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- Biological Effects of Cannabidiol on Human Cancer Cells: Systematic Review
of the Literature-
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Abstract: Publication date: Available online 25 May 2022Source: Pharmacological ResearchAuthor(s): Chiara Valenti, Monia Billi, Gian Luca Pancrazi, Elena Calabria, Niccolò Giuseppe Armogida, Gregorio Tortora, Stefano Pagano, Paolo Barnaba, Lorella Marinucci
- Demethylzeylasteral targets lactate by inhibiting histone lactylation to
suppress the tumorigenicity of liver cancer stem cells-
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Abstract: Publication date: Available online 21 May 2022Source: Pharmacological ResearchAuthor(s): Lianhong Pan, Fan Feng, Jiaqin Wu, Shibing Fan, Juanjuan Han, Shunxi Wang, Li Yang, Wanqian Liu, Chunli Wang, Kang Xu
- A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating
mφ polarization in TME-
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Abstract: Publication date: Available online 20 May 2022Source: Pharmacological ResearchAuthor(s): Xuejun Xiao, Yan Peng, Zheyue Wang, Louqian Zhang, Tingting Yang, Yangyang Sun, Yufeng Chen, Wenqing Zhang, Xinxia Chang, Wen Huang, Shuning Tian, Zhenqing Feng, Nabi Xinhua, Qi Tang, Yuan Mao
- Estimating the effectiveness of remdesivir on risk of COVID-19 mortality:
the role of observational data-
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Abstract: Publication date: Available online 20 May 2022Source: Pharmacological ResearchAuthor(s): Andrea Giacomelli, Alessandro Cozzi-Lepri, Giacomo Casalini, Letizia Oreni, Anna Lisa Ridolfo, Spinello Antinori
- TRPC1 Contributes to Endotoxemia-induced Myocardial Dysfunction via
Mediating Myocardial Apoptosis and Autophagy-
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Abstract: Publication date: Available online 19 May 2022Source: Pharmacological ResearchAuthor(s): Wen Tian, Shao-Yuan Liu, Meng Zhang, Jing-Ru Meng, Na Tang, Ying-Da Feng, Yang Sun, Yuan-Yuan Gao, Lei Zhou, Wei Cao, Xiao-Qiang Li
- Biomimetic Micelles to Accurately Regulate the Inflammatory
Microenvironment for Glomerulonephritis Treatment-
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Abstract: Publication date: Available online 18 May 2022Source: Pharmacological ResearchAuthor(s): Huijuan Zhang, Qingqing He, Jingjing Wang, Yaping Wang, Xiangyang Xuan, Mingli Sui, Zhenzhong Zhang, Lin Hou
- Overcoming Immunotherapeutic Resistance in PDAC: SIRPα-CD47 blockade
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Abstract: Publication date: Available online 18 May 2022Source: Pharmacological ResearchAuthor(s): Abdullahi Alausa, Khadijat Ayodeji Lawal, Oluwakemi Arinola Babatunde, E.N.O Obiwulu, Olajumoke Christianah Oladokun, Olumide Samuel Fadahunsi, Ugwu Obiora Celestine, Emmanuel Ugbede Moses, Akaniro Ifunanya Rejoice, Peter Ifeoluwa Adegbola
- The effects of sodium-glucose cotransporter 2 inhibitors on hepatocellular
carcinoma: From molecular mechanisms to potential clinical implications-
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Abstract: Publication date: Available online 16 May 2022Source: Pharmacological ResearchAuthor(s): Konstantinos Arvanitakis, Theocharis Koufakis, Kalliopi Kotsa, Georgios Germanidis
- Cannabis induced psychosis: a systematic review on the role of genetic
polymorphisms-
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Abstract: Publication date: Available online 16 May 2022Source: Pharmacological ResearchAuthor(s): Cláudia Carvalho, Maria A. Vieira-Coelho
- Natural HSP90 inhibitors as a potential therapeutic intervention in
treating cancers: A comprehensive review-
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Abstract: Publication date: Available online 13 May 2022Source: Pharmacological ResearchAuthor(s): Hui Yi Liew, Xin Yoong Tan, Hong Hao Chan, Kooi Yeong Khaw, Yong Sze Ong
- Anti-tumor Effects of Skp2 Inhibitor AAA-237 on NSCLC by Arresting Cell
Cycle at G0/G1 Phase and Inducing Senescence-
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Abstract: Publication date: Available online 13 May 2022Source: Pharmacological ResearchAuthor(s): Jinyi Liu, Xiangjin Zheng, Wan Li, Liwen Ren, Sha Li, Yihui Yang, Hong Yang, Binbin Ge, Guanhua Du, Jianyou Shi, Jinhua Wang
- Targeting adipokines: A new strategy for the treatment of myocardial
fibrosis-
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Abstract: Publication date: Available online 13 May 2022Source: Pharmacological ResearchAuthor(s): Xiaoying Han, Yi Zhang, Xinyu Zhang, Haixia Ji, Wenzhe Wang, Ou Qiao, Xia Li, Juan Wang, Changxiao Liu, Luqi Huang, Wenyuan Gao
- Biochanin A as a modulator of the inflammatory response: an updated
overview and therapeutic potential-
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Abstract: Publication date: Available online 10 May 2022Source: Pharmacological ResearchAuthor(s): Franciel Batista Felix, Juliana Priscila Vago, Vinícius Amorim Beltrami, Jessica Maria Dantas Araújo, Renata Grespan, Mauro Martins Teixeira, Vanessa Pinho
- A vitamin E long-chain metabolite and the inspired drug candidate
α-amplexichromanol relieve asthma features in an experimental model of
allergen sensitization-
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Abstract: Publication date: Available online 10 May 2022Source: Pharmacological ResearchAuthor(s): Ida Cerqua, Konstantin Neukirch, Michela Terlizzi, Elisabetta Granato, Elisabetta Caiazzo, Carla Cicala, Armando Ialenti, Raffaele Capasso, Oliver Werz, Rosalinda Sorrentino, Denis Seraphin, Jean-Jacques Helesbeux, Giuseppe Cirino, Andreas Koeberle, Fiorentina Roviezzo, Antonietta Rossi
- Epigenetic regulation of the DNMT1/MT1G/KLF4/CA9 axis synergizes the
anticancer effects of sorafenib in hepatocellular carcinoma-
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Abstract: Publication date: Available online 9 May 2022Source: Pharmacological ResearchAuthor(s): Tianzi Wei, Risheng Lin, Xing Fu, Yi Lu, Weiwen Zhang, Zhengxuan Li, Jian Zhang, Hao Wang
- Functional metabolomics revealed functional metabolic-characteristics of
chronic hepatitis that is significantly differentiated from acute
hepatitis in mice-
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Abstract: Publication date: Available online 7 May 2022Source: Pharmacological ResearchAuthor(s): Tianyu Wang, Longlong Hu, Jiongjiong Lu, Mengqing Xiao, Jinging Liu, Huiyu Xia, Haitao Lu
- An Overview of CDK3 in Cancer: Clinical Significance and Pharmacological
Implications-
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Abstract: Publication date: Available online 6 May 2022Source: Pharmacological ResearchAuthor(s): Theodosia Teo, Sara Kasirzadeh, Hugo Albrecht, Matthew J. Sykes, Yuchao Yang, Shudong Wang
- A multi-parameter approach to measurement of spontaneous myogenic
contractions in human stomach: Utilization to assess potential modulators
of myogenic contractions-
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Abstract: Publication date: Available online 6 May 2022Source: Pharmacological ResearchAuthor(s): Marilisa Straface, Marie-Ange Koussai, Raj Makwana, Ellie Crawley, Alexandra Palmer, Weigang Cai, Armen Gharibans, Miriam Adebibe, John Loy, Greg O’Grady, Paul LR Andrews, Gareth J Sanger
- In silico and in vitro structure-stability-function relationship of analog
peptides of Stigmurin and its antibacterial and antibiofilm activities-
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Abstract: Publication date: Available online 5 May 2022Source: Pharmacological ResearchAuthor(s): Allanny Alves Furtado, Alessandra Daniele-Silva, Igor Rafael Resende de Oliveira, Raudiney Frankilin Vasconcelos Mendes, Elizabeth Cristina Gomes dos Santos, Enéas de Carvalho, Igor Zumba Damasceno, Adriana Marina e Silva Parente, Kêsia Xisto da Fonseca Ribeiro de Sena, Arnóbio Antônio da Silva-Júnior, Rafael Matos Ximenes, Davi Serradella Vieira, Matheus de Freitas Fernandes-Pedrosa
- The impact of SGLT2 inhibition on imaging markers of cardiac function: A
systematic review and meta-analysis-
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Abstract: Publication date: Available online 4 May 2022Source: Pharmacological ResearchAuthor(s): Panagiotis Theofilis, Alexios S Antonopoulos, Themistoklis Katsimichas, Evangelos Oikonomou, Gerasimos Siasos, Constantina Aggeli, Konstantinos Tsioufis, Dimitris Tousoulis
- Ginkgolide B Targets and Inhibits Creatine Kinase B to Regulate the
CCT/TRiC-SK1 Axis and Exerts Pro-Angiogenic Activity in Middle Cerebral
Artery Occlusion Mice-
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Abstract: Publication date: Available online 2 May 2022Source: Pharmacological ResearchAuthor(s): Jiale Zhu, Zhiwei Jin, Lei Yang, Caili Zhao, Jianping Hu, Jinhu Chen, Yubao Han, Pei Yu, Jun Luo, Lingyi Kong, Chao Zhang
- Checkpoints and Immunity in Cancers: Role of GNG12
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Abstract: Publication date: Available online 2 May 2022Source: Pharmacological ResearchAuthor(s): Abdullahi Alausa, Ugwu Chukwuebuka Victor, Olumide Samuel Fadahunsi, Nurudeen Owolabi, Adeolu Adeniji, Mercy Olatinwo, Abdeen Tunde Ogunlana, Barakat Olaleke, Toheeb Adewale Balogun, Sunday Ogundepo, Peter Ifeoluwa Adegboola
- Theranostic nanosystem with supramolecular self-assembly for enhanced
reactive oxygen species-mediated apoptosis guided by dual-modality tumor
imaging-
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Abstract: Publication date: Available online 2 May 2022Source: Pharmacological ResearchAuthor(s): Dan Yan, Haili Zhang, Xiao Xu, Chunling Ren, Chao Han, Zhongrui Li
- Immunity and Inflammation in Pulmonary Arterial Hypertension: From
Pathophysiology Mechanisms to Treatment Perspective-
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Abstract: Publication date: Available online 30 April 2022Source: Pharmacological ResearchAuthor(s): Ran-ran Wang, Tian-yi Yuan, Jian-mei Wang, Yu-cai Chen, Jiu-liang Zhao, Meng-tao Li, Lian-hua Fang, Guan-hua Du
- DOC2B is a Negative Regulator of Wnt/β-catenin Signaling Pathway in
Cervical Cancer-
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Abstract: Publication date: Available online 30 April 2022Source: Pharmacological ResearchAuthor(s): Divya Adiga, Samatha Bhat, Sanjiban Chakrabarty, Shama Prasada Kabekkodu
- Revisiting The Concept of Incretin and Enteroendocrine L-cells as Type 2
Diabetes Mellitus Treatment-
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Abstract: Publication date: Available online 26 April 2022Source: Pharmacological ResearchAuthor(s): Kok-Hou Lok, Nicholas J Wareham, Rajesh Sreedharan Nair, Chee Wun How, Lay-Hong Chuah
- Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviated ischemic
stroke reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT
pathways-
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Abstract: Publication date: Available online 25 April 2022Source: Pharmacological ResearchAuthor(s): Jiale Cai, Jiayin Liang, Yutong Zhang, Lin Shen, Huiting Lin, Tao Hu, Sikai Zhan, Meixia Xie, Shengwang Liang, Minghua Xian, Shumei Wang
- Perivascular Adipose Tissue Modulates the Effects of Flavonoids on Rat
Aorta Rings: Role of Superoxide Anion and β3 Receptors-
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Abstract: Publication date: Available online 21 April 2022Source: Pharmacological ResearchAuthor(s): Ahmed Amer, Fusi Fabio, M. Valoti
- Mitochondrial stroke-like episodes: the search for new therapies
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Abstract: Publication date: Available online 21 April 2022Source: Pharmacological ResearchAuthor(s): Daniele Orsucci, Elena Caldarazzo Ienco, Vincenzo Montano, Gabriele Siciliano, Michelangelo Mancuso
- Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an
APP/PS1 double-transgenic mouse model of Alzheimer’s disease-
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Abstract: Publication date: Available online 20 April 2022Source: Pharmacological ResearchAuthor(s): Peipei Gao, Zhen Wang, Mengyao Lei, Jiaxing Che, Shuangxi Zhang, Tiantian Zhang, Yachong Hu, Le Shi, Li Cui, Jiankang Liu, Mami Noda, Yunhua Peng, Jiangang Long
- Deep Learning Applications for the accurate identification of
low-transcriptional activity drugs and their mechanism of actions-
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Abstract: Publication date: Available online 20 April 2022Source: Pharmacological ResearchAuthor(s): Shengqiao Gao, Lu Han, Dan Luo, Zhiyong Xiao, Gang Liu, Yongxiang Zhang, Wenxia Zhou
- Corrigendum to “Future directions for the discovery of natural
product-derived immunomodulating drugs: An IUPHAR positional review”
[Pharmacol. Res. 177 (2022) 106076]-
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Abstract: Publication date: Available online 12 April 2022Source: Pharmacological ResearchAuthor(s): Cherry L. Wainwright, Mauro M. Teixeira, David L. Adelson, Eric J. Buenz, Bruno David, Keith B. Glaser, Yuka Harata-Lee, Melanie-Jayne R. Howes, Angelo A. Izzo, Pasquale Maffia, Alejandro M.S. Mayer, Claire Mazars, David J. Newman, Eimear Nic Lughadha, Adriano M.C. Pimenta, John A.A. Parra, Zhipeng Qu, Hanyuan Shen, Michael Spedding, Jean-Luc Wolfender
- 1,8-cineole Ameliorates Right Ventricle Dysfunction Associated With
Pulmonary Arterial Hypertension by Restoring Connexin 43 and Mitochondrial
Homeostasis-
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Abstract: Publication date: Available online 2 March 2022Source: Pharmacological ResearchAuthor(s): Jorge M. Alves-Silva, Mónica Zuzarte, Carla Marques, Sofia Viana, Inês Preguiça, Rui Baptista, Cátia Ferreira, Carlos Cavaleiro, Neuza Domingues, Vilma A. Sardão, Paulo J. Oliveira, Flávio Reis, Lígia Salgueiro, Henrique Girão
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