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- Comparison of PAC and MOAH for understanding the carcinogenic and
developmental toxicity potential of mineral oils-
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Abstract: Publication date: Available online 23 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Juan-Carlos Carrillo, Lenny Kamelia, Julija Romanuka, Olaf Kral, Allison Isola, Helena Niemelä, Anna Steneholm
- Acute and 28-day repeated dose toxicity evaluations of cold pressed Pinus
halepensis Mill. seed oil in mice and rats-
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Abstract: Publication date: Available online 22 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Sihem Ait Atmane, Djedjiga Ait Eldjoudi, Zeynep Aksoylu Özbek, Pelin Günç Ergönül, Bachra Khettal
- Evaluation of interactions in chemical mixtures containing cyanides
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Abstract: Publication date: Available online 21 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Hana Pohl, Moiz Mumtaz
- Development of COVID-19 therapies: Nonclinical testing considerations
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Abstract: Publication date: Available online 21 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Paul Baldrick
- An OECD TG 428 study ring trial with 14C-Caffeine demonstrating
repeatability and robustness of the dermal absorption in vitro method-
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Abstract: Publication date: Available online 13 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Felix M. Kluxen, Styliani Totti, Wilfred Maas, Frank Toner, Leanne Page, Kathryn Webbley, Rajendra Nagane, Robert Mingoia, Christine Whitfield, John Kendrick, Claire Valentine, Jeanne Bernal Dorange, Camille Egron, Camille Imart, Jeanne Y. Domoradzki, Philip Fisher, Christine Lorez, Steve McEuen, Edgars Felkers, Tao Chen
- Corrigendum to “Histopathology re-examination of the NTP
toxicity/carcinogenicity studies of tert-butyl alcohol to identify renal
tumor and toxicity modes of action” [Regul. Toxicol. Pharmacol. 102
(2019) 65–73]-
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Abstract: Publication date: Available online 11 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Gordon C. Hard, Samuel M. Cohen, Jihyun Ma, Fang Yu, Lora L. Arnold, Marcy I. Banton
- Dose response effect of chemical surface concentration on percutaneous
penetration in human: In vivo + in vitro-
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Abstract: Publication date: Available online 10 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Le H.D. Do, Rebecca M. Law, Howard I. Maibach
- The Conundrum of the PFOA human half-life, an international collaboration
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Abstract: Publication date: Available online 7 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Jerry Campbell, Harvey Clewell, Tony Cox, Michael Dourson, Shannon Ethridge, Norman Forsberg, Bernard Gadagbui, Ali Hamade, Ravi Naidu, Nathan Pechacek, Tiago Severo Peixe, Robyn Prueitt, Mahesh Rachamalla, Lorenz Rhomberg, James Smith, Nitin Verma
- Comparison of toxicological effects and exposure levels between triclosan
and its structurally similar chemicals using in vitro tests for
read-across case study-
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Abstract: Publication date: Available online 6 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Shota Nakagawa, Akane Hayashi, Yuko Nukada, Masayuki Yamane
- Read-across and new approach methodologies applied in a 10-step framework
for cosmetics safety assessment – A case study with parabens-
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Abstract: Publication date: Available online 1 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Gladys Ouedraogo, Camilla Alexander-White, Dagmar Bury, Harvey J. Clewell, Mark Cronin, Tom Cull, Matthew Dent, Bertrand Desprez, Ann Detroyer, Corie Ellison, Stefania Giammanco, Eric Hack, Nicola J. Hewitt, Gerry Kenna, Martina Klaric, Reinhard Kreiling, Cathy Lester, Catherine Mahony, Enrico Mombelli, Jorge Naciff
- Characterization of population variability of 1,3-butadiene derived
protein adducts in humans and mice-
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Abstract: Publication date: July 2022Source: Regulatory Toxicology and Pharmacology, Volume 132Author(s): Gunnar Boysen, Ivan Rusyn, Weihsueh A. Chiu, Fred A. Wright
- Results from two-year rodent oral carcinogenicity studies of cizolirtine,
a substance-P and calcitonin gene-related peptide release modulator-
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Abstract: Publication date: Available online 29 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Antonio Guzmán, Araceli Tortajada, Ana-Paz Marín, Cristina Vila, Gregorio Encina
- TSCA risk evaluation-directed characterization of occupational exposures
during formaldehyde manufacturing, use as an intermediate, and compounding
of formaldehyde-based polymers-
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Abstract: Publication date: Available online 25 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): James H. Sherman, Gary M. Rowen, J. Tyler Tanniehill
- Corrigendum to a cross-industry collaboration to assess if acute toxicity
(Q)SAR models are fit-for-purpose for GHS classification and labelling.
Regulatory toxicology and pharmacology (2021) 104843-
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Abstract: Publication date: Available online 23 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Joel Bercu, Melisa J. Masuda Herrera, Alejandra Trejo-Martin, Catrin Hasselgren, Jean Lord, Jessica Graham, Matthew Schmitz, Lawrence Milchak, Colin Owens, Surya Hari Lal, Richard Marchese Robinson, Sarah Whalley, Phillip Bellion, Anna Vuorinen, Kamila Gromek, William A. Hawkins, Iris Van de Gevel, Kathleen Vriens, Raymond Kemper, Russell Naven
- Review of air concentrations of pesticides for estimating exposure to
vapour in European risk assessments-
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Abstract: Publication date: Available online 22 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Edgars Felkers, Felix M. Kluxen, Sarah Adham, Anne-Kim Vinck, Neil Morgan
- Residue depletion profiles and withdrawal interval estimations of
meloxicam in eggs and ovarian follicles following intravenous (Meloxicam
solution for injection) and oral (Meloxidyl®) administration in domestic
chickens (Gallus domesticus)-
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Abstract: Publication date: Available online 20 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Long Yuan, Zhoumeng Lin, Rachel S. Dutch, Emily D. Richards, Maaike O. Clapham, Nathaniel Burmas, Scott E. Wetzlich, Lisa A. Tell
- Expansion of the Cosmetics Europe skin sensitisation database with new
substances and PPRA data-
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Abstract: Publication date: Available online 18 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Sebastian Hoffmann, Nathalie Alépée, Nicola Gilmour, Petra S. Kern, Erwin van Vliet, Fanny Boislève, Dagmar Bury, Elodie Cloudet, Martina Klaric, Jochen Kühnl, Jon F. Lalko, Karsten Mewes, Masaaki Miyazawa, Hayato Nishida, Mai Thanh Tam Brami, Mustafa Varçin, Anne Marie Api, Cosmetics Europe
- Prenatal developmental toxicity study of 2,4-dichlorobenzyl alcohol in
rats-
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Abstract: Publication date: Available online 14 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Kyeong-Nang Moon, Sang-Ki Baek, Woojin Kim, Ji-Seong Jeong, Byoung-Seok Lee, Yixian Quah, Jinsoo Lee, Sang Yun Kim, Seung-Jin Lee, Kyu-Bong Kim, Wook-Joon Yu
- Preclinical safety assessment of toxicity and biodistribution of oncolytic
virus HSV-1 expressing human PD-1 antibody in mice-
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Abstract: Publication date: Available online 9 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Xin Wang, Chao Wang, Zhe Qu, Chao Tian, Tiantian Wang, Yufa Miao, Hua Jiang, Lulu Li, Jiajia Liu, Rui Zhao, Xiaopeng Li, Xingchao Geng
- Integration of toxicodynamic and toxicokinetic new approach methods into a
weight-of-evidence analysis for pesticide developmental neurotoxicity
assessment: A case-study with DL- and L-glufosinate-
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Abstract: Publication date: Available online 9 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Sarah Dobreniecki, Elizabeth Mendez, Anna Lowit, Theresa M. Freudenrich, Kathleen Wallace, Amy Carpenter, Barbara A. Wetmore, Anna Kreutz, Evgenia Korol-Bexell, Katie Paul Friedman, Timothy J. Shafer
- Cobalt: A tiered testing strategy to estimate its inhalation toxicity
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Abstract: Publication date: Available online 5 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Michael Dourson, Brent Finley
- Report on investigation of ISO 10993–12 extraction conditions
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Abstract: Publication date: Available online 2 April 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Theodore Heise, Anita Y. Sawyer, Toshiyuki Hirai, Sandi Schaible, Harmony Sy, Samanthi Wickramasekara
- Characterization of false positive, contaminant-driven mutagenicity in
impurities associated with the sotorasib drug substance-
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Abstract: Publication date: Available online 21 March 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Aldo Coppi, Rhian Davies, Teresa Wegesser, Katsu Ishida, Jamie Karmel, Jun Han, Frankie Aiello, Yong Xie, Michael T. Corbett, Andrew T. Parsons, Thomas M. Monticello, Sheroy Minocherhomji
- Applicability of nanomaterial-specific guidelines within long-term Daphnia
magna toxicity assays: A case study on multigenerational effects of nTiO2
and nCeO2 exposure in the presence of artificial daylight-
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Abstract: Publication date: Available online 20 March 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Tom A.P. Nederstigt, Willie J.G.M. Peijnenburg, Eric A.J. Bleeker, Martina G. Vijver
- Absence of developmental or reproductive toxicity in rats for MB-102, a
fluorescent tracer agent for point-of-care measurement of glomerular
filtration rate-
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Abstract: Publication date: Available online 19 March 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Joseph E. Bugaj, Richard B. Dorshow
- Rethinking chronic toxicity and carcinogenicity assessment for
agrochemicals project (ReCAAP): A reporting framework to support a weight
of evidence safety assessment without long-term rodent bioassays-
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Abstract: Publication date: Available online 17 March 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Gina M. Hilton, Catherine Adcock, Gregory Akerman, James Baldassari, Michael Battalora, Warren Casey, Amy J. Clippinger, Rhian Cope, Amber Goetz, A. Wallace Hayes, Sabitha Papineni, Richard C. Peffer, Deborah Ramsingh, Brandy Williamson Riffle, Mitscheli Sanches da Rocha, Natalia Ryan, Edward Scollon, Nicolo Visconti, Douglas C. Wolf, Zhongyu Yan
- Next generation risk assessment for skin allergy: Decision making using
new approach methodologies-
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Abstract: Publication date: Available online 17 March 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): N. Gilmour, J. Reynolds, K. Przybylak, M. Aleksic, N. Aptula, M.T. Baltazar, R. Cubberley, R. Rajagopal, G. Reynolds, S. Spriggs, C. Thorpe, S. Windebank, G. Maxwell
- A framework to mitigate the risk of chemical leukoderma: Consumer products
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Abstract: Publication date: Available online 12 March 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Donald L. Bjerke, Shengde Wu, Kazumasa Wakamatsu, Shosuke Ito, Jiazhen Wang, Timothy Laughlin, Tomohiro Hakozaki
- Isoflucypram: Combining in vivo and NAMs data in a weight of evidence
approach to demonstrate the human non-relevance of the mode of action
leading to the subtle thyroid effects observed in the rat-
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Abstract: Publication date: Available online 8 March 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): H. Tinwell, R. Bars
- A scoping review of infant and children health effects associated with
cadmium exposure-
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Abstract: Publication date: Available online 4 March 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Brenna M. Flannery, Heather R. Schaefer, Karlyn B. Middleton
- R-ODAF: Omics data analysis framework for regulatory application
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Abstract: Publication date: Available online 3 March 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Marcha CT. Verheijen, Matthew J. Meier, Juan Ochoteco Asensio, Timothy W. Gant, Weida Tong, Carole L. Yauk, Florian Caiment
- Human exposure to toxic elements through facial cosmetic products: Dermal
risk assessment-
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Abstract: Publication date: Available online 24 February 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Asma Akhtar, Tasneem Gul Kazi, Hassan Imran Afridi, Mustafa Khan
- “From Protein Toxins to Applied Toxicological Testing” virtual
workshop identifies the need for a bioinformatic framework to assess novel
food protein safety-
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Abstract: Publication date: Available online 24 February 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Patricia A. Bauman, Andrew C. Doxey, Ivano Eberini, Emir Islamovic, Florence Jungo, Colton Kessenich, John Kough, Mansi Krishan, Luca Palazzolo, Laura Privalle, Chester Rodriguez, Karla Satchell, Andre Silvanovich, Lucilia Pereira Mouriès
- Standardization, in-silico and in-vivo safety assessment of methanol
extract of Ziziphus mauritiana Lam leaves-
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Abstract: Publication date: Available online 24 February 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Mohan Kumar Ramar, Kumarappan Chidambaram, Balakumar Chandrasekaran, Ruckmani Kandasamy
- Use of in vitro metabolism and biokinetics assays to refine predicted in
vivo and in vitro internal exposure to the cosmetic ingredient,
phenoxyethanol, for use in risk assessment-
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Abstract: Publication date: Available online 22 February 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Nicola J. Hewitt, John Troutman, Julia Przibilla, Andreas Schepky, Gladys Ouédraogo, Catherine Mahony, Gerry Kenna, Mustafa Varçin, Mathew P. Dent, Cosmetics Europe
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