Subjects -> ENVIRONMENTAL STUDIES (Total: 913 journals)
    - ENVIRONMENTAL STUDIES (810 journals)
    - POLLUTION (31 journals)
    - TOXICOLOGY AND ENVIRONMENTAL SAFETY (54 journals)
    - WASTE MANAGEMENT (18 journals)

ENVIRONMENTAL STUDIES (810 journals)            First | 1 2 3 4 5     

Showing 601 - 378 of 378 Journals sorted alphabetically
Microplastics and Nanoplastics     Open Access   (Followers: 1)
Mine Water and the Environment     Hybrid Journal   (Followers: 6)
Mitigation and Adaptation Strategies for Global Change     Open Access   (Followers: 8)
Modeling Earth Systems and Environment     Hybrid Journal   (Followers: 1)
Monteverdia     Open Access   (Followers: 1)
Multequina     Open Access  
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis     Hybrid Journal   (Followers: 5)
Mutation Research/Genetic Toxicology and Environmental Mutagenesis     Hybrid Journal   (Followers: 8)
Nano Select     Open Access   (Followers: 1)
Nanotechnology for Environmental Engineering     Hybrid Journal  
Nativa     Open Access   (Followers: 1)
Natur und Recht     Hybrid Journal   (Followers: 6)
Natural Areas Journal     Full-text available via subscription   (Followers: 10)
Natural Hazards     Hybrid Journal   (Followers: 60)
Natural Resources     Open Access  
Natural Resources & Engineering     Hybrid Journal  
Natural Resources and Environmental Issues     Open Access   (Followers: 2)
Nature and Culture     Full-text available via subscription   (Followers: 12)
Nature-Based Solutions     Open Access   (Followers: 3)
Nepal Journal of Environmental Science     Open Access   (Followers: 4)
NeuroToxicology     Hybrid Journal   (Followers: 1)
Neurotoxicology and Teratology     Hybrid Journal   (Followers: 3)
NEW SOLUTIONS: A Journal of Environmental and Occupational Health Policy     Full-text available via subscription   (Followers: 2)
New Zealand Journal of Environmental Law     Full-text available via subscription   (Followers: 6)
NJAS : Wageningen Journal of Life Sciences     Hybrid Journal  
Novos Cadernos NAEA     Open Access  
npj Urban Sustainability     Open Access  
Observatorio Medioambiental     Open Access  
Occupational and Environmental Medicine     Hybrid Journal   (Followers: 18)
Ochrona Srodowiska i Zasobów Naturalnych : Environmental Protection and Natural Resources     Open Access  
Oecologia     Hybrid Journal   (Followers: 56)
Oikos     Hybrid Journal   (Followers: 58)
One Earth     Hybrid Journal   (Followers: 5)
One Ecosystem     Open Access  
Open Environmental Research Journal     Open Access   (Followers: 1)
Open Journal of Ecology     Open Access   (Followers: 8)
Open Journal of Marine Science     Open Access   (Followers: 6)
Open Journal of Modern Hydrology     Open Access   (Followers: 6)
Our Nature     Open Access   (Followers: 2)
Pace Environmental Law Review     Open Access   (Followers: 5)
Packaging, Transport, Storage & Security of Radioactive Material     Hybrid Journal   (Followers: 3)
Palaeobiodiversity and Palaeoenvironments     Hybrid Journal   (Followers: 3)
Particle and Fibre Toxicology     Open Access   (Followers: 2)
Pastos y Forrajes     Open Access  
Peer Community Journal     Open Access   (Followers: 6)
Perspectives in Ecology and Conservation     Full-text available via subscription   (Followers: 6)
Pharmacology & Therapeutics     Hybrid Journal   (Followers: 3)
Pharmacology Biochemistry and Behavior     Hybrid Journal   (Followers: 2)
Physio-Géo     Open Access   (Followers: 1)
Pittsburgh Journal of Environmental and Public Health Law     Open Access   (Followers: 1)
Planet     Open Access   (Followers: 4)
Planeta Amazônia : Revista Internacional de Direito Ambiental e Políticas Públicas     Open Access  
Planning & Environmental Law: Issues and decisions that impact the built and natural environments     Hybrid Journal   (Followers: 8)
Plant Ecology & Diversity     Partially Free   (Followers: 13)
Plant Knowledge Journal     Open Access   (Followers: 2)
Plant, Cell & Environment     Hybrid Journal   (Followers: 10)
Plant-Environment Interactions     Open Access  
Plants, People, Planet     Open Access   (Followers: 2)
Polar Journal     Hybrid Journal   (Followers: 1)
Political Studies     Hybrid Journal   (Followers: 45)
Political Studies Review     Hybrid Journal   (Followers: 19)
Population and Environment     Hybrid Journal   (Followers: 6)
Population Ecology     Hybrid Journal   (Followers: 12)
Practice Periodical of Hazardous, Toxic, and Radioactive Waste Management     Full-text available via subscription  
Presence: Virtual and Augmented Reality     Hybrid Journal   (Followers: 3)
Proceedings of the Institution of Civil Engineers - Waste and Resource Management     Hybrid Journal   (Followers: 1)
Proceedings of the Institution of Mechanical Engineers Part M: Journal of Engineering for the Maritime Environment     Hybrid Journal   (Followers: 3)
Proceedings of the International Academy of Ecology and Environmental Sciences     Open Access   (Followers: 2)
Proceedings of the Vertebrate Pest Conference     Open Access   (Followers: 2)
Process Integration and Optimization for Sustainability     Hybrid Journal  
Process Safety and Environmental Protection     Hybrid Journal   (Followers: 4)
Producción + Limpia     Open Access  
Progress in Disaster Science     Open Access   (Followers: 3)
Progress in Industrial Ecology, An International Journal     Hybrid Journal   (Followers: 2)
Projets de Paysage     Open Access   (Followers: 1)
Psychological Assessment     Full-text available via subscription   (Followers: 14)
Public Money & Management     Hybrid Journal   (Followers: 7)
Quaternary     Open Access   (Followers: 2)
Recursos Rurais     Open Access  
REDER : Revista de Estudios Latinoamericanos sobre Reducción del Riesgo de Desastres     Open Access  
Regional Environmental Change     Open Access   (Followers: 3)
Regional Sustainability     Open Access  
Rekayasa     Open Access   (Followers: 2)
Remediation Journal     Hybrid Journal   (Followers: 8)
Remote Sensing Applications : Society and Environment     Full-text available via subscription   (Followers: 11)
Remote Sensing Letters     Hybrid Journal   (Followers: 48)
Rendiconti Lincei     Hybrid Journal  
Renewable Energy and Environmental Sustainability     Open Access   (Followers: 3)
Renewable Energy Focus     Full-text available via subscription   (Followers: 7)
Research & Reviews : Journal of Ecology     Full-text available via subscription   (Followers: 3)
Research and Practice for Persons with Severe Disabilities     Full-text available via subscription   (Followers: 4)
Research Journal of Environmental Sciences     Open Access   (Followers: 2)
Research Journal of Environmental Toxicology     Open Access   (Followers: 2)
Resources     Open Access  
Resources and Environment     Open Access   (Followers: 2)
Resources, Conservation & Recycling     Hybrid Journal   (Followers: 20)
Resources, Conservation & Recycling : X     Open Access   (Followers: 1)
Resources, Conservation & Recycling Advances     Open Access   (Followers: 1)
Rethinking Ecology     Open Access  
Reuse/Recycle Newsletter     Hybrid Journal  
Review of Agricultural, Food and Environmental Studies     Hybrid Journal  
Review of Environmental Economics and Policy     Hybrid Journal   (Followers: 13)
Revista AIDIS de Ingeniería y Ciencias Ambientales. Investigación, desarrollo y práctica     Open Access  
Revista Ambivalências     Open Access  
Revista Brasileira de Ciências Ambientais     Open Access   (Followers: 3)
Revista Brasileira de Meio Ambiente     Open Access  
Revista Chapingo. Serie Ciencias Forestales y del Ambiente     Open Access  
Revista Ciência, Tecnologia & Ambiente     Open Access  
Revista de Ciencias Ambientales     Open Access  
Revista de Direito Ambiental e Socioambientalismo     Open Access  
Revista de Direito e Sustentabilidade     Open Access  
Revista de Gestão Ambiental e Sustentabilidade - GeAS     Open Access  
Revista de Investigación en Agroproducción Sustentable     Open Access  
Revista de Salud Ambiental     Open Access  
Revista ECOVIDA     Open Access   (Followers: 4)
Revista Eletrônica de Gestão e Tecnologias Ambientais     Open Access  
Revista Geama     Open Access  
Revista Hábitat Sustenable     Open Access  
Revista Iberoamericana Ambiente & Sustentabilidad     Open Access  
Revista Kawsaypacha: Sociedad y Medio Ambiente     Open Access  
Revista Laborativa     Open Access  
Revista Meio Ambiente e Sustentabilidade     Open Access  
Revista Mundi Meio Ambiente e Agrárias     Open Access  
Revista Verde de Agroecologia e Desenvolvimento Sustentável     Open Access   (Followers: 3)
Rivista di Studi sulla Sostenibilità     Full-text available via subscription   (Followers: 2)
RUDN Journal of Ecology and Life Safety     Open Access  
Russian Journal of Ecology     Hybrid Journal   (Followers: 1)
Safety Science     Hybrid Journal   (Followers: 30)
San Francisco Estuary and Watershed Science     Open Access  
SAR and QSAR in Environmental Research     Hybrid Journal   (Followers: 1)
Saúde e Meio Ambiente : Revista Interdisciplinar     Open Access  
Scandinavian Journal of Work, Environment & Health     Partially Free   (Followers: 13)
Science of The Total Environment     Hybrid Journal   (Followers: 41)
Sciences Eaux & Territoires : la Revue du Cemagref     Open Access  
Smart Grid and Renewable Energy     Open Access   (Followers: 9)
Social and Environmental Accountability Journal     Hybrid Journal   (Followers: 3)
Sociedad y Ambiente     Open Access  
Soil and Sediment Contamination: An International Journal     Hybrid Journal   (Followers: 3)
Soil and Tillage Research     Hybrid Journal   (Followers: 10)
South Australian Geographical Journal     Open Access  
South Pacific Journal of Natural and Applied Sciences     Hybrid Journal  
Southern African Journal of Environmental Education     Open Access  
Southern Forests : a Journal of Forest Science     Hybrid Journal   (Followers: 4)
Sriwijaya Journal of Environment     Open Access  
Stochastic Environmental Research and Risk Assessment     Hybrid Journal   (Followers: 4)
Strategic Planning for Energy and the Environment     Hybrid Journal   (Followers: 4)
Studies in Conservation     Hybrid Journal   (Followers: 17)
Sustainability     Open Access   (Followers: 24)
Sustainability Agri Food and Environmental Research     Open Access   (Followers: 4)
Sustainability in Environment     Open Access   (Followers: 3)
Sustainable and Resilient Infrastructure     Hybrid Journal  
Sustainable Cities and Society     Hybrid Journal   (Followers: 22)
Sustainable Development     Hybrid Journal   (Followers: 14)
Sustainable Development Law & Policy     Open Access   (Followers: 12)
Sustainable Development Strategy and Practise     Open Access   (Followers: 4)
Sustainable Horizons     Full-text available via subscription   (Followers: 10)
Sustainable Technology and Entrepreneurship     Full-text available via subscription   (Followers: 7)
Sustinere : Journal of Environment and Sustainability     Open Access  
TECHNE - Journal of Technology for Architecture and Environment     Open Access   (Followers: 11)
Tecnogestión     Open Access  
Territorio della Ricerca su Insediamenti e Ambiente. Rivista internazionale di cultura urbanistica     Open Access  
The Historic Environment : Policy & Practice     Hybrid Journal   (Followers: 4)
The International Journal on Media Management     Hybrid Journal   (Followers: 7)
The Ring     Open Access  
Theoretical Ecology     Hybrid Journal   (Followers: 14)
Toxicologic Pathology     Hybrid Journal   (Followers: 18)
Toxicological & Environmental Chemistry     Hybrid Journal   (Followers: 2)
Toxicological Sciences     Hybrid Journal   (Followers: 11)
Toxicology     Hybrid Journal   (Followers: 18)
Toxicology and Applied Pharmacology     Hybrid Journal   (Followers: 24)
Toxicology and Industrial Health     Hybrid Journal   (Followers: 6)
Toxicology in Vitro     Hybrid Journal   (Followers: 11)
Toxicology Letters     Hybrid Journal   (Followers: 15)
Toxicology Mechanisms and Methods     Hybrid Journal   (Followers: 7)
Toxicon     Hybrid Journal   (Followers: 5)
Toxicon : X     Open Access  
Toxin Reviews     Hybrid Journal  
Transactions on Environment and Electrical Engineering     Open Access  
Transportation Research Part D: Transport and Environment     Hybrid Journal   (Followers: 27)
Transportation Safety and Environment     Open Access   (Followers: 1)
Transylvanian Review of Systematical and Ecological Research     Open Access  
Trends in Ecology & Evolution     Full-text available via subscription   (Followers: 276)
Trends in Environmental Analytical Chemistry     Hybrid Journal   (Followers: 3)
Trends in Pharmacological Sciences     Full-text available via subscription   (Followers: 20)
Tropicultura     Open Access  
Turkish Journal of Engineering and Environmental Sciences     Open Access   (Followers: 1)
UCLA Journal of Environmental Law and Policy     Open Access   (Followers: 2)
UD y la Geomática     Open Access  
Universidad y Ciencia     Open Access  
Universidad y Ciencia     Open Access  
UNM Environmental Journals     Open Access  
Urban Studies     Hybrid Journal   (Followers: 80)
Urban Transformations     Open Access   (Followers: 2)
Veredas do Direito : Direito Ambiental e Desenvolvimento Sustentável     Open Access  
VertigO - la revue électronique en sciences de l’environnement     Open Access   (Followers: 1)
Villanova Environmental Law Journal     Open Access   (Followers: 1)
Waste Management & Research     Hybrid Journal   (Followers: 7)
Water Conservation Science and Engineering     Hybrid Journal  
Water Environment Research     Full-text available via subscription   (Followers: 43)
Water International     Hybrid Journal   (Followers: 19)

  First | 1 2 3 4 5     

Similar Journals
Journal Cover
Toxicologic Pathology
Journal Prestige (SJR): 0.807
Citation Impact (citeScore): 2
Number of Followers: 18  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0192-6233 - ISSN (Online) 1533-1601
Published by Sage Publications Homepage  [1176 journals]
  • Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare
           During Toxicology Studies

    • Free pre-print version: Loading...

      Authors: Adeyemi O. Adedeji, Tony Pourmohamad, Niraj Tripathi, Shelly Zhong, Kenna R. Degner, Fiona Zhong, Dewakar Sangaraju, Kevin Williams, Noel Dybdal
      Abstract: Toxicologic Pathology, Ahead of Print.
      During toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys’ welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical pathology endpoints at different fasting times. We showed that most clinical pathology endpoints were largely comparable between different fasting times suggesting that cynomolgus monkeys could be fasted for as little as 4 hours for toxicology studies, as longer fasting times (up to 20 hours) resulted in stress, dehydration, and significant decreases in blood glucose- changes that impacts animal welfare. Shorter fasting times were associated with higher triglycerides variability among individual animals. Therefore, we propose that shorter fasting time (i.e., 4 hours) should be adequate for most toxicology studies except when: (1) parameters that could be affected by non-fasting conditions are important for safety and pharmacodynamic assessments (i.e., glucose and lipids) and (2) fasting would be needed for the bioavailability of an orally administered test article.
      Citation: Toxicologic Pathology
      PubDate: 2023-09-13T09:18:17Z
      DOI: 10.1177/01926233231193395
       
  • Comparative Analysis of Hypertensive Tubulopathy in Animal Models of
           Hypertension and Its Relevance to Human Pathology

    • Free pre-print version: Loading...

      Authors: Alex A. Gutsol, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns
      Abstract: Toxicologic Pathology, Ahead of Print.
      Assessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed—chronic angiotensin (Ang) II–infused and renin-overexpressing (TTRhRen) mice, spontaneously hypertensive (SHR), and Goldblatt two-kidney one-clip (2K1C) rats. Mouse models, SHR, and the nonclipped kidney in 2K1C rats had no regular signs of hypertensive tubulopathy. Histopathology in animals was mild and limited to variations in the volume density of tubular lumen and epithelium, interstitial space, and interstitial collagen. Affected kidneys in animals demonstrated lesion values that are significantly different compared with healthy controls but correspond to mild damage if compared with hypertensive humans. The most substantial human-like hypertensive tubulopathy was detected in the clipped kidney of 2K1C rats. For the first time, our study demonstrated the regular presence of chronic progressive nephropathy (CPN) in relatively young mice and rats with induced hypertension. Because CPN may confound the assessment of rodent models of hypertension, proliferative markers should be used to verify nonhypertensive tubulopathy.
      Citation: Toxicologic Pathology
      PubDate: 2023-08-26T11:22:12Z
      DOI: 10.1177/01926233231191128
       
  • Musings on Education for Toxicologic Pathology Proficiency in a
           Post-pandemic, Remotely Working World

    • Free pre-print version: Loading...

      Authors: Brad Bolon
      Abstract: Toxicologic Pathology, Ahead of Print.

      Citation: Toxicologic Pathology
      PubDate: 2023-08-14T12:04:24Z
      DOI: 10.1177/01926233231190403
       
  • Toxicologic Pathology Forum: Considerations Regarding Determination of
           Adversity for Immunopathology Findings in Nonclinical Toxicology Studies
           with Immune-Modulating Therapeutics

    • Free pre-print version: Loading...

      Authors: Tracey L. Papenfuss, Lauren Himmel, C. Frieke Kuper, Sunish Mohanan, Johannes Harleman, Susan A. Elmore
      Abstract: Toxicologic Pathology, Ahead of Print.
      The evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact interpretation. Recent explosive growth in immunomodulatory therapies presents a challenge to the toxicologic pathologist, toxicologist, and regulatory reviewer in terms of evaluating the clinical relevance and potential adversity of immune system changes. Beyond the recognition of such changes, there is an increasing expectation to evaluate, describe, and interpret how therapies affect complex immune system pathways for both immunomodulatory therapies and non-immunomodulatory drugs with off-target immunotoxic effects. In this opinion piece, considerations regarding immune system evaluation, the current landscape of immunomodulatory therapies, a brief description of immunotoxicologic (and immunopathologic) endpoints, the importance of integrating such immunosafety data, and relevance to adversity determination are discussed. Importantly, we describe how the current paradigm of determining adversity for immune system changes may be challenging or insufficient and propose a harmonized and flexible approach for assessing adversity.
      Citation: Toxicologic Pathology
      PubDate: 2023-08-14T12:02:28Z
      DOI: 10.1177/01926233231190382
       
  • Scientific and Regulatory Policy Committee Points to Consider: Sampling,
           Processing, Evaluation, Interpretation, and Reporting of Test
           Article-Related Ganglion Pathology for Nonclinical Toxicity Studies

    • Free pre-print version: Loading...

      Authors: Bindu M. Bennet, Ingrid D. Pardo, Basel T. Assaf, Elizabeth Buza, Sarah Cramer, LaTasha K. Crawford, Jeffery A. Engelhardt, Branka Grubor, James P. Morrison, Tanasa S. Osborne, Alok K. Sharma, Brad Bolon
      Abstract: Toxicologic Pathology, Ahead of Print.
      Certain biopharmaceutical products consistently affect dorsal root ganglia, trigeminal ganglia, and/or autonomic ganglia. Product classes targeting ganglia include antineoplastic chemotherapeutics, adeno-associated virus-based gene therapies, antisense oligonucleotides, and anti-nerve growth factor agents. This article outlines “points to consider” for sample collection, processing, evaluation, interpretation, and reporting of ganglion findings; these points are consistent with published best practices for peripheral nervous system evaluation in nonclinical toxicity studies. Ganglion findings often occur as a combination of neuronal injury (e.g., degeneration, necrosis, and/or loss) and/or glial effects (e.g., increased satellite glial cell cellularity) with leukocyte accumulation (e.g., mononuclear cell infiltration or inflammation). Nerve fiber degeneration and/or glial reactions may be seen in nerves, dorsal spinal nerve roots, spinal cord, and occasionally brainstem. Interpretation of test article (TA)-associated effects may be confounded by incidental background changes or experimental procedure-related changes and limited historical control data. Reports should describe findings at these sites, any TA relationship, and the criteria used for assigning severity grades. Contextualizing adversity of ganglia findings can require a weight-of-evidence approach because morphologic changes of variable severity occur in ganglia but often are not accompanied by observable overt in-life functional alterations detectable by conventional behavioral and neurological testing techniques.
      Citation: Toxicologic Pathology
      PubDate: 2023-07-25T09:07:00Z
      DOI: 10.1177/01926233231179707
       
  • European Society of Toxicologic Pathology (Pathology 2.0 Molecular
           Pathology Special Interest Group): Review of In Situ Hybridization
           Techniques for Drug Research and Development

    • Free pre-print version: Loading...

      Authors: Josep M. Monné Rodríguez, Anna-Lena Frisk, Robert Kreutzer, Thomas Lemarchand, Stephane Lezmi, Chandrassegar Saravanan, Birgit Stierstorfer, Céline Thuilliez, Enrico Vezzali, Grazyna Wieczorek, Seong-Wook Yun, Dirk Schaudien
      Abstract: Toxicologic Pathology, Ahead of Print.
      In situ hybridization (ISH) is used for the localization of specific nucleic acid sequences in cells or tissues by complementary binding of a nucleotide probe to a specific target nucleic acid sequence. In the last years, the specificity and sensitivity of ISH assays were improved by innovative techniques like synthetic nucleic acids and tandem oligonucleotide probes combined with signal amplification methods like branched DNA, hybridization chain reaction and tyramide signal amplification. These improvements increased the application spectrum for ISH on formalin-fixed paraffin-embedded tissues. ISH is a powerful tool to investigate DNA, mRNA transcripts, regulatory noncoding RNA, and therapeutic oligonucleotides. ISH can be used to obtain spatial information of a cell type, subcellular localization, or expression levels of targets. Since immunohistochemistry and ISH share similar workflows, their combination can address simultaneous transcriptomics and proteomics questions. The goal of this review paper is to revisit the current state of the scientific approaches in ISH and its application in drug research and development.
      Citation: Toxicologic Pathology
      PubDate: 2023-07-14T09:22:38Z
      DOI: 10.1177/01926233231178282
       
  • Neurofilament Light Chain: A Translational Safety Biomarker for
           Drug-Induced Peripheral Neurotoxicity

    • Free pre-print version: Loading...

      Authors: Diethilde Theil, Jens Kuhle, Dominique Brees, Elaine Tritto, François Pognan, Wilfried Frieauff, Kelley Penraat, Emily Meseck, Reginald Valdez, Andreas Hartmann
      Abstract: Toxicologic Pathology, Ahead of Print.
      Branaplam is a splicing modulator previously under development as a therapeutic agent for Spinal Muscular Atrophy Type 1 and Huntington’s disease. Branaplam increased the levels of survival motor neuron protein in preclinical studies and was well tolerated in early clinical studies; however, peripheral neurotoxicity was observed in a preclinical safety study in juvenile dogs. The aim of this study was to determine whether serum neurofilament light chain (NfL) concentrations in dogs could serve as a monitoring biomarker for branaplam-induced peripheral neurotoxicity. A 30-week time-course investigative study in dogs treated with vehicle control (negative control), neurotoxic pyridoxine (positive control), or branaplam was conducted to assess neuropathology, nerve morphometry, electrophysiological measurements, gene expression profiles, and correlation to NfL serum concentrations. In branaplam-treated animals, a mild to moderate nerve fiber degeneration was observed in peripheral nerves correlating with increased serum NfL concentrations, but there were no observed signs or changes in electrophysiological parameters. Dogs with pyridoxine-induced peripheral axonal degeneration displayed clinical signs and electrophysiological changes in addition to elevated serum NfL. This study suggests that NfL may be useful as an exploratory biomarker to assist in detecting and monitoring treatment-related peripheral nerve injury, with or without clinical signs, associated with administration of branaplam and other compounds bearing a neurotoxic risk.
      Citation: Toxicologic Pathology
      PubDate: 2023-07-13T06:07:27Z
      DOI: 10.1177/01926233231180179
       
  • Retinal and Systemic Toxicity of Vigabatrin Is Driven by the S-Enantiomer
           in the Long Evans Rat

    • Free pre-print version: Loading...

      Authors: Allan D. Rasmussen, Nathalie Truchot, Agnete Dyssegaard, Pierluigi Fant
      Abstract: Toxicologic Pathology, Ahead of Print.
      In this study, we assessed the toxicity and toxicokinetics of racemic vigabatrin and its S- and R-enantiomers (vigabatrin consists of 50:50% of the two enantiomers) by administering doses of the three test articles to male Long Evans rats via oral gavage. The animals were housed under high-intensity light conditions and the study consisted of an escalating dose phase and a 21-day fixed-dose phase. Systemic toxicity of vigabatrin appears to be due to the Vig-S-enantiomer only, as increasing doses of Vig-S or Vig-RS caused body weight loss, decreased food consumption, and affected activity. Administration of the Vig-R-enantiomer did not cause any such effects. Systemic exposure to R- and S-enantiomers was approximately linear with dose. Compared to administration of the racemate, there appeared to be a tendency for animals to take up higher amounts of Vig-R and lower amounts of Vig-S when administered as enantiomer. Bilateral retinal atrophy was observed in the fixed-dose phase in rats receiving Vig-S (either alone or as part of Vig-RS) and was characterized by irregular thinning and disorganization of the outer nuclear layer and thinning of the photoreceptor layer. The administration of the R-enantiomer alone did not cause any microscopic retinal change.
      Citation: Toxicologic Pathology
      PubDate: 2023-07-04T09:20:28Z
      DOI: 10.1177/01926233231179147
       
  • Corrigendum to Histology Atlas of the Developing Mouse Placenta

    • Free pre-print version: Loading...

      Abstract: Toxicologic Pathology, Ahead of Print.

      Citation: Toxicologic Pathology
      PubDate: 2023-05-10T04:49:00Z
      DOI: 10.1177/01926233231175051
       
  • Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury
           in a Diet-Induced NAFLD Mouse Model

    • Free pre-print version: Loading...

      Authors: Takeshi Izawa, Gregory S. Travlos, Ricardo A. Cortes, Natasha P. Clayton, Robert C. Sills, Arun R. Pandiri
      Abstract: Toxicologic Pathology, Ahead of Print.
      Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease and its influence on drug-induced liver injury (DILI) is not fully understood. We investigated whether NAFLD can influence acetaminophen (APAP [N-acetyl-p-aminophenol])-induced hepatotoxicity in a diet-induced obese (DIO) mouse model of NAFLD. The male C57BL/6NTac DIO mice, fed a high-fat diet for more than 12 weeks, developed obesity, hyperinsulinemia, impaired glucose tolerance, and hepatomegaly with hepatic steatosis, similar to human NAFLD. In the acute toxicity study after a single dose of APAP (150 mg/kg), compared with control lean mice, the DIO mice had decreased serum transaminase levels and less severe hepatocellular injury. The DIO mice also had altered expression of genes related to APAP metabolism. Chronic APAP exposure for 26 weeks did not predispose the DIO mice with NAFLD to more severe hepatotoxicity compared with the lean mice. These results suggested that the C57BL/6NTac DIO mouse model appears to be more tolerant to APAP-induced hepatotoxicity than lean mice, potentially related to altered xenobiotic metabolizing capacity in the fatty liver. Further mechanistic studies with APAP and other drugs in NAFLD animal models are necessary to investigate the mechanism of altered susceptibility to intrinsic DILI in some human NAFLD patients.
      Citation: Toxicologic Pathology
      PubDate: 2023-05-09T12:11:45Z
      DOI: 10.1177/01926233231171101
       
  • Toxicologic Pathology Forum: Opinion on Performing Good Laboratory
           Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a
           Remote Location

    • Free pre-print version: Loading...

      Authors: Renee R. Hukkanen, Michelle Trapani, Tana Derringer, Victoria Laast, Zbigniew W. Wojcinski, Rosa Anna Manno, Matthias Rinke, Eric van Esch, Alys E. Bradley, Patrizia Cristofori, Roger Alison, Barb Munch
      Abstract: Toxicologic Pathology, Ahead of Print.
      Toxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonly in home-office settings. A study pathologist (SP) generating data on GLP-compliant nonclinical studies must be keenly aware of applicable national GLP regulations and comply with TF and protocol requirements. This Toxicological Pathology Forum Opinion Piece will summarize primary areas of emphasis for the SP generating GLP data using glass slides. Peer review and digital review of whole slide images are out of scope for this opinion piece. Key GLP considerations for primary pathology on glass slides are discussed with respect to SP location and employment status, including pathologist qualifications, specimen management, facilities, equipment, archive, and quality assurance. Notable differences between national GLP regulations of the United States, the United Kingdom, Germany, the Netherlands, France, Ireland, Switzerland, Italy, and Israel are presented. With the understanding that each combination of location and employment is unique, the authors provide a general overview of considerations for successful remote GLP work.
      Citation: Toxicologic Pathology
      PubDate: 2023-04-26T12:04:05Z
      DOI: 10.1177/01926233231168133
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 34.204.172.188
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-