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Authors:Dalsgaard; Helene; Dalhoff, Kim Peder; Heerfordt, Ida M. Abstract:Summary Following increasing inquiries to the Danish Poison Information Centre regarding pregabalin and gabapentin, this review investigates existing literature about the addictive potential of these two drugs, with a focus on publications after 2020. A systematic search of PubMed was conducted to identify studies concerning the recreational use, misuse and withdrawal symptoms associated with pregabalin and gabapentin. Five case studies, three observational studies, and two interviews were included. This review highlights demographical variations in the misuse of the drugs. Notably, a high prevalence of recreational use of pregabalin was observed among adolescents often co-ingested with sedatives, such as opioids and alcohol. Withdrawal symptoms often followed abrupt discontinuation even at recommended doses, underscoring the drugs’ potential for physical dependence. This review adds information to the already existing literature and provides new insights into the misuse and abuse of pregabalin and gabapentin. This review supports the need for further monitoring and better patient education to mitigate the rising misuse. PubDate: Thu, 01 Aug 2024 00:00:00 GMT-
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Summary Following increasing inquiries to the Danish Poison Information Centre regarding pregabalin and gabapentin, this review investigates existing literature about the addictive potential of these two drugs, with a focus on publications after 2020. A systematic search of PubMed was conducted to identify studies concerning the recreational use, misuse and withdrawal symptoms associated with pregabalin and gabapentin. Five case studies, three observational studies, and two interviews were included. This review highlights demographical variations in the misuse of the drugs. Notably, a high prevalence of recreational use of pregabalin was observed among adolescents often co-ingested with sedatives, such as opioids and alcohol. Withdrawal symptoms often followed abrupt discontinuation even at recommended doses, underscoring the drugs’ potential for physical dependence. This review adds information to the already existing literature and provides new insights into the misuse and abuse of pregabalin and gabapentin. This review supports the need for further monitoring and better patient education to mitigate the rising misuse.
