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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 29)
AAPS Open     Open Access   (Followers: 5)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 2)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 96)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 14)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 7)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 6)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 4)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 11)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 5)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 6)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 20)
American Journal of Drug Discovery and Development     Open Access   (Followers: 3)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 51)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 21)
American Journal of Therapeutics     Hybrid Journal   (Followers: 11)
Analytical Methods     Hybrid Journal   (Followers: 7)
Annales Pharmaceutiques Francaises     Full-text available via subscription   (Followers: 1)
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 53)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 27)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 6)
Antibiotics     Open Access   (Followers: 12)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 8)
Archiv der Pharmazie     Hybrid Journal   (Followers: 3)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 1)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Archives of Razi Institute     Open Access   (Followers: 1)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 4)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 5)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 11)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Biochemical Pharmacology     Hybrid Journal   (Followers: 9)
BioDrugs     Full-text available via subscription   (Followers: 4)
Biomaterials     Hybrid Journal   (Followers: 54)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 1)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 6)
Biopharm International     Full-text available via subscription   (Followers: 8)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 12)
BMC Pharmacology     Open Access   (Followers: 3)
BMC Pharmacology & Toxicology     Open Access   (Followers: 5)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 25)
British Journal of Pharmacology     Hybrid Journal   (Followers: 14)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 1)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 12)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical Research in Toxicology     Hybrid Journal   (Followers: 20)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 3)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access   (Followers: 1)
Clinical Drug Investigation     Full-text available via subscription   (Followers: 6)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 11)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 16)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 31)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 2)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 5)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 5)
Clinical Therapeutics     Hybrid Journal   (Followers: 10)
Clinical Toxicology     Hybrid Journal   (Followers: 17)
Clinical Trials     Hybrid Journal   (Followers: 12)
CNS Drug Reviews     Open Access   (Followers: 3)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 6)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 22)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 3)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 5)
Current Drug Metabolism     Hybrid Journal   (Followers: 3)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 2)
Current Drug Therapy     Hybrid Journal   (Followers: 2)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 2)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 7)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 4)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 1)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 6)
Current Therapeutic Research     Open Access   (Followers: 5)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 7)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 1)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 3)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 12)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 7)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 1)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 25)
Drug Development Research     Hybrid Journal   (Followers: 8)
Drug Discovery Today     Full-text available via subscription   (Followers: 63)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 9)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 4)
Drug Metabolism Letters     Hybrid Journal   (Followers: 2)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 3)
Drug Research     Hybrid Journal   (Followers: 1)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 81)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 8)
Drugs     Full-text available via subscription   (Followers: 157)
Drugs & Aging     Full-text available via subscription   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 4)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 2)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 7)
Epilepsy Research     Hybrid Journal   (Followers: 8)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 11)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 5)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 3)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 84)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 23)
European Journal of Pharmacology     Hybrid Journal   (Followers: 3)
European Medical, Health and Pharmaceutical Journal     Open Access   (Followers: 2)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 8)
European Pharmaceutical Journal     Open Access  
European Review for Medical and Pharmacological Sciences     Full-text available via subscription   (Followers: 1)
Experimental and Clinical Psychopharmacology     Full-text available via subscription   (Followers: 6)
Expert Opinion on Drug Delivery     Hybrid Journal   (Followers: 18)
Expert Opinion on Drug Discovery     Hybrid Journal   (Followers: 16)
Expert Opinion on Emerging Drugs     Hybrid Journal   (Followers: 7)
Expert Opinion on Investigational Drugs     Hybrid Journal   (Followers: 10)
Expert Opinion on Orphan Drugs     Hybrid Journal  
Expert Opinion on Pharmacotherapy     Hybrid Journal   (Followers: 7)
Expert Review of Anti-infective Therapy     Full-text available via subscription   (Followers: 5)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 4)
Expert Review of Clinical Pharmacology     Hybrid Journal   (Followers: 2)
Expert Review of Molecular Diagnostics     Full-text available via subscription   (Followers: 5)
Expert Review of Pharmacoeconomics & Outcomes Research     Full-text available via subscription   (Followers: 6)
Expert Review of Precision Medicine and Drug Development     Hybrid Journal   (Followers: 4)
Exploratory Research in Clinical and Social Pharmacy     Open Access   (Followers: 4)
Fitoterapia     Hybrid Journal   (Followers: 5)
Food Additives & Contaminants Part A     Hybrid Journal   (Followers: 8)
Frontiers in Drug Design & Discovery     Hybrid Journal   (Followers: 7)
Frontiers in Medical Technology     Open Access  

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Asian Journal of Pharmaceutics
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0973-8398 - ISSN (Online) 1998-409X
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  • Pharmaceutical Manufacturing Continuous Crystallization Procedures: A
           Review

    • Authors: Sunita N. Vaidya
      Abstract: This academic publication provides an overview of constant crystallization of solutions in the pharmaceutical
      industry. The comparison of continuous versus batch crystallizers, their construction benefits and drawbacks, and
      the addition of solid form framing to create a constantly focused interaction between digital advanced process
      technology technologies and chemical manufacturing functionalities were all covered in detail because of the
      broad key knowledge spectrum of precipitation. In-depth discussion was also given to mechanistic multiscale
      modeling, whose comprehension is crucial for the creation of future control applications. Process simulation and
      crystallizer optimization are also covered in the multiscale modeling section describes the model-based provided,
      which also addresses the intensifying method. Techniques the last section, is taken into consideration. The reader
      can become familiar with research pieces and their outcomes, which have thus far created different emerging
      viewpoints, by reading the unique articles on a particular theme that is gathered, talked about, and contrasted in
      the aforementioned primary categories. The pharmaceutical sector places a lot of emphasis on crystallization,
      and readers may already discover literature on continuous crystallization. However, due to the increasing trend
      towards the synthesis of items with special features that cannot be produced using conventional methodologies,
      the current study has placed a greater emphasis on the construction of automatic control for the generation of
      certain fine chemicals. Continuous crystallization may also allow for intensification techniques, modeling for
      optimization, “on-demand” production, and MPC. A classification study examines the literature.
      PubDate: 2023-10-16
      DOI: 10.22377/ajp.v17i03.4967
      Issue No: Vol. 17, No. 03 (2023)
       
  • Validated Ultraviolet Spectrophotometric Method for Simultaneous
           Estimation of Olmesartan Medoxomil in Marketed Formulation

    • Authors: Dr. Pankaj Sharma
      Abstract: Aim: The goal of the present study is to provide a new, straightforward, and verified UV spectrophotometric technique
      for estimating Olmesartan Medoxomil in commercial formulations like Olmesar 20 and Olmecip 20 (Maclodes
      Pharmaceutical Ltd.). Materials and Methods: Olmesartan Medoxomil is the member of angiotensin receptor blocker
      approved by the Food and Drug Administration for the treatment of hypertension. In oral administration, olmesartan
      medoxomil undergoes intestinal de-esterification to form the active metabolite Olmesartan, which inhibits the binding
      of angiotensin-I (AT-I) to angiotensin-II (AT-II) receptors in vascular muscle. Results and Discussion: Validation
      of created analytical techniques in accordance with Intracerebral hemorrhage scale recommendations. In a 10 ml
      volumetric flask, tablet powder corresponding to 10 mg of olmesartan medoxomil was added. For linearity, accuracy,
      precision, and robustness, 12 distinct concentrations (ranging from 2 to 24 μg/ml) were formed and the calibration plot
      was condensed. Statistical analysis shows that these approaches are reliable and specific for estimating olmesartan
      medoxomil in commercially available tablet formulations. Conclusion: The method outlined for determining olmesartan
      medoxomil in marketed tablet formulations may be effectively used for routine analysis in quality control laboratories.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.5006
      Issue No: Vol. 17, No. 03 (2023)
       
  • Stability Indicating HPTLC Method for Estimation of Tenofovir Disoproxil
           Fumarate in Bulk and Tablet Dosage Form

    • Authors: G. Dharmamoorthy
      Abstract: Objective: A simple, precise, accurate, and rapid validated stability indicating high-performance thin-layer
      chromatography (HPTLC) method for estimation of Tenofovir Disproxil Fumerate was successfully developed.
      Materials and Methods: The method is based on HPTLC separation followed by densitometric measurements
      of their spots at 266 nm. This method is based on HPTLC separation followed by UV detection at 266 nm.
      The separation was carried out on merckTLC aluminum sheets precoated with silica gel 60F254 using a camag
      Linomat 5. Results and Discussion: The mobile consists of Butanol:Ethyl acetate: Acetic acid (4.5:0.5:0.3 v/v).
      Calibration curves were linear in the range of 300–1800 ng/band,respectively Tenofovir disoproxil fumarate gave
      sharp and well-defined peaks at Rf value are 0.51, respectively,stress degradation study shows that sample degraded
      with acid and base hydrolysis, under oxidation, thermal, and photolytic stress conditions. No chromatographic
      interferences from the tablet excipients were found. The method was validated in accordance with the requirements
      of International Conference on Harmonization guidelines Conclusion: Proposed method is precise, selective and
      accurate for the estimation of tenofovir disoproxil fumarate in the bulk and dosage form.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.5007
      Issue No: Vol. 17, No. 03 (2023)
       
  • Box-Behnken Modeling Served for the Development and Optimization of
           Nanoparticles Loaded with Perindopril and Erbumine

    • Authors: Vedanshu Malviya
      Abstract: Background: The study aimed to optimize and validate a nano-particulate technology for the sustained release
      of perindopril erbumine, an angiotensin-converting enzyme (ACE) inhibitor, using a box-behnken experimental
      methodology. Methods: The researcher used a Box-behnken experimental methodology to optimize the
      formulation and assess various characteristics such as particle size, zeta potential, surface shape, encapsulation
      efficiency and in vitro drug release. The nanoparticles characterization findings were recorded included the size,
      polydispersity index, zeta potential and encapsulation efficiency. Results: The nanoparticles had a smooth surface
      and their size was determined to be 122.38 ± 0.75 nm. The polydispersity index was 0.298, the zeta potential
      was 38.79 ± 0.05 mv and the encapsulation efficiency was 61.73 ± 0.06%. In vitro release was restricted for up
      to two hours, but at a pH of 7.4, the rate of drug release increased and was maintained. Conclusion: The study
      concluded that the nano-particulate technology for the potential to improve therapeutic efficacy and decrease
      dosage frequency for drug that need repeated doses such as perindopril erbumine.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.5017
      Issue No: Vol. 17, No. 03 (2023)
       
  • Thermosensitive in situ Otic Gel: A Modern Approach for the Topical
           Management of Otitis Media with Its Formulation Aspects

    • Authors: Prachi A. Shahu
      Abstract: An increasing number of in situ forming systems for many biomedical applications have been published in the
      literature in recent years. Otitis media (OM), most common condition which is caused due to the infection of
      virus and bacteria. Otitis media is classified into two types: acute and chronic. The most often isolated pathogens
      in OM are Streptococcus pneumoniae, non-typeable Haemophilus influenza, and Moraxella catarrhalis. Otalgia,
      ear drainage, fever, restlessness, earache, headache, mild deafness, and difficulty sleeping are all symptoms of
      otitis media. The global impact of Chronic Suppurative OM sickness includes up to 330 million people having
      issue of draining ears, 60% (up to 200 million) have significant hearing difficulty. Thailand had prevalence rates
      ranging from 0.9 to 4.7%, whereas India has a high frequency of 7.8%. Ear drop has drawbacks such as a shorter
      residence time frame in the ear. Semisolid preparation includes drawbacks such as administrative complexity.
      Both of these issues can be solved by developing a solution that forms an in situ gel after administration. Solvent
      exchange, UV-irradiation, ionic cross-linkage, pH alteration, and temperature modulation are few examples of
      the mechanisms. Because it does not involve the use of organic solvents, copolymerization agents, or a locally
      applied gelation trigger, the thermosensitive technique may be desirable for some applications. The benefits of
      in situ polymeric delivery methods include ease of administration and minimized frequency of administration,
      in addition to improved patient compliance and comfort. At body temperature, poloxamer 407 aqueous solutions
      (more than 18% w/v) can produce in situ gel.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4981
      Issue No: Vol. 17, No. 03 (2023)
       
  • Designing and Characterization of Polymeric Microparticles Containing
           Agomelatine-loaded Mesoporous Silica Nanoparticles for a Controlled Drug
           Delivery System

    • Authors: Dr. Suresh Kumar Paswan
      Abstract: Introduction: Depression is a commonly occurring mental disorder distinguished by sadness, lack of interest,
      or pleasure in daily activities. Agomelatine is used in the treatment of depression but suffers short half-life and
      low oral bioavailability. The current research work aims to control the release of drug for longer duration by
      preparing agomelatine-loaded mesoporous silica nanoparticles incorporated into polymeric microparticles for the
      treatment of depression. Materials and Methods: Box-Behnken design was used to optimize agomelatine-loaded
      mesoporous silica nanoparticles prepared by sol-gel method. The drug loading was done by solvent impregnation
      method. The effect of independent variable such as tetraethyl orthosilicate, CTAB, and NaOH 2 M was analyzed
      on dependent variable. Double emulsification solvent evaporation was used to incorporate agomelatine-loaded
      mesoporous silica nanoparticles into ethyl cellulose polymeric microparticles. Results and Discussion: The
      optimized mesoporous silica nanoparticles showed mean particle size of 166.7 nm, 0.367 PDI, 43.3mV zeta
      potential, and 78.03% entrapment efficiency. Optimized mesoporous silica nanoparticles were evaluated for
      FE-SEM, DSC, and XRD. The polymeric microparticles were evaluated for particle size, microscopic evaluation,
      and in vitro drug release. The polymeric microparticles showed 16% initial burst release followed by a continuous
      release pattern for 10 h and exhibited Higuchi model with a regression coefficient(R2) of 0.9287. Conclusion:
      The formulated polymeric microparticles containing agomelatine-loaded mesoporous silica nanoparticles helped
      to improve the oral bioavailability of the drug and controlled its release rate, which lowers the frequency of dose
      and is beneficial for the long-term treatment in case of depression.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4982
      Issue No: Vol. 17, No. 03 (2023)
       
  • Development and Validation of Stability Indicating RP-HPLC Method for
           Pyrimethamine, Sulfadoxine, and Artesunate Estimation in Bulk and Its
           Formulation Applying DOE

    • Authors: Dillip Kumar Dash
      Abstract: Introduction: Artesunate (ART) is a prodrug used as an antimalarial agent that acts by malarial protein
      damage through alkylation. Pyrimethamine (PYR) is an antiprotozoal agent that acts by interfering with the
      synthesis of tetrahydrofolic acid. Sulfadoxine is a dihydropteroate synthetase inhibiter which makes difficulty
      in parasite reproduction. A stability-indicating high-performance liquid chromatography (HPLC) technique
      has been established for the quantification of PYR, sulfadoxin, and ART applying design of experiment.
      Material and Methods: The phosphate buffer (pH 3.0):acetonitrile (80: 20) was used as the mobile phase, and
      hypersil BDS C18 (250 × 4.6 mm; 4 m) column at a flow rate of 1 mL/min was used for the chromatographic
      separation. The detection wavelength was set at 237 nm. The mobile phase was optimized using 32 full factorial
      design. Results and Discussion: The optimized method contains the retention times of PYR, sulfadoxin, and ART
      at 3.653, 4.920, and 8.310 min, respectively. The method shows a good linearity in the concentration range of
      0.5–2.5 μg/mL for PYR, 10–50 µg/mL for sulfadoxin, and 4–20 µg/mL for ART. The stability study of the drugs
      was performed by acid, alkali, oxidation, thermal, and photolytic degradation. Conclusion: The proposed stability
      indicating HPLC method was found to be simple, specific, practical, accurate, quick, and affordable. It was
      also suitable for the routine analysis, quality control, and percentage degradation of pharmaceutical preparations
      containing these drugs either individually or in combination.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4983
      Issue No: Vol. 17, No. 03 (2023)
       
  • Detection and Characterization of Resistant Gene in Tomato Seeds of
           PHS165, Hyveg, and Cynus Hybrid Varieties

    • Authors: Praveen Kumar Vemuri
      Abstract: Background: The demand for tomato is increasing day by day mostly because of the increased per capita fresh
      fruit consumption. Nonetheless, as a perishable fruit crop, it has relatively short life after ripening thus experiences
      remarkable post-harvest losses. Aims: Our approach in this study is to evaluate the consistency and purity of seeds
      that are developed to control pest resistance. Methods: Touchdown polymerase chain reaction (TD-PCR) and
      Fourier transform infrared studies are used to test seed genetic purity of three commercial hybrid tomato seeds
      PHS165, HYVEG, and CYGNUS varieties. TD-PCR is a sensitive and specific method and can be used to detect
      even low levels of genetic impurities. Results: Amplicon of 550bp toward Cry2abresistant gene was found in
      CYGNUS and HYVEG varieties. Results might suggest that these commercial hybrid tomato seeds may contain
      genetic material from Bacillus thuringiensis that confers resistance to Cry2ab toxin. Conclusion: In the present
      study, the purity of tomato hybrid was assessed by both PCR-based and analytical methods-based screening of
      commercial tomato hybrids. Further testing and analysis may be necessary to confirm the presence and origin of
      the Cry2ab-resistant gene in these commercial hybrid tomato seeds and to determine the potential impact on crop
      yield and pest management strategies.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4984
      Issue No: Vol. 17, No. 03 (2023)
       
  • Application of Full 32 Factorial Design in Formulation and Optimization of
           Hydrodynamically Balanced System of Ketorolac Tromethamine

    • Authors: Dr. G. S. Asane
      Abstract: Introduction: The primary objective of this research work was to design a hydrodynamically balanced system
      (HBS) of ketorolac tromethamine based on the combination of swelling and effervescence mechanism that would
      result in minimum floating lag time (FLT), remain buoyant for extended period, and sustain the drug release for
      12 h. Materials and Methods: HBS tablets of ketorolac tromethamine were prepared by wet granulation method
      using 32 full factorial design, where amount of hydroxypropyl methylcellulose K4M (X1) and sodium bicarbonate
      (NaHCO3) (X2) was taken as independent variables. The responses studied were Y1 (hardness), Y2 (FLT), Y3 total
      floating time (TFT), Y4 (swelling index [SI] in pH1.2), and Y5 (t80%) by plotting response surface graph and contour
      plots. Results: The FLT of prepared batches was in the range of 35.24 ± 0.04–116 ± 0.06 s and the minimum FLT
      was shown by OF-9 (35.24 s) batch. The TFT of all batches showed buoyancy and intactness for 24 h. The swelling
      in pH 1.2 at 8 h ranged between 47.80 ± 0.89 and 54.33 ± 0.11 with a significant difference (P < 0.0001). In vitro
      drug release study revealed that more than 95% of drug was released in 12 h and OB-2 showed 10 h to release
      80% of the drug. The analytical characterization revealed the compatibility of drug with excipient and polymers.
      The stability studies performed for 6 months for OF-7 and OF-8 batches showed no change in physicochemical
      properties of drug and there was no significant difference (P < 0.05) in drug release. The response surface graph
      and contour plots showed the effect of variables on responses such as hardness (Y1), SI (Y4), and time taken for
      80% of drug release (t80%)(Y5) which were found to be positively influenced by X1 and ANOVA for response surface
      quadratic model was found to be significant (P < 0.0001). The FLT (Y2) and TFT (Y3) were found to be affected by
      X2
      and ANOVA for the response surface quadratic model was found to be significant (P < 0.05). Conclusion: From
      all the formulations, OF-8 showed ideal results in the form of hardness, FLT, TFT, SI, and time taken for 80% of
      drug release (t80%) and stability based on which it can be selected for in vivo studies.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4985
      Issue No: Vol. 17, No. 03 (2023)
       
  • Molecular Complex of Amlodipine Besylate: Pharmaceutical Characterization
           and Stability Improvisation

    • Authors: Dr. Santosh Ambadas Payghan
      Abstract: The study explains to increase the stability of a drug which is hygroscopic in nature (amlodipine besylate), by
      the molecular complex technique. The stability enhancement achieved using the cocrystallization method by
      the formation of a molecular complex. Saccharin as a coformer is formed by molecular complex. The selection
      of coformer was done based on the Hansen parameter where theoretical value was obtained which gave some
      coformer values and practically molecular complex study was carried out by the solubility method. No any
      interaction between amlodipine besylate and saccharin was confirmed by Fourier transform infrared (FTIR)
      and differential scanning calorimetry (DSC) studies. The stability-enhancing property of cocrystals was carried
      out by short-term accelerated stability studies. To perform stability analysis, few methods of cocrystallization
      were carried out. These cocrystals were evaluated by FTIR, DSC, and powder X-ray diffraction studies. It is
      concluded that the molecular complex of amlodipine besylate with sodium saccharin shows significant stability
      and highlights the use of cocrystallization in stability enhancement. The miscibility of drug and coformers as
      predicated by Hansen solubility parameter, can indicate cocrystal preparation. The resultant δ values of drug and
      coformers are compared and their solid state miscibility is expressed. The possibility of cocrystal formulation by
      krevelens is Δδ < 5 MP and Greenhalgh Δδ < 7 MP
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4986
      Issue No: Vol. 17, No. 03 (2023)
       
  • Large Ring Cyclodextrin and Cosolvency-based Techniques to Improve
           Solubility of Antifungal Drug

    • Authors: Dr. Dipti Gohil
      Abstract: Objective: Posaconazole is used to treat oral candidiasis in patients who are severely immunocompromised.
      Posaconazole is categorized under BCS Class-Ⅱ drug, i.e., low solubility and high permeability. Posaconazole
      has very poor water solubility. The current study aimed to improve water solubility of posaconazole using
      different approaches. Materials and Methods: To enhance the solubility of drug, two methods, inclusion
      complex and cosolvency approach, were performed. In inclusion complex method, beta-cyclodextrin (β-CD)
      and hydroxypropyl β-CD (HP-β-CD) were used for the preparation of inclusion complex. In cosolvency method,
      two different solvents polyethylene glycol-400 (PEG-400) and propylene glycol (PG) were used. Results: The
      inclusion complex of HP-β-CD was prepared by physical mixing, kneading, and solvent evaporation methods
      by taking 1:0.5, 1:1, and 1:2 molar ratio of Drug: HP-β-CD. From the results of dissolution study of complex, it
      was observed that there was no significant improvement in solubility of drug. In cosolvency approach, maximum
      solubility of drug was found in a ratio of 0:100% v/v for both solvents. The solubility of drug in Water: PEG- 400
      and Water: PG solvents were found to be 20.228 ± 0.0169 mg/mL and 17.204 ± 0.0178 mg/mL, respectively.
      Conclusion: In cosolvency method, it was observed that drug has more solubility in PEG- 400 compared to PG.
      Hence, PEG-400 solvent was selected for drug solubilization.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4987
      Issue No: Vol. 17, No. 03 (2023)
       
  • Formulation and Evaluation of Candesartan Cilexetil Fast-Dissolving
           Tablets Using Natural Superdisintegrant

    • Authors: T. Sravani
      Abstract: Introduction: Candesartan Cilexetil is a BCS class II drug having low water solubility, which can be enhanced
      by formulating them in to solid dispersions by using hydrophilic carriers and compressed in to fast dissolving
      tablets by using natural superdisintegrants. Materials and Methods: The solubility and dissolution rate of
      Candesartan Cilexetil were aimed to be increased in this investigation by employing fusion process to create a
      solid dispersion with a hydrophilic carrier like PVP or PEG 6000. Additionally, utilising Croscarmelose sodium
      (CCS) and Aegle marmelos as superdisintegrants, the solid dispersion was compressed into fast dissolving tablets.
      Results and Discussion: The drug release increased proportionately with increase in carrier concentration.
      Among the solid dispersions prepared, the one made with PEG6000 released the medication more rapidly
      than the one made only with PVPK30 and pure drug. First order kinetics were found to determine the release.
      Conclusion: The prepared solid dispersions were then mixed with super-disintegrants like Croscarmelose
      sodium (CCS) and Aegle marmelos to produce tablets. Such tablet formulations have been observed to release
      drug more rapidly than tablets prepared from pure drug. FTIR and XRD tests are used to characterise the pure
      drug and optimised formulation F6. Results showed that there were no drug and excipient interactions.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4988
      Issue No: Vol. 17, No. 03 (2023)
       
  • Simultaneous Determination of Gimeracil, Oteracil, and Tegafur in Pure
           Blend and their Combined Capsules by Stability-indicating RP-UPLC Method

    • Authors: Anusha Kunala
      Abstract: Aim: A trouble-free, simple, specific, and highly sensitive stability indicating phase UPLC method was developed
      for concurrent assessment of Gimeracil, Oteracil and Tegafur in pure and in their combined tablet formulation.
      Method: A separation was accomplished by using X-bridge BEH C18 (100 x 2.1 mm, 2.5 μm) column, mobile
      phase composition of ACN: Buffer (0.5M ammonium formate) (20:80 v/v) and isocratic elution at a flow rate
      of 0.2 mL/min and detection wavelength of 220nm. The extreme stress conditions like hydrolysis with acid and
      base, peroxide oxidation, thermal decomposition was used as per ICH specifications to assess the stability of
      the analytes in bulk and dosage forms. Results and Discussion: The retention times of Gimeracil, Oteracil and
      Tegafur were found at 1.610, 3.502 and 2.985 min. respectively. The proposed method has linear response in the
      concentration ranges from 14.5 to 87 μg/mL, 39.5 to 237 μg/mL and 50 to 300 μg/mL of Gimeracil, Oteracil and
      Tegafur respectively. The LOD and LOQ values were determined as 0.009 μg/mL and 0.026 μg/mL for Gimeracil,
      0.23 μg/mL and 0.69 μg/mL for Oteracil and 0.93 μg/mL and 2.81 μg/mL for Tegafur respectively. The acceptance
      limits of Q2 of the ICH procedures were met by all method validation parameters. The stability of the approach
      may be seen in the fact that the degradation products from forced degradation tests were well-resolved from
      Gimeracil, Oteracil and Tegafur. Conclusion: The suggested RP-UPLC method was very sensitive, exact, stable
      indicator, and cost-effective. Because of this, the method has the potential for use in regular analysis in the quality
      control department as well as pharmaceutical manufacture of Gimeracil, Oteracil and Tegafur.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4989
      Issue No: Vol. 17, No. 03 (2023)
       
  • Cross Clinical Reactivity among Wild Privet and Gaint Hazel Pollinosis

    • Authors: Nadeem Siddiqui
      Abstract: Background: Pollen from various tree and grass species is the most common cause of allergy responses around
      the world. Objectives: In this study, we focused on the allergenic potential and cross-reactivity between pollen
      extracts of Ligustrum robustum and Corylus maxima, aiming to understand the clinical significance of these
      interactions. Several proteins found in Ligustrum pollen have previously been identified as allergens that
      cause sensitization and the onset of allergic symptoms in atopic people. Our study includes the cross-reactivity
      between pollen extracts of L. robustum with C. maxima for clinical significance. Methods: Immunological and
      biochemical characterization was carried out for the purified GST compound which was assessed by sodium
      dodecyl sulfate polyacrylamide gel electrophoresis. The cross-reactivity studies among allergens and relevant
      species were evaluated by enzyme-linked immunosorbent assay inhibition assays. Results: In biochemical assays,
      central goods and services tax (c-GST) was not enzymatically active, whereas l-GST demonstrated high enzymatic
      activity. Conclusion: This research contributes to a better understanding of the allergenic properties and crossreactivity
      patterns between these two pollen sources. The obtained information could have implications for the
      development of diagnostic and therapeutic strategies for individuals with allergies.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4990
      Issue No: Vol. 17, No. 03 (2023)
       
  • Facial Nerve Branching Pattern in the Parotid Region: A Cadaveric Study

    • Authors: Dr. Salah Eldeen Dafalla
      Abstract: Introduction: The present study’s objective was to examine the parotid region’s facial nerve branching pattern.
      One of the 12 pairs of cranial nerves, the facial nerve (VII), travels through the stylomastoid foramen to the parotid
      area. It then passes through the parotid gland’s posteromedial surface. The substance of the parotid gland has a
      complicated branching pattern and divides into five terminal branches. The platysma and face muscles are innervated
      by these branches. Based on the presence of anastomoses or communications between the terminal branches,
      its complicated branching pattern has been divided into many categories. Materials and Methods: Twenty-one
      cadaveric hemi faces were used as a sample, and the dissected specimen photos were photographed. The location
      of the facial nerve division, its relationship to the retromandibular vein, and the number of divisions was all
      documented in the dissected specimens. Results and Discussion: For head-and-neck surgeons, the facial nerve’s
      branching pattern is crucial. The safe removal of the parotid gland without causing facial nerve damage is key to the
      success of the procedure. Conclusion: The success rate of parotid procedures will be impacted by understanding
      of potential anatomical variances. To minimize post-operative problems, medical staff must be aware of these
      variations.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4991
      Issue No: Vol. 17, No. 03 (2023)
       
  • Design, Optimization, and Characterization of Herbal Gel for Facial
           Application

    • Authors: Pankaj Sharma
      Abstract: The objective of this research is to create and test an herbal face gel for cosmetic uses that is comprised natural
      ingredients. A local market was the source of the amla (Emblica officinalis), masoor dal (Lens culinaris), and
      rose petals, which were then dried, powdered, geometrically mixed, and chemically evaluated as well as for
      organoleptic and physicochemical evaluation. Four separate mixtures, designated F1 to F4, were created using
      different ratios of components such E. officinalis, L. culinaris, rose petal powder, and polymers. All of the
      produced compositions were evaluated using a variety of metrics, including preformulation studies, pH, viscosity,
      spreadability, drying time, stability, statistical analysis, and an irritancy test. The viscosity of F1, F2, F3, and F4
      was observed 15101.3 ± 0.55,149 44.9 ± 0.91, 16721.3 ± 0.90, and 16931.5 ± 0.96, respectively, and the pH was
      observed 5.4 ± 0.1, 5.6 ± 0.07, 5.5 ± 0.03, and 5.7 ± 0.1, respectively. The one-way analysis of variance approach
      demonstrated linearity for all answers at P ≤ 0.05.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4992
      Issue No: Vol. 17, No. 03 (2023)
       
  • Infectious Risk in the Sterilization Process for Reusable Medical Devices:
           Preliminary Risk Analysis

    • Authors: Zoubida Khomsi
      Abstract: Background: Patient safety is an area of health care that has emerged with the increasing complexity of health-care
      systems. Indeed, there are several arguments for a comprehensive and coordinated approach to risk management.
      This study determines all probable hazards, which may generate an infectious risk during the different steps of the
      sterilization process. Materials and Methods: The study was conducted from November to December 2019 in
      the central sterilization department of the IBN Sina Hospital in Rabat. The method adopted was the preliminary
      risk analysis (PRA) applied to reusable medical devices (DM) circuits. Results: A total of 38 dangerous situations
      generating an infectious accident were revealed, which will make 38 scenarios. The mapping of hazardous
      situations relating to the different phases of the sterilization process showed 5 types of generic hazards. Among
      these 38 scenarios, 9 are in criticality class 3, 21 situations are in criticality class 2, and 8 scenarios are in criticality
      class 1. After the implementation of risk reduction actions, 31 scenarios remain in criticality 1, 7 in criticality 2,
      and no scenario in criticality 3. Conclusion: The PRA method has enabled all phases of the sterilization process
      to be analyzed and all the probable hazards that could lead to an infectious accident to be identified. The proposed
      risk reduction measures are organizational and educational. After the implementation of these measures, all the
      maximum risks are reduced to a tolerable zone under control, and the average risks are reduced.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4993
      Issue No: Vol. 17, No. 03 (2023)
       
  • Bleomycin and Olaparib Induced Modulation of Poly (ADP-Ribose) Polymerase
           1 Activity and Chromatin Structure in Thymocyte Nuclei

    • Authors: Anush L. Asatryan
      Abstract: Objective: Poly (ADP-ribose) polymerase 1 inhibitors (PARPi) are used in the treatment of cancer patients as
      monotherapy agents or in combination with approved anticancer drugs to optimize their clinical use. However,
      the development of novel anticancer chemotherapy is tempered by the potential detrimental side effects displayed
      by cytotoxic drugs in healthy cells. To delineate the rationality of PARPi olaparib (OLA) in combination with the
      approved DNA-damaging anticancer drug bleomycin (BLM), we investigated the influence of the drugs on poly
      (ADP-ribose) polymerase 1 (PARP 1) activity, chromatin, and DNA structure in healthy rat thymocyte nuclei.
      Materials and Methods: Wistar albino male rats (Rattus norvegicus, 6 weeks old) were used throughout the
      experiments. Animals were obtained from the stock of the animal house of the faculty of biology at YSU. The
      enzymatic assay for PARP 1 activity was performed according to the original method based on the estimation
      of residual NAD+ concentration in the PARP assay mix adapted by us to quantify NAD+ consumed by isolated
      nuclei. DNA concentrations were measured by the spectrophotometric method using an extinction coefficient
      ε260=6600 M-1 cm-1. Statistical differences in results between groups were evaluated by the Student’s t-test. P < 0.05
      was considered significant. Key Results: It was observed that in healthy rat thymocyte nuclei, BLM induced
      PARP-1 inhibition and DNA and chromatin loosening. In contrast, treatment with OLA maintained chromatin and
      DNA condensation, which could partly underlie the cytotoxic effect of OLA as a result of drug-induced downregulation
      of chromatin-associated nuclear functions. Our findings provide evidence for the revalidation of the
      rationality of OLA application in combination chemotherapy regimens involving BLM.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4994
      Issue No: Vol. 17, No. 03 (2023)
       
  • Development and Characterization of Polyherbal Hair Oil for Prevention of
           Hair Fall

    • Authors: Dr. Neeta Rai
      Abstract: Herbs are an essential component of the health-care system in Ayurvedic medicine. In addition to being used in
      medicine, herbs are also used to make a variety of cosmetics and colors, as well as to enhance physical beauty. The
      purpose of the present study is to prepare herbal hair oil from the fresh leaves of different plants. Making herbal hair
      oil with fresh curry leaves, hibiscus flowers, and fenugreek seeds is the goal of the present study. According to the
      Ayurvedic pharmacopeia, the oil was manufactured. Different formulations were made, and the best formulation,
      f2, produced superior results as the pH ranged between 6 and 4.7, whereas f4’s saponification value was discovered
      to be 245.43 and f2’s acid value was 4.7. The prepared herbal hair oil was assessed using a number of criteria,
      including organoleptic qualities, pH, viscosity, acid value, and saponification value. On our forearm, we evaluate
      the prepared compositions for primary skin irritation. The aforementioned criteria were found to be satisfactory
      and within acceptable limits. Of the three concentrations of herbal hair oil created, the third concentration produced
      superior outcomes to the other two. All the values in the evaluation of the finished product showed that they were
      within acceptable limits. Hence, it is concluded that the oil is beneficial in maintaining good hair growth, turning
      grey hairs black, providing protection from dandruff, and resulting in lustrous-looking hair.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4995
      Issue No: Vol. 17, No. 03 (2023)
       
  • Analysis of Little Millets by High-resolution Mass Spectroscopy Focusing
           the Components of Little Millets Effective in the Management of Diabetes
           Mellitus

    • Authors: Prof. K. Ramachandra Reddy
      Abstract: Diabetes mellitus, a metabolic disorder, poses significant health risks. For diabetics, weight loss, exercise, oral
      glucose-lowering medicines, effective diet can help them to achieve adequate glycemic control. Millets contain
      many types of antioxidant elements such as phenolic flavonoids, which are important in controlling glucose levels
      in the body. Taking the millet diet physiologically helps to control the gluconeogenesis process. Little Millet is
      possessing rich antioxidant properties which helps to prevent metabolic and lifestyle disorders such as obesity,
      diabetes, and retinopathy. Through UHPLC-Q-TOF-MS/MS system, major antidiabetic compounds are revealed
      such as hispidin, caffeine, aicar, ketotifen, maltitol, tacrolimus, and pipemidic acid. These compounds indirectly
      control body metabolism to cope-up with diabetes mellitus
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4996
      Issue No: Vol. 17, No. 03 (2023)
       
  • Development and Validation of a New Stability-indicating RP-HPLC Method
           for the Quantification of Etoricoxib in Tablets

    • Authors: Dr. Mukthinuthalapati Mathrusri Annapurna
      Abstract: Introduction: Etoricoxib is also a bipyridine derivative used as a non-steroidal anti-inflammatory drug. A new
      stability-indicating reverse phase high-performance liquid chromatographic (HPLC) method has been developed
      for the quantification of Etoricoxib in tablet dosage forms. Materials and Methods: A Shimadzu HPLC system
      equipped Agilent C18 column was chosen for the chromatographic study with mobile phase formic acid:acetonitrile
      (52:48) and a flow rate of 0.8 mL/min (UV detection at 247 nm). Results and Discussion: Linearity was obeyed
      over the concentration range of 0.5–100 μg/mL with a linear regression equation y = 95013× – 11970 and a
      correlation coefficient of 0.9998. The limit of detection and limit of quantification were found to be 0.1557 and
      0.4791 μg/mL, respectively. Stress degradation studies were performed, and the method was validated as per the
      International Council for Harmonisation guidelines. Conclusion: The RP-HPLC method so developed was found
      to be selective, specific, precise, accurate, robust, and useful for the estimation of Etoricoxib tablets.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4997
      Issue No: Vol. 17, No. 03 (2023)
       
  • Formulation Development and Evaluation of Tablet in Tablet Dosage form to
           Proffer a Quick and Protracted Relief in Gastritis and Allied Gastric
           Disorders

    • Authors: Kapil Kanwar
      Abstract: Purpose: The contemporary investigation was intended to extend and appraise uniqueness of the tablet in tablet
      formulation with a perception to proffer a quick and protracted relief in gastritis and allied gastric disorders.
      Materials and Methods: The possible drug-excipient interaction between Esomeprazole Magnesium and
      formulation constituents/excipients of core and outer tablet was envisaged to map the batch composition formulas
      for the core tablets. The core tablets were compressed using 6.5 mm die punch (concave) set and outer tablets
      (devoiding core tablet) were compressed using 14 mm die punch (concave) set with optimized compression load
      and speed. Based on performance outcome of core tablet and outer tablet batches, during the assessment of the
      post compression parameters, three batches for tablet in tablet were purposed and compacted, which were later
      subjected to in vitro release kinetics. The short-term accelerated stability testing of the varied batches of tablet in
      tablet formulations was executed to predict the environmental influence over the quality of finalized formulation
      and to ensure that no alteration has been brought in to the formulation during the course of manufacturing process
      that could negatively impact its stability. The optimized tablet in tablet formulation was compared with the
      commercially accessible enteric coated Esomeprazole tablet. The maximum plasma concentration (Cmax, μg/mL)
      and the corresponding time (Tmax, hour) for the two treatments in each rabbit were estimated through highperformance
      liquid chromatography in the plasma concentration data. Results: The post-compression parameters
      of the core tablets revealed that the CT-26 batch, comprising polyethylene glycol as binder and sodium starch
      glycolate as disintegrant, was best among rest, of all the batches (CT-1 to CT-27), with crushing strength of 3.57
      ± 0.115 kg/cm2, Friability 0.188 ± 0.002 (% loss), disintegration time of 52.66 ± 0.57 s, and % drug content
      was found to be 100.31 ± 0.32. The post-compression parameters of outer tablet, reveals that the OT-2 batch,
      comprising microcrystalline cellulose as disintegrant, was best among rest, out of all batches (OT-1 to OT-9), with
      crushing strength of 5.55 ± 0.132 kg/cm2, Friability 0.098 ± 0.004 (% loss), and disintegration time of 161.33
      ± 0.57 s. The analysis of the entire tablet in tablet (T in T-1 to T in T-3) batches reveals that of the T in T -3
      (comprising of CT-26 and OT-2) was the best batch, among rest of all batches (T in T-1 to T in T-3), with mean
      weight 776.95 ± 0.394 mg, thickness 6.516 ± 0.028 mm, crushing strength of 6.10 ± 0.276 kg/cm2, Friability 0.193
      ± 0.006 (% loss), disintegration time of 189.33 ± 0.577 s, and % drug content 97.36 ± 0.07. The in vitro release of
      Esomeprazole magnesium from varied tablet in tablet formulations were also assessed by integrating drug release
      statistics into diverse release pharmacokinetics models. The maximized regression values (0.991) for tablet in
      tablet formulations demonstrated the sensible linearity through Higuchi pharmacokinetic model, signifying the
      formulations as modified release formulation.The accelerated stability studies have demonstrated the consistent
      sunset yellow color of the optimized formulation, with smooth surface exclusive of any flaws or cracks. The
      disintegration time of 195.21 ± 1.468 s, and % drug content was found to be 96.79 ± 0.53Conclusion: In the present study, the tablet in tablet
      technology was used to formulate an immediate release formulation, in which Esomeprazole Magnesium; an acid labile drug
      was kept in core tablet and the outer tablet confining acid neutralizing agents. The constituents of core tablet and outer tablet
      release simultaneously in the stomach acidic environment. The outer tablet containing acid neutralizing agents counterbalance
      the gastric environment and thus providing favorable pH environment for the release of esomeprazole in stomach. Both the
      constituents act in synergy to produce desired pharmacological action. This will provide instantaneous relief with the release of
      acid neutralizing agents from the outer tablet and proffer prolong relief (with the release of esomeprazole from the core table)
      from the gastric symptoms due to irreversible binding to cysteine residues of the H+/K +ATPase. The clinical action of each drug
      component will not alter and exhibited their action in synergy. This will offer better therapeutic efficacy and improve patient
      compliance.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4998
      Issue No: Vol. 17, No. 03 (2023)
       
  • Formulation, Evaluation, and Comparison of Herbal Shampoo with
           Commercially Available Shampoos

    • Authors: Mr. Umesh B. Telrandhe
      Abstract: Introduction: A shampoo is essentially a detergent solution with appropriate ingredients for additional advantages
      such as improved hair conditioning, lubrication, and medicine. There are many different types of shampoos on the
      market today; including synthetic, herbal, medicated, and non-medicated varieties, but herbal shampoo is becoming
      more and more popular among customers due to their perception that natural goods are risk-free and without
      adverse effects. Aim: The aim of the present study is to formulate herbal shampoo, and evaluate and compare
      its physicochemical properties with the commercially available shampoos. Materials and Methods: The herbal
      shampoo was formulated by adding the extracts of Calendula officinalis, Lawsonia inermis, Citrus limonum, Citrus
      ulgaric, and Santolina trifoliatus in different proportions to a 10% aqueous gelatin solution. Small amount of
      methylparaben was added as a preservative and pH was adjusted with citric acid. Several quality control tests
      such as physical appearance/visual inspection, pH, solid contents, foam test, viscosity test, dirt dispersion test,
      surface tension, wetting test, and conditioning performance tests were performed to determine the physicochemical
      properties of formulated herbal shampoo and commercial shampoos. The formulated herbal shampoo and
      commercial shampoo were also evaluated for conditioning performance by blind test on twenty volunteers.
      Results and Discussion: The results revealed that our formulated herbal shampoo was transparent. The results
      showed good cleansing and detergency, normal pH, low surface tension, small bubble size, good viscosity, and
      foam stability after 5 min. The formulated shampoo and commercial shampoos also showed comparable results for
      % solid contents. The score of the conditioning performance of the tress washed with herbal shampoo was found to
      be 3.2 out of 4, while the score of the commercial shampoo was 3.1 and 3.3, respectively. Conclusion: Our results
      revealed that the formulated herbal shampoo has excellent conditioning performance, at par with commercially
      available shampoo. However, further research and development is required to improve its quality and safety.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4999
      Issue No: Vol. 17, No. 03 (2023)
       
  • Thermal Conductivity of the Body in Students from Kyrgyzstan, India and
           China

    • Authors: Yethindra Vityala
      Abstract: Background: According to physicists, thermal conductivity (k) refers to the rate at which thermal energy and the interaction
      of microparticles transfer energy from warmer to colder parts of the body. To maintain body temperature homeostasis under
      changing conditions in the external or internal environment, macroscopic organisms should differ in their k of the body. The
      objective of the study is to evaluate the k of the body in students from Kyrgyzstan, India, and China. Materials and Methods:
      In this study, 600 students from various racial and ethnic groups attended institutions in Bishkek, Kyrgyzstan, including 200
      students from each of the following groups: Kyrgyz, Indian, and Chinese. The Kyrgyz and Indian (Uttar Pradesh and Punjab,
      India) students from the Kyrgyz State Medical Academy, the International Higher School of Medicine, and the Chinese
      (Guangzhou Province, China) students from the Kyrgyz Pedagogical University in Bishkek, Kyrgyzstan, were studied to
      determine if race or ethnicity could affect the k of the body. Results: There were significant differences between the values of
      k among the students of India and China, Kyrgyzstan and China, while the alleged relationship between Indians and Kyrgyz
      did not appear which indicates a possible similarity between the k of the bodies of two nationalities. Conclusion: Variation
      was observed in the k of various national groups in comparison to one another. The Kyrgyz and Indian students have a
      similar distribution of k values, but the Chinese students have a distinct pattern.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.5000
      Issue No: Vol. 17, No. 03 (2023)
       
  • Assessment of Antioxidant and Anti-inflammatory Activities of Probiotic
           Lactiplantibacillus plantarum Strains Isolated from Traditional Fermented
           Food Products Ngari and Soibum

    • Authors: Shubha Gopal
      Abstract: Introduction and Aim: Lactic acid bacteria (LAB) with remarkable functional properties have been isolated from
      different fermented food products. Ngari and soibum are fermented fish and fermented bamboo shoot products
      produced in Manipur, India. The present study was conducted to isolate potential probiotic strains from ngari and
      soibum also to evaluate their antioxidant and anti-inflammatory activities. Materials and Methods: LAB strains
      were isolated from ngari and soibum samples, characterized, and evaluated for probiotic properties including
      acid and bile tolerance, antimicrobial activity, antibiotic susceptibility, and hemolytic activity. The strains were
      identified by 16S rRNA gene sequencing. Two strains with the best probiotic potential were selected and evaluated
      for antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2-Azino-bis-(3-ethylbenzothiazoline-6-
      sulfonic acid) diammonium salt (ABTS) radical scavenging assays and anti-inflammatory activity by real-time
      polymerase chain reaction. Results: The isolates were capable of surviving in an environment with low pH (pH 2)
      and with bile salts (0.3% oxgall). The cell-free supernatant of the isolates showed high antibacterial activity
      against the tested pathogens. The isolates were sensitive to most of the test antibiotics and none of the isolates
      showed hemolytic activity. By 16S rRNA gene sequencing, the isolates were identified as Lactiplantibacillus
      plantarum (five strains) and Enterococcus faecium (one strain). L. plantarum strains NG28 and SB15 exhibited
      high antioxidative capacity in terms of DPPH and ABTS radical scavenging assays. These two strains were
      also capable of reducing the production of nitric oxide as well as the expression of nitric oxide synthase and
      cyclooxygenase-2 as well as pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, and
      IL-6 in lipopolysaccharide-induced RAW 264.7 cells. Conclusion: The selected LAB strains possess the potential
      probiotic and beneficial functional properties. Hence, they could be used in functional foods and pharmaceutical
      applications.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.5001
      Issue No: Vol. 17, No. 03 (2023)
       
  • An Overview of Regulatory Guidelines for Medical Gases

    • Authors: K. Venkateswara Raju
      Abstract: Direct administration or supply of medical gases to patients is dangeous. Regulatory guidance requirements
      of various regulatory agencies, the highest quality should be used in their manufacture and transfer. The
      manufacturer of medical gases requires a license or regulatory approval to manufacture the gases; thus, they
      must maintain the quality of the gases in accordance with standards or quality limitations established by the
      drug regulatory authorities. Medicinal gases are manufactured, packed, and designed for patient administration
      during anesthesia, therapy, or diagnostics. Oxygen, helium, carbon dioxide, nitrous oxide, medicinal air, and
      nitrogen are officially recognized therapeutic gases. These gases are usually administered preoperatively,
      intraoperatively, and postoperatively in surgical patients. This gas ignites supplied in an airtight, color-coded,
      and properly labeled container as required by the relevant regulatory authorities in each country or through
      the central line runs all over the hospital. Despite all the rules, they are reports on problems related to the
      production and use of medical gases. In this study, we tried to give a brief overview of regulatory guidelines
      for medical gases in India and USA.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4974
      Issue No: Vol. 17, No. 03 (2023)
       
  • Microspheres as a Unique Drug Carrier for Controlled Drug Delivery: A
           Review

    • Authors: Vaishnavi S. Shete
      Abstract: Comparing such systems to conventional administrative approaches, they may offer a numeral benefit.
      Controlled distribution of drugs can solve the problems of traditional medicine and improve medicine resources.
      Microspheres (MS) are generally free-flowing powders made of proteins or synthetic polymers with a particle size
      of 1–1000 mm. The literature search was accomplished using PubMed, Science direct, Google scholar, and the
      Cochrane library to recognize appropriate scientific articles. The search terms included controlled drug delivery
      systems, MS as drug carrier, advantages of MS, types of MS, importance of MS, different formulation techniques
      of MS, evaluation techniques of MS, and applications of MS.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4975
      Issue No: Vol. 17, No. 03 (2023)
       
  • A Review of Hypermobile Ehlers-Danlos Syndrome

    • Authors: P. Dharani Prasad
      Abstract: Ehlers-Danlos syndrome (EDS) is a rare connective tissue disorder that affects the collagen metabolism in
      which collagen deficiency occurs. According to the 2017 international classification of the EDS, 13 different
      subtypes are caused by pathogenic variants in 19 different genes that encode collagen and collagen-modifying
      proteins. Among the 13 subtypes of EDS, hypermobile EDS (hEDS) is the most common one. hEDS is
      formerly known as type III EDS. The cause of hEDS is idiosyncratic. Inheritance is autosomal dominant. The
      patients of hEDS have softness, stretchiness, fragility, bruisability, and poor wound healing when compared
      to normal patient. Hernias may also be more common in persons with hEDS who undergo abdominal surgery,
      such as laparotomy or C-section. Symptoms of hEDS include soft and elastic or stretchy skin, easy bruises,
      and persistent musculoskeletal pain. Three disease phases were proposed in a 2010 study: A “hypermobility”
      phase, a “pain” phase, and a “stiffness” phase. The prevalence rate of hEDS is 80–90% of all the cases of
      EDS. The cause of hEDS, which has a genetic inheritance pattern similar to Alzheimer’s disease, is not
      known to be a gene mutation. The treatment of hEDS depends on signs and symptoms present in each
      patient, and treatment differs from patient to patient. There is no particular treatment for hEDS, and physical
      therapy is often recommended to strengthen muscles and improve joint stability. Pain medication such as
      physiotherapy, occupational therapy, orthopedic instruments, aquatic therapy, and cognitive behavioral
      therapy.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4976
      Issue No: Vol. 17, No. 03 (2023)
       
  • Review: A Perspective Use and Misuse of Antibiotics

    • Authors: P. Dharani Prasad
      Abstract: Antibiotics are the most active chemotherapeutics among drugs; they exert their therapeutic effect by antagonizing
      the growth of bacteria. Since 1910 many antibiotics have been developed with different mechanisms of action
      including: (1) Inhibition of bacteria’s cell wallsynthesis; this class of antibiotics includes vancomycin and
      β-lactam antibiotics such aspenicillins, cephalosporins, and carbapenems, (2) inhibition of protein synthesis
      including tetracyclines, aminoglycosides, macrolides, and chloramphenicol, and (3) DNA synthesis inhibitors
      such as fluoroquinolones and sulfonamides that inhibit folic acid synthesis. In this chapter, we describe the three
      antibiotic classes, their mechanism of action, clinical uses, side effects, and their resistance by different bacteria
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4977
      Issue No: Vol. 17, No. 03 (2023)
       
  • Current Surgical Interventions for Treating Tuberculosis: Exploring the
           Benefits and Risks

    • Authors: Sunil Kardani
      Abstract: The main organs affected by the chronic infectious disease tuberculosis (TB) are the lungs. Although the main form
      of therapy for TB is medicinal, surgical intervention may be necessary if the disease is localized to a particular
      area of the lung and cannot be effectively treated with medicines alone. Segmentectomy, pneumonectomy, and
      lobectomy are the three primary surgical procedures used to treat TB, and video-assisted thoracoscopic surgery, a
      minimally invasive technique, enables the removal of the diseased tissue. The surgical removal of one of the five
      lung lobes is known as a lobectomy. When TB is limited to one lobe of the lung and cannot be adequately treated
      with medication alone, surgery is often undertaken. Candidates for lobectomy include patients with cavitary lesions
      larger than 4 cm, a persistent cough, fever, hemoptysis, bronchopleural fistula, or localized abscess formation. The
      risk of problems can be reduced with appropriate pre-operative assessment, surgical technique, and post-operative
      care. The surgical removal of the complete lung is known as a pneumonectomy. It is normally saved for TB cases
      where medicine is ineffective and the disease has spread to affect a significant area of the lung. Pneumonectomy
      may be an option for patients who have severe cavitary lesions, extensive lung damage, considerable main
      bronchus involvement, or consequences including bronchopleural fistula, severe hemoptysis, or localized abscess
      formation. Similar to lobectomy, the risk of problems can be reduced with good pre-operative assessment, surgical
      technique, and post-operative care. A segment of a lung lobe is surgically removed, a procedure known as a
      segmentectomy or partial lobectomy. When TB is confined to a particular area of the lung and cannot be properly
      treated with drugs alone, surgery may be an option. Segmentectomy may be beneficial for patients with a tiny
      cavitary lesion, localized fibrosis, or a cavitary lesion that cannot be removed in the upper lobe of the lung or who
      are unable to have more comprehensive surgery. Once more, minimizing the risk of problems can be achieved
      through good pre-operative assessment, surgical technique, and post-operative care.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4968
      Issue No: Vol. 17, No. 03 (2023)
       
  • Nose to Brain Drug Delivery: A Directed Approach for Delivering Drug into
           Brain

    • Authors: Dr. Mangesh D. Godbole
      Abstract: Poor/delayed bioavailability and hepatic first pass metabolism are the major concern when most common oral
      route is chosen for the delivery of drug, which is why alternate therapies are constantly sought for. Oral route
      known to have first dissolution of drugs in stomach followed by absorption in systemic circulation which may lead
      to delay in the effect of drug and reduce the efficacy and potency of the drug. When it is a matter of targeting to
      the brain, less lipophilic drugs have limited accessibility to the brain and thereby delays therapeutic effect. These
      limitations about brain targeting system suggest the requirement for the development of delivery system that will
      transport the medication in to the brain with adequate concentration to get pharmacological action. Drug delivery
      to brain through nasal mucosa is nowadays emerging way of transport of drug. This method devotes of first pass
      effect, improves absorption and requires minimal dose. Nasal in situ gel, after administration, converts rapidly
      into gel from liquid after contact with nasal mucosal region allowing adhering of drug in to nasal region. Nasal
      epithelium allows molecular mass up to 500 Da to pass and thus, the rapid drug accumulation in brain. This review
      focuses on nasal administration of medicines as a new method of drug transport into the brain. The mechanism of
      drug absorption through the mucous membrane of the nose, different types of nasal drug administration, methods
      of production, and polymers required are all described in this paper.
      PubDate: 2023-09-15
      DOI: 10.22377/ajp.v17i03.4969
      Issue No: Vol. 17, No. 03 (2023)
       
 
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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 29)
AAPS Open     Open Access   (Followers: 5)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 2)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 96)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 14)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 7)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 6)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 4)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 11)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 5)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 6)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 20)
American Journal of Drug Discovery and Development     Open Access   (Followers: 3)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 51)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 21)
American Journal of Therapeutics     Hybrid Journal   (Followers: 11)
Analytical Methods     Hybrid Journal   (Followers: 7)
Annales Pharmaceutiques Francaises     Full-text available via subscription   (Followers: 1)
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 53)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 27)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 6)
Antibiotics     Open Access   (Followers: 12)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 8)
Archiv der Pharmazie     Hybrid Journal   (Followers: 3)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 1)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Archives of Razi Institute     Open Access   (Followers: 1)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 4)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 5)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 11)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Biochemical Pharmacology     Hybrid Journal   (Followers: 9)
BioDrugs     Full-text available via subscription   (Followers: 4)
Biomaterials     Hybrid Journal   (Followers: 54)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 1)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 6)
Biopharm International     Full-text available via subscription   (Followers: 8)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 12)
BMC Pharmacology     Open Access   (Followers: 3)
BMC Pharmacology & Toxicology     Open Access   (Followers: 5)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 25)
British Journal of Pharmacology     Hybrid Journal   (Followers: 14)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 1)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 12)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical Research in Toxicology     Hybrid Journal   (Followers: 20)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 3)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access   (Followers: 1)
Clinical Drug Investigation     Full-text available via subscription   (Followers: 6)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 11)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 16)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 31)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 2)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 5)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 5)
Clinical Therapeutics     Hybrid Journal   (Followers: 10)
Clinical Toxicology     Hybrid Journal   (Followers: 17)
Clinical Trials     Hybrid Journal   (Followers: 12)
CNS Drug Reviews     Open Access   (Followers: 3)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 6)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 22)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 3)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 5)
Current Drug Metabolism     Hybrid Journal   (Followers: 3)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 2)
Current Drug Therapy     Hybrid Journal   (Followers: 2)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 2)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 7)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 4)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 1)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 6)
Current Therapeutic Research     Open Access   (Followers: 5)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 7)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 1)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 3)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 12)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 7)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 1)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 25)
Drug Development Research     Hybrid Journal   (Followers: 8)
Drug Discovery Today     Full-text available via subscription   (Followers: 63)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 9)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 4)
Drug Metabolism Letters     Hybrid Journal   (Followers: 2)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 3)
Drug Research     Hybrid Journal   (Followers: 1)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 81)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 8)
Drugs     Full-text available via subscription   (Followers: 157)
Drugs & Aging     Full-text available via subscription   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 4)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 2)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 7)
Epilepsy Research     Hybrid Journal   (Followers: 8)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 11)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 5)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 3)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 84)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 23)
European Journal of Pharmacology     Hybrid Journal   (Followers: 3)
European Medical, Health and Pharmaceutical Journal     Open Access   (Followers: 2)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 8)
European Pharmaceutical Journal     Open Access  
European Review for Medical and Pharmacological Sciences     Full-text available via subscription   (Followers: 1)
Experimental and Clinical Psychopharmacology     Full-text available via subscription   (Followers: 6)
Expert Opinion on Drug Delivery     Hybrid Journal   (Followers: 18)
Expert Opinion on Drug Discovery     Hybrid Journal   (Followers: 16)
Expert Opinion on Emerging Drugs     Hybrid Journal   (Followers: 7)
Expert Opinion on Investigational Drugs     Hybrid Journal   (Followers: 10)
Expert Opinion on Orphan Drugs     Hybrid Journal  
Expert Opinion on Pharmacotherapy     Hybrid Journal   (Followers: 7)
Expert Review of Anti-infective Therapy     Full-text available via subscription   (Followers: 5)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 4)
Expert Review of Clinical Pharmacology     Hybrid Journal   (Followers: 2)
Expert Review of Molecular Diagnostics     Full-text available via subscription   (Followers: 5)
Expert Review of Pharmacoeconomics & Outcomes Research     Full-text available via subscription   (Followers: 6)
Expert Review of Precision Medicine and Drug Development     Hybrid Journal   (Followers: 4)
Exploratory Research in Clinical and Social Pharmacy     Open Access   (Followers: 4)
Fitoterapia     Hybrid Journal   (Followers: 5)
Food Additives & Contaminants Part A     Hybrid Journal   (Followers: 8)
Frontiers in Drug Design & Discovery     Hybrid Journal   (Followers: 7)
Frontiers in Medical Technology     Open Access  

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