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- A Positive Feedback Loop Between CXCL16 and the Inflammatory Factors
IL-17A and TGF-β Promotes Large Artery Atherosclerosis by Activating the
STAT3/NF-κB Pathway
Abstract: CXC chemokine ligand 16 (CXCL16) expression is often observed in studies related to atherosclerosis (AS). However, the process by which CXCL16 promotes AS is still unknown. CXCL16 has the potential to be a therapeutic target for atherosclerotic disease, and we studied whether CXCL16 expression in carotid atherosclerotic plaques is correlated with plaque stability. The results revealed that the expression level of CXCL16 in unstable plaques was greater than that in stable plaques (). In an in vitro model, CXCL16 promoted the expression of interleukin-17A (IL-17A) and transforming growth factor-β (TGF-β) and the release of STAT3/NF-κB pathway-associated proteins by regulating the expression of IL-17A, TGF-β, and CXCL16. In conclusion, there is a positive feedback regulatory pathway between inflammatory factors and CXCL16 during the progression of carotid AS. Inflammatory factors and CXCL16 promote each other’s expression and activate the STAT3/NF-κB pathway to promote carotid AS. CXCL16 is highly expressed in carotid atherosclerotic plaques, affecting plaque stability and further leading to the development of AS-related diseases such as ischaemic stroke. Thus, we hypothesise that CXCL16 is a potential therapeutic target for treating AS and AS-related diseases.
PubDate: Mon, 24 Mar 2025 06:34:49 +000
- The Effect of Vitamin D3 Injection Combined With High-Intensity Interval
Training on Excessive Autophagy in the Heart Tissue of Type 2
Diabetes–Induced Rats: An Analysis of the
mTOR–Beclin-1–Fyco-1–Cathepsin D Pathway
Abstract: Conclusion: Type 2 diabetes increases autophagy in the left ventricle, marked by altered levels of key autophagy proteins. HIIT and vitamin D3 injections mitigate these effects by enhancing mTOR signaling and reducing excessive autophagy. These interventions show promise as nonpharmacological strategies to improve cardiac health in Type 2 diabetes and could be incorporated into clinical and rehabilitation programs.
PubDate: Wed, 19 Mar 2025 20:18:53 +000
- Comprehensive Analysis Based on Genes Associated With Cuproptosis,
Ferroptosis, and Pyroptosis for the Prediction of Diagnosis and Therapies
in Coronary Artery Disease
Abstract: Coronary artery disease (CAD) is a complex condition influenced by genetic factors, lifestyle, and other risk factors that contribute to increased mortality. This study is aimed at evaluating the diagnostic potential of genes associated with cuproptosis, ferroptosis, and pyroptosis (CFP) using network modularization and machine learning methods. CAD-related datasets GSE42148, GSE20680, and GSE20681 were sourced from the GEO database, and genes related to CFP genes were gathered from MsigDB and FerrDb datasets and literature. To identify diagnostic genes linked to these pathways, weighted gene coexpression network analysis (WGCNA) was used to isolate CAD-related modules. The diagnostic accuracy of key genes in these modules was then assessed using LASSO, SVM, and random forest models. Immunity and drug sensitivity correlation analyses were subsequently performed to investigate possible underlying mechanisms. The function of a potential gene, STK17B, was analyzed through western blot and transwell assays. Two CAD-related modules with strong correlations were identified and validated. The SVM model outperformed LASSO and random forest models, demonstrating superior discriminative power ( in the blue module and in the turquoise module), with nine key genes identified: CTDSP2, DHRS7, NLRP1, MARCKS, PELI1, RILPL2, JUNB, STK17B, and SLC40A1. Knockdown of STK17B inhibited cell migration and invasion in human umbilical vein endothelial cells. In summary, our findings suggest that CFP genes hold potential as diagnostic biomarkers and therapeutic targets, with STK17B playing a role in CAD progression.
PubDate: Sat, 15 Mar 2025 01:34:21 +000
- Clinical and Echocardiographic Risk Factors of Adverse Outcomes in Young
Patients With Dilated Cardiomyopathy
Abstract: Conclusions: Intensive monitoring and medical care may be beneficial for young adult DCM patients with defined risk factors such as smoking, elevated NT-proBNP and CRP, lower LVEF, and enlarged LV diameter. Our findings suggest that personalized intensive monitoring and medical care based on identified risk factors may improve outcomes in young adult DCM patients.
PubDate: Sat, 08 Mar 2025 01:34:32 +000
- Cysteine-Rich Protein 61 (CCN1) Deficiency Alleviated Cardiac Remodeling
in 5/6 Nephrectomized Mice by Suppressing the MAPK Signaling Pathway
Abstract: Conclusion: Our in vivo and in vitro study showed that specific CCN1 deficiency markedly alleviated cardiac remodeling in 5/6 Nx mice through the inhibition of the MAPK pathway.
PubDate: Thu, 27 Feb 2025 03:34:40 +000
- Urine Output as a Novel Predictor for In-Hospital Mortality in Acute
Pulmonary Embolism Patients: Training With the MIMIC Database and
Validation With Independent Cohort
Abstract: Conclusion: Our study revealed a negative association of urine output with in-hospital mortality in acute pulmonary embolism patients, with the optimal urine output being significantly higher than the value of other critical illnesses.
PubDate: Wed, 26 Feb 2025 06:34:40 +000
- Impacts of CD36 Variants on Plasma Lipid Levels and the Risk of
Early-Onset Coronary Artery Disease: A Systematic Review and Meta-Analysis
Abstract: Conclusions: The rs1761667, rs1049673, and rs3211956 variants of the CD36 gene have significant impacts on lipid levels and may serve as genetic markers for the risk of EOCAD primarily in Chinese. The impacts of CD36 variants on EOCAD risk are mediated, at least partly, by dyslipidemia. Genetic screening of CD36 gene variants may be helpful for early intervention or prevention of EOCAD in individuals with high risk factors.
PubDate: Tue, 25 Feb 2025 00:19:59 +000
- The Acute Effects of Motor Imagery Combined With Action Observation
Breathing Exercise on Cardiorespiratory Responses, Brain Activity, and
Cognition: A Randomized, Controlled Trial
Abstract: Trial Registration: ClinicalTrials.gov identifier: NCT06099483
PubDate: Sat, 22 Feb 2025 03:49:39 +000
- Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A
Study Based on Proteome-Wide Mendelian Randomization and Colocalization
Analysis
Abstract: Conclusions: This study identifies plasma proteins with significant causal associations with CVDs, providing a more comprehensive understanding of potential therapeutic targets. These findings contribute to our knowledge of the underlying mechanisms and offer insights into potential avenues for treatment.
PubDate: Fri, 21 Feb 2025 02:18:59 +000
- Frontiers and Hotspot Evolution of NLRP3 Inflammasome in Myocardial
Infarction Research: A Bibliometric Analysis From 2013 to 2024
Abstract: The NACHT, leucine-rich repeat, and pyrin domain–containing protein 3 (NLRP3) inflammasome plays an essential role in myocardial infarction (MI) development. Up to now, no bibliometric analyses of NLRP3 in MI have been performed. Publications related to NLRP3 in MI from 1 January 2013 to 20 August 2024 were extracted from the Web of Science Core Collection (WoSCC). HistCite Pro, CiteSpace, VOSviewer, Scimago Graphica, and bibliometric online analysis program were used for bibliometric analysis and visualization. The impact of publications was assessed using the total global citation score (TGCS). A total of 324 articles (284 articles and 40 reviews) were included. China has published the most in this field, followed by the United States. Harbin Medical University was the leading institution for research related to NLRP3 in MI. Professor Abbate A. from the United States has made significant achievements in this field. International Immunopharmacology was the most active journal and Journal of Cardiovascular Pharmacology was the most cited journal. This study systematically summarizes the research results of NLRP3 in MI over the past 12 years. NLRP3 in myocardial ischemia–reperfusion injury (MIRI) will become a hot research topic, and translational research on NLRP3 inhibitors in MIRI will benefit a greater number of patients.
PubDate: Wed, 19 Feb 2025 22:18:30 +000
- Concomitant Atrial Fibrillation Radiofrequency Ablation During Total
Thoracoscopic Valve Replacement: Safety, Early-Term Efficacy, and
Predictors of Early Atrial Arrhythmia Recurrence
Abstract: Conclusions: Concomitant AF RFA during TTVR is a safe and effective strategy for managing AF in minimally invasive valve surgery. Early predictors of AAR include age, AF duration, BMI, AF type, left atrial diameter, and ablation extent. Future multicenter studies with longer follow-ups are needed to validate these findings and provide robust evidence on long-term outcomes.
PubDate: Mon, 17 Feb 2025 08:49:26 +000
- The Prognostic Significance of the DBIL/HDLC Ratio in Patients With
Dilated Cardiomyopathy
Abstract: Conclusion: The DBIL/HDLC ratio could serve as a simple and cost-effective tool for evaluating prognosis in DCM.
PubDate: Sat, 15 Feb 2025 06:48:23 +000
- Efficacy and Safety of Stellate Ganglion Block for Treating Angina
Pectoris: A Systematic Review and Meta-Analysis
Abstract: Conclusion: SGB is effective in alleviating myocardial injury and reducing the incidence of AMI and rehospitalization in patients with AP. Nevertheless, the limited number and relatively low quality of included studies emphasize the requirement for more high-quality research to verify these conclusions.
PubDate: Thu, 13 Feb 2025 05:34:18 +000
- Imperatorin’s Effect on Myocardial Infarction Based on Network
Pharmacology and Molecular Docking
Abstract: Conclusion: Imperatorin attenuated MI by inhibiting the ACE–Ang II–AT1R axis. Thus, imperatorin might be considered a potential therapeutic agent to cure MI.
PubDate: Mon, 13 Jan 2025 09:50:51 +000
- Assessment of Risk Factors Associated With Coronary Artery Disease (CAD)
in the Western Libyan Patients
Abstract: Coronary artery disease (CAD) is the leading cause of death worldwide in both men and women. Accordingly, we retrospectively reviewed the effects of various risk factors on coronary angiographic outcomes. Data were collected from the catheter lab through Tripoli University Hospital records, whereas the team reviewed clinical data and coronary artery diagrams for 1 year from 01/04/2019 to 31/03/2020. In our study, the total number of cases was 666, 401 male and 265 female, aged between 27 and 91 years. Our analysis revealed a significantly higher incidence of CAD among male smokers under 60. Conversely, a majority of nonsmoker patients were female. The most common risk factors for women were diabetes mellitus (DM) and hypertension (HTN) (12% and 13%, respectively). While the men share the significant effects of smoking on coronary angiography (C. Angio) findings (40.52%), most of them underwent a percutaneous coronary intervention (PCI). In our study, there was evidence that CAD is a prevalent disease among middle-aged populations with male gender preference. The risk factors, including diabetes, HTN, and smoking, are the most contributing factors for developing CAD in Libya.
PubDate: Sat, 11 Jan 2025 06:34:59 +000
- Effectiveness and Safety of Dose-Specific DOACs in Patients With Atrial
Fibrillation: A Systematic Review and Network Meta-Analysis
Abstract: Conclusions: This study found that all DOACs provided comparable or superior effectiveness and safety to warfarin. SD apixaban, SD edoxaban, and LD edoxaban achieved a favorable balance between preventing S/SE and MB risk.
PubDate: Mon, 06 Jan 2025 14:29:15 +000
- Heparin and Bivalirudin in Percutaneous Coronary Intervention for Acute
Coronary Syndromes: A Review Article
Abstract: Acute coronary syndrome (ACS) is one of the most common leading global causes of mortality, encompassing ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina (UA). Percutaneous coronary intervention (PCI) has become a pivotal therapeutic approach for ACS, underscoring the importance of anticoagulation strategies. Among the commonly employed anticoagulants in PCI, heparin and bivalirudin take precedence, with heparin serving as the archetypal choice. Nevertheless, the determination of an optimal anticoagulation regimen remains a point of contention in contemporary clinical practice. To address the differences in anticoagulants during PCI, we meticulously conducted a literature review through PubMed and Web of Science, employing search terms such as “heparin,” “bivalirudin,” “percutaneous coronary intervention,” and “acute coronary syndrome.” For patients with PIC brought on by STEMI, NSTEMI, and stable or UA pectoris, the review focused on randomized controlled trials to assess and compare the efficacy and safety of heparin and bivalirudin as anticoagulant options. This systematic review is aimed at furnishing valuable insights into the ongoing debate surrounding the choice of anticoagulation regimens in PCI. By scrutinizing clinical evidence derived from relevant trials, we seek to inform and guide healthcare practitioners in making informed decisions based on the unique requirements of patients with various ACS presentations.
PubDate: Thu, 26 Dec 2024 11:03:06 +000
- Thymidine Phosphorylase Promotes Abdominal Aortic Aneurysm via VSMC
Modulation and Matrix Remodeling in Mice and Humans
Abstract: Conclusion: TYMP emerges as a novel regulatory force in vascular biology, influencing VSMC function and inflammatory responses to promote AAA development.
PubDate: Wed, 18 Dec 2024 08:50:07 +000
- Application of the Left Ventricular Pressure–Strain Loop Technique in
Monitoring Improvement Factors of Patients With Heart Failure Reduced
Ejection Fraction
Abstract: The left ventricular pressure–strain loop (PSL) is a new technique based on ultrasound for noninvasive quantitative evaluation of global and local myocardial work (MW). This study is aimed at evaluating improvement factors of patients with heart failure (HF) reduced ejection fraction (HFrEF) using the PSL technique. A total of 88 patients with HF were enrolled in this study, which had ≤ 40% left ventricular ejection fraction (LVEF). The EchoPAC workstation was used to obtain the global longitudinal strain (GLS) and MW parameters of the left ventricle. All patients have taken medicines for HF treatments for 6–12 months. The improvements of HF after therapies were evaluated according to the following recommended criteria. The clinical characteristics of patients with improved and nonimproved groups were stratified via univariate or multivariate logistic regression analysis, receiver operating characteristic (ROC), and the area under ROC (area under the curve (AUC)). There were no significant differences in general medical information, the underlying diseases, laboratory findings, myocardial enzyme activities, and taking medicines between the improved and nonimproved LVEF patients (). There were significant differences in LVEF of patients at admission, left ventricular end-diastolic diameter (LVEDD), interventricular septum thickness (IVST), early diastolic mitral flow peak velocity E (E peak), GLS, global myocardial work index (GWI), global myocardial constructive work (GCW), and global myocardial work efficiency (GWE) between the two groups (). Univariate and multivariate logistic regression analyses confirmed that GWI and GCW were critical predictive factors for LVEF improvement in patients with HF. ROC curve showed that the AUC of GWI and GCW were 0.796 and 0.779 at the cut-off of 741 mmHg% for GWI and 973.5 mmHg% for GCW, respectively. The sensitivities of GWI and GCW were 65% and 75%, and the specificities of GWI and GCW were 83.3% and 79.2% at given cut-off values. These results revealed that GWI and GCW were independent predictors of improvement of LVEF in patients with HFrEF.
PubDate: Tue, 17 Dec 2024 12:03:23 +000
- DJ-1 as a Novel Therapeutic Target for Mitigating Myocardial
Ischemia–Reperfusion Injury
Abstract: Ischemic heart disease (IHD) remains one of the most prominent causes of mortality and morbidity globally, and the risk of ischemia–reperfusion injury is becoming more severe and constant. This underscores the need to develop new methods to protect the heart from damage. DJ-1 is a multifunctional intracellular protein encoded by the PARK7 gene that plays roles in processes including the control of autophagy, the preservation of mitochondrial integrity, the prevention of apoptosis, and the elimination of oxidative stress. DJ-1 has recently been the focus of growing interest as a target molecule relevant to treating myocardial ischemia–reperfusion injury due to its protective properties and its role in cellular response mechanisms. Consistently, DJ-1-related interventions, such as its exogenous administration or the use of pharmacological agents, have been demonstrated to help protect the myocardium from ischemia–reperfusion injury and associated adverse outcomes. This review provides an overview of DJ-1 and its therapeutic relevance in the myocardium in the setting of ischemia and reperfusion.
PubDate: Thu, 12 Dec 2024 23:20:12 +000
- Dehydroevodiamine Alleviates Doxorubicin-Induced Cardiomyocyte Injury by
Regulating Neuregulin-1/ErbB Signaling
Abstract: Conclusion: DHE protects cardiomyocytes against DOX by regulating NRG1/ErbB pathway. DHE may be a potential agent for the prevention and treatment of DIC.
PubDate: Sat, 07 Dec 2024 10:45:23 +000
- Cysteine Leukotriene Receptor Antagonist—Montelukast—Treatment
Improves Experimental Abdominal Aortic Aneurysms in Mice
Abstract: Conclusion: Montelukast treatment improves experimental nondissected AAAs in mice partly by improving aortic inflammation.
PubDate: Wed, 27 Nov 2024 09:18:50 +000
- Angiotensin Receptor–Neprilysin Inhibitor in Heart Failure Patients
With Renal Dysfunction
Abstract: Heart failure (HF) and renal dysfunction often coexist and interact in many complex and bidirectional pathways, leading to detrimental effects on patient outcomes. The treatment of HF patients with renal dysfunction presents a significant clinical challenge. Interestingly, sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), may have beneficial effects on cardiac and renal outcomes in patients with HF with reduced ejection fraction, particularly by slowing the rate of decrease in the estimated glomerular filtration rate compared to a single angiotensin–converting enzyme inhibitor. Recently, more reports have emphasized the renal protection of sacubitril/valsartan in patients with HF. In HF patients with renal dysfunction, however, there is no strong evidence supporting the use of sacubitril/valsartan to reduce the absolute risk of hyperkalemia and worsening renal function; therefore, the administration of ARNI requires a careful balance between the benefits and risks. Furthermore, the lack of evidence-based management highlights the importance of an individualized approach based on published experience and multidisciplinary collaborations, as well as underlines the need for in-depth studies investigating the underlying mechanisms in cardiorenal interactions with a focus on treatments.
PubDate: Mon, 04 Nov 2024 10:48:29 +000
- Overexpression of TRPV6 Inhibits Coronary Atherosclerosis–Related
Inflammatory Response and Cell Apoptosis via the PKA/UCP2 Pathway
Abstract: Conclusions: In summary, our study demonstrated that TRPV6 inhibited apoptosis and inflammatory response in the atherosclerosis cell model through the regulation of the PKA/UCP2 pathway.
PubDate: Wed, 23 Oct 2024 13:03:53 +000
- A Network and Pathway Analysis of Genes Associated With Atrial
Fibrillation
Abstract: Conclusions: AF is not only an isolated disease with abnormal electrophysiological activity but might also share a common genetic basis and biological process with tumors and inflammatory diseases as well as cardiovascular diseases. Moreover, the six novel genes inferred from network analysis might help detect the missing AF risk loci.
PubDate: Sat, 05 Oct 2024 06:35:37 +000
- The Bioprotective Effects of Marigold Tea Polyphenols on Obesity and
Oxidative Stress Biomarkers in High-Fat-Sugar Diet-Fed Rats
Abstract: Conclusion: The results clearly indicate that a high dosage of MPT showed antiobesity activity which was comparable to the same effects produced by the conventional drug orlistat.
PubDate: Fri, 04 Oct 2024 09:50:46 +000
- Improved Risk Prediction of Acute Myocardial Infarction in Patients With
Stable Coronary Artery Disease Using an Amino Acid-Assisted Model
Abstract: Patients with stable coronary artery disease (CAD) are at an increased risk of acute myocardial infarction (AMI), particularly among older individuals. Developing a reliable model to predict AMI occurrence in these patients holds the potential to expedite early diagnosis and intervention. This study is aimed at establishing a circulating amino acid-assisted model, incorporating amino acid profiles alongside clinical variables, to predict AMI risk. A cohort of 874 CAD patients from two independent centers was analyzed. Plasma amino acid levels were quantified using liquid chromatography tandem mass spectrometry (LC-MS/MS) employing a targeted metabolomics approach. This methodology incorporated 13C isotope-labeled internal standards for precise quantification of 27 amino acids. Univariate logistic regression was applied to identify differentially expressed amino acids that distinguished between stable CAD and AMI patients. To assess prediction performance, receiver operating characteristic (ROC) curve and nomogram analyses were utilized. Five amino acids—lysine, methionine, tryptophan, tyrosine, and N6-trimethyllysine—emerged as potential biomarkers (), exhibiting significant differences in their expression levels across the two centers when comparing stable CAD with AMI patients. For AMI risk prediction, the base model, utilizing 12 clinical variables, achieved areas under the curve (AUC) of 0.7387 in the discovery phase () and 0.8205 in the external validation set (). Notably, the integration of these five amino acids into the prediction model significantly enhanced its performance, increasing the AUC to 0.7651 in the discovery phase (Delong’s test, ) and to 0.8958 in the validation set (Delong’s test, ). In conclusion, the circulating amino acid-assisted model effectively enhances the prediction of AMI risk among CAD patients, indicating its potential clinical utility in facilitating early detection and intervention.
PubDate: Fri, 30 Aug 2024 10:49:29 +000
- The Effect of Stress Ball on Anxiety and Pain Levels in Angiography: A
Randomized Controlled Trial
Abstract: Conclusion: The application of stress balls during angiography was associated with decreased anxiety and pain levels in patients. Stress ball intervention may serve as a beneficial adjunct to pharmacological treatments. This study underscores the potential of nonpharmacological interventions in enhancing patient comfort during invasive procedures.
PubDate: Sat, 24 Aug 2024 07:33:42 +000
- Discovery and Validation of Potential Serum Biomarkers for Heart Failure
by Untargeted Metabolomics
Abstract: Detection of biomarkers was extremely important for the early diagnosis, prognosis, and therapy optimization of diseases. The purpose of this study was to investigate the differences in serum metabolites between patients with heart failure (HF) and healthy control (HC) and to diagnose HF qualitatively. In this study, serum samples from 83 patients with HF and 35 HCs were used as the research subjects for untargeted metabolomic analysis using ultraperformance liquid chromatography combined with quadrupole-time of flight mass spectrometry (UPLC-QTOF/MS) technology. Potential biomarkers were screened and validated using the orthogonal partial least squares discriminant analysis (OPLS-DA), random forest (RF), binary logistic regression (BLR), and receiver operating characteristic (ROC) analysis. The results indicated that a total of 43 metabolites were considered as differentially expressed metabolites (DEMs). Among these DEMs, glycodeoxycholate was identified as a specific biomarker of HF. A ROC curve analysis for HC versus HF discrimination showed an area under the ROC curve (AUC) of 0.9853 (95% CI: 0.9859–1.0000), a sensitivity of 95%, and a specificity of 100%. Hence, glycodeoxycholate might serve as a potential biomarker for HF. Furthermore, the amino acid metabolism was screened as the most significantly altered pathway in patients with HF. By identifying serum biomarkers and analyzing metabolic pathways, our study provided opportunities to enhance the understanding of the pathogenesis and early diagnosis of HF.
PubDate: Wed, 14 Aug 2024 06:33:54 +000
- Cardiopulmonary Exercise Testing-Guided Exercise Therapy in Hypertensive
Patients: A Single Center Study
Abstract: Conclusion: In addition to drug treatment, cardiac rehabilitation guided by CPET can effectively improve blood pressure control, reduce blood pressure variability, improve cardiorespiratory function and lipid metabolism, and increase exercise endurance in patients with Grade 1 hypertension. Its efficacy is clear and safe, with clinical value for promotion.
PubDate: Thu, 08 Aug 2024 09:37:03 +000
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