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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 401 - 253 of 253 Journals sorted alphabetically
Microbial Drug Resistance     Hybrid Journal   (Followers: 3)
Molecular Informatics     Hybrid Journal   (Followers: 5)
Molecular Pharmacology     Hybrid Journal   (Followers: 2)
Molekul     Open Access   (Followers: 1)
Natural Product Communications     Open Access  
Nature Reviews Drug Discovery     Full-text available via subscription   (Followers: 310)
Naunyn-Schmiedeberg's Archives of Pharmacology     Hybrid Journal  
NeuroMolecular Medicine     Hybrid Journal  
Neuropharmacology     Hybrid Journal   (Followers: 5)
Neuropsychopharmacology     Hybrid Journal   (Followers: 17)
Neuropsychopharmacology Reports     Open Access  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Drug Design & Delivery     Open Access  
OA Medical Hypothesis     Open Access  
Obesity Facts     Open Access   (Followers: 8)
Open Pharmacoeconomics & Health Economics Journal     Open Access   (Followers: 1)
Open Pharmacology Journal     Open Access  
OpenNano     Open Access   (Followers: 1)
Orbital - The Electronic Journal of Chemistry     Open Access   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Pain and Therapy     Open Access   (Followers: 3)
Particulate Science and Technology: An International Journal     Hybrid Journal   (Followers: 1)
PDA Journal of Pharmaceutical Science and Technology     Full-text available via subscription   (Followers: 33)
Pediatric Drugs     Full-text available via subscription   (Followers: 3)
Pediatric Pharmacology     Open Access   (Followers: 1)
Pharmaceutica Analytica Acta     Open Access  
Pharmaceutical Biology     Open Access  
Pharmaceutical Care-La Farmacoterapia     Open Access  
Pharmaceutical Chemistry Journal     Hybrid Journal  
Pharmaceutical Development and Technology     Hybrid Journal   (Followers: 19)
Pharmaceutical Executive     Full-text available via subscription   (Followers: 2)
Pharmaceutical Fronts     Open Access   (Followers: 8)
Pharmaceutical Historian     Open Access  
Pharmaceutical Journal     Free   (Followers: 8)
Pharmaceutical Journal of Sri Lanka     Open Access  
Pharmaceutical Medicine     Full-text available via subscription   (Followers: 4)
Pharmaceutical Nanotechnology     Hybrid Journal  
Pharmaceutical Patent Analyst     Full-text available via subscription   (Followers: 3)
Pharmaceutical Research     Hybrid Journal   (Followers: 93)
Pharmaceutical Statistics     Hybrid Journal   (Followers: 15)
Pharmaceutical Technology     Full-text available via subscription   (Followers: 6)
Pharmaceuticals     Open Access   (Followers: 4)
Pharmacia     Open Access  
Pharmaciana     Open Access  
PharmacoEconomics     Full-text available via subscription   (Followers: 25)
PharmacoEconomics & Outcomes News     Full-text available via subscription   (Followers: 2)
PharmacoEconomics German Research Articles     Full-text available via subscription  
PharmacoEconomics Spanish Research Articles     Hybrid Journal   (Followers: 1)
Pharmacoepidemiology and Drug Safety     Hybrid Journal   (Followers: 33)
Pharmacogenetics and Genomics     Hybrid Journal   (Followers: 1)
Pharmacogenomics     Hybrid Journal   (Followers: 7)
Pharmacogenomics and Personalized Medicine     Open Access   (Followers: 2)
Pharmacogenomics Journal     Hybrid Journal   (Followers: 5)
Pharmacognosy Communications     Partially Free  
Pharmacognosy Magazine     Open Access   (Followers: 2)
Pharmacognosy Research     Open Access   (Followers: 2)
Pharmacological Reports     Hybrid Journal  
Pharmacological Research     Hybrid Journal   (Followers: 1)
Pharmacological Research - Modern Chinese Medicine     Open Access  
Pharmacological Reviews     Hybrid Journal   (Followers: 2)
Pharmacology     Full-text available via subscription  
Pharmacology & Therapeutics     Hybrid Journal   (Followers: 3)
Pharmacology & Pharmacy     Open Access   (Followers: 1)
Pharmacology Biochemistry and Behavior     Hybrid Journal   (Followers: 2)
Pharmacology Research & Perspectives     Open Access  
Pharmacon : Jurnal Farmasi Indonesia     Open Access  
Pharmacopsychiatry     Hybrid Journal   (Followers: 3)
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy     Hybrid Journal   (Followers: 37)
Pharmactuel     Open Access   (Followers: 1)
Pharmacy     Open Access   (Followers: 4)
Pharmacy & Pharmacology     Open Access   (Followers: 1)
Pharmacy Education     Full-text available via subscription   (Followers: 11)
Pharmacy Practice (Internet)     Open Access   (Followers: 8)
Pharmakon : Arzneimittel in Wissenschaft und Praxis     Full-text available via subscription   (Followers: 1)
PharmaNutrition     Hybrid Journal   (Followers: 3)
PharmaTutor     Open Access  
Pharmazeutische Industrie     Full-text available via subscription   (Followers: 9)
Pharmazeutische Zeitung     Full-text available via subscription   (Followers: 11)
Pharmazie in Unserer Zeit (Pharmuz)     Hybrid Journal   (Followers: 11)
Physiology International     Full-text available via subscription   (Followers: 3)
Plant Products Research Journal     Full-text available via subscription  
Planta Medica     Hybrid Journal   (Followers: 4)
Planta Medica International Open     Open Access  
Prescriber     Hybrid Journal   (Followers: 9)
Progress in Neuro-Psychopharmacology and Biological Psychiatry     Hybrid Journal   (Followers: 8)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Psychopharmacology     Hybrid Journal   (Followers: 15)
Pulmonary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 2)
PZ Prisma : Materialien zur Fort- und Weiterbildung     Full-text available via subscription  
Redox Report     Open Access  
Regulatory Mechanisms in Biosystems     Open Access   (Followers: 1)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 41)
Research & Reviews : A Journal of Drug Design & Discovery     Full-text available via subscription  
Research & Reviews : A Journal of Pharmaceutical Science     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacognosy     Full-text available via subscription  
Research & Reviews : A Journal of Pharmacology     Full-text available via subscription   (Followers: 1)
Research in Pharmaceutical Sciences     Open Access   (Followers: 3)
Research in Social and Administrative Pharmacy     Hybrid Journal   (Followers: 3)
Research Journal of Pharmacognosy     Open Access  
Research Results in Pharmacology     Open Access  
Reviews of Physiology, Biochemistry and Pharmacology     Hybrid Journal   (Followers: 4)
Reviews on Clinical Pharmacology and Drug Therapy     Full-text available via subscription  
Revista Colombiana de Ciencias Químico-Farmacéuticas     Open Access  
Revista Cubana de Plantas Medicinales     Open Access   (Followers: 1)
Revista de Ciências Farmacêuticas Básica e Aplicada     Open Access  
Revista Mexicana de Ciencias Farmaceuticas     Open Access  
Revue de Médecine et de Pharmacie     Full-text available via subscription  
Safety and Risk of Pharmacotherapy     Open Access   (Followers: 1)
Saudi Pharmaceutical Journal     Open Access  
Scandinavian Journal of Clinical and Laboratory Investigation     Hybrid Journal   (Followers: 7)
Scientia Pharmaceutica     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Seminars in Oncology Nursing     Full-text available via subscription   (Followers: 10)
Separation Science plus (SSC plus)     Hybrid Journal  
Side Effects of Drugs Annual     Full-text available via subscription   (Followers: 2)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 6)
Substance Abuse : Research and Treatment     Open Access   (Followers: 5)
Suchttherapie     Hybrid Journal   (Followers: 1)
Sustainable Chemistry and Pharmacy     Full-text available via subscription   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 5)
SynOpen     Open Access  
The Botulinum J.     Hybrid Journal  
The Brown University Psychopharmacology Update     Hybrid Journal   (Followers: 2)
The Medical Letter     Full-text available via subscription   (Followers: 18)
The Pink Sheet     Full-text available via subscription   (Followers: 12)
The Pink Sheet Daily     Full-text available via subscription   (Followers: 4)
Therapeutic Advances in Drug Safety     Open Access   (Followers: 3)
Therapeutic Advances in Psychopharmacology     Open Access   (Followers: 4)
Therapeutic Advances in Vaccines     Hybrid Journal   (Followers: 1)
Therapeutic Drug Monitoring     Hybrid Journal   (Followers: 3)
Therapeutic Innovation & Regulatory Science     Hybrid Journal   (Followers: 7)
Thérapie     Full-text available via subscription   (Followers: 1)
TheScientist     Free   (Followers: 5)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Toxicological Research     Hybrid Journal  
Toxicological Sciences     Hybrid Journal   (Followers: 11)
Toxicology     Hybrid Journal   (Followers: 18)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 24)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Toxicology in Vitro     Hybrid Journal   (Followers: 11)
Toxicology International     Full-text available via subscription   (Followers: 5)
Toxicology Letters     Hybrid Journal   (Followers: 15)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 7)
Toxicology Research     Partially Free   (Followers: 8)
Toxicon     Hybrid Journal   (Followers: 5)
Toxicon : X     Open Access  
Toxin Reviews     Hybrid Journal  
Translational Psychiatry     Open Access   (Followers: 14)
Trends in Peptide and Protein Sciences     Open Access  
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 19)
Tropical Journal of Pharmaceutical Research     Open Access  
Ukrainian Biopharmaceutical Journal     Open Access  
Vascular Pharmacology     Hybrid Journal   (Followers: 2)
World Mycotoxin Journal     Hybrid Journal   (Followers: 3)
Yakugaku Zasshi     Open Access   (Followers: 1)
Zeitschrift für Phytotherapie     Hybrid Journal   (Followers: 1)
Актуальні питання фармацевтичної та медичної науки та практики     Open Access  
Фармацевтичний часопис     Open Access  

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Asian Journal of Pharmaceutics
Journal Prestige (SJR): 0.144
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0973-8398 - ISSN (Online) 1998-409X
Published by Mandsaur Institute of Pharmacy Homepage  [1 journal]
  • Applications of Novel Drug Delivery Systems for Enhancement
           Bioavailability of Antiretrovirals with Special Focus on Nanotechnology

    • Authors: Dr. S. Sathesh Kumar
      Abstract: Antiretroviral (ARV) therapy is a chemotherapeutic approach to treat viral infections such as AIDS. Remarkable therapeutic strategies improved the mortality rate in HIV patients. However, the neurocognitive disorders associated with HIV is not helmed properly due to the tight blood-brain barrier that restricts majority of ARVs to enter the brain parenchyma through the cerebral capillary endothelium. Conventional formulations are not adequate to reach these needs in the ARV therapy. Moreover, careful monitoring of pharmacokinetic parameters of the ARV drugs is important to achieve utmost therapeutic efficiency. However, the majority of the drugs are confronting this issue due to their poor aqueous solubility and inappropriate tissue permeability. Diversified nanotechnological and varied accustomed approaches were impended using novel polymers (both natural and synthetic) to ameliorate these pharmacokinetic constraints. Ample literature is available about the nanotechnological approaches allude to the development in the field for the enhancement of oral bioavailability, potency with less side effects. Nanotechnological cherishment also helps to control drug resistance and drug abuse. Making sub-micron level drug particles of poor water-soluble ARV drugs revamp the oral bioavailability by amplified surface area, improved interfacial tension at drug and solvent interface. The permeability issues are abolished by tailoring physical structure of the drug particle. Stability in the gastric environment, bypassing the early hepatic metabolism of ARV drugs also can be conquered with nanotechnological contrivances. Among all, nanocarrier, nano vesicular drug delivery system are well-crammed techniques. This review enumerates a detailed picture of bioavailability enhancement techniques for ARV drugs through nanotechnological advents.
      PubDate: 2022-04-20
      DOI: 10.22377/ajp.v16i1.4268
      Issue No: Vol. 16, No. 1 (2022)
       
  • A Cross-sectional Study on the Extended Role of Clinical Pharmacist in
           Assessing the Risk Factors for Developing Diabetic Foot Ulcers among the
           Diabetic Patients

    • Authors: A. Porselvi
      Abstract: A diabetic foot ulcer (DFU) is the prime cause of poor quality of life among diabetic patients. DFU leads to physical disability and an enormous economic burden on diabetic patients. The development and prognosis of DFU are preventable in most patients by modifying the risk factors for DFU. Programs intervened by clinical pharmacists can enhance rational drugs use and improve the early identification and prevention of DFU. This study intended to prove the beneficial outcome in identifying the risk factors and the provision of patient-tailored referral advice regarding DFU among diabetic patients. This cross-sectional study assessed the neuropathy through Michigan Neuropathy Screening Instrument (MNSI), Monofilament and Vibration test using Tuning Fork and Handheld Doppler for assessing the lower limb vascular disease as per NICE guideline among 137 diabetic patients. 64% of patients were found to have symptoms of neuropathy through the neuropathy assessment test whereas 36% did not have the symptoms. Foot sensory using monofilament test was found to be normal in 49.64% of DFU patients, reduced in 43.80%, and absent in 6.57% of DFU patients. The Ankle Brachial Index (ABI) was found to be normal in 48% of patients, mild in 34% of patients, moderate in 12% of patients, and incompressible in 6% of patients. Clinical Pharmacist intervened risk assessment through Hand-held Doppler, MNSI instrument, and Vibration test helped in screening the DFU patients for Neuropathy, and implementation of effective per patient-tailored education was found to be beneficial in the early identification of DFU and referral to specialty hospitals.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4305
      Issue No: Vol. 16, No. 1 (2022)
       
  • Anti-adipogenic Activity of 3-Hydroxyflavone on 3T3-L1 Pre-adipocyte
           Differentiation

    • Authors: Madhavan Sankar
      Abstract: Objective: The study proposed to explore the anti-adipogenic activity of 3-Hydroxyflavone on 3T3-L1 pre-adipocyte differentiation. Method: 3T3-L1 pre-adipocytes were differentiated into adipocytes in the presence of (3, 3 × 102 and 3 × 104 ng/well) 3-Hydroxyflavone for 6 days, the untreated 3T3-L1 pre-adipocytes served as control. After differentiation, the adipocytes were subjected to Oil Red O staining and the m RNA expression of leptin, peroxisome proliferator activated receptor (PPARγ), and the Sterol regulatory element-binding transcription factor 1 (SREBP-1) were studied. Results: A round-shaped adipocytes were appeared in the cultured medium on the 6th day of the study period. The untreated adipocytes showed intense accumulation of the red dye; however, a dose-dependent reversal of red dye accumulation was seen in the adipocytes on 3-Hydroxyflavone exposure. The m RNA expressions of leptin, PPAR γ and SREBP in the untreated adipocytes were significantly up regulated. However, on 3-Hydroxyflavone treatment, the m RNA expressions of leptin, PPAR γ and SREBP in the adipocytes were down regulated in a dose-dependent manner. The high dose (3 × 104 ng per well) of 3-Hydroxyflavone appreciably reduced the oil accumulation and also significantly down regulated the expression of leptin, PPAR γ and SREBP in the adipocytes. Conclusion: The 3-Hydroxyflavone displayed the anti-adipogenic activity in the adipocytes by reducing the oil accumulation and also by down regulating the m RNA expression of leptin, PPAR γ and SREBP, which are need for the adipogensis.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4295
      Issue No: Vol. 16, No. 1 (2022)
       
  • Age-dependence of Poly(Adenosine Diphosphate-Ribos)yl Polymerase 1
           Inhibition in Liver and Thymocyte Nuclei after the Treatment of Rats with
           Cisplatin

    • Authors: Anush Asatryan
      Abstract: Objective: Poly(ADP-ribos)yl polymerase 1 (PARP1) inhibitors enter into clinical trials for mono and combination cancer chemotherapy, improving curative potential of DNA-alkylating agents. It is documented that therapeutic outcomes after the treatment of patients with broad spectrum of drugs are age-dependent and reveal sexual dimorphism. We investigated age- and sex-dependent differences in PARP1 inhibition by benzamide (Bam) and adenosine triphosphate (ATP) in rat liver and thymocyte nuclei after the treatment of rats with cisplatin. Materials and Methods: The drug was injected intraperitoneal. Animals were treated according to the regulations of National Centre of Bioetics (Armenia). Cell nuclei were isolated according to the standard procedure. PARP 1 activity was evaluated by nicotinamide adenine dinucleotide (NAD)+ consumption. Data are expressed as mean ± S.D. Statistical differences in the results between groups were evaluated by the Student’s t-test. A probability (P) value of <0.05 was considered significant. Key results: Basal PARP 1 activity in rat thymocyte and liver nuclei decreases in the period of animal growth from 6 to 10 weeks. The treatment of intact rat with cisplatin differentially affected PARP 1 activity in liver and thymocyte nuclei. It was shown that efficiency of PARP1 inhibition in thymocyte and liver nuclei by Bam and ATP is age-dependent phenomenon which is affected by in vivo treatment of intact rat with cisplatin. It is suggested that the design of personalized combination therapy regimen should consider cisplatin induced age-dependent changes in PARP 1 inhibition by competing/allosteric inhibitors.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4297
      Issue No: Vol. 16, No. 1 (2022)
       
  • The Association between Omeprazole Dosing and Hypomagnesemia in Patients
           with Cardiovascular Disorders

    • Authors: Nermeen Abuelsoud
      Abstract: Background: Patients with acute coronary syndrome should be treated with proton-pump inhibitors (PPIs) to decrease the gastrointestinal complications and hemorrhage associated with antiplatelets use. Hypomagnesemia associated with PPIs is not confirmed yet but if it is confirmed, it may explain the reason of cardiovascular risks associated with PPIs use. Aims: The aims of this study were to determine the association between omeprazole and hypomagnesemia, study the effect of different omeprazole doses in the occurrence of hypomagnesemia, and study the factors that may contribute to this hypomagnesemia. Methods: Over a 1-year period, all patients receiving omeprazole for more than 1 year admitted to the cardiac care unit were enrolled in this study. Patients were divided to three groups according to the omeprazole doses. The association between omeprazole dose and the presence of hypomagnesemia was assessed and compared between the three groups. Results: A total of 105 patients were enrolled in this study. The mean follow-up duration during hospitalization was 5.2 ± 2.9 days. All factors that may affect the incidence of hypomagnesemia were compared between the three groups and there was not any statistically significant difference between the three groups in relation to patient’s age, sex, presence of diabetes mellitus, and concurrent use of digoxin or diuretics. The incidence of hypomagnesemia between the 3 groups was not statistically significant but it was clinically significant. Conclusion: The hypomagnesemia associated with omeprazole may be dose related. This hypomagnesemia may explain the occurrence the cardiovascular events (arrhythmias and sudden death) after omeprazole use, but further studies are needed.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4298
      Issue No: Vol. 16, No. 1 (2022)
       
  • Design and Evaluation of Losartan Potassium Controlled Release
           Microcapsules

    • Authors: Dr. Vidyadhara Suryadevara
      Abstract: Objective: The objective of the present work is to formulate and evaluate Losartan potassium (LP) controlled release microcapsules using gum karaya and polyethylene oxide as polymers, sodium alginate, and calcium chloride as encapsulating material and cross-linking agent. Materials and Methods: LP controlled release microcapsules were prepared by ionic gelation method. The prepared microcapsules were characterized by flow properties such as angle of repose, compressibility index, particle size, and encapsulation efficiency and drug release profiles. Results: All the prepared microcapsules were spherical and exhibited good flow properties. LP is an antihypertensive drug which comes under the class of angiotension antagonist and it was greatly encapsulated with gum karaya and polyethylene oxide (Water soluble resin 303). The Fourier transform infrared spectroscopy and differential scanning calorimetry studies were conducted for pure drug, polymers and optimized formulations, the studies revealed that they were no incompatibilities between drug and polymers used in the present study. Scanning electron microscopy analysis showed that the microcapsules were uniform and spherical in nature with good surface characteristics. Among all the LP controlled release microcapsule formulations. Conclusions: The optimized formulation (L14) prepared with equal proportion of polymers gum karaya and polyethylene oxide was found to extend the release of drug up to 12 h.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4299
      Issue No: Vol. 16, No. 1 (2022)
       
  • Development and Evaluation of Valsartan Fast Disintegrating Films

    • Authors: Dr. T. Balakrishna
      Abstract: Objective: The aim of the present work was to develop and evaluate the fast disintegrating films (FDF) of valsartan which is used for the treatment of hypertension and heart failure. Method: The valsartan fast disintegrating films were prepared by solvent casting method using hydroxylpropyl cellulose, poly vinyl alcohol (PVA), HPMC E5 as film forming agents, Polyethylene glycol 400 as plasticizers and dimethylsulfoxide as penetration enhancer. Results: Valsartan FDF were developed and evaluated for weight uniformity, drug content, film thickness, and folding endurance, the results obtained were within the specified limits. The in vitro diffusion studies were performed using Franz diffusion cell apparatus containing 6.8 pH phosphate buffer as a dissolution media. Conclusion: The FDF prepared with HPMC E5 at 1:3 ratio released the drug up to 98.7% within 5 min which showed the increased solubility, dissolution rate flexibility, and tensile strength of the films when compared to formulation prepared with hydroxypropyl cellulose and PVA. The Fourier-transform infrared studies were conducted for pure drug, polymers and optimized formulation V9 which indicated that were no incompatibilities found between the drug and polymers used in the present studies. Scanning electron microscopy analysis was performed for pure drug, polymers, and optimized formulation V9 which showed that they were no surface fractures and cracks in the films.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4300
      Issue No: Vol. 16, No. 1 (2022)
       
  • Formulation Characterization of Statistically Optimized Naproxen
           Nanocrystals with Quality by Design

    • Authors: Polepalli Sindhuri
      Abstract: Objective: The present objective of the study is to prepare nanoparticles of naproxen and then converting them into a suitable dosage form. Initially, the nanosuspension of naproxen is prepared using anti-solvent precipitation technique. The ideal and best formation obtained with the application of DOE. The best nanosuspension is freeze dried to get nanoparticles which is used for further study. In addition, the various process parameters which have a potential influence on the formulation are also studied. Methods: Solventanti- solvent precipitation method was employed as the preparation technique. A full factorial design (24) is used to design the experiment. Based on the previous studies and literature review, the parameters were selected. The experimental design is designed in such a way to assess various parameters such as critical process parameters, material attributes, and process parameters. Naproxen nanosuspensions were lyophilized with mannitol. The experimental data obtained were subjected to statistical analysis using various methods such as regression and ANOVA. Other evaluation procedures were followed to determine the various characteristics of the formulation and dissolution and pharmacokinetic studies are also performed. Results: The DOE and factorial design showed the point prediction as stirring time of 22.5 min and rate of injection as 0.4 ml/min, solvent-antisolvent ratio of 1:15, and stabilizer drug concentration of 1:7.5. The nanoparticles were found to be intact in SEM/TEM analysis and there were no drug interactions between the formulation ingredients. The zeta potential was found to be 50.2 mv. The pharmacokinetic analysis of nanoparticles showed AUC of 836 ng/ml which is twice obtained with that of pure drug. Other parameters like bioavailability of the formed nanoparticles have improved significantly when compared with that of pure naproxen. Conclusion: Naproxen nanosuspensions have been successfully prepared and the various process parameters which have an effect on the characteristics are studied. The predicted formulation has been prepared and evaluated for various parameters and found pharmacokinetically better when compared to pure drug.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4301
      Issue No: Vol. 16, No. 1 (2022)
       
  • Chronotherapeutic Press-Coated Tablets of Tramadol Hydrochloride: In Vivo
           Evaluation

    • Authors: Ramya Krishna Talakoti
      Abstract: Objective: The purpose of this study is to conduct in vivo pharmacokinetic study of Tramadol Hydrochloride (TH) press-coated tablets (PCTs) in rabbit plasma using reversed-phase high-performance liquid chromatography (RP-HPLC) technique. Materials and Methods: A Phenomenex bond clone reverse phase C18 (4.6 × 150 mm, 5μm) column and mobile phase acetonitrile – 0.01 M phosphate buffer (30:70% v/v) containing 0.1 % triethylamine with 1 ml/min flow rate were used for development and validation of RP-HPLC method, further used to calculate various pharmacokinetic parameters of TH core tablets and PCT in rabbits which received TH core and PCTs. Results and Discussion: The developed method showed a linearity in range of 10–800 ng/ml (r2 = 0.9997), good precision and accuracy with acceptable relative standard deviation values, repeatability, and reproducibility. The drug TH extracted with recovery in range of 96.20–98.29%. The pharmacokinetic study of PCT showed 5 h lag time with drug release. The Cmax and Tmax of core tablet and PCTs were 409.86 ± 40.46 ng/ml at 0.75 h and 289.46 ± 32.58 ng/ml at 10 h, respectively. Area under curve(0-t) of core and PCTs was 1531.26 ± 499.09 ngh/ml and 2293.48 ± 521.8 ngh/ml, respectively. Conclusion: Based on results, PCTs provided better chronotherapeutic release characteristics with drug release after a specified lag time using polymer blend of HPMC E50 and HPMC E100 as release modifiers for therapy of Rheumatoid arthritis.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4302
      Issue No: Vol. 16, No. 1 (2022)
       
  • Design, Optimization, and Characterization of Herbal Face Pack

    • Authors: Saloni Jain
      Abstract: The goal of this project is to develop and test a polyherbal face pack made of herbal substances for cosmetic purposes. Amla (Emblica officinalis), masoordaal (Lens culinaris), and rose petals were obtained from a local market and dried, powdered, then geometrically blended and analyzed for organoleptic and physico-chemical, general powder characteristics, and chemical assessment. The mixed dry powder has an acceptable flow property, making it ideal for use as a face pack. Four distinct compositions incorporating components such as Amla (E. officinalis), masoordaal (L. culinaris), and rose petals powder were developed with variable quantities and called F1 to F4. Different metrics such as organoleptic qualities, physicochemical parameters, and stability, as well as an irritancy test and microbiological load, were used to assess all of the created compositions. The powder’s particle size ranged from 23.3 to 26.9 m. F2 outperformed all other formulations in terms of physical metrics, skin irritation, and consistency even after stable storage conditions.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4304
      Issue No: Vol. 16, No. 1 (2022)
       
  • Recent Approaches of Gastroretentive Drug Delivery System – A Review

    • Authors: Dr. S. Jeganath
      Abstract: The most effective and approved drug delivery method was the oral route. Due to the enormous therapeutic advantages of orally controlled release dosage forms, enhanced medicinal benefits are favored as the important perspective in the pharmaceutical field. Gastroretentive drug delivery system (GRDDS) is an innovative drug delivery method that has an advantage due to its ability to keep extended stomach retention and thus improve drug stomach residence time and also enhance drug bioavailability. Many technological methods, such as swelling and expansion, mucoadhesive, high density, ion exchange, raft forming, magnetic, and floating drug delivery systems, are used to prolong gastric residence time. The objective of this analysis on GRDDSs was to assemble of different gastroretentive approaches that are previously leading methods in the field orally administered controlled release drug delivery.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4273
      Issue No: Vol. 16, No. 1 (2022)
       
  • Role of Topical Flavonoids as Antioxidants to Preserve Healthy Skin
           – A Review

    • Authors: Mrs. Saloni Jain
      Abstract: As a result of the negative effect of some of the horny extract’s associated proteins, the skin is continuously exposed to numerous environmental factors, particularly pollution as well as ultraviolet radiation (UV). As a result, the horny isolate can be adversely affected by the toxic influence of many of its associated proteins. The immediate absorption of UV light through the use of epithelial chromophores, the creation of excited states as well as the subsequent chemical changes, or even photosensitization processes, wherein UV light is absorbed by excited photosensitizer and their responses encourage the production of reactive oxygen species, are all processes that are involved in the environmental pollutants advanced by UV light. Polluting chemicals’ actions are not completely understood, but evidence suggests that one of the key processes involved is oxidative stress caused by lipid peroxidation, which has the potential to cause harm to sebum content, stratum corneum integrity, and skin ageing. Numerous studies have indicated the effectiveness of natural antioxidants, with a focus on natural substances, in promoting the preservation of the skin’s physiological equilibrium.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4274
      Issue No: Vol. 16, No. 1 (2022)
       
 
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