalent binding for effective immune checkpoint blockade
therapy
Abstract: Publication date: Available online 19 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Youngjoo Lee, Sukyung Song, Suah Yang, Jinseong Kim, Yujeong Moon, Nayeon Shim, Hong Yeol Yoon, Sehoon Kim, Man Kyu Shim, Kwangmeyung Kim
- Disulfide bridge-targeted metabolome mining unravels an antiparkinsonian
peptide
Abstract: Publication date: Available online 19 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Zhiwu Tong, Xiahong Xie, Huiming Ge, Ruihua Jiao, Tingting Wang, Xincun Wang, Wenying Zhuang, Gang Hu, Renxiang Tan
- TBC1D15 deficiency protects against doxorubicin cardiotoxicity via
inhibiting DNA-PKcs cytosolic retention and DNA damage
Abstract: Publication date: Available online 17 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Wenjun Yu, Haixia Xu, Zhe Sun, Yuxin Du, Shiqun Sun, Miyesaier Abudureyimu, Mengjiao Zhang, Jun Tao, Junbo Ge, Jun Ren, Yingmei Zhang
- ACAT1 deficiency in myeloid cells promotes glioblastoma progression by
enhancing accumulation of myeloid-derived suppressors cells metabolism
Abstract: Publication date: Available online 15 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Mingjin Wang, Weida Wang, Shen You, Zhenyan Hou, Ming Ji, Nina Xue, Tingting Du, Xiaoguang Chen, Jing Jin
- Metabolic basis of solute carrier transporters in treatment of type 2
diabetes mellitus
Abstract: Publication date: Available online 15 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Jiamei Le, Yilong Chen, Wei Yang, Ligong Chen, Jianping Ye
- Overview of epigenetic degraders based on PROTAC, molecular glue, and
hydrophobic tagging technologies
Abstract: Publication date: Available online 12 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Xiaopeng Peng, Zhihao Hu, Limei Zeng, Meizhu Zhang, Congcong Xu, Benyan Lu, Chengpeng Tao, Weiming Chen, Wen Hou, Kui Cheng, Huichang Bi, Wanyi Pan, Jianjun Chen
- Cancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that
modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrence
Abstract: Publication date: Available online 9 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Ju Chen, Bhaskara Reddy Madina, Elham Ahmadi, Timur Olegovich Yarovinsky, Marie Marthe Krady, Eileen Victoria Meehan, Isabella China Wang, Xiaoyang Ye, Elise Pitmon, Xian-Yong Ma, Bijan Almassian, Valerian Nakaar, Kepeng Wang
- Identification of a natural PLA2 inhibitor from the marine fungus
Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by
inhibiting the IRE-1α/XBP-1s axis and JNK signaling
Abstract: Publication date: Available online 9 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Yong Rao, Rui Su, Chenyan Wu, Xingxing Chai, Jinjian Li, Guanyu Yang, Junjie Wu, Tingting Fu, Zhongping Jiang, Zhikai Guo, Congjun Xu, Ling Huang
- pH-Responsive polymer boosts cytosolic siRNA release for retinal
neovascularization therapy
Abstract: Publication date: Available online 9 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Shuai Guo, Chunhui Li, Changrong Wang, Xiaowen Cao, Xinyue Liu, Xing-Jie Liang, Yuanyu Huang, Yuhua Weng
- Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE
inhibitor against drug-resistant bacterial infection
Abstract: Publication date: Available online 9 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Xintong Zhao, Jing Feng, Jie Zhang, Zunsheng Han, Yuhua Hu, Hui-Hui Shao, Tianlei Li, Jie Xia, Kangfan Lei, Weiping Wang, Fangfang Lai, Yuan Lin, Bo Liu, Kun Zhang, Chi Zhang, Qingyun Yang, Xinyu Luo, Hanyilan Zhang, Chuang Li, Wenxuan Zhang
- Author correction to ‘Tumor-microenvironment activated duplex
genome-editing nanoprodrug for sensitized near-infrared titania
phototherapy’ [Acta Pharm Sin B 13 (2022) 4224-4234]
Abstract: Publication date: Available online 7 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Zekun Li, Yongchun Pan, Shiyu Du, Yayao Li, Chao Chen, Hongxiu Song, Yueyao Wu, Xiaowei Luan, Qin Xu, Xiaoxiang Guan, Yujun Song, Xin Han
- Boosting synergism of chemo- and immuno-therapies via switching
paclitaxel-induced apoptosis to mevalonate metabolism-triggered
ferroptosis by bisphosphonate coordination lipid nanogranules
Abstract: Publication date: Available online 4 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Ge Song, Minghui Li, Shumin Fan, Mengmeng Qin, Bin Shao, Wenbing Dai, Hua Zhang, Xueqing Wang, Bing He, Qiang Zhang
- Metal nanoparticles for cancer therapy: Precision targeting of DNA damage
Abstract: Publication date: Available online 3 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Qian Chen, Chunyan Fang, Fan Xia, Qiyue Wang, Fangyuan Li, Daishun Ling
- Plant-derived nanovesicles as an emerging platform for cancer therapy
Abstract: Publication date: Available online 3 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Hanzhe Liu, Guo-Feng Luo, Zhengjun Shang
- Author correction to ‘Amino-functionalized poloxamer 407 with both
mucoadhesive and thermosensitive properties: Preparation, characterization
and application in vaginal drug delivery system’ [Acta Pharm Sin B 7
(2017) 593–602]
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Li-qian Ci, Zhi-gang Huang, Yu Liu, Zhe-peng Liu, Gang Wei, Wei-yue Lu
- Author correction to ‘TMEM16A inhibits angiotensin II-induced basilar
artery smooth muscle cell migration in a WNK1-dependent manner’ [Acta
Pharmaceutica Sinica B 11 (2021) 3994–4007]
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Huaqing Zheng, Xiaolong Li, Xin Zeng, Chengcui Huang, Mingming Ma, Xiaofei Lv, Yajuan Zhang, Lu Sun, Guanlei Wang, Yanhua Du, Yongyuan Guan
- Antitumor synergism between PAK4 silencing and immunogenic phototherapy of
engineered extracellular vesicles
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Mei Lu, Haonan Xing, Wanxuan Shao, Pengfei Wu, Yuchuan Fan, Huining He, Stefan Barth, Aiping Zheng, Xing-Jie Liang, Yuanyu Huang
- Aureane-type sesquiterpene tetraketides as a novel class of
immunomodulators with interleukin-17A inhibitory activity
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Xin Tang, Chuanxi Wang, Lei Wang, Feifei Ren, Runqiao Kuang, Zhenhua Li, Xue Han, Yiming Chen, Guodong Chen, Xiuqing Wu, Jie Liu, Hengwen Yang, Xingzhong Liu, Chen Wang, Hao Gao, Zhinan Yin
- Characterization of the depsidone gene cluster reveals etherification,
decarboxylation and multiple halogenations as tailoring steps in depsidone
assembly
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Jiafan Yang, Zhenbin Zhou, Yingying Chen, Yongxiang Song, Jianhua Ju
- Amelioration of ethanol-induced oxidative stress and alcoholic liver
disease by in vivo RNAi targeting Cyp2e1
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Yalan Wang, Qiubing Chen, Shuang Wu, Xinyu Sun, Runting Yin, Zhen Ouyang, Hao Yin, Yuan Wei
- Orchestrating antigen delivery and presentation efficiency in lymph node
by nanoparticle shape for immune response
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Hongjuan Zhao, Yatong Li, Beibei Zhao, Cuixia Zheng, Mengya Niu, Qingling Song, Xinxin Liu, Qianhua Feng, Zhenzhong Zhang, Lei Wang
- Disease-specific protein corona formed in pathological intestine enhances
the oral absorption of nanoparticles
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Jiawei Wu, Liyun Xing, Yaxian Zheng, Yinglan Yu, Ruinan Wu, Xi Liu, Lian Li, Yuan Huang
- Bladder microenvironment actuated proteomotors with ammonia amplification
for enhanced cancer treatment
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Hao Tian, Juanfeng Ou, Yong Wang, Jia Sun, Junbin Gao, Yicheng Ye, Ruotian Zhang, Bin Chen, Fei Wang, Weichang Huang, Huaan Li, Lu Liu, Chuxiao Shao, Zhili Xu, Fei Peng, Yingfeng Tu
- Self-assembly of CXCR4 antagonist peptide–docetaxel conjugates for
breast tumor multi-organ metastasis inhibition
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Chen Li, Jiayan Lang, Yazhou Wang, Zhaoxia Cheng, Mali Zu, Fenfen Li, Jingyi Sun, Yating Deng, Tianjiao Ji, Guangjun Nie, Ying Zhao
- Brain endothelial cell-derived extracellular vesicles with a
mitochondria-targeting photosensitizer effectively treat glioblastoma by
hijacking the blood‒brain barrier
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Thuy Giang Nguyen Cao, Ji Hee Kang, Su Jin Kang, Quan Truong Hoang, Han Chang Kang, Won Jong Rhee, Yu Shrike Zhang, Young Tag Ko, Min Suk Shim
- LPS adsorption and inflammation alleviation by polymyxin B-modified
liposomes for atherosclerosis treatment
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Huiwen Liu, Honglan Wang, Qiyu Li, Yiwei Wang, Ying He, Xuejing Li, Chunyan Sun, Onder Ergonul, Füsun Can, Zhiqing Pang, Bo Zhang, Yu Hu
- Functional annotation map of natural compounds in traditional Chinese
medicines library: TCMs with myocardial protection as a case
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Xudong Xing, Mengru Sun, Zifan Guo, Yongjuan Zhao, Yuru Cai, Ping Zhou, Huiying Wang, Wen Gao, Ping Li, Hua Yang
- Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist
reversing macrophage polarization and neutrophil infiltration against
acute inflammation
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Junjie Yang, Yue Pan, Xiaoshan Zeng, Shuwen Liu, Zhipeng Chen, Kui Cheng
- Discovery of an orally effective double-stapled peptide for reducing
ovariectomy-induced bone loss in mice
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Wei Cong, Huaxing Shen, Xiufei Liao, Mengjun Zheng, Xianglong Kong, Zhe Wang, Si Chen, Yulei Li, Honggang Hu, Xiang Li
- Gastrin attenuates sepsis-induced myocardial dysfunction by
down-regulation of TLR4 expression in macrophages
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Dandong Fang, Yu Li, Bo He, Daqian Gu, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Ming Tang, Xingbing Li, Donghai Yang, Chunmei Xu, Yijie Hu, Hongyong Wang, Pedro A. Jose, Yu Han, Chunyu Zeng
- Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity
to trigger Ca2+
ER perturbation in hepatocellular carcinoma
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Yanan Li, Keqin Li, Ting Pan, Qiaobo Xie, Yuyao Cheng, Xinfeng Wu, Rui Xu, Xiaohui Liu, Li Liu, Jiangming Gao, Wenmin Yuan, Xianjun Qu, Shuxiang Cui
- Hepatic retinaldehyde deficiency is involved in diabetes deterioration by
enhancing PCK1- and G6PC-mediated gluconeogenesis
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Hanyu Yang, Mengxiang Su, Ming Liu, Yun Sheng, Liang Zhu, Lu Yang, Ruijing Mu, Jianjun Zou, Xiaodong Liu, Li Liu
- Gestational dexamethasone exposure impacts hippocampal excitatory synaptic
transmission and learning and memory function with transgenerational
effects
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Mingcui Luo, Yiwen Yi, Songqiang Huang, Shiyun Dai, Lulu Xie, Kexin Liu, Shuai Zhang, Tao Jiang, Tingting Wang, Baozhen Yao, Hui Wang, Dan Xu
- Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Chen Hu, Lijuan Shen, Fengming Zou, Yun Wu, Beilei Wang, Aoli Wang, Chao Wu, Li Wang, Jing Liu, Wenchao Wang, Qingsong Liu
- Polymyxin resistance caused by large-scale genomic inversion due to IS26
intramolecular translocation in Klebsiella pneumoniae
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Haibin Li, Lang Sun, Han Qiao, Zongti Sun, Penghe Wang, Chunyang Xie, Xinxin Hu, Tongying Nie, Xinyi Yang, Guoqing Li, Youwen Zhang, Xiukun Wang, Zhuorong Li, Jiandong Jiang, Congran Li, Xuefu You
- Research advances in peptide‒drug conjugates
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Liming Gong, Heming Zhao, Yanhong Liu, Hao Wu, Chao Liu, Shuangyan Chang, Liqing Chen, Mingji Jin, Qiming Wang, Zhonggao Gao, Wei Huang
- Regulating the microenvironment with nanomaterials: Potential strategies
to ameliorate COVID-19
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Zhicheng Liu, Zhuolei Han, Xin Jin, Jusung An, Jaewon Kim, Wenting Chen, Jong Seung Kim, Ji Zheng, Jun Deng
- Potential herb–drug interactions between anti-COVID-19 drugs and
traditional Chinese medicine
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Ling Ye, Shicheng Fan, Pengfei Zhao, Chenghua Wu, Menghua Liu, Shuang Hu, Peng Wang, Hongyu Wang, Huichang Bi
- Bispecific antibodies in cancer therapy: Target selection and regulatory
requirements
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s): Yanze Sun, Xinmiao Yu, Xiao Wang, Kai Yuan, Gefei Wang, Lingrong Hu, Guoyu Zhang, Wenli Pei, Liping Wang, Chengliang Sun, Peng Yang
- Cover Story
Abstract: Publication date: September 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 9Author(s):
- Unlocking the potential of amorphous calcium carbonate: A star ascending
in the realm of biomedical application
Abstract: Publication date: Available online 1 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Han Liu, Zhiyang Wen, Zihan Liu, Yanfang Yang, Hongliang Wang, Xuejun Xia, Jun Ye, Yuling Liu
- Converting bacteria into autologous tumor vaccine via surface
biomineralization of calcium carbonate for enhanced immunotherapy
Abstract: Publication date: Available online 1 September 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Lina Guo, Jinsong Ding, Wenhu Zhou
- Author correction to ‘Cascade Two-stage Tumor Re-oxygenation and Immune
Re-sensitization Mediated by Self-Assembled Albumin-Sorafenib
Nanoparticles for Enhanced Photodynamic Immunotherapy’ [Acta
Pharmaceutica Sinica B 2022;12(11):4204-4223]
Abstract: Publication date: Available online 31 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Zaigang Zhou, Jiashe Chen, Yu Liu, Chunjuan Zheng, Wenjuan Luo, Lele Chen, Shen Zhou, Zhiming Li, Jianliang Shen
- Genomics-driven derivatization of the bioactive fungal sesterterpenoid
variecolin: Creation of an unnatural analogue with improved anticancer
properties
Abstract: Publication date: Available online 30 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Dexiu Yan, Jemma Arakelyan, Teng Wan, Ritvik Raina, Tsz Ki Chan, Dohyun Ahn, Vladimir Kushnarev, Tsz Kiu Cheung, Ho Ching Chan, Inseo Choi, Pui Yi Ho, Feijun Hu, Yujeong Kim, Hill Lam Lau, Ying Lo Law, Chi Seng Leung, Chun Yin Tong, Kai Kap Wong, Wing Lam Yim, Nikolay S. Karnaukhov
- Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly
attenuated vesicular stomatitis virus vector (VSVMT) in golden syrian
hamster
Abstract: Publication date: Available online 25 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Yong Ke, En Zhang, Jianming Guo, Xiaoxiao Zhang, Lei Wang, Duo Chen, Xinkui Fang, Jianwei Zhu, Feng Li, Tao Sun, Baohong Zhang
- Emerging delivery systems based on aqueous two-phase systems: A review
Abstract: Publication date: Available online 24 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Yaowen Zhang, Yankun Luo, Jingqi Zhao, Wenzhuo Zheng, Jun Zhan, Huaping Zheng, Feng Luo
- Mitochondria-specific near-infrared photoactivation of peroxynitrite
upconversion luminescent nanogenerator for precision cancer gas therapy
Abstract: Publication date: Available online 22 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Hui Yu, Aliya Tiemuer, Xufeng Yao, Mingyuan Zuo, Hai-Yan Wang, Yi Liu, Xiaoyuan Chen
- Development of exosome membrane materials-fused microbubbles for enhanced
stability and efficient drug delivery of ultrasound contrast agent
Abstract: Publication date: Available online 19 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Yongho Jang, Jeehun Park, Pilsu Kim, Eun-Joo Park, Hyungjin Sun, Yujin Baek, Jaehun Jung, Tai-kyong Song, Junsang Doh, Hyuncheol Kim
- Remodeling of the liver fibrosis microenvironment based on
nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic
activity
Abstract: Publication date: Available online 19 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Huaqing Jing, Yingzi Ren, Yue Zhou, Min Xu, Sona Krizkova, Zbynek Heger, Qiang Lu, Siyu Wang, Xiaoyang Liang, Vojtech Adam, Nan Li
- Immunostimulatory gene therapy combined with checkpoint blockade reshapes
tumor microenvironment and enhances ovarian cancer immunotherapy
Abstract: Publication date: Available online 19 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Yunzhu Lin, Xiang Wang, Shi He, Zhongxin Duan, Yunchu Zhang, Xiaodong Sun, Yuzhu Hu, Yuanyuan Zhang, Zhiyong Qian, Xiang Gao, Zhirong Zhang
- Cancer cell membrane-coated bacterial ghosts for highly efficient
paclitaxel delivery against metastatic lung cancer
Abstract: Publication date: Available online 19 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Dandan Ling, Xueli Jia, Ke Wang, Qiucheng Yan, Bochuan Yuan, Lina Du, Miao Li, Yiguang Jin
- Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for
cardiac ischemic injury via modulation of local immunity and cardiac
regeneration
Abstract: Publication date: Available online 19 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Qiaozi Wang, Yanan Song, Jinfeng Gao, Qiyu Li, Jing Chen, Yifang Xie, Zhengmin Wang, Haipeng Tan, Hongbo Yang, Ning Zhang, Juying Qian, Zhiqing Pang, Zheyong Huang, Junbo Ge
- Author correction to ‘Real-time SERS monitoring anticancer drug release
along with SERS/MR imaging for pHsensitive chemo-phototherapy’ [Acta
Pharm Sin B 2023;13(3):1303-1317]
Abstract: Publication date: Available online 18 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Xueqin Huang, Bingbing Sheng, Hemi Tian, Qiuxia Chen, Yingqi Yang, Brian Bui, Jiang Pi, Huaihong Cai, Shanze Chen, Jianglin Zhang, Wei Chen, Haibo Zhou, Pinghua Sun
- Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via
regulation of TFRC-dependent ferroptosis
Abstract: Publication date: Available online 18 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Wenjing Yu, Yuehuai Hu, Zhiping Liu, Kaiteng Guo, Dinghu Ma, Mingxia Peng, Yuemei Wang, Jing Zhang, Xiaolei Zhang, Panxia Wang, Jiguo Zhang, Peiqing Liu, Jing Lu
- Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for
alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS
signalling
Abstract: Publication date: Available online 18 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Xin Zhuo, Yue Wu, Xiujuan Fu, Jianbin Li, Yuxin Xiang, Xiaoyu Liang, Canquan Mao, Yuhong Jiang
- Translating bacteriophage-derived depolymerases into antibacterial
therapeutics: Challenges and prospects
Abstract: Publication date: Available online 18 August 2023Source: Acta Pharmaceutica Sinica BAuthor(s): Honglan Wang, Yannan Liu, Changqing Bai, Sharon Shui Yee Leung
- Author correction to ‘Approved HIV reverse transcriptase inhibitors in
the past decade’ [Acta Pharmaceutica Sinica B 12 (2022) 1567–1590]
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Guangdi Li, Yali Wang, Erik De Clercq
- Author correction to ‘Protective effects of VMY-2-95 on
corticosterone-induced injuries in mice and cellular models’ [Acta
Pharmaceutica Sinica B 11 (2021) 1903–1913]
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Ziru Yu, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du
- Author correction to ‘Bioengineered miR-124-3p prodrug selectively
alters the proteome of human carcinoma cells to control multiple cellular
components and lung metastasis in vivo’ [Acta Pharmaceutica Sinica B 11
(2021) 3950–3965]
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Linglong Deng, Hannah Petrek, Mei-Juan Tu, Neelu Batra, Ai-Xi Yu, Ai-Ming Yu
- Author correction to ‘Herbal formula BaWeiBaiDuSan alleviates
polymicrobial sepsis-induced liver injury via increasing the gut
microbiota Lactobacillus johnsonii and regulating macrophage
anti-inflammatory activity in mice’ [Acta Pharmaceutica Sinica B 13
(2023) 1164–1179]
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Xiaoqing Fan, Chutian Mai, Ling Zuo, Jumin Huang, Chun Xie, Zebo Jiang, Runze Li, Xiaojun Yao, Xingxing Fan, Qibiao Wu, Peiyu Yan, Liang Liu, Jianxin Chen, Ying Xie, Elaine Lai-Han Leung
- P450-mediated dehydrotyrosine formation during WS9326 biosynthesis
proceeds via dehydrogenation of a specific acylated dipeptide substrate
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Songya Zhang, Lin Zhang, Anja Greule, Julien Tailhades, Edward Marschall, Panward Prasongpholchai, Daniel J. Leng, Jingfan Zhang, Jing Zhu, Joe A. Kaczmarski, Ralf B. Schittenhelm, Oliver Einsle, Colin J. Jackson, Fabrizio Alberti, Andreas Bechthold, Youming Zhang, Manuela Tosin, Tong Si, Max J. Cryle
- Schisandra lignans ameliorate nonalcoholic steatohepatitis by regulating
aberrant metabolism of phosphatidylethanolamines
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Lijuan Xue, Keanqi Liu, Caixia Yan, Junling Dun, Yexin Xu, Linlin Wu, Huizhu Yang, Huafang Liu, Lin Xie, Guangji Wang, Yan Liang
- A highly selective C-rhamnosyltransferase from Viola tricolor and insights
into its mechanisms
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Bo-Yun Han, Zi-Long Wang, Junhao Li, Qing Jin, Hao-Tian Wang, Kuan Chen, Yang Yi, Hans Ågren, Xue Qiao, Min Ye
- An antigen self-assembled and dendritic cell-targeted nanovaccine for
enhanced immunity against cancer
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Yunting Zhang, Min Jiang, Guangsheng Du, Xiaofang Zhong, Chunting He, Ming Qin, Yingying Hou, Rong Liu, Xun Sun
- Improving cancer immunotherapy via co-delivering checkpoint blockade and
thrombospondin-1 downregulator
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Qingqing Xiao, Xiaotong Li, Chang Liu, Yuxin Jiang, Yonglong He, Wanting Zhang, Helena S. Azevedo, Wei Wu, Yuanzheng Xia, Wei He
- Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1
ubiquitination and suppress breast cancer growth and metastasis
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Ke Yang, Lei Xu, Ying Xu, Qian Shen, Tao Qin, Yunfang Yu, Yan Nie, Herui Yao, Xiaoding Xu
- Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized
photothermal therapy of breast cancer and brain metastases through
inhibiting stress granule formation and reprogramming tumor‐associated
macrophages
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Fan Tong, Haili Hu, Yanyan Xu, Yang Zhou, Rou Xie, Ting Lei, Yufan Du, Wenqin Yang, Siqin He, Yuan Huang, Tao Gong, Huile Gao
- Rapidly separating dissolving microneedles with sustained-release
colchicine and stabilized uricase for simplified long-term gout management
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Yao Yang, Zimu Li, Ping Huang, Jiachan Lin, Jinyuan Li, Kexin Shi, Jiahui Lin, Jingwen Hu, Zhuoxian Zhao, Yongkang Yu, Hongzhong Chen, Xiaowei Zeng, Lin Mei
- Full-profile pharmacokinetics, anticancer activity and toxicity of an
extended release trivalent PEGylated irinotecan prodrug
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Shiwen Song, Dong Sun, Hong Wang, Jinliang Wang, Huijing Yan, Xuan Zhao, John Paul Fawcett, Xin Xu, Deqi Cai, Jingkai Gu
- Versatile flexible micelles integrating mucosal penetration and intestinal
targeting for effectively oral delivery of paclitaxel
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Chao Liu, Wei Liu, Yanhong Liu, Hongxia Duan, Liqing Chen, Xintong Zhang, Mingji Jin, Minhu Cui, Xiuquan Quan, Libin Pan, Jiachun Hu, Zhonggao Gao, Yan Wang, Wei Huang
- A new class of potent liver injury protective compounds: Structural
elucidation, total synthesis and bioactivity study
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Kailong Ji, Wei Liu, Weihang Yin, Xiangrong Kong, Honghong Xu, Zeng-Wei Lai, Jing-Ya Li, Jian-Min Yue
- Dissecting the novel abilities of aripiprazole: The generation of
anti-colorectal cancer effects by targeting Gαq via HTR2B
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Haowei Liu, Qiuming Huang, Yunqi Fan, Bo Li, Xuemei Liu, Changhua Hu
- Pharmacological inhibition of BAP1 recruits HERC2 to competitively
dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to
radiotherapy
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Xin Yue, Tingyu Liu, Xuecen Wang, Weijian Wu, Gesi Wen, Yang Yi, Jiaxin Wu, Ziyang Wang, Weixiang Zhan, Ruirui Wu, Yuan Meng, Zhirui Cao, Liyuan Le, Wenyan Qiu, Xiaoyue Zhang, Zhenyu Li, Yong Chen, Guohui Wan, Xianzhang Bu, Zhenwei Peng
- Potentiation of PIEZO2 mechanically-activated currents in sensory neurons
mediates vincristine-induced mechanical hypersensitivity
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Mingli Duan, Yurui Jia, Lifang Huo, Yiting Gao, Jia Wang, Wei Zhang, Zhanfeng Jia
- Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese
mice: Involvement of reduced S100A11 expression
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Xiyue Shen, Kai Luo, Juntao Yuan, Junling Gao, Bingqing Cui, Zhuoran Yu, Zhongbing Lu
- HR121 targeting HR2 domain in S2 subunit of spike protein can serve as a
broad-spectrum SARS-CoV-2 inhibitor via intranasal administration
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Ying Lu, Fan Shen, Wen-Qiang He, An-Qi Li, Ming-Hua Li, Xiao-Li Feng, Yong-Tang Zheng, Wei Pang
- Advanced subunit vaccine delivery technologies: From vaccine cascade
obstacles to design strategies
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Yingying Hou, Min Chen, Yuan Bian, Xi Zheng, Rongsheng Tong, Xun Sun
- Plant-derived nanovesicles: Further exploration of biomedical function and
application potential
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Aixue Li, Dan Li, Yongwei Gu, Rongmei Liu, Xiaomeng Tang, Yunan Zhao, Fu Qi, Jifu Wei, Jiyong Liu
- Microfluidics for nano-drug delivery systems: From fundamentals to
industrialization
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Huan Zhang, Jie Yang, Rongze Sun, Songren Han, Zhaogang Yang, Lesheng Teng
- Self-assembled nanoformulations of paclitaxel for enhanced cancer
theranostics
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Qing Pei, Bowen Jiang, Dengyuan Hao, Zhigang Xie
- Metabolomics in drug research and development: The recent advances in
technologies and applications
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Huanhuan Pang, Zeping Hu
- The neuroprotective effect of traditional Chinese medicinal plants—A
critical review
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): João Moreira, Mariana Machado, Mónica Dias-Teixeira, Ricardo Ferraz, Cristina Delerue-Matos, Clara Grosso
- Towards understandings of serine/arginine-rich splicing factors
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s): Dianyang Li, Wenying Yu, Maode Lai
- Cover Story
Abstract: Publication date: August 2023Source: Acta Pharmaceutica Sinica B, Volume 13, Issue 8Author(s):
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