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- Maximizing the impact of limited vaccine supply under different early
epidemic conditions: a 2-city modelling analysis of monkeypox virus
transmission among men who have sex with men [Research]-
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Authors:
Knight, J; Tan, D. H. S, Mishra, S.
Abstract: Background:The current global monkeypox virus (MPXV) outbreak has disproportionately affected gay, bisexual and other men who have sex with men (GBMSM). Given that many jurisdictions have been faced with limited supplies of MPXV vaccine, we aimed to explore optimal vaccine allocation between 2 linked GBMSM transmission networks over a short-term time horizon, across several epidemic conditions.Methods:We constructed a deterministic compartmental MPXV transmission model. We parameterized the model to reflect 2 representative, partially connected GBMSM sexual networks ( cities), using 2022 data from Ontario. We simulated a roll-out of 5000 vaccine doses over 30 days that started 45 days after epidemic seeding with 10 imported cases. Within this model, we varied the relative city (network) sizes, epidemic potentials (R0), between-city mixing and distribution of seed cases between cities. For each combination of varied factors, we identified the allocation of doses between cities that maximized infections averted by day 90.Results:Under our modelling assumptions, we found that a limited MPXV vaccine supply could generally avert more early infections when prioritized to networks that were larger, had more initial infections or had greater R0. Greater between-city mixing decreased the influence of initial seed cases and increased the influence of city R0 on optimal allocation. Under mixed conditions (e.g., fewer seed cases but greater R0), optimal allocation required doses shared between cities.Interpretation:In the context of the current global MPXV outbreak, we showed that prioritization of a limited supply of vaccines based on network-level factors can help maximize infections averted during an emerging epidemic. Such prioritization should be grounded in an understanding of context-specific risk drivers and should acknowledge potential connectedness of multiple transmission networks.
Keywords:
Infectious diseases, Epidemiology & epidemiological methods, Public health, Vaccination
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.221232
Issue No: Vol. 194, No. 46 (2022)
- Virtual overdose monitoring services: a novel adjunctive harm reduction
approach for addressing the overdose crisis [Practice]-
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Authors:
Matskiv, G; Marshall, T, Krieg, O, Viste, D, Ghosh, S. M.
Keywords:
Health policy, Family medicine, general practice, primary care, Internal medicine, Innovations, Drugs: pain (including opioids), Vulnerable populations, Addiction medicine
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.220579
Issue No: Vol. 194, No. 46 (2022)
- Tecovirimat for monkeypox [Practice]
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Authors:
Halani, S; Leong, D, Wu, P. E.
Keywords:
Infectious diseases, Pharmacology & toxicology, Family medicine, general practice, primary care, Internal medicine, Five Things to Know About
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.221210
Issue No: Vol. 194, No. 46 (2022)
- Aortitis in a patient on chemotherapy [Practice]
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Authors:
Fukui, S; Kidoguchi, G, Okada, M.
Keywords:
Rheumatology, Pharmacology & toxicology, Cancer & oncology, Drugs: adverse reactions, Internal medicine, Clinical Images
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.220584
Issue No: Vol. 194, No. 46 (2022)
- Beyond wastewater surveillance: refining environmental pathogen detection
in the built environment [Letters]-
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Authors:
Abeygunawardena, S; Kassen, R, Fralick, M.
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.147480-l
Issue No: Vol. 194, No. 46 (2022)
- Clues emerging to mysterious cannabinoid hyperemesis syndrome [News]
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Authors:
Zannese; K.
Keywords:
Emergency medicine, Family medicine, general practice, primary care, Cannabis
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.1096027
Issue No: Vol. 194, No. 46 (2022)
- Gravite de la COVID-19 chez les receveurs dune transplantation dorgane
plein au Canada, 2020-2021 : etude de cohorte prospective multicentrique
[Recherche]-
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Authors:
Hall, V. G; Solera, J. T, Al-Alahmadi, G, Marinelli, T, Cardinal, H, Poirier, C, Huard, G, Prasad, G. V. R, De Serres, S. A, Isaac, D, Mainra, R, Lamarche, C, Sapir-Pichhadze, R, Gilmour, S, Humar, A, Kumar, D.
Keywords:
Recherche
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.220620-f
Issue No: Vol. 194, No. 46 (2022)
- Lhistoire de Vishma : un mystere resolu [Pratique]
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Authors:
Sookdeo, V; Etchells, E, Reich, H. N.
Keywords:
Pratique
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.220302-f
Issue No: Vol. 194, No. 46 (2022)
- Prise en charge de la diverticulite aigue [Pratique]
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Authors:
Zondervan, N; Snelgrove, R, Bradley, N.
Keywords:
Pratique
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.220139-f
Issue No: Vol. 194, No. 46 (2022)
- Papules ombiliquees dans un cas de cryptococcose disseminee [Pratique]
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Authors:
Mitaka, H; Perlman, D. C.
Keywords:
Pratique
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.220354-f
Issue No: Vol. 194, No. 46 (2022)
- Au Canada, la nouvelle normalite necessitera un systeme de detection
ameliore des pathogenes respiratoires emergents et reemergents [Analyse]-
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Authors:
Berry, I; Brown, K. A, Buchan, S. A, Hohenadel, K, Kwong, J. C, Patel, S, Rosella, L. C, Mishra, S, Sander, B.
Keywords:
Analyse
PubDate: 2022-11-27T21:05:16-08:00
DOI: 10.1503/cmaj.220577-f
Issue No: Vol. 194, No. 46 (2022)
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