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- Letter to the editors regarding “The conundrum of the PFOA human
half-life, an international collaboration.”-
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Abstract: Publication date: Available online 13 August 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Gloria B. Post, Linda S. Birnbaum, Jamie C. DeWitt, Helen Goeden, Wendy J. Heiger-Bernays, Jennifer J. Schlezinger
- Response to Letter to Editor “Letter to the editors regarding “The
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Abstract: Publication date: Available online 12 August 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Jerry Campbell, Harvey Clewell, Tony Cox, Michael Dourson, Shannon Ethridge, Norman Forsberg, Bernard Gadagbui, Ali Hamade, Ravi Naidu, Nathan Pechacek, Tiago Severo Peixe, Robyn Prueitt, Mahesh Rachamalla, Lorenz Rhomberg, James Smith, Nitin Verma
- Setting impurity limits for endogenous substances: Recommendations for a
harmonized procedure and an example using fatty acids-
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Abstract: Publication date: Available online 11 August 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Robert A. Jolly, Suren Bandara, Joel Bercu, Courtney M. Callis, David G. Dolan, Jessica Graham, Diem HaMai, Ester Lovsin Barle, Andrew Maier, Melisa Masuda-Herrera, Chandrika Moudgal, Jillian A. Parker, John Reichard, Reena Sandhu, Ernest S. Fung
- First-in-human study to evaluate the safety, tolerability and
pharmacokinetics of a novel analgesic and antipyretic drug with structural
similarity to acetaminophen-
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Abstract: Publication date: Available online 5 August 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Cathy K. Gelotte, Amy M. Vakil, Joris Berwaerts, Brenda A. Zimmerman, Gary E. Eichenbaum, Christopher M. Flores, Edwin K. Kuffner
- Amphibian Metamorphosis Assay: Investigation of the potential effects of
five chemicals on the hypothalamic-pituitary thyroid axis of Xenopus
laevis-
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Abstract: Publication date: Available online 5 August 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Alaa Kamel, Sharlene R. Matten, Scott G. Lynn, Jeffrey C. Wolf, Douglas J. Fort
- Case study on the impact of the source of metabolism parameters in next
generation physiologically based pharmacokinetic models: Implications for
occupational exposures to trimethylbenzenes-
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Abstract: Publication date: Available online 3 August 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Lisa M. Sweeney
- Reference Chemical Potency List (RCPL): A new tool for evaluating the
accuracy of skin sensitisation potency measurements by New Approach
Methodologies (NAMs)-
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Abstract: Publication date: Available online 3 August 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Amaia Irizar, Hans Bender, Peter Griem, Andreas Natsch, Matthias Vey, Ian Kimber
- Use of biomarker data and metabolite relative potencies to support
derivation of noncancer reference values based on the reproductive and
developmental toxicity effects of 1,3-butadiene-
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Abstract: Publication date: Available online 1 August 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): C.R. Kirman, C.M. North, N.Y. Tretyakova, N. Erraguntla, H. Shen, S.M. Hays
- Sub-structure-based category formation for the prioritisation of
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Abstract: Publication date: Available online 31 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): S.J. Enoch, Z. Hasarova, M.T.D. Cronin, M. Frericks
- 10% Body weight (gain) change as criterion for the maximum tolerated dose:
A critical analysis-
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Abstract: Publication date: Available online 30 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Damiën van Berlo, Marjolijn Woutersen, Andre Muller, Marja Pronk, Jelle Vriend, Betty Hakkert
- Corrigendum to “Biomonitoring Equivalents for Molybdenum” [Regul.
Toxicol. Pharmacol. 77 (2016) 223–229]-
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Abstract: Publication date: Available online 20 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Sean M. Hays, Kristin Macey, Devika Poddalgoda, Ming Lu, Andy Nong, Lesa L. Aylward
- Current trends in safety assessment of cosmetics ingredients
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Abstract: Publication date: Available online 19 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Elisabet Berggren
- Toxicological assessment compilation of selected examples of raw materials
for homeopathic and anthroposophic medicinal products – Part 2-
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Abstract: Publication date: Available online 13 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Marie-Luise Buchholzer, Marion Kirch, Christiane Kirchner, Werner Knöss
- Decision making in next generation risk assessment for skin allergy: Using
historical clinical experience to benchmark risk-
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Abstract: Publication date: Available online 12 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): J. Reynolds, N. Gilmour, M.T. Baltazar, G. Reynolds, S. Windebank, G. Maxwell
- Pharmaceutical excipients with potential to cause adverse effects in
paediatric nasal medicines-
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Abstract: Publication date: Available online 9 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Ana N. Stjepanovic, Nemanja B. Todorovic, Tamara Z. Tesic, Zoran S. Komazec, Jelena M. Canji-Panic, Mladena N. Lalic-Popovic
- Monosodium glutamate in a type 2 diabetes context: A large scoping review
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Abstract: Publication date: Available online 9 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Jana El Tabbal
- The utility of hERG channel inhibition data in the derivation of
occupational exposure limits-
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Abstract: Publication date: Available online 9 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Jillian A. Parker, Ernest S. Fung, Alejandra Trejo-Martin, Lisa Liang, Katherine Gibbs, Suren Bandara, Stephanie Chen, Reena Sandhu, Joel Bercu, Andrew Maier
- The ability of sweat and buffer solutions to reduce hexavalent chromium of
relevance for leather extraction-
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Abstract: Publication date: Available online 8 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Alexandra Wright, Lila Laundry-Mottiar, Yolanda S. Hedberg
- Grouping of PFAS for human health risk assessment: Findings from an
independent panel of experts-
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Abstract: Publication date: Available online 8 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): J.K. Anderson, R.W. Brecher, I.T. Cousins, J. DeWitt, H. Fiedler, K. Kannan, C.R. Kirman, J. Lipscomb, B. Priestly, R. Schoeny, J. Seed, M. Verner, S.M. Hays
- Corrigendum to “An OECD TG 428 study ring trial with 14C-Caffeine
demonstrating repeatability and robustness of the dermal absorption in
vitro method” [Regul. Toxicol. Pharmacol. 132 (2022) 105184]-
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Abstract: Publication date: Available online 8 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Felix M. Kluxen, Styliani Totti, Wilfred Maas, Frank Toner, Leanne Page, Kathryn Webbley, Rajendra Nagane, Robert Mingoia, Christine Whitfield, John Kendrick, Claire Valentine, Jeanne Bernal Dorange, Camille Egron, Camille Imart, Jeanne Y. Domoradzki, Philip Fisher, Christine Lorez, Steve McEuen, Edgars Felkers, Tao Chen
- Application of a new approach method (NAM) for inhalation risk assessment
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Abstract: Publication date: Available online 8 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Tharacad Ramanarayanan, Arpad Szarka, Sheila Flack, Paul Hinderliter, Richard Corley, Alex Charlton, Sharlyne Piles, Douglas Wolf
- Toxicity assessment and health hazard classification of stainless steels
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Abstract: Publication date: Available online 8 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Piia Taxell, Pasi Huuskonen
- In vitro and in vivo evaluation of probiotic potential and safety
assessment of Bacillus coagulans SKB LAB-19 (MCC 0554) in humans and
animal healthcare-
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Abstract: Publication date: Available online 3 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Khushal Chaudhari, Mahalaxmi Mohan, Parag Saudagar, Chetna Sable, Sominath Shinde, Dattatray Bedade
- Preclinical safety evaluation of the ethanolic extract from the aerial
parts of Gomphrena celosioides Mart. In rodents-
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Abstract: Publication date: Available online 2 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Luis Fernando Benitez Macorini, Rafael Souza Maris, Thiago Chaves Teixeira, Caren Naomi Aguero Ito, Angela Midori Kuraoka-Oliveira, Flávia Barbieri Bacha, Angela Julieth Buitrago Mejia, Marcos José Salvador, Cândida Aparecida Leite Kassuya, Arielle Cristina Arena
- Richardia brasiliensis Gomes: phytochemical characterization,
antiproliferative capacity and in vitro and in vivo toxicity-
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Abstract: Publication date: Available online 2 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Rafaela Castro Dornelles, Camille Gaube Guex, Rachel de Lima, Daniele Rubert Nogueira-Librelotto, Rosana Casoti, Ana Martiele Engelmann, Camila Benaduce Emanuelli Mello, Julia Brandt de Souza, Cinthia Melazzo de Andrade, Alencar Kolinski Machado, Micheli Mainardi Pillat, Melânia Palermo Manfron, Liliane de Freitas Bauermann
- Toxicological assessment of enzyme-treated Zizania latifolia extract: Oral
toxicology and genotoxicity in rats-
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Abstract: Publication date: Available online 2 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Se-Ho Park, Cho Young Lim, Joo Myung Moon, Jung Eun Gwag, Jae-Yeul Lee, Seun-Ah Yang
- Acute and sub chronic toxicity studies with herbal pain relieving formula
(Rhuleave-K™) in rats-
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Abstract: Publication date: Available online 1 July 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Benny Antony, Merina Benny, Binu T. Kuruvilla, Nishant Kumar Gupta, Sherina Jacob
- A bioinformatics framework for targeted gene expression assay design:
Application to in vitro developmental neurotoxicity screening in a rat
model-
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Abstract: Publication date: Available online 17 June 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Bhaja K. Padhi, Manjeet Singh, Guillaume Pelletier
- Comparison of the lower limit of benchmark dose confidence interval with
no-observed-adverse-effect level by applying four different software for
tumorigenicity testing of pesticides in Japan-
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Abstract: Publication date: August 2022Source: Regulatory Toxicology and Pharmacology, Volume 133Author(s): Yukuto Yasuhiko, Miwa Ishigami, Satoshi Machino, Tatsuya Fujii, Masanori Aoki, Fumi Irie, Yasunari Kanda, Midori Yoshida
- Physiologically based pharmacokinetic combined JAK2 occupancy modelling to
simulate PK and PD of baricitinib with kidney transporter inhibitors and
in patients with hepatic/renal impairment-
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Abstract: Publication date: Available online 11 June 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Zhongjian Wang, Wei Liu, Xueyan Li, Hongjiao Chen, Dongying Qi, Fulu Pan, Huining Liu, Shuang Yu, Bowen Yi, Guopeng Wang, Yang Liu
- A double-blind, randomized, two-part, two-period crossover study to
evaluate the pharmacokinetics of caffeine versus d9-Caffeine in healthy
subjects-
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Abstract: Publication date: Available online 8 June 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Mary M. Sherman, Paul M. Tarantino, Dennis N. Morrison, Chun-Han Lin, Ryan M. Parente, Bradford C. Sippy
- Updated interim reference levels for dietary lead to support FDA's closer
to zero action plan-
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Abstract: Publication date: Available online 8 June 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Brenna M. Flannery, Karlyn B. Middleton
- Current ecotoxicity testing needs among selected U.S. federal agencies
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Abstract: Publication date: Available online 2 June 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Patricia Ceger, Natalia Garcia-Reyero Vinas, David Allen, Elyssa Arnold, Raanan Bloom, Jennifer C. Brennan, Carol Clarke, Karen Eisenreich, Kellie Fay, Jonathan Hamm, Paula F.P. Henry, Katherine Horak, Wesley Hunter, Donna Judkins, Patrice Klein, Nicole Kleinstreuer, Kara Koehrn, Carlie A. LaLone, James P. Laurenson, Jessica K. Leet
- Quantitative measurement of harmful and potentially harmful constituents,
pH, and moisture content in 16 commercial smokeless tobacco products-
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Abstract: Publication date: Available online 1 June 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Selvin H. Edwards, Matthew D. Hassink, Kenneth M. Taylor, An T. Vu
- Updating the Dermal Sensitisation Thresholds using an expanded dataset and
an in silico expert system-
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Abstract: Publication date: Available online 1 June 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Martyn L. Chilton, Anne Marie Api, Robert S. Foster, G. Frank Gerberick, Maura Lavelle, Donna S. Macmillan, Mihwa Na, Devin O'Brien, Catherine O'Leary-Steele, Mukesh Patel, David J. Ponting, David W. Roberts, Robert J. Safford, Rachael E. Tennant
- Assessment of the applicability of the threshold of toxicological concern
for per- and polyfluoroalkyl substances-
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Abstract: Publication date: Available online 1 June 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Isabel Lea, Ly Ly Pham, Todor Antonijevic, Chad Thompson, Susan J. Borghoff
- Comparison of product safety data sheet ingredient lists with skin
irritants and sensitizers present in a convenience sample of light-curing
resins used in additive manufacturing-
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Abstract: Publication date: Available online 31 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Lauren N. Bowers, Anand C. Ranpara, Katherine A. Roach, Alycia K. Knepp, Elizabeth D. Arnold, Aleksandr B. Stefaniak, M. Abbas Virji
- Safety assessment of MPTA: An oral acute and 90-day sub-chronic toxicity
study in Sprague-Dawley rats-
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Abstract: Publication date: Available online 27 May 2022Source: Regulatory Toxicology and PharmacologyAuthor(s): Zhen Dong, Shu-sheng Tang, Chang-hong Li, Zhao-shan Tang, Zi-hui Yang, Jian-guo Zeng
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