Subjects -> ENVIRONMENTAL STUDIES (Total: 913 journals)
    - ENVIRONMENTAL STUDIES (810 journals)
    - POLLUTION (31 journals)
    - TOXICOLOGY AND ENVIRONMENTAL SAFETY (54 journals)
    - WASTE MANAGEMENT (18 journals)

ENVIRONMENTAL STUDIES (810 journals)            First | 1 2 3 4 5     

Showing 601 - 378 of 378 Journals sorted alphabetically
Research and Practice for Persons with Severe Disabilities     Full-text available via subscription   (Followers: 4)
Research Journal of Environmental Sciences     Open Access   (Followers: 2)
Research Journal of Environmental Toxicology     Open Access   (Followers: 2)
Resources     Open Access  
Resources and Environment     Open Access   (Followers: 2)
Resources, Conservation & Recycling     Hybrid Journal   (Followers: 21)
Resources, Conservation & Recycling : X     Open Access   (Followers: 1)
Resources, Conservation & Recycling Advances     Open Access   (Followers: 2)
Rethinking Ecology     Open Access  
Reuse/Recycle Newsletter     Hybrid Journal  
Review of Agricultural, Food and Environmental Studies     Hybrid Journal  
Review of Environmental Economics and Policy     Hybrid Journal   (Followers: 13)
Revista Brasileira de Ciências Ambientais     Open Access   (Followers: 3)
Revista Brasileira de Meio Ambiente     Open Access  
Revista de Ciencias Ambientales     Open Access  
Revista de Direito e Sustentabilidade     Open Access  
Revista de Gestão Ambiental e Sustentabilidade - GeAS     Open Access  
Revista de Salud Ambiental     Open Access  
Revista Eletrônica de Gestão e Tecnologias Ambientais     Open Access  
Revista Kawsaypacha: Sociedad y Medio Ambiente     Open Access  
Revista Laborativa     Open Access  
Revista Verde de Agroecologia e Desenvolvimento Sustentável     Open Access   (Followers: 4)
RUDN Journal of Ecology and Life Safety     Open Access  
Russian Journal of Ecology     Hybrid Journal   (Followers: 1)
Safety Science     Hybrid Journal   (Followers: 32)
SAR and QSAR in Environmental Research     Hybrid Journal   (Followers: 1)
Scandinavian Journal of Work, Environment & Health     Partially Free   (Followers: 14)
Science of The Total Environment     Hybrid Journal   (Followers: 45)
Smart Grid and Renewable Energy     Open Access   (Followers: 9)
Social and Environmental Accountability Journal     Hybrid Journal   (Followers: 3)
Soil and Sediment Contamination: An International Journal     Hybrid Journal   (Followers: 3)
Soil and Tillage Research     Hybrid Journal   (Followers: 10)
South Pacific Journal of Natural and Applied Sciences     Hybrid Journal  
Southern African Journal of Environmental Education     Open Access  
Southern Forests : a Journal of Forest Science     Hybrid Journal   (Followers: 4)
Sriwijaya Journal of Environment     Open Access  
Stochastic Environmental Research and Risk Assessment     Hybrid Journal   (Followers: 4)
Strategic Planning for Energy and the Environment     Hybrid Journal   (Followers: 4)
Studies in Conservation     Hybrid Journal   (Followers: 18)
Sustainability     Open Access   (Followers: 26)
Sustainable and Resilient Infrastructure     Hybrid Journal  
Sustainable Cities and Society     Hybrid Journal   (Followers: 25)
Sustainable Development     Hybrid Journal   (Followers: 14)
Sustainable Development Law & Policy     Open Access   (Followers: 12)
Sustainable Development Strategy and Practise     Open Access   (Followers: 4)
Sustainable Horizons     Full-text available via subscription   (Followers: 8)
Sustainable Technology and Entrepreneurship     Full-text available via subscription   (Followers: 8)
TECHNE - Journal of Technology for Architecture and Environment     Open Access   (Followers: 11)
Tecnogestión     Open Access  
Territorio della Ricerca su Insediamenti e Ambiente. Rivista internazionale di cultura urbanistica     Open Access  
The Historic Environment : Policy & Practice     Hybrid Journal   (Followers: 4)
The International Journal on Media Management     Hybrid Journal   (Followers: 6)
The Ring     Open Access  
Theoretical Ecology     Hybrid Journal   (Followers: 14)
Toxicologic Pathology     Hybrid Journal   (Followers: 8)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Toxicological Sciences     Hybrid Journal   (Followers: 10)
Toxicology     Hybrid Journal   (Followers: 14)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 16)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Toxicology in Vitro     Hybrid Journal   (Followers: 8)
Toxicology Letters     Hybrid Journal   (Followers: 12)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 7)
Toxicon     Hybrid Journal   (Followers: 2)
Toxicon : X     Open Access  
Toxin Reviews     Hybrid Journal  
Transactions on Environment and Electrical Engineering     Open Access  
Transportation Research Part D: Transport and Environment     Hybrid Journal   (Followers: 28)
Transportation Safety and Environment     Open Access   (Followers: 1)
Transylvanian Review of Systematical and Ecological Research     Open Access  
Trends in Ecology & Evolution     Full-text available via subscription   (Followers: 304)
Trends in Environmental Analytical Chemistry     Hybrid Journal   (Followers: 3)
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 17)
Tropicultura     Open Access  
UCLA Journal of Environmental Law and Policy     Open Access   (Followers: 3)
UD y la Geomática     Open Access  
Universidad y Ciencia     Open Access  
Urban Studies     Hybrid Journal   (Followers: 82)
Urban Transformations     Open Access   (Followers: 2)
VertigO - la revue électronique en sciences de l’environnement     Open Access   (Followers: 1)
Villanova Environmental Law Journal     Open Access   (Followers: 2)
Waste Management & Research     Hybrid Journal   (Followers: 7)
Water Conservation Science and Engineering     Hybrid Journal  
Water Environment Research     Full-text available via subscription   (Followers: 44)
Water International     Hybrid Journal   (Followers: 20)
Water Security     Hybrid Journal   (Followers: 6)
Water, Air, & Soil Pollution : Focus     Hybrid Journal   (Followers: 7)
Water, Air, & Soil Pollution     Open Access   (Followers: 22)
Weather and Forecasting     Hybrid Journal   (Followers: 41)
Weather, Climate, and Society     Hybrid Journal   (Followers: 14)
Web Ecology     Open Access   (Followers: 3)
Wetlands     Hybrid Journal   (Followers: 26)
Wildlife Australia     Full-text available via subscription   (Followers: 2)
Wiley Interdisciplinary Reviews - Climate Change     Hybrid Journal   (Followers: 34)
Wiley Interdisciplinary Reviews : Energy and Environment     Hybrid Journal   (Followers: 8)
William & Mary Environmental Law and Policy Review     Open Access   (Followers: 2)
World Environment     Open Access   (Followers: 2)
World Journal of Entrepreneurship, Management and Sustainable Development     Hybrid Journal   (Followers: 5)
World Journal of Environmental Engineering     Open Access   (Followers: 1)
Zoology and Ecology     Hybrid Journal   (Followers: 2)
Землеустрій, кадастр і моніторинг земель     Open Access   (Followers: 1)
气候与环境研究     Full-text available via subscription   (Followers: 2)

  First | 1 2 3 4 5     

Similar Journals
Journal Cover
Toxicological Sciences
Journal Prestige (SJR): 1.538
Citation Impact (citeScore): 4
Number of Followers: 10  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1096-6080 - ISSN (Online) 1096-0929
Published by Oxford University Press Homepage  [425 journals]
  • Effects of PFAS on human liver transporters: implications for health
           outcomes

    • Free pre-print version: Loading...

      Pages: 213 - 227
      Abstract: AbstractPer- and polyfluoroalkyl substances (PFAS) have become internationally recognized over the past three decades as persistent organic pollutants used in the production of various consumer and industrial goods. Research efforts continue to gauge the risk that historically used, and newly produced, PFAS may cause to human health. Numerous studies report toxic effects of PFAS on the human liver as well as increased serum cholesterol levels in adults. A major concern with PFAS, also dubbed “forever chemicals,” is that they accumulate in the liver and kidney and persist in serum. The mechanisms responsible for their disposition and excretion in humans are poorly understood. A better understanding of the interaction of PFAS with liver transporters, as it pertains to the disposition of PFAS and other xenobiotics, could provide mechanistic insight into human health effects and guide efforts toward risk assessment of compounds in development. This review summarizes the current state of the literature on the emerging relationships (eg, substrates, inhibitors, modulators of gene expression) between PFAS and specific hepatic transporters. The adaptive and toxicological responses of hepatocytes to PFAS that reveal linkages to pathologies and epidemiological findings are highlighted. The evidence suggests that our understanding of the molecular landscape of PFAS must improve to determine their impact on the expression and function of hepatocyte transporters that play a key role in PFAS or other xenobiotic disposition. From here, we can assess what role these changes may have in documented human health outcomes.
      PubDate: Thu, 09 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae061
      Issue No: Vol. 200, No. 2 (2024)
       
  • The dose disrupts the pathway: application of Paracelsus principle to
           mechanistic toxicology

    • Free pre-print version: Loading...

      Pages: 228 - 234
      Abstract: AbstractArguably the most famous principle of toxicology is “The dose makes the poison” formulated by Paracelsus in the 16th century. Application of the Paracelsus’s principle to mechanistic toxicology may be challenging as one compound may affect many molecular pathways at different doses with different and often nonlinear dose-response relationships. As a result, many mechanistic studies of environmental and occupational compounds use high doses of xenobiotics motivated by the need to see a clear signal indicating disruption of a particular molecular pathway. This approach ignores the possibility that the same xenobiotic may affect different molecular mechanism(s) at much lower doses relevant to human exposures. To amend mechanistic toxicology with a simple and concise guiding principle, I suggest recontextualization of Paracelsus’s following its letter and spirit: “The dose disrupts the pathway”. Justification of this statement includes observations that many environmental and occupational xenobiotics affect a broad range of molecular cascades, that most molecular pathways are sensitive to chemical exposures, and that different molecular pathways are sensitive to different doses of a chemical compound. I suggest that this statement may become a useful guidance and educational tool in a range of toxicological applications, including experimental design, comparative analysis of mechanistic hypotheses, evaluation of the quality of toxicological studies, and risk assessment.
      PubDate: Tue, 07 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae059
      Issue No: Vol. 200, No. 2 (2024)
       
  • Microplastic presence in dog and human testis and its potential
           association with sperm count and weights of testis and epididymis

    • Free pre-print version: Loading...

      Pages: 235 - 240
      Abstract: AbstractThe ubiquitous existence of microplastics and nanoplastics raises concerns about their potential impact on the human reproductive system. Limited data exists on microplastics within the human reproductive system and their potential consequences on sperm quality. Our objectives were to quantify and characterize the prevalence and composition of microplastics within both canine and human testes and investigate potential associations with the sperm count, and weights of testis and epididymis. Using advanced sensitive pyrolysis-gas chromatography/mass spectrometry, we quantified 12 types of microplastics within 47 canine and 23 human testes. Data on reproductive organ weights, and sperm count in dogs were collected. Statistical analyses, including descriptive analysis, correlational analysis, and multivariate linear regression analyses were applied to investigate the association of microplastics with reproductive functions. Our study revealed the presence of microplastics in all canine and human testes, with significant inter-individual variability. Mean total microplastic levels were 122.63 µg/g in dogs and 328.44 µg/g in humans. Both humans and canines exhibit relatively similar proportions of the major polymer types, with PE being dominant. Furthermore, a negative correlation between specific polymers such as PVC and PET and the normalized weight of the testis was observed. These findings highlight the pervasive presence of microplastics in the male reproductive system in both canine and human testes, with potential consequences on male fertility.
      PubDate: Wed, 15 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae060
      Issue No: Vol. 200, No. 2 (2024)
       
  • Evaluating the impact of anatomical and physiological variability on human
           equivalent doses using PBPK models

    • Free pre-print version: Loading...

      Pages: 241 - 264
      Abstract: AbstractAddressing human anatomical and physiological variability is a crucial component of human health risk assessment of chemicals. Experts have recommended probabilistic chemical risk assessment paradigms in which distributional adjustment factors are used to account for various sources of uncertainty and variability, including variability in the pharmacokinetic behavior of a given substance in different humans. In practice, convenient assumptions about the distribution forms of adjustment factors and human equivalent doses (HEDs) are often used. Parameters such as tissue volumes and blood flows are likewise often assumed to be lognormally or normally distributed without evaluating empirical data for consistency with these forms. In this work, we performed dosimetric extrapolations using physiologically based pharmacokinetic (PBPK) models for dichloromethane (DCM) and chloroform that incorporate uncertainty and variability to determine if the HEDs associated with such extrapolations are approximately lognormal and how they depend on the underlying distribution shapes chosen to represent model parameters. We accounted for uncertainty and variability in PBPK model parameters by randomly drawing their values from a variety of distribution types. We then performed reverse dosimetry to calculate HEDs based on animal points of departure for each set of sampled parameters. Corresponding samples of HEDs were tested to determine the impact of input parameter distributions on their central tendencies, extreme percentiles, and degree of conformance to lognormality. This work demonstrates that the measurable attributes of human variability should be considered more carefully and that generalized assumptions about parameter distribution shapes may lead to inaccurate estimates of extreme percentiles of HEDs.
      PubDate: Sat, 25 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae067
      Issue No: Vol. 200, No. 2 (2024)
       
  • Effects of combustible cigarettes and heated tobacco products on immune
           cell-driven inflammation in chronic obstructive respiratory diseases

    • Free pre-print version: Loading...

      Pages: 265 - 276
      Abstract: AbstractSince long-term effects of heated tobacco products (HTP) on the progression of chronic obstructive pulmonary disease (COPD) are unknown, we used COPD mice model to compare immune cell-dependent pathological changes in the lungs of animals which were exposed to HTP or combustible cigarettes (CCs). We also performed intracellular staining and flow cytometry analysis of immune cells which were present in the blood of CCs and HTP users who suffered from immune cell-driven chronic obstructive respiratory diseases. CCs enhanced NLRP3 inflammasome-dependent production of inflammatory cytokines in lung-infiltrated neutrophils and macrophages and increased influx of cytotoxic Th1, Th2, and Th17 lymphocytes in the lungs of COPD mice. Similarly, CCs promoted generation of inflammatory phenotype in circulating leukocytes of COPD patients. Opposite to CCs, HTP favored expansion of immunosuppressive, IL-10-producing, FoxP3-expressing T, NK, and NKT cells in inflamed lungs of COPD mice. Compared with CCs, HTP had weaker capacity to promote synthesis of inflammatory cytokines in lung-infiltrated immune cells. Significantly lower number of inflammatory neutrophils, monocytes, Th1, Th2, and Th17 lymphocytes were observed in the blood of patients who consumed HTP than in the blood of CCs users, indicating different effects of CCs and HTP on immune cells’ phenotype and function.
      PubDate: Fri, 24 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae068
      Issue No: Vol. 200, No. 2 (2024)
       
  • Cross study analyses of SEND data: toxicity profile classification

    • Free pre-print version: Loading...

      Pages: 277 - 286
      Abstract: AbstractA SEND toxicology data transformation, harmonization, and analysis platform were created to improve the identification of unique findings related to the intended target, species, and duration of dosing using data from multiple studies. The lack of a standardized digital format for data analysis had impeded large-scale analysis of in vivo toxicology studies. The CDISC SEND standard enables the analysis of data from multiple studies performed by different laboratories. This work describes methods to analyze data and automate cross-study analysis of toxicology studies. Cross-study analysis can be used to understand a single compound’s toxicity profile across all studies performed and/or to evaluate on-target versus off-target toxicity for multiple compounds intended for the same pharmacological target. This work involved development of data harmonization/transformation strategies to enable cross-study analysis of both numerical and categorical SEND data. Four de-identified SEND datasets from the BioCelerate database were used for the analyses. Toxicity profiles for key organ systems were developed for liver, kidney, male reproductive tract, endocrine system, and hematopoietic system using SEND domains. A cross-study analysis dashboard with a built-in user-defined scoring system was created for custom analyses, including visualizations to evaluate data at the organ system level and drill down into individual animal data. This data analysis provides the tools for scientists to compare toxicity profiles across multiple studies using SEND. A cross-study analysis of 2 different compounds intended for the same pharmacological target is described and the analyses indicate potential on-target effects to liver, kidney, and hematopoietic systems.
      PubDate: Sat, 08 Jun 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae072
      Issue No: Vol. 200, No. 2 (2024)
       
  • Single-cell insights into mouse testicular toxicity under peripubertal
           exposure to di(2-ethylhexyl) phthalate

    • Free pre-print version: Loading...

      Pages: 287 - 298
      Abstract: AbstractMale fertility depends on normal pubertal development. Di-(2-ethylhexyl) phthalate (DEHP) is a potent antiandrogen chemical, and exposure to DEHP during peripuberty can damage the developing male reproductive system, especially the testis. However, the specific cellular targets and differentiation processes affected by DEHP, which lead to testicular toxicity, remain poorly defined. Herein, we presented the first single-cell transcriptomic profile of the pubertal mouse testis following DEHP exposure. To carry out the experiment, 2 groups (n = 8 each) of 3-week-old male mice were orally administered 0.5% carboxymethylcellulose sodium salt or 100 mg/kg body weight DEHP daily from postnatal day 21–48, respectively. Using single-cell RNA sequencing, a total of 31 distinct cell populations were identified, notably, Sertoli and Leydig cells emerged as important targets of DEHP. DEHP exposure significantly decreased the proportions of Sertoli cell clusters expressing mature Sertoli markers (Sox9 and Ar), and selectively reduced the expression of testosterone synthesis genes in fetal Leydig cells. Through cell–cell interaction analyses, we observed changed numbers of interactions in Sertoli cells 1 (SCs1), Leydig cells 1 (LCs1), and interstitial macrophages, and we also identified cell-specific ligand gene expressions in these clusters, such as Inha, Fyn, Vcam1, and Apoe. Complementary in vitro assays confirmed that DEHP directly reduced the expression of genes related to Sertoli cell adhesion and intercellular communication. In conclusion, peripubertal DEHP exposure reduced the number of mature Sertoli cells and may disrupt testicular steroidogenesis by affecting the testosterone synthesis genes in fetal Leydig cells rather than adult Leydig cells.
      PubDate: Fri, 10 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae064
      Issue No: Vol. 200, No. 2 (2024)
       
  • Effects of ozone exposure on lung injury, inflammation, and oxidative
           stress in a murine model of nonpneumonic endotoxemia

    • Free pre-print version: Loading...

      Pages: 299 - 311
      Abstract: AbstractRecent studies have identified exposure to environmental levels of ozone as a risk factor for the development of acute respiratory distress syndrome (ARDS), a severe form of acute lung injury (ALI) that can develop in humans with sepsis. The aim of this study was to develop a murine model of ALI to mechanistically explore the impact of ozone exposure on ARDS development. Mice were exposed to ozone (0.8 ppm, 3 h) or air control followed 24 h later by intravenous administration of 3 mg/kg lipopolysaccharide (LPS) or PBS. Exposure of mice to ozone + LPS caused alveolar hyperplasia; increased BAL levels of albumin, IgM, phospholipids, and proinflammatory mediators including surfactant protein D and soluble receptor for advanced glycation end products were also detected in BAL, along with markers of oxidative and nitrosative stress. Administration of ozone + LPS resulted in an increase in neutrophils and anti-inflammatory macrophages in the lung, with no effects on proinflammatory macrophages. Conversely, the numbers of resident alveolar macrophages decreased after ozone + LPS; however, expression of Nos2, Arg1, Cxcl1, Cxcl2, Ccl2 by these cells increased, indicating that they are activated. These findings demonstrate that ozone sensitizes the lung to respond to endotoxin, resulting in ALI, oxidative stress, and exacerbated pulmonary inflammation, and provide support for the epidemiologic association between ozone exposure and ARDS incidence.
      PubDate: Wed, 15 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae062
      Issue No: Vol. 200, No. 2 (2024)
       
  • PFAS and their association with the increased risk of cardiovascular
           disease in postmenopausal women

    • Free pre-print version: Loading...

      Pages: 312 - 323
      Abstract: AbstractCardiovascular diseases (CVDs) are one of the major causes of death globally. In addition to traditional risk factors such as unhealthy lifestyles (smoking, obesity, sedentary) and genetics, common environmental exposures, including persistent environmental contaminants, may also influence CVD risk. Per- and polyfluoroalkyl substances (PFASs) are a class of highly fluorinated chemicals used in household consumer and industrial products known to persist in our environment for years, causing health concerns that are now linked to endocrine disruptions and related outcomes in women, including interference of the cardiovascular and reproductive systems. In postmenopausal women, higher levels of PFAS are observed than in premenopausal women due to the cessation of menstruation, which is crucial for PFAS excretion. Because of these findings, we explored the association between perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorobutanesulfonic acid in postmenopausal women from our previously established CVD study. We used liquid chromatography with tandem mass spectrometry, supported by machine learning approaches, and the detection and quantification of serum metabolites and proteins. Here, we show that PFOS can be a good predictor of coronary artery disease, whereas PFOA can be an intermediate predictor of coronary microvascular disease. We also found that the PFAS levels in our study are significantly associated with inflammation-related proteins. Our findings may provide new insight into the potential mechanisms underlying the PFAS-induced risk of CVDs in this population.This study shows that exposure to PFOA and PFOS is associated with an increased risk of cardiovascular disease in postmenopausal women. PFOS and PFOA levels correlate with amino acids and proteins related to inflammation. These circulating biomarkers contribute to the etiology of CVD and potentially implicate a mechanistic relationship between PFAS exposure and increased risk of cardiovascular events in this population.
      PubDate: Fri, 17 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae065
      Issue No: Vol. 200, No. 2 (2024)
       
  • Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive
           androstane receptor: primary and secondary gene responses with links to
           disease progression

    • Free pre-print version: Loading...

      Pages: 324 - 345
      Abstract: AbstractConstitutive androstane receptor (CAR, Nr1i3), a liver nuclear receptor and xenobiotic sensor, induces drug, steroid, and lipid metabolizing enzymes, stimulates liver hypertrophy and hyperplasia, and ultimately, hepatocellular carcinogenesis. The mechanisms linking early CAR responses to later disease development are poorly understood. Here we show that exposure of CD-1 mice to TCPOBOP (1,4-bis[2-(3,5-dichloropyridyloxy)]benzene), a halogenated xenochemical and selective CAR agonist ligand, induces pericentral steatosis marked by hepatic accumulation of cholesterol and neutral lipid, and elevated circulating alanine aminotransferase, indicating hepatocyte damage. TCPOBOP-induced steatosis was weaker in the pericentral region but stronger in the periportal region in females compared with males. Early (1 day) TCPOBOP transcriptional responses were enriched for CAR-bound primary response genes, and for lipogenesis and xenobiotic metabolism and oxidative stress protection pathways; late (2 weeks) TCPOBOP responses included many CAR binding-independent secondary response genes, with enrichment for macrophage activation, immune response, and cytokine and reactive oxygen species production. Late upstream regulators specific to TCPOBOP-exposed male liver were linked to proinflammatory responses and hepatocellular carcinoma progression. TCPOBOP administered weekly to male mice using a high corn oil vehicle induced carbohydrate-responsive transcription factor (MLXIPL)-regulated target genes, dysregulated mitochondrial respiratory and translation regulatory pathways, and induced more advanced liver pathology. Overall, TCPOBOP exposure recapitulates histological and gene expression changes characteristic of emerging steatotic liver disease, including secondary gene responses in liver nonparenchymal cells indicative of transition to a more advanced disease state. Upstream regulators of both the early and late TCPOBOP response genes include novel biomarkers for foreign chemical-induced metabolic dysfunction-associated steatotic liver disease.
      PubDate: Mon, 06 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae057
      Issue No: Vol. 200, No. 2 (2024)
       
  • Regulation of hepatic xenosensor function by HNF4alpha

    • Free pre-print version: Loading...

      Pages: 346 - 356
      Abstract: AbstractNuclear receptors such as constitutive androstane receptor (CAR), pregnane X receptor (PXR), and peroxisome proliferator-activated receptor-alpha (PPARα), and transcription factors with nuclear receptor type activity such as aryl hydrocarbon receptor (AhR) function as xenobiotic sensors. Hepatocyte nuclear factor 4alpha (HNF4α) is a highly conserved orphan nuclear receptor essential for liver function. We tested the hypothesis that HNF4α is essential for the function of these 4 major xenosensors. Wild-type (WT) and hepatocyte-specific Hnf4a null (HNF4α-KO) mice were treated with the mouse-specific activators of AhR (TCDD, 30 µg/kg), CAR (TCPOBOP, 2.5 µg/g), PXR, (PCN, 100 µg/g), and PPARα (WY-14643, 1 mg/kg). Blood and liver tissue samples were collected to study receptor activation. TCDD (AhR agonist) treatment did not affect the liver-to-body weight ratio (LW/BW) in either WT or HNF4α-KO mice. Further, TCDD activated AhR in both WT and HNF4α-KO mice, confirmed by increase in expression of AhR target genes. TCPOBOP (CAR agonist) significantly increased the LW/BW ratio and CAR target gene expression in WT mice, but not in HNF4α-KO mice. PCN (a mouse PXR agonist) significantly increased LW/BW ratio in both WT and HNF4α-KO mice however, failed to induce PXR target genes in HNF4α-KO mice. The treatment of WY-14643 (PPARα agonist) increased LW/BW ratio and PPARα target gene expression in WT mice but not in HNF4α-KO mice. Together, these data indicate that the function of CAR, PXR, and PPARα but not of AhR was disrupted in HNF4α-KO mice. These results demonstrate that HNF4α function is critical for the activation of hepatic xenosensors, which are critical for toxicological responses.
      PubDate: Wed, 29 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae069
      Issue No: Vol. 200, No. 2 (2024)
       
  • Ferrostatin-1 mitigates cellular damage in a ferroptosis-like environment
           in Caenorhabditis elegans

    • Free pre-print version: Loading...

      Pages: 357 - 368
      Abstract: AbstractAlthough iron (Fe) is the most biologically abundant transition metal, it is highly toxic when it accumulates as Fe2+, forming a labile Fe pool and favoring the Fenton reaction. This oxidative scenario leads to a type of caspase-independent programmed cell death, referred to as ferroptosis, where following processes take place: (i) Fe2+ overload, (ii) glutathione peroxidase 4 inactivation, (iii) lipid peroxidation, and (iv) glutathione depletion. The present study sought to evaluate the consequences of Fe2+ administration on ferroptosis induction in Caenorhabditis elegans. We demonstrated higher mortality, increased lipid peroxidation, reduced glutathione peroxidase activity, and morphological damage in dopaminergic neurons upon Fe2+ overload. Pharmacological intervention at the level of lipid peroxidation with ferrostatin-1 (250 μM) mitigated the damage and returned the biochemical parameters to basal levels, revealing the potential of this therapeutical approach. Finally, to assess the relationship between ferroptosis and dopamine in a Parkinsonian background, we evaluated the UA44 worm strain which overexpresses the alpha-synuclein protein in cherry-labeled dopaminergic neurons. We demonstrated that Fe2+ administration reduced lethality associated with similar alterations in biochemical and dopaminergic morphological parameters in wild-type animals. These experiments provide mechanistic-based evidence on the efficacy of a pharmacological approach to mitigate the physiological, biochemical, and morphological consequences of Fe2+ overload. At the same time, they encourage further research on the impact of the combined effects resulting from the genetic background and dopamine signaling in a Parkinsonian phenotype.
      PubDate: Thu, 16 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae066
      Issue No: Vol. 200, No. 2 (2024)
       
  • Drug-induced impairment of mitochondrial fatty acid oxidation and
           steatosis: assessment of causal relationship with 45 pharmaceuticals

    • Free pre-print version: Loading...

      Pages: 369 - 381
      Abstract: AbstractDrug-induced liver injury (DILI) represents a major issue for pharmaceutical companies, being a potential cause of black-box warnings on marketed pharmaceuticals, or drug withdrawal from the market. Lipid accumulation in the liver also referred to as steatosis, may be secondary to impaired mitochondrial fatty acid oxidation (mtFAO). However, an overall causal relationship between drug-induced mtFAO inhibition and the occurrence of steatosis in patients has not yet been established with a high number of pharmaceuticals. Hence, 32 steatogenic and 13 nonsteatogenic drugs were tested for their ability to inhibit mtFAO in isolated mouse liver mitochondria. To this end, mitochondrial respiration was measured with palmitoyl-l-carnitine, palmitoyl-CoA + l-carnitine, or octanoyl- l-carnitine. This mtFAO tri-parametric assay was able to predict the occurrence of steatosis in patients with a sensitivity and positive predictive value above 88%. To get further information regarding the mechanism of drug-induced mtFAO impairment, mitochondrial respiration was also measured with malate/glutamate or succinate. Drugs such as diclofenac, methotrexate, and troglitazone could inhibit mtFAO secondary to an impairment of the mitochondrial respiratory chain, whereas dexamethasone, olanzapine, and zidovudine appeared to impair mtFAO directly. Mitochondrial swelling, transmembrane potential, and production of reactive oxygen species were also assessed for all compounds. Only the steatogenic drugs amiodarone, ketoconazole, lovastatin, and toremifene altered all these 3 mitochondrial parameters. In conclusion, our tri-parametric mtFAO assay could be useful in predicting the occurrence of steatosis in patients. The combination of this assay with other mitochondrial parameters could also help to better understand the mechanism of drug-induced mtFAO inhibition.
      PubDate: Sat, 27 Apr 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae055
      Issue No: Vol. 200, No. 2 (2024)
       
  • The use of PD-1 functional knockout rats to study idiosyncratic adverse
           reactions to nevirapine

    • Free pre-print version: Loading...

      Pages: 382 - 393
      Abstract: AbstractIdiosyncratic drug reactions (IDRs) are associated with significant patient morbidity/mortality and lead to considerable drug candidate attrition in drug development. Their idiosyncratic nature makes the study of IDRs difficult. In particular, nevirapine is associated with a relatively high risk of serious skin rash and liver injury. We previously found that nevirapine causes a similar skin rash in female Brown Norway rats, but these animals do not develop significant liver injury. Programmed cell death protein-1 (PD-1) is an immune checkpoint involved in immune tolerance, and anti-PD-1 antibodies have been used to treat cancer. However, they increase the risk of liver injury caused by co-administered drugs. We found that PD-1−/− mice are more susceptible to drug-induced liver injury, but PD-1−/− mice are not a good model for all drugs. In particular, they do not develop a skin rash when treated with nevirapine, at least in part because they lack the sulfotransferase in their skin that forms the reactive metabolite responsible for the rash. Therefore, we developed a PD-1 mutant (PD-1m/m) rat, with an excision in the ligand-binding domain of PD-1, to test whether nevirapine would cause a more serious skin rash in these animals. The PD-1m/m rat was based on a Sprague Dawley background, which has a lower incidence of skin rash than Brown Norway rats. The treated PD-1m/m rats developed more severe liver injury than PD-1−/− mice, but in contrast to expectations, they did not develop a skin rash. Functional knockouts provide a unique tool to study the mechanisms of IDRs.
      PubDate: Wed, 15 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae058
      Issue No: Vol. 200, No. 2 (2024)
       
  • Comparative toxicological assessment of 2 bisphenols using a systems
           approach: evaluation of the behavioral and transcriptomic responses of
           Danio rerio to bisphenol A and tetrabromobisphenol A

    • Free pre-print version: Loading...

      Pages: 394 - 403
      Abstract: AbstractThe zebrafish (Danio rerio) is becoming a critical component of new approach methods (NAMs) in chemical risk assessment. As a whole organism in vitro NAM, the zebrafish model offers significant advantages over individual cell-line testing, including toxicokinetic and toxicodynamic competencies. A transcriptomic approach not only allows for insight into mechanism of action for both apical endpoints and unobservable adverse outcomes, but also changes in gene expression induced by lower, environmentally relevant concentrations. In this study, we used a larval zebrafish model to assess the behavioral and transcriptomic alterations caused by subphenotypic concentrations of 2 chemicals with the same structural backbone, the endocrine-disrupting chemicals bisphenol A and tetrabromobisphenol A. Following assessment of behavioral toxicity, we used a transcriptomic approach to identify molecular pathways associated with previously described phenotypes. We also determined the transcriptomic point of departure for each chemical by modeling gene expression changes as continuous systems which allows for the identification of a single concentration at which toxic effects can be predicted. This can then be investigated with confirmatory cell-based testing in an integrated approach to testing and assessment to determine risk to human health and the environment with greater confidence. This paper demonstrates the impact of using a multi-faceted approach for evaluating the physiological and neurotoxic effects of exposure to structurally related chemicals. By comparing phenotypic effects with transcriptomic outcomes, we were able to differentiate, characterize, and rank the toxicities of related bisphenols, which demonstrates methodological advantages unique to the larval zebrafish NAM.
      PubDate: Fri, 10 May 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae063
      Issue No: Vol. 200, No. 2 (2024)
       
  • The association between histopathologic effects and liver weight changes
           induced in mice and rats by chemical exposures: an analysis of the data
           from Toxicity Reference Database (ToxRefDB)

    • Free pre-print version: Loading...

      Pages: 404 - 413
      Abstract: AbstractAbsolute (ALW) and relative (RLW) liver weight changes are sensitive endpoints in repeat-dose rodent toxicity studies, and their changes are often used for quantitative assessment of health effects induced by hepatotoxic chemicals using the benchmark dose-response modeling (BMD) approach. To find biologically relevant liver weight changes to chemical exposures, we evaluated all data available for liver weight changes and associated liver histopathologic findings from the Toxicity Reference Database (ToxRefDB). Our analysis of 389 subchronic mouse and rat studies for 273 chemicals found significant differences in treatment-related ALW and RLW changes between dose groups with and without liver histopathologic changes. In addition, we demonstrate that chemical treatment-induced ALW and RLW changes can predict the presence of histopathologic findings and inform the selection of biologically relevant liver weight changes for BMD modeling and derivation of toxicity values.
      PubDate: Wed, 24 Apr 2024 00:00:00 GMT
      DOI: 10.1093/toxsci/kfae056
      Issue No: Vol. 200, No. 2 (2024)
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 18.97.14.80
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-
JournalTOCs
 
 
  Subjects -> ENVIRONMENTAL STUDIES (Total: 913 journals)
    - ENVIRONMENTAL STUDIES (810 journals)
    - POLLUTION (31 journals)
    - TOXICOLOGY AND ENVIRONMENTAL SAFETY (54 journals)
    - WASTE MANAGEMENT (18 journals)

ENVIRONMENTAL STUDIES (810 journals)            First | 1 2 3 4 5     

Showing 601 - 378 of 378 Journals sorted alphabetically
Research and Practice for Persons with Severe Disabilities     Full-text available via subscription   (Followers: 4)
Research Journal of Environmental Sciences     Open Access   (Followers: 2)
Research Journal of Environmental Toxicology     Open Access   (Followers: 2)
Resources     Open Access  
Resources and Environment     Open Access   (Followers: 2)
Resources, Conservation & Recycling     Hybrid Journal   (Followers: 21)
Resources, Conservation & Recycling : X     Open Access   (Followers: 1)
Resources, Conservation & Recycling Advances     Open Access   (Followers: 2)
Rethinking Ecology     Open Access  
Reuse/Recycle Newsletter     Hybrid Journal  
Review of Agricultural, Food and Environmental Studies     Hybrid Journal  
Review of Environmental Economics and Policy     Hybrid Journal   (Followers: 13)
Revista Brasileira de Ciências Ambientais     Open Access   (Followers: 3)
Revista Brasileira de Meio Ambiente     Open Access  
Revista de Ciencias Ambientales     Open Access  
Revista de Direito e Sustentabilidade     Open Access  
Revista de Gestão Ambiental e Sustentabilidade - GeAS     Open Access  
Revista de Salud Ambiental     Open Access  
Revista Eletrônica de Gestão e Tecnologias Ambientais     Open Access  
Revista Kawsaypacha: Sociedad y Medio Ambiente     Open Access  
Revista Laborativa     Open Access  
Revista Verde de Agroecologia e Desenvolvimento Sustentável     Open Access   (Followers: 4)
RUDN Journal of Ecology and Life Safety     Open Access  
Russian Journal of Ecology     Hybrid Journal   (Followers: 1)
Safety Science     Hybrid Journal   (Followers: 32)
SAR and QSAR in Environmental Research     Hybrid Journal   (Followers: 1)
Scandinavian Journal of Work, Environment & Health     Partially Free   (Followers: 14)
Science of The Total Environment     Hybrid Journal   (Followers: 45)
Smart Grid and Renewable Energy     Open Access   (Followers: 9)
Social and Environmental Accountability Journal     Hybrid Journal   (Followers: 3)
Soil and Sediment Contamination: An International Journal     Hybrid Journal   (Followers: 3)
Soil and Tillage Research     Hybrid Journal   (Followers: 10)
South Pacific Journal of Natural and Applied Sciences     Hybrid Journal  
Southern African Journal of Environmental Education     Open Access  
Southern Forests : a Journal of Forest Science     Hybrid Journal   (Followers: 4)
Sriwijaya Journal of Environment     Open Access  
Stochastic Environmental Research and Risk Assessment     Hybrid Journal   (Followers: 4)
Strategic Planning for Energy and the Environment     Hybrid Journal   (Followers: 4)
Studies in Conservation     Hybrid Journal   (Followers: 18)
Sustainability     Open Access   (Followers: 26)
Sustainable and Resilient Infrastructure     Hybrid Journal  
Sustainable Cities and Society     Hybrid Journal   (Followers: 25)
Sustainable Development     Hybrid Journal   (Followers: 14)
Sustainable Development Law & Policy     Open Access   (Followers: 12)
Sustainable Development Strategy and Practise     Open Access   (Followers: 4)
Sustainable Horizons     Full-text available via subscription   (Followers: 8)
Sustainable Technology and Entrepreneurship     Full-text available via subscription   (Followers: 8)
TECHNE - Journal of Technology for Architecture and Environment     Open Access   (Followers: 11)
Tecnogestión     Open Access  
Territorio della Ricerca su Insediamenti e Ambiente. Rivista internazionale di cultura urbanistica     Open Access  
The Historic Environment : Policy & Practice     Hybrid Journal   (Followers: 4)
The International Journal on Media Management     Hybrid Journal   (Followers: 6)
The Ring     Open Access  
Theoretical Ecology     Hybrid Journal   (Followers: 14)
Toxicologic Pathology     Hybrid Journal   (Followers: 8)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Toxicological Sciences     Hybrid Journal   (Followers: 10)
Toxicology     Hybrid Journal   (Followers: 14)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 16)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Toxicology in Vitro     Hybrid Journal   (Followers: 8)
Toxicology Letters     Hybrid Journal   (Followers: 12)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 7)
Toxicon     Hybrid Journal   (Followers: 2)
Toxicon : X     Open Access  
Toxin Reviews     Hybrid Journal  
Transactions on Environment and Electrical Engineering     Open Access  
Transportation Research Part D: Transport and Environment     Hybrid Journal   (Followers: 28)
Transportation Safety and Environment     Open Access   (Followers: 1)
Transylvanian Review of Systematical and Ecological Research     Open Access  
Trends in Ecology & Evolution     Full-text available via subscription   (Followers: 304)
Trends in Environmental Analytical Chemistry     Hybrid Journal   (Followers: 3)
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 17)
Tropicultura     Open Access  
UCLA Journal of Environmental Law and Policy     Open Access   (Followers: 3)
UD y la Geomática     Open Access  
Universidad y Ciencia     Open Access  
Urban Studies     Hybrid Journal   (Followers: 82)
Urban Transformations     Open Access   (Followers: 2)
VertigO - la revue électronique en sciences de l’environnement     Open Access   (Followers: 1)
Villanova Environmental Law Journal     Open Access   (Followers: 2)
Waste Management & Research     Hybrid Journal   (Followers: 7)
Water Conservation Science and Engineering     Hybrid Journal  
Water Environment Research     Full-text available via subscription   (Followers: 44)
Water International     Hybrid Journal   (Followers: 20)
Water Security     Hybrid Journal   (Followers: 6)
Water, Air, & Soil Pollution : Focus     Hybrid Journal   (Followers: 7)
Water, Air, & Soil Pollution     Open Access   (Followers: 22)
Weather and Forecasting     Hybrid Journal   (Followers: 41)
Weather, Climate, and Society     Hybrid Journal   (Followers: 14)
Web Ecology     Open Access   (Followers: 3)
Wetlands     Hybrid Journal   (Followers: 26)
Wildlife Australia     Full-text available via subscription   (Followers: 2)
Wiley Interdisciplinary Reviews - Climate Change     Hybrid Journal   (Followers: 34)
Wiley Interdisciplinary Reviews : Energy and Environment     Hybrid Journal   (Followers: 8)
William & Mary Environmental Law and Policy Review     Open Access   (Followers: 2)
World Environment     Open Access   (Followers: 2)
World Journal of Entrepreneurship, Management and Sustainable Development     Hybrid Journal   (Followers: 5)
World Journal of Environmental Engineering     Open Access   (Followers: 1)
Zoology and Ecology     Hybrid Journal   (Followers: 2)
Землеустрій, кадастр і моніторинг земель     Open Access   (Followers: 1)
气候与环境研究     Full-text available via subscription   (Followers: 2)

  First | 1 2 3 4 5     

Similar Journals
Similar Journals
HOME > Browse the 73 Subjects covered by JournalTOCs  
SubjectTotal Journals
 
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 18.97.14.80
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-