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- Evaluating combined effects of chronic, low-dose exposures of cadmium
(CLEC) and hyperglycemia on insulin signaling dysfunction in a
hepatocellular model-
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Abstract: Publication date: Available online 25 August 2024Source: ToxicologyAuthor(s): Rahul Kumar, Rama R. Gullapalli
- Artificial intelligence-based data extraction for next generation risk
assessment: Is fine-tuning of a large language model worth the effort'-
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Abstract: Publication date: Available online 23 August 2024Source: ToxicologyAuthor(s): Anna Sonnenburg, Benthe van der Lugt, Johannes Rehn, Paul Wittkowski, Karsten Bech, Florian Padberg, Dimitra Eleftheriadou, Todor Dobrikov, Hans Bouwmeester, Carla Mereu, Ferdinand Graf, Carsten Kneuer, Nynke I. Kramer, Tilmann Blümmel
- Exploring the Protective Potential of Nrf2 Overexpressed Neural
Extracellular Vesicles Against Cisplatin-induced Neurotoxicity via
NRF2/ARE Pathway-
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Abstract: Publication date: Available online 23 August 2024Source: ToxicologyAuthor(s): Derya Sağraç, Oğuz Kaan Kırbaş, Dilek Öztürkoğlu, Pınar Akku Süt, Pakize Neslihan Taşlı, Fikrettin Şahin
- Mutual regulation between histone methyltransferase Suv39h1 and the
Wnt/β-catenin signaling pathway promoted cell proliferation and inhibited
apoptosis in bone marrow mesenchymal stem cells exposed to hydroquinone-
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Abstract: Publication date: Available online 22 August 2024Source: ToxicologyAuthor(s): Tao Xu, Yilin Shen, Runmin Guo, Chiheng Luo, Yibo Niu, Zhilong Luo, Zhongxin Zhu, Zehui Wu, Xinyu Zhao, Hao Luo, Yuting Gao
- Evaluating the embryotoxicity of benzophenone-based photoinitiators in
stem cells and zebrafish embryos-
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Abstract: Publication date: Available online 17 August 2024Source: ToxicologyAuthor(s): Chen-Yi Weng, Tzu-Ching Chang, Jun-Yang Liou, Ju-Hsin Hsu, Chia-Chi Ho, Salim Arrokman, Pinpin Lin
- Unexpected antagonism of deoxynivalenol and enniatins in intestinal
toxicity through the Ras/PI3K/AKT signaling pathway-
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Abstract: Publication date: Available online 15 August 2024Source: ToxicologyAuthor(s): Yongli Ye, Luyao Tang, Jia-Sheng Wang, Lili Tang, Xiao Ning, Jiadi Sun, Lina Sheng, Xiulan Sun
- The zebrafish embryo as a model for chemically-induced steatosis: a case
study with three pesticides-
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Abstract: Publication date: Available online 14 August 2024Source: ToxicologyAuthor(s): Harm J. Heusinkveld, Edwin Zwart, Angela de Haan, Albert Braeuning, Jimmy Alarcan, Leo T.M. van der Ven
- Benzopyrene represses mitochondrial fission factors and
PINK1/Parkin-mediated mitophagy in primary astrocytes-
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Abstract: Publication date: November 2024Source: Toxicology, Volume 508Author(s): Yunn Me Me Paing, Yunkyung Eom, Sung Hoon Lee
- Alendronate sodium induces G1 phase arrest and apoptosis in human
umbilical vein endothelial cells by inhibiting ROS-mediated ERK1/2
signaling-
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Abstract: Publication date: November 2024Source: Toxicology, Volume 508Author(s): Yi Feng, Shao-Qin Tu, Yu-Luan Hou, Yi-Ting Shao, Lin Chen, Zhi-Hui Mai, Yu-Xuan Wang, Jia-Ming Wei, Sai Zhang, Hong Ai, Zheng Chen
- Investigating the cardiotoxicity of N-n-butyl haloperidol iodide:
Inhibition mechanisms on hERG channels-
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Abstract: Publication date: November 2024Source: Toxicology, Volume 508Author(s): Jilin Liao, Zhenyu Yang, Jinhua Yang, Hailing Lin, Bingxuan Chen, Hongbo Fu, Xiaojie Lin, Binger Lu, Fenfei Gao
- Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction
in offspring male rats by activating the RhoA/ROCK signalling pathway-
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Abstract: Publication date: Available online 14 August 2024Source: ToxicologyAuthor(s): Siyu Liu, Jianying Li, Wenhao Wang, Yijun Zhang, LI Shufeng, LI Tiewen, Juntao Jiang, Fujun Zhao
- CYP2E1 mediated deoxynivalenol-induced hepatocyte toxicity by regulating
ferroptosis-
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Abstract: Publication date: Available online 13 August 2024Source: ToxicologyAuthor(s): Qigui Mo, Chenchen Song, Yu Hua, Wei Wang, Aimei Liu
- The role of β2-AR/PI3K/AKT pathway in the proliferation, migration and
invasion of THLE-2 cells induced by nicotine-
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Abstract: Publication date: Available online 13 August 2024Source: ToxicologyAuthor(s): Yuqin Xu, Zihan He, Zihan Rao, Zihan Li, Yuxin Hu, Zhongwei Zhang, Jianming Zhou, Tong Zhou, Huai Wang
- Combining transcriptomics and metabolomics to assess neurodevelopmental
alteration caused by in utero exposure of mice to three putative thyroid
hormone system disruptors-
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Abstract: Publication date: Available online 11 August 2024Source: ToxicologyAuthor(s): Yanis Zekri, Rikke Poulsen, Martin Hansen, Frédéric Flamant, Romain Guyot
- Machine Learning-Driven QSAR Models for Predicting the Cytotoxicity of
Five Common Microplastics-
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Abstract: Publication date: Available online 11 August 2024Source: ToxicologyAuthor(s): Chengzhi Liu, Cheng Zong, Shuang Chen, Jiangliang Chu, Yifan Yang, Yong Pan, Beilei Yuan, Huazhong Zhang
- Urinary GM2AP coincides with renal cortical damage and grades cisplatin
nephrotoxicity severity in rats-
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Abstract: Publication date: Available online 11 August 2024Source: ToxicologyAuthor(s): Víctor Blanco-Gozalo, Yaremi Quiros, Laura Vicente-Vicente, Alfredo G. Casanova, Sandra M. Sancho-Martínez, Francisco J. López-Hernández
- Effects of Isochlorogenic Acid A on Mitochondrial Dynamics Imbalance and
RLR Damage in PAM Cells Induced by Combined Mycotoxins-
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Abstract: Publication date: Available online 11 August 2024Source: ToxicologyAuthor(s): Xinuo Lai, Peng Fan, Huidan Deng, Guilin Jia, Zhicai Zuo, Yanchun Hu, Ya Wang, Dongjie Cai, Liping Gou, Yiping Wen, Shumin Yu, Suizhong Cao, Liuhong Shen, Junliang Deng, Zhihua Ren
- Hexavalent chromium reduces testosterone levels by impairing lipophagy and
disrupting lipid metabolism homeostasis: based on a metabolomic analysis-
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Abstract: Publication date: Available online 8 August 2024Source: ToxicologyAuthor(s): Qian Xue, Le Zhang, Rui Wang, Jiayunzhu Xu, Chaofan Wang, Shidi Gao, Xin Fang, Chunyang Meng, Rifeng Lu, Li Guo
- Exosomes-mediated retinoic acid disruption: A link between gut microbiota
depletion and impaired spermatogenesis-
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Abstract: Publication date: Available online 8 August 2024Source: ToxicologyAuthor(s): Tong Chen, Boqi Zhang, Guitian He, Caomeihui Shen, Nan Wang, Jinxin Zong, Xue Chen, Lu Chen, Chunjin Li, Xu Zhou
- Proteasome Inhibition Induces Apoptosis Through Simultaneous Inactivation
of MCL-1/BCL-XL by NOXA Independent of CHOP and JNK Pathways-
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Abstract: Publication date: Available online 6 August 2024Source: ToxicologyAuthor(s): Wenjuan Chen, Mengning Sun, Yi Sun, Qinglan Yang, Hui Gao, Li Li, Rongrong Fu, Na Dong
- A review on e-waste contamination, toxicity, and sustainable clean-up
approaches for its management-
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Abstract: Publication date: Available online 4 August 2024Source: ToxicologyAuthor(s): Pankaj Kumar, Snigdha Singh, Amel Gacem, Krishna Kumar Yadav, Javed Khan Bhutto, Maha Awjan Alreshidi, Manoj Kumar, Anand Kumar, Virendra Kumar Yadav, Sunil Soni, Ramesh Kumar, Maytham T. Qasim, Mohd. Tariq, Mir Waqas Alam
- Drug-induced enzyme activity inhibition and CYP3A4 genetic polymorphism
significantly shape the metabolic characteristics of furmonertinib-
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Abstract: Publication date: Available online 3 August 2024Source: ToxicologyAuthor(s): Qi Zhou, Zhize Ye, Xiaoyu Xu, Yunshan Zhong, Jianchao Luo, Zheyan Zhang, Jing Chen, Zhongxi Chen, Jianping Cai, Xiaodan Zhang, Jianchang Qian
- An In-depth Examination of Per- and Polyfluoroalkyl (PFAS) Effects on
Transporters, with Emphasis on the ABC Superfamily: A Critical Review-
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Abstract: Publication date: Available online 31 July 2024Source: ToxicologyAuthor(s): Gracen E. Collier, Ramon Lavado
- Assessment of Cytotoxic and Genotoxic Effects of Glyphosate-Based
Herbicide on Glioblastoma Cell Lines: Role of p53 in Cellular Response and
Network Analysis-
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Abstract: Publication date: Available online 31 July 2024Source: ToxicologyAuthor(s): Kelly Louise Thiel, Juliana da Silva, Micaele Wolfarth, Julia Vanini, João Antonio Pêgas Henriques, Iuri Marques de Oliveira, Fernanda Rabaioli da Silva
- Insights gained into the injury mechanism of drug and herb induced liver
injury in the hepatic microenvironment-
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Abstract: Publication date: September 2024Source: Toxicology, Volume 507Author(s): Xiaomeng Zhang, Qi Geng, Lin Lin, Lulu Zhang, Changqi Shi, Bin Liu, Lan Yan, Zhiwen Cao, Li Li, Peipei Lu, Yong Tan, Xiaojuan He, Ning Zhao, Li Li, Cheng Lu
- HMGA2-mediated glutamine metabolism is required for Cd-induced cell growth
and cell migration-
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Abstract: Publication date: Available online 19 July 2024Source: ToxicologyAuthor(s): Yanqiu Yang, Chunpeng Gao, Qiujuan Li, Yong Liu, Jun Cao
- Bisphenol S (BPS) induces glioblastoma progression via regulation of
EZH2-mediated PI3K/AKT/mTOR pathway in U87-MG cells-
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Abstract: Publication date: Available online 18 July 2024Source: ToxicologyAuthor(s): Moon Yi Ko, Heejin Park, Younhee Kim, Euijun Min, Sin-Woo Cha, Byoung-Seok Lee, Sung-Ae Hyun, Minhan Ka
- How does organophosphorus chemical warfare agent exposure affect
respiratory physiology in mice'-
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Abstract: Publication date: Available online 17 July 2024Source: ToxicologyAuthor(s): Trancart Marilène, Botta Antoine, Le Coz Christine, Guatto Nathalie, Calas André-Guilhem, Hanak Anne-Sophie
- Targeting SIRT1/AMPK/Nrf2/NF-кB by sitagliptin protects against oxidative
stress-mediated ER stress and inflammation during ANIT-induced cholestatic
liver injury-
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Abstract: Publication date: Available online 17 July 2024Source: ToxicologyAuthor(s): Rami M. Mosaoa, Mohammed W. Al-Rabia, Hani Z. Asfour, Nabil A. Alhakamy, Rasha A. Mansouri, Dina S. El-Agamy, Wesam H. Abdulaal, Gamal A. Mohamed, Sabrin R.M. Ibrahim, Mahmoud Elshal
- Study on the mechanisms of defective spermatogenesis induced by TiO2 NPs
based on 3D blood−testis barrier microfluidic chip-
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Abstract: Publication date: Available online 15 July 2024Source: ToxicologyAuthor(s): Ruoyun Dong, Li Li, Hongmei Chang, Guanling Song, Sixiu Liu
- Methylglyoxal-derived hydroimidazolone-1/RAGE axis induces renal oxidative
stress and renal fibrosis in vitro and in vivo-
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Abstract: Publication date: Available online 15 July 2024Source: ToxicologyAuthor(s): Gyuri Kim, Hee Joon Yoo, Min Ki Yoo, Ju Hyeong Choi, Kwang-Won Lee
- Benzo(a)pyrene promotes the malignant progression of malignant-transformed
BEAS-2B cells by regulating YTH N6-methyladenosine RNA binding protein 1
to inhibit ferroptosis-
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Abstract: Publication date: Available online 14 July 2024Source: ToxicologyAuthor(s): Na Wang, Hong-qiang Chen, Yong Zeng, Yu Shi, Zhe Zhang, Jiang-ying Li, Shi-meng Zhou, Ya-wen Li, Shuang-wu Deng, Xue Han, Zi-yuan Zhou, Mao-lin Yao, Wen-bin Liu
- Developments in the field of intestinal toxicity and signaling pathways
associated with rodent exposure to micro(nano)plastics-
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Abstract: Publication date: Available online 11 July 2024Source: ToxicologyAuthor(s): Lixia Du, Hong Liu, Xuan Song, Xiaoqian Feng, Hui Xu, Wei Tang, Jie Yang
- Evidence for enduring cardiac and multiorgan toxicity after repeated
exposure to the synthetic cannabinoid JWH-018 in male rats-
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Abstract: Publication date: Available online 6 July 2024Source: ToxicologyAuthor(s): Nicholas Pintori, Maria Pina Serra, Antonio Carai, Carla Lobina, Raffaella Isola, Roberta Noli, Gessica Piras, Enrica Spano, Michael H Baumann, Marina Quartu, Maria Antonietta De Luca
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