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- Extracts of Prunella vulgaris Enhanced Pentobarbital-Induced Sleeping
Behavior in Mice Potentially via Adenosine A2A Receptor Activity-
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Authors: Sayson; Leandro Val, Campomayor, Nicole Bon, Ortiz, Darlene Mae, Lee, Hyun Jun, Balataria, Sweetie, Park, Sangsu, Lim, Jeongin, Kang, Heejin, Kim, Hee Jin, Kim, Mikyung
Abstract: The increasing prevalence of sleep dysregulation cases has prompted the search for effective and safe sleep-enhancing agents. Numerous medications used in the treatment of sleep disorders function by enhancing γ-aminobutyric acid neurotransmitter activity. Unfortunately, these substances may induce significant adverse effects in chronic users, such as dependence and motor behavior impairments. Consequently, there is a growing interest in exploring therapeutic sleep-enhancing agents derived from natural sources, with the anticipation of causing less severe side effects. Prunella vulgaris (PV), a perennial plant indigenous to South Korea, exhibits various pharmacological effects, likely attributed to its chemical composition. Rosmarinic acid, one of its components, has previously demonstrated sleep-potentiating properties, suggesting the potential for PV to exhibit similar pharmacological effects. This study aims to investigate the potential effects of repeated administration of PV extract on the sleep behavior, brainwave activity, sleep–wake cycle, and physiological behavior of mice. Findings indicate that PV extracts exhibit sleep-enhancing effects in mice, characterized by prolonged sleep duration and a reduced onset time of pentobarbital-induced sleep. However, PV extracts only reduced alpha wave powers, with minor alterations in wakefulness and rapid-eye-movement sleep duration. In contrast to diazepam, PV extracts lack adverse effects on locomotor activity, motor coordination, or anxiety in mice. Receptor-binding assay and caffeine treatment support the potential involvement of adenosine A2A receptors in the effects of PV, suggesting distinct mechanisms of action compared to diazepam, despite both exhibiting sleep-altering effects. Overall, our results suggest that PV holds promise as a potential source of sleep-aiding agents.
Citation: Planta Med ; : -
PubDate: 2024-07-24T11:58:57+01:00
DOI: 10.1055/a-2360-9639
- Cocoa Butter: Evolution from Natural Food Ingredient to Pharmaceutical
Excipient and Drug Delivery System-
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Authors: Loke; Ying Hui, Phang, Hiu Ching, Mohamad, Najwa, Kee, Phei Er, Chew, Yik-Ling, Lee, Siew-Keah, Goh, Choon Fu, Yeo, Chien Ing, Liew, Kai Bin
Abstract: For decades, cocoa butter has been extensively used in food industries, particularly in the production of chocolate confectioneries. The composition of fats within cocoa butter, such as stearic acid, palmitic acid, and oleic acid, determines its properties. Studies have indicated the existence of at least six polymorphic forms of cocoa butter, each possessing distinct characteristics and melting points. Recently, cocoa butter has garnered attention for its potential as a delivery system for pharmaceutical products. This review thoroughly explores cocoa butter, encompassing its production process, composition, properties, and polymorphism. It delves into its diverse applications across various industries including food, cosmetics, and pharmaceuticals. Additionally, the review investigates cocoa butter alternatives aiming to substitute cocoa butter and their roles in different drug delivery systems. The unique properties of cocoa butter have sparked interest in pharmaceutical industries, particularly since its introduction as a drug delivery system and excipient. This has prompted researchers and industry stakeholders to explore novel formulations and delivery methods, thereby expanding the range of options available to consumers in the pharmaceutical market.
Citation: Planta Med ; : -
PubDate: 2024-07-23T15:55:03+01:00
DOI: 10.1055/a-2359-8097
- Fuʼcupping Physical Permeation-Enhancing Technique Enhances the
Therapeutic Efficacy of Corydalis yanhusuo Gel Plaster-
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Authors: Cao; Guoqiong, Zhu, Zilan, Yang, Dingyi, Wu, Wenyu, Yang, Fangfang, Liu, Yao, Xu, Jian, Zhang, Yongping
Abstract: Corydalis yanhusuo, a traditional Chinese medicine, is widely used to treat various pains, and its active ingredients are alkaloids. This study aimed to develop a new type of transdermal gel plaster containing the extract of C. yanhusuo. Studies have shown that Fuʼcupping physical permeation-enhancing technique can promote the penetration of alkaloids and improve the efficacy of drugs. A transdermal gel plaster containing the extract of C. yanhusuo was prepared and optimized using an orthogonal experimental design. The skin permeation ability of the gel plaster was studied in vitro, while the anti-inflammatory and analgesic effects of the prepared patch alone or with Fuʼcupping physical permeation-enhancing technique were evaluated in a rat model. The formulation of a gel plaster containing C. yanhusuo extract was successfully prepared with an optimized composition consisting of glycerin (15 g), sodium polyacrylate (2 g), silicon dioxide (0.3 g), ethanol (2 g), aluminum oxide (0.1 g), citric acid (0.05 g), the C. yanhusuo extract (3 g), and water (15 g). The cumulative transdermal permeation of dehydrocorydaline, corypalmine, tetrahydropalmatine, and corydaline in 24 h was estimated to be 569.7 ± 63.2, 74.5 ± 13.7, 82.4 ± 17.2, and 38.9 ± 8.1 µg/cm2, respectively. The in vitro diffusion of dehydrocorydaline and corydaline followed the zero-order kinetics profile, while that of corypalmine and tetrahydropalmatine followed a Higuchi equation. The prepared gel plaster significantly reduced paw swelling, downregulated inflammatory cytokines, and mitigated pain induced by mechanical or chemical stimuli. The Fuʼcupping physical permeation-enhancing technique further improved the anti-inflammatory and analgesic effects of the patch. The combined application of the Fuʼcupping physical permeation-enhancing technique and the alkaloid gel plaster may be effective against inflammation and pain.
Citation: Planta Med ; : -
PubDate: 2024-07-19T09:42:12+01:00
DOI: 10.1055/a-2344-8841
- The Clinical Research on Ginger (Zingiber officinale): Insights from
ClinicalTrials.gov analysis-
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Authors: Matin; Maima, Matin, Farhan Bin, Ksepka, Natalia, Wysocki, Kamil, Mickael, Michel-Edwar, Wieczorek, Marek, Horbańczuk, Jarosław Olav, Jóźwik, Artur, Atanasov, Atanas G.
Abstract: Ginger (Zingiber officinale) has a rich history of traditional medicinal use and has attracted a global interest in its health benefits. This study aims to provide insights into the clinical research landscape on ginger, focusing on its pharmacological effects and studied health-related outcomes. The study design involves systematic analysis of data from clinical trials available on ClinicalTrials.gov and discussion of findings in the context of the existing scientific knowledge. A comprehensive analysis of clinical trials registered on ClinicalTrials.gov related to ginger was first conducted, and the scientific background related to specific ginger clinical research avenues was further evaluated through PubMed searches. A variety of trial designs were identified, including treatment, prevention, and supportive care objectives. A total of 188 studies were identified on ClinicalTrials.gov, of which 89 met the inclusion criteria. Among the 89 trials, treatment objectives were predominant (47.2%), and dietary supplements (40.4%) and drugs (27%) were the most prevalent intervention types. These trials covered various health outcomes, such as antiemetic activity, analgesic function, effects on health-related quality of life, blood pressure variation, energy expenditure, and reduction in xerostomia. This study analysis provides a comprehensive overview of the clinical trials landscape on ginger, focusing on its broad spectrum of potential health benefits. While individual trials show promising results, a significant gap in the available data with a low reporting rate of final results is identified, underscoring the need for further research to establish conclusive evidence of gingerʼs therapeutic potentials.
Citation: Planta Med ; : -
PubDate: 2024-07-19T09:42:10+01:00
DOI: 10.1055/a-2357-7064
- 5(S)-5-Carboxystrictosidine from the Root of Mappianthus iodoides
Ameliorates H2O2-induced Apoptosis in H9c2 Cardiomyocytes via PI3K/AKT and
ERK Pathways-
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Authors: Han; Ying, Xi, Junli, Zhang, Puzhao, Gong, Ming, Luo, Tao, Shao, Feng, Li, Yongxin, Zhong, Lingyun, Quan, Hexiu
Abstract: 5(S)-5-carboxystrictosidine (5-CS) is a compound found in the root of Mappianthus iodoides, a traditional Chinese medicine used for the treatment of coronary artery disease. The aim of the present study was to investigate the protective effect of 5-CS against oxidative stress-induced apoptosis in H9c2 cardiomyocytes and the underlying mechanisms. 5-CS pretreatment significantly protected against H2O2-induced cell death, LDH leakage, and malondialdehyde (MDA) production, which are indicators for oxidative stress injury. 5-CS also enhanced the activity of SOD and CAT. In addition, 5-CS pretreatment significantly inhibited H2O2-induced apoptosis, as determined by flow cytometer, suppressed the activity of caspase-3 and caspase-9, and attenuated the activation of cleaved caspase-3 and caspase-9. 5-CS also increased Akt and ERK activation altered by H2O2 using Western blot analysis. The PI3K-specific inhibitor LY294002 abolished 5-CS-induced Akt activation. The ERK-specific inhibitor PD98059 abolished 5-CS-induced ERK activation. Both LY294002 and PD98059 attenuated the protective effect of 5-CS on H9c2 cardiomyocytes against H2O2-induced apoptosis and cell death. Taken together, these results demonstrate that 5-CS prevents H2O2-induced oxidative stress injury in H9c2 cells by enhancing the activity of the endogenous antioxidant enzymes, inhibiting apoptosis, and modulating PI3K/Akt and ERK signaling pathways.
Citation: Planta Med ; : -
PubDate: 2024-07-19T09:42:08+01:00
DOI: 10.1055/a-2341-6175
- An In Silico-Guided Approach for Assessing Herb-Drug Interaction
Potential: A Case Study with Cudrania tricuspidata Leaf Extracts-
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Authors: Seo; Jeong In, Kwak, Young Beom, Cho, Seong Eun, Yoo, Hye Hyun
Pages: Abstract: Cudrania tricuspidata leaf extracts have long been utilized as traditional oriental medicines across Asian countries like Korea, China, and Japan. These extracts are renowned for their therapeutic benefits in addressing inflammation, tumors, obesity, and diabetes, maintaining their status as a pivotal folk remedy. Given the rising trend of combining medicinal herbs with conventional medications, it is imperative to explore the potential herb-drug interactions. However, there is a dearth of research on evaluating the herb-drug interactions of C. tricuspidata leaf extracts. Also, the intricate chemical composition of medicinal herbs presents methodological hurdles in establishing causal relationships between their constituents and herb-drug interactions. To overcome these challenges, a combined in silico and in vitro workflow was developed and effectively applied to evaluate the potential herb-drug interaction of C. tricuspidata leaf extracts along with the associated chemical factors. In in vitro CYP inhibition assays, C. tricuspidata leaf extracts exhibited potent inhibition of CYP1A2 and CYP2C8, with quercetin, kaempferol, and their glycosides identified as the major constituents. In silico analysis based on the prediction tools (ADMETlab 2.0 and pkCSM) identified key contributors to CYP inhibition, quercetin and kaempferol. Additionally, molecular docking analysis validated the binding of ligands (quercetin and kaempferol) to proteins (CYP1A2 and CYP2C8). These findings suggest that C. tricuspidata leaf extracts could inhibit CYP1A2 and CYP2C8, aiding in understanding the herb-drug interaction potential of C. tricuspidata leaf extracts for safe clinical application. Furthermore, this approach can be broadly applied to study herb-drug interactions of various medicinal herbs, enhancing their therapeutic benefits and reducing adverse reactions by considering chemical profiles relevant to herb-drug interaction potential in herbal preparations.
Citation: Planta Med ; : -
PubDate: 2024-08-06T15:43:57+01:00
DOI: 10.1055/a-2363-5033
Issue No: Vol.
eFirst
- Two Olea europaea L. Extracts Reduce Harmful Effects in a Model of
Neurotoxicity: Involvement of the Endoplasmic Reticulum-
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Authors: Maiuolo; Jessica, Bonacci, Sonia, Bosco, Francesca, Guarnieri, Lorenza, Ruga, Stefano, Leo, Antonio, Citraro, Rita, Ragusa, Salvatore, Palma, Ernesto, Mollace, Vincenzo, De Sarro, Giovambattista
Pages: Abstract: Prolonged exposure to lead has been recognized as harmful to human health as it may cause neurotoxic effects including mitochondrial damage, apoptosis, excitotoxicity, and myelin formation alterations, among others. Numerous data have shown that consuming olive oil and its valuable components could reduce neurotoxicity and degenerative conditions. Olive oil is traditionally obtained from olive trees; this plant (Olea europaea L.) is an evergreen fruit tree.In this manuscript, two extracts have been used and compared: the extract from the leaves of Olea europaea L. (OE) and the extract derived from OE but with a further sonication process (s-OE). Therefore, the objectives of this experimental work were as follows: 1) to generate an innovative extract; 2) to test both extracts on a model of neurotoxicity of human neurons induced following lead exposure; and 3) to study the mechanisms behind lead-induced neurotoxicity.The results showed that the mechanism involved in the neurotoxicity of lead included dysfunction of the cellular endoplasmic reticulum, which suffered oxidative damage. In addition, in all experiments, s-OE was more effective than OE, having greater and better effects against lead-induced damage and being dissolved in a smaller amount of EtOH, which promotes its sustainability.
Citation: Planta Med ; : -
PubDate: 2024-08-06T15:43:54+01:00
DOI: 10.1055/a-2353-1469
Issue No: Vol.
eFirst
- Correction: Purification, Molecular Docking and Cytotoxicity Evaluation of
Bioactive Pentacyclic Polyhydroxylated Triterpenoids from Salvia urmiensis
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Planta Med
DOI: 10.1055/a-2299-7492
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
Artikel in Thieme eJournals:
Inhaltsverzeichnis Volltext
Planta Med ; : -2024-04-15T13:39:46+01:00
Issue No: Vol.
eFirst
- Correction: The Potential of Berberine to Target Telocytes in Rabbit Heart
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Planta Med
DOI: 10.1055/a-2198-5523
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
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Planta Med ; : -2023-11-06T09:02:52+0100
Issue No: Vol.
eFirst
- Correction: Placental Passage of Humulone and Protopine in an Ex Vivo
Human Perfusion System-
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Planta Med
DOI: 10.1055/a-1666-5352
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
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Inhaltsverzeichnis open access Volltext
Planta Med ; : -2021-10-12T00:00:00+01:00
Issue No: Vol.
eFirst
- Correction: Natural Products as a Source of Inspiration for Novel
Inhibitors of Advanced Glycation Endproducts (AGEs) Formation-
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Planta Med
DOI: 10.1055/a-1585-5219
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
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Planta Med ; : -2021-08-24T00:00:00+01:00
Issue No: Vol.
eFirst
- Correction: A Novel Peptide Derived from Ginger Induces Apoptosis through
the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines-
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Planta Med
DOI: 10.1055/a-1468-1106
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
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Planta Med ; : -2021-03-30T00:00:00+01:00
Issue No: Vol.
eFirst
- Correction: Erianthridin Induces Non-small Cell Lung Cancer Cell Apoptosis
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Planta Med
DOI: 10.1055/a-1405-4720
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
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Planta Med ; : -2021-03-11T00:00:00+0100
Issue No: Vol.
eFirst
- Correction: Compound Cocktail Inhibits Influenza Viral Pneumonia via
Phospholipase Cγ1 Phosphorylation-Related Necroptosis and Partial
Autophagy in Natural Killer Cells-
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Planta Med
DOI: 10.1055/a-1388-0028
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
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Planta Med ; : -2021-02-11T00:00:00+0100
Issue No: Vol.
eFirst
- Correction: Pharmacokinetic Properties of Moracin C in Mice
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Planta Med
DOI: 10.1055/a-1384-8484
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
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Planta Med ; : -2021-02-05T00:00:00+0100
Issue No: Vol.
eFirst
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