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  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 24)
AAPS Open     Open Access   (Followers: 4)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 3)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 93)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 9)
Advances in Pharmacology     Full-text available via subscription   (Followers: 17)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 5)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 5)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 8)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 9)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 20)
American Journal of Drug Discovery and Development     Open Access   (Followers: 3)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 54)
American Journal of Pharmacological Sciences     Open Access   (Followers: 1)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 23)
American Journal of Therapeutics     Hybrid Journal   (Followers: 13)
Analytical Methods     Hybrid Journal   (Followers: 8)
Annales Pharmaceutiques Francaises     Full-text available via subscription  
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 56)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 36)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 5)
Antibiotics     Open Access   (Followers: 11)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 8)
Applied Clinical Trials     Full-text available via subscription   (Followers: 7)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 2)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 1)
Archives of Razi Institute     Open Access  
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Pharmaceutics     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Pharmaceutical Journal     Full-text available via subscription  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 14)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Bioanalysis     Full-text available via subscription   (Followers: 11)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
BioDrugs     Full-text available via subscription   (Followers: 8)
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 3)
Biomarkers in Drug Development     Partially Free   (Followers: 2)
Biomaterials     Hybrid Journal   (Followers: 55)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 1)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 9)
Biopharm International     Full-text available via subscription   (Followers: 20)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 10)
BMC Pharmacology     Open Access   (Followers: 2)
BMC Pharmacology & Toxicology     Open Access   (Followers: 8)
Brazilian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 30)
British Journal of Pharmacology     Hybrid Journal   (Followers: 17)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 2)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical and Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 1)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 22)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Ciencia e Investigación     Open Access  
Ciência Equatorial     Open Access  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 7)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access  
Clinical Drug Investigation     Full-text available via subscription   (Followers: 8)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 12)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 28)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 45)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 4)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 6)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 12)
Clinical Therapeutics     Hybrid Journal   (Followers: 34)
Clinical Toxicology     Hybrid Journal   (Followers: 18)
Clinical Trials     Hybrid Journal   (Followers: 18)
CNS Drug Reviews     Open Access   (Followers: 4)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 11)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Therapeutic Drug Carrier Systems     Full-text available via subscription   (Followers: 5)
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 25)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 4)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 6)
Current Drug Metabolism     Hybrid Journal   (Followers: 5)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 5)
Current Drug Therapy     Hybrid Journal   (Followers: 3)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 13)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 9)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 10)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 11)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 2)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 1)
Current Therapeutic Research     Open Access   (Followers: 6)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 8)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 4)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 5)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 13)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 8)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 3)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 29)
Drug Development Research     Hybrid Journal   (Followers: 11)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 12)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 13)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 6)
Drug Metabolism Letters     Hybrid Journal   (Followers: 3)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 8)
Drug Research     Hybrid Journal   (Followers: 3)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 79)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 10)
Drugs     Full-text available via subscription   (Followers: 123)
Drugs & Aging     Full-text available via subscription   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs and Therapy Studies     Open Access  
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 8)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Egyptian Pharmaceutical Journal     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access  
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 9)
Epilepsy Research     Hybrid Journal   (Followers: 7)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 14)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 8)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 84)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 34)
European Journal of Pharmacology     Hybrid Journal   (Followers: 8)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 9)
European Review for Medical and Pharmacological Sciences     Full-text available via subscription   (Followers: 1)
Experimental and Clinical Psychopharmacology     Full-text available via subscription   (Followers: 7)
Expert Opinion on Drug Delivery     Hybrid Journal   (Followers: 17)
Expert Opinion on Drug Discovery     Hybrid Journal   (Followers: 18)

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Asian Journal of Pharmaceutics
Journal Prestige (SJR): 0.144
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0973-8398 - ISSN (Online) 1998-409X
Published by Mandsaur Institute of Pharmacy Homepage  [1 journal]
  • Applications of Novel Drug Delivery Systems for Enhancement
           Bioavailability of Antiretrovirals with Special Focus on Nanotechnology

    • Authors: Dr. S. Sathesh Kumar
      Abstract: Antiretroviral (ARV) therapy is a chemotherapeutic approach to treat viral infections such as AIDS. Remarkable therapeutic strategies improved the mortality rate in HIV patients. However, the neurocognitive disorders associated with HIV is not helmed properly due to the tight blood-brain barrier that restricts majority of ARVs to enter the brain parenchyma through the cerebral capillary endothelium. Conventional formulations are not adequate to reach these needs in the ARV therapy. Moreover, careful monitoring of pharmacokinetic parameters of the ARV drugs is important to achieve utmost therapeutic efficiency. However, the majority of the drugs are confronting this issue due to their poor aqueous solubility and inappropriate tissue permeability. Diversified nanotechnological and varied accustomed approaches were impended using novel polymers (both natural and synthetic) to ameliorate these pharmacokinetic constraints. Ample literature is available about the nanotechnological approaches allude to the development in the field for the enhancement of oral bioavailability, potency with less side effects. Nanotechnological cherishment also helps to control drug resistance and drug abuse. Making sub-micron level drug particles of poor water-soluble ARV drugs revamp the oral bioavailability by amplified surface area, improved interfacial tension at drug and solvent interface. The permeability issues are abolished by tailoring physical structure of the drug particle. Stability in the gastric environment, bypassing the early hepatic metabolism of ARV drugs also can be conquered with nanotechnological contrivances. Among all, nanocarrier, nano vesicular drug delivery system are well-crammed techniques. This review enumerates a detailed picture of bioavailability enhancement techniques for ARV drugs through nanotechnological advents.
      PubDate: 2022-04-20
      DOI: 10.22377/ajp.v16i1.4268
      Issue No: Vol. 16, No. 1 (2022)
       
  • A Cross-sectional Study on the Extended Role of Clinical Pharmacist in
           Assessing the Risk Factors for Developing Diabetic Foot Ulcers among the
           Diabetic Patients

    • Authors: A. Porselvi
      Abstract: A diabetic foot ulcer (DFU) is the prime cause of poor quality of life among diabetic patients. DFU leads to physical disability and an enormous economic burden on diabetic patients. The development and prognosis of DFU are preventable in most patients by modifying the risk factors for DFU. Programs intervened by clinical pharmacists can enhance rational drugs use and improve the early identification and prevention of DFU. This study intended to prove the beneficial outcome in identifying the risk factors and the provision of patient-tailored referral advice regarding DFU among diabetic patients. This cross-sectional study assessed the neuropathy through Michigan Neuropathy Screening Instrument (MNSI), Monofilament and Vibration test using Tuning Fork and Handheld Doppler for assessing the lower limb vascular disease as per NICE guideline among 137 diabetic patients. 64% of patients were found to have symptoms of neuropathy through the neuropathy assessment test whereas 36% did not have the symptoms. Foot sensory using monofilament test was found to be normal in 49.64% of DFU patients, reduced in 43.80%, and absent in 6.57% of DFU patients. The Ankle Brachial Index (ABI) was found to be normal in 48% of patients, mild in 34% of patients, moderate in 12% of patients, and incompressible in 6% of patients. Clinical Pharmacist intervened risk assessment through Hand-held Doppler, MNSI instrument, and Vibration test helped in screening the DFU patients for Neuropathy, and implementation of effective per patient-tailored education was found to be beneficial in the early identification of DFU and referral to specialty hospitals.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4305
      Issue No: Vol. 16, No. 1 (2022)
       
  • Anti-adipogenic Activity of 3-Hydroxyflavone on 3T3-L1 Pre-adipocyte
           Differentiation

    • Authors: Madhavan Sankar
      Abstract: Objective: The study proposed to explore the anti-adipogenic activity of 3-Hydroxyflavone on 3T3-L1 pre-adipocyte differentiation. Method: 3T3-L1 pre-adipocytes were differentiated into adipocytes in the presence of (3, 3 × 102 and 3 × 104 ng/well) 3-Hydroxyflavone for 6 days, the untreated 3T3-L1 pre-adipocytes served as control. After differentiation, the adipocytes were subjected to Oil Red O staining and the m RNA expression of leptin, peroxisome proliferator activated receptor (PPARγ), and the Sterol regulatory element-binding transcription factor 1 (SREBP-1) were studied. Results: A round-shaped adipocytes were appeared in the cultured medium on the 6th day of the study period. The untreated adipocytes showed intense accumulation of the red dye; however, a dose-dependent reversal of red dye accumulation was seen in the adipocytes on 3-Hydroxyflavone exposure. The m RNA expressions of leptin, PPAR γ and SREBP in the untreated adipocytes were significantly up regulated. However, on 3-Hydroxyflavone treatment, the m RNA expressions of leptin, PPAR γ and SREBP in the adipocytes were down regulated in a dose-dependent manner. The high dose (3 × 104 ng per well) of 3-Hydroxyflavone appreciably reduced the oil accumulation and also significantly down regulated the expression of leptin, PPAR γ and SREBP in the adipocytes. Conclusion: The 3-Hydroxyflavone displayed the anti-adipogenic activity in the adipocytes by reducing the oil accumulation and also by down regulating the m RNA expression of leptin, PPAR γ and SREBP, which are need for the adipogensis.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4295
      Issue No: Vol. 16, No. 1 (2022)
       
  • Age-dependence of Poly(Adenosine Diphosphate-Ribos)yl Polymerase 1
           Inhibition in Liver and Thymocyte Nuclei after the Treatment of Rats with
           Cisplatin

    • Authors: Anush Asatryan
      Abstract: Objective: Poly(ADP-ribos)yl polymerase 1 (PARP1) inhibitors enter into clinical trials for mono and combination cancer chemotherapy, improving curative potential of DNA-alkylating agents. It is documented that therapeutic outcomes after the treatment of patients with broad spectrum of drugs are age-dependent and reveal sexual dimorphism. We investigated age- and sex-dependent differences in PARP1 inhibition by benzamide (Bam) and adenosine triphosphate (ATP) in rat liver and thymocyte nuclei after the treatment of rats with cisplatin. Materials and Methods: The drug was injected intraperitoneal. Animals were treated according to the regulations of National Centre of Bioetics (Armenia). Cell nuclei were isolated according to the standard procedure. PARP 1 activity was evaluated by nicotinamide adenine dinucleotide (NAD)+ consumption. Data are expressed as mean ± S.D. Statistical differences in the results between groups were evaluated by the Student’s t-test. A probability (P) value of <0.05 was considered significant. Key results: Basal PARP 1 activity in rat thymocyte and liver nuclei decreases in the period of animal growth from 6 to 10 weeks. The treatment of intact rat with cisplatin differentially affected PARP 1 activity in liver and thymocyte nuclei. It was shown that efficiency of PARP1 inhibition in thymocyte and liver nuclei by Bam and ATP is age-dependent phenomenon which is affected by in vivo treatment of intact rat with cisplatin. It is suggested that the design of personalized combination therapy regimen should consider cisplatin induced age-dependent changes in PARP 1 inhibition by competing/allosteric inhibitors.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4297
      Issue No: Vol. 16, No. 1 (2022)
       
  • The Association between Omeprazole Dosing and Hypomagnesemia in Patients
           with Cardiovascular Disorders

    • Authors: Nermeen Abuelsoud
      Abstract: Background: Patients with acute coronary syndrome should be treated with proton-pump inhibitors (PPIs) to decrease the gastrointestinal complications and hemorrhage associated with antiplatelets use. Hypomagnesemia associated with PPIs is not confirmed yet but if it is confirmed, it may explain the reason of cardiovascular risks associated with PPIs use. Aims: The aims of this study were to determine the association between omeprazole and hypomagnesemia, study the effect of different omeprazole doses in the occurrence of hypomagnesemia, and study the factors that may contribute to this hypomagnesemia. Methods: Over a 1-year period, all patients receiving omeprazole for more than 1 year admitted to the cardiac care unit were enrolled in this study. Patients were divided to three groups according to the omeprazole doses. The association between omeprazole dose and the presence of hypomagnesemia was assessed and compared between the three groups. Results: A total of 105 patients were enrolled in this study. The mean follow-up duration during hospitalization was 5.2 ± 2.9 days. All factors that may affect the incidence of hypomagnesemia were compared between the three groups and there was not any statistically significant difference between the three groups in relation to patient’s age, sex, presence of diabetes mellitus, and concurrent use of digoxin or diuretics. The incidence of hypomagnesemia between the 3 groups was not statistically significant but it was clinically significant. Conclusion: The hypomagnesemia associated with omeprazole may be dose related. This hypomagnesemia may explain the occurrence the cardiovascular events (arrhythmias and sudden death) after omeprazole use, but further studies are needed.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4298
      Issue No: Vol. 16, No. 1 (2022)
       
  • Design and Evaluation of Losartan Potassium Controlled Release
           Microcapsules

    • Authors: Dr. Vidyadhara Suryadevara
      Abstract: Objective: The objective of the present work is to formulate and evaluate Losartan potassium (LP) controlled release microcapsules using gum karaya and polyethylene oxide as polymers, sodium alginate, and calcium chloride as encapsulating material and cross-linking agent. Materials and Methods: LP controlled release microcapsules were prepared by ionic gelation method. The prepared microcapsules were characterized by flow properties such as angle of repose, compressibility index, particle size, and encapsulation efficiency and drug release profiles. Results: All the prepared microcapsules were spherical and exhibited good flow properties. LP is an antihypertensive drug which comes under the class of angiotension antagonist and it was greatly encapsulated with gum karaya and polyethylene oxide (Water soluble resin 303). The Fourier transform infrared spectroscopy and differential scanning calorimetry studies were conducted for pure drug, polymers and optimized formulations, the studies revealed that they were no incompatibilities between drug and polymers used in the present study. Scanning electron microscopy analysis showed that the microcapsules were uniform and spherical in nature with good surface characteristics. Among all the LP controlled release microcapsule formulations. Conclusions: The optimized formulation (L14) prepared with equal proportion of polymers gum karaya and polyethylene oxide was found to extend the release of drug up to 12 h.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4299
      Issue No: Vol. 16, No. 1 (2022)
       
  • Development and Evaluation of Valsartan Fast Disintegrating Films

    • Authors: Dr. T. Balakrishna
      Abstract: Objective: The aim of the present work was to develop and evaluate the fast disintegrating films (FDF) of valsartan which is used for the treatment of hypertension and heart failure. Method: The valsartan fast disintegrating films were prepared by solvent casting method using hydroxylpropyl cellulose, poly vinyl alcohol (PVA), HPMC E5 as film forming agents, Polyethylene glycol 400 as plasticizers and dimethylsulfoxide as penetration enhancer. Results: Valsartan FDF were developed and evaluated for weight uniformity, drug content, film thickness, and folding endurance, the results obtained were within the specified limits. The in vitro diffusion studies were performed using Franz diffusion cell apparatus containing 6.8 pH phosphate buffer as a dissolution media. Conclusion: The FDF prepared with HPMC E5 at 1:3 ratio released the drug up to 98.7% within 5 min which showed the increased solubility, dissolution rate flexibility, and tensile strength of the films when compared to formulation prepared with hydroxypropyl cellulose and PVA. The Fourier-transform infrared studies were conducted for pure drug, polymers and optimized formulation V9 which indicated that were no incompatibilities found between the drug and polymers used in the present studies. Scanning electron microscopy analysis was performed for pure drug, polymers, and optimized formulation V9 which showed that they were no surface fractures and cracks in the films.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4300
      Issue No: Vol. 16, No. 1 (2022)
       
  • Formulation Characterization of Statistically Optimized Naproxen
           Nanocrystals with Quality by Design

    • Authors: Polepalli Sindhuri
      Abstract: Objective: The present objective of the study is to prepare nanoparticles of naproxen and then converting them into a suitable dosage form. Initially, the nanosuspension of naproxen is prepared using anti-solvent precipitation technique. The ideal and best formation obtained with the application of DOE. The best nanosuspension is freeze dried to get nanoparticles which is used for further study. In addition, the various process parameters which have a potential influence on the formulation are also studied. Methods: Solventanti- solvent precipitation method was employed as the preparation technique. A full factorial design (24) is used to design the experiment. Based on the previous studies and literature review, the parameters were selected. The experimental design is designed in such a way to assess various parameters such as critical process parameters, material attributes, and process parameters. Naproxen nanosuspensions were lyophilized with mannitol. The experimental data obtained were subjected to statistical analysis using various methods such as regression and ANOVA. Other evaluation procedures were followed to determine the various characteristics of the formulation and dissolution and pharmacokinetic studies are also performed. Results: The DOE and factorial design showed the point prediction as stirring time of 22.5 min and rate of injection as 0.4 ml/min, solvent-antisolvent ratio of 1:15, and stabilizer drug concentration of 1:7.5. The nanoparticles were found to be intact in SEM/TEM analysis and there were no drug interactions between the formulation ingredients. The zeta potential was found to be 50.2 mv. The pharmacokinetic analysis of nanoparticles showed AUC of 836 ng/ml which is twice obtained with that of pure drug. Other parameters like bioavailability of the formed nanoparticles have improved significantly when compared with that of pure naproxen. Conclusion: Naproxen nanosuspensions have been successfully prepared and the various process parameters which have an effect on the characteristics are studied. The predicted formulation has been prepared and evaluated for various parameters and found pharmacokinetically better when compared to pure drug.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4301
      Issue No: Vol. 16, No. 1 (2022)
       
  • Chronotherapeutic Press-Coated Tablets of Tramadol Hydrochloride: In Vivo
           Evaluation

    • Authors: Ramya Krishna Talakoti
      Abstract: Objective: The purpose of this study is to conduct in vivo pharmacokinetic study of Tramadol Hydrochloride (TH) press-coated tablets (PCTs) in rabbit plasma using reversed-phase high-performance liquid chromatography (RP-HPLC) technique. Materials and Methods: A Phenomenex bond clone reverse phase C18 (4.6 × 150 mm, 5μm) column and mobile phase acetonitrile – 0.01 M phosphate buffer (30:70% v/v) containing 0.1 % triethylamine with 1 ml/min flow rate were used for development and validation of RP-HPLC method, further used to calculate various pharmacokinetic parameters of TH core tablets and PCT in rabbits which received TH core and PCTs. Results and Discussion: The developed method showed a linearity in range of 10–800 ng/ml (r2 = 0.9997), good precision and accuracy with acceptable relative standard deviation values, repeatability, and reproducibility. The drug TH extracted with recovery in range of 96.20–98.29%. The pharmacokinetic study of PCT showed 5 h lag time with drug release. The Cmax and Tmax of core tablet and PCTs were 409.86 ± 40.46 ng/ml at 0.75 h and 289.46 ± 32.58 ng/ml at 10 h, respectively. Area under curve(0-t) of core and PCTs was 1531.26 ± 499.09 ngh/ml and 2293.48 ± 521.8 ngh/ml, respectively. Conclusion: Based on results, PCTs provided better chronotherapeutic release characteristics with drug release after a specified lag time using polymer blend of HPMC E50 and HPMC E100 as release modifiers for therapy of Rheumatoid arthritis.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4302
      Issue No: Vol. 16, No. 1 (2022)
       
  • Design, Optimization, and Characterization of Herbal Face Pack

    • Authors: Saloni Jain
      Abstract: The goal of this project is to develop and test a polyherbal face pack made of herbal substances for cosmetic purposes. Amla (Emblica officinalis), masoordaal (Lens culinaris), and rose petals were obtained from a local market and dried, powdered, then geometrically blended and analyzed for organoleptic and physico-chemical, general powder characteristics, and chemical assessment. The mixed dry powder has an acceptable flow property, making it ideal for use as a face pack. Four distinct compositions incorporating components such as Amla (E. officinalis), masoordaal (L. culinaris), and rose petals powder were developed with variable quantities and called F1 to F4. Different metrics such as organoleptic qualities, physicochemical parameters, and stability, as well as an irritancy test and microbiological load, were used to assess all of the created compositions. The powder’s particle size ranged from 23.3 to 26.9 m. F2 outperformed all other formulations in terms of physical metrics, skin irritation, and consistency even after stable storage conditions.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4304
      Issue No: Vol. 16, No. 1 (2022)
       
  • Recent Approaches of Gastroretentive Drug Delivery System – A Review

    • Authors: Dr. S. Jeganath
      Abstract: The most effective and approved drug delivery method was the oral route. Due to the enormous therapeutic advantages of orally controlled release dosage forms, enhanced medicinal benefits are favored as the important perspective in the pharmaceutical field. Gastroretentive drug delivery system (GRDDS) is an innovative drug delivery method that has an advantage due to its ability to keep extended stomach retention and thus improve drug stomach residence time and also enhance drug bioavailability. Many technological methods, such as swelling and expansion, mucoadhesive, high density, ion exchange, raft forming, magnetic, and floating drug delivery systems, are used to prolong gastric residence time. The objective of this analysis on GRDDSs was to assemble of different gastroretentive approaches that are previously leading methods in the field orally administered controlled release drug delivery.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4273
      Issue No: Vol. 16, No. 1 (2022)
       
  • Role of Topical Flavonoids as Antioxidants to Preserve Healthy Skin
           – A Review

    • Authors: Mrs. Saloni Jain
      Abstract: As a result of the negative effect of some of the horny extract’s associated proteins, the skin is continuously exposed to numerous environmental factors, particularly pollution as well as ultraviolet radiation (UV). As a result, the horny isolate can be adversely affected by the toxic influence of many of its associated proteins. The immediate absorption of UV light through the use of epithelial chromophores, the creation of excited states as well as the subsequent chemical changes, or even photosensitization processes, wherein UV light is absorbed by excited photosensitizer and their responses encourage the production of reactive oxygen species, are all processes that are involved in the environmental pollutants advanced by UV light. Polluting chemicals’ actions are not completely understood, but evidence suggests that one of the key processes involved is oxidative stress caused by lipid peroxidation, which has the potential to cause harm to sebum content, stratum corneum integrity, and skin ageing. Numerous studies have indicated the effectiveness of natural antioxidants, with a focus on natural substances, in promoting the preservation of the skin’s physiological equilibrium.
      PubDate: 2022-03-15
      DOI: 10.22377/ajp.v16i1.4274
      Issue No: Vol. 16, No. 1 (2022)
       
 
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