Subjects -> ENVIRONMENTAL STUDIES (Total: 913 journals)
    - ENVIRONMENTAL STUDIES (810 journals)
    - POLLUTION (31 journals)
    - TOXICOLOGY AND ENVIRONMENTAL SAFETY (54 journals)
    - WASTE MANAGEMENT (18 journals)

ENVIRONMENTAL STUDIES (810 journals)            First | 1 2 3 4 5     

Showing 401 - 378 of 378 Journals sorted alphabetically
International Journal of Environment and Pollution     Hybrid Journal   (Followers: 3)
International Journal of Environment and Sustainable Development     Hybrid Journal   (Followers: 17)
International Journal of Environment and Waste Management     Hybrid Journal   (Followers: 2)
International Journal of Environment, Workplace and Employment     Hybrid Journal   (Followers: 7)
International Journal of Environmental Engineering     Hybrid Journal   (Followers: 6)
International Journal of Environmental Health Engineering     Open Access   (Followers: 1)
International Journal of Environmental Health Research     Hybrid Journal   (Followers: 3)
International Journal of Environmental Policy and Decision Making     Hybrid Journal   (Followers: 3)
International Journal of Environmental Research     Hybrid Journal  
International Journal of Environmental Research and Public Health     Open Access   (Followers: 22)
International Journal of Environmental Science and Technology     Hybrid Journal   (Followers: 6)
International Journal of Environmental Studies     Hybrid Journal   (Followers: 5)
International Journal of Exergy     Hybrid Journal   (Followers: 2)
International Journal of Global Environmental Issues     Hybrid Journal   (Followers: 4)
International Journal of Global Sustainability     Open Access   (Followers: 2)
International Journal of Global Warming     Hybrid Journal  
International Journal of Greenhouse Gas Control     Partially Free   (Followers: 5)
International Journal of Hygiene and Environmental Health     Hybrid Journal   (Followers: 7)
International Journal of Logistics Research and Applications : A Leading Journal of Supply Chain Management     Hybrid Journal   (Followers: 16)
International Journal of Mining and Geo-Engineering     Open Access  
International Journal of Phytoremediation     Hybrid Journal   (Followers: 1)
International Journal of Process Systems Engineering     Hybrid Journal   (Followers: 1)
International Journal of Recycling of Organic Waste in Agriculture     Open Access   (Followers: 1)
International Journal of Reliability and Safety     Hybrid Journal   (Followers: 11)
International Journal of Renewable Energy Development     Open Access   (Followers: 6)
International Journal of Social Sciences and Management     Open Access   (Followers: 2)
International Journal of Soil, Sediment and Water     Open Access   (Followers: 4)
International Journal of Stress Management     Full-text available via subscription   (Followers: 6)
International Journal of Sustainable Construction Engineering and Technology     Open Access   (Followers: 7)
International Journal of Sustainable Engineering     Hybrid Journal   (Followers: 4)
International Journal of Sustainable Materials and Structural Systems     Hybrid Journal   (Followers: 1)
International Journal of Sustainable Society     Hybrid Journal   (Followers: 2)
International Journal of the Commons     Open Access   (Followers: 2)
International Journal of Toxicology     Hybrid Journal   (Followers: 17)
International Journal of Water Resources and Environmental Engineering     Open Access   (Followers: 12)
International Review of Environmental and Resource Economics     Full-text available via subscription   (Followers: 4)
Iranian Journal of Health and Environment     Open Access  
ISLE: Interdisciplinary Studies in Literature and Environment     Hybrid Journal   (Followers: 3)
Isotopes in Environmental and Health Studies     Hybrid Journal  
JACEE (Journal of Advanced Civil and Environmental Engineering)     Open Access  
Jahangirnagar University Environmental Bulletin     Open Access  
Journal for the History of Environment and Society     Open Access   (Followers: 3)
Journal of Bioremediation & Biodegradation     Open Access   (Followers: 1)
Journal of Earth Science & Climatic Change     Open Access   (Followers: 14)
Journal of Petroleum & Environmental Biotechnology     Open Access   (Followers: 1)
Journal of Advances in Environmental Health Research     Open Access   (Followers: 2)
Journal Of Advances In Natural Sciences     Open Access   (Followers: 1)
Journal of Aging and Environment     Hybrid Journal   (Followers: 4)
Journal of Agricultural and Environmental Ethics     Hybrid Journal   (Followers: 8)
Journal of Agricultural Chemistry and Environment     Open Access   (Followers: 3)
Journal of Agriculture and Ecology Research International     Open Access  
Journal of Air Pollution and Health (رتبه علمی- پژوهشی)     Open Access  
Journal of Anatolian Environmental and Animal Sciences     Open Access  
Journal of Applied Ecology     Hybrid Journal   (Followers: 211)
Journal of Applied Meteorology and Climatology     Hybrid Journal   (Followers: 42)
Journal of Applied Sciences and Environmental Management     Open Access   (Followers: 1)
Journal of Applied Toxicology     Hybrid Journal   (Followers: 19)
Journal of Applied Volcanology     Open Access   (Followers: 7)
Journal of Applied Water Engineering and Research     Hybrid Journal  
Journal of Arid Environments     Hybrid Journal   (Followers: 12)
Journal of Biochemical and Molecular Toxicology     Hybrid Journal   (Followers: 4)
Journal of Biosystems Engineering     Full-text available via subscription  
Journal of Chemical Ecology     Hybrid Journal   (Followers: 4)
Journal of Civil Engineering and Environmental Sciences     Open Access  
Journal of Climate     Hybrid Journal   (Followers: 56)
Journal of Climate Change and Health     Open Access   (Followers: 6)
Journal of Coastal Research     Hybrid Journal   (Followers: 31)
Journal of Contaminant Hydrology     Hybrid Journal   (Followers: 19)
Journal of Earth, Environment and Health Sciences     Open Access   (Followers: 2)
Journal of East African Natural History     Full-text available via subscription   (Followers: 7)
Journal of Ecology     Hybrid Journal   (Followers: 142)
Journal of Ecology and Environment     Open Access   (Followers: 3)
Journal of Economic Development, Environment and People     Open Access   (Followers: 11)
Journal of Energy & Natural Resources Law     Hybrid Journal   (Followers: 5)
Journal of Energy and Environment Technology of Graduate School Siam Technology College     Open Access  
Journal of Environment and Earth Science     Open Access   (Followers: 11)
Journal of Environment and Ecology     Open Access   (Followers: 10)
Journal of Environment Pollution and Human Health     Open Access   (Followers: 3)
Journal of Environmental Analysis and Progress     Open Access  
Journal of Environmental and Agricultural Studies     Open Access   (Followers: 1)
Journal of Environmental and Public Health     Open Access   (Followers: 16)
Journal of Environmental Assessment Policy and Management     Hybrid Journal   (Followers: 5)
Journal of Environmental Chemical Engineering     Hybrid Journal   (Followers: 5)
Journal of Environmental Economics and Policy     Partially Free   (Followers: 4)
Journal of Environmental Education     Hybrid Journal   (Followers: 7)
Journal of Environmental Engineering and Landscape Management     Open Access   (Followers: 8)
Journal of Environmental Engineering and Science     Hybrid Journal   (Followers: 2)
Journal of Environmental Extension     Full-text available via subscription  
Journal of Environmental Geography     Open Access   (Followers: 6)
Journal of Environmental Law     Hybrid Journal   (Followers: 22)
Journal of Environmental Management     Hybrid Journal   (Followers: 44)
Journal of Environmental Management     Open Access   (Followers: 1)
Journal of Environmental Management and Tourism     Open Access   (Followers: 13)
Journal of Environmental Media     Hybrid Journal  
Journal of Environmental Planning and Management     Hybrid Journal   (Followers: 26)
Journal of Environmental Policy & Planning     Hybrid Journal   (Followers: 14)
Journal of Environmental Professionals Sri Lanka     Open Access  
Journal of Environmental Protection     Open Access   (Followers: 1)
Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances and Environmental Engineering     Hybrid Journal   (Followers: 5)
Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes     Hybrid Journal   (Followers: 5)
Journal of Environmental Science and Technology     Open Access   (Followers: 7)
Journal of Environmental Sciences     Full-text available via subscription   (Followers: 8)
Journal of Environmental Statistics     Open Access   (Followers: 4)
Journal of Environmental Studies and Sciences     Partially Free   (Followers: 2)
Journal of Environmental Sustainability     Open Access   (Followers: 7)
Journal of Environments     Open Access  
Journal of Exposure Science and Environmental Epidemiology     Hybrid Journal   (Followers: 6)
Journal of Fisheries and Environment     Open Access  
Journal of Forest and Natural Resource Management     Open Access  
Journal of Freshwater Ecology     Hybrid Journal   (Followers: 14)
Journal of Geography, Environment and Earth Science International     Open Access  
Journal of Geoscience and Environment Protection     Open Access  
Journal of Great Lakes Research     Hybrid Journal   (Followers: 5)
Journal of Green Building     Full-text available via subscription   (Followers: 10)
Journal of Hazardous Materials     Hybrid Journal   (Followers: 12)
Journal of Hazardous Materials Advances     Open Access  
Journal of Health Management     Hybrid Journal   (Followers: 10)
Journal of Health Organisation and Management     Hybrid Journal   (Followers: 29)
Journal of Housing and the Built Environment     Hybrid Journal   (Followers: 9)
Journal of Human Behavior in the Social Environment     Hybrid Journal   (Followers: 6)
Journal of Hydrology X     Open Access   (Followers: 5)
Journal of Industrial Ecology     Hybrid Journal   (Followers: 17)
Journal of Integrative Environmental Sciences     Hybrid Journal   (Followers: 4)
Journal of International Maritime Safety, Environmental Affairs, and Shipping     Open Access   (Followers: 1)
Journal of Iron and Steel Research International     Hybrid Journal   (Followers: 7)
Journal of Korean Society of Environmental Engineers     Open Access  
Journal of Land Use Science     Hybrid Journal   (Followers: 3)
Journal of Management and Sustainability     Open Access   (Followers: 7)
Journal of Mega Infrastructure & Sustainable Development     Hybrid Journal  
Journal of Natural Resources and Development     Open Access   (Followers: 2)
Journal of Natural Sciences Research     Open Access   (Followers: 1)
Journal of Occupational and Environmental Hygiene     Hybrid Journal   (Followers: 6)
Journal of Operational Oceanography     Hybrid Journal   (Followers: 5)
Journal of Organizational Behavior     Hybrid Journal   (Followers: 59)
Journal of Outdoor and Environmental Education     Hybrid Journal   (Followers: 2)
Journal of Pharmacological and Toxicological Methods     Hybrid Journal   (Followers: 7)
Journal of Plant Science and Phytopathology     Open Access  
Journal of Policy Analysis and Management     Hybrid Journal   (Followers: 28)
Journal of Population and Sustainability     Open Access  
Journal of Reliable Intelligent Environments     Hybrid Journal  
Journal of Renewable and Sustainable Energy     Hybrid Journal   (Followers: 11)
Journal of Research in Forestry, Wildlife and Environment     Open Access   (Followers: 5)
Journal of Rural and Community Development     Open Access   (Followers: 1)
Journal of Safety Engineering     Open Access   (Followers: 37)
Journal of Safety Research     Hybrid Journal   (Followers: 89)
Journal of School Violence     Hybrid Journal   (Followers: 6)
Journal of Sustainability and Environmental Management     Open Access   (Followers: 4)
Journal of Sustainable Development     Open Access   (Followers: 25)
Journal of Sustainable Development Studies     Open Access   (Followers: 15)
Journal of Sustainable Society     Open Access   (Followers: 2)
Journal of the American Planning Association     Hybrid Journal   (Followers: 18)
Journal of the Atmospheric Sciences     Hybrid Journal   (Followers: 83)
Journal of Tropical Ecology     Hybrid Journal   (Followers: 15)
Journal of Urban and Environmental Engineering     Open Access   (Followers: 5)
Journal of Urban Ecology     Open Access   (Followers: 5)
Journal of Vietnamese Environment     Open Access   (Followers: 1)
Journal of Water and Environmental Nanotechnology     Open Access   (Followers: 1)
Journal of Water Security     Open Access   (Followers: 6)
Julius-Kühn-Archiv     Open Access  
Jurnal Kesehatan Lingkungan     Open Access  
Jurnal Manusia dan Lingkungan     Open Access  
Jurnal Pengendalian Pencemaran Lingkungan     Open Access  
Jurnal Presipitasi     Open Access   (Followers: 1)
Jurnal Rekayasa Kimia & Lingkungan     Open Access  
Jurnal Sains & Teknologi Lingkungan     Open Access  
Jurnal Wilayah dan Lingkungan     Open Access  
Knowledge Management Research & Practice     Hybrid Journal   (Followers: 16)
Koedoe : African Protected Area Conservation and Science     Open Access   (Followers: 2)
Lake and Reservoir Management     Hybrid Journal   (Followers: 7)
Landscape Ecology     Hybrid Journal   (Followers: 61)
Landscapes     Hybrid Journal   (Followers: 18)
Latin American Journal of Management for Sustainable Development     Hybrid Journal  
Letras Verdes. Revista Latinoamericana de Estudios Socioambientales     Open Access  
Limnological Review     Open Access   (Followers: 3)
Living Reviews in Landscape Research     Open Access  
Local Environment: The International Journal of Justice and Sustainability     Hybrid Journal   (Followers: 8)
Low Carbon Economy     Open Access   (Followers: 4)
Luna Azul     Open Access  
M+A. Revista Electrónica de Medioambiente     Open Access  
Macquarie Journal of International and Comparative Environmental Law     Full-text available via subscription   (Followers: 7)
Madagascar Conservation & Development     Open Access   (Followers: 2)
Management International Review     Hybrid Journal   (Followers: 7)
Management of Environmental Quality: An International Journal     Hybrid Journal   (Followers: 2)
Management of Sustainable Development     Open Access   (Followers: 4)
Marine Ecology     Hybrid Journal   (Followers: 27)
Marine Ecology Progress Series MEPS     Hybrid Journal   (Followers: 34)
Marine Environmental Research     Hybrid Journal   (Followers: 31)
Marine Pollution Bulletin     Hybrid Journal   (Followers: 36)
Materials for Renewable and Sustainable Energy     Open Access   (Followers: 6)
Medio Ambiente y Urbanizacion     Full-text available via subscription  
Mediterranean Geoscience Reviews     Hybrid Journal  
Membranes     Open Access   (Followers: 3)
Metabarcoding and Metagenomics     Open Access  
Michigan Journal of Sustainability     Open Access   (Followers: 1)
Microbial Risk Analysis     Full-text available via subscription  
Microplastics and Nanoplastics     Open Access   (Followers: 1)
Mine Water and the Environment     Hybrid Journal   (Followers: 5)
Mitigation and Adaptation Strategies for Global Change     Open Access   (Followers: 8)
Modeling Earth Systems and Environment     Hybrid Journal   (Followers: 1)
Monteverdia     Open Access   (Followers: 1)

  First | 1 2 3 4 5     

Similar Journals
Journal Cover
International Journal of Toxicology
Journal Prestige (SJR): 0.449
Citation Impact (citeScore): 1
Number of Followers: 17  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1091-5818 - ISSN (Online) 1092-874X
Published by Sage Publications Homepage  [1174 journals]
  • Tumor-Inhibitory Effects of Zerumbone Against HT-29 Human Colorectal
           Cancer Cells

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      Authors: Fezzeh Memari, Farshad Mirzavi, Mohammad Jalili‐Nik, Amir R. Afshari, Ahmad Ghorbani, Mohammad Soukhtanloo
      Abstract: International Journal of Toxicology, Ahead of Print.
      Colorectal cancer (CRC) is the second cause of cancer-associated death globally. Recently, herbal medicinal products and, in particular, zerumbone have been widely studied and used for cancer treatment as they induce significant anti-cancer effects. However, there is limited information about the anti-cancer effects of zerumbone in CRC. Therefore, we aimed to investigate the in vitro anti-cancer effects of the zerumbone in CRC, focusing on cell apoptosis and migration. Anti-proliferative and anti-migratory effects of zerumbone on HT-29 cells were evaluated using MTT and scratch wound healing assay, respectively. Quantitative real-time PCR (qRT-PCR) was performed to determine the mRNA expression levels of migration and apoptosis-related genes. Apoptosis and cell cycle distribution were evaluated by flow cytometry. The intracellular level of reactive oxygen species (ROS) was measured using a ROS assay kit. Additionally, matrix metalloproteinase-2/-9 (MMP-2/-9) activity was determined using gelatin zymography. Zerumbone suppressed the viability of the HT-29 cells dose-dependently while having less cytotoxicity on normal NIH/3T3 cells. Zerumbone induced apoptosis in HT-29 cells and arrested the cell cycle in the G2/M phase. These effects were associated with alteration in the expression of apoptosis-related genes (up-regulation of Bax and down-regulation of Bcl-2 genes). Zerumbone also enhanced the generation of ROS in HT-29 cells. Furthermore, zerumbone significantly inhibited the migration of HT-29 cells and decreased MMP-2/-9 mRNA expression and activity. Our findings provide a potential use for zerumbone to induce apoptosis and suppress metastasis in HT-29 cells; thus, it could be developed as a promising natural agent for future CRC therapy.
      Citation: International Journal of Toxicology
      PubDate: 2022-06-20T03:17:09Z
      DOI: 10.1177/10915818221104417
       
  • Regulatory Experience Assessing the Carcinogenic Potential of a Monoclonal
           Antibody Inhibiting PCSK9, Bococizumab, Including a 2-Year Carcinogenicity
           Study in Rats

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      Authors: Bernard S. Buetow, Gregg D Cappon, Laura M. Aschenbrenner, Lawrence Updyke, Vince R. Torti, Mark Evans, Shana R. Dalton, Steven Bailey, Christopher J. Bowman
      Abstract: International Journal of Toxicology, Ahead of Print.
      Bococizumab is an anti-PCSK9 monoclonal antibody that was intended for the treatment of hypercholesterolemia. After reviewing the 6-month rat toxicity study data, in which there was a low spontaneous tumor incidence, unrelated to bococizumab administration, the U.S. FDA granted a carcinogenicity waiver request based on a weight-of-evidence assessment of low carcinogenic risk. Subsequently, after reviewing 6-month rat toxicity study data from another anti-PCSK9 antibody, RN317, with a similar low tumor incidence (unrelated to RN317), the U.S. FDA rescinded the bococizumab carcinogenicity study waiver and requested a full 2-year rat carcinogenicity study be conducted. The resulting 2-year carcinogenicity study demonstrated no bococizumab-related increase in tumors, confirming the weight-of-evidence evaluation and alleviating concerns regarding the carcinogenic potential. Here we report the scientific and regulatory background that led to the request for a rat carcinogenicity study, the feedback on the design of the carcinogenicity study, and the results from this study which affirmed the original weight-of-evidence assessment of low carcinogenic risk.
      Citation: International Journal of Toxicology
      PubDate: 2022-06-08T05:03:28Z
      DOI: 10.1177/10915818221106397
       
  • Safety Assessment of Skin and Connective Tissue-Derived Proteins and
           Peptides as Used in Cosmetics

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      Authors: Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 19 skin and connective tissue-derived proteins and peptides, which are reported to function mainly as skin and/or hair conditioning agents in cosmetics. The Panel reviewed the relevant data provided and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.
      Citation: International Journal of Toxicology
      PubDate: 2022-06-07T05:16:19Z
      DOI: 10.1177/10915818221104783
       
  • Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine
           on 11 Major Human Drug Metabolizing Cytochrome P450s

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      Authors: Sharoen Y. M. Lim, Jason Siau Ee Loo, Mustafa Alshagga, Mohammed A. Alshawsh, Chin E. Ong, Yan Pan
      Abstract: International Journal of Toxicology, Ahead of Print.
      Cathine is the stable form of cathinone, the major active compound found in khat (Catha edulis Forsk) plant. Khat was found to inhibit major phase I drug metabolizing cytochrome P450 (CYP) enzyme activities in vitro and in vivo. With the upsurge of khat consumption and the potential use of cathine to combat obesity, efforts should be channelled into understanding potential cathine-drug interactions, which have been rather limited. The present study aimed to assess CYPs activity and inhibition by cathine in a high-throughput in vitro fluorescence-based enzyme assay and molecular docking analysis to identify how cathine interacts within various CYPs’ active sites. The half maximal inhibitory concentration (IC50) values of cathine determined for CYP2A6 and CYP3A4 were 80 and 90 μM, while CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP2J2 and CYP3A5 showed no significant inhibition. Furthermore, in Ki analysis, the Lineweaver-Burk plots depicted non-competitive mixed inhibition of cathine on both CYP2A6 and CYP3A4 with Ki value of 63 and 100 μM, respectively. Cathine showed negligible time-dependent inhibition on CYPs. Further, molecular docking studies showed that cathine was bound to CYP2A6 via hydrophobic, hydrogen and π-stacking interactions and formed hydrophobic and hydrogen bonds with active site residues in CYP3A4. Both molecular docking prediction and in vitro outcome are in agreement, granting more detailed insights for predicting CYPs metabolism besides the possible cathine-drug interactions. Cathine-drug interactions may occur with concomitant consumption of khat or cathine-containing products with medications metabolized by CYP2A6 and CYP3A4.
      Citation: International Journal of Toxicology
      PubDate: 2022-06-04T10:06:10Z
      DOI: 10.1177/10915818221103790
       
  • Evaluation of Pharmaceuticals for DNA Damage in the Chicken Egg
           Genotoxicity Assay (CEGA)

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      Authors: Tetyana Kobets, Jian-Dong Duan, Esther Vock, Ulrich Deschl, Gary M. Williams
      Abstract: International Journal of Toxicology, Ahead of Print.
      DNA damage is an established initiating event in the mutagenicity and carcinogenicity of genotoxic chemicals. Accordingly, assessment of this endpoint is critical for chemicals which are being developed for use in humans. To assess the ability of the Chicken Egg Genotoxicity Assay (CEGA) to detect genotoxic pharmaceuticals, a set of 23 compounds with different pharmacological and reported genotoxic effects was tested for the potential to produce nuclear DNA adducts and strand breaks in the embryo-fetal livers using the 32P-nucleotide postlabeling (NPL) and comet assays, respectively. Due to high toxicity, two aneugens, colchicine and vinblastine, and an autophagy inhibitor, hydroxychloroquine, could not be evaluated. Out of the 20 remaining pharmaceuticals, 10 including estrogen modulators, diethylstilbestrol and tamoxifen, antineoplastics cyclophosphamide, etoposide, and mitomycin C, antifungal griseofulvin, local anesthetics lidocaine and prilocaine, and antihistamines diphenhydramine and doxylamine, yielded clear positive outcomes in at least one of the assays. The antihypertensive vasodilator hydralazine and antineoplastics streptozotocin and teniposide, produced only DNA strand breaks, which were not dose-dependent, and thus, the results with these 3 pharmaceuticals were considered equivocal. No DNA damage was detected for 7 compounds, including the purine antagonist 6-thioguanine, antipyretic analgesics acetaminophen and phenacetin, antibiotic ciprofloxacin, antilipidemic clofibrate, anti-inflammatory ibuprofen, and sedative phenobarbital. However, low solubility of these compounds limited dosages tested in CEGA. Overall, results in CEGA were largely in concordance with the outcomes in other systems in vitro and in vivo, indicating that CEGA provides reliable detection of DNA damaging activity of genotoxic compounds. Further evaluations with a broader set of compounds would support this conclusion.
      Citation: International Journal of Toxicology
      PubDate: 2022-06-04T07:53:24Z
      DOI: 10.1177/10915818221093583
       
  • Increasing the Reuse of Protein Non-Naïve Nonhuman Primates in
           Pharmaceutical Drug Discovery and Development: An Overview and Industry
           Position on the Challenges and Benefits

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      Authors: Charles Mattis, Natalie Bratcher, Monika Burns, Christopher Carosino, Christina de Zafra, R. Marcus Fancher, Katrin Georgi, Candace Graff, Renee R. Hukkanen, Colena Johnson, Yanbin Lao, Amber Lange, Donna Lee, Michelle Lepherd, Sean Maguire, Mantas Malisauskas, Melinda Manuel, Sonia Miranda, Lori Reed, Rosemary Santos, Brian Sayers, David Shaw, David Shuster
      Abstract: International Journal of Toxicology, Ahead of Print.
      The IQ Consortium NHP Reuse Working Group (WG) comprises members from 15 pharmaceutical and biotechnology companies. In 2020, the WG developed and distributed a detailed questionnaire on protein non-naïve NHP reuse to the WG member companies. The WG received responses from key stakeholders including principal investigators, facility managers, animal welfare officers and research scientists. This paper’s content reflects the consolidated opinion of the WG members and the questionnaire responses on the subject of NHP reuse within nonclinical programs at all stages of research and development. Many of the pharmaceutical companies represented in the working group or participating in the questionnaire have already achieved some level of NHP reuse in their nonclinical programs, but the survey results suggested that there is significant potential to increase NHP reuse further and a need to understand the considerations involved in reuse more clearly. The WG has also focused carefully on the inherent concerns and risks of implementing protein non-naive NHP reuse and has evaluated the best methods of risk assessment and decision-making. This paper presents a discussion on the challenges and opportunities surrounding protein non-naïve NHP reuse and aims to stimulate further industry dialogue on the subject and provide guidance for pharmaceutical companies to establish roadmaps and decision trees enabling increased protein non-naïve NHP reuse. In addition, this paper represents a solid basis for collaborative engagement between pharmaceutical and biotechnology companies with contract research organizations (CROs) to discuss how the availability of protein non-naïve NHP within CROs can be better leveraged for their use within nonclinical studies.
      Citation: International Journal of Toxicology
      PubDate: 2022-06-03T06:03:31Z
      DOI: 10.1177/10915818221101791
       
  • Shp2 in Alveolar Macrophages Regulates Macrophage I Phenotype in Acute
           Lung Injury

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      Authors: Dawei Wang, Qiumei Cao
      Abstract: International Journal of Toxicology, Ahead of Print.
      Macrophage play important role in acute lung injury (ALI). This study aims to explore the possible role of Shp2 in regulating macrophage 1 (M1) in ALI progression. ALI was induced in rats by intravenous injection of lipopolysacharide (LPS). Lentivirus was used to knock down Shp2 expression. Lungs from LPS-induced ALI rats were evaluated by H&E staining and wet/dry lung weight ratio (W/D ratio) measurement. The expression of inflammatory cytokines IL-1β, TNF-α and IL-6 in bronchoalveolar lavage fluid were detected by ELISA. The expressions of M1 biomarker (iNOS) and macrophage 2 (M2) biomarker (Arg-1) in lung tissues and macrophages were measured by immunofluorescence and western blot. The ratio of M2/M1 was detected by flow cytometry. Inflammatory cytokines were highly expressed in ALI rat models, in which elevated expression of iNOS and decreased Arg-1 expression were detected. Shp2 was found to be highly expressed in lung tissues of ALI rat models. LPS treatment in NR8383 cells lead to increased M1 phenotype and elevated expression of Shp2. Suppression on Shp2 expression can counteract the LPS-induced effect and further attenuate ALI progression. Evidence collected from ALI rat and cell models showed that suppression Shp2 expression in macrophages can inhibit M1 phenotype to attenuate ALI progression.
      Citation: International Journal of Toxicology
      PubDate: 2022-06-02T12:51:08Z
      DOI: 10.1177/10915818221105227
       
  • Book Review

    • Free pre-print version: Loading...

      Authors: Stephen J Newsholme
      Abstract: International Journal of Toxicology, Ahead of Print.

      Citation: International Journal of Toxicology
      PubDate: 2022-06-02T10:41:38Z
      DOI: 10.1177/10915818221106034
       
  • Repeated-Dose Toxicity, Biodistribution, and Shedding Assessments With a
           ChAd155 Respiratory Syncytial Virus Vaccine Candidate Evaluated in Rabbits
           and Rats

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      Authors: Alan H. Stokes, Camille Planty, Johanne Pion, Philippe Ancian, Alexandra Rogue, Carine Bansard, Jérémy Silvano, Dominique Papineau, Nawel Ben Abdeljelil, Giulietta Maruggi, Haifeng Song, Catherine Spickler, Karine Blouin, Guillaume Dubois, Luis-Alexander Rodriguez, Judith Baumeister, Ann-Muriel Steff, Eric Destexhe
      Abstract: International Journal of Toxicology, Ahead of Print.
      Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants, and toddlers and vaccines are not yet available. A pediatric RSV vaccine (ChAd155-RSV) is being developed to protect infants against RSV disease. The ChAd155-RSV vaccine consists of a recombinant replication-deficient chimpanzee-derived adenovirus (ChAd) group C vector engineered to express the RSV antigens F, N, and M2-1. The local and systemic effects of three bi-weekly intramuscular injections of the ChAd155-RSV vaccine was tested in a repeated-dose toxicity study in rabbits. After three intramuscular doses, the ChAd155-RSV vaccine was considered well-tolerated. Changes due to the vaccine-elicited inflammatory reaction/immune response were observed along with transient decreases in platelet count without physiological consequences, already reported for other adenovirus-based vaccines. In addition, the biodistribution and shedding of ChAd155-RSV were also characterized in two studies in rats. The distribution and persistence of the ChAd155-RSV vaccine candidate was consistent with other similar adenovector-based vaccines, with quantifiable levels of ChAd155-RSV observed at the injection site (muscle) and the draining lymph nodes up to 69 days post administration. The shedding results demonstrated that ChAd155-RSV was generally not detectable in any secretions or excreta samples. In conclusion, the ChAd155-RSV vaccine was well-tolerated locally and systemically.
      Citation: International Journal of Toxicology
      PubDate: 2022-06-02T03:14:29Z
      DOI: 10.1177/10915818221101788
       
  • Book Review

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      Authors: William J. Brock
      Abstract: International Journal of Toxicology, Ahead of Print.

      Citation: International Journal of Toxicology
      PubDate: 2022-06-01T03:30:29Z
      DOI: 10.1177/10915818221106032
       
  • Safety Assessment of Plant-Derived Proteins and Peptides as Used in
           Cosmetics

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      Authors: Christina L. Burnett, Ivan J. Boyer, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 19 plant-derived proteins and peptides, which function mainly as skin and/or hair conditioning agents in personal care products. The Panel concluded that 18 plant-derived proteins and peptides are safe as used in the present practices of use and concentration as described in this safety assessment, while the data on Hydrolyzed Maple Sycamore Protein are insufficient to determine safety.
      Citation: International Journal of Toxicology
      PubDate: 2022-05-23T11:58:23Z
      DOI: 10.1177/10915818221100700
       
  • Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting
           Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™

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      Authors: Jean G. Sathish, Siddhartha Bhatt, Jamie K. DaSilva, Declan Flynn, Stephen Jenkinson, Amit S. Kalgutkar, Maggie Liu, Balasubramanian Manickam, Jason Pinkstaff, William J. Reagan, Norimitsu Shirai, Ahmed M. Shoieb, Madhu Sirivelu, Saurabh Vispute, Allison Vitsky, Karen Walters, Todd A. Wisialowski, Lawrence W. Updyke
      Abstract: International Journal of Toxicology, Ahead of Print.
      COVID-19 is a potentially fatal infection caused by the SARS-CoV-2 virus. The SARS-CoV-2 3CL protease (Mpro) is a viral enzyme essential for replication and is the target for nirmatrelvir. Paxlovid (nirmatrelvir co-administered with the pharmacokinetic enhancer ritonavir) showed efficacy in COVID-19 patients at high risk of progressing to hospitalization and/or death. Nonclinical safety studies with nirmatrelvir are essential in informing benefit-risk of Paxlovid and were conducted to support clinical development. In vivo safety pharmacology assessments included a nervous system/pulmonary study in rats and a cardiovascular study in telemetered monkeys. Potential toxicities were assessed in repeat dose studies of up to 1 month in rats and monkeys. Nirmatrelvir administration (1,000 mg/kg, p.o.) to male rats produced transient increases in locomotor activity and respiratory rate but did not affect behavioral endpoints in the functional observational battery. Cardiovascular effects in monkeys were limited to transient increases in blood pressure and decreases in heart rate, observed only at the highest dose tested (75 mg/kg per dose b.i.d; p.o.). Nirmatrelvir did not prolong QTc-interval or induce arrhythmias. There were no adverse findings in repeat dose toxicity studies up to 1 month in rats (up to 1,000 mg/kg daily, p.o.) or monkeys (up to 600 mg/kg daily, p.o.). Nonadverse, reversible clinical pathology findings without clinical or microscopic correlates included prolonged coagulation times at ≥60 mg/kg in rats and increases in transaminases at 600 mg/kg in monkeys. The safety pharmacology and nonclinical toxicity profiles of nirmatrelvir support clinical development and use of Paxlovid for treatment of COVID-19.
      Citation: International Journal of Toxicology
      PubDate: 2022-05-21T08:14:51Z
      DOI: 10.1177/10915818221095489
       
  • Evaluation of Pulmonary Effects of 3-D Printer Emissions From
           Acrylonitrile Butadiene Styrene Using an Air-Liquid Interface Model of
           Primary Normal Human-Derived Bronchial Epithelial Cells

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      Authors: Mariana T. Farcas, Walter McKinney, Jayme Coyle, Marlene Orandle, W. Kyle Mandler, Aleksandr B. Stefaniak, Lauren Bowers, Lori Battelli, Diana Richardson, Mary A. Hammer, Sherri A. Friend, Samantha Service, Michael Kashon, Chaolong Qi, Duane R. Hammond, Treye A. Thomas, Joanna Matheson, Yong Qian
      Abstract: International Journal of Toxicology, Ahead of Print.
      This study investigated the inhalation toxicity of the emissions from 3-D printing with acrylonitrile butadiene styrene (ABS) filament using an air-liquid interface (ALI) in vitro model. Primary normal human-derived bronchial epithelial cells (NHBEs) were exposed to ABS filament emissions in an ALI for 4 hours. The mean and mode diameters of ABS emitted particles in the medium were 175 ± 24 and 153 ± 15 nm, respectively. The average particle deposition per surface area of the epithelium was 2.29 × 107 ± 1.47 × 107 particle/cm2, equivalent to an estimated average particle mass of 0.144 ± 0.042 μg/cm2. Results showed exposure of NHBEs to ABS emissions did not significantly affect epithelium integrity, ciliation, mucus production, nor induce cytotoxicity. At 24 hours after the exposure, significant increases in the pro-inflammatory markers IL-12p70, IL-13, IL-15, IFN-γ, TNF-α, IL-17A, VEGF, MCP-1, and MIP-1α were noted in the basolateral cell culture medium of ABS-exposed cells compared to non-exposed chamber control cells. Results obtained from this study correspond with those from our previous in vivo studies, indicating that the increase in inflammatory mediators occur without associated membrane damage. The combination of the exposure chamber and the ALI-based model is promising for assessing 3-D printer emission-induced toxicity.
      Citation: International Journal of Toxicology
      PubDate: 2022-05-19T06:19:50Z
      DOI: 10.1177/10915818221093605
       
  • Safety Assessment of Hydroxyethyl-3,4-Methylenedioxyaniline HCl as Used in
           Cosmetics

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      Authors: Laura N Scott, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Hydroxyethyl-3,4-Methylenedioxyaniline HCl, which is reported to function as a hair dye ingredient. The Panel reviewed relevant data provided in this safety assessment, and concluded that Hydroxyethyl-3,4-Methylenedioxyaniline HCl is safe for use as a hair dye ingredient in the present practices of use and concentrations described in this report. The Panel cautions that this ingredient should not be used in cosmetic products in which N-nitroso compounds can be formed.
      Citation: International Journal of Toxicology
      PubDate: 2022-05-16T07:47:43Z
      DOI: 10.1177/10915818221099897
       
  • Safety Assessment of Ethers and Esters of Ascorbic Acid as Used in
           Cosmetics

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      Authors: Wilbur Johnson, Ivan J. Boyer, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 7 ethers and esters of ascorbic acid, which collectively function as antioxidants, skin-conditioning agents, skin protectants, fragrance ingredients, and skin bleaching agents in cosmetic products. The Panel reviewed relevant data relating to the safety of these ingredients, and concluded that the ethers and esters of ascorbic acid are safe in the present practices of use and concentration, as described in this safety assessment.
      Citation: International Journal of Toxicology
      PubDate: 2022-05-13T09:00:50Z
      DOI: 10.1177/10915818221093545
       
  • Safety Assessment of L-β-Aminoisobutyric Acid (L-BAIBA): Subchronic
           Toxicity Study in Sprague Dawley Rats

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      Authors: Devanand Shanmugasundaram, Qiru Fan, Mingru Wang, Ronghua Yi, Ou Wang
      Abstract: International Journal of Toxicology, Ahead of Print.
      L-3-Aminoisobutyric acid (L-BAIBA) is an endogenous compound in human metabolism when thymine and valine undergo catabolism. L-BAIBA represents one of the two isomers of BAIBA in biological systems. BAIBA has been shown to reduce body fat percentage via an increase in fatty acid oxidation and a decrease in hepatic lipogenesis. However, no toxicological effects of L-BAIBA in animals or humans have been established. The present study was designed to evaluate the safety and toxic potentials of this compound, where L-BAIBA was administered orally to Sprague Dawley rats at 100, 300, and 900 mg/kg/day for 90 days. No treatment-related adverse effects were observed in any of the treatment groups. Based on the results, the No-Observed-Adverse-Effect Level (NOAEL) of L-BAIBA was 900 mg/kg/day.
      Citation: International Journal of Toxicology
      PubDate: 2022-05-13T08:15:51Z
      DOI: 10.1177/10915818221094487
       
  • Safety Assessment of Carbonate Salts as Used in Cosmetics

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      Authors: Wilbur Johnson, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 6 carbonate salts which function as absorbents, bulking agents, opacifying agents, pH adjusters, buffering agents, abrasives, and oral care agents in cosmetic products. The Panel reviewed relevant data relating to the safety of these ingredients, and concluded that these carbonate salts are safe in the present practices of use and concentration in cosmetics when formulated to be non-irritating.
      Citation: International Journal of Toxicology
      PubDate: 2022-05-09T04:46:04Z
      DOI: 10.1177/10915818221087202
       
  • Safety Assessment of Rosa canina-derived Ingredients as Used in Cosmetics

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      Authors: Wilbur Johnson, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 12 Rosa canina-derived ingredients, which are reported to function as skin conditioning agents, fragrance ingredients, cosmetic astringents, anti-acne agents, abrasives, humectants, and exfoliants in cosmetic products. Because final product formulations may contain multiple botanicals, each containing the same constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching cumulative levels that may be hazardous to consumers. The Panel reviewed relevant data relating to the safety of these ingredients and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating and non-sensitizing.
      Citation: International Journal of Toxicology
      PubDate: 2022-05-07T03:52:55Z
      DOI: 10.1177/10915818221080088
       
  • Safety Assessment of Bovine Milk Proteins and Protein Derivatives as Used
           in Cosmetics

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      Authors: Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 16 bovine milk proteins and protein-derived ingredients, which function mainly as skin and hair conditioning agents in personal care products. The Panel reviewed relevant data provided in this safety assessment, and concluded that these ingredients are safe in the present practices of use and concentration.
      Citation: International Journal of Toxicology
      PubDate: 2022-05-05T01:03:49Z
      DOI: 10.1177/10915818221098137
       
  • Safety Assessment of Hydrofluorocarbon 152a as Used in Cosmetics

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      Authors: Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Hydrofluorocarbon 152a, which functions as a propellant in personal care products. The Panel reviewed relevant data provided in this safety assessment, and concluded that Hydrofluorocarbon 152a is safe in the present practices of use and concentration described in this safety assessment.
      Citation: International Journal of Toxicology
      PubDate: 2022-04-19T08:46:56Z
      DOI: 10.1177/10915818221083516
       
  • Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used
           in Cosmetics

    • Free pre-print version: Loading...

      Authors: Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate, which functions as an oxidative hair dye ingredient. The Panel reviewed relevant data provided in this safety assessment, and concluded that 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate is safe in the present practices of use and concentration in oxidative hair dye formulations.
      Citation: International Journal of Toxicology
      PubDate: 2022-04-18T11:37:08Z
      DOI: 10.1177/10915818221082093
       
  • Amended Safety Assessment of Butyl Polyoxyalkylene Ethers as Used in
           Cosmetics

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      Authors: Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth
      Abstract: International Journal of Toxicology, Ahead of Print.
      The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 46 butyl polyoxyalkylene ethers that share a common structural motif, namely a butyl chain (4 carbon alkyl chain) bound to a polyoxyalkylene (PPG, PEG, or both); 23 of these ethers were previously reviewed by the Panel, and 23 are reviewed herein for the first time. Most of the butyl polyoxyalkylene ethers have several functions in cosmetics, but the most common reported functions include hair conditioning agent and skin conditioning agent, and many reportedly function as solvents. Upon review of new data, including frequency and concentration of use, and data from previous Panel reports and on read-across analogs, the Panel concluded that these ingredients are safe in the present practices of use and concentration in cosmetics when formulated to be non-irritating.
      Citation: International Journal of Toxicology
      PubDate: 2022-02-11T03:57:37Z
      DOI: 10.1177/10915818211059697
       
 
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