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- PKCα inhibitors promote breast cancer immune evasion by
maintaining PD-L1 stability
Abstract: Publication date: Available online 8 August 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Jiaojiao Yu, Yujin Xiang, Yuzhen Gao, Shan Chang, Ren Kong, Xiaoxi Lv, Jinmei Yu, Yunjie Jin, Chenxi Li, Yiran Ma, Zhenhe Wang, Jichao Zhou, Hongyu Yuan, Shuang Shang, Fang Hua, Xiaowei Zhang, Bing Cui, Pingping Li
- Demethylzeylasteral induces PD-L1 ubiquitin–proteasome degradation and
promotes antitumor immunity via targeting USP22
Abstract: Publication date: Available online 8 August 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Yanyan Zhang, Yun Huang, Dianping Yu, Mengting Xu, Hongmei Hu, Qing Zhang, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Jianhua Xia, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang, Sanhong Liu, Weidong Zhang
- Commentary: Inhibition of liver cholesterol synthesis by a diet-induced
gut hormone
Abstract: Publication date: Available online 5 August 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Xiabing Huang, Jianping Ye
- Exemplifying interspecies variation of liposome in vivo fat e by the
effects of anti-PEG antibodies
Abstract: Publication date: Available online 5 August 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Ercan Wu, Juan Guan, Yifei Yu, Shiqi Lin, Tianhao Ding, Yuxiu Chu, Feng Pan, Mengyuan Liu, Yang Yang, Zui Zhang, Jian Zhang, Changyou Zhan, Jun Qian
- Ribonucleotide reductase small subunit M2 promotes the proliferation of
esophageal squamous cell carcinoma cells via HuR-mediated mRNA
stabilization
Abstract: Publication date: Available online 3 August 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Jing Zhang, Qiong Wu, Yifei Xie, Feng Li, Huifang Wei, Yanan Jiang, Yan Qiao, Yinhua Li, Yanan Sun, Han Huang, Mengmeng Ge, Dengyun Zhao, Zigang Dong, Kangdong Liu
- Author correction to ‘3-O-Acetyl-11-keto-β-boswellic acid ameliorated
aberrant metabolic landscape and inhibited autophagy in glioblastoma’
[Acta Pharm Sin B 10 (2020) 301–312]
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Wan Li, Liwen Ren, Xiangjin Zheng, Jinyi Liu, Jinhua Wang, Tengfei Ji, Guanhua Du
- SOX17-mediated immune evasion in early colorectal cancer: From
pre-malignant adaptation to tumor progression
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Yanfeng Gao, Yanping Wang, Jinsong Zhao, Yujun Song
- DNA origami nanodevice with spatial regulation of CD95 signaling for
rheumatoid arthritis treatment
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Miao Mao, Zhe Pu, Yuanqing Zhang
- Lyophilized lymph nodes: A paradigm shift in CAR T-cell delivery for
solid tumor therapy
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Qiuhua Luo, Xiaojing Yan, Hong-Xu Liu, Heran Li
- The chromosome-scale assembly of the Notopterygium incisum genome provides
insight into the structural diversity of coumarins
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Qien Li, Yiqun Dai, Xin-Cheng Huang, Lanlan Sun, Kaixuan Wang, Xiao Guo, Dingqiao Xu, Digao Wan, Latai An, Zixuan Wang, Huanying Tang, Qi Qi, Huihui Zeng, Minjian Qin, Jia-Yu Xue, Yucheng Zhao
- Functional characterization, structural basis, and protein engineering of
a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Zilong Wang, Xueqing Du, Guo Ye, Haotian Wang, Yizhan Liu, Chenrui Liu, Fudong Li, Hans Ågren, Yang Zhou, Junhao Li, Chao He, De-An Guo, Min Ye
- Remote-controlled dexamethasone-duration on eye-surface with a
micelle-magnetic nanoparticulate co-delivery system for dry eye disease
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Qinxiang Zheng, Chaoxiang Ge, Kexin Li, Longxin Wang, Xiaoyu Xia, Xiao Liu, Rashid Mehmood, Jianliang Shen, Kaihui Nan, Wei Chen, Sen Lin
- CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis
of SMAD4-deficient colorectal cancer by trapping TGF-β
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Boning Niu, Tianyi Tian, Lu Wang, Yinmei Tian, Tian Tian, Yuanyuan Guo, Hu Zhou, Zhiping Zhang
- Inhalable nanoparticles with enhanced cuproptosis and cGAS–STING
activation for synergistic lung metastasis immunotherapy
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Chongzheng Yan, Huaiyou Lv, Yafei Feng, Yuhan Li, Zhongxi Zhao
- Dendritic nanomedicine enhances chemo-immunotherapy by disturbing
metabolism of cancer-associated fibroblasts for deep penetration and
activating function of immune cells
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Yunkun Li, Xiaoding Shen, Haitao Ding, Yuxin Zhang, Dayi Pan, Liping Su, Yahui Wu, Zaixiang Fang, Jie Zhou, Qiyong Gong, Kui Luo
- Honey vesicle-like nanoparticles protect aged liver from non-alcoholic
steatohepatitis
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Baolong Liu, Phuong Linh Nguyen, Han Yu, Xingzhi Li, Huiren Wang, Tram Gia Bao Nguyen, Prakash Kumar Sahoo, Meghna Sur, Jay Reddy, Sarah Sillman, Stephen D. Kachman, Bara Altartouri, Guoqing Lu, Sathish Kumar Natarajan, Mahesh Pattabiraman, Jiujiu Yu
- Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for
reinforcing immunogenic cell death and potentiating cancer immunotherapy
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Jie Wang, Zilong Zhang, Yan Zhuo, Zhuan Zhang, Rongrong Chen, Li Liang, Xiaohe Jiang, Di Nie, Chang Liu, Zhiwen Zou, Xiang Li, Jiaxin Li, Bingqi Wang, Rui Wang, Yong Gan, Miaorong Yu
- Discovery of TK-642 as a highly potent, selective, orally bioavailable
pyrazolopyrazine-based allosteric SHP2 inhibitor
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Kai Tang, Shu Wang, Siqi Feng, Xinyu Yang, Yueyang Guo, Xiangli Ren, Linyue Bai, Bin Yu, Hong-Min Liu, Yihui Song
- Discovery of first-in-class DOT1L inhibitors against the R231Q
gain-of-function mutation in the catalytic domain with therapeutic
potential of lung cancer
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Zehui Tan, Ning Guo, Zhi Cao, Shuyu Liu, Jiayu Zhang, Deyi Ma, Jiahao Zhang, Wencai Lv, Nan Jiang, Linghe Zang, Lihui Wang, Xin Zhai
- Inhibition of xanthine oxidase alleviated pancreatic necrosis via
HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Juan Rong, Chenxia Han, Yan Huang, Yiqin Wang, Qi Qiu, Manjiangcuo Wang, Shisheng Wang, Rui Wang, Juqin Yang, Xia Li, Chenggong Hu, Zhiyao Chen, Lihui Deng, Wei Huang, Qing Xia, Dan Du
- Mechanical regulation of lipid and sugar absorption by Piezo1 in
enterocytes
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Tian Tao, Qing Shu, Yawen Zhao, Wenying Guo, Jinting Wang, Yuhao Shi, Shiqi Jia, Hening Zhai, Hui Chen, Cunchuan Wang, Geyang Xu
- Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved
moiety in sesquiterpene lactones, ameliorates arthritic phenotype via
interference DNA binding activity of NF-κB
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Kegang Linghu, Wenqing Cui, Taiqin Li, Yueting Tuo, Dasong Wang, Huiqi Pan, Tian Zhang, Ligen Lin, Hua Yu, Xiaoxia Hu, Haiyang Li, Xiangchun Shen
- Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent
MEOX1 activation
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Lixin Zhao, Yuguang Zhu, Hua Tao, Xiying Chen, Feng Yin, Yingyi Zhang, Jianfeng Qin, Yongyin Huang, Bikun Cai, Yonghao Lin, Jiaxiang Wu, Yu Zhang, Lu Liang, Ao Shen, Xi-Yong Yu
- Semi-synthetic chondroitin sulfate CS-semi5 upregulates miR-122-5p,
conferring a therapeutic effect on osteoarthritis via the p38/MMP13
pathway
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Xiang Li, Ya Zhou, Xuefeng Chen, Hongjun Wang, Shuang Yang, Jun Yang, Yunfeng Song, Zhehui Zhao, Haijing Zhang, Lianqiu Wu
- Suppressing FXR promotes antiviral effects of bile acids via enhancing the
interferon transcription
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Xue Liang, Kunpeng Liu, Xin Jia, Cuiqin Cheng, Meiqi Zhang, Lingdong Kong, Qiqi Li, Zhe Liu, Min Li, Junliang Li, Yao Wang, Anlong Xu
- Phenylalanine deprivation inhibits multiple myeloma progression by
perturbing endoplasmic reticulum homeostasis
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Longhao Cheng, Xiaoxue Wang, Aijun Liu, Ying Zhu, Hu Cheng, Jiangling Yu, Lili Gong, Honglin Liu, Guolin Shen, Lihong Liu
- Screening antimicrobial peptides and probiotics using multiple deep
learning and directed evolution strategies
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Yu Zhang, Li-Hua Liu, Bo Xu, Zhiqian Zhang, Min Yang, Yiyang He, Jingjing Chen, Yang Zhang, Yucheng Hu, Xipeng Chen, Zitong Sun, Qijun Ge, Song Wu, Wei Lei, Kaizheng Li, Hua Cui, Gangzhu Yang, Xuemei Zhao, Man Wang, Jiaqi Xia
- Advancements in precision nanomedicine design targeting the
anoikis-platelet interface of circulating tumor cells
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Manqing Tang, Zhijie Zhang, Ping Wang, Feng Zhao, Lin Miao, Yuming Wang, Yingpeng Li, Yunfei Li, Zhonggao Gao
- Engineered nanoparticles for precise targeted drug delivery and enhanced
therapeutic efficacy in cancer immunotherapy
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Xueqiang Peng, Jianjun Fang, Chuyuan Lou, Liang Yang, Shaobo Shan, Zixian Wang, Yutong Chen, Hangyu Li, Xuexin Li
- Unlocking T cell exhaustion: Insights and implications for CAR-T cell
therapy
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Dian Xiong, Haijun Yu, Zhi-Jun Sun
- The role of botanical triterpenoids and steroids in bile acid metabolism,
transport, and signaling: Pharmacological and toxicological implications
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Zichen Luo, Wei Zhou, Tong Xie, Weichen Xu, Chen Shi, Zihan Xiao, Yu Si, Yan Ma, Qingling Ren, Liuqing Di, Jinjun Shan
- Encoding and display technologies for combinatorial libraries in drug
discovery: The coming of age from biology to therapy
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Yu Fan, Ruibing Feng, Xinya Zhang, Zhen-Liang Wang, Feng Xiong, Shuihua Zhang, Zhang-Feng Zhong, Hua Yu, Qing-Wen Zhang, Zhang Zhang, Yitao Wang, Guodong Li
- Mitophagy and cGAS–STING crosstalk in neuroinflammation
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Xiaogang Zhou, Jing Wang, Lu Yu, Gan Qiao, Dalian Qin, Betty Yuen-Kwan Law, Fang Ren, Jianming Wu, Anguo Wu
- Progranulin: A promising biomarker and therapeutic target for fibrotic
diseases
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Fan Yang, Ming-Han Cheng, Hai-Feng Pan, Jian Gao
- Therapeutic potential of targeting protein tyrosine phosphatases in liver
diseases
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s): Ao Wang, Yi Zhang, Xinting Lv, Guang Liang
- Cover Story
Abstract: Publication date: August 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 8Author(s):
- Discovery of novel small molecules targeting hepatitis B virus core
protein from marine natural products with HiBiT-based high-throughput
screening
Abstract: Publication date: Available online 3 August 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Chao Huang, Yang Jin, Panpan Fu, Kongying Hu, Mengxue Wang, Wenjing Zai, Ting Hua, Xinluo Song, Jianyu Ye, Yiqing Zhang, Gan Luo, Haiyu wang, Jiangxia Liu, Jieliang Chen, Xuwen Li, Zhenghong Yuan
- Drug discovery targeting thyroid hormone receptor β (THRβ) for the
treatment of liver diseases and other medical indications
Abstract: Publication date: Available online 2 August 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Kean Wang, Feiyang Chen, Jiang Wang, Hong Liu
- Advancements and challenges in immunocytokines: A new arsenal against
cancer
Abstract: Publication date: Available online 2 August 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Wenqiang Shi, Nan Liu, Huili Lu
- L-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of
glutaminolysis in non-alcoholic steatohepatitis
Abstract: Publication date: Available online 31 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Yiding Zhang, Lin Xie, Masayuki Fujinaga, Yusuke Kurihara, Masanao Ogawa, Katsushi Kumata, Wakana Mori, Tomomi Kokufuta, Nobuki Nengaki, Hidekatsu Wakizaka, Rui Luo, Feng Wang, Kuan Hu, Ming-Rong Zhang
- Development of a bacteria-nanosapper for the active delivery of ZIF-8
particles containing therapeutic genes for cancer immune therapy
Abstract: Publication date: Available online 27 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Yiting Qiao, Miao Luo, Yufei Wang, Haoxiang Qi, Menglan Wang, Yunxin Pei, Mengqing Sun, Zhengguo Zhang, Jiacheng Huang, Pengyu Gong, Shusen Zheng, Jianxiang Chen
- Precise targeting of lipid metabolism in the era of immuno-oncology and
the latest advances in nano-based drug delivery systems for cancer therapy
Abstract: Publication date: Available online 27 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Hongyan Zhang, Yujie Li, Jingyi Huang, Limei Shen, Yang Xiong
- Avenanthramide A potentiates Bim-mediated antineoplastic properties of
5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop
in colorectal cancer
Abstract: Publication date: Available online 25 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Rong Fu, Zhangfeng Dou, Ning Li, Xueyuan Fan, Sajid Amin, Jinqi Zhang, Yuqing Wang, Zongwei Li, Zhuoyu Li, Peng Yang
- Pretheranostic agents with extraordinary NIRF/photoacoustic imaging
performance and photothermal oncotherapy efficacy
Abstract: Publication date: Available online 24 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Liu Shi, Zhenzhou Chen, Jiaxin Ou, En Liang, Zhipeng Chen, Qiuyue Fu, Lan Huang, Kui Cheng
- Discovery of a potent PROTAC degrader for RNA demethylase FTO as
antileukemic therapy
Abstract: Publication date: Available online 24 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Lu Liu, Yuanlai Qiu, Yuying Suo, Siyao Tong, Yiqing Wang, Xi Zhang, Liang Chen, Yue Huang, Huchen Zhou, Hu Zhou, Ze Dong, Cai-Guang Yang
- RMC-7977, a highly selective inhibitor of the active RAS-GTP to treat
pancreatic cancer
Abstract: Publication date: Available online 20 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Ying-Qi Song, Qingjun Li, Chunquan Sheng
- Nanotechnology-based tumor metabolic reprogramming: Insights into
nutrient-delivery and metabolism reactivation therapy
Abstract: Publication date: Available online 20 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Xi Hu, Daishun Ling
- Modeling on in vivo disposition and cellular transportation of RNA lipid
nanoparticles via quantum mechanics/physiologically-based pharmacokinetic
approaches
Abstract: Publication date: Available online 18 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Wei Wang, Shiwei Deng, Jinzhong Lin, Defang Ouyang
- Discovery of a novel exceptionally potent and orally active Nur77 ligand
NB1 with a distinct binding mode for cancer therapy
Abstract: Publication date: Available online 14 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Jun Chen, Taige Zhao, Wenbin Hong, Hongsheng Li, Mingtao Ao, Yijing Zhong, Xiaoya Chen, Yingkun Qiu, Xiumin Wang, Zhen Wu, Tianwei Lin, Baicun Li, Xueqin Chen, Meijuan Fang
- Natural product mediated mesenchymal–epithelial remodeling by covalently
binding ENO1 to degrade m6A modified β-catenin mRNA
Abstract: Publication date: Available online 14 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Tianyang Chen, Guangju Liu, Sisi Chen, Fengyuan Zhang, Shuoqian Ma, Yongping Bai, Quan Zhang, Yahui Ding
- Controlling tumor progression and recurrence in mice through combined
treatment with a PD-L1 inhibitor and a designer Salmonella strain that
delivers GM-CSF
Abstract: Publication date: Available online 10 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Heung Jin Jeon, Daejin Lim, EunA. So, Solbi Kim, Jae-Ho Jeong, Miryoung Song, Hyo-Jin Lee
- The microneedle bandages provide new hope for healing diabetic wounds
Abstract: Publication date: Available online 10 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Saadullah Khattak, Hong-Tao Xu, Jianliang Shen
- Nanomedicine regulating PSC-mediated intercellular crosstalk: Mechanisms
and therapeutic strategies
Abstract: Publication date: Available online 10 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Hui Wang, Liang Qi, Han Han, Xuena Li, Mengmeng Han, Lei Xing, Ling Li, Hulin Jiang
- Jun12682, a potent SARS-CoV-2 papain-like protease inhibitor with
exceptional antiviral efficacy in mice
Abstract: Publication date: Available online 6 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Mianling Yang, Meehyein Kim, Peng Zhan
- Target fishing and mechanistic insights of the natural anticancer drug
candidate chlorogenic acid
Abstract: Publication date: Available online 6 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Qinghua Wang, Tingting Du, Zhihui Zhang, Qingyang Zhang, Jie Zhang, Wenbin Li, Jian-Dong Jiang, Xiaoguang Chen, Hai-Yu Hu
- Spatial metabolomics highlights metabolic reprogramming in acute myeloid
leukemia mice through creatine pathway
Abstract: Publication date: Available online 6 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Yucheng Bao, Jing Qiao, Wenjie Gong, Ruihong Zhang, Yanting Zhou, Yinyin Xie, Yuan Xie, Jiuming He, Tong Yin
- Strategies for intravesical drug delivery: From bladder physiological
barriers and potential transport mechanisms.
Abstract: Publication date: Available online 6 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Zhengan Li, Kaichao Wen, Jiheng Liu, Chuan Zhang, Feng Zhang, Fengqian Li
- Enhanced radiotheranostic targeting of integrin α5β1 with
PEGylation-enabled peptide multidisplay (PEGibody): A strategy for
prolonged tumor retention with fast blood clearance
Abstract: Publication date: Available online 6 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Siqi Zhang, Xiaohui Ma, Jiang Wu, Jieting Shen, Yuntao Shi, Xingkai Wang, Lin Xie, Xiaona Sun, Yuxuan Wu, Hao Tian, Xin Gao, Xueyao Chen, Hongyi Huang, Lu Chen, Xuekai Song, Qichen Hu, Hailong Zhang, Feng Wang, Zhao-Hui Jin, Ming-Rong Zhang
- Zinc oxide nanoparticles with catalase-like nanozyme activity and
near-infrared light response: A combination of effective photodynamic
therapy, autophagy, ferroptosis, and antitumor immunity
Abstract: Publication date: Available online 5 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Jingru Wang, Man Liu, Jingwen Wang, Zhuoyue Li, Zhenhan Feng, Meiqi Xu, Hui Wang, Hui Li, Zhantao Li, Jianming Yu, Junwei Liu, Qingchao Wei, Shuang Zhang, Xuan Zhang
- Author correction to “Identification of the dietary supplement capsaicin
as an inhibitor of Lassa virus entry” [Acta Pharmaceutica Sinica B 10
(2020) 789–798]
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Ke Tang, Xiaoyu Zhang, Ying Guo
- Commentary: The central lymphatic drainage in pharmacological, surgical
and physical therapies of Alzheimer's disease
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Lixuan Ren, Jianping Ye
- Discovery and characterization of novel potent non-covalent small molecule
inhibitors targeting papain-like protease from SARS-CoV-2
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Miao Zheng, Bo Feng, Yumin Zhang, Xin Liu, Na Zhao, Hui Liu, Zichao Xu, Xinheng He, Zhiyan Qu, Shizhao Chen, Zhidong Jiang, Xi Cheng, Hong Liu, Yi Zang, Linxiang Zhao, Jie Zheng, Leike Zhang, Jia Li, Yu Zhou
- Antitumor activity and low gastrointestinal toxicity of a novel selective
inhibitor of nuclear export, SZJK-0421, in multiple myeloma
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Jing Wang, Hang Miao, Xuxing Shen, Lin Yang, Yongqiang Zhu, Lijuan Chen
- The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide
extend Caenorhabditis elegans lifespan and healthspan
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Wenfeng Li, Shuming Chen, Jing Lang, Jing Luo, Jiahui Chen, Liping Zhang, Zhijie Sun, Deli Dong
- Sequential dual-locking strategy using photoactivated Pt(IV)-based
metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy
by triggering ferroptosis and macrophage polarization
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Jun Li, Qiang Zhang, Hao Yang, Wenli Lu, Yulong Fu, Yingcai Xiong, Xuan Wang, Tianming Lu, Yanlin Xin, Zejuan Xie, Weichao Chen, Guoqiang Wang, Yuanyuan Guo, Ruogu Qi
- A novel marine-derived anti-acute kidney injury agent targeting
peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Ping Yu, Tanwei Gu, Yueyang Rao, Weimin Liang, Xi Zhang, Huanguo Jiang, Jindi Lu, Jianglian She, Jianmin Guo, Wei Yang, Yonghong Liu, Yingfeng Tu, Lan Tang, Xuefeng Zhou
- Enhancing immunotherapy efficacy against MHC-I deficient triple-negative
breast cancer using LCL161-loaded macrophage membrane-decorated
nanoparticles
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Wen Zhang, Yihui Zhai, Ying Cai, Xiang Gong, Yunxuan Jiang, Rong Rong, Chao Zheng, Binyu Zhu, Helen He Zhu, Hao Wang, Yaping Li, Pengcheng Zhang
- Triterpenoids-templated self-assembly nanosystem for biomimetic delivery
of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC
immunotherapy
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Bing-Chen Zhang, Chun-Mei Lai, Bang-Yue Luo, Jing-Wei Shao
- An antibiotic-free platform for eliminating persistent Helicobacter pylori
infection without disrupting gut microbiota
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Yongkang Lai, Tinglin Zhang, Xiaojing Yin, Chunping Zhu, Yiqi Du, Zhaoshen Li, Jie Gao
- M1-polarized macrophage-derived cellular nanovesicle-coated lipid
nanoparticles for enhanced cancer treatment through hybridization of gene
therapy and cancer immunotherapy
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Ha Eun Shin, Jun-Hyeok Han, Seungyong Shin, Ga-Hyun Bae, Boram Son, Tae-Hyung Kim, Hee Ho Park, Chun Gwon Park, Wooram Park
- Julolidinyl aza-BODIPYs as NIR-II fluorophores for the bioimaging of
nanocarriers
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Chang Liu, Yifan Cai, Zichen Zhang, Yi Lu, Quangang Zhu, Haisheng He, Zhongjian Chen, Weili Zhao, Wei Wu
- Selectively T cell phosphorylation activation of azvudine in the thymus
tissue with immune protection effect
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Ning Sheng, Rui Li, Yang Li, Zhe Wang, Lulu Wang, Yuhuan Li, Jinlan Zhang, Jiandong Jiang
- Glycnsisitin A: A promising bicyclic peptide against heart failure that
facilitates TFRC-mediated uptake of iron in cardiomyocytes
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Jichao Zhou, Yuanyuan Liu, Xiaoli Wei, Meng Yuan, Xu Zhang, Lingfeng Qin, Bing Cui, Pingping Li, Jing Zhang, Ziming Feng, Jianshuang Jiang, Xiang Yuan, Ruibing Xu, Zhimeng Zhang, Peicheng Zhang, Xiaowei Zhang, Yanan Yang
- Design and optimization of piperidine-substituted
thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug
resistance and pharmacokinetic profiles
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Yanying Sun, Zhenzhen Zhou, Zhongling Shi, Fabao Zhao, Minghui Xie, Zongji Zhuo, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
- Deep simulated annealing for the discovery of novel dental anesthetics
with local anesthesia and anti-inflammatory properties
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Yihang Hao, Haofan Wang, Xianggen Liu, Wenrui Gai, Shilong Hu, Wencheng Liu, Zhuang Miao, Yu Gan, Xianghua Yu, Rongjia Shi, Yongzhen Tan, Ting Kang, Ao Hai, Yi Zhao, Yihang Fu, Yaling Tang, Ling Ye, Jin Liu, Xinhua Liang, Bowen Ke
- Gut commensal metabolite rhamnose promotes macrophages phagocytosis by
activating SLC12A4 and protects against sepsis in mice
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Dongping Li, Rongjuan Wei, Xianglong Zhang, Shenhai Gong, Meijuan Wan, Fangzhao Wang, Jiaxin Li, Meiling Chen, Ruofan Liu, Yantong Wan, Yinghao Hong, Zhenhua Zeng, Peng Gu, Zhang Wang, Kutty Selva Nandakumar, Yong Jiang, Hongwei Zhou, Peng Chen
- PIM1–HDAC2 axis modulates intestinal homeostasis through epigenetic
modification
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Jianming Yang, Yawen Xiao, Ningning Zhao, Geng Pei, Yan Sun, Xinyu Sun, Kaiyuan Yu, Chunhui Miao, Ran Liu, Junqiang Lv, Hongyu Chu, Lu Zhou, Bangmao Wang, Zhi Yao, Quan Wang
- ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes
atherosclerosis by regulating EndMT
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Mengdie Dong, Yunjia Zhang, Minghong Chen, Yongkang Tan, Jiao Min, Xian He, Fuhao Liu, Jiaming Gu, Hong Jiang, Longbin Zheng, Jiajing Chen, Quanwen Yin, Xuesong Li, Xiang Chen, Yongfeng Shao, Yong Ji, Hongshan Chen
- Exosomes derived from tumor adjacent fibroblasts efficiently target
pancreatic tumors
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Saini Setua, Shabia Shabir, Poornima Shaji, Ana Martinez Bulnes, Anupam Dhasmana, Swathi Holla, Nivesh K. Mittal, Nirakar Sahoo, Tripti Saini, Francesco Giorgianni, Mohammad Sikander, Andrew E. Massey, Bilal B. Hafeez, Manish K. Tripathi, Vincent P. Diego, Meena Jaggi, Junming Yue, Nadeem Zafar, Murali M. Yallapu, Stephen W. Behrman
- Fenofibrate-promoted hepatomegaly and liver regeneration are
PPARα-dependent and partially related to the YAP pathway
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Shicheng Fan, Yue Gao, Pengfei Zhao, Guomin Xie, Yanying Zhou, Xiao Yang, Xuan Li, Shuaishuai Zhang, Frank J. Gonzalez, Aijuan Qu, Min Huang, Huichang Bi
- Disruption of cyclin D1 degradation leads to the development of mantle
cell lymphoma
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Ke Lu, Ming Zhang, Hongyu Qin, Siyu Shen, Haiqing Song, Hua Jiang, Chunxiang Zhang, Guozhi Xiao, Liping Tong, Qing Jiang, Di Chen
- KHK-A promotes fructose-dependent colorectal cancer liver metastasis by
facilitating the phosphorylation and translocation of PKM2
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Chaofan Peng, Peng Yang, Dongsheng Zhang, Chi Jin, Wen Peng, Tuo Wang, Qingyang Sun, Zhihao Chen, Yifei Feng, Yueming Sun
- LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42
and inhibiting STAT1 activation
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Shishi He, Guowei Huang, Rong Lei, Rurong Jia, Zhanghai He, Jiewen Chen, Hongyan Huang, Zixian Huang, Ailifeire Yilihamu, Xun Li, Zilin Zhuang, Mengjia Han, Xueman Chen, Di Huang, Yan Nie
- In silico off-target profiling for enhanced drug safety
assessment
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Jin Liu, Yike Gui, Jingxin Rao, Jingjing Sun, Gang Wang, Qun Ren, Ning Qu, Buying Niu, Zhiyi Chen, Xia Sheng, Yitian Wang, Mingyue Zheng, Xutong Li
- Complications and comorbidities associated with antineoplastic
chemotherapy: Rethinking drug design and delivery for anticancer therapy
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Xiaoman Mao, Shuang Wu, Dandan Huang, Chong Li
- Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Porkizhi Arjunan, Durga Kathirvelu, Gokulnath Mahalingam, Ashish Kumar Goel, Uday George Zacharaiah, Alok Srivastava, Srujan Marepally
- The emerging role of tranexamic acid and its principal target,
plasminogen, in skeletal health
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Weixin Xie, Antonia Donat, Shan Jiang, Anke Baranowsky, Johannes Keller
- Single-domain antibodies as therapeutics for solid tumor treatment
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Mingkai Wang, Tianlei Ying, Yanling Wu
- Therapeutic strategies of targeting non-apoptotic regulated cell death
(RCD) with small-molecule compounds in cancer
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Xin Jin, Wenke Jin, Linlin Tong, Jia Zhao, Lan Zhang, Na Lin
- Monoclonal antibodies and aptamers: The future therapeutics for
Alzheimer's disease
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s): Alvaro Barrera-Ocampo
- Cover Story
Abstract: Publication date: July 2024Source: Acta Pharmaceutica Sinica B, Volume 14, Issue 7Author(s):
- Icaritin inhibits the progression of urothelial cancer by suppressing
PADI2-mediated neutrophil infiltration and neutrophil extracellular trap
formation
Abstract: Publication date: Available online 1 July 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Zezhong Mou, Yiling Chen, Jinzhong Hu, Yun Hu, Lujia Zou, Xinan Chen, Shenghua Liu, Qiuping Yin, Jian Gong, Shuchen Li, Shanhua Mao, Chenyang Xu, Haowen Jiang
- Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma
cell growth by disrupting alternative splicing
Abstract: Publication date: Available online 29 June 2024Source: Acta Pharmaceutica Sinica BAuthor(s): Wenkang Fu, Yanyan Lin, Mingzhen Bai, Jia Yao, Chongfei Huang, Long Gao, Ningning Mi, Haidong Ma, Liang Tian, Ping Yue, Yong Zhang, Jinduo zhang, Yanxian Ren, Liyun Ding, Lunzhi Dai, Joseph W. Leung, Jinqiu Yuan, Wenhua Zhang, Wenbo Meng
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