A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  

        1 2 3 | Last   [Sort by number of followers]   [Restore default list]

  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 31)
AAPS Open     Open Access   (Followers: 5)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 5)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 3)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 101)
Advanced Herbal Medicine     Open Access   (Followers: 9)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 5)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 3)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 11)
Advances in Pharmacology     Full-text available via subscription   (Followers: 21)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 9)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 4)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 4)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 11)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 3)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 9)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 21)
American Journal of Drug Discovery and Development     Open Access   (Followers: 3)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 60)
American Journal of Pharmacological Sciences     Open Access   (Followers: 2)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 24)
American Journal of Therapeutics     Hybrid Journal   (Followers: 13)
Analytical Methods     Hybrid Journal   (Followers: 8)
Annales Pharmaceutiques Francaises     Full-text available via subscription  
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 56)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 38)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 6)
Antibiotics     Open Access   (Followers: 12)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 8)
Applied Clinical Trials     Full-text available via subscription   (Followers: 7)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 2)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Archives of Razi Institute     Open Access   (Followers: 1)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Pharmaceutics     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Pharmaceutical Journal     Full-text available via subscription  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 15)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Bioanalysis     Full-text available via subscription   (Followers: 11)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
BioDrugs     Full-text available via subscription   (Followers: 8)
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 3)
Biomarkers in Drug Development     Partially Free   (Followers: 2)
Biomaterials     Hybrid Journal   (Followers: 56)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 2)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 9)
Biopharm International     Full-text available via subscription   (Followers: 20)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 11)
BMC Pharmacology     Open Access   (Followers: 3)
BMC Pharmacology & Toxicology     Open Access   (Followers: 9)
Brazilian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 31)
British Journal of Pharmacology     Hybrid Journal   (Followers: 17)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 2)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 14)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical and Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 1)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 22)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Ciencia e Investigación     Open Access  
Ciência Equatorial     Open Access  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 7)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access  
Clinical Drug Investigation     Full-text available via subscription   (Followers: 7)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 11)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 27)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 45)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 4)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 6)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 9)
Clinical Therapeutics     Hybrid Journal   (Followers: 34)
Clinical Toxicology     Hybrid Journal   (Followers: 18)
Clinical Trials     Hybrid Journal   (Followers: 19)
CNS Drug Reviews     Open Access   (Followers: 4)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 11)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Therapeutic Drug Carrier Systems     Full-text available via subscription   (Followers: 5)
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 25)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 4)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 6)
Current Drug Metabolism     Hybrid Journal   (Followers: 5)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 4)
Current Drug Therapy     Hybrid Journal   (Followers: 3)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 13)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 9)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 10)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 12)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 2)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 1)
Current Therapeutic Research     Open Access   (Followers: 6)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 7)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 4)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 5)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 13)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 8)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 3)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 30)
Drug Development Research     Hybrid Journal   (Followers: 11)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 12)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 11)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 6)
Drug Metabolism Letters     Hybrid Journal   (Followers: 3)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 8)
Drug Research     Hybrid Journal   (Followers: 3)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 88)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 10)
Drugs     Full-text available via subscription   (Followers: 153)
Drugs & Aging     Full-text available via subscription   (Followers: 10)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs and Therapy Studies     Open Access  
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 7)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Egyptian Pharmaceutical Journal     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 1)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 9)
Epilepsy Research     Hybrid Journal   (Followers: 8)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 14)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 8)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 90)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 35)
European Journal of Pharmacology     Hybrid Journal   (Followers: 8)
European Medical, Health and Pharmaceutical Journal     Open Access   (Followers: 2)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 9)
European Review for Medical and Pharmacological Sciences     Full-text available via subscription   (Followers: 1)

        1 2 3 | Last   [Sort by number of followers]   [Restore default list]

Similar Journals
Journal Cover
Asian Journal of Pharmaceutics
Journal Prestige (SJR): 0.144
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0973-8398 - ISSN (Online) 1998-409X
Published by Mandsaur Institute of Pharmacy Homepage  [1 journal]
  • Pharmacological Properties of Fructooligosaccharides Modulates the
           Lipopolysaccharide-Induced Gastrointestinal Tract Inflammation in Mice

    • Authors: Shreya
      Abstract: Objective: The gut is a neuroendocrine-immune organ, vulnerable to stress, and toxic agents, including
      lipopolysaccharide (LPS) leading to gut dysbiosis and inflammation. The aim of present study was to evaluate the
      pharmacological properties of prebiotic fructooligosaccharides (FOS) against the LPS-induced gut inflammation
      in mice. Materials and Methods: The Swiss albino mice (female, 8 weeks) were divided into following four
      groups (n = 6/group): Group-I/Control: received saline (0.9% NaCl), (II) Group-II/LPS (1 mg/kg for 5 days,
      intraperitoneal), Group-III/LPS+FOS (LPS 1 mg/kg for 5 days followed by FOS 2 g/kg for 28 days), and
      Group-IV/FOS (FOS 2 g/kg for 28 days, through oral gavaging). Results: The LPS exposure significantly
      decreased the body and gut weight compared to control which, after the FOS treatment, increased to control level.
      In LPS-exposed mice, the decreased of gut associated superoxide dismutase and catalase activity was enhanced
      and normalized by FOS. Similarly, LPS-induced the pro-inflammatory cytokines IL-6 and TNF-α level were
      also decreased to control level after FOS treatment. Moreover, LPS exposure caused various histopathological
      alterations in gut, such as lesions of epithelial layer, edema of villi, and disruption of goblet cells, in which
      FOS modulated. Conclusion: The pharmacological prebiotic FOS shows the anti-oxidative, anti-inflammatory
      properties which modulated the LPS-induced gut toxicity by decreasing inflammation and oxidative stress and
      improving histological architecture.
      PubDate: 2023-07-11
      DOI: 10.22377/ajp.v17i2.4855
      Issue No: Vol. 17, No. 2 (2023)
  • Air Pollutants Causing Diseases, Their Detection and Measurement Using
           Different Hyphenated Analytical Techniques: A Quick Insight

    • Authors: Deepika Bairagee
      Abstract: Air pollution, a significant environmental risk factor, is regarded to be the root cause of certain ailments, including
      asthma, lung cancer, and ventricular hypertrophy. According to the World Health Organization, some of the major
      air pollutants include lead, carbon monoxide (CO), sulfur oxides, CO at ground level, and particle pollution. Both
      short-term and long-term exposure to polluted air can have a number of toxicological consequences on the human
      body, including respiratory and cardiovascular problems, neuropsychiatric issues, eye irritation, skin conditions,
      and chronic illnesses like cancer. Different advanced analytical techniques such as gas chromatography-mass
      spectrometry, infrared radiation absorption, and laser, where laser radiation is sent through a sample of atmosphere
      to be investigated either as transmission, or the scattering of the light all the way through a different physical
      process, produce a variety of different techniques for monitoring air quality. This article has detailed the primary
      air pollutants, their sources of emission, their effects on human health, and the methods used to detect them to
      discover solutions to minimize them.
      PubDate: 2023-07-08
      DOI: 10.22377/ajp.v17i2.4836
      Issue No: Vol. 17, No. 2 (2023)
  • A Modern Method for Analyzing Related Substances of Cabotegravir and
           Rilpivirine Using RP-HPLC, along with the Characterization of their
           Degradation Products Via LCMS

    • Authors: Krishnaveni Gudela
      Abstract: Introduction: The estimation, separation, and validation of Cabotegravir and Rilpivirine along with their
      impurities were performed using the RP-HPLC technique. Materials and Methods: Cabotegravir, Rilpivirine,
      and their respective impurities were separated on an Inertsil ODS column (150 × 4.6 mm, 3.5 μ) using a
      mobile phase consisting of 5 mM Ammonium Formate and acetonitrile at a flow rate of 1 mL/min at room
      temperature. The PDA detector from a Waters HPLC e-2695 quaternary pump was used with a wavelength of
      231 nm. The linearity was investigated for 17 min with injection concentrations of 75–450 μg/mL of Rilpivirine,
      50–300 μg/mL of Cabotegravir, and 1.25–7.5 μg/mL of each impurity of Cabotegravir and Rilpivirine. The validity
      of the proposed method was verified using the International Conference on Harmonization (ICH) guidelines.
      Results and Discussion: The results of method validation including specificity, linearity, accuracy, ruggedness,
      and robustness were within the permissible range. Conclusion: The HPLC-MS technique successfully validated
      the chemical structures of the degradation products of Cabotegravir and Rilpivirine, and stress studies were carried
      out in compliance with ICH Q2 (R1) guidelines
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4872
      Issue No: Vol. 17, No. 2 (2023)
  • Nanotechnology Driven Approach with Collagen and Mupirocin-loaded Silver
           Nanoparticles in Chitosan Hydrogel for Burn Wound Infection

    • Authors: Veintramuthu Sankar
      Abstract: Aim: The present investigation was to formulate Mupirocin- and collagen-loaded silver nanoparticles in chitosan
      hydrogel which has synergistic wound healing and anti-bacterial activity. Materials and Methods: Extraction
      and characterization of acid-soluble collagen from tilapia fish scales were performed. Mupirocin and collagen
      silver nanoparticles (Mup-AgNP-Col) were synthesized by chemical reduction method using sodium borohydride
      as reducing agent. Using design expert software, Mup-AgNP-Col preparations were optimized. Chitosan hydrogel
      was prepared and the optimized Mup-AgNP-Col formulation was loaded in the gel and evaluation parameters
      were assessed. Results: The optimized Mup-AgNP-Col formulation with silver nitrate concentrations of 4.3 mM,
      sodium borohydride concentration of 2 mM, and collagen concentration of 0.1 mg showed spherical structure
      with particle size as 121 ± 1.18 nm. The entrapment efficiency was found to be 91.3 ± 2.8 % and at the end of 6 h
      in vitro, release studies showed 91 ± 2.89% drug release in phosphate buffer, pH 7.4. Non-toxic and wound-healing
      activity was confirmed by L929 fibroblast cell line study. The formulated gel was evaluated for its spreadability
      and extrudability. Conclusion: Mup-AgNP-Col in chitosan hydrogel enhances burn wound healing.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4873
      Issue No: Vol. 17, No. 2 (2023)
  • Design and Development of Self-Emulsifying Drug Delivery Systems of

    • Authors: D. Madhuri
      Abstract: Tolvaptan, a selective vasopressin receptor antagonist, is a poorly soluble drug. It is used to treat hyponatremia.
      To solve the solubility problem and enhance bioavailability, a novel approach of self-emulsifying drug delivery
      systems was used. These are isotropic mixtures of oil, surfactants, and cosurfactants, when they contact with
      the GI fluid spontaneously produce fine oil-in-water emulsion and are subsequently absorbed into lymphatic
      pathways, bypassing the first-pass hepatic effect. Cinnamon oil and orange oil were used as oils, Tween 80, Tween
      60, and Tween 20 were used as surfactants and propylene glycol, poly ethylene glycol 400, and ethanol are used as
      cosurfactants for the formulation and there by evaluated. The droplet sizes are in ranges of 37.8–176 μm and PDI
      value is 0.271. The zeta potential value is −1.6 mV and the amount of drug release is that 81.50% was observed
      in F5 formulation. It conclude that the self-micro emulsifying drug delivery system is suitable for Tolvaptan drug
      to improve the drug release and there by bioavailabilty.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4874
      Issue No: Vol. 17, No. 2 (2023)
  • Development and Optimization of Intravaginal Mucoadhesive Microspheres of
           Econazole Nitrate

    • Authors: Suresh Kumar Paswan
      Abstract: The most common disease in the female vaginal tract is vaginal candidiasis caused by the microbe
      Candida Albicans. The conventional formulation for the treatment of this disease shows a lack of retention of
      the dosage form in the vaginal cavity due to the natural draining of vaginal fluid that leads to leakiness and
      Messiness, which tends to escape during normal routine work. The mucoadhesive delivery of antifungal drugs in
      the treatment of vaginal candidiasis is an alternative to delivering drugs for a longer time. In this research work,
      econazole nitrate-loaded mucoadhesive microspheres were developed by spray drying method and compressed
      into a vaginal tablet which disintegrates rapidly into microspheres in the vaginal cavity and adheres to vaginal
      mucosa for a longer time. Methods and Materials: Econazole nitrate-loaded microspheres were prepared and
      characterized in terms of particle size, drug loading, ex vivo mucoadhesion study, and in vitro drug release study.
      A three-factor and three-level Box–Behnken design was employed to optimize the formulation, and the effect
      of independent variables HPMC K 100M, Eudragit RSPO, and Eudragit RLPO on formulation was analyzed.
      Results and Discussion: The particle size of the optimized formulation was found to be 25μ. The drug loading
      and in vitro release study at 6 h were 23% and 93%, respectively. The data from the in vitro drug release study
      show that the drug is released in a sustained manner due to release retarding polymer Eudragit RSPO and Eudragit
      RLPO and the % mucoadhesion of the optimized microsphere was found to be 70 % after 8 h in contact with vaginal
      fluid due to mucoadhesive property of HPMC K100M, tablet disintegrate rapidly into microsphere which adheres
      to the vaginal wall and consistently release drug up to 6 h. Conclusion: The mucoadhesive microsphere prepared
      by the spray dryer provides a mucoadhesion phenomenon that allows the adherence of the microsphere to the
      vaginal mucosa so that drug retention time is increased. The prepared vaginal tablet overcomes the drawback of
      conventional formulations and disintegrates rapidly into a mucoadhesive microsphere and adheres to the vaginal
      lumen so that the retention time of the drug is increased.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4847
      Issue No: Vol. 17, No. 2 (2023)
  • Enhancement of Solubility and Dissolution Rate of Lumefantrine by
           Pharmaceutical Cocrystals

    • Authors: V. B. Ghawate
      Abstract: The solid-state properties of drug compounds, such as solubility and dissolution, can be changed by
      cocrystallizing the drug with coformers. The purpose of the current effort was to identify potential coformers and
      then develop, formulate, and assess the lumefantrine cocrystal. Methods: Lumefantrine cocrystals were created
      using the solvent evaporation process. The crystalline phase’s melting temperature and solubility were established.
      DSC, IR, and XRPD were used to characterize the putative cocrystal. Evaluations were also conducted on
      solubility and dissolution rate, two additional medicinal qualities. Results and Discussion: Lumefantrine-adipic
      acid cocrystals showed a range in solubility and melting points. Adipic acid and the cocrystals were combined
      in a 1:1 ratio. The infrared research clearly showed that the lumefantrine distinctive bands were changing.
      A notable variation in the 2θ of the strong peaks and the crystallinity of cocrystals were indicated by the X-ray
      powder diffraction pattern. Cocrystal’s differential scanning calorimetry spectra revealed changed melting point
      endotherms. Due to cocrystallization, the cocrystals showed a higher rate of dissolution, as seen by an increase
      in the extent of dissolution. Conclusion: The lumefantrine cocrystal with modified properties was prepared with
      adipic acid having greater solubility and dissolution rate of the drug.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4848
      Issue No: Vol. 17, No. 2 (2023)
  • Oral Formulation of Posaconazole in Nanosuspension: Development and
           Optimization by Design of Experiments Approach

    • Authors: T. V. Gautham
      Abstract: Introduction: FR and D scientists continuously try to increase the in vivo performance of low soluble and poor
      bioavailable drugs using various formulation techniques. Nanosuspensions are relatively simple to develop and
      fall within the novel drug delivery approaches. Materials and Methods: The polymers such as soya lecithin,
      Tween 80, poloxamer, and polyethylene glycol were used for the preparation. Central composite design was used
      to optimize the posaconazole nanosuspension and formulation was characterized for various parameters, that is,
      particle size, morphology and physicochemical parameters were evaluated for in vitro and in vivo performance.
      Results: Optimized nanosuspension contained an average particle size of 219 ± 0.25 nm and zeta potential was
      −19.3 ± 6.73 mV. The optimized nanosuspension displayed a significant increase in dissolution profile, by more
      than 4 folds on average as compared to the drug within 60 min. The results of the pharmacokinetic (PK) study
      showed the optimized nanosuspension releases the drug with maximum bioavailability as compared to marketed
      formulation. The formulation found stable up to 6 months. Conclusion: The development of nanosuspension
      resulted in superior performance in PK effects over the marketed formulation.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4849
      Issue No: Vol. 17, No. 2 (2023)
  • Formulation Designing and Optimization of Loteprednol-loaded spanlastic
           Nanocarriers for Treatment of Ocular Inflammation

    • Authors: Prakash K. Soni
      Abstract: Objective: The objective of this scientific work was focused on formulation, optimization and evaluation of
      loteprednol-loaded spanlastic nanocarriers for effective treatment of ocular inflammation with enhanced
      transcorneal drug permeation, prolonged corneal residence time, and sustained drug release profile.
      Materials and Methods: The spanlastic nanocarriers of loteprednol was prepared by ethanol injection method
      using Span 60 and Tween 80 as vesicular components. A 23 factorial design was employed in the optimization studies
      selecting independent variables such as Span 60, Tween 80, and drug content, whereas, the response variables such
      as particle size, polydispersity index, zeta potential, entrapment efficiency, and cumulative % drug release. The
      optimized formulation was evaluated for various in vitro and ex vivo parameters. Results and Discussion: The
      optimized formulation of spanlastic nanocarriers of loteprednol was found to have 207.4 nm particle size, 0.41
      polydispersity index, −0.62 mV zeta potential, and 58.23% entrapment efficiency. The cumulative % drug release
      was 98.45% during 8-h period exhibiting sustained release and Korsmeyer-Peppas model release kinetics. The
      ex vivo drug permeation study across goat eye cornea exhibited apparent permeability (Papp) of 11.95 cm/min-1
      and steady-state flux (Jss)of 19.45 mg/cm2 min-1which was >5 times higher than marketed product. The developed
      formulation maintained its physical characteristics and possessed all desired product quality attributes in the
      ideal range. Conclusion: The developed loteprednol loaded spanlastic nanocarriers demonstrated all the quality
      parameters very close to the software predicted values and also exhibited enhanced transcorneal drug permeation
      which would lead to higher ocular drug bioavailability and need of less frequent drug administration in effective
      management of ocular inflammation.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4851
      Issue No: Vol. 17, No. 2 (2023)
  • Formulation and Evaluation of Hair Tonic for Alopecia from Cow Urine

    • Authors: G. Wagh Jyoti
      Abstract: Alopecia since the dawn of mankind, this issue has affected all ethnicities and both sexes to varying
      degrees. In allopathy, the treatment of all hair problems is expensive and cannot be afforded by poor people.
      Herbal hair preparations are free from various side effects that of chemically synthesized, for example, Minoxidil
      has side effects that are local irritation, itching and burning sensations are frequent. Instead of using various
      formulations for different hair problems, there is a necessity to formulate one single preparation which overcomes
      maximum hair problems. Since ancient times, cow pee has been utilized to treat a variety of human illnesses. It
      is a crucial and integral component of Panchgavya Chikitsa. Materials and Methods: Crude drug samples were
      collected and authentified. 10–15 g methi, kept it in aloe vera for sprouting. Sprouted methi was collected in in
      500ml cow urine and collected distillate. After boiling kept it for overnight standing, filter the formulation using
      a muslin cloth, and packed in a suitable container. Results and Discussion: The protocol study was approved
      by the Institute Animal Ethical Committee for animal experimentation. The study was performed gave good hair
      growth activity. To improve people’s health and way of life, it is important to raise public awareness of the value
      and variety of uses of cow urine. In this study, cow urine is used along with methi and aloe vera to formulate a hair
      tonic to cure the alopecia. Conclusion: Formulated hair tonic is having excellent hair growth-promoting activity,
      with good antifungal activity. It will act as a potent herbal alternative without any side effects.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4852
      Issue No: Vol. 17, No. 2 (2023)
  • Nanoparticulate Drug Delivery: Ezetimibe and Enteric-coated Atorvastatin
           in Hard Gelatin Capsules

    • Authors: S. Subramanian
      Abstract: Aims: Atorvastatin (ATV) and ezetimibe (EZT), being BCS class II drugs, are used to treat dyslipidemia. In this
      study, the formulation of hard gelatin capsule containing a fixed dose combination of EZT and enteric-coated ATV
      enhances the rate of dissolution through solubility using nanoprecipitation method. Materials and Methods: ATV
      nanoparticles (NPs) and EZT NPs were prepared using polyvinyl pyrrolidine k-30 as an amorphous carrier in
      various drug to polymer ratios. The formulated NPs of both drugs were characterized for their particle size, zeta
      potential, and polydispersity index, and for optimized formulation entrapment efficiency and scanning electron
      microscopy (SEM) which were determined. AT VNPs were coated using ethyl cellulose and were characterized.
      Flow characteristics of enteric-coated ATV and EZT NPs were assessed and filled into empty hard gelatin
      capsules. The hard gelatin capsule containing powders of EZT and enteric-coated ATV NPs was also evaluated
      for weight variation, disintegration time, in vitro drug release, and drug content. Results and Discussion: The
      particle size for the formulation of ATV NP and EZT NP was found to be 470.5 nm and 469.2 nm, respectively.
      The morphology of the best formulation for both NPs, determined using SEM, indicates that they are spherical in
      shape. The in vitro release studies of enteric-coated ATV NPs show 5% release in an acidic pH for 2 h followed
      by 92.89% release in a basic pH at the end of 3 h before loading into hard gelatin capsules to prove that there was
      no release of ATV NPs in acidic medium. Hard gelatin capsules containing enteric-coated ATV NPs and EZT NPs
      showed drug release of 98% and 99% within 45 min. Conclusion: The hard gelatin capsule of enteric-coated ATV
      NPs and EZT NPs showed better drug release when compared to the marketed formulation.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4853
      Issue No: Vol. 17, No. 2 (2023)
  • Development of Tretinoin-Loaded Nanostructured Lipid Carrier and
           Hyaluronic Acid Topical Gel

    • Authors: S. Subramanian
      Abstract: The current study was focussed on the fabrication of nanostructered lipid carrier (NLC) of tretinoin
      (TRE) followed by its incorporation into hyaluronic acid (HA)-loaded carbapol 940 gel aiming to improve acne
      treatment. Materials and Methods: The TRE-NLC was fabricated using melt-emulsification and ultrasonication
      method. The fabricated NLC was studied for its particle size, zeta potential, polydispersity index, morphology,
      and entrapment efficiency of TRE. The gel containing HA and TRE-NLC were evaluated for pH, spreadability,
      extrudability, bloom strength, and viscosity. The in vitro release studies and in vitro occlusivity test for the
      formulated gel and marketed gel were carried out. Results and Discussion: The formulated gel showed better
      release of 86.32% when compared to marketed gel with 38.52% release in 8 h. Occlusion factor can be related
      to skin hydration based upon the ability to prevent water loss from the surface of the skin which was found to
      be 42.29% for the formulated gel and 4.76% for the marketed gel. Conclusion: The combination of TRE-loaded
      NLCs and HA gel may provide a more effective treatment for acne by diminishing the dryness than either TRE
      or HA gel alone.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4854
      Issue No: Vol. 17, No. 2 (2023)
  • Knowledge, Attitudes, and Perceptions Regarding the Future of Artificial
           Intelligence among Health-care Professionals

    • Authors: Nehad J. Ahmed
      Abstract: Artificial intelligence (AI) systems have been extensively employed in a variety of fields including
      medicine. The present study aimed to describe Saudi Arabian health-care professionals’ knowledge, attitudes, and
      perceptions of the future of AI. Materials and Methods: The present study was a cross-sectional study that was
      carried out in November 2022 and included an online survey to describe Saudi Arabian health-care professionals’
      knowledge, attitudes, and perceptions of the future of AI. Results: The survey was filled out by 174 health-care
      workers. About 87.9% of health-care professionals said they are familiar with AI and its uses. About 89.7% said
      that they would like to use a software/program that can be helpful in disease diagnosis and treatment. More than
      97% of health-care workers agreed that AI has a future in the medical field and 93.1% of them agreed that AI will
      help them in making decisions. Conclusion: Health-care professionals are concerned about the possible effects
      of its widespread application in clinical practice. Attending lectures, conferences, and workshops is essential for
      enhancing health-care professionals’ knowledge and attitude regarding AI and reducing their conflict.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4856
      Issue No: Vol. 17, No. 2 (2023)
  • UV Spectrophotometric Analysis of Miconazole Nitrate and Eugenol in
           Topical Formulation

    • Authors: Aarti S. Zanwar
      Abstract: Fungal infection remains a continuous and growing threat to human health. Combination therapy
      may be an optional approach for the treatment of invasive fungal infections, and the potential antifungal mechanisms
      provide new insights into novel antifungal drug development. Several papers have proven that blend of miconazole
      nitrate and eugenol has synergistic antifungal effect. Therefore, a formulation used eugenol to increase the skin
      penetration and increase the availability of miconazole nitrate in topical gels. As a result, a method for simultaneous
      measurement of the aforementioned medicines in the formulation of emulgel has been devised and validated using
      UV spectrophotometric analysis. Materials and Methods: In the simultaneous equation method, absorbance was
      measured at 272 and 280 nm for the estimation of both drugs. Miconazole nitrate and eugenol were estimated at
      281 and 271 nm in the first derivative (zero crossing) method, respectively. The ratio derivative method utilized
      peak amplitudes at 283 and 274 nm for miconazole nitrate and 286 and 292 nm for eugenol. The developed
      methods were validated according to the ICH guidelines, including parameters such as specificity, linearity,
      range, precision, accuracy, limit of detection, and limit of quantification. Results and Discussion: All three assay
      methods showed a direct relationship between response and concentration in the concentration range of 100–
      600 μg/mL for miconazole nitrate and 53–318 μg/mL for eugenol. The level of dispersion was within 2% of the
      RSD. Recovery studies for both drugs ranged from 97 to 102%, recommending that the methods are effective.
      Conclusion: All of the proposed techniques were found to be quick, accurate, and inexpensive. As a result,
      they can now be helpful for routine quality control analysis when calculating miconazole nitrate and eugenol in
      emulgel formulation or formulations containing the aforementioned medications.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4857
      Issue No: Vol. 17, No. 2 (2023)
  • Prevalence and Pattern of the Elongated Styloid Process among a Saudi

    • Authors: Salah Eldeen Dafalla
      Abstract: Introduction: The objectives of this study were to assess the elongation of the styloid process (SP) on digital panoramic radiographs (DPRs) and to evaluate the prevalence of the elongation according to age, sex, and type. Materials and Methods: DPRs of 198 geriatric edentulous patients were analyzed. The radiographic length of the SP was measured on both sides using the measurement toolbars on the accompanying analysis software. The student’s t-test, Chi-square test, and analysis of variance test were used for statistical analysis. Results and Discussion: The elongated SP was seen in 87 of the 198 patients. It was observed that as age increased, elongation of the SP increased with a male predominance. Type I elongation was more common than other types of elongation. Bilateral elongation was more commonly found than unilateral elongation, and both types of elongation were frequently seen in males compared to females. Conclusions: The prevalence of the elongated SP in the present study was higher than the other reports from edentulous patients.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4858
      Issue No: Vol. 17, No. 2 (2023)
  • An In-Silico and In-Vitro Study of Imatinib and Naringin Combination for
           Inhibiting P-Glycoprotein and Delaying Drug Resistance in Chronic Myeloid

    • Authors: Kiranmai Gudimetla
      Abstract: Introduction: The present study describes the potential use of naringin (NAR), a flavanone glycoside, in combination
      with imatinib (IMT), a signal transduction inhibitor used in chronic myeloid leukemia (CML). The study aimed to
      investigate whether NAR could help overcome the multidrug resistance of IMT by inhibiting the overexpression
      of the P-glycoprotein gene. Materials and Methods: Molecular docking approach is used to investigate the
      binding affinity of IMT and NAR to human P-glycoprotein. The results showed that IMT had stronger interactions
      with P-glycoprotein than NAR, indicating better stability with a binding energy of −7.3 kcal/mol compared
      to −5.6 kcol/mol for NAR. However, NAR demonstrated an excellent affinity toward human P-glycoprotein.
      Results: To investigate the effect of NAR and IMT combination on P-glycoprotein expression, flow cytometry
      technique on K562 cell lines is used. The results displayed that IMT alone at a concentration of 1 μM had a P-gp
      expression of 73.6%. Nevertheless, P-gp expression was substantially decreased to 9.7% when coupled with NAR
      at higher doses (5–30 µM). Moreover, pure NAR alone also showed suppression of P-gp expression. In summary,
      the study suggests that the combinatorial approach of IMT with NAR could enhance anticancer activity and delay
      drug resistance by reducing P-gp expression in K562 cell lines. Conclusion: These results support the potential
      use of NAR as an adjuvant therapy to IMT in the management of CML. However, further studies are needed to
      confirm the efficacy and safety of this approach in clinical settings.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4859
      Issue No: Vol. 17, No. 2 (2023)
  • In silico-guided Molecular Docking Analysis of Doxorubicin with
           Low-density Lipoprotein

    • Authors: Sanjay K. Jain
      Abstract: Introduction: Brain tumor (BT), the most aggressive and difficult-to-treat malignancy, is the major cause of
      death in cancer patients. BT poses serious health concerns mainly because of their fast development and poor
      prognosis. BT includes a group of heterogeneous diseases, with unique biology that corresponds to the brain
      and its microenvironment. The brain contains many cell types distinct from those found elsewhere in the body,
      making it difficult to extrapolate the findings from brain cancers compared to other forms of cancer. Moreover, the
      anatomy of the brain presents challenges for treating both BTs and brain metastases. The brain is the hub of many
      proteins in which some of the proteins act as receptors for natural and synthetic ligands. Doxorubicin (DOX) is one
      of the most commonly used anticancerous drugs with high efficacy. Materials and Methods: In silico analysis
      provides key insights in designing effective drug delivery to the brain. Here, the molecular modeling package
      Schrödinger software was used to establish the specific interaction between DOX and low-density lipoprotein
      (LDL). Results and Discussion: DOX has good binding interactions (docking scores −8.526, −6.565, −6.667,
      and −7.040, respectively) with LDL (PDB ID: IN7D and 3M0C). The docking study of DOX found potent activity
      against BT with docking scores of −8.526, −6.565, −6.667, and −7.040. Conclusion: The present study may help
      medicinal scientists to formulate potent formulation against LDL receptor for BT targeting.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4860
      Issue No: Vol. 17, No. 2 (2023)
  • Liquid Oral Floating In Situ GELS: A Review

    • Authors: Dr. J. P. Yanadaiah
      Abstract: The oral route technique is the most common technique for the oral administration of drugs into the body. It
      overcomes that the problems like drug targeting to organs can cause problems for administration through the oral
      route. The ideal solution to solve the issues of the quick release and brief gastrointestinal residence of liquids is to
      design a unique strategy, which is an in situ drug delivery system. It also prolongs the gastric residence time and
      controls the rate of drug release which can improve oral bioavailability and reduce the frequency of dosing. It is a
      particular variety of hydrogel that can hold a significant quantity of water and biological fluids without swelling.
      In in situ gelling systems, polymers such as guar gum, gellan gum, xanthan gum, carrageenan, xyloglucan, pectin,
      chitosan, and thiolate chitosan are used. The gel produced by the in situ gelling technique is thinner than the
      duration of gastric retention. The main aim of this review is to focus on the in situ gel principle, classification,
      advantages, disadvantages, and its application as a floating in situ gel system.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4839
      Issue No: Vol. 17, No. 2 (2023)
  • Artificial Intelligence in Pharma Industry - A Review

    • Authors: Niyati Shah
      Abstract: The use of artificial intelligence (AI) in pharmaceutical technology has grown over time, and it may help save
      time and money while also improving our understanding of the connections between various formulations and
      process parameters. AI is a subfield of computer science called intelligence that focuses on the use of symbolic
      programming to solve problems. It has significantly developed into a problem-solving science with numerous
      applications in business, medicine, and engineering. The article discusses the development of novel peptides from
      natural foods, the treatment and management of rare diseases, drug adherence and dosage, and challenges to the
      adoption of AI in pharma. It also discusses manufacturing execution systems, automated control process systems,
      and AI to predict new treatments.
      Key words: ACPS, challenges to adoption
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4840
      Issue No: Vol. 17, No. 2 (2023)
  • Vaccine Adduct Microneedle Fabrication through 3D Printing Technology: A
           State-of-Art Review

    • Authors: Mamta Kumari
      Abstract: The use of attractive, minimally invasive puncture devices called microneedles (MNs) penetrates the skin without
      discomfort and enables the transdermal administration of active substances, including drugs and vaccines. MNs are
      also significant in disease diagnosis, monitoring, and cosmetics. MN geometry and shape are essential factors in
      affecting performance and therapeutic efficacy, whereas traditional manufacturing techniques including molding
      might not be able to enable fast design changes. In this regard, the manufacturing of MNs through the use of 3D
      printing technology allows for the quick and precise development of complicated MN prototypes as well as the
      availability of MN devices that may be configured to have the appropriate shape and dimension. Additionally,
      by combining MNs with 3D printing exhibits significant promise for the production of efficient transdermal
      drugs and vaccine delivery systems as well as medical devices. Unlike traditional intramuscular or subcutaneous
      delivery using hypodermic needles, MN-based vaccine created by 3D printing technology distributes vaccine
      directly into the skin, which is thought to be an immunologically far more relevant vaccination location than
      underlying tissue. The purpose of this review is to convey the benefits of using 3D printing technology as a novel
      tool for MN fabrication. Different 3D printing techniques are shown, and typical MNs produced using such
      techniques are highlighted in detail.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4841
      Issue No: Vol. 17, No. 2 (2023)
  • China-India Rivalry in Health Diplomacy: Issue in South Asia

    • Authors: Priyanka Tanwar
      Abstract: This paper focuses on China-India rivalry in health diplomacy in South Asia. To increase their geopolitical
      influence particularly in South Asia, both countries continue to prioritize health diplomacy in their foreign
      policies. China was given the responsibility for starting COVID-19, but concurrently, the same nation had taken
      advantage of the global-health crisis using its health diplomacy at global level as a soft power instrument for
      expanding its strategic influence in terms of hegemony. The paper also highlights the tussle between India and
      China for strategic influence in South Asia. This paper examines India and China’s global health diplomacy during
      COVID-19 particularly in South Asia. According to author, both countries compete with each other in South Asia.
      The author concludes that China utilized the COVID situation better than India to improve its relations with South
      Asian countries.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4842
      Issue No: Vol. 17, No. 2 (2023)
  • A Review on Herbal Approach to Treat Rheumatoid Arthritis

    • Authors: Dr. Rahul Trivedi
      Abstract: Rheumatoid arthritis (RA) is an autoimmune disorder. The disease mainly affects more than one joint in the
      body. Many people are affected by this disease worldwide. RA is a long-term progressive disorder with different
      stages. As the disease progresses, the condition of the joints gets worse and joint function terminates at last. It also
      affects other organs in the body. Many factors, including environmental, age, weight, genetics, and lifestyle, are
      responsible for RA. Several etiological factors, such as autoantibodies, inflammatory mediators, and genes, are
      responsible for the generation of RA. The symptoms of the disease include swelling, pain, loss of appetite, joint
      inflammation, fatigue, and pericarditis. The treatment objective for RA includes reducing pain and inflammation
      and preventing joint dysfunction as well as joint deformity. Various drugs, such as non-steroidal anti-inflammatory
      drugs, steroids, and disease-modifying anti-rheumatic drugs, are used to alleviate the symptoms of RA. The uses
      of synthetic drugs are associated with several life-threatening side effects. These side effects of synthetic drugs
      are the main thirst of peoples for searching alternative medicines in RA. The main objective of this study is to
      highlight the use of herbal medicines for RA for patient benefits. Herbal medicines and isolated phytoconstituents
      from herbal drugs have the advantages of low cost, easy availability, better patient acceptance, and very few side
      effects. These drugs also improve the patient’s condition and reduce stress. Many researchers have proven the
      efficacy of herbal drugs and phytoconstituents for RA patients. In this study, we are aiming to draw attention to
      the need to increase the use of herbal drugs for the treatment of RA.
      PubDate: 2023-06-15
      DOI: 10.22377/ajp.v17i2.4843
      Issue No: Vol. 17, No. 2 (2023)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762

Your IP address:
Home (Search)
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-