Abstract: The toxicity of the active pharmaceutical ingredient and nevirapine-based drug at analytical concentrations was evaluated under laboratory conditions, using Allium cepa seeds as a model. The germination index of the negative control was 86.8 ± 2.1. The concentrations of 6.42 and 9.54 mg/L of the active pharmaceutical ingredient and 11.20 mg/L of the nevirapine-based drug showed a statistically higher germination index than the negative control. We found that the root growth of the negative control was 1.7 ± 0.6 mm and that the root growth was statistically lower than the negative control at concentrations of 9.54 and 17.73 mg/L of active pharmaceutical ingredient and 5.48, 11.20, and 17.68 mg/L of the drug. The mitotic index of negative control and methyl methanesulfonate were 7.4 ± 2.7 and 12.8 ± 4.5, respectively. At a concentration of 17.68 mg/L of the nevirapine-based drug, the mitotic index of 12.7 ± 2.7 was statistically higher than the negative control and like the methyl methanesulfonate, which indicated that nevirapine was cytotoxic at this concentration. At all concentrations tested the chromosome abnormality indices were statistically higher than negative control, suggesting that nevirapine was genotoxic. The mutagenicity index of the negative control was 0.2 ± 0.3. At concentrations of 6.42, 9.54, and 17.73 mg/L of the active pharmaceutical ingredient and 17.68 mg/L of the nevirapine-based drug, the mutagenicity index was statistically higher than the negative control, indicating that nevirapine was mutagenic for A. cespa at these concentrations. The chromosomal adhesion was the most frequent chromosomal aberration in the groups exposed to nevirapine, suggesting that it has an aneugenic effect on the A. cepa species. PubDate: 23 May, 2023
Abstract: Due to the atmospheric pollution loads that started with the industrial revolution and have increased exponentially in the process that has come to the present day, the natural components of the atmosphere have been damaged and changed. One of the negative return points of this human-made degradation in the natural order is acid rain. Acid rains harm people directly and/or indirectly. One of the indirect effects is the negative effects on the food chain. Acid rains affect agricultural products, however, they affect the products from the soil. As a result, agricultural fields and agricultural products are damaged. The decreasing resources (water, etc.) with global warming and climate change also increase the negative impact on agricultural products. In this study, the negative effects of acid rain on agricultural areas were investigated and it was aimed to put forward the measures to reduce these negative effects. PubDate: 22 Feb, 2023
Abstract: The areas affected by mining operations are characterized by extremely complex environmental changes that affect all components of the natural complexes. In several cases, radical negative changes (transformations) take place, which cause the formation of the habitat, characterized by changes in characteristics of all components of the natural environment, including geological structure, soil cover, surface and groundwater and atmospheric air, respectively, flora and fauna. This generally leads to a sharp deterioration of ecological conditions, including living conditions of living organisms and human habitation, causing stressful situations, inconveniences, as well as characteristic diseases due to the influence of factors of excessive pollution of components of the natural environment. As one of the objects of the study, the impact zone of mining enterprises within the town of Sibai and its surroundings in the Republic of Bashkortostan was chosen. It is typical for the assessment of occurring changes and other industrial centers and districts located within the vast strip of the Southern Urals. It has been revealed that the greatest damage is inflicted on ecosystems of small rivers, which is caused by both direct and indirect entry of pollutants into them as a result of dissolution, leaching and entry from rock dumps, emissions into the atmosphere, and settling on the surface of soil and snow cover; direct discharge of wastewater into them, etc. It is shown that with the lingering impact of the regional response to global climate change, environmental problems are exacerbated. This calls for urgent measures to restore favorable environmental conditions and address a wide range of economic and social problems. PubDate: 19 Jan, 2023
Abstract: Economic impact is a stimulating effect on the economic condition of various regions. The paper describes the influence of the structure of the object on the choice of recreational activities, taking into account the sensitivity of the mountain structure to anthropogenic impact.Determined the value of the initial values of the applications of sociological research, which used to calculate the natural-territorial complexes - these are water bodies located on the territory with identified orographic structures, surrounded by forests, taking into account possible options for recreation.Evaluated of the assessment and comfort of the recreational area, based on the identification of psychophysiological characteristics, such as the sensation of noise, thermal effects of the environment. The development of recreation centers associated with the demand for recreationists, which also determined by the level of development and material base.Studies on the study of the Issyk-Kul region that the geographical characteristics of the territory (relief, water bodies, climate, etc.) have not only attractiveness, but inhibitory factors for rare types of recreational activities. PubDate: 18 Apr, 2023
Abstract: Laos ranked 8th in terms of total greenhouse gas emissions among ASEAN countries, with 17.9 million metric tons of carbon dioxide equivalent (MtCO2e) emissions. The energy sector was responsible for the majority of emissions, accounting for about 50% or 8.9 MtCO2e, followed by the agriculture sector at around 35% or 6.3 MtCO2e, and other sectors at approximately 15% or 2.7 MtCO2e (The Global Carbon Atlas reported, 2018). This study investigates greenhouse gas emissions and environmental issues among industrial entrepreneurs in Vientiane Capital, Lao PDR. Data was collected by using questionnaires and face-to-face interviews were conducted with participants from 80 different plants in Vientiane Capital between January 25 and March 20, 2018. It identifies various environmental problems caused by industrial plants, emphasizing the need for specific pollution source mitigation and sustainable waste management. The study reveals significant impacts on health and living conditions, highlighting the urgency for proactive measures. Climate variations, alterations in seasons, and intensified storms are identified as major contributors to violence levels. Strategies proposed by entrepreneurs include accurate measurement methods, pollution treatment systems, improved power efficiency, renewable energy adoption, an environmental protection organization, and efficiency enhancements in logistics and transportation. The study emphasizes the role of government, plant owners, and the general population in addressing CO2 emissions through collective efforts. Overall, it provides valuable insights and calls for proactive measures, stakeholder engagement, and diverse strategies for sustainability in Vientiane Capital and Laos. PubDate: 14 Jun, 2023
Abstract: The prospects of environmentally safe disinfection of urban sewerage using compositions of bactericidal complexes of copper with amino acids and iminodiacetate derivatives of mucopolysaccharides and triglycerides of fatty acids are shown. When they are dosed into wastewater, the complexes penetrate into the structure of Suspended Particulate Matter (SPM) and mucus and within a few minutes bind the structural fragments of pathogens and larvae, which leads to their death with the outflow of cell fluid, the disappearance of fecal odor, cessation of putrification and coagulation of SPM. The complete disinfection is achieved at doses of complexes of 0.8 - 1.5 mmol per 1 kg of dry matter. The composition is dosed into sewage wells. Organo-mineral masses settle from disinfected wastewater. The use of compositions will reduce the negative impact of sewerage on the sanitary-epidemiological and ecological situation in settlements, increase the efficiency of existing treatment facilities and produce organo-mineral masses as commercial products. PubDate: 14 Jan, 2023
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